Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	-	RASEF KASH5 UTRN RYR1	3.54e-03	261	45	4	1.10.238.10
Domain	EF-hand-dom_pair	RASEF KASH5 UTRN RYR1	4.96e-03	287	45	4	IPR011992
Domain	DNAJ_1	DNAJC1 SACS	6.21e-03	49	45	2	PS00636
Domain	DNAJ_2	DNAJC1 SACS	6.21e-03	49	45	2	PS50076
Domain	DnaJ	DNAJC1 SACS	6.21e-03	49	45	2	SM00271
Domain	-	DNAJC1 SACS	6.21e-03	49	45	2	1.10.287.110
Domain	DnaJ_domain	DNAJC1 SACS	6.71e-03	51	45	2	IPR001623
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	TMEM184C IFT122 PRPF6 CHD4 CFAP210 GSPT2 SACS TFAM NDUFS1 MED13 PHTF1 SANBR	4.29e-07	1442	48	12	35575683
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	CDC37 DAPK1 CHD4 ASAP2 WLS SACS SVIL	1.24e-06	400	48	7	35013556
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	DOCK10 CDC37 PRPF6 ASAP2 NUP93 EIF3D PEAK1 UTRN TFAM	3.91e-06	916	48	9	32203420
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CDC37 AKT2 IFT122 PRPF6 DNAJC1 PEAK1 STBD1 SACS TFAM NDUFS1 SPICE1	4.42e-06	1487	48	11	33957083
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	CDC37 PRPF6 CHD4 NUP93 EIF3D GSPT2 NDUFS1 MED13 SVIL SPICE1	6.40e-06	1247	48	10	27684187
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CDC37 AKT2 DNAJC1 STBD1 WLS NDUFS1 VPS50 ZFP1	6.72e-06	733	48	8	34672954
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	LMAN2 PRPF6 CHD4 NUP93 EIF3D SACS UTRN TFAM SVIL	9.59e-06	1024	48	9	24711643
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	CDC37 NUP93 GSPT2 UTRN NDUFS1 SVIL	1.00e-05	360	48	6	33111431
Pubmed	Defining the membrane proteome of NK cells.	DOCK10 IFT122 PRPF6 CHD4 DNAJC1 NUP93 EIF3D MED13 VPS50	2.72e-05	1168	48	9	19946888
Pubmed	Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.	CDC37 AKT2	2.79e-05	6	48	2	12176997
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	DAPK1 PRPF6 CHD4 EIF3D	6.03e-05	153	48	4	26365490
Pubmed	Genetic Steroid-Resistant Nephrotic Syndrome Overview	NUP93 PTPRO	6.67e-05	9	48	2	34436835
Pubmed	The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.	LMAN2 CHD4 NUP93 EIF3D NDUFS1	7.91e-05	320	48	5	28685749
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DOCK10 CDC37 PRPF6 CHD4 NUP93 EIF3D UTRN TFAM NDUFS1	8.47e-05	1353	48	9	29467282
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	TXNRD1 CDC37 PRPF6 CHD4 NUP93 EIF3D UTRN TFAM CFAP36	9.16e-05	1367	48	9	32687490
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	CDC37 PRPF6 CHD4 NUP93 EIF3D TFAM NDUFS1	9.64e-05	786	48	7	29128334
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	TXNRD1 CDC37 DAPK1 CHD4 PEAK1 UTRN RYR1	1.14e-04	807	48	7	30575818
Pubmed	Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family.	ASAP2 PEAK1	1.22e-04	12	48	2	35192416
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PITPNM1 DAPK1 SNPH PEAK1 SACS UTRN TFAM NDUFS1 SVIL	1.30e-04	1431	48	9	37142655
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	CDC37 NUP93 PEAK1 PTPRO UTRN TFAM	1.33e-04	573	48	6	28330616
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CDC37 LMAN2 PRPF6 CHD4 DNAJC1 NUP93 EIF3D TFAM NDUFS1	1.36e-04	1440	48	9	30833792
Pubmed	Genome-wide analysis of gene transcription in the hypothalamus.	PITPNM1 PTPRO	1.44e-04	13	48	2	15870395
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	PRPF6 NUP93 EIF3D SLX4 SVIL ANAPC4 SPICE1 ZFP1	1.67e-04	1155	48	8	20360068
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	DOCK10 ASAP2 RYR1 PHTF1	1.97e-04	208	48	4	33230847
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CDC37 PRPF6 CHD4 NUP93 EIF3D NDUFS1	2.37e-04	638	48	6	33239621
Pubmed	Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.	DAPK1 TFAM	2.50e-04	17	48	2	20413850
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	PRPF6 CHD4 NUP93 TFAM NDUFS1 SVIL	2.67e-04	652	48	6	31180492
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PRPF6 CHD4 NUP93 EIF3D UTRN NDUFS1	2.69e-04	653	48	6	22586326
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	CDC37 LMAN2 CHD4 NUP93 WLS NDUFS1	2.78e-04	657	48	6	36180527
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	PRPF6 CHD4 NUP93 SLX4 ANAPC4	3.47e-04	440	48	5	34244565
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	PRPF6 CHD4 EIF3D UTRN TFAM NDUFS1	4.23e-04	711	48	6	33022573
Pubmed	Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling.	TFAM RYR1	4.23e-04	22	48	2	35081489
Pubmed	Assessment of Alzheimer's disease case-control associations using family-based methods.	DAPK1 TFAM	4.23e-04	22	48	2	18830724
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	CDC37 PRPF6 CHD4 NUP93 EIF3D UTRN NDUFS1	4.32e-04	1005	48	7	19615732
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SLX4 VPS50 SANBR	4.43e-04	107	48	3	11347906
Pubmed	Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.	CDC37 PRPF6 CHD4 EIF3D	4.52e-04	259	48	4	31162944
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	PEAK1 STBD1 UTRN SVIL	4.79e-04	263	48	4	34702444
Pubmed	Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.	CDC37 PRPF6 CHD4	5.19e-04	113	48	3	23403292
Pubmed	Proteomic profiling of Myc-associated proteins.	PRPF6 NUP93 TFAM	5.33e-04	114	48	3	21150319
Pubmed	Intermediate phenotypes identify divergent pathways to Alzheimer's disease.	DAPK1 TFAM	5.48e-04	25	48	2	20574532
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	CHD4 UTRN NDUFS1 MED13 RYR1	6.03e-04	497	48	5	23414517
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	PRPF6 EIF3D SACS SVIL VPS50	6.08e-04	498	48	5	36634849
Pubmed	Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease.	CDC37 EIF3D	6.40e-04	27	48	2	36266428
Pubmed	A Grhl2-dependent gene network controls trophoblast branching morphogenesis.	PLAC1 TEX19	6.40e-04	27	48	2	25758223
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PRPF6 CHD4 EIF3D SACS PTPRO TFAM NDUFS1	6.69e-04	1082	48	7	38697112
Pubmed	The functional interactome landscape of the human histone deacetylase family.	PRPF6 CHD4 NUP93 SVIL	6.81e-04	289	48	4	23752268
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	CDC37 LMAN2 PRPF6 CHD4 NUP93 EIF3D PEAK1 NDUFS1	6.82e-04	1425	48	8	30948266
Pubmed	Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.	DAPK1 TFAM	6.89e-04	28	48	2	20534741
Pubmed	Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.	PRPF6 NUP93 NDUFS1	7.63e-04	129	48	3	28973437
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	CDC37 CHD4 NUP93 EIF3D NDUFS1	8.32e-04	534	48	5	35032548
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	CDC37 PRPF6 CHD4 ASAP2 EIF3D STBD1 TFAM	9.71e-04	1153	48	7	29845934
Pubmed	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.	TXNRD1 CDC37 EIF3D PEAK1	1.08e-03	327	48	4	15592455
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	VPREB1 ASAP2 EIF3D RYR1	1.10e-03	329	48	4	17474147
Pubmed	The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.	PRPF6 CHD4 SVIL	1.11e-03	147	48	3	28977470
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	CHD4 UTRN TFAM	1.11e-03	147	48	3	29576527
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	TXNRD1 DOCK10 NUP93 UTRN TFAM NDUFS1	1.13e-03	859	48	6	31536960
Pubmed	Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.	TFAM NDUFS1	1.20e-03	37	48	2	20843780
Pubmed	TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.	CHD4 NUP93 TFAM	1.23e-03	152	48	3	28192407
Pubmed	Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.	ASAP2 SVIL	1.34e-03	39	48	2	19010793
Cytoband	20p11.1	FAM182A FAM182B	7.02e-05	12	48	2	20p11.1
Disease	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	NUP93 PTPRO	1.01e-03	30	46	2	C1868672
Disease	amyotrophic lateral sclerosis (is_implicated_in)	TXNRD1 TFAM	1.14e-03	32	46	2	DOID:332 (is_implicated_in)
Disease	multiple sclerosis	DOCK10 CDC37 LMAN2 ASAP2 SVIL	2.26e-03	594	46	5	MONDO_0005301
Disease	Leukemia, Myelocytic, Acute	DAPK1 SLX4 SVIL	2.50e-03	173	46	3	C0023467
Disease	creatinine measurement	PLAC1 AKT2 LMAN2 STBD1 RYR1 SVIL	4.29e-03	995	46	6	EFO_0004518

Protein segments in the cluster

Peptide	Gene	Start	Entry
LAMWDVSDIRDDISE	TMEM184C	331	Q9NVA4
RTFHVDSPDEREEWM	AKT2	86	P31751
NLHRSWADEEDEVMV	DAPK1	1111	P53355
SIWMERDTANEAETH	CABS1	296	Q96KC9
VRVFEMDIDDEWELD	ANAPC4	741	Q9UJX5
MAAEEEDEVEWVVES	CFAP36	1	Q96G28
HGTSIEEIEEQMDDW	DNAJC1	301	Q96KC8
EEYHRESMLVEWEQV	NUP93	126	Q8N1F7
NIREWVDMIEDAAHE	RASEF	631	Q8IZ41
SMWLTRREEEEDAES	KASH5	441	Q8N6L0
VTDTDWRELAMEALE	IFT122	641	Q9HBG6
DHWDEVKEEMTSALA	MAPKAPK3	326	Q16644
LMVEHTPDEESIDWT	LMAN2	276	Q12907
WRLLHEDLDESDDDM	ASAP2	691	O43150
VRELWMWNVEEEEHE	FAM182A	61	Q5T1J6
EVEMALEESWEHSKE	GSPT2	141	Q8IYD1
LFSNMEEEHESWDES	PEAK1	241	Q9H792
SWDESDEELLAMEIR	PEAK1	251	Q9H792
RELWMWNVEEEEHEV	FAM182B	6	Q5T319
EMISEEEQDDWACRH	PTPRO	1066	Q16827
AAETESDMDEWIHTL	DOCK10	271	Q96BY6
MVDYSVWDHIEVSDD	CDC37	1	Q16543
SVEVRSDWEVKEEMD	EIF3D	161	O15371
MDFDDERTWTDLEEN	CENPJ	791	Q9HC77
EDWGMEDIDHVFSEE	CHD4	156	Q14839
DDILWDDMLERAVSV	SACS	2156	Q9NZJ4
WILTEDHSFEDRMID	RYR1	3661	P21817
DISEDWSLHTDDMIG	PLAC1	196	Q9HBJ0
WDDHREETEELMRKY	UTRN	2341	P46939
SWEHREDIAEITEMD	SVIL	2121	O95425
SSGEEEQDHWEEMKE	SYT16	616	Q17RD7
RMHEDINEEWISDKT	NDUFS1	276	P28331
EEDRKHTWMEDADSC	PRPF6	536	O94906
EVRMSKEEDSIWFHS	IL1RAPL2	91	Q9NP60
DMDWEDDSLAAVEVL	MED13	256	Q9UHV7
RMQEDWIEEECHRVE	SNPH	116	O15079
EDETRYHNEMKSWEE	TFAM	206	Q00059
SMDAQRWEEVDISVH	SANBR	181	Q6NSI8
VEHEMEEYERWTGRE	SPICE1	341	Q8N0Z3
QELLRSMWADEEEEA	SLX4	816	Q8IY92
MIIARDIAEAEAEWE	CFAP210	346	Q0VFZ6
DEWTELSMADIRALE	PITPNM1	231	O00562
EETVKHDWDRMIEAV	TXNRD1	241	Q16881
RTMEWHEKHDNEDTA	VPS50	341	Q96JG6
SVEVWKADDQMERDH	ZFP1	46	Q6P2D0
DLNSQDRVDHEEWEM	STBD1	191	O95210
STRHDSETEDMLWDD	PHTF1	371	Q9UMS5
SSEKEEREREWEEEM	VPREB1	121	P12018
RDDAFAEWTEMAHER	WLS	141	Q5T9L3
EDNWDPELMEHTEAE	TEX19	56	Q8NA77