Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionankyrin binding

SPTBN4 SPTB SPTBN1

4.78e-0623293GO:0030506
GeneOntologyMolecularFunctionactin filament binding

SPTBN4 ACTR3B MYO7A SPTB SPTBN1

1.73e-05227295GO:0051015
GeneOntologyMolecularFunctionstructural constituent of cytoskeleton

SPTBN4 MYOM2 SPTB SPTBN1

3.59e-05130294GO:0005200
GeneOntologyMolecularFunctioncytoskeletal protein binding

SPTBN4 SPAG9 ACTR3B MYO7A MARK1 SPTB SPTBN1 MAPK8IP3

1.25e-041099298GO:0008092
GeneOntologyMolecularFunctionMAP-kinase scaffold activity

SPAG9 MAPK8IP3

1.57e-0413292GO:0005078
GeneOntologyMolecularFunctionJUN kinase binding

SPAG9 MAPK8IP3

2.73e-0417292GO:0008432
GeneOntologyMolecularFunctionactin binding

SPTBN4 ACTR3B MYO7A SPTB SPTBN1

5.74e-04479295GO:0003779
GeneOntologyMolecularFunctionK63-linked polyubiquitin modification-dependent protein binding

SPRTN IKBKE

6.48e-0426292GO:0070530
GeneOntologyMolecularFunctionspectrin binding

SPTBN4 MYO7A

1.11e-0334292GO:0030507
GeneOntologyMolecularFunctionsignaling receptor complex adaptor activity

SPAG9 MAPK8IP3

2.78e-0354292GO:0030159
GeneOntologyMolecularFunctionkinesin binding

SPAG9 MAPK8IP3

2.88e-0355292GO:0019894
GeneOntologyMolecularFunctionpolyubiquitin modification-dependent protein binding

SPRTN IKBKE

3.31e-0359292GO:0031593
GeneOntologyBiologicalProcessactin filament capping

SPTBN4 SPTB SPTBN1

3.27e-0546283GO:0051693
GeneOntologyBiologicalProcessnegative regulation of actin filament depolymerization

SPTBN4 SPTB SPTBN1

4.74e-0552283GO:0030835
GeneOntologyBiologicalProcessregulation of actin filament polymerization

SPTBN4 MTOR SPTB SPTBN1

5.60e-05156284GO:0030833
GeneOntologyBiologicalProcessNADP metabolic process

IDH1 MTOR SHPK

5.92e-0556283GO:0006739
GeneOntologyBiologicalProcessregulation of actin filament depolymerization

SPTBN4 SPTB SPTBN1

7.65e-0561283GO:0030834
GeneOntologyBiologicalProcessregulation of actin polymerization or depolymerization

SPTBN4 MTOR SPTB SPTBN1

9.14e-05177284GO:0008064
GeneOntologyBiologicalProcessactin filament depolymerization

SPTBN4 SPTB SPTBN1

9.68e-0566283GO:0030042
GeneOntologyBiologicalProcessregulation of actin filament length

SPTBN4 MTOR SPTB SPTBN1

9.75e-05180284GO:0030832
GeneOntologyBiologicalProcessactin filament polymerization

SPTBN4 MTOR SPTB SPTBN1

1.20e-04190284GO:0030041
GeneOntologyBiologicalProcessnegative regulation of actin filament polymerization

SPTBN4 SPTB SPTBN1

1.42e-0475283GO:0030837
GeneOntologyBiologicalProcessactin polymerization or depolymerization

SPTBN4 MTOR SPTB SPTBN1

2.18e-04222284GO:0008154
GeneOntologyBiologicalProcessnegative regulation of protein depolymerization

SPTBN4 SPTB SPTBN1

2.35e-0489283GO:1901880
GeneOntologyBiologicalProcessnegative regulation of protein polymerization

SPTBN4 SPTB SPTBN1

2.51e-0491283GO:0032272
GeneOntologyBiologicalProcessregulation of protein polymerization

SPTBN4 MTOR SPTB SPTBN1

2.54e-04231284GO:0032271
GeneOntologyBiologicalProcessnegative regulation of protein-containing complex disassembly

SPTBN4 SPTB SPTBN1

3.32e-04100283GO:0043242
GeneOntologyBiologicalProcessregulation of protein depolymerization

SPTBN4 SPTB SPTBN1

3.83e-04105283GO:1901879
GeneOntologyBiologicalProcesspentose-phosphate shunt

MTOR SHPK

4.04e-0422282GO:0006098
GeneOntologyBiologicalProcesscell maturation

TDRD7 SPTBN4 RHEX MTOR

4.40e-04267284GO:0048469
GeneOntologyBiologicalProcessregulation of protein-containing complex assembly

SPTBN4 IKBKE MTOR SPTB SPTBN1

4.59e-04489285GO:0043254
GeneOntologyBiologicalProcessNADPH regeneration

MTOR SHPK

5.23e-0425282GO:0006740
GeneOntologyBiologicalProcessactin filament organization

SPTBN4 MYO7A MTOR SPTB SPTBN1

5.51e-04509285GO:0007015
GeneOntologyBiologicalProcessactin cytoskeleton organization

SPTBN4 MYOM2 MYO7A MTOR SPTB SPTBN1

6.17e-04803286GO:0030036
GeneOntologyBiologicalProcessregulation of actin filament organization

SPTBN4 MTOR SPTB SPTBN1

6.82e-04300284GO:0110053
GeneOntologyBiologicalProcesspeptidyl-serine phosphorylation

SPTBN4 IKBKE MTOR MARK1

7.43e-04307284GO:0018105
GeneOntologyBiologicalProcesspeptidyl-serine modification

SPTBN4 IKBKE MTOR MARK1

8.57e-04319284GO:0018209
GeneOntologyBiologicalProcessglucose 6-phosphate metabolic process

MTOR SHPK

8.60e-0432282GO:0051156
GeneOntologyBiologicalProcessprotein depolymerization

SPTBN4 SPTB SPTBN1

9.61e-04144283GO:0051261
GeneOntologyBiologicalProcessregulation of protein-containing complex disassembly

SPTBN4 SPTB SPTBN1

9.61e-04144283GO:0043244
GeneOntologyBiologicalProcessprotein polymerization

SPTBN4 MTOR SPTB SPTBN1

1.02e-03334284GO:0051258
GeneOntologyBiologicalProcessactin filament-based process

SPTBN4 MYOM2 MYO7A MTOR SPTB SPTBN1

1.20e-03912286GO:0030029
GeneOntologyBiologicalProcessanatomical structure maturation

TDRD7 SPTBN4 RHEX MTOR

1.26e-03354284GO:0071695
GeneOntologyBiologicalProcesspurine nucleotide metabolic process

IDH1 MTOR NDUFS1 SULT1C3 SHPK

1.33e-03619285GO:0006163
GeneOntologyCellularComponentspectrin

SPTBN4 SPTB SPTBN1

2.01e-079293GO:0008091
GeneOntologyCellularComponentspectrin-associated cytoskeleton

SPTB SPTBN1

6.65e-059292GO:0014731
GeneOntologyCellularComponentmain axon

SPTBN4 SPTBN1 MAPK8IP3

2.52e-0489293GO:0044304
GeneOntologyCellularComponentcortical actin cytoskeleton

SPTBN4 SPTB SPTBN1

2.86e-0493293GO:0030864
GeneOntologyCellularComponentaxolemma

SPTBN1 MAPK8IP3

3.84e-0421292GO:0030673
GeneOntologyCellularComponentPML body

SPTBN4 IKBKE MTOR

6.81e-04125293GO:0016605
GeneOntologyCellularComponentcortical cytoskeleton

SPTBN4 SPTB SPTBN1

7.46e-04129293GO:0030863
GeneOntologyCellularComponentM band

MYOM2 SPTBN1

8.43e-0431292GO:0031430
GeneOntologyCellularComponentactin cytoskeleton

SPTBN4 KLHL14 MYO7A SPTB SPTBN1

1.07e-03576295GO:0015629
GeneOntologyCellularComponentcell cortex

SPTBN4 MYO7A SPTB SPTBN1

1.63e-03371294GO:0005938
GeneOntologyCellularComponentA band

MYOM2 SPTBN1

2.36e-0352292GO:0031672
DomainSpectrin_bsu

SPTBN4 SPTB SPTBN1

1.21e-084283IPR016343
DomainJIP_LZII

SPAG9 MAPK8IP3

2.17e-062282IPR032486
DomainJIP_LZII

SPAG9 MAPK8IP3

2.17e-062282PF16471
DomainActinin_actin-bd_CS

SPTBN4 SPTB SPTBN1

5.24e-0623283IPR001589
DomainACTININ_2

SPTBN4 SPTB SPTBN1

5.24e-0623283PS00020
DomainACTININ_1

SPTBN4 SPTB SPTBN1

5.24e-0623283PS00019
DomainSpectrin

SPTBN4 SPTB SPTBN1

5.24e-0623283PF00435
DomainSpectrin_repeat

SPTBN4 SPTB SPTBN1

1.07e-0529283IPR002017
DomainJnk-SapK_ap_N

SPAG9 MAPK8IP3

1.30e-054282PF09744
DomainJNK/Rab-associated_protein-1_N

SPAG9 MAPK8IP3

1.30e-054282IPR019143
DomainSpectrin/alpha-actinin

SPTBN4 SPTB SPTBN1

1.45e-0532283IPR018159
DomainSPEC

SPTBN4 SPTB SPTBN1

1.45e-0532283SM00150
DomainRH2

SPAG9 MAPK8IP3

2.16e-055282PS51777
DomainRH1

SPAG9 MAPK8IP3

2.16e-055282PS51776
DomainPH_dom-spectrin-type

SPTBN4 SPTBN1

7.75e-059282IPR001605
DomainCH

SPTBN4 SPTB SPTBN1

1.24e-0465283SM00033
DomainCH

SPTBN4 SPTB SPTBN1

1.54e-0470283PF00307
Domain-

SPTBN4 SPTB SPTBN1

1.61e-04712831.10.418.10
DomainCH

SPTBN4 SPTB SPTBN1

1.75e-0473283PS50021
DomainCH-domain

SPTBN4 SPTB SPTBN1

1.90e-0475283IPR001715
Domain-

KLHL14 KLHDC4

2.34e-03482822.120.10.80
DomainKelch-typ_b-propeller

KLHL14 KLHDC4

3.06e-0355282IPR015915
DomainGal_Oxase/kelch_b-propeller

KLHL14 KLHDC4

3.52e-0359282IPR011043
DomainKelch_1

KLHL14 KLHDC4

4.91e-0370282PF01344
DomainKelch_1

KLHL14 KLHDC4

4.91e-0370282IPR006652
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTBN4 SPTB SPTBN1

4.52e-0710233MM15112
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTBN4 SPTB SPTBN1

1.66e-0531233M877
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

SPTBN4 SPTB SPTBN1

3.08e-0538233MM14969
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

SPTBN4 SPTB SPTBN1

1.41e-0463233M11187
PathwayREACTOME_L1CAM_INTERACTIONS

SPTBN4 SPTB SPTBN1

1.77e-0468233MM14968
PathwayREACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT

SPTBN4 SPTB SPTBN1

5.86e-04102233M27648
PathwayREACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT

SPTBN4 SPTB SPTBN1

7.31e-04110233MM15350
Pubmed

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.

SPTBN4 MYO7A SPTB SPTBN1

2.77e-101329418796539
Pubmed

A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.

SPTBN4 SPTB SPTBN1

5.21e-10329311294830
Pubmed

β spectrin-dependent and domain specific mechanisms for Na+ channel clustering.

SPTBN4 SPTB SPTBN1

5.21e-10329332425157
Pubmed

Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.

SPTBN4 SPTB SPTBN1

8.56e-081129317607528
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

SPTBN4 SPTB SPTBN1

4.22e-071829312119179
Pubmed

Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif.

SPAG9 MAPK8IP3

6.71e-07229231690808
Pubmed

Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons.

SPAG9 MAPK8IP3

6.71e-07229233788575
Pubmed

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

SPTBN4 SPTB SPTBN1

1.18e-06252938493579
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CUL5 SPTBN4 ACTR3B MYO7A MARK1 NDUFS1 SPTB SPTBN1 MAPK8IP3

1.56e-06143129937142655
Pubmed

Overexpression of mTOR and p(240-244)S6 in IDH1 Wild-Type Human Glioblastomas Is Predictive of Low Survival.

IDH1 MTOR

2.01e-06329229328863
Pubmed

The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons.

SPAG9 MAPK8IP3

2.01e-06329220493856
Pubmed

JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration.

SPAG9 MAPK8IP3

2.01e-06329225571974
Pubmed

The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences.

SPTB SPTBN1

2.01e-0632928479293
Pubmed

JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis.

SPAG9 MAPK8IP3

2.01e-06329225130574
Pubmed

Nodal β spectrins are required to maintain Na+ channel clustering and axon integrity.

SPTBN4 SPTB

2.01e-06329232052742
Pubmed

Developmental expression of brain beta-spectrin isoform messenger RNAs.

SPTB SPTBN1

2.01e-0632921467942
Pubmed

Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice.

SPAG9 MAPK8IP3

2.01e-06329226320416
Pubmed

Spectrin deficient inherited hemolytic anemias in the mouse: characterization by spectrin synthesis and mRNA activity in reticulocytes.

IDH1 SPTB

4.02e-0642926234993
Pubmed

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.

SPTB SPTBN1

4.02e-06429221566095
Pubmed

Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.

SPTB SPTBN1

4.02e-0642923862089
Pubmed

Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.

SPTB SPTBN1

4.02e-06429221412925
Pubmed

Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein.

SPAG9 MAPK8IP3

4.02e-06429211106729
Pubmed

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.

IDH1 MTOR

4.02e-06429227624942
Pubmed

Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.

SPTB SPTBN1

4.02e-06429212820899
Pubmed

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

IKBKE MTOR

6.70e-06529221464307
Pubmed

Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance.

IKBKE MTOR

6.70e-06529223142783
Pubmed

LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins.

SPAG9 MAPK8IP3

1.00e-05629220173330
Pubmed

Fgf8 genetic labeling reveals the early specification of vestibular hair cell type in mouse utricle.

MYO7A SPTBN1

1.87e-05829233046506
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

SPAG9 SPTB SPTBN1 MAPK8IP3

2.12e-0519729436604605
Pubmed

Cell organization, growth, and neural and cardiac development require αII-spectrin.

SPTB SPTBN1

3.01e-051029222159418
Pubmed

The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration.

MYO7A SPTBN1

3.01e-051029234732824
Pubmed

Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers.

SPTBN4 SPTBN1

8.00e-051629221745462
Pubmed

Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.

SPTB SPTBN1

1.26e-042029218723693
Pubmed

A quantitative survey of gravity receptor function in mutant mouse strains.

SPTBN4 MYO7A

1.26e-042029216235133
Pubmed

Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).

SPAG9 MAPK8IP3

1.26e-042029212897243
Pubmed

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.

IDH1 MTOR NDUFS1 SPTBN1

1.26e-0431229437120454
Pubmed

Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.

SPAG9 MAPK8IP3

1.53e-042229215767678
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

SPAG9 RENBP IDH1 ARSL PKD1L3 SPTBN1

1.64e-04101629619056867
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

SPAG9 HECTD1 MTOR NDUFS1 SPTBN1

1.69e-0463829533239621
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

SERPINC1 ACTR3B MTOR NDUFS1 SPTBN1

1.80e-0464729526618866
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

SPAG9 HECTD1 MTOR NDUFS1 SPTBN1

1.88e-0465329522586326
Pubmed

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.

SPAG9 IKBKE MTOR

3.32e-0416229314743216
Pubmed

Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions.

MARK1 NDUFS1 SPTBN1

4.23e-0417629318614564
Pubmed

Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.

SPAG9 HECTD1 MAPK8IP3

4.51e-0418029330110629
Pubmed

Roles of tau protein in health and disease.

MTOR MARK1

5.13e-044029228386764
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SPTBN4 ACTR3B HECTD1 SPTB SPTBN1 MAPK8IP3

5.75e-04128529635914814
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

CUL5 ACTR3B SPRTN HECTD1 NDUFS1 TIPIN

7.03e-04133529629229926
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SPAG9 KLHL14 HECTD1 MARK1

7.15e-0449329415368895
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

SPAG9 IDH1 ACTR3B NDUFS1 SHPK

7.28e-0487829537223481
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

MYOM2 NDUFS1 SPTB SPTBN1

7.37e-0449729423414517
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

MYOM2 MYO7A IKBKE SPTBN1

7.37e-0449729436774506
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

MYO7A HECTD1 MARK1 NDUFS1

8.29e-0451329425798074
InteractionANK3 interactions

SPTBN4 SPAG9 SPTB SPTBN1 MAPK8IP3

9.18e-06201295int:ANK3
InteractionKCTD13 interactions

CUL5 SPTBN4 ACTR3B SPRTN MYO7A MARK1 NDUFS1 SPTB SPTBN1 MAPK8IP3

1.44e-0513942910int:KCTD13
Cytoband1q32.1

RHEX IKBKE

2.14e-031082921q32.1
GeneFamilyEF-hand domain containing|Spectrins

SPTBN4 SPTB SPTBN1

2.41e-0871731113
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

SPTBN4 SPTB SPTBN1

8.81e-04206173682
GeneFamilyAnkyrin repeat domain containing

ANKMY1 HECTD1

2.13e-02242172403
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RENBP IDH1 KLHDC4 MYO7A

6.20e-061862947950e03ea080238c168b9d807e217f459acdfb28
ToppCellLPS-IL1RA-Endothelial-Epi-like-Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYOM2 PKD1L3 SPTBN1

9.73e-051382935f8ac8f67e34a7cf560099208e6884102532391e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

RENBP ARSL SHPK

1.40e-041562935b2781d38a83b4b0f8a53cf321ce5db3a07d0818
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

RENBP ARSL SHPK

1.40e-04156293e0aef6104be16b12304b8e30358f444c1660e92f
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

MYOM2 MARK1 SPTB

1.51e-04160293fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYOM2 MARK1 SPTB

1.59e-0416329351dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

MYOM2 MARK1 SPTB

1.86e-04172293c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mast-Mast-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RHEX RENBP SPTB

1.90e-041732933a39c7f290a9914fcf747e6bc6f13a509413b33c
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYOM2 MARK1 SPTB

1.93e-04174293015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IDH1 KLHDC4 MYO7A

2.03e-0417729367cc3a6461db5e0678f96b18224aeb83ad34b0f4
ToppCelldroplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IDH1 KLHDC4 MYO7A

2.03e-0417729371919b5c9bfa87fdd2cd44dfa057b66ea081be5d
ToppCell10x5'-GI_large-bowel-Mast-Mast_cells|GI_large-bowel / Manually curated celltypes from each tissue

RHEX RENBP SPTB

2.06e-041782938fc5f735afa25ae43c2acb1c710ade6e9e093e3c
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-Mast_cell|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RHEX RENBP SPTB

2.06e-04178293c6704fcd21a9d2fe45679a1d998f04213b3bf224
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLHL14 PKD1L3 SPTBN1

2.06e-04178293ad3de3e03a401dac64431a541899445262246347
ToppCell10x5'-GI_large-bowel-Mast|GI_large-bowel / Manually curated celltypes from each tissue

RHEX RENBP SPTB

2.06e-04178293d10ed2543c96e1a2373f847e0b82144771e26d07
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IDH1 KLHDC4 MYO7A

2.13e-04180293cc31d2cd06161300b91b17a67bb432b75f0d719b
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IDH1 KLHDC4 MYO7A

2.20e-0418229394d061b7b5ebbfc564c644bc8b2d52341927145d
ToppCelldroplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IDH1 KLHDC4 MYO7A

2.27e-041842938fa30789c9d583188667cf375d2218e392dd40bc
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RENBP IDH1 KLHDC4

2.27e-04184293fe9ea4d0e0be820e95eaf9bb42a5560d0e177574
ToppCelldroplet-Lung-21m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IDH1 KLHDC4 MYO7A

2.27e-0418429315ea746c77785120f69f9ab370fb7eb9b70692f8
ToppCelldroplet-Lung-21m-Hematologic-myeloid-alveolar_macrophage|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IDH1 KLHDC4 MYO7A

2.27e-04184293bd5e8fc453a6393b8778734a2c3c2f1281769bcd
ToppCellCOPD-Lymphoid-B|COPD / Disease state, Lineage and Cell class

RHEX KLHL14 MAPK8IP3

2.31e-04185293925e79c35c381dd44ec5fb921dca09ce43140135
ToppCell(4)_Mast_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

RHEX RENBP SPTB

2.31e-041852933dd5d2237ab50b13a41c12f85e1b79cd72ea567b
ToppCelldroplet-Lung-LUNG-1m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IDH1 KLHDC4 MYO7A

2.31e-0418529353a5218c1e6eb12daccde3d6e02f337e2586d74c
ToppCell(4)_Mast_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

RHEX RENBP SPTB

2.31e-04185293c91e1081e630a61c18f6af6d198bfcf296746852
ToppCellCOPD-Lymphoid-B|World / Disease state, Lineage and Cell class

RHEX KLHL14 MAPK8IP3

2.31e-0418529322891ed75e25ef30dfa541cb82d85e08ce07e7d9
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLHL14 PKD1L3 SPTBN1

2.35e-0418629320340a5b5cc7f07386498a4ef937d6fbc9e347c4
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

MYOM2 MARK1 SPTB

2.38e-04187293406ff9327d3109fe1e251629c4c617b00a573dc2
ToppCelldroplet-Marrow-nan-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKBKE TIPIN SPTBN1

2.38e-0418729314c239af77116d28d511dea754b6150d20488080
ToppCell368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|368C / Donor, Lineage, Cell class and subclass (all cells)

RENBP IDH1 MYO7A

2.50e-04190293cbba3d94a4c3e0b0d14f3b7c60dba5d6e097c5e3
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYOM2 MARK1 SPTB

2.50e-04190293d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCellMesenchymal-vascular_smooth_muscle_cell|World / Lineage, Cell type, age group and donor

MYOM2 MARK1 SPTB

2.54e-04191293fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RHEX RENBP SPTB

2.58e-0419229360a02e0ccdc8c7af9bc875b248467304fe0d24a4
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MYOM2 MARK1 SPTB

2.58e-0419229355f95454399fd533df75db06584eaa48d6ee3830
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RHEX RENBP SPTB

2.58e-041922935532ea1bc012eb9303197b87e90bc39619b5ee2a
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RHEX RENBP SPTB

2.58e-04192293b223fca73e16668f69a78cf4457e349d01792540
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RHEX RENBP SPTB

2.58e-04192293b5615a780b0ba24a8e554fac9238d3f0bcba52bc
ToppCelldistal-Hematologic-Basophil/Mast_2-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RHEX RENBP SPTB

2.62e-04193293f22d0a2ea6bbdd625909ccb6a89aca89ab670306
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

MYOM2 MARK1 SPTB

2.62e-04193293360079cbaa18b74e4a48c5de40844faca076e1a6
ToppCelldistal-Hematologic-Basophil/Mast_2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RHEX RENBP SPTB

2.62e-04193293dcdc1498726c68bf590bf84cb81e5f7fb7ba4d78
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RHEX RENBP SPTB

2.62e-04193293c17e87c042ef095ac99fdd6facf3bc2886924dc4
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_granulocytic-basophil|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RHEX RENBP SPTB

2.66e-04194293aca009b9f1f320c0a65ea16df6595d7ede0b1fda
ToppCell356C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|356C / Donor, Lineage, Cell class and subclass (all cells)

RENBP IDH1 MYO7A

2.70e-041952939231e929657542b78a6480d44402866511129c7f
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

ANKMY1 MYO7A IKBKE

2.82e-041982930c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCell10x5'v1-week_17-19-Myeloid_macrophage-stroma-stromal_macrophage|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RENBP IDH1 MYO7A

2.86e-041992932649afa3ccda78e9d1df26127b66cbfa0c6cd01d
DrugADPribulose

SPTBN4 SPTB SPTBN1

5.27e-0713293CID000197570
Drugdimyristoylphosphatidylcholine

SPTBN4 MTOR SPTB SPTBN1

1.28e-0664294CID000026197
DrugMAPS

SPTBN4 RENBP MARK1 SPTB SPTBN1

3.98e-06191295CID000066161
Drugdimethyl adipimidate

SPTBN4 SPTB SPTBN1

7.37e-0630293CID000025738
DrugAC1L9K72

SPTBN4 SPAG9 HECTD1 SPTB SPTBN1

2.99e-05290295CID000446872
Drug2-nitro-5-thiocyanobenzoic acid

SPTBN4 SPTB SPTBN1

3.09e-0548293CID000092266
Drugtetrathionate

SPTBN4 RENBP SPTBN1

3.29e-0549293CID000026259
Drug1,1'-azobis(N,N-dimethylformamide

SPTBN4 NDUFS1 SPTB SPTBN1

6.59e-05173294CID000004278
DrugAC1LA5D9

HECTD1 SPTBN1

1.03e-0412292CID000462065
Drugradicicol, diheterospora chlamydosporia; Down 200; 0.1uM; HL60; HT_HG-U133A

ANKMY1 ACTR3B TIPIN MAPK8IP3

1.03e-041942946178_DN
DrugTolbutamide [64-77-7]; Down 200; 14.8uM; HL60; HT_HG-U133A

ANKMY1 SPAG9 KLHDC4 MAPK8IP3

1.05e-041952942359_DN
Drug(-)-Cinchonidine [485-71-2]; Down 200; 13.6uM; PC3; HT_HG-U133A

ACTR3B MTOR SPTBN1 MAPK8IP3

1.07e-041962945833_DN
DrugUrapidil hydrochloride [64887-14-5]; Down 200; 9.4uM; MCF7; HT_HG-U133A

TDRD7 ANKMY1 IKBKE SPTBN1

1.09e-041972946455_DN
DrugSuxibuzone [27470-51-5]; Down 200; 9.2uM; MCF7; HT_HG-U133A

TDRD7 SPAG9 SHPK SPTBN1

1.11e-041982947163_DN
DrugTerbutaline hemisulfate [23031-32-5]; Up 200; 7.2uM; MCF7; HT_HG-U133A

MYO7A MARK1 SPTB SPTBN1

1.13e-041992943202_UP
Drugikarugamycin; Down 200; 2uM; MCF7; HT_HG-U133A_EA

CUL5 ANKMY1 IKBKE MAPK8IP3

1.13e-04199294918_DN
Drugclozapine; Down 200; 10uM; MCF7; HT_HG-U133A

CUL5 ACTR3B IKBKE SPTBN1

1.16e-042002941654_DN
Diseasespinocerebellar ataxia type 5 (implicated_via_orthology)

SPTBN4 SPTB SPTBN1

3.41e-094293DOID:0050882 (implicated_via_orthology)
Diseaseradius bone mineral density

ACTR3B SPTB

5.13e-0434292EFO_0007933

Protein segments in the cluster

PeptideGeneStartEntry
DNVEEMDWMVGRILD

ARSL

321

P51690
MDWMVGRILDTLDVE

ARSL

326

P51690
EIEENMVEWLREVGM

CUL5

471

Q93034
GIIEDWDLMERFMEQ

ACTR3B

81

Q9P1U1
LQEWLDELEEMMLVV

SERPINC1

336

P01008
RLMELQEAVRWTEMI

SPAG9

521

O60271
EAVEMMDQIVHWVQE

RENBP

156

P51606
RLMELQEAVRWTEMI

MAPK8IP3

541

Q9UPT6
QELMFRGLHWVMEVL

IKBKE

436

Q14164
LMEWAENVMQIHADR

HECTD1

2141

Q9ULT8
VEMQGDEMTRIIWEL

IDH1

11

O75874
MSVLWLEHDRETRMQ

KLHL14

241

Q9P2G3
MEMILKAEEGNHEWI

ANKMY1

261

Q9P2S6
MKDRWMNVGHEEEEL

MARK1

306

Q9P0L2
LDLHRMEAWKALVEM

KLHDC4

466

Q8TBB5
WVDELFIIIMDMLQD

MTOR

816

P42345
MLTEVMEVWHGLVIA

RHEX

1

Q6ZWK4
WMHEILDMILNDGDV

SULT1C3

61

Q6IMI6
MRILPRMHEDINEEW

NDUFS1

271

P28331
VHDLMEDIEIMLWRN

PKD1L3

501

Q7Z443
VHMLVQWMADLGLEV

SHPK

331

Q9UHJ6
PWQEIHKLEVLMEEM

TDRD7

931

Q8NHU6
RDLMLWMEDVIRQIE

SPTBN1

1921

Q01082
AEVEAWLGEQELLMM

SPTBN4

1631

Q9H254
NEMWADLLELIDTRM

SPTB

1776

P11277
MDDDLMLALRLQEEW

SPRTN

1

Q9H040
EAEDLKMLIRHMEHW

TIPIN

96

Q9BVW5
NIDSLIEHMIMLWID

UGT2A2

91

P0DTE5
MVILQQGDHVWMDLR

MYO7A

1

Q13402
IQQMMEDKLAWERHT

MYOM2

131

P54296