Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoreduced fertility

ASPM CACNA1A RSPO2 ANO5 SMARCAD1 FAU XRCC5 CSGALNACT1 EHD4 FANCA

2.01e-068442710MP:0001921
MousePhenoreduced male fertility

ASPM CACNA1A ANO5 SMARCAD1 EHD4 FANCA

4.62e-05352276MP:0001922
MousePhenoperiodontium inflammation

ANO5 CSGALNACT1

5.36e-056272MP:0030132
MousePhenoabnormal chromosome stability

XRCC5 MBD1 ZSCAN5C FANCA

6.59e-05115274MP:0010094
MousePhenodecreased litter size

CACNA1A SMARCAD1 FAU XRCC5 CSGALNACT1 FANCA

7.07e-05380276MP:0001935
MousePhenoabnormal litter size

CACNA1A SMARCAD1 FAU XRCC5 CSGALNACT1 FANCA

9.27e-05399276MP:0001933
MousePhenoabnormal female reproductive system physiology

EOMES ASPM CACNA1A RSPO2 SMARCAD1 XRCC5 MBD1 FANCA

1.75e-04876278MP:0003699
MousePhenochromosome breakage

XRCC5 MBD1 FANCA

2.25e-0462273MP:0004028
MousePhenoreduced female fertility

ASPM CACNA1A RSPO2 SMARCAD1 FANCA

2.27e-04296275MP:0001923
MousePhenodecreased maxillary shelf size

RSPO2 CSGALNACT1

2.77e-0413272MP:0009897
Domain-

COL6A3 TFPI

4.01e-04183124.10.410.10
DomainPrtase_inh_Kunz-CS

COL6A3 TFPI

4.01e-0418312IPR020901
DomainKU

COL6A3 TFPI

4.01e-0418312SM00131
DomainBPTI_KUNITZ_2

COL6A3 TFPI

4.48e-0419312PS50279
DomainKunitz_BPTI

COL6A3 TFPI

4.48e-0419312PF00014
DomainBPTI_KUNITZ_1

COL6A3 TFPI

4.48e-0419312PS00280
DomainKunitz_BPTI

COL6A3 TFPI

6.60e-0423312IPR002223
DomainSNF2_N

SMARCAD1 CHD4

1.28e-0332312PF00176
DomainSNF2_N

SMARCAD1 CHD4

1.28e-0332312IPR000330
DomainChannel_four-helix_dom

CACNA1A KCNG1

4.02e-0357312IPR027359
Domain-

CACNA1A KCNG1

4.02e-03573121.20.120.350
Domain-

COL6A3 XRCC5

6.69e-03743123.40.50.410
DomainVWA

COL6A3 XRCC5

8.54e-0384312SM00327
Pubmed

The neuronal circuit between nociceptin/orphanin FQ and hypocretins/orexins coordinately modulates stress-induced analgesia and anxiety-related behavior.

HCRTR1 PNOC

4.61e-06431225677777
Pubmed

The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.

CHD4 XRCC5 NOP53

7.19e-064231334244791
Pubmed

Unified rhombic lip origins of group 3 and group 4 medulloblastoma.

EOMES RSPO2

7.68e-06531236131015
Pubmed

Analysis of Human Nuclear Protein Complexes by Quantitative Mass Spectrometry Profiling.

CHD4 XRCC5

7.68e-06531229655301
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

SRRT SMARCAD1 CHD4 XRCC5 EHD4

1.07e-0533231532786267
Pubmed

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

CHD4 URB2 XRCC5 NOP53 MBD1

1.36e-0534931525665578
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

ASPM SRRT SMARCAD1 CHD4 FAU URB2 XRCC5 EHD4

1.82e-05135331829467282
Pubmed

ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.

EOMES ASPM

2.15e-05831227562601
Pubmed

Nucleolar proteome dynamics.

CHD4 FAU URB2 XRCC5 NOP53

3.25e-0541931515635413
Pubmed

Divergent phenotypes in constitutive versus conditional mutant mouse models of Sifrim-Hitz-Weiss syndrome.

EOMES CHD4

3.44e-051031237738575
Pubmed

The transcription factor NF-YA is crucial for neural progenitor maintenance during brain development.

EOMES ASPM

4.21e-051131238199563
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

ASPM SRRT CHD4 URB2 XRCC5 NOP53

4.89e-0575931635915203
Pubmed

Dynamic SUMOylation of MORC2 orchestrates chromatin remodelling and DNA repair in response to DNA damage and drives chemoresistance in breast cancer.

CHD4 XRCC5

5.05e-051231236793866
Pubmed

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.

EOMES ASPM

5.05e-051231220823249
Pubmed

The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.

CHD4 MBD1

5.96e-051331212124384
Pubmed

Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis.

EOMES ASPM

5.96e-051331238019816
Pubmed

A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.

SRRT SNX14 BBS9

6.03e-058531323055939
Pubmed

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.

EOMES ASPM

6.95e-051431227974163
Pubmed

Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair.

XRCC5 FANCA

9.16e-051631231980815
Pubmed

A new mouse model of ARX dup24 recapitulates the patients' behavioral and fine motor alterations.

EOMES CACNA1A

9.16e-051631229659809
Pubmed

A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.

EOMES CHD4

1.04e-041731227806305
Pubmed

Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly.

EOMES ASPM

1.17e-041831228272472
Pubmed

Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias.

EOMES ASPM

1.45e-042031234237032
Pubmed

Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

SMARCAD1 CHD4 XRCC5

1.52e-0411631321549307
Pubmed

Sin3a is essential for the genome integrity and viability of pluripotent cells.

EOMES CHD4

1.92e-042331222206758
Pubmed

The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.

SRRT CHD4 FAU XRCC5

2.05e-0433031432529326
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

SRRT CHD4 FAU URB2 XRCC5 NOP53

2.09e-0498931636424410
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

SRRT SMARCAD1 CHD4 URB2 XRCC5 NOP53 EHD4

2.11e-04142531730948266
Pubmed

Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.

EOMES ASPM

2.28e-042531239271675
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

EOMES CHD4 MBD1

3.70e-0415731330186101
Pubmed

alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus.

XRCC5 FANCA

4.24e-043431216889989
Pubmed

Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

SRRT CHD4 FAU XRCC5 NOP53

4.37e-0473131529298432
Pubmed

Single-cell transcriptomic analysis of mouse neocortical development.

EOMES ASPM PNOC

4.66e-0417031330635555
Pubmed

A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation.

CHD4 XRCC5

4.75e-043631229089422
Pubmed

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.

EOMES CHD4 XRCC5

5.25e-0417731326206133
Pubmed

WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.

EOMES ASPM

5.30e-043831234059773
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

COL6A3 FAU XRCC5

5.42e-0417931336261009
Pubmed

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.

SMARCAD1 CHD4 XRCC5

5.78e-0418331336129980
Pubmed

Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.

CHD4 XRCC5

6.17e-044131215561718
Pubmed

Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

CHD4 XRCC5

6.79e-044331226030138
Pubmed

CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.

SPTLC3 SMARCAD1 FAU XRCC5

7.64e-0446831436042349
Pubmed

Directed proteomic analysis of the human nucleolus.

CHD4 URB2 NOP53

8.38e-0420831311790298
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

CHD4 URB2 XRCC5 NOP53

8.59e-0448331436912080
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

SRRT CHD4 FAU XRCC5 MBD1 FANCA

8.68e-04129431630804502
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES SMARCAD1 SLC16A2 BBS9

3.67e-06152314669d8f12fdb110ed72f4e5348b7b5350144a061c
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

RSPO2 SPTLC3 COL6A3 SLC16A2

9.24e-061923144ed5040594ba2d0639f0990697504ecef872ca70
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

RSPO2 SPTLC3 COL6A3 SLC16A2

9.24e-06192314d4f5d6653564c2c5d0f5f7c932d89cb1b1412844
ToppCellB_cell_maturation-Naive_B_cell|World / Lineage and Cell class

FAU KCNG1 NOP53 PNOC

9.24e-0619231458267a11c938a380c6e26f4e4ce63f3b4be79fdc
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RSPO2 COL6A3 CSGALNACT1 TFPI

9.63e-061943145f5f0cdeacd5e1b28717d78dabdb9eb95f661e36
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RSPO2 COL6A3 CSGALNACT1 TFPI

9.82e-0619531470387a62f121f8c374dba1aca9ab65cfed6a0b10
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature2_(2)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RSPO2 COL6A3 FAU NOP53

1.04e-0519831489e25687b614525548279e5fa293c66f5c4abec3
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature2_(2)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

RSPO2 COL6A3 FAU NOP53

1.04e-05198314a14d16d4755bd523d66e3b55e7d78cbb5359acfc
ToppCell18-Airway-Mesenchymal-Mesenchyme_RSPO2+|Airway / Age, Tissue, Lineage and Cell class

ASPM RSPO2 COL6A3 TFPI

1.06e-051993147ac35e8f45dcdc702422dabd8f3e4d03e2bf61af
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_activated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1A SPTLC3 URB2 FPR3

1.06e-051993143b2bd3caf4d189a1726a737b0121860b265eec04
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|343B / Donor, Lineage, Cell class and subclass (all cells)

SPTLC3 CSGALNACT1 FANCA

1.07e-041333138ff1cf0ea1fc33fe8384c0e65c1ee1853b25a2ae
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 CSGALNACT1 TFPI

1.19e-04138313a88c3ae56b0af60f6e87cabade4f21e2bbb336f2
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Astrocyte|GW09 / Sample Type, Dataset, Time_group, and Cell type.

KCNG1 EHD4 FANCA

1.30e-0414231385e573616e54d41391b4ad8c3d38e4ca92112673
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Thalamus / BrainAtlas - Mouse McCarroll V32

RSPO2 HCRTR1 PNOC

1.47e-04148313afebb64365c94b9476494bffe7c364677f19c8cf
ToppCellThalamus-Neuronal-Inhibitory|Thalamus / BrainAtlas - Mouse McCarroll V32

RSPO2 HCRTR1 PNOC

1.47e-041483135f82e5ecacfd223020b8ee975c17d68c1fe6db38
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-capillary_endothelial_Hpgd-CA4_high|E18.5-samps / Age Group, Lineage, Cell class and subclass

SPTLC3 TTC39C PNOC

1.65e-04154313212c340a096a3a9669d1aebd61c045cf1402a868
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-IPC_like|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

EOMES SLC16A2 CSGALNACT1

1.71e-041563137e6805ebc7bc2f9c5965321d16922c155719970f
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-IPC_like-IPs_and_early_cortical_neurons|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

EOMES SLC16A2 CSGALNACT1

1.71e-04156313741de05295b2d012ac8576378f37709a97c8fb50
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-11|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KCNG1 NOP53 PNOC

1.84e-041603138396afbc7d919ba190863d50aa0ef8b9942a9866
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 CSGALNACT1 TFPI

1.98e-041643131cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCelltumor_Lung-B_lymphocytes-Undetermined|tumor_Lung / Location, Cell class and cell subclass

FAU NOP53 PNOC

2.02e-041653133d010a66abac3961cc99f20b1459cf0eb0f7510d
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Tnaive/CM_CD8|GI_small-bowel / Manually curated celltypes from each tissue

URB2 MYCBPAP BBS9

2.13e-04168313c51244b4bdbfd961e2725306aa9cb25dd66d58bd
ToppCellLAM-Lymphoid-B-cell-1|LAM / Condition, Lineage and Cell class

FAU KCNG1 PNOC

2.20e-041703132b822a95a8d7ee193d40231418d6bd4cf9662842
ToppCell368C-Lymphocytic-ILC|368C / Donor, Lineage, Cell class and subclass (all cells)

EOMES URB2 FANCA

2.24e-041713133b3143e4aa6520ee9c6b6f2482206ad3d8205d14
ToppCell368C-Lymphocytic-ILC-ILC-2|368C / Donor, Lineage, Cell class and subclass (all cells)

EOMES URB2 FANCA

2.24e-04171313fd01076574dcc82bfd4a1538812500543b16794f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ASPM COL6A3 FANCA

2.24e-04171313b0373ed8283ee1792b6a490bff93906546978593
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ASPM COL6A3 FANCA

2.24e-04171313b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES ASPM FANCA

2.28e-0417231386f52f486d67217fc1b8443ab362c975df2974a4
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES ASPM FANCA

2.28e-04172313fb2df8fea6df5947165f13978f1d1006d15b60fd
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES ASPM FANCA

2.28e-04172313e38ebb216e4ddcd008148fcbaf709b4f3c83706a
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNG1 HCRTR1 PNOC

2.32e-04173313af85fb9f6e26a044ca4d23e5872039b1a7b73b1b
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SNX14 FANCA

2.36e-041743137be0c6248e77f2d0260b852b01e17892f7828f1b
ToppCellmild-Lymphocytic-B_cells_2|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

KCNG1 NOP53 PNOC

2.52e-04178313c6fb21401ad802a57e4e4f5a1723c42779fdb33e
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NOP53 CSGALNACT1 TTC39C

2.56e-04179313593fc323b28304a57ae162f64b0890b893fff446
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Macrophage|lymph-node_spleen / Manually curated celltypes from each tissue

ANO5 FPR3 TFPI

2.56e-04179313b4430f633711cecf793e8e76e766a66ff1eff473
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NOP53 CSGALNACT1 TTC39C

2.56e-04179313708fc0b8ffcb5fac43c52541acb6671fe1cfbb0d
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SPTLC3 CSGALNACT1 FANCA

2.61e-0418031362511d76d24b836839c3dcc2bf30485ffe9401e2
ToppCell(2)_NK/T-(230)_CD4+/CD25+_Reg_T_cell|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)

KCNG1 CSGALNACT1 TTC39C

2.65e-04181313ad14c7111d4fb924afd233cb114447f195373a7c
ToppCellBL-critical-LOC-Lymphoid-NKT|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FAU NOP53 PNOC

2.65e-04181313e3add2412c9f8eddfb77e0fbcd66fe57b23ae513
ToppCellcellseq-Immune-Lymphocytic_B-Lymphocytic_B-B|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KCNG1 NOP53 PNOC

2.69e-04182313dc6b5ce410c1a7cade60ae17cbbe8548c088cba8
ToppCellcontrol-Treg|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

NOP53 CSGALNACT1 TTC39C

2.69e-041823138e96a9dd70814cb0925776613b3a12026d455cad
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NOP53 CSGALNACT1 PNOC

2.74e-04183313ffa831f67ed005f05d1b80ebc707e046fc08e22f
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EOMES CACNA1A PNOC

2.78e-041843137d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCellBac-SEP-Lymphocyte-B-B_naive|Bac-SEP / Disease, Lineage and Cell Type

FAU KCNG1 PNOC

2.82e-041853134d9e1eeb353c0b1f82f557856e99c8bf04aa2a7f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNG1 HCRTR1 PNOC

2.82e-04185313027020754dbf71b0034791f9a34ae795e3b85f81
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNG1 HCRTR1 PNOC

2.82e-04185313487fa382232564f075960899d50afa0edae5d258
ToppCell10x5'-GI_small-bowel-Lymphocytic_B|GI_small-bowel / Manually curated celltypes from each tissue

FAU KCNG1 PNOC

2.87e-04186313a5c0bd4f6a7542f67d478dcdc0645ae6d927a395
ToppCellCOVID-19-lung-Plasmablasts|lung / Disease (COVID-19 only), tissue and cell type

ASPM FAU PNOC

2.87e-0418631381caf67da9fed09c77b7ddcab9b0b8e4fab2de97
ToppCellHealthy-MAIT|Healthy / disease group, cell group and cell class

EOMES SLC16A2 TTC39C

2.87e-04186313028061f06d86e75cb06db56b199594b80f23fa58
ToppCell343B-Lymphocytic-B_cell|343B / Donor, Lineage, Cell class and subclass (all cells)

KCNG1 NOP53 PNOC

2.87e-041863134d339d27e0aa18096554c8325107327b68511fa3
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 CSGALNACT1 TFPI

2.87e-04186313f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell343B-Lymphocytic-B_cell-|343B / Donor, Lineage, Cell class and subclass (all cells)

KCNG1 NOP53 PNOC

2.87e-04186313f76b904aa4cbbd0405bf75ffce69ddceae1af89a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ASPM COL6A3 FANCA

2.92e-04187313e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ASPM COL6A3 FANCA

2.92e-04187313cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCellNS-critical-d_16-33-Lymphoid-NKT|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EOMES FAU NOP53

2.92e-04187313dda43cc4983f1c11a2258bbce9f805db4125322c
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RSPO2 COL6A3 TFPI

2.92e-04187313a9316e2818217ec5feae9cf8816f7249803caee6
ToppCellControl-B_naive-5|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FAU KCNG1 NOP53

2.92e-041873138c48d67435e168edb892217b3f82c74f2dcedc14
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 CSGALNACT1 TFPI

2.92e-04187313c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellControl-Lymphocyte-B-B_intermediate|Control / Disease, Lineage and Cell Type

NOP53 CSGALNACT1 PNOC

2.92e-0418731390c9b1a51539838323325f563be4adf5fdf1b38f
ToppCellURO-Lymphocyte-B-B_naive|URO / Disease, Lineage and Cell Type

KCNG1 NOP53 PNOC

2.92e-041873139ed6a39aae7126ddbd01aec3376113b6b4517383
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 CSGALNACT1 TFPI

2.96e-04188313af740fa78542438fdff627ea1f74f4eee43316be
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NOP53 CSGALNACT1 TTC39C

2.96e-04188313fe08277d5aa693a2e12786738d12ec6390e8d13d
ToppCellLAM-Lymphoid-B-cell-1|Lymphoid / Condition, Lineage and Cell class

FAU KCNG1 NOP53

3.01e-04189313ceae675a769b0b01b9d0f27e9a21133959f7a7b3
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-MAIT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

EOMES FAU TTC39C

3.01e-04189313159b0979c93b7d98aaeeb43fba5983a9f67b9c9d
ToppCellCOVID_vent-Myeloid-Monocytic-SC_&_Eosinophil|COVID_vent / Disease condition, Lineage, Cell class and subclass

SPTLC3 SLC16A2 TFPI

3.01e-041893132157a2d40613f7d5ce2e7dbd266df441e449cdaf
ToppCellmetastatic_Brain-T/NK_cells-CD4+_Th|metastatic_Brain / Location, Cell class and cell subclass

FAU NOP53 TTC39C

3.01e-04189313a2b00fbe7b7b15db3fce88a56cbac0ef2917332c
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

RSPO2 COL6A3 SLC16A2

3.01e-04189313473b01c9162b12b90a617c600238436177a0d18d
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KCNG1 NOP53 PNOC

3.01e-04189313b4237437452f86e745b91285980c48a02a95f4c6
ToppCellCOVID-19-lung-Plasmablasts|COVID-19 / Disease (COVID-19 only), tissue and cell type

ASPM FAU PNOC

3.01e-04189313fdf6c945b352614885e646a5ef4bc576dee73895
ToppCellHealthy-MAIT|World / disease group, cell group and cell class

EOMES NOP53 TTC39C

3.01e-041893132404254b7a31b4a931841232e07462a3ca855ad4
ToppCellSevere-MAIT|World / Disease group and Cell class

EOMES FAU TTC39C

3.05e-041903137a92e0d6a021be23125495927b8571e25c83204a
ToppCellCOPD-Lymphoid-T_Cytotoxic|Lymphoid / Disease state, Lineage and Cell class

EOMES SRRT TTC39C

3.05e-0419031310bece40d980d37a01dae8ce887655bf9f93040c
ToppCellkidney_cells-Adult_normal_reference-Immune-Lymphocytic_T/NK-Cycling_Natural_Killer_Cell_/_Natural_Killer_T_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EOMES ASPM FANCA

3.05e-04190313b65383e256b04122500b742caeed0b807793851e
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ASPM RSPO2 PNOC

3.05e-041903138c9c230a509afaeee50644153974a5642b01a2b8
ToppCellkidney_cells-Adult_normal_reference-Immune-Lymphocytic_T/NK-Cycling_Natural_Killer_Cell_/_Natural_Killer_T_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EOMES ASPM FANCA

3.05e-0419031389095d3e023269d89c82e3a73550f869e3f34201
ToppCellSevere-MAIT|Severe / Disease group and Cell class

EOMES FAU TTC39C

3.05e-041903131c063dc1b62d9f9912aaf8d0297555a6545f5550
ToppCell(4)_B_mantle|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

FAU KCNG1 NOP53

3.10e-041913135dab7f26c59838080787efad963b9cfcfa9a5f13
ToppCellCV-Moderate-0|Moderate / Virus stimulation, Condition and Cluster

EOMES FAU NOP53

3.10e-041913136776bcc4c1915f0c1062002ff7746f20ceb725f4
ToppCelltumor_Lymph_Node_/_Brain-B_lymphocytes-Follicular_B_cells|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

FAU NOP53 PNOC

3.10e-0419131306edf2e9b50ea20060648d41fa42ee16086fdf42
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FAU KCNG1 NOP53

3.10e-04191313b374676ac90572d65895052d46469906e2b6fd93
ToppCellICU-NoSEP-Lymphocyte-B-B_naive|ICU-NoSEP / Disease, Lineage and Cell Type

KCNG1 NOP53 PNOC

3.10e-04191313f430961a94890fe8755d22e53836be39cb08e153
ToppCellmetastatic_Brain-B_lymphocytes-Follicular_B_cells|metastatic_Brain / Location, Cell class and cell subclass

FAU NOP53 PNOC

3.10e-04191313f400fce79aacf029e20b6dca59d3e17bb2375f28
ToppCellCOVID-19_Moderate-CD4+_Tcm|World / disease group, cell group and cell class

NOP53 CSGALNACT1 TTC39C

3.15e-041923135f94310f1470487816fce697ffcdc2627fc66878
ToppCellH1299-infected|H1299 / Cell line, Condition and Strain

ASPM SRRT FANCA

3.15e-041923139cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell356C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

FAU NOP53 TTC39C

3.15e-041923137aa8585e08dfbee0acbaef5f8f3817ab3ab5af25
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RSPO2 COL6A3 TFPI

3.15e-04192313ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCell356C-Lymphocytic-CD4_T-cell|356C / Donor, Lineage, Cell class and subclass (all cells)

FAU NOP53 TTC39C

3.15e-04192313badf72a52eafb0269391d907ece6b1696684adce
ToppCell10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KCNG1 NOP53 PNOC

3.15e-04192313800edadd1d1ba6b7e0a0398030dd4b61c9c480c7
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 CSGALNACT1 TFPI

3.20e-04193313ca7c0a4ceb05bced90f6cdc53d278e547fb241e9
ToppCellCD8+_Memory_T_cell-CV-0|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

EOMES FAU NOP53

3.20e-04193313995781d87a919c0380750878bafe584342bb83ad
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-B_naive-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

FAU KCNG1 PNOC

3.20e-0419331395ec708d963e9411e2dcf65650ae71a26e9d0e7f
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RSPO2 COL6A3 TFPI

3.20e-04193313b637e1c47a98009e7d19a6daac78f888fd12748f
ToppCelltumor_Lung-B_lymphocytes-Follicular_B_cells|tumor_Lung / Location, Cell class and cell subclass

FAU NOP53 PNOC

3.20e-04193313d0cb4bfc11491c903cb4cc0f823dd1ee239cf5c4
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-9|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KCNG1 NOP53 PNOC

3.20e-04193313d5d188a314da1b4c8390276d88173c09dd7ce4bf
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

RSPO2 COL6A3 TFPI

3.20e-04193313cf3cbf79ccd34ddcf06ec6194a18a7afd7f91f39
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-B_naive|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

FAU KCNG1 PNOC

3.20e-04193313d0d0835304647758e6ad4348402a4f76a76137a0
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ASPM RSPO2 PNOC

3.20e-041933135581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCellmetastatic_Lymph_Node-B_lymphocytes-Follicular_B_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

FAU NOP53 PNOC

3.25e-0419431305453f8c4d7f742b41d647d574a28555bf78ae39
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KCNG1 NOP53 PNOC

3.25e-0419431324f9de4781666c96c4a2d04f8a444543dbd99cbe
ToppCellnormal_Pleural_Fluid-B_lymphocytes|normal_Pleural_Fluid / Location, Cell class and cell subclass

FAU NOP53 PNOC

3.25e-04194313a3192698248561462d8d3bdaeabdff563a07019f
Diseaseprimary ovarian insufficiency (is_implicated_in)

BBS9 FANCA

2.79e-058302DOID:5426 (is_implicated_in)
Diseaserectum cancer (is_implicated_in)

CHD4 XRCC5

3.58e-059302DOID:1993 (is_implicated_in)
Diseasedaytime rest measurement

CACNA1A SPTLC3 HCRTR1 PNOC

2.19e-04295304EFO_0007828
DiseaseAtaxia, Spinocerebellar

CACNA1A SNX14

5.49e-0434302C0087012
DiseaseSpinocerebellar Ataxia Type 2

CACNA1A SNX14

5.49e-0434302C0752121
DiseaseSpinocerebellar Ataxia Type 1

CACNA1A SNX14

5.49e-0434302C0752120
DiseaseSpinocerebellar Ataxia Type 5

CACNA1A SNX14

5.49e-0434302C0752123
DiseaseSpinocerebellar Ataxia Type 7

CACNA1A SNX14

5.49e-0434302C0752125
DiseaseSpinocerebellar Ataxia Type 6 (disorder)

CACNA1A SNX14

5.49e-0434302C0752124
Diseasedrug dependence

ANO5 MYCBPAP

5.82e-0435302EFO_0003890
DiseaseSpinocerebellar Ataxia Type 4

CACNA1A SNX14

5.82e-0435302C0752122
DiseaseMalignant neoplasm of salivary gland

ASPM FANCA

9.63e-0445302C0220636

Protein segments in the cluster

PeptideGeneStartEntry
FNRLVFSVMREGRQK

URB2

1396

Q14146
NNFRTFFQALMLLFR

CACNA1A

1736

O00555
KQGRRMFPFLSFNIN

EOMES

291

O95936
FNLFLRRRLMFQKNQ

ANO5

51

Q75V66
KRVDKFRQFMQNFRE

CSGALNACT1

271

Q8TDX6
FNEMNSRRRKAQFFL

ARMC1

121

Q9NVT9
FLQMAVYRRRFVQQK

ASPM

2846

Q8IZT6
QRFLAQLRKYFNMRV

SLC16A2

301

P36021
QLRKYFNMRVFRQRT

SLC16A2

306

P36021
NILRDRFKSFQRRNM

NOP53

436

Q9NZM5
LYVFMGRNFQERLIR

FPR3

301

P25089
RIAFNREQRMFKRVG

MBD1

161

Q9UIS9
RKLSRFGNAFLNRFM

EHD4

126

Q9H223
KQEQERVMFRRAQFL

KCNG1

471

Q9UIX4
RNFFCLKDNGQIRFM

BBS9

266

Q3SYG4
RKLANQKRFSEFMRQ

PNOC

141

Q13519
VLNVLKRVFGMFRQA

HCRTR1

316

O43613
MFVLRGFQKNSDLRR

FANCA

241

O15360
RNTFKRVRNGFLMRK

COL6A3

2496

P12111
RVRNGFLMRKVAVFF

COL6A3

2501

P12111
FNARQRKAFLNAIMR

CHD4

1416

Q14839
IRQAMAKNRLQFVRF

LGSN

76

Q5TDP6
MNLFNLDRFRFEKRN

SMARCAD1

1

Q9H4L7
KNTRYFRQRLQEMGF

SPTLC3

436

Q9NUV7
QQKLFFFLRREGMRQ

RSPO2

56

Q6UXX9
KLDFRRQQMQDFFLA

SRRT

176

Q9BXP5
REQQDLLFRFMNFLK

SNX14

341

Q9Y5W7
KNRMQRFYFDNREGV

MYCBPAP

476

Q8TBZ2
IMKRFFFNIFTRQCE

TFPI

66

P10646
AKRRMQYNRRFVNVV

FAU

106

P62861
LFMFFKGRIQRLECQ

TTC39C

316

Q8N584
KRFMQRIGLQFHQRT

ZSCAN5C

391

A6NGD5
VQRRFFMGNQVLKVF

XRCC5

351

P13010