Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K9 demethylase activity	KDM3B KDM3A KDM4B	4.37e-06	14	47	3	GO:0032454
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM3B KDM3A KDM4B	3.84e-05	28	47	3	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM3B KDM3A KDM4B	5.25e-05	31	47	3	GO:0032452
GeneOntologyMolecularFunction	histone H3K9me/H3K9me2 demethylase activity	KDM3B KDM3A	5.40e-05	5	47	2	GO:0140683
GeneOntologyMolecularFunction	protein demethylase activity	KDM3B KDM3A KDM4B	5.78e-05	32	47	3	GO:0140457
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 3-kinase activity	PIK3CA PIK3CD	1.13e-04	7	47	2	GO:0035005
GeneOntologyMolecularFunction	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	PIK3CA PIK3CD	1.13e-04	7	47	2	GO:0046934
GeneOntologyMolecularFunction	lipid kinase activity	SPHK2 PIK3CA PIK3CD	1.22e-04	41	47	3	GO:0001727
GeneOntologyMolecularFunction	demethylase activity	KDM3B KDM3A KDM4B	1.51e-04	44	47	3	GO:0032451
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-kinase activity	PIK3CA PIK3CD	2.94e-04	11	47	2	GO:0016303
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	KDM3B KDM3A KDM4B	4.82e-04	65	47	3	GO:0016706
GeneOntologyMolecularFunction	dioxygenase activity	KDM3B KDM3A KDM4B	1.59e-03	98	47	3	GO:0051213
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIK3CA PIK3CD	1.70e-03	26	47	2	GO:0052742
GeneOntologyBiologicalProcess	protein depolymerization	SPTBN5 LIMA1 MAP2 PIK3CA VPS4A	1.87e-05	144	47	5	GO:0051261
GeneOntologyBiologicalProcess	phosphatidylinositol-mediated signaling	PLCB2 PIK3CA PIK3CD	2.17e-05	24	47	3	GO:0048015
GeneOntologyBiologicalProcess	negative regulation of protein depolymerization	SPTBN5 LIMA1 MAP2 PIK3CA	5.01e-05	89	47	4	GO:1901880
GeneOntologyBiologicalProcess	negative regulation of cytoskeleton organization	SPTBN5 LIMA1 IQCJ-SCHIP1 MAP2 PIK3CA	7.78e-05	194	47	5	GO:0051494
GeneOntologyBiologicalProcess	negative regulation of protein-containing complex disassembly	SPTBN5 LIMA1 MAP2 PIK3CA	7.91e-05	100	47	4	GO:0043242
GeneOntologyBiologicalProcess	regulation of protein depolymerization	SPTBN5 LIMA1 MAP2 PIK3CA	9.56e-05	105	47	4	GO:1901879
GeneOntologyBiologicalProcess	negative regulation of actin filament depolymerization	SPTBN5 LIMA1 PIK3CA	2.27e-04	52	47	3	GO:0030835
GeneOntologyCellularComponent	photoreceptor connecting cilium	SPTBN5 RPGRIP1 USH2A	1.61e-04	48	46	3	GO:0032391
GeneOntologyCellularComponent	phosphatidylinositol 3-kinase complex, class I	PIK3CA PIK3CD	1.69e-04	9	46	2	GO:0097651
GeneOntologyCellularComponent	phosphatidylinositol 3-kinase complex, class IA	PIK3CA PIK3CD	1.69e-04	9	46	2	GO:0005943
GeneOntologyCellularComponent	ciliary transition zone	SPTBN5 RPGRIP1 USH2A	7.55e-04	81	46	3	GO:0035869
MousePheno	abnormal body length	DOCK7 KDM3B MPLKIP PRKG2 MMP2 DIS3L2 PIK3CA KDM4B ARNT2	1.56e-05	550	39	9	MP:0001256
Domain	DUF3361	ELMO2 ELMO1	1.70e-05	3	45	2	IPR024574
Domain	DUF3361	ELMO2 ELMO1	1.70e-05	3	45	2	PF11841
Domain	PI3K_p85B	PIK3CA PIK3CD	1.70e-05	3	45	2	PF02192
Domain	PI3K_p85B	PIK3CA PIK3CD	1.70e-05	3	45	2	SM00143
Domain	JmjC	KDM3B KDM3A KDM4B	2.55e-05	24	45	3	PF02373
Domain	PI3K_ABD	PIK3CA PIK3CD	3.40e-05	4	45	2	PS51544
Domain	PI3K_adapt-bd_dom	PIK3CA PIK3CD	3.40e-05	4	45	2	IPR003113
Domain	C2_dom	RPGRIP1 PLCB2 PIK3CA PIK3CD TNS3	4.52e-05	164	45	5	IPR000008
Domain	JMJC	KDM3B KDM3A KDM4B	6.17e-05	32	45	3	PS51184
Domain	JmjC_dom	KDM3B KDM3A KDM4B	6.17e-05	32	45	3	IPR003347
Domain	JmjC	KDM3B KDM3A KDM4B	6.78e-05	33	45	3	SM00558
Domain	ELMO	ELMO2 ELMO1	8.46e-05	6	45	2	PS51335
Domain	ELMO_CED12	ELMO2 ELMO1	8.46e-05	6	45	2	PF04727
Domain	PH_12	ELMO2 ELMO1	8.46e-05	6	45	2	PF16457
Domain	ELMO_dom	ELMO2 ELMO1	8.46e-05	6	45	2	IPR006816
Domain	PI3K_Ras-bd_dom	PIK3CA PIK3CD	1.18e-04	7	45	2	IPR000341
Domain	PI3K_rbd	PIK3CA PIK3CD	1.18e-04	7	45	2	PF00794
Domain	PI3K_RBD	PIK3CA PIK3CD	1.18e-04	7	45	2	PS51546
Domain	PI3K_rbd	PIK3CA PIK3CD	1.18e-04	7	45	2	SM00144
Domain	PI3K_C2_dom	PIK3CA PIK3CD	1.57e-04	8	45	2	IPR002420
Domain	PI3K_C2	PIK3CA PIK3CD	1.57e-04	8	45	2	PF00792
Domain	PI3K_C2	PIK3CA PIK3CD	1.57e-04	8	45	2	PS51547
Domain	PI3K_C2	PIK3CA PIK3CD	1.57e-04	8	45	2	SM00142
Domain	PI3Ka	PIK3CA PIK3CD	2.02e-04	9	45	2	PF00613
Domain	-	PIK3CA PIK3CD	2.02e-04	9	45	2	1.25.40.70
Domain	PI3Ka	PIK3CA PIK3CD	2.02e-04	9	45	2	SM00145
Domain	PIK_HELICAL	PIK3CA PIK3CD	2.52e-04	10	45	2	PS51545
Domain	PI_Kinase	PIK3CA PIK3CD	2.52e-04	10	45	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3CA PIK3CD	2.52e-04	10	45	2	IPR001263
Domain	-	RPGRIP1 PLCB2 PIK3CA PIK3CD	4.38e-04	148	45	4	2.60.40.150
Domain	PI3/4_kinase_CS	PIK3CA PIK3CD	5.84e-04	15	45	2	IPR018936
Domain	-	PIK3CA PIK3CD	6.67e-04	16	45	2	1.10.1070.11
Domain	PI3Kc	PIK3CA PIK3CD	6.67e-04	16	45	2	SM00146
Domain	PI3/4_kinase_cat_dom	PIK3CA PIK3CD	8.47e-04	18	45	2	IPR000403
Domain	PI3_PI4_kinase	PIK3CA PIK3CD	8.47e-04	18	45	2	PF00454
Domain	PI3_4_KINASE_3	PIK3CA PIK3CD	8.47e-04	18	45	2	PS50290
Domain	PI3_4_KINASE_1	PIK3CA PIK3CD	8.47e-04	18	45	2	PS00915
Domain	PI3_4_KINASE_2	PIK3CA PIK3CD	8.47e-04	18	45	2	PS00916
Domain	PH_dom-like	SPTBN5 PLCB2 ELMO2 ELMO1 TNS3	3.48e-03	426	45	5	IPR011993
Domain	C2	RPGRIP1 PLCB2 PIK3CA	4.37e-03	137	45	3	SM00239
Domain	C2	RPGRIP1 PLCB2 PIK3CA	4.83e-03	142	45	3	PS50004
Domain	ARM-type_fold	PIK3CA ELMO2 PIK3CD ELMO1	8.85e-03	339	45	4	IPR016024
Pathway	REACTOME_HDMS_DEMETHYLATE_HISTONES	KDM3B KDM3A KDM4B	4.10e-05	29	33	3	MM14934
Pathway	KEGG_MEDICUS_PATHOGEN_EBV_LMP2A_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	5.29e-05	5	33	2	M48997
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPGB1_TO_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY	ELMO2 ELMO1	5.29e-05	5	33	2	M48982
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPB_TO_RHOG_SIGNALING_PATHWAY	ELMO2 ELMO1	5.29e-05	5	33	2	M48988
Pathway	KEGG_MEDICUS_PATHOGEN_EBV_LMP1_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	5.29e-05	5	33	2	M49020
Pathway	WP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION	PLCB2 PIK3CA PIK3CD	6.08e-05	33	33	3	M39745
Pathway	PID_CXCR4_PATHWAY	PLCB2 PIK3CA PIK3CD VPS4A	8.33e-05	100	33	4	M124
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	FGA SPTBN5 PRKG2 MMP2 PIK3CA RASGRP3	9.71e-05	327	33	6	M27565
Pathway	WP_KISSPEPTINKISSPEPTIN_RECEPTOR_SYSTEM_IN_THE_OVARY	PLCB2 PIK3CA PIK3CD	1.01e-04	39	33	3	M39905
Pathway	WP_NEURAL_CREST_CELL_MIGRATION_DURING_DEVELOPMENT	MMP2 PIK3CA PIK3CD	1.09e-04	40	33	3	M39798
Pathway	PID_ER_NONGENOMIC_PATHWAY	PLCB2 MMP2 PIK3CA	1.09e-04	40	33	3	M41
Pathway	KEGG_MEDICUS_REFERENCE_ACH_CHRN_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.11e-04	7	33	2	M47790
Pathway	WP_NEURAL_CREST_CELL_MIGRATION_IN_CANCER	MMP2 PIK3CA PIK3CD	1.35e-04	43	33	3	M39788
Pathway	PID_ERBB2_ERBB3_PATHWAY	DOCK7 PIK3CA PIK3CD	1.45e-04	44	33	3	M175
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.47e-04	8	33	2	M47399
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.47e-04	8	33	2	M47394
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.47e-04	8	33	2	M47395
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.47e-04	8	33	2	M47404
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.47e-04	8	33	2	M47405
Pathway	KEGG_MEDICUS_REFERENCE_P4_PR_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.47e-04	8	33	2	M47803
Pathway	KEGG_MEDICUS_VARIANT_TGFA_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.47e-04	8	33	2	M47482
Pathway	KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.47e-04	8	33	2	M47498
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_RET_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.47e-04	8	33	2	M47715
Pathway	WP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY	PLCB2 PIK3CA PIK3CD	1.66e-04	46	33	3	M48317
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.89e-04	9	33	2	M47397
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.89e-04	9	33	2	M47392
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.89e-04	9	33	2	M47391
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.89e-04	9	33	2	M47402
Pathway	KEGG_MEDICUS_REFERENCE_MEMBRANE_INITIATED_PROGESTERONE_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.89e-04	9	33	2	M47802
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_MET_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.89e-04	9	33	2	M47490
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	1.89e-04	9	33	2	M47481
Pathway	WP_PHOSPHOINOSITIDES_METABOLISM	PLCB2 PIK3CA PIK3CD	2.00e-04	49	33	3	M40046
Pathway	REACTOME_HDMS_DEMETHYLATE_HISTONES	KDM3B KDM3A KDM4B	2.13e-04	50	33	3	M27232
Pathway	KEGG_MEDICUS_VARIANT_EGFR_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	2.36e-04	10	33	2	M47400
Pathway	KEGG_MEDICUS_REFERENCE_HGF_MET_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	2.36e-04	10	33	2	M47401
Pathway	KEGG_MEDICUS_REFERENCE_CD80_CD86_CD28_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	2.36e-04	10	33	2	M47615
Pathway	KEGG_INOSITOL_PHOSPHATE_METABOLISM	PLCB2 PIK3CA PIK3CD	2.67e-04	54	33	3	M3896
Pathway	KEGG_MEDICUS_ENV_FACTOR_NICOTINE_NNK_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	2.88e-04	11	33	2	M47797
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	2.88e-04	11	33	2	M47403
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	2.88e-04	11	33	2	M47406
Pathway	KEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	2.88e-04	11	33	2	M47484
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	2.88e-04	11	33	2	M47499
Pathway	KEGG_MEDICUS_REFERENCE_NRG_ERBB4_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	2.88e-04	11	33	2	M47756
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01339	PIK3CA PIK3CD	2.88e-04	11	33	2	M47791
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	2.88e-04	11	33	2	M47501
Pathway	KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	3.46e-04	12	33	2	M47393
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01350	PIK3CA PIK3CD	3.46e-04	12	33	2	M47798
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	PIK3CA PIK3CD	3.46e-04	12	33	2	M47558
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	PIK3CA PIK3CD	3.46e-04	12	33	2	M47559
Pathway	WP_RESOLVIN_E1_AND_RESOLVIN_D1_SIGNALING_DECREASE_INFLAMMATION	PIK3CA PIK3CD	3.46e-04	12	33	2	M45559
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOINOSITIDE_3_KINASE_PI3K	PIK3CA PIK3CD	3.46e-04	12	33	2	M27905
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOINOSITIDE_3_KINASE_PI3K	PIK3CA PIK3CD	3.46e-04	12	33	2	MM15623
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	4.08e-04	13	33	2	M47398
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGF1R_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	4.08e-04	13	33	2	M47603
Pathway	REACTOME_PTK6_REGULATES_RHO_GTPASES_RAS_GTPASE_AND_MAP_KINASES	ELMO2 ELMO1	4.08e-04	13	33	2	MM15484
Pathway	REACTOME_PTK6_REGULATES_RHO_GTPASES_RAS_GTPASE_AND_MAP_KINASES	ELMO2 ELMO1	4.75e-04	14	33	2	M27734
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	4.75e-04	14	33	2	M47390
Pathway	WP_CANCER_IMMUNOTHERAPY_BY_CTLA4_BLOCKADE	PIK3CA PIK3CD	4.75e-04	14	33	2	M39840
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGFR_PI3K_NFKB_SIGNALING_PATHWAY	PIK3CA PIK3CD	4.75e-04	14	33	2	M47467
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY	PIK3CA PIK3CD	4.75e-04	14	33	2	M47536
Pathway	WP_MODULATION_OF_PI3KAKTMTOR_SIGNALING_BY_BIOACTIVE_SPHINGOLIPIDS	SPHK2 PIK3CA	4.75e-04	14	33	2	M45553
Pathway	REACTOME_SIGNALING_BY_MET	DOCK7 PIK3CA TNS3	5.06e-04	67	33	3	MM15345
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	5.47e-04	15	33	2	M47389
Pathway	KEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	5.47e-04	15	33	2	M47663
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CD	5.47e-04	15	33	2	M47475
Pathway	WP_CHEMOKINE_SIGNALING	PLCB2 PIK3CA PIK3CD ELMO1	5.68e-04	165	33	4	M39400
Pathway	KEGG_RENAL_CELL_CARCINOMA	PIK3CA PIK3CD ARNT2	5.75e-04	70	33	3	M13266
Pathway	KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY	PIK3CA PIK3CD RASGRP3	7.04e-04	75	33	3	M5436
Pathway	REACTOME_SIGNALING_BY_ERYTHROPOIETIN	PIK3CA PIK3CD	7.07e-04	17	33	2	MM15584
Pathway	SA_PTEN_PATHWAY	PIK3CA PIK3CD	7.07e-04	17	33	2	M12771
Pathway	SA_TRKA_RECEPTOR	PIK3CA PIK3CD	7.07e-04	17	33	2	M18895
Pathway	KEGG_VEGF_SIGNALING_PATHWAY	SPHK2 PIK3CA PIK3CD	7.31e-04	76	33	3	M1749
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	PLCB2 PIK3CA PIK3CD	7.31e-04	76	33	3	M9052
Pathway	REACTOME_SIGNALING_BY_MET	DOCK7 PIK3CA TNS3	8.19e-04	79	33	3	M27643
Pathway	WP_CHEMOKINE_SIGNALING_PATHWAY	PLCB2 PIK3CA PIK3CD ELMO1	8.55e-04	184	33	4	MM15943
Pathway	KEGG_CHEMOKINE_SIGNALING_PATHWAY	PLCB2 PIK3CA PIK3CD ELMO1	9.26e-04	188	33	4	M4844
Pathway	WP_CANCER_PATHWAYS	PLCB2 MMP2 PIK3CA PIK3CD RASGRP3 ARNT2	1.02e-03	507	33	6	M48302
Pathway	REACTOME_REGULATION_OF_SIGNALING_BY_CBL	PIK3CA PIK3CD	1.09e-03	21	33	2	MM15633
Pathway	REACTOME_REGULATION_OF_SIGNALING_BY_CBL	PIK3CA PIK3CD	1.19e-03	22	33	2	M903
Pathway	REACTOME_INTERLEUKIN_RECEPTOR_SHC_SIGNALING	PIK3CA PIK3CD	1.19e-03	22	33	2	MM15632
Pathway	WP_THYROID_HORMONES_PRODUCTION_AND_PERIPHERAL_DOWNSTREAM_SIGNALING_EFFECTS	KDM3B PRKG2 PIK3CA	1.31e-03	93	33	3	M39791
Pathway	KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	SPHK2 PIK3CA PIK3CD	1.44e-03	96	33	3	M16121
Pathway	WP_4HYDROXYTAMOXIFEN_DEXAMETHASONE_AND_RETINOIC_ACIDS_REGULATION_OF_P27_EXPRESSION	PIK3CA PIK3CD	1.54e-03	25	33	2	M39574
Pathway	WP_RELATIONSHIP_BETWEEN_INFLAMMATION_COX2_AND_EGFR	PIK3CA PIK3CD	1.54e-03	25	33	2	M39794
Pathway	WP_S1P_RECEPTOR_SIGNAL_TRANSDUCTION	SPHK2 PLCB2	1.54e-03	25	33	2	M39384
Pathway	REACTOME_SIGNALING_BY_ERYTHROPOIETIN	PIK3CA PIK3CD	1.54e-03	25	33	2	M27865
Pathway	WP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY	PLCB2 PIK3CA PIK3CD	1.57e-03	99	33	3	MM15905
Pathway	WP_IL3_SIGNALING_PATHWAY	MMP2 PIK3CA PIK3CD	1.62e-03	100	33	3	MM15879
Pathway	REACTOME_SIGNALING_BY_VEGF	PIK3CA ELMO2 ELMO1	1.76e-03	103	33	3	MM14752
Pathway	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	PIK3CA PIK3CD	1.80e-03	27	33	2	M1718
Pathway	REACTOME_INTERLEUKIN_RECEPTOR_SHC_SIGNALING	PIK3CA PIK3CD	1.80e-03	27	33	2	M921
Pathway	WP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY	PLCB2 PIK3CA PIK3CD	1.81e-03	104	33	3	M39625
Pathway	REACTOME_SIGNALING_BY_VEGF	PIK3CA ELMO2 ELMO1	1.91e-03	106	33	3	M27077
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY	ELMO2 ELMO1	1.93e-03	28	33	2	M47655
Pathway	PID_TRAIL_PATHWAY	PIK3CA PIK3CD	1.93e-03	28	33	2	M79
Pathway	WP_THERMOGENESIS	KDM3B KDM3A PRKG2	2.02e-03	108	33	3	M39746
Pathway	KEGG_MEDICUS_REFERENCE_PRNP_PI3K_NOX2_SIGNALING_PATHWAY	PIK3CA PIK3CD	2.07e-03	29	33	2	M47764
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPGD_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY	PIK3CA PIK3CD	2.07e-03	29	33	2	M47717
Pathway	WP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PATHWAY	PIK3CA PIK3CD	2.22e-03	30	33	2	M39592
Pathway	PID_EPHRINB_REV_PATHWAY	FGA PIK3CA	2.22e-03	30	33	2	M257
Pubmed	Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta.	MAP2 PIK3CA PIK3CD	3.79e-07	11	47	3	23077641
Pubmed	PI3 kinase alpha and delta promote hematopoietic stem cell activation.	PIK3CA PIK3CD	1.79e-06	2	47	2	31120863
Pubmed	Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.	PIK3CA PIK3CD	1.79e-06	2	47	2	24043760
Pubmed	Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.	KDM3A PIK3CA	1.79e-06	2	47	2	28692045
Pubmed	ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.	PIK3CA PIK3CD	1.79e-06	2	47	2	26883061
Pubmed	P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse.	PIK3CA PIK3CD	1.79e-06	2	47	2	23341541
Pubmed	Biased binding of class IA phosphatidyl inositol 3-kinase subunits to inducible costimulator (CD278).	PIK3CA PIK3CD	1.79e-06	2	47	2	21188463
Pubmed	PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells.	PIK3CA PIK3CD	5.36e-06	3	47	2	36812307
Pubmed	Differential distribution of ELMO1 and ELMO2 mRNAs in the developing mouse brain.	ELMO2 ELMO1	5.36e-06	3	47	2	16443196
Pubmed	The role of different PI3K protein subtypes in the metastasis, angiogenesis and clinical prognosis of hepatocellular carcinoma.	PIK3CA PIK3CD	5.36e-06	3	47	2	34023498
Pubmed	Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors.	PIK3CA PIK3CD	5.36e-06	3	47	2	20103642
Pubmed	Essential role for the p110delta phosphoinositide 3-kinase in the allergic response.	PIK3CA PIK3CD	5.36e-06	3	47	2	15496927
Pubmed	IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein.	SCHIP1 IQCJ-SCHIP1	5.36e-06	3	47	2	17045569
Pubmed	The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF.	KDM3A KDM4B	5.36e-06	3	47	2	18984585
Pubmed	A p110δ-specific inhibitor combined with bortezomib blocks drug resistance properties of EBV-related B cell origin cancer cells via regulation of NF-κB.	PIK3CA PIK3CD	5.36e-06	3	47	2	28339079
Pubmed	Targeted inhibition of dominant PI3-kinase catalytic isoforms increase expression of stem cell genes in glioblastoma cancer stem cell models.	PIK3CA PIK3CD	5.36e-06	3	47	2	27176780
Pubmed	Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas.	PIK3CA PIK3CD	5.36e-06	3	47	2	28515318
Pubmed	Class IA PI3Ks regulate subcellular and functional dynamics of IDO1.	PIK3CA PIK3CD	5.36e-06	3	47	2	33159421
Pubmed	PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML.	PIK3CA PIK3CD	5.36e-06	3	47	2	24553178
Pubmed	Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases.	PIK3CA PIK3CD	5.36e-06	3	47	2	31831213
Pubmed	Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis.	KDM3B KDM3A	1.07e-05	4	47	2	29526734
Pubmed	Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation.	KDM3B KDM3A	1.07e-05	4	47	2	23593242
Pubmed	PI 3-kinase p110beta: a new target for antithrombotic therapy.	PIK3CA PIK3CD	1.07e-05	4	47	2	15834429
Pubmed	p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes.	PIK3CA PIK3CD	1.07e-05	4	47	2	9235916
Pubmed	Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages.	PIK3CA PIK3CD	1.07e-05	4	47	2	19033389
Pubmed	Activity of any class IA PI3K isoform can sustain cell proliferation and survival.	PIK3CA PIK3CD	1.07e-05	4	47	2	20534549
Pubmed	JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor.	KDM3B KDM3A	1.07e-05	4	47	2	16603237
Pubmed	CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.	ELMO2 ELMO1	1.07e-05	4	47	2	11595183
Pubmed	G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates.	ELMO2 ELMO1	1.07e-05	4	47	2	24567399
Pubmed	Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier.	SCHIP1 IQCJ-SCHIP1	1.07e-05	4	47	2	27979964
Pubmed	Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation.	PIK3CA PIK3CD	1.07e-05	4	47	2	32414808
Pubmed	Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival.	PIK3CA PIK3CD	1.07e-05	4	47	2	23029326
Pubmed	The PI3K inhibitor arsenal: choose your weapon!	PIK3CA PIK3CD	1.07e-05	4	47	2	17920279
Pubmed	The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.	PIK3CA PIK3CD	1.07e-05	4	47	2	20699475
Pubmed	Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.	KDM3A KDM4B	1.07e-05	4	47	2	18713068
Pubmed	The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.	PIK3CA PIK3CD	1.07e-05	4	47	2	23023391
Pubmed	CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.	SCHIP1 IQCJ-SCHIP1	1.78e-05	5	47	2	25950943
Pubmed	A PI3K p110β-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis.	PIK3CA PIK3CD	1.78e-05	5	47	2	26442967
Pubmed	Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments.	SCHIP1 IQCJ-SCHIP1	1.78e-05	5	47	2	18550753
Pubmed	Identification of a novel protein interaction between Elmo1 and Cdc27.	ELMO2 ELMO1	1.78e-05	5	47	2	26882976
Pubmed	Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110δ isoform of PI 3-kinase.	PIK3CA PIK3CD	1.78e-05	5	47	2	22084313
Pubmed	Derlin-1 overexpression confers poor prognosis in muscle invasive bladder cancer and contributes to chemoresistance and invasion through PI3K/AKT and ERK/MMP signaling.	MMP2 PIK3CA	1.78e-05	5	47	2	28178653
Pubmed	TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes.	PIK3CA PIK3CD	1.78e-05	5	47	2	18590694
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DOCK7 KDM3B LIMA1 ALMS1 MAP2 ELMO2 AHNAK TNS3	1.83e-05	861	47	8	36931259
Pubmed	Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival.	PIK3CA PIK3CD	2.67e-05	6	47	2	10949031
Pubmed	Identification and characterization of JMJD2 family genes in silico.	KDM3B KDM4B	2.67e-05	6	47	2	15138608
Pubmed	Contribution of the PI3K/MMPs/Ln-5γ2 and EphA2/FAK/Paxillin signaling pathways to tumor growth and vasculogenic mimicry of gallbladder carcinomas.	MMP2 PIK3CA	2.67e-05	6	47	2	23588386
Pubmed	PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters.	PIK3CA RASGRP3	2.67e-05	6	47	2	15213298
Pubmed	Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion.	PIK3CA PIK3CD	2.67e-05	6	47	2	22972933
Pubmed	Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity.	ELMO1 TNS3	2.67e-05	6	47	2	27505886
Pubmed	The emerging mechanisms of isoform-specific PI3K signalling.	PIK3CA PIK3CD	2.67e-05	6	47	2	20379207
Pubmed	14-3-3β Promotes Migration and Invasion of Human Hepatocellular Carcinoma Cells by Modulating Expression of MMP2 and MMP9 through PI3K/Akt/NF-κB Pathway.	MMP2 PIK3CA	2.67e-05	6	47	2	26730736
Pubmed	H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline.	KDM3B KDM3A	2.67e-05	6	47	2	32679061
Pubmed	Mouse models of human ocular disease for translational research.	RPGRIP1 ALMS1	2.67e-05	6	47	2	28859131
Pubmed	Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.	PIK3CA PIK3CD	2.67e-05	6	47	2	16625210
Pubmed	Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.	KDM3B KDM3A KDM4B	2.95e-05	44	47	3	24183668
Pubmed	Comparative gene expression analysis of the engulfment and cell motility (ELMO) protein family in the mouse brain.	ELMO2 ELMO1	3.74e-05	7	47	2	31521773
Pubmed	Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.	KDM3A KDM4B	3.74e-05	7	47	2	28262558
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KDM3B KDM3A KDM4B	4.08e-05	49	47	3	34368113
Pubmed	Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity.	ZNF787 LIMA1 AHNAK	4.88e-05	52	47	3	23182705
Pubmed	Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.	PIK3CA PIK3CD	4.98e-05	8	47	2	17846664
Pubmed	VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells.	PIK3CA PIK3CD	4.98e-05	8	47	2	21540297
Pubmed	RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.	PIK3CA PIK3CD	4.98e-05	8	47	2	23706742
Pubmed	Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures.	KDM3B KDM3A KDM4B	5.17e-05	53	47	3	36265442
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	SPHK2 LIMA1 ELMO2 ZC3H13 ELMO1 RASGRP3 ARNT2	6.26e-05	750	47	7	11230166
Pubmed	Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance.	PIK3CA PIK3CD	6.40e-05	9	47	2	18367611
Pubmed	Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat.	PIK3CA PIK3CD	6.40e-05	9	47	2	21765914
Pubmed	New nomenclature for chromatin-modifying enzymes.	KDM3B KDM3A KDM4B	6.43e-05	57	47	3	18022353
Pubmed	An investigation into the human serum "interactome".	FGA GARIN5B ROBO3 TNS3	6.92e-05	162	47	4	15174051
Pubmed	P110delta, a novel phosphoinositide 3-kinase in leukocytes.	PIK3CA PIK3CD	7.99e-05	10	47	2	9113989
Pubmed	The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.	PIK3CA PIK3CD	7.99e-05	10	47	2	8636073
Pubmed	RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.	ELMO2 ELMO1	7.99e-05	10	47	2	12879077
Pubmed	Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.	PIK3CA PIK3CD	7.99e-05	10	47	2	8798481
Pubmed	Expression of HIV-1 nef decreases basal phosphatidyl-inositol 3-kinase activity.	PIK3CA PIK3CD	7.99e-05	10	47	2	9247029
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	DOCK7 KDM3B KDM3A LIMA1 ALMS1 AHNAK	9.33e-05	549	47	6	38280479
Pubmed	Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.	PIK3CA PIK3CD	9.75e-05	11	47	2	18449193
Pubmed	Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene.	PIK3CA PIK3CD	9.75e-05	11	47	2	9927325
Pubmed	HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.	PIK3CA PIK3CD	9.75e-05	11	47	2	16081599
Pubmed	HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.	PIK3CA PIK3CD	9.75e-05	11	47	2	9708406
Pubmed	HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line.	PIK3CA PIK3CD	9.75e-05	11	47	2	10985305
Pubmed	Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells.	PIK3CA PIK3CD	9.75e-05	11	47	2	12584329
Pubmed	Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity.	PIK3CA PIK3CD	9.75e-05	11	47	2	9808187
Pubmed	HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway.	PIK3CA PIK3CD	9.75e-05	11	47	2	25104021
Pubmed	Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.	PIK3CA PIK3CD	1.17e-04	12	47	2	14602571
Pubmed	Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells.	PIK3CA PIK3CD	1.17e-04	12	47	2	16514418
Pubmed	Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration.	ELMO2 ELMO1	1.17e-04	12	47	2	36400788
Pubmed	HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.	PIK3CA PIK3CD	1.17e-04	12	47	2	10208934
Pubmed	Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.	PIK3CA PIK3CD	1.17e-04	12	47	2	12077252
Pubmed	Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.	PIK3CA PIK3CD	1.17e-04	12	47	2	9341793
Pubmed	Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.	PIK3CA PIK3CD	1.17e-04	12	47	2	12551992
Pubmed	HIV-1 Nef in macrophage-mediated disease pathogenesis.	PIK3CA PIK3CD	1.38e-04	13	47	2	23215766
Pubmed	The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.	ELMO2 ELMO1	1.38e-04	13	47	2	21930703
Pubmed	Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.	PIK3CA PIK3CD	1.38e-04	13	47	2	9394803
Pubmed	Differential signaling mechanism for HIV-1 Nef-mediated production of IL-6 and IL-8 in human astrocytes.	PIK3CA PIK3CD	1.61e-04	14	47	2	26075907
Pubmed	Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.	PIK3CA PIK3CD	1.61e-04	14	47	2	17157319
Pubmed	Multiple Protein Kinases via Activation of Transcription Factors NF-κB, AP-1 and C/EBP-δ Regulate the IL-6/IL-8 Production by HIV-1 Vpr in Astrocytes.	PIK3CA PIK3CD	1.61e-04	14	47	2	26270987
Pubmed	Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.	PIK3CA PIK3CD	1.61e-04	14	47	2	20041213
Pubmed	Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays.	POLR3D PRKG2 ROBO3 MAP2	1.65e-04	203	47	4	19953087
Pubmed	HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex.	PIK3CA PIK3CD	1.86e-04	15	47	2	18854243
Pubmed	Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action.	PIK3CA PIK3CD	1.86e-04	15	47	2	20702582
Cytoband	7p14.1	MPLKIP ELMO1	3.28e-04	26	47	2	7p14.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3q25	IGSF10 SCHIP1 IQCJ-SCHIP1	8.47e-04	180	47	3	chr3q25
GeneFamily	Engulfment and cell motility proteins	ELMO2 ELMO1	9.68e-06	3	33	2	543
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM3B KDM3A KDM4B	1.09e-05	24	33	3	485
GeneFamily	Phosphatidylinositol 3-kinase subunits	PIK3CA PIK3CD	8.98e-05	8	33	2	831
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	IGSF10 ROBO3 HMCN2	3.11e-03	161	33	3	593
ToppCell	PBMC-Mild-Hematopoietic-HSPC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGSF10 SCHIP1 PRKG2 MMP2	3.78e-05	179	47	4	2f690f933bf6b99abeb31766e0b22bdbe36c1ba0
ToppCell	COVID-19_Mild-Hematopoietic_SC-HSPC\|COVID-19_Mild / Disease group, lineage and cell class	IGSF10 SCHIP1 PRKG2 MMP2	3.78e-05	179	47	4	19fcf48f5e02e4cb2b328efb4502f337e1282f72
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGSF10 SCHIP1 PRKG2 MMP2	3.78e-05	179	47	4	4bb2debfc9e9f258cd38e797ef160bd440aad6af
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGSF10 SCHIP1 PRKG2 MMP2	3.78e-05	179	47	4	3e2c937369b8190fd5d5a31689d029e6e89fb5e2
ToppCell	COVID-19_Mild-Hematopoietic_SC\|COVID-19_Mild / Disease group, lineage and cell class	IGSF10 SCHIP1 PRKG2 MMP2	3.78e-05	179	47	4	50a073166e34bcfa52a62c4dafb3aef724e0fa8e
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGSF10 SCHIP1 PRKG2 MMP2	3.95e-05	181	47	4	54a19cf6a3b752e2391feb8b316bebee0e602d17
ToppCell	PBMC-Mild-Hematopoietic-HSPC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGSF10 SCHIP1 PRKG2 MMP2	3.95e-05	181	47	4	5b84625b1d3737708001b64f6da9360330d39a27
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IGSF10 SCHIP1 PRKG2 MMP2	3.95e-05	181	47	4	e7f7b519c2a01c15f26df11ec9b434c0d1630c7a
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	PRKG2 MMP2 ELMO1 TNS3	4.03e-05	182	47	4	ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCell	Control-Hematopoietic_SC-HSPC\|Control / Disease group, lineage and cell class	IGSF10 SCHIP1 PRKG2 MMP2	4.03e-05	182	47	4	14e347c0e6444410f1948851407bb18c706569f4
ToppCell	Control-Hematopoietic_SC\|Control / Disease group, lineage and cell class	IGSF10 SCHIP1 PRKG2 MMP2	4.03e-05	182	47	4	43243c6bae2ac7fa3fd1f193a17f61ee4d938ea9
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGSF10 SCHIP1 PRKG2 MMP2	4.03e-05	182	47	4	d0ebf2f0d5370458ab81485a0017c311077133d5
ToppCell	PBMC-Control-Hematopoietic-HSPC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGSF10 SCHIP1 PRKG2 MMP2	4.03e-05	182	47	4	918286422b3eab32d962b49aa07b1b9512e51d9d
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGSF10 SCHIP1 PRKG2 MMP2	4.03e-05	182	47	4	2a6d1246bfb5899a0861c7f2f8fb9b43b0df8acc
ToppCell	COVID-19_Moderate-HSPC\|COVID-19_Moderate / disease group, cell group and cell class	IGSF10 SCHIP1 PRKG2 MMP2	4.30e-05	185	47	4	cacc6ab5f26f6c803894567fb838ea06eaa7efe5
ToppCell	hematopoetic_progenitors-CD34+_HSC\|World / Lineage and Cell class	IGSF10 PRKG2 MMP2 ELMO1	4.67e-05	189	47	4	51ff31c9cf5eff98ad01c0455dc4ae4908713575
ToppCell	Healthy-HSPC\|Healthy / disease group, cell group and cell class	IGSF10 SCHIP1 PRKG2 MMP2	4.67e-05	189	47	4	214b225effc40ca1b83dd8052f2a7b80b65d4938
ToppCell	facs-GAT-Fat-3m\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF10 ELMO2 AHNAK TM9SF3	4.77e-05	190	47	4	1d92be1b41cff59e834a9d28868f554bd1f3e471
ToppCell	10x3'2.3-week_17-19-Hematopoietic-MK-early_MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	IGSF10 LIMA1 ACOT4 RASGRP3	4.87e-05	191	47	4	3839bf57419d3ec3d4464277bb33301d2b7d701f
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IGSF10 PRKG2 MMP2 TNS3	4.97e-05	192	47	4	de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCell	PND14-Mesenchymal-Mesenchymal_structural\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IGSF10 PRKG2 MMP2 TNS3	4.97e-05	192	47	4	25492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IGSF10 PRKG2 MMP2 TNS3	5.27e-05	195	47	4	3a0cad69cfc150a27a0666f612f5294c817197d7
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IQCJ-SCHIP1 PRKG2 MAP2 TNS3	5.27e-05	195	47	4	a71ba5e4043e2d35a45a2c60a96b087e31832345
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IGSF10 PRKG2 MMP2 TNS3	5.27e-05	195	47	4	2b8ee7990267bb52b7e6ae03f509ffebf8908122
Disease	pulmonary emphysema (biomarker_via_orthology)	FGA MMP2	3.25e-05	6	44	2	DOID:9675 (biomarker_via_orthology)
Disease	keratoconus (is_marker_for)	FGA MMP2	4.54e-05	7	44	2	DOID:10126 (is_marker_for)
Disease	Adenocarcinoma Of Esophagus	PIK3CA ELMO1	1.96e-04	14	44	2	C0279628
Disease	obesity (implicated_via_orthology)	KDM3A SPHK2 PLCB2 ALMS1	2.96e-04	215	44	4	DOID:9970 (implicated_via_orthology)
Disease	eye colour measurement	IQCJ-SCHIP1 USH2A TNS3 ARNT2	3.12e-04	218	44	4	EFO_0009764
Disease	Nasopharyngeal carcinoma	MMP2 PIK3CA	4.93e-04	22	44	2	C2931822
Disease	insomnia measurement	PRKRIP1 ALMS1 MAP2 KDM4B ZNF585B	5.00e-04	443	44	5	EFO_0007876
Disease	retinitis pigmentosa (implicated_via_orthology)	RPGRIP1 USH2A	7.45e-04	27	44	2	DOID:10584 (implicated_via_orthology)
Disease	colorectal cancer (is_implicated_in)	PIK3CA PIK3CD KDM4B	7.88e-04	121	44	3	DOID:9256 (is_implicated_in)
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	KDM3A IQCJ-SCHIP1 ALMS1 USH2A ELMO1 KDM4B	1.15e-03	801	44	6	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	acute lymphoblastic leukemia (is_marker_for)	FGA KDM3B	1.18e-03	34	44	2	DOID:9952 (is_marker_for)
Disease	lymphocyte count	SPHK2 LIMA1 CALR3 ALMS1 PIK3CD AHNAK ELMO1 KDM4B	1.29e-03	1464	44	8	EFO_0004587

Protein segments in the cluster

Peptide	Gene	Start	Entry
MPPPADIVKVAIEWP	ELMO1	1	Q92556
DLDGDWPAPMLQKPP	CALR3	246	Q96L12
MEPEDLPWPGELEEE	ALMS1	1	Q8TCU4
PDVEVQGPDWHLKMP	AHNAK	1241	Q09666
PDVDVHGPDWNLKMP	AHNAK	3461	Q09666
PDVDVQGPDWHLKMP	AHNAK	3791	Q09666
GKKPELTLVWEPEDM	DIS3L2	811	Q8IYB7
IKAWPPAGMTIPEED	ARNT2	286	Q9HBZ2
DKPMGPLLVATFWPE	MMP2	501	P08253
KPSMLEDPWAGLEPV	MPLKIP	141	Q8TAP9
EEGIKMSKPKWPPED	LIMA1	546	Q9UHB6
LDPGPAKEEWNMDPL	NUDT17	306	P0C025
VPLPLVSWMKDGEPL	HMCN2	3441	Q8NDA2
EDGQPMVLKLKDWPP	KDM3B	1476	Q7LBC6
WKEPVSPMELTGPED	KDM4B	561	O94953
PEKGMPPDELSGWDK	PRKG2	746	Q13237
LVKDWPPIKPEQAME	PIK3CA	586	P42336
NPDKAVPIPEKMSEW	PRKRIP1	41	Q9H875
VALGVPKPEITWEMP	IGSF10	2551	Q6WRI0
NEKEPMVLKLKDWPP	KDM3A	1036	Q9Y4C1
SPSEKLEPWDPGMRK	C2orf83	66	Q53S99
LSPEVPLPGMKWVDN	DOCK7	701	Q96N67
MPPPSDIVKVAIEWP	ELMO2	1	Q96JJ3
TADEWAEKMPKGPPP	EFCAB6	1141	Q5THR3
LQKVPPEWKALTDMP	FGA	241	P02671
WEAGAVPAPKVPIKM	PRAP1	16	Q96NZ9
EDVPWDKMLPPKLVP	SPATA48	246	A4D263
ACIEIKWMPPEKPNG	USH2A	3881	O75445
PDVKPWLAGPKEEDM	POLR3D	196	P05423
WLAGPKEEDMEVDIP	POLR3D	201	P05423
EPPKSPEKMWPKDEN	RPGRIP1	236	Q96KN7
EPPVPPMDWEALEKH	SCHIP1	216	P0DPB3
DVCEKWGEMPPLQPK	TAF11	171	Q15544
PLEWALGVMPKPDPT	RASGRP3	401	Q8IV61
EEPPVPPMDWEALEK	IQCJ-SCHIP1	291	B3KU38
PKIMDVGWPELHAPP	TNS3	66	Q68CZ2
PGDAWKMALPAEPDP	SPTBN5	846	Q9NRC6
EPMGLLWALEPEKPF	ACOT4	76	Q8N9L9
PEMPLAWKEINDGKE	B3GALT9	316	A8MXE2
WPPTKMGLDEDNEPD	ARNTL	291	O00327
PDWEEAVKMPVGILP	SPHK2	261	Q9NRA0
LKMREDWGVSPDPPT	ROBO3	536	Q96MS0
APGFKWKPAELEPME	ZNF75CP	156	Q92670
PKPEVVMLEQGKEPW	ZNF585B	71	Q52M93
MWPSVPDEKGELLNP	PIK3CD	441	O00329
VELDCWKGKPPDEEP	PLCB2	356	Q00722
PPTPKEQKDWFIEMP	MAP2	256	P11137
PIPEKKWFMEPAVIV	TM9SF3	436	Q9HD45
KWPKVEDPMPESKVG	ZFP62	26	Q8NB50
IDVDWSGLMPKHPKE	ZC3H13	1496	Q5T200
EMTWMDVPGDKLLEP	VPS4A	386	Q9UN37
IMDDDDVPSWPPTKL	ZNF787	31	Q6DD87
KEQPWGEMKEPPWDP	GARIN5B	776	Q8N5Q1