Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncarnitine O-acyltransferase activity

CROT CPT1A

5.26e-056382GO:0016406
Domainzf-C2H2_6

TRERF1 ZNF799 ZNF556 ZNF709 PATZ1 ZNF440 ZNF669

2.37e-06314377PF13912
DomainCarn_acyltransf

CROT CPT1A

7.97e-057372PF00755
DomainACYLTRANSF_C_1

CROT CPT1A

7.97e-057372PS00439
DomainCarn_acyl_trans

CROT CPT1A

7.97e-057372IPR000542
DomainACYLTRANSF_C_2

CROT CPT1A

7.97e-057372PS00440
Domain-

TRERF1 ZNF799 ZNF556 ZNF709 PATZ1 ZNF440 ZNF669

3.23e-046793773.30.160.60
Domainzf-C2H2

TRERF1 ZNF799 ZNF556 ZNF709 PATZ1 ZNF440 ZNF669

3.66e-04693377PF00096
DomainZnf_C2H2/integrase_DNA-bd

TRERF1 ZNF799 ZNF556 ZNF709 PATZ1 ZNF440 ZNF669

3.69e-04694377IPR013087
DomainKRAB

ZNF799 ZNF556 ZNF709 ZNF440 ZNF669

6.62e-04358375PS50805
DomainKRAB

ZNF799 ZNF556 ZNF709 ZNF440 ZNF669

6.62e-04358375PF01352
DomainZINC_FINGER_C2H2_2

TRERF1 ZNF799 ZNF556 ZNF709 PATZ1 ZNF440 ZNF669

7.14e-04775377PS50157
DomainZINC_FINGER_C2H2_1

TRERF1 ZNF799 ZNF556 ZNF709 PATZ1 ZNF440 ZNF669

7.25e-04777377PS00028
DomainKRAB

ZNF799 ZNF556 ZNF709 ZNF440 ZNF669

7.59e-04369375SM00349
DomainKRAB

ZNF799 ZNF556 ZNF709 ZNF440 ZNF669

7.68e-04370375IPR001909
Domain-

SAFB2 SAFB

7.83e-04213721.10.720.30
DomainZnf_C2H2-like

TRERF1 ZNF799 ZNF556 ZNF709 PATZ1 ZNF440 ZNF669

8.36e-04796377IPR015880
DomainSAP

SAFB2 SAFB

8.60e-0422372PF02037
DomainZnf_C2H2

TRERF1 ZNF799 ZNF556 ZNF709 PATZ1 ZNF440 ZNF669

8.93e-04805377IPR007087
DomainZnF_C2H2

TRERF1 ZNF799 ZNF556 ZNF709 PATZ1 ZNF440 ZNF669

9.13e-04808377SM00355
DomainSAP

SAFB2 SAFB

9.41e-0423372SM00513
DomainSpectrin

DMD SPTA1

9.41e-0423372PF00435
DomainSAP

SAFB2 SAFB

1.11e-0325372PS50800
DomainSAP_dom

SAFB2 SAFB

1.11e-0325372IPR003034
DomainSpectrin_repeat

DMD SPTA1

1.50e-0329372IPR002017
DomainSpectrin/alpha-actinin

DMD SPTA1

1.82e-0332372IPR018159
DomainSPEC

DMD SPTA1

1.82e-0332372SM00150
DomainRRM_1

CPEB2 SAFB2 SAFB

8.01e-03208373PF00076
DomainRRM

CPEB2 SAFB2 SAFB

8.99e-03217373SM00360
DomainRRM_dom

CPEB2 SAFB2 SAFB

1.02e-02227373IPR000504
DomainRRM

CPEB2 SAFB2 SAFB

1.05e-02230373PS50102
DomainEGF_3

TENM1 NRXN1 ADAM28

1.12e-02235373PS50026
DomainEGF

TENM1 NRXN1 ADAM28

1.12e-02235373SM00181
DomainMetalloPept_cat_dom

ADAM28 MIPEP

1.12e-0281372IPR024079
Domain-

ADAM28 MIPEP

1.12e-02813723.40.390.10
Pubmed

No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p.

SAFB2 SAFB

1.16e-06238219077293
Pubmed

Low SAFB levels are associated with worse outcome in breast cancer patients.

SAFB2 SAFB

1.16e-06238219137425
Pubmed

Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?

SAFB2 SAFB

1.16e-06238214587024
Pubmed

SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells.

SAFB2 SAFB

1.16e-06238219901029
Pubmed

Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells.

SAFB2 SAFB

1.16e-06238226273616
Pubmed

Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1.

SAFB2 SAFB

1.16e-06238226092125
Pubmed

Scaffold attachment factor B (SAFB)1 and SAFB2 cooperatively inhibit the intranuclear mobility and function of ERα.

SAFB2 SAFB

1.16e-06238222566185
Pubmed

The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2.

SAFB2 SAFB

3.48e-06338219674106
Pubmed

SAFB1 interacts with and suppresses the transcriptional activity of p53.

SAFB2 SAFB

6.96e-06438221130767
Pubmed

Scaffold attachment factor SAFB1 suppresses estrogen receptor alpha-mediated transcription in part via interaction with nuclear receptor corepressor.

SAFB2 SAFB

6.96e-06438216195251
Pubmed

SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor.

SAFB2 SAFB

6.96e-06438212660241
Pubmed

Genomics of the human carnitine acyltransferase genes.

CROT CPT1A

1.74e-05638211001805
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CPEB2 PRICKLE2 DYRK1A SAFB DMD AP2B1 PCBP1 TCP1 SPTA1

1.82e-05143138937142655
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

TENM1 SAFB2 CHD2 SAFB DMD NRXN1 RIMS2 AP2B1 SPTA1

1.94e-05144238935575683
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

CPEB2 SAFB2 CHD2 SAFB NKAP PCBP1 TCP1

2.38e-0580738722681889
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

IP6K1 SAFB NKAP PCBP1 PATZ1

4.44e-0536138526167880
Pubmed

The interactome of the prostate-specific protein Anoctamin 7.

AP2B1 PCBP1 TCP1

5.02e-056538332176628
Pubmed

The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation.

DYRK1A TCP1

6.35e-051138225342745
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

DMD NRXN1 RIMS2

6.53e-057138333541421
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

SAFB2 CTU2 SAFB AP2B1 PCBP1 WEE1

7.09e-0565338633742100
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TRERF1 SAFB2 DYRK1A NRXN1 AP2B1 PCBP1 PATZ1

7.28e-0596338728671696
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

PRICKLE2 CPT1A PCBP1 TCP1 SPTA1

1.01e-0443038532581705
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

SAFB2 SAFB NKAP PCBP1

1.61e-0425138431076518
Pubmed

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.

CPEB2 CHD2

1.76e-041838230111840
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

TRERF1 SAFB2 SAFB NKAP PCBP1 WEE1

1.79e-0477438615302935
Pubmed

Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.

SAFB PCBP1 TCP1

2.66e-0411438331553912
Pubmed

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.

SAFB2 DYRK1A AP2B1

2.95e-0411838330979931
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

SAFB2 CHD2 SAFB CPT1A PCBP1 PATZ1 SPTA1

4.46e-04129438730804502
Pubmed

ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.

SAFB2 SAFB PCBP1 TCP1

4.55e-0433038433301849
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

SAFB2 CHD2 SAFB NKAP PCBP1 TCP1 POLR1H

4.97e-04131838730463901
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

DYRK1A NKAP PAN3 NRXN1 AP2B1 WEE1 PATZ1

5.04e-04132138727173435
Pubmed

Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.

DMD CILP

5.30e-043138216140986
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

DYRK1A SAFB PCBP1 TCP1

6.12e-0435738437059091
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

TRERF1 NKAP CPT1A PCBP1 PATZ1

7.00e-0465538535819319
Pubmed

Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling.

AP2B1 PCBP1 TCP1

7.29e-0416138336398662
Pubmed

An investigation into the human serum "interactome".

SAFB2 CROT DMD

7.42e-0416238315174051
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

NKAP PAN3 AP2B1 PCBP1 TCP1

8.18e-0467838530209976
Pubmed

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

AP2B1 PCBP1 TCP1 WEE1

9.43e-0440138425852190
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

SAFB2 SAFB CPT1A AP2B1 TCP1

9.49e-0470138530196744
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF799 ZNF440 ZNF669

1.02e-0318138337372979
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

SAFB AP2B1 PCBP1 PATZ1

1.03e-0341138435182466
Pubmed

CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.

AP2B1 TCP1 PATZ1

1.04e-0318238331067453
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

SAFB2 CHD2 SAFB PAN3 NRXN1 AP2B1

1.05e-03108238638697112
Pubmed

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.

SAFB2 AP2B1

1.07e-034438226471122
CytobandEnsembl 112 genes in cytogenetic band chr19p13

SAFB2 ZNF799 SAFB ZNF556 ZNF709 ZNF440

4.62e-05797386chr19p13
CytobandXq25

TENM1 TEX13C

5.36e-0441382Xq25
CytobandEnsembl 112 genes in cytogenetic band chrXq25

TENM1 TEX13C

7.35e-0448382chrXq25
Cytoband19p13.2

ZNF799 ZNF709 ZNF440

9.08e-0422938319p13.2
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF799 ZNF556 ZNF709 PATZ1 ZNF440 ZNF669

1.25e-0471821628
GeneFamilyRNA binding motif containing

CPEB2 SAFB2 SAFB

1.83e-03213213725
CoexpressionGSE22611_UNSTIM_VS_2H_MDP_STIM_MUTANT_NOD2_TRANSDUCED_HEK293T_CELL_DN

RNF144B IP6K1 PAN3 AP2B1 TCP1

6.18e-06186375M8175
ToppCellfacs-Bladder-nan-3m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF144B CROT PAN3 CPT1A WEE1

6.33e-07194385e74cd8cf3763f6adbfd1c269a886a806049714cf
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TENM1 PRICKLE2 DMD ADAM28

1.41e-05173384f8e3dded726bb3a6c24bfedf8c6732bb46262308
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TENM1 PRICKLE2 DMD ADAM28

1.54e-05177384e65c0568dc5852108e9802273499bc7cf88fafab
ToppCellPCW_10-12-Neuronal-Neuronal_postreplicative|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

NPR3 DMD NRXN1 RIMS2

1.68e-051813841aebb62ed4439db444ee9d30688212b86ee3d9ef
ToppCellPCW_10-12-Neuronal-Neuronal_postreplicative-neuro_NA|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

NPR3 DMD NRXN1 RIMS2

1.68e-051813846aee2ddee4790250ef3b2ef0038bd9839925c995
ToppCellPCW_10-12-Neuronal|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

NPR3 DMD NRXN1 RIMS2

1.68e-05181384381b553e2cae65ce6be100662a5f9f963353840c
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM1 DMD NRXN1 SPTA1

1.79e-05184384ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM1 DMD NRXN1 SPTA1

1.79e-051843842cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM1 DMD NRXN1 SPTA1

1.79e-051843842b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CPEB2 PRICKLE2 RIMS2 WEE1

1.99e-051893848c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CPEB2 PRICKLE2 RIMS2 WEE1

1.99e-051893845d902a4660a27548764bf04c6de152b565da835c
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area|World / Primary Cells by Cluster

NPR3 DMD NRXN1 RIMS2

2.34e-0519738479b9e7f2e8e33b3c547f716be5667156c48b0dfc
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area-33|World / Primary Cells by Cluster

NPR3 DMD NRXN1 RIMS2

2.34e-05197384d20f29088e9afd8a960d6f680075c380e550f8a7
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

PRICKLE2 DYRK1A DMD PAN3

2.39e-051983841996373bdccc55aac347d349bd22f6aad6d0c668
ComputationalNeighborhood of RAD21

DYRK1A PCBP1 TCP1

4.11e-0537203GCM_RAD21
ComputationalNeighborhood of DDX5

DYRK1A PCBP1 TCP1

2.24e-0465203GCM_DDX5
DrugTAT-59

SAFB2 SAFB DMD

2.37e-0616383CID003034829
Drugbutyl benzyl phthalate

SAFB2 DYRK1A SAFB

2.06e-0532383CID000002347
DrugRU 58668

TRERF1 SAFB2 SAFB

2.26e-0533383CID000119604
Diseaseautism spectrum disorder (implicated_via_orthology)

DYRK1A CHD2 NRXN1 RIMS2

3.51e-05152364DOID:0060041 (implicated_via_orthology)
Diseaseintellectual disability (is_implicated_in)

DYRK1A DMD

6.16e-0430362DOID:1059 (is_implicated_in)
DiseaseMalignant neoplasm of breast

TRERF1 TENM1 CTU2 DMD CPT1A TCP1

1.75e-031074366C0006142
Diseaseschizophrenia (implicated_via_orthology)

NRXN1 RIMS2

3.13e-0368362DOID:5419 (implicated_via_orthology)
Diseasesusceptibility to mononucleosis measurement

CPEB2 DMD

3.23e-0369362EFO_0008403
DiseaseEpilepsy, Cryptogenic

DYRK1A CHD2

4.52e-0382362C0086237
DiseaseAwakening Epilepsy

DYRK1A CHD2

4.52e-0382362C0751111
DiseaseAura

DYRK1A CHD2

4.52e-0382362C0236018
DiseaseAutism Spectrum Disorders

CHD2 NRXN1

4.85e-0385362C1510586
DiseaseNeurodevelopmental Disorders

DYRK1A CHD2

5.77e-0393362C1535926

Protein segments in the cluster

PeptideGeneStartEntry
SGTFTHRQGHIYMEM

AP2B1

726

P63010
LRVAGTMAHEMGHNF

ADAM28

331

Q9UKQ2
QHMYRLAMTGSGIDR

CPT1A

641

P50416
THEGYMMDLTAHQGR

DMD

381

P11532
YMTEGHLTMRQGADR

DYRK1A

731

Q13627
MLVAHRHGMTSGDYA

NPR3

271

P17342
MGSAGRLHYLAMTAE

RNF144B

1

Q7Z419
VARQQSHFAMMHGGT

PCBP1

241

Q15365
MHSHSTYMQARGHIV

HSFY1

301

Q96LI6
GVHMAGRTSGAHMNA

AQP7P3

81

A6NL99
MTGQMAGDHTRLEFH

NRXN1

831

Q9ULB1
DRMSYHVRSHDGSVG

PATZ1

396

Q9HBE1
MTGHYNTISRMDRHR

RIMS2

1051

Q9UQ26
HGRMHQSFDFDGGMA

PRICKLE2

636

Q7Z3G6
FHAGGETMMSRHFND

PAN3

571

Q58A45
GAMHGRDHRRTGNMG

CPEB2

141

Q7Z5Q1
MDAHRSGSYRPNNMS

CHD2

1681

O14647
FRRMSDHRPAMGYHG

CHD2

1741

O14647
HQVGGHSSMMRYDDH

IP6K1

31

Q92551
LHMARAHGYSKVMTG

CTU2

251

Q2VPK5
GYVMSGSRHRRMEAV

NKAP

351

Q8N5F7
TAMTRHFYHGRTETM

CROT

441

Q9UKG9
EHRMFMGEAYSAATG

MROH5

76

Q6ZUA9
GHEGMAYHTRQMRSA

POLR1H

91

Q9P1U0
HGRSQMESMLISGYA

TCP1

201

P17987
MHSVSRHGYQLEMGS

TENM1

91

Q9UKZ4
EGSRSMMGEREGQHY

SAFB

766

Q15424
MMGEREGQHYPERHG

SAFB

771

Q15424
RFGHVYMGNSRVSMT

CILP

506

O75339
SVRRHMVMHSGDGPY

ZNF440

186

Q8IYI8
GRGLRYIHSMSLVHM

WEE1

411

P30291
EMGHAMHSMLGRTRY

MIPEP

496

Q99797
MHSMLGRTRYQHVTG

MIPEP

501

Q99797
FRAHVMMHAGGRPYE

ZNF556

246

Q9HAH1
LGSFQRHMVMHTRDG

ZNF799

321

Q96GE5
MAMNFGDHASGFRHD

TEX13C

1

A0A0J9YWL9
GSRPMMGDHRDGQHY

SAFB2

786

Q14151
HMQQYMDPRGRSHLS

SPTA1

2391

P02549
IYHTTFRGHMRMHTG

ZNF709

206

Q8N972
GVRRHMIMHSGNPAY

ZNF669

236

Q96BR6
ALNGHMRSHGGMRAS

TRERF1

526

Q96PN7