VPS13D VPS13B

VPS13D VPS13B

VPS13D VPS13B

VPS13D VPS13B

Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis.

TSC2 PIK3C3

The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy gene.

TSC2 PKD1

Renal Neoplasia in Polycystic Kidney Disease: An Assessment of Tuberous Sclerosis Complex-associated Renal Neoplasia and PKD1/TSC2 Contiguous Gene Deletion Syndrome.

TSC2 PKD1

Two novel gross deletions of TSC2 in Malaysian patients with tuberous sclerosis complex and TSC2/PKD1 contiguous deletion syndrome.

TSC2 PKD1

Imaging features of tuberous sclerosis complex with autosomal-dominant polycystic kidney disease: a contiguous gene syndrome.

TSC2 PKD1

Acrofacial dysostosis in a patient with the TSC2-PKD1 contiguous gene syndrome.

TSC2 PKD1

Analysis of PKD1 for genomic deletion by multiplex ligation-dependent probe assay: absence of hot spots.

TSC2 PKD1

TSC2/PKD1 contiguous gene syndrome, with emphasis on a case with an atypical mild polycystic kidney phenotype and a novel genetic variant.

TSC2 PKD1

PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells.

PRKAA2 PKD1

Diagnosis and genotype-phenotype correlation in patients with PKD1/TSC2 contiguous gene deletion syndrome.

TSC2 PKD1

Polycystin 1 is required for the structural integrity of blood vessels.

TSC2 PKD1

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DNAJC13 EOGT MCM8 ZNF875 RNF213 MAPK8IP3 NDRG1 PIK3C3 TTLL11 PRKAA2 FOLH1B ZFHX3 UBE3C CATSPERG VPS13B

Concurrent Reduced Expression of Contiguous PKD1, TSC2 and NTHL1 Leading to Kidney Diseases and Multiple Diverse Renal Cancers.

TSC2 PKD1

Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis.

TSC2 PKD1

Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.

TSC2 PIK3C3

The extent of linkage disequilibrium caused by selection on G6PD in humans.

G6PD TAFAZZIN

Analysis of the human VPS13 gene family.

VPS13D VPS13B

Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR.

TSC2 PKD1

Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

TSC2 PKD1

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway.

TSC2 PKD1

LncRNA SNHG1 upregulates FANCD2 and G6PD to suppress ferroptosis by sponging miR-199a-5p/3p in hepatocellular carcinoma.

FANCD2 G6PD

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ZNF628 UBE3B TSC2 ZFPM1 MAPK8IP3 CPTP JAK3 IL17RE NBEAL2 PKD1 WDR90 UBE3C

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

TSC2 PRKAA2

VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism.

PIK3C3 UBE3C

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.

TSC2 PRKAA2

Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy.

PIK3C3 PRKAA2

Dmbx1 is a paired-box containing gene specifically expressed in the caudal most brain structures.

DMBX1 EN1

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

RNF213 BRAP UBR3 UBE3C

Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3.

TSC2 PKD1

LncRNA PVT-1 promotes osteosarcoma cancer stem-like properties through direct interaction with TRIM28 and TSC2 ubiquitination.

TSC2 PIK3C3

PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis.

PRL ARAP2

A genome-wide association study of early menopause and the combined impact of identified variants.

NLRP11 MCM8

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CLSTN3 AVL9 ADAM9 DENND4B UBE3C VPS13B ARAP2

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

NLRP11 ZFHX3 EN1

The small-subunit processome is a ribosome assembly intermediate.

NOL6 UTP20

TSC2 mediates cellular energy response to control cell growth and survival.

TSC2 PRKAA2

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

DCHS2 DMXL2 CLSTN3 CFAP91 ADAM9 TSC2 MAPK8IP3 ZNF836 NDRG1 PKD1 KCNN1 TAOK1

A comparative transcriptional map of a region of 250 kb on the human and mouse X chromosome between the G6PD and the FLN1 genes.

G6PD TAFAZZIN

Molecular neurobiology of mTOR.

TSC2 DMBX1

Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.

DMBX1 EN1

AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.

CFAP91 TMTC3 PRKAA2 ZFHX3

Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum.

DMBX1 EN1

MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy.

TSC2 PIK3C3

Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.

TSC2 NDRG1

The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity.

NLRC4 JAK3

A glycolytic shift in Schwann cells supports injured axons.

TSC2 PRKAA2

AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress.

TSC2 PRKAA2

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DOCK2 DMXL2 RNF213 ZNF836 VPS13D UBR3 TAOK1

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

DMXL2 DNAJC13 TSC2 VPS13D LRIG1 PRKAA2 VPS13B

mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

TSC2 PIK3C3

Atbf1 is required for the Pit1 gene early activation.

TBX19 ZFHX3

MCM8 interacts with DDX5 to promote R-loop resolution.

MCM8 FANCD2

Transcriptome analysis of mouse stem cells and early embryos.

POLR2B ORMDL1 CASTOR1 LRIG1 TAOK1 PRL

Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.

UBE3B PIK3C3 UBE3C

Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain.

DMBX1 EN1

Genome-wide association of serum bilirubin levels in Korean population.

DCHS2 ORMDL1

Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region.

DMBX1 EN1

Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.

DCHS2 TBX19

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

NLRP11 MCM8

Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior.

ZFPM1 EN1

Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.

IL17RE G6PD

Development of head organizer of the mouse embryo depends on a high level of mitochondrial metabolism.

CCNE2 PRKAA2

Tpit determines alternate fates during pituitary cell differentiation.

TBX19 PRL

Liganded ERα Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation.

PATZ1 UBE3C

Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.

WDR90 G6PD

Human variation in alcohol response is influenced by variation in neuronal signaling genes.

DOCK2 TSC2 PKD1 ZFHX3

UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.

RNF213 UBE3C

Embryo model completes gastrulation to neurulation and organogenesis.

DMBX1 EN1

Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.

TSC2 PKD1

Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

DOCK2 NOL6 VPS13D PIK3C3 UTP20 TAFAZZIN

Gata2, Nkx2-2 and Skor2 form a transcription factor network regulating development of a midbrain GABAergic neuron subtype with characteristics of REM-sleep regulatory neurons.

ZFPM1 EN1

Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization.

DMBX1 EN1

MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.

TBX19 PRL

The sequence and analysis of duplication-rich human chromosome 16.

TSC2 MAPK8IP3 ZFHX3

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

TMEM67 ITGA11 CLSTN3 EOGT ADAM9 RNF213 TSC2 TMTC3 UTP20 G6PD

Differentiation and molecular heterogeneity of inhibitory and excitatory neurons associated with midbrain dopaminergic nuclei.

ZFPM1 EN1

Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade.

TBX19 TAFAZZIN

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

POLR2B NOL6 RNF213 UTP20 DDX60L

Premature Expression of FOXO1 in Developing Mouse Pituitary Results in Anterior Lobe Hypoplasia.

TBX19 PRL

Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty.

TBX19 PRL

HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.

PDE1A PIK3C3

Identification of differentially expressed genes in mouse spermatogenesis.

HDAC11 ZNF836

ZNF132 ZNF628 PATZ1 ZNF875 ZFPM1 ZNF699 ZNF630 ZNF836 ZFHX3 ZNF222

DCHS2 CLSTN3

TAOK1 MAP3K2

NLRP11 NLRC4

TSC2 PKD1

JAK3 PRKAA2 WEE2

GALNTL5 ZFHX3

TSC2 NDRG1 CCNE2

TMEM67 PKD1

G6PD PRL

LINC00208 FUT6 VPS13B

LINC00208

46

CATSPERG

606

EOGT

501

BRAP

351

nan

561

CLSTN3

586

CASTOR1

106

PRKAA2

121

HDAC11

1

CCNE2

351

ARAP2

16

DMXL2

2226

LVRN

261

CFAP91

726

CFAP206

216

G6PD

116

JAK3

576

OR10V1

46

OR2B6

131

MAPK8IP3

161

LRIG1

261

NLRC4

501

MCM8

186

GLIPR1L2

96

NLRP11

181

KCNN1

461

IL17RE

371

DDX60L

271

LINC00474

51

OR2V2

216

PDE1A

221

PDE1A

286

NDRG1

201

FOLH1B

36

ZFPM1

361

MAP3K2

466

NOL6

431

GBP6

131

ITGA11

456

ORMDL1

51

EN1

371

DCHS2

1421

PATZ1

16

SERPINA2

71

DOCK2

901

ELOVL7

171

DMBX1

271

COL14A1

1631

AVL9

411

CPTP

71

GALNTL5

371

ADAM9

151

FUT6

106

ATG9B

826

DNAJC13

1721

DENND4B

791

CYP4B1

401

CCDC168

1151

FANCD2

1056

PKD1

1081

NPIPB13

601

OR2B2

131

OR10G6

151

TMEM67

836

PRL

51

SMG8

381

TIMM10B

56

UTP20

1896

TMEM184B

56

NTN5

356

NBEAL2

1596

PIK3C3

856

POLR2B

736

TAOK1

136

SF3B5

1

ARMCX1

311

C10orf62

141

PICALM

81

INPP5J

701

RNF213

1206

ZNF132

56

TTLL11

426

WDR90

691

TAFAZZIN

36

ZNF630

31

UBE3B

871

UBR3

1486

VPS13B

3626

WEE2

326

ZNF875

56

ZNF699

151

TMTC3

91

TBX19

296

VWA3A

521

ZNF836

226

ZNF222

156

TSC2

581

UBE3C

191

ZFHX3

1416

ZNF628

631

VPS13D

3856