Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	20-hydroxy-leukotriene B4 omega oxidase activity	CYP4F2 CYP4F3	3.91e-06	2	40	2	GO:0097258
GeneOntologyMolecularFunction	20-aldehyde-leukotriene B4 20-monooxygenase activity	CYP4F2 CYP4F3	3.91e-06	2	40	2	GO:0097259
GeneOntologyMolecularFunction	alpha-tocopherol omega-hydroxylase activity	CYP4F2 CYP4F3	3.90e-05	5	40	2	GO:0052871
GeneOntologyMolecularFunction	11-cis retinal binding	OPN4 OPN3	8.16e-05	7	40	2	GO:0005502
GeneOntologyMolecularFunction	sphingosine N-acyltransferase activity	CERS5 CERS6	8.16e-05	7	40	2	GO:0050291
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4F2 CYP4F3	8.16e-05	7	40	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4F2 CYP4F3	8.16e-05	7	40	2	GO:0018685
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC5A9 CACNA1E GRIN2A AQP8 ABCC2 TMEM109 NOX5 SLC2A6 MFSD3 SLC9B2	8.31e-05	1180	40	10	GO:0022857
GeneOntologyMolecularFunction	transporter activity	SLC5A9 CACNA1E GRIN2A AQP8 ABCC2 TMEM109 NOX5 SLC2A6 MFSD3 SLC9B2	1.73e-04	1289	40	10	GO:0005215
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4F2 CYP4F3	1.74e-04	10	40	2	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4F2 CYP4F3	1.74e-04	10	40	2	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4F2 CYP4F3	1.74e-04	10	40	2	GO:0102033
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4F2 CYP4F3	3.01e-04	13	40	2	GO:0016713
GeneOntologyMolecularFunction	G protein-coupled photoreceptor activity	OPN4 OPN3	4.04e-04	15	40	2	GO:0008020
GeneOntologyMolecularFunction	photoreceptor activity	OPN4 OPN3	5.22e-04	17	40	2	GO:0009881
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC5A9 CACNA1E GRIN2A AQP8 ABCC2 NOX5 SLC9B2	6.90e-04	758	40	7	GO:0015318
GeneOntologyMolecularFunction	retinal binding	OPN4 OPN3	8.02e-04	21	40	2	GO:0016918
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP4F2 CYP4F3	1.05e-03	24	40	2	GO:0008392
GeneOntologyMolecularFunction	D-glucose transmembrane transporter activity	SLC5A9 SLC2A6	1.14e-03	25	40	2	GO:0055056
GeneOntologyMolecularFunction	hexose transmembrane transporter activity	SLC5A9 SLC2A6	1.14e-03	25	40	2	GO:0015149
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP4F2 CYP4F3	1.33e-03	27	40	2	GO:0008391
GeneOntologyMolecularFunction	monosaccharide transmembrane transporter activity	SLC5A9 SLC2A6	1.33e-03	27	40	2	GO:0015145
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC5A9 CACNA1E GRIN2A AQP8 NOX5 SLC9B2	1.45e-03	627	40	6	GO:0022890
GeneOntologyMolecularFunction	sugar transmembrane transporter activity	SLC5A9 SLC2A6	1.54e-03	29	40	2	GO:0051119
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC5A9 CACNA1E GRIN2A TMEM109 NOX5 SLC9B2	1.94e-03	664	40	6	GO:0008324
GeneOntologyMolecularFunction	aromatase activity	CYP4F2 CYP4F3	2.23e-03	35	40	2	GO:0070330
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	CYP4F2 CYP4F3	2.91e-03	40	40	2	GO:0016709
GeneOntologyMolecularFunction	carbohydrate transmembrane transporter activity	SLC5A9 SLC2A6	3.20e-03	42	40	2	GO:0015144
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1E GRIN2A TMEM109	3.48e-03	152	40	3	GO:0022843
GeneOntologyMolecularFunction	heme binding	CYP4F2 CYP4F3 NOX5	3.61e-03	154	40	3	GO:0020037
GeneOntologyMolecularFunction	channel activity	CACNA1E GRIN2A AQP8 TMEM109 NOX5	3.80e-03	525	40	5	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1E GRIN2A AQP8 TMEM109 NOX5	3.83e-03	526	40	5	GO:0022803
GeneOntologyMolecularFunction	retinoid binding	OPN4 OPN3	4.16e-03	48	40	2	GO:0005501
GeneOntologyMolecularFunction	tetrapyrrole binding	CYP4F2 CYP4F3 NOX5	4.30e-03	164	40	3	GO:0046906
GeneOntologyMolecularFunction	isoprenoid binding	OPN4 OPN3	4.34e-03	49	40	2	GO:0019840
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP4F2 CYP4F3	4.34e-03	49	40	2	GO:0016712
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC5A9 CACNA1E GRIN2A TMEM109 NOX5 SLC9B2	4.66e-03	793	40	6	GO:0015075
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1E GRIN2A TMEM109 NOX5	4.80e-03	343	40	4	GO:0005261
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1E GRIN2A TMEM109	5.74e-03	182	40	3	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1E GRIN2A TMEM109	5.92e-03	184	40	3	GO:0022832
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	CYP4F2 CYP4F3 FADS3	6.85e-03	194	40	3	GO:0016705
GeneOntologyMolecularFunction	NADP binding	TM7SF2 NOX5	6.86e-03	62	40	2	GO:0050661
GeneOntologyBiologicalProcess	canalicular bile acid transport	AQP8 ABCC2	5.47e-05	6	40	2	GO:0015722
GeneOntologyBiologicalProcess	leukotriene B4 catabolic process	CYP4F2 CYP4F3	5.47e-05	6	40	2	GO:0036101
GeneOntologyBiologicalProcess	leukotriene B4 metabolic process	CYP4F2 CYP4F3	7.65e-05	7	40	2	GO:0036102
GeneOntologyBiologicalProcess	leukotriene catabolic process	CYP4F2 CYP4F3	1.02e-04	8	40	2	GO:0036100
GeneOntologyBiologicalProcess	icosanoid catabolic process	CYP4F2 CYP4F3	1.99e-04	11	40	2	GO:1901523
GeneOntologyBiologicalProcess	long-chain fatty acid catabolic process	CYP4F2 CYP4F3	2.39e-04	12	40	2	GO:0042758
GeneOntologyCellularComponent	endoplasmic reticulum membrane	PKMYT1 TM7SF2 CERS5 CYP4F2 CYP4F3 TMEM43 CERS6 GRIN2A AQP8 FADS3 GPAA1 TMEM109 CHPT1 GUCY2C NOX5 TMEM208 DDOST SLC27A3	1.33e-11	1293	42	18	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	PKMYT1 TM7SF2 CERS5 CYP4F2 CYP4F3 TMEM43 CERS6 GRIN2A AQP8 FADS3 GPAA1 TMEM109 CHPT1 GUCY2C NOX5 TMEM208 DDOST SLC27A3	1.44e-11	1299	42	18	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	PKMYT1 TM7SF2 CERS5 CYP4F2 CYP4F3 TMEM43 CERS6 GRIN2A AQP8 FADS3 GPAA1 TMEM109 CHPT1 GUCY2C NOX5 TMEM208 DDOST SLC27A3	2.05e-11	1327	42	18	GO:0042175
GeneOntologyCellularComponent	intracellular canaliculus	AQP8 ABCC2	3.93e-05	5	42	2	GO:0046691
Domain	Lag1/Lac1	CERS5 CERS6	6.67e-05	6	40	2	IPR016439
Domain	Retinal_BS	OPN4 OPN3	1.24e-04	8	40	2	IPR027430
Domain	OPSIN	OPN4 OPN3	1.99e-04	10	40	2	PS00238
Domain	Opsin	OPN4 OPN3	2.43e-04	11	40	2	IPR001760
Domain	TLC	CERS5 CERS6	5.27e-04	16	40	2	PS50922
Domain	TRAM_LAG1_CLN8	CERS5 CERS6	5.27e-04	16	40	2	PF03798
Domain	TLC-dom	CERS5 CERS6	5.27e-04	16	40	2	IPR006634
Domain	TLC	CERS5 CERS6	5.27e-04	16	40	2	SM00724
Domain	ANF_receptor	GRIN2A GUCY2C	2.84e-03	37	40	2	PF01094
Domain	ANF_lig-bd_rcpt	GRIN2A GUCY2C	2.84e-03	37	40	2	IPR001828
Domain	Peripla_BP_I	GRIN2A GUCY2C	3.15e-03	39	40	2	IPR028082
Domain	Cyt_P450_E_grp-I	CYP4F2 CYP4F3	4.18e-03	45	40	2	IPR002401
Domain	Cyt_P450_CS	CYP4F2 CYP4F3	5.75e-03	53	40	2	IPR017972
Domain	CYTOCHROME_P450	CYP4F2 CYP4F3	6.63e-03	57	40	2	PS00086
Domain	-	CYP4F2 CYP4F3	6.85e-03	58	40	2	1.10.630.10
Domain	p450	CYP4F2 CYP4F3	6.85e-03	58	40	2	PF00067
Domain	Cyt_P450	CYP4F2 CYP4F3	7.32e-03	60	40	2	IPR001128
Pathway	REACTOME_OPSINS	OPN4 OPN3	1.78e-04	9	32	2	M6285
Pathway	REACTOME_OPSINS	OPN4 OPN3	2.22e-04	10	32	2	MM15063
Pathway	REACTOME_EICOSANOIDS	CYP4F2 CYP4F3	3.25e-04	12	32	2	M27129
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4F2 CYP4F3	3.25e-04	12	32	2	M27128
Pathway	REACTOME_EICOSANOIDS	CYP4F2 CYP4F3	3.25e-04	12	32	2	MM14845
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES	CYP4F2 CYP4F3	4.47e-04	14	32	2	MM15842
Pathway	REACTOME_FATTY_ACIDS	CYP4F2 CYP4F3	5.15e-04	15	32	2	M27126
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4F2 CYP4F3	7.47e-04	18	32	2	MM14843
Pathway	REACTOME_FATTY_ACIDS	CYP4F2 CYP4F3	7.47e-04	18	32	2	MM14841
Pathway	REACTOME_CELLULAR_HEXOSE_TRANSPORT	SLC5A9 SLC2A6	8.33e-04	19	32	2	MM14718
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4F2 CYP4F3	1.02e-03	21	32	2	M27137
Pathway	REACTOME_CELLULAR_HEXOSE_TRANSPORT	SLC5A9 SLC2A6	1.02e-03	21	32	2	M27058
Pathway	WP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES	CERS5 CERS6	1.12e-03	22	32	2	M45544
Pathway	REACTOME_METABOLISM_OF_LIPIDS	TM7SF2 CERS5 CYP4F2 CYP4F3 CERS6 CHPT1 SLC27A3	1.30e-03	757	32	7	M27451
Pathway	WP_MTHFR_DEFICIENCY	GRIN2A CHPT1	1.34e-03	24	32	2	M39755
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4F2 CYP4F3	1.45e-03	25	32	2	MM14858
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	CERS5 CERS6	1.57e-03	26	32	2	M39784
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	CERS5 CERS6	1.57e-03	26	32	2	MM15892
Pathway	REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS	CERS5 CERS6	1.69e-03	27	32	2	MM14646
Pathway	REACTOME_UPTAKE_AND_ACTIONS_OF_BACTERIAL_TOXINS	ANTXR1 GUCY2C	1.95e-03	29	32	2	M27431
Pathway	WP_SPHINGOLIPID_PATHWAY	CERS5 CERS6	2.09e-03	30	32	2	M39501
Pathway	REACTOME_METABOLISM_OF_LIPIDS	TM7SF2 CERS5 CYP4F2 CYP4F3 CERS6 CHPT1	2.41e-03	620	32	6	MM15193
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX	CYP4F2 CYP4F3	2.52e-03	33	32	2	MM15918
Pathway	WP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX	CYP4F2 CYP4F3	2.52e-03	33	32	2	MM15963
Pathway	WP_ENTEROCYTE_CHOLESTEROL_METABOLISM	TM7SF2 MGAT1	3.00e-03	36	32	2	M48067
Pathway	REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS	CERS5 CERS6	3.16e-03	37	32	2	M554
Pathway	REACTOME_MATURATION_OF_SPIKE_PROTEIN	MGAT1 DDOST	3.16e-03	37	32	2	M41728
Pathway	REACTOME_DETOXIFICATION_OF_REACTIVE_OXYGEN_SPECIES	AQP8 NOX5	3.16e-03	37	32	2	M27244
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	CERS5 ANTXR1 TTC17 TMEM43 CERS6 GPAA1 TOR3A TMEM109 CHPT1 DDOST SLC27A3	1.27e-07	1201	42	11	35696571
Pubmed	A new functional motif in Hox domain-containing ceramide synthases: identification of a novel region flanking the Hox and TLC domains essential for activity.	CERS5 CERS6	1.42e-06	2	42	2	17609214
Pubmed	Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver.	CYP4F2 CYP4F3	1.42e-06	2	42	2	8026587
Pubmed	Generation of a ceramide synthase 6 mouse lacking the DDRSDIE C-terminal motif.	CERS5 CERS6	1.42e-06	2	42	2	35849604
Pubmed	Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.	CYP4F2 CYP4F3	4.27e-06	3	42	2	15145985
Pubmed	Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing.	OPN4 OPN3	4.27e-06	3	42	2	31968245
Pubmed	CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.	CERS5 CERS6	4.27e-06	3	42	2	31150623
Pubmed	Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.	CERS5 CERS6	4.27e-06	3	42	2	20406683
Pubmed	Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.	CYP4F2 CYP4F3	8.53e-06	4	42	2	18065749
Pubmed	Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.	CERS5 CERS6	8.53e-06	4	42	2	12912983
Pubmed	Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis?	CERS5 CERS6	8.53e-06	4	42	2	12297269
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	PKMYT1 ANTXR1 MGAT1 TMEM43 FADS3 GPAA1 TMEM109 CADM4 DDOST	1.10e-05	1203	42	9	29180619
Pubmed	Opsin3 Downregulation Induces Apoptosis of Human Epidermal Melanocytes via Mitochondrial Pathway.	OPN4 OPN3	1.42e-05	5	42	2	31730232
Pubmed	Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.	CERS5 CERS6	1.42e-05	5	42	2	15823095
Pubmed	Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.	CYP4F2 CYP4F3	1.42e-05	5	42	2	18577768
Pubmed	Expression of opsin genes early in ocular development of humans and mice.	OPN4 OPN3	1.42e-05	5	42	2	12573668
Pubmed	Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.	CERS5 CERS6	1.42e-05	5	42	2	26887952
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	TM7SF2 CERS6 GPAA1 CHPT1 SLC2A6 DDOST MFSD3	1.85e-05	697	42	7	28298427
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	ANTXR1 TTC17 TMEM43 FADS3 GPAA1 TOR3A TMEM109 DDOST PKP3	1.99e-05	1297	42	9	33545068
Pubmed	The cytochrome P450 4 (CYP4) family.	CYP4F2 CYP4F3	2.13e-05	6	42	2	9068972
Pubmed	Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea.	OPN4 OPN3	2.13e-05	6	42	2	32543667
Pubmed	Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.	CERS5 CERS6	2.13e-05	6	42	2	17977534
Pubmed	Oxidized phospholipids induce ceramide accumulation in RAW 264.7 macrophages: role of ceramide synthases.	CERS5 CERS6	2.13e-05	6	42	2	23936132
Pubmed	Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis.	CERS5 CERS6	3.97e-05	8	42	2	36543979
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	CERS5 MGAT1 TMEM43 FADS3 GPAA1 TOR3A TMEM109 DDOST SLC27A3	4.79e-05	1451	42	9	30550785
Pubmed	Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea.	OPN4 OPN3	5.10e-05	9	42	2	26392540
Pubmed	Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population.	GRIN2A FADS3	5.10e-05	9	42	2	25194280
Pubmed	Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.	TMEM43 GPAA1 TOR3A DDOST	5.84e-05	174	42	4	32149426
Pubmed	Opsin 3 is a key regulator of ultraviolet A-induced photoageing in human dermal fibroblast cells.	OPN4 OPN3	6.37e-05	10	42	2	31380578
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	CYP4F2 CYP4F3 ABCC2 DDOST	8.72e-05	193	42	4	19343046
Pubmed	Evolutionarily conserved regulators of tau identify targets for new therapies.	PKMYT1 TMEM43 TMEM109 DDOST SLC27A3	3.81e-04	516	42	5	36610398
Pubmed	Nutrient Transporter Gene Expression in the Early Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy.	SLC2A6 SLC27A3	4.20e-04	25	42	2	35478964
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	CERS6 FADS3 TMEM109 TMEM208	4.46e-04	296	42	4	34186245
Pubmed	Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.	CERS5 CERS6	4.90e-04	27	42	2	23096701
Pubmed	Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.	CERS5 CERS6	4.90e-04	27	42	2	25269881
Pubmed	Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.	CERS5 CERS6	5.66e-04	29	42	2	38485951
Pubmed	Comparative Multiplexed Interactomics of SARS-CoV-2 and Homologous Coronavirus Nonstructural Proteins Identifies Unique and Shared Host-Cell Dependencies.	TMEM43 DDOST	8.74e-04	36	42	2	33263384
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	CERS5 MGAT1 CERS6 TMEM109 DDOST SLC27A3	8.87e-04	942	42	6	31073040
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	TMEM207 TMEM43 ISLR NOX5 SLC27A3 FGF22	1.12e-03	985	42	6	12975309
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	TMEM43 TOR3A TMEM109 CHPT1 DDOST	1.13e-03	657	42	5	36180527
Interaction	TMEM106B interactions	ANTXR1 TTC17 TMEM43 GPAA1 TOR3A TMEM109 DDOST	2.68e-06	309	41	7	int:TMEM106B
Interaction	FPR2 interactions	CERS5 CERS6 GPAA1 CHPT1 TMEM208	8.60e-06	138	41	5	int:FPR2
Interaction	PGRMC2 interactions	CYP4F2 FADS3 TMEM109 TMEM208 DDOST SLC9B2	2.08e-05	281	41	6	int:PGRMC2
Interaction	CYP26B1 interactions	PKMYT1 ABCC2 SLC27A3	3.05e-05	30	41	3	int:CYP26B1
Interaction	TCTN3 interactions	TMEM43 ISLR GPAA1 TMEM109 CHPT1 DDOST	5.46e-05	334	41	6	int:TCTN3
Interaction	TLCD3A interactions	PKMYT1 TOR3A SLC27A3	6.27e-05	38	41	3	int:TLCD3A
Interaction	SPPL2B interactions	TMEM43 CERS6 GPAA1 CHPT1 CADM4	1.06e-04	233	41	5	int:SPPL2B
GeneFamily	CERS class homeoboxes	CERS5 CERS6	3.98e-05	6	30	2	530
GeneFamily	Opsin receptors	OPN4 OPN3	1.45e-04	11	30	2	215
GeneFamily	Cytochrome P450 family 4	CYP4F2 CYP4F3	1.62e-03	36	30	2	1003
GeneFamily	Solute carriers	SLC5A9 SLC2A6 SLC27A3 SLC9B2	3.92e-03	395	30	4	752
Coexpression	CHEN_METABOLIC_SYNDROM_NETWORK	PKMYT1 CERS5 ANTXR1 CYP4F2 CYP4F3 TMEM43 CERS6 FADS3 CTC1 OPN3 SLC2A6 SLC27A3	3.58e-07	1242	42	12	M1920
Coexpression	CHEN_METABOLIC_SYNDROM_NETWORK	PKMYT1 CERS5 ANTXR1 CYP4F2 TMEM43 CERS6 FADS3 CTC1 OPN3 SLC2A6 SLC27A3	4.97e-06	1316	42	11	MM1052
Coexpression	NUTT_GBM_VS_AO_GLIOMA_UP	FADS3 TMEM109 DDOST	5.54e-05	46	42	3	M6921
Coexpression	KOYAMA_SEMA3B_TARGETS_UP	TM7SF2 ANTXR1 TTC17 PKP3 SLC27A3	6.72e-05	268	42	5	M12746
Coexpression	STK33_DN	CYP4F2 CYP4F3 CHPT1 MFSD3 SLC9B2	8.26e-05	280	42	5	M2853
CoexpressionAtlas	DevelopingKidney_e15.5_early proxim tubul_emap-28005_top-relative-expression-ranked_1000	TM7SF2 SLC5A9 MGAT1 AQP8 FADS3 ABCC2 TOR3A CHPT1 MFSD3	1.82e-05	784	42	9	gudmap_developingKidney_e15.5_early proxim tubul_1000
ToppCell	TCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma_Heterologous_Type-3\|TCGA-Uterus / Sample_Type by Project: Shred V9	SLC5A9 TMEM207 GRIN2A GUCY2C	9.97e-06	143	42	4	bcf702f976ab91f82a5a4beb0b7c74a372c42ae6
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TOR3A GUCY2C OPN3 SLC2A6	1.55e-05	160	42	4	5d8d97c3da5837ba5fe743d2f8438f5cb7cea64b
ToppCell	P07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CERS6 ISLR FREM1 SLC27A3	1.59e-05	161	42	4	b19f82dd98a3064581793711bb70373f18abecd9
ToppCell	CF-Myeloid-cDC\|CF / Disease state, Lineage and Cell class	CERS6 TOR3A NPFFR1 OPN3	2.74e-05	185	42	4	7f3d118845ff9f5f525796b0bbc6532a8ee323ab
ToppCell	proximal-Hematologic-Plasmacytoid_Dendritic\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CERS6 ABCC2 OPN3 CADM4	3.17e-05	192	42	4	faead5875a54fe8f1848ae36008aae4c0f7cb1c7
ToppCell	proximal-3-Hematologic-Plasmacytoid_Dendritic\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CERS6 ABCC2 OPN3 CADM4	3.17e-05	192	42	4	86938c7d2bb1a7afb2b83828ca33dd137d366ec6
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CERS6 ISLR FREM1 SLC27A3	3.17e-05	192	42	4	0afb9dbe468e0be442c326e11c5fc0f699b32f23
ToppCell	proximal-Hematologic-Plasmacytoid_Dendritic-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CERS6 ABCC2 OPN3 CADM4	3.17e-05	192	42	4	e3be395a995dc8c0ebdae754057cfa59a270cae0
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PKMYT1 TOR3A TMEM208 DDOST	3.23e-05	193	42	4	22684aa2a368211baba79d29379d0bc442830524
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PKMYT1 TOR3A TMEM208 DDOST	3.30e-05	194	42	4	ffba703f61faaac8b4b9a5e46cd335214303de7b
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC5A9 CHPT1 GUCY2C SLC2A6	3.37e-05	195	42	4	e87b11e3242fdbed2e7f383e6876ec375af32bd4
ToppCell	COVID-19-COVID-19_Severe-Myeloid-pDC\|COVID-19_Severe / Disease, condition lineage and cell class	CERS6 TMEM109 OPN3 CADM4	3.57e-05	198	42	4	033ed362333e1d33f2aeea8da5865d2228d154dc
ToppCell	TCGA-Endometrium-Primary_Tumor\|TCGA-Endometrium / Sample_Type by Project: Shred V9	PKMYT1 TM7SF2 PKP3 MFSD3	3.72e-05	200	42	4	1cbb62df4ea1631fef8497e1702175605d0869e7
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-Unfolded_protein_responsible_cell\|6m / Sample Type, Dataset, Time_group, and Cell type.	SLC5A9 ABCC2 GUCY2C PKP3	3.72e-05	200	42	4	12078bc25be67180c0f4b37fef921cdcd1003576
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma\|TCGA-Endometrium / Sample_Type by Project: Shred V9	PKMYT1 TM7SF2 PKP3 MFSD3	3.72e-05	200	42	4	e3ad8d592686a5d1e1fb8dd05c2f00eac4c5738f
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Sncg_(Neuron.Gad1Gad2.Synpr-Sncg)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	OPN4 NPFFR1 FREM1	4.68e-05	74	42	3	a7f7ed7316c226e18ee62d0149be7404326817c6
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Sncg_(Neuron.Gad1Gad2.Synpr-Sncg)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	OPN4 NPFFR1 FREM1	4.68e-05	74	42	3	216721986c3055f2d9b4702be9693b3a0892283c
ToppCell	Control-Neutrophil\|Control / Disease condition and Cell class	CACNA1E CYP4F2 CYP4F3	2.27e-04	126	42	3	450c01d89714feee6529680ec3ce69067a54b37c
ToppCell	Control-Neutrophil-\|Control / Disease condition and Cell class	CACNA1E CYP4F2 CYP4F3	2.27e-04	126	42	3	65fff5ec2296272e94f44546606587833191dd82
ToppCell	facs-Aorta-Heart-3m-Endothelial-coronary_vascular_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHA5 ABCC2 NODAL	2.61e-04	132	42	3	dc13b54e38fbda9341972cef11833041f2f2a345
ToppCell	356C-Epithelial_cells-Epithelial-E_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ABCC2 NPFFR1 MIEF2	3.16e-04	141	42	3	31e0984f09983e83a814424f74c871c1c5a3a789
ToppCell	356C-Epithelial_cells-Epithelial-E_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ABCC2 NPFFR1 MIEF2	3.16e-04	141	42	3	d7d3c3932651d90fa4f3c4e3df16f4b677faaf9f
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CYP4F2 CERS6 GPAA1	3.43e-04	145	42	3	47a3bb973a508d3097213a2d86ad1ce697af9bae
ToppCell	Pericytes-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	ANTXR1 ISLR DDOST	3.79e-04	150	42	3	dbc202bd6db4fb5c8b2abd1200e074a2a9e63a59
ToppCell	facs-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TM7SF2 AQP8 ABCC2	4.25e-04	156	42	3	e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TMEM109 NPFFR1 OPN3	4.25e-04	156	42	3	0f54d62c0fc08bbdd5ac743b2d5d748c3d1e6ef9
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E FADS3 PKP3	4.33e-04	157	42	3	fc127e7720649e746f3d3f5c2e9e63784767106a
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E FADS3 PKP3	4.33e-04	157	42	3	66a191cef4aa00811bb04462310d012610006f85
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E PKP3 SLC27A3	4.58e-04	160	42	3	e9e52532131cdc3fb01e81cfc046e3f670cc8e75
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TOR3A SLC2A6 CADM4	4.66e-04	161	42	3	63f0b97c741b610c450f65fa5764d712bfe09ce8
ToppCell	droplet-Heart-nan-24m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY2C SLC2A6 PKP3	4.66e-04	161	42	3	7e60001637ef0f6fc67ef8a36ab80ebb25b0b0ab
ToppCell	droplet-Marrow-BM-30m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E CERS6 SLC2A6	4.75e-04	162	42	3	75df7ff779a3b9159ba97d852da1f8df650b9ce5
ToppCell	5'-Adult-Appendix-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC2A6 CADM4 SLC27A3	4.75e-04	162	42	3	ded08da888d8c481f0f96d1e0bfd03d617966910
ToppCell	droplet-Lung-3m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E GUCY2C PKP3	4.92e-04	164	42	3	cfe07a1ebed8aecb08d0476db71fe314998d54aa
ToppCell	droplet-Lung-3m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E GUCY2C PKP3	4.92e-04	164	42	3	6d331e74efecb4733d87653f86cd67247be05025
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CACNA1E TMEM207 GUCY2C	5.09e-04	166	42	3	6a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal-Basal-Basal_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC5A9 CADM4 PKP3	5.18e-04	167	42	3	29d271643f3a1718b53db77b7d093ec94225a824
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-double_negative_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TM7SF2 SLC27A3 SLC9B2	5.27e-04	168	42	3	de1042267407719f19eb3f580a5df0c9cd0e8273
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP4F2 CYP4F3 GUCY2C	5.27e-04	168	42	3	0f736d58cb0ff042fa3ce58e36bde37b6976f8fc
ToppCell	facs-Heart-LV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANTXR1 ISLR NPFFR1	5.37e-04	169	42	3	849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GRIN2A FREM1 SLC27A3	5.46e-04	170	42	3	7fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCell	droplet-Lung-30m-Hematologic-myeloid-classical_monocyte_proliferating-\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PKMYT1 GUCY2C SLC27A3	5.55e-04	171	42	3	1efce222989460bb59bd9fa955e7d9a60c73994c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E CYP4F3 ABCC2	5.55e-04	171	42	3	f5014e3c387fe3118944af392abe10d6b9b0abab
ToppCell	droplet-Lung-nan-3m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E GUCY2C PKP3	5.74e-04	173	42	3	1b9b4e165121b08ef15a93fca6bea875cae69f19
ToppCell	droplet-Lung-nan-3m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E GUCY2C PKP3	5.74e-04	173	42	3	c25f24d7b672c9686d31ebc8d263042282f520fd
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E CYP4F3 ABCC2	5.74e-04	173	42	3	8888434641ea554a9b62c436e87920378eef29cd
ToppCell	control-Lymphocytic-B_cells_2\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CHPT1 OPN3 PKP3	5.74e-04	173	42	3	95af11b7d6c7dcd470943e5bdc56bed7a134e358
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Lymphocytic-T\|bone_marrow / Manually curated celltypes from each tissue	PKMYT1 SLC5A9 PKP3	5.84e-04	174	42	3	1e289b26e2c29dbad15b712a999b96c391a26129
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1E CYP4F3 GUCY2C	5.84e-04	174	42	3	3503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANTXR1 ISLR NPFFR1	6.04e-04	176	42	3	f25251abd4ef9fb077a978f9f9f658af58e4e0d2
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANTXR1 ISLR NPFFR1	6.04e-04	176	42	3	fee4e0f32aaf77294040c7af6c1f503571750d43
ToppCell	COVID-19-kidney-PCT-S1/S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1E CYP4F3 ABCC2	6.24e-04	178	42	3	23a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCell	ILEUM-non-inflamed-(5)_Plasmablasts\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PKMYT1 TMEM208 DDOST	6.34e-04	179	42	3	58c8996120637315dcbd1991a71516c09173051e
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAT1 FADS3 PKP3	6.34e-04	179	42	3	1757b9f3f4c634277a67c4f5a39d27d6b4937073
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANTXR1 GRIN2A ISLR	6.45e-04	180	42	3	935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCell	5'-Airway_Nasal-Mesenchymal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANTXR1 GRIN2A ISLR	6.45e-04	180	42	3	3dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCell	COVID-19-kidney-tDL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1E CYP4F3 ABCC2	6.45e-04	180	42	3	864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-1\|TCGA-Lung / Sample_Type by Project: Shred V9	ABCC2 TMEM208 OPN3	6.55e-04	181	42	3	78b646feca39d1bfd68f9843b7f557b3fac56829
ToppCell	COVID-19-kidney-Stressed_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1E CYP4F3 ABCC2	6.55e-04	181	42	3	6980ea624151da32b7f537f263e40fcb87a02e81
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANTXR1 GRIN2A ISLR	6.76e-04	183	42	3	6d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CYP4F2 CYP4F3 ABCC2	6.76e-04	183	42	3	facd6dbe0851b537d70a899ac7485714ab27d071
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A9 CYP4F3 ABCC2	6.76e-04	183	42	3	84b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANTXR1 GRIN2A ISLR	6.76e-04	183	42	3	cc7f5a17b40e8d901885174922e5fa8877643071
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANTXR1 GRIN2A ISLR	6.76e-04	183	42	3	803376f5260de83c48d4f7301278d078a32b3e6e
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ISLR FADS3 SLC9B2	6.87e-04	184	42	3	e33e2a887aafba7b6a31f00bb0dbe974b4359fd6
ToppCell	COVID-19-kidney-PCT-S1/S2\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1E CYP4F3 ABCC2	6.87e-04	184	42	3	dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCell	COVID-19-kidney-Mito-rich_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1E CYP4F3 ABCC2	6.98e-04	185	42	3	1bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCell	(7)_MNP-(7)_DC_plasmacytoid\|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)	TMEM109 OPN3 CADM4	6.98e-04	185	42	3	9f67f652488e17075a372e2a2e1100f6d0af6d7d
ToppCell	critical-Myeloid-pDC\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TOR3A DDOST MFSD3	6.98e-04	185	42	3	4a5d1d0a757f1f4fdb911be96ed90b52182c25f0
ToppCell	PBMC-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CERS6 OPN3 CADM4	7.09e-04	186	42	3	b70cd94c651b56dcf2e55554533a5f1130845390
ToppCell	PBMC-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CERS6 OPN3 CADM4	7.09e-04	186	42	3	31df1eafa3010bc1be6fc4d4689f1393d69b6b13
ToppCell	PBMC-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CERS6 OPN3 CADM4	7.09e-04	186	42	3	eaa431ccd4cdd36fe06a44987603ec9979025aa8
ToppCell	COVID-19_Severe-Myeloid-pDC\|COVID-19_Severe / Disease group, lineage and cell class	CERS6 OPN3 CADM4	7.09e-04	186	42	3	3db5ed69d49e5d79f990aca0295ddce4c297a05c
ToppCell	PBMC-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CERS6 OPN3 CADM4	7.09e-04	186	42	3	b95be984e308d4f9061274a35995ec558d434e74
ToppCell	PBMC-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CERS6 OPN3 CADM4	7.09e-04	186	42	3	8f7949740286f64e034d1eb533ebc2c6f71ae966
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E CYP4F3 ABCC2	7.09e-04	186	42	3	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	PBMC-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CERS6 OPN3 CADM4	7.09e-04	186	42	3	95c7318e521fb6aa02e244b1e81e6b2a62107756
ToppCell	3'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC5A9 CYP4F2 ABCC2	7.20e-04	187	42	3	9042bd0f57213a51503d9df2e4dce3209b7772d3
ToppCell	390C-Myeloid-Dendritic-cDC_activated\|390C / Donor, Lineage, Cell class and subclass (all cells)	CERS6 NPFFR1 OPN3	7.20e-04	187	42	3	60c2576f31a60f819deb9ec500d1f714b469df4e
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_granulocytic\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CYP4F3 AQP8 FREM1	7.31e-04	188	42	3	36ff615154d6d9e3ba6ccb73a0f11574bcbf5ece
ToppCell	COVID-19_Severe-pDC\|World / disease group, cell group and cell class	CERS6 OPN3 CADM4	7.31e-04	188	42	3	4c8e328b8206120708b05ea3c5865a0200dc5c4e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FADS3 TOR3A CHPT1	7.42e-04	189	42	3	b13f315f617840eb5143a4e8a33a657c20365c21
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	CERS6 OPN3 CADM4	7.54e-04	190	42	3	dde0e34f6a06cdbbb65c86472360c09f0279a572
ToppCell	metastatic_Lymph_Node-B_lymphocytes-MALT_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	MGAT1 TMEM208 DDOST	7.54e-04	190	42	3	5ec49cc7692053c1a525ca9137c996ccd2794e1c
ToppCell	COVID-19_Severe-pDC\|COVID-19_Severe / disease group, cell group and cell class	CERS6 OPN3 CADM4	7.54e-04	190	42	3	c5ab6b7492fb86aff3d2af3eb671c9f985ae4aeb
ToppCell	10x5'v1-week_14-16-Myeloid_DC-DC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TMEM109 OPN3 DDOST	7.54e-04	190	42	3	d06800ec9f6065c1cc536ed99e8569732272a94f
ToppCell	droplet-Heart-nan-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANTXR1 ISLR CHPT1	7.54e-04	190	42	3	96a92212ea3fb35fa3d0da495e504edc61c71c23
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-Plasma_cell-B_c05-MZB1-XBP1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GPAA1 TMEM208 DDOST	7.54e-04	190	42	3	f85cdd79eefd699ada7a91bf4997cc730a9b9846
ToppCell	10x5'v1-week_14-16-Myeloid_DC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TMEM109 OPN3 DDOST	7.54e-04	190	42	3	485073e831afebdb393c7f4b622504d43d1b778b
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CERS6 ISLR FREM1	7.65e-04	191	42	3	a05e9a7eb137d804570dd7d8905975d735738767
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic-B_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FADS3 CHPT1 SLC2A6	7.65e-04	191	42	3	31169e01072e5fea364178264a35754b6cf2c93b
ToppCell	Smart-seq2-spleen_(Smart-seq2)-lymphocytic-B_lymphocytic-plasma_cell\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TOR3A TMEM208 DDOST	7.65e-04	191	42	3	7b4b5d90d1023d03239ed986f273afa734d3124d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-Plasma_cell\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GPAA1 TMEM208 DDOST	7.77e-04	192	42	3	ec279980602292fc8ed6362edd36a5c772d59777
ToppCell	(1)_Control_(PBS)-(3)_LEPR+_perivascular_cells\|(1)_Control_(PBS) / Stress and Cell class	ANTXR1 ISLR FADS3	7.77e-04	192	42	3	40f380f5f0bed63a7404be050838ebd01ef08987
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ISLR CHPT1 FREM1	7.77e-04	192	42	3	de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCell	10x5'-GI_large-bowel-Lymphocytic_B-Memory_B_cells\|GI_large-bowel / Manually curated celltypes from each tissue	FADS3 CHPT1 GUCY2C	7.77e-04	192	42	3	31f7245bce79969674a775ecf175e7c6af68b503
ToppCell	PND14-Mesenchymal-Mesenchymal_structural\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ISLR CHPT1 FREM1	7.77e-04	192	42	3	25492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANTXR1 ISLR FREM1	7.89e-04	193	42	3	03678162648bd5b1d65a5450b60c8863edbf95c7
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANTXR1 ISLR FREM1	7.89e-04	193	42	3	59b8186d0221fba06a16157e9d148399ed801f38
ToppCell	COVID-19_Severe-Plasmablast\|COVID-19_Severe / disease group, cell group and cell class	TOR3A TMEM208 DDOST	7.89e-04	193	42	3	8074bcede261b85f9ae03ee372bd6d4b40384537
Disease	retinal disease (implicated_via_orthology)	OPN4 CHPT1	2.68e-05	6	40	2	DOID:5679 (implicated_via_orthology)
Disease	eicosapentaenoic acid measurement	FADS3 MUC22	8.13e-04	31	40	2	EFO_0007760
Disease	metabolite measurement	SLC5A9 CYP4F2 CERS6 ABCC2 GPAA1	9.20e-04	560	40	5	EFO_0004725
Disease	Colorectal Carcinoma	GRIN2A ISLR ABCC2 NODAL GUCY2C	2.48e-03	702	40	5	C0009402
Disease	ecosanoids measurement	CYP4F2 ABCC2	2.54e-03	55	40	2	EFO_0020044

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLLLALALLWWFWPL	ANTXR1	331	Q9H6X2
LVWERQLGLPLYLWA	CTC1	456	Q2NKJ3
ALGATWNWLYFIPLI	CACNA1E	321	Q15878
FHWIYWLGPLLAGLL	AQP8	226	O94778
PYASWWLLNGLLLTL	CERS5	306	Q8N5B7
LDLALWSLLFQPGWL	GUCY2C	6	P25092
LLVWLLLIFHGPNFW	NOX5	406	Q96PH1
LSWLPLWALLLLIDY	NPFFR1	281	Q9GZQ6
PLLSLGLYPCWLLFW	GPAA1	601	O43292
LWGAILFVAWNALLL	MGAT1	11	P26572
WFLWLLLFGLLGPSS	MUC22	11	E2RYF6
LLWWALLLGLAQACP	ISLR	6	O14498
WGAANAVLLLLLLAW	FREM1	6	Q5H8C1
VLVWIPLGYLWLLAP	ABCC2	31	Q92887
PLGYLWLLAPWQLLH	ABCC2	36	Q92887
WLGLAWLLLARAPDA	FGF22	6	Q9HCT0
LWLLLAYWKAGSGQL	PCDHA5	16	Q9Y5H7
AWALFWLLLPLLGAV	DDOST	26	P39656
SLSLYALGLLLPWRW	SLC2A6	181	Q9UGQ3
LYAPWLLKLAWAPLV	MFSD3	46	Q96ES6
TFPLYLLNFLGLWSW	METTL7A	16	Q9H8H3
RALLLWLAWLGLQAA	TM7SF2	61	O76062
WLAWLGLQAALYLLP	TM7SF2	66	O76062
LLGVWLYALAWSLPP	OPN4	191	Q9UHM6
IWLYSLAWAGAPLLG	OPN3	161	Q9H1Y3
RFQWPLLLLWAAAAG	CADM4	6	Q8NFZ8
GPYPSWWVFNLLLLL	CERS6	296	Q6ZMG9
ASPWLLLLLVGASWL	CYP4F2	16	P78329
ASPWLLLLLVGASWL	CYP4F3	16	Q08477
EVLAWLLIYLLGPGW	FADS3	146	Q9Y5Q0
LLLAWPLEGLAGNLW	MIEF2	316	Q96C03
LLTVAAGWLFYRPLW	TMEM43	361	Q9BTV4
AGWLFYRPLWALLIA	TMEM43	366	Q9BTV4
LPFLLHAWWALLQAG	NODAL	6	Q96S42
LLAHYLLGLPWQWGF	SLC9B2	221	Q86UD5
WLLLALGWVFVPVYI	SLC5A9	116	Q2M3M2
LLEPPLQLYWTWLLQ	CHPT1	41	Q8WUD6
WLWSPQIVGLYNRLL	PKP3	601	Q9Y446
LSRGWALWQALLALL	PKMYT1	376	Q99640
ALLLPAGPEFLWLWF	SLC27A3	171	Q5K4L6
APIWLILNEAGLYWR	TTC17	616	Q96AE7
WLLAPGRALYLLWVN	TMEM208	126	Q9BTX3
GRALYLLWVNVLGPW	TMEM208	131	Q9BTX3
FLLWGAGALVVYWLL	TMEM109	131	Q9BVC6
HPNGWYIWILLLLVL	TMEM207	46	Q6UWW9
WRQLWLFFLLLLPGA	TOR3A	6	Q9H497
YWTLLVLPALLVWRG	GRIN2A	6	Q12879