Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbeta-adrenergic receptor activity

ADRB1 ADRB2 ADRB3

2.29e-074783GO:0004939
GeneOntologyMolecularFunctionhistone deacetylase activity

HDAC9 HDAC5 HDAC4 HDAC7

2.16e-0624784GO:0004407
GeneOntologyMolecularFunctionprotein lysine deacetylase activity

HDAC9 HDAC5 HDAC4 HDAC7

2.56e-0625784GO:0033558
GeneOntologyMolecularFunctionATP-dependent activity

PMS1 MRE11 MYO6 IGHMBP2 HELZ2 HLTF MACF1 NLRP1 DHX32 ATP2A1 ATP2A2 ATP2A3

4.37e-066147812GO:0140657
GeneOntologyMolecularFunctionadrenergic receptor activity

ADRB1 ADRB2 ADRB3

6.75e-0610783GO:0004935
GeneOntologyMolecularFunctionP-type calcium transporter activity

ATP2A1 ATP2A2 ATP2A3

9.25e-0611783GO:0005388
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

HDAC9 HDAC5 HDAC4 ASAH1 HDAC7

1.62e-0581785GO:0016811
GeneOntologyMolecularFunctiondeacetylase activity

HDAC9 HDAC5 HDAC4 HDAC7

1.77e-0540784GO:0019213
GeneOntologyMolecularFunctionATP hydrolysis activity

PMS1 IGHMBP2 HELZ2 MACF1 NLRP1 DHX32 ATP2A1 ATP2A2 ATP2A3

5.46e-05441789GO:0016887
GeneOntologyMolecularFunctionnorepinephrine binding

ADRB2 ADRB3

8.99e-054782GO:0051380
GeneOntologyMolecularFunctioncalcium-dependent ATPase activity

ATP2A1 ATP2A3

8.99e-054782GO:0030899
GeneOntologyMolecularFunctioncysteine-type endopeptidase activator activity involved in apoptotic process

NLRP12 NLRP1 ATP2A3

1.95e-0429783GO:0008656
GeneOntologyMolecularFunctionpeptidase activator activity involved in apoptotic process

NLRP12 NLRP1 ATP2A3

2.62e-0432783GO:0016505
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

HDAC9 HDAC5 HDAC4 ASAH1 HDAC7

2.68e-04146785GO:0016810
GeneOntologyMolecularFunctiontranscription corepressor activity

HDAC9 HDAC5 HDAC4 ASAH1 HDAC7 TDP2

2.75e-04229786GO:0003714
GeneOntologyMolecularFunctionP-type transmembrane transporter activity

ATP2A1 ATP2A2 ATP2A3

3.73e-0436783GO:0140358
GeneOntologyMolecularFunctionP-type ion transporter activity

ATP2A1 ATP2A2 ATP2A3

3.73e-0436783GO:0015662
GeneOntologyMolecularFunctionhelicase activity

MRE11 IGHMBP2 HELZ2 HLTF DHX32

3.86e-04158785GO:0004386
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

PMS1 IGHMBP2 HELZ2 HLTF MACF1 NLRP1 DHX32 RHOT2 ATP2A1 ATP2A2 ATP2A3

4.05e-048407811GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

PMS1 IGHMBP2 HELZ2 HLTF MACF1 NLRP1 DHX32 RHOT2 ATP2A1 ATP2A2 ATP2A3

4.05e-048407811GO:0016818
GeneOntologyMolecularFunctionG protein-coupled amine receptor activity

ADRB1 ADRB2 ADRB3

5.49e-0441783GO:0008227
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

PMS1 MRE11 IGHMBP2 HLTF TOP3B TDP2

5.62e-04262786GO:0140097
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

PMS1 IGHMBP2 HELZ2 MACF1 NLRP1 DHX32 RHOT2 ATP2A1 ATP2A2 ATP2A3

8.48e-047757810GO:0017111
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

PMS1 MRE11 NSUN5 IGHMBP2 HELZ2 HLTF DHX32 TOP3B TDP2

9.06e-04645789GO:0140640
GeneOntologyMolecularFunctioncatecholamine binding

ADRB2 ADRB3

1.14e-0313782GO:1901338
GeneOntologyMolecularFunctioncysteine-type endopeptidase regulator activity involved in apoptotic process

NLRP12 NLRP1 ATP2A3

1.23e-0354783GO:0043028
GeneOntologyMolecularFunctionpyrophosphatase activity

PMS1 IGHMBP2 HELZ2 MACF1 NLRP1 DHX32 RHOT2 ATP2A1 ATP2A2 ATP2A3

1.54e-038397810GO:0016462
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

PMS1 MRE11 IGHMBP2 HLTF

1.55e-03127784GO:0008094
GeneOntologyMolecularFunctionATPase-coupled monoatomic cation transmembrane transporter activity

ATP2A1 ATP2A2 ATP2A3

1.84e-0362783GO:0019829
GeneOntologyMolecularFunctionprotein kinase C binding

HDAC9 HDAC5 HDAC7

2.20e-0366783GO:0005080
GeneOntologyMolecularFunctionpeptidase activator activity

NLRP12 NLRP1 ATP2A3

2.60e-0370783GO:0016504
GeneOntologyMolecularFunctionRNA helicase activity

IGHMBP2 HELZ2 DHX32

3.53e-0378783GO:0003724
GeneOntologyMolecularFunctionATP-dependent activity, acting on RNA

IGHMBP2 HELZ2 DHX32

3.80e-0380783GO:0008186
GeneOntologyMolecularFunctionadrenergic receptor binding

ADRB1 ADRB3

3.93e-0324782GO:0031690
GeneOntologyBiologicalProcessnorepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

ADRB1 ADRB2 ADRB3

5.00e-083773GO:0002025
GeneOntologyBiologicalProcessregulation of skeletal muscle fiber differentiation

HDAC9 HDAC5 HDAC4

1.73e-067773GO:1902809
GeneOntologyBiologicalProcessadenylate cyclase-activating adrenergic receptor signaling pathway

ADRB1 ADRB2 ADRB3 ADCY9

2.14e-0625774GO:0071880
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure by norepinephrine-epinephrine

ADRB1 ADRB2 ADRB3

2.76e-068773GO:0001993
GeneOntologyBiologicalProcessbrown fat cell differentiation

FBN1 ADRB1 ADRB2 ADRB3 SH2B2

5.12e-0667775GO:0050873
GeneOntologyBiologicalProcessadrenergic receptor signaling pathway

ADRB1 ADRB2 ADRB3 ADCY9

8.61e-0635774GO:0071875
GeneOntologyBiologicalProcessregulation of muscle cell differentiation

HDAC9 ADRB1 HDAC5 HDAC4 SUPT6H TNPO2 PPARA

9.51e-06199777GO:0051147
GeneOntologyBiologicalProcessnegative regulation of striated muscle tissue development

HDAC9 HDAC5 HDAC7

1.07e-0512773GO:0045843
GeneOntologyBiologicalProcesscalcium ion transport from cytosol to endoplasmic reticulum

ATP2A2 ATP2A3

1.38e-052772GO:1903515
GeneOntologyBiologicalProcessnegative regulation of muscle organ development

HDAC9 HDAC5 HDAC7

1.77e-0514773GO:0048635
GeneOntologyBiologicalProcessregulation of skeletal muscle fiber development

HDAC9 HDAC5 HDAC4

1.77e-0514773GO:0048742
GeneOntologyBiologicalProcessskeletal muscle fiber differentiation

HDAC9 HDAC5 HDAC4

2.71e-0516773GO:0098528
GeneOntologyBiologicalProcessdiet induced thermogenesis

ADRB1 ADRB2 ADRB3

3.28e-0517773GO:0002024
GeneOntologyBiologicalProcessnegative regulation of multicellular organism growth

ADRB1 ADRB2 ADRB3

3.28e-0517773GO:0040015
GeneOntologyBiologicalProcessnegative regulation of muscle tissue development

HDAC9 HDAC5 HDAC7

3.92e-0518773GO:1901862
GeneOntologyBiologicalProcesspositive regulation of endoplasmic reticulum calcium ion concentration

ATP2A1 ATP2A2

4.12e-053772GO:0032470
GeneOntologyBiologicalProcessregulation of striated muscle contraction

ADRB1 HDAC4 KBTBD13 ATP2A1 ATP2A2

5.98e-05111775GO:0006942
GeneOntologyBiologicalProcessregulation of muscle tissue development

HDAC9 ADRB2 HDAC5 HDAC7

6.10e-0557774GO:1901861
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure mediated by a chemical signal

ADRB1 ADRB2 ADRB3 SLC2A5

7.97e-0561774GO:0003044
GeneOntologyBiologicalProcessrelaxation of skeletal muscle

KBTBD13 ATP2A1

8.21e-054772GO:0090076
GeneOntologyBiologicalProcesspositive regulation of the force of heart contraction by epinephrine-norepinephrine

ADRB1 ADRB2

8.21e-054772GO:0001997
GeneOntologyBiologicalProcessheat generation

ADRB1 ADRB2 ADRB3

8.40e-0523773GO:0031649
GeneOntologyBiologicalProcessregulation of striated muscle cell differentiation

HDAC9 ADRB1 HDAC5 HDAC4 PPARA

9.74e-05123775GO:0051153
GeneOntologyBiologicalProcessregulation of striated muscle tissue development

HDAC9 HDAC5 HDAC7

1.08e-0425773GO:0016202
GeneOntologyBiologicalProcessregulation of muscle contraction

ADRB1 ADRB2 HDAC4 KBTBD13 ATP2A1 ATP2A2

1.09e-04202776GO:0006937
GeneOntologyBiologicalProcessnegative regulation of blood pressure

ADRB1 ADRB2 ADRB3 PPARA

1.37e-0470774GO:0045776
GeneOntologyBiologicalProcesscellular response to fructose stimulus

PPARA SLC2A5

1.37e-045772GO:0071332
GeneOntologyBiologicalProcesspositive regulation of the force of heart contraction by chemical signal

ADRB1 ADRB2

1.37e-045772GO:0003099
GeneOntologyBiologicalProcesscytosol to endoplasmic reticulum transport

ATP2A2 ATP2A3

1.37e-045772GO:0046967
GeneOntologyBiologicalProcessDNA repair

PMS1 HDAC9 MRE11 RIF1 PARP4 HLTF NHEJ1 FAAP100 TOP3B TDP2

1.44e-046487710GO:0006281
GeneOntologyBiologicalProcessregulation of skeletal muscle cell differentiation

HDAC9 HDAC5 HDAC4

1.53e-0428773GO:2001014
GeneOntologyBiologicalProcessresponse to peptide hormone

ECHDC3 HDAC9 FBN1 HDAC5 PPARA ATP2A1 ATP2A2 SH2B2 C2CD5

1.56e-04530779GO:0043434
GeneOntologyBiologicalProcessstriated muscle contraction

ADRB1 ADRB2 HDAC4 KBTBD13 ATP2A1 ATP2A2

1.61e-04217776GO:0006941
GeneOntologyBiologicalProcessendoplasmic reticulum calcium ion homeostasis

ATP2A1 ATP2A2 ATP2A3

1.70e-0429773GO:0032469
GeneOntologyBiologicalProcessregulation of cardiac conduction

ATP2A1 ATP2A2 ATP2A3

1.70e-0429773GO:1903779
GeneOntologyBiologicalProcessregulation of muscle system process

ADRB1 ADRB2 HDAC4 KBTBD13 PPARA ATP2A1 ATP2A2

1.82e-04317777GO:0090257
GeneOntologyBiologicalProcesspeptidyl-lysine deacetylation

HDAC9 HDAC4

2.04e-046772GO:0034983
GeneOntologyBiologicalProcessregulation of muscle organ development

HDAC9 HDAC5 HDAC7

2.09e-0431773GO:0048634
GeneOntologyBiologicalProcessnegative regulation of systemic arterial blood pressure

ADRB1 ADRB2 ADRB3

2.30e-0432773GO:0003085
GeneOntologyBiologicalProcessregulation of the force of heart contraction

ADRB1 ADRB2 ATP2A2

2.52e-0433773GO:0002026
GeneOntologyBiologicalProcessnegative regulation of muscle cell differentiation

HDAC5 HDAC4 TNPO2 PPARA

2.64e-0483774GO:0051148
GeneOntologyBiologicalProcessB cell activation

HDAC9 RIF1 HDAC5 HDAC4 SUPT6H NHEJ1 HDAC7

2.83e-04341777GO:0042113
GeneOntologyBiologicalProcesspositive regulation of blood pressure by epinephrine-norepinephrine

ADRB1 ADRB2

2.85e-047772GO:0003321
GeneOntologyBiologicalProcesscalcium ion import into sarcoplasmic reticulum

ATP2A1 ATP2A2

2.85e-047772GO:1990036
GeneOntologyBiologicalProcessnegative regulation of muscle contraction

ADRB1 ADRB2 ATP2A1

3.00e-0435773GO:0045932
GeneOntologyBiologicalProcessregulation of heart contraction

ADRB1 ADRB2 HDAC4 ATP2A1 ATP2A2 ATP2A3

3.38e-04249776GO:0008016
GeneOntologyBiologicalProcessregulation of cardiac muscle contraction

ADRB1 HDAC4 ATP2A1 ATP2A2

3.45e-0489774GO:0055117
GeneOntologyBiologicalProcessregulation of the force of heart contraction by chemical signal

ADRB1 ADRB2

3.80e-048772GO:0003057
GeneOntologyBiologicalProcessmuscle cell development

HDAC9 ADRB1 HDAC5 HDAC4 PPARA ATP2A2

4.16e-04259776GO:0055001
GeneOntologyBiologicalProcessinflammatory response

HDAC9 NLRP12 PARP4 FASN NLRP9 HDAC5 HDAC4 NLRP1 PPARA NLRP4 HDAC7 PXK

4.61e-0410437712GO:0006954
GeneOntologyBiologicalProcessrelaxation of muscle

KBTBD13 ATP2A1 ATP2A2

5.17e-0442773GO:0090075
GeneOntologyBiologicalProcessregulation of cardiac muscle cell contraction

ADRB1 ATP2A1 ATP2A2

5.54e-0443773GO:0086004
GeneOntologyBiologicalProcessresponse to fructose

PPARA SLC2A5

6.07e-0410772GO:0009750
GeneOntologyBiologicalProcessblood circulation

ADRB1 ADRB2 ADRB3 HDAC4 PPARA ATP2A1 ATP2A2 ATP2A3 SLC2A5

6.78e-04648779GO:0008015
GeneOntologyBiologicalProcessresponse to dietary excess

ADRB1 ADRB2 ADRB3

7.21e-0447773GO:0002021
GeneOntologyBiologicalProcessprotein deacetylation

HDAC9 HDAC4 HDAC7

7.21e-0447773GO:0006476
GeneOntologyBiologicalProcessnegative regulation of urine volume

ADRB1 ADRB2

7.40e-0411772GO:0035811
GeneOntologyBiologicalProcessadenylate cyclase-activating G protein-coupled receptor signaling pathway

ADRB1 ADRB2 ADRB3 ADCY9 ADGRG6

7.44e-04191775GO:0007189
GeneOntologyBiologicalProcessmuscle cell differentiation

HDAC9 ADRB1 HDAC5 HDAC4 SUPT6H TNPO2 PPARA ATP2A2

8.11e-04531778GO:0042692
GeneOntologyBiologicalProcesspositive regulation of heart contraction

ADRB1 ADRB2 ATP2A2

8.15e-0449773GO:0045823
GeneOntologyBiologicalProcessskeletal muscle fiber development

HDAC9 HDAC5 HDAC4

8.15e-0449773GO:0048741
GeneOntologyBiologicalProcessDNA damage response

PMS1 HDAC9 MRE11 RIF1 PARP4 MYO6 HLTF NHEJ1 FAAP100 TOP3B TDP2

8.33e-049597711GO:0006974
GeneOntologyBiologicalProcessheart contraction

ADRB1 ADRB2 HDAC4 ATP2A1 ATP2A2 ATP2A3

8.68e-04298776GO:0060047
GeneOntologyBiologicalProcessnegative regulation of striated muscle cell differentiation

HDAC5 HDAC4 PPARA

9.16e-0451773GO:0051154
GeneOntologyBiologicalProcessB cell differentiation

HDAC9 HDAC5 HDAC4 NHEJ1 HDAC7

9.36e-04201775GO:0030183
GeneOntologyBiologicalProcessresponse to cold

ADRB1 ADRB2 ADRB3

9.69e-0452773GO:0009409
GeneOntologyBiologicalProcessskeletal muscle contraction

ADRB2 KBTBD13 ATP2A1

9.69e-0452773GO:0003009
GeneOntologyBiologicalProcesspositive regulation of blood circulation

ADRB1 ADRB2 ATP2A2

1.02e-0353773GO:1903524
GeneOntologyBiologicalProcessregulation of actin filament-based movement

ADRB1 ATP2A1 ATP2A2

1.02e-0353773GO:1903115
GeneOntologyBiologicalProcesspositive regulation of calcium ion import across plasma membrane

ADRB1 ADRB2

1.04e-0313772GO:1905665
GeneOntologyBiologicalProcessheart process

ADRB1 ADRB2 HDAC4 ATP2A1 ATP2A2 ATP2A3

1.05e-03309776GO:0003015
GeneOntologyBiologicalProcessmyotube cell development

HDAC9 HDAC5 HDAC4

1.08e-0354773GO:0014904
GeneOntologyBiologicalProcessregulation of myotube differentiation

HDAC9 HDAC5 HDAC4

1.14e-0355773GO:0010830
GeneOntologyBiologicalProcessintracellular transport

SNX30 TRAPPC11 ADRB2 MYO6 SUPT6H TNPO2 LMTK2 RHOT2 AP4B1 ATP2A1 ATP2A2 ATP2A3 PXK C2CD5

1.17e-0314967714GO:0046907
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure

ADRB1 ADRB2 ADRB3 SLC2A5

1.20e-03124774GO:0003073
GeneOntologyBiologicalProcessnegative regulation of receptor binding

ATP2A2 ATP2A3

1.22e-0314772GO:1900121
GeneOntologyBiologicalProcessnegative regulation of developmental growth

ADRB1 ADRB2 ADRB3 PPARA

1.27e-03126774GO:0048640
GeneOntologyBiologicalProcessmuscle structure development

HDAC9 ADRB1 ADRB2 HDAC5 HDAC4 SUPT6H TNPO2 PPARA ATP2A2 HDAC7

1.29e-038587710GO:0061061
GeneOntologyBiologicalProcessprotein deacylation

HDAC9 HDAC4 HDAC7

1.33e-0358773GO:0035601
GeneOntologyBiologicalProcessregulation of blood circulation

ADRB1 ADRB2 HDAC4 ATP2A1 ATP2A2 ATP2A3

1.38e-03326776GO:1903522
GeneOntologyBiologicalProcessregulation of interleukin-18 production

NLRP12 NLRP9

1.40e-0315772GO:0032661
GeneOntologyBiologicalProcessregulation of muscle adaptation

ADRB1 HDAC4 PPARA ATP2A2

1.55e-03133774GO:0043502
GeneOntologyBiologicalProcesscirculatory system process

ADRB1 ADRB2 ADRB3 HDAC4 PPARA ATP2A1 ATP2A2 ATP2A3 SLC2A5

1.60e-03733779GO:0003013
GeneOntologyBiologicalProcessregulation of protein binding

HDAC5 HDAC4 UBASH3B ATP2A2 ATP2A3

1.64e-03228775GO:0043393
GeneOntologyBiologicalProcessmacromolecule deacylation

HDAC9 HDAC4 HDAC7

1.69e-0363773GO:0098732
GeneOntologyBiologicalProcessresponse to insulin

ECHDC3 HDAC9 HDAC5 PPARA SH2B2 C2CD5

1.75e-03342776GO:0032868
GeneOntologyBiologicalProcessnegative regulation of developmental process

HDAC9 FBN1 ADRB1 ADRB2 ADRB3 HDAC5 HDAC4 TP53INP1 TNPO2 PPARA UBASH3B HDAC7

1.80e-0312207712GO:0051093
GeneOntologyBiologicalProcessinterleukin-18 production

NLRP12 NLRP9

1.80e-0317772GO:0032621
GeneOntologyBiologicalProcessregulation of blood pressure

ADRB1 ADRB2 ADRB3 PPARA SLC2A5

1.94e-03237775GO:0008217
GeneOntologyBiologicalProcesscardiac muscle hypertrophy

ADRB1 HDAC4 PPARA ATP2A2

1.97e-03142774GO:0003300
GeneOntologyBiologicalProcessDNA metabolic process

PMS1 HDAC9 MRE11 RIF1 PARP4 SUPT6H HLTF NHEJ1 FAAP100 TOP3B TDP2

2.17e-0310817711GO:0006259
GeneOntologyBiologicalProcessstriated muscle hypertrophy

ADRB1 HDAC4 PPARA ATP2A2

2.18e-03146774GO:0014897
GeneOntologyBiologicalProcesssomatic recombination of immunoglobulin gene segments

RIF1 SUPT6H NHEJ1

2.20e-0369773GO:0016447
GeneOntologyBiologicalProcessmusculoskeletal movement

ADRB2 KBTBD13 ATP2A1

2.20e-0369773GO:0050881
GeneOntologyBiologicalProcessregulation of calcium ion import across plasma membrane

ADRB1 ADRB2

2.26e-0319772GO:1905664
GeneOntologyBiologicalProcessosteoblast development

HDAC5 HDAC4

2.26e-0319772GO:0002076
GeneOntologyBiologicalProcessmuscle hypertrophy

ADRB1 HDAC4 PPARA ATP2A2

2.30e-03148774GO:0014896
GeneOntologyCellularComponentplatelet dense tubular network membrane

ATP2A1 ATP2A2 ATP2A3

4.13e-069783GO:0031095
GeneOntologyCellularComponentplatelet dense tubular network

ATP2A1 ATP2A2 ATP2A3

8.07e-0611783GO:0031094
GeneOntologyCellularComponenthistone deacetylase complex

HDAC9 HDAC5 HDAC4 HDAC7

2.89e-0485784GO:0000118
GeneOntologyCellularComponentsarcoplasmic reticulum

MTMR12 ATP2A1 ATP2A2 ATP2A3

3.30e-0488784GO:0016529
GeneOntologyCellularComponentsarcoplasmic reticulum membrane

ATP2A1 ATP2A2 ATP2A3

6.33e-0445783GO:0033017
GeneOntologyCellularComponentsarcoplasm

MTMR12 ATP2A1 ATP2A2 ATP2A3

8.77e-04114784GO:0016528
GeneOntologyCellularComponentendosome

ZFYVE28 SNX30 ADRB1 ADRB2 MYO6 ASAH1 OSBPL1A LMTK2 SLC26A9 AP4B1 THSD1 PXK

1.24e-0311677812GO:0005768
DomainHistone_deAcase_II_euk

HDAC9 HDAC5 HDAC4 HDAC7

2.81e-104784IPR017320
DomainHist_deacetylase_Gln_rich_N

HDAC9 HDAC5 HDAC4

7.01e-083783IPR024643
DomainHDAC4_Gln

HDAC9 HDAC5 HDAC4

7.01e-083783PF12203
DomainP-type_ATPase_IIA

ATP2A1 ATP2A2 ATP2A3

7.01e-083783IPR005782
DomainHist_deacetyl

HDAC9 HDAC5 HDAC4 HDAC7

9.08e-0811784PF00850
DomainHis_deacetylse_dom

HDAC9 HDAC5 HDAC4 HDAC7

9.08e-0811784IPR023801
Domain-

HDAC9 HDAC5 HDAC4 HDAC7

9.08e-08117843.40.800.20
DomainHis_deacetylse

HDAC9 HDAC5 HDAC4 HDAC7

9.08e-0811784IPR000286
DomainDAPIN

NLRP12 NLRP9 NLRP1 NLRP4

1.94e-0622784PS50824
DomainPYRIN

NLRP12 NLRP9 NLRP1 NLRP4

1.94e-0622784PF02758
DomainDAPIN

NLRP12 NLRP9 NLRP1 NLRP4

1.94e-0622784IPR004020
DomainPYRIN

NLRP12 NLRP9 NLRP1 NLRP4

1.94e-0622784SM01289
DomainNACHT

NLRP12 NLRP9 NLRP1 NLRP4

2.35e-0623784PS50837
DomainNACHT_NTPase

NLRP12 NLRP9 NLRP1 NLRP4

2.35e-0623784IPR007111
DomainHydrolase_3

ATP2A1 ATP2A2 ATP2A3

8.23e-0610783PF08282
DomainADR_fam

ADRB1 ADRB2 ADRB3

8.23e-0610783IPR002233
Domain-

ATP2A1 ATP2A2 ATP2A3

3.77e-05167831.20.1110.10
DomainATPase_P-typ_TM_dom

ATP2A1 ATP2A2 ATP2A3

3.77e-0516783IPR023298
DomainATPase_P-typ_cation-transptr_C

ATP2A1 ATP2A2 ATP2A3

4.57e-0517783IPR006068
DomainCation_ATPase_C

ATP2A1 ATP2A2 ATP2A3

4.57e-0517783PF00689
DomainCation_ATPase_N

ATP2A1 ATP2A2 ATP2A3

5.47e-0518783PF00690
DomainCation_ATPase_N

ATP2A1 ATP2A2 ATP2A3

5.47e-0518783SM00831
DomainATPase_P-typ_cation-transptr_N

ATP2A1 ATP2A2 ATP2A3

6.47e-0519783IPR004014
DomainLRR_6

NLRP12 NLRP9 NLRP1 NLRP4

8.17e-0555784PF13516
Domain-

ATP2A1 ATP2A2 ATP2A3

3.19e-04327833.40.1110.10
Domain-

ATP2A1 ATP2A2 ATP2A3

3.19e-04327832.70.150.10
DomainATPase_P-typ_cyto_domN

ATP2A1 ATP2A2 ATP2A3

4.17e-0435783IPR023299
DomainP_typ_ATPase

ATP2A1 ATP2A2 ATP2A3

4.53e-0436783IPR001757
DomainATPase_P-typ_P_site

ATP2A1 ATP2A2 ATP2A3

4.53e-0436783IPR018303
DomainATPASE_E1_E2

ATP2A1 ATP2A2 ATP2A3

4.53e-0436783PS00154
DomainATPase_P-typ_transduc_dom_A

ATP2A1 ATP2A2 ATP2A3

4.92e-0437783IPR008250
DomainE1-E2_ATPase

ATP2A1 ATP2A2 ATP2A3

4.92e-0437783PF00122
Domain-

NLRP12 NLRP9 NLRP1 NLRP4

6.20e-04937841.10.533.10
DomainDEATH-like_dom

NLRP12 NLRP9 NLRP1 NLRP4

7.85e-0499784IPR011029
DomainP-loop_NTPase

NLRP12 NLRP9 MYO6 IGHMBP2 HELZ2 HLTF NLRP1 DHX32 RHOT2 NLRP4

2.71e-038487810IPR027417
DomainARM-type_fold

ARFGEF3 RIF1 PELP1 TNPO2 AP4B1 VIRMA

2.93e-03339786IPR016024
Domain-

NLRP12 NLRP9 IGHMBP2 HELZ2 HLTF NLRP1 DHX32 RHOT2 NLRP4

3.83e-037467893.40.50.300
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_SERCA

ATP2A1 ATP2A2 ATP2A3

3.65e-068583M47955
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

HDAC9 HDAC5 HDAC4 HDAC7

4.91e-0628584M6177
PathwayREACTOME_ADRENOCEPTORS

ADRB1 ADRB2 ADRB3

5.46e-069583M27302
PathwayREACTOME_ADRENOCEPTORS

ADRB1 ADRB2 ADRB3

5.46e-069583MM15009
PathwayWP_ETHANOL_EFFECTS_ON_HISTONE_MODIFICATIONS

HDAC9 HDAC5 HDAC4 HDAC7

7.47e-0631584M39714
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

ADRB1 ADRB2 ADRB3 ATP2A1 ATP2A2 ATP2A3 ADCY9

7.95e-06178587M2890
PathwayWP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR

HDAC9 HDAC5 HDAC4 HDAC7

8.51e-0632584M39521
PathwayPID_HDAC_CLASSII_PATHWAY

HDAC9 HDAC5 HDAC4 HDAC7

1.09e-0534584M30
PathwayREACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS

ATP2A1 ATP2A2 ATP2A3

1.42e-0512583M27326
PathwayREACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS

ATP2A1 ATP2A2 ATP2A3

2.33e-0514583MM15052
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

ADRB1 ADRB2 ADRB3 ATP2A2 ATP2A3 ADCY9

3.01e-05147586MM15854
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

ADRB1 ADRB2 ADRB3 ATP2A2 ATP2A3 ADCY9

3.50e-05151586M39329
PathwayWP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE

ADRB1 ADRB2 ADCY9

3.56e-0516583M39849
PathwayWP_ATM_SIGNALING_IN_DEVELOPMENT_AND_DISEASE

MRE11 RIF1 HDAC4 NHEJ1

4.03e-0547584M39518
PathwayREACTOME_NONHOMOLOGOUS_END_JOINING_NHEJ

MRE11 RIF1 NHEJ1 TDP2

4.03e-0547584MM15296
PathwayREACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

HDAC9 HDAC5 HDAC4 HDAC7

4.39e-0548584M611
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

ATP2A1 ATP2A2 ATP2A3

5.16e-0518583M614
PathwayREACTOME_SIGNALING_BY_NOTCH

HDAC9 HDAC5 HDAC4 ATP2A1 ATP2A2 ATP2A3 HDAC7

6.37e-05246587M10189
PathwayWP_CARDIAC_HYPERTROPHIC_RESPONSE

HDAC9 HDAC5 HDAC4 HDAC7

7.52e-0555584M39685
PathwayREACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER

HDAC9 HDAC5 HDAC4 HDAC7

9.27e-0558584M29616
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

HDAC5 HDAC4 HDAC7

1.10e-0423583MM14954
PathwayPID_HDAC_CLASSI_PATHWAY

HDAC9 HDAC5 HDAC4 HDAC7

1.54e-0466584M101
PathwayBIOCARTA_CARM_ER_PATHWAY

HDAC5 HDAC4 PELP1

1.61e-0426583M2499
PathwayREACTOME_NONHOMOLOGOUS_END_JOINING_NHEJ

MRE11 RIF1 NHEJ1 TDP2

1.73e-0468584M27587
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ATP2A1 ATP2A2 ATP2A3

1.80e-0427583MM15053
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ATP2A1 ATP2A2 ATP2A3

2.01e-0428583M924
PathwayREACTOME_SIGNALING_BY_NOTCH1

HDAC9 HDAC5 HDAC4 HDAC7

2.40e-0474584M616
PathwayWP_MONOAMINE_GPCRS

ADRB1 ADRB2 ADRB3

2.74e-0431583MM15871
PathwayWP_MONOAMINE_GPCRS

ADRB1 ADRB2 ADRB3

3.30e-0433583M39585
PathwayWP_NONHOMOLOGOUS_END_JOINING

MRE11 NHEJ1

3.45e-047582MM15989
PathwayWP_NUCLEOTIDEBINDING_OLIGOMERIZATION_DOMAIN_NOD_PATHWAY

NLRP12 NLRP1 NLRP4

6.31e-0441583M39698
PathwayWP_NEURAL_CREST_DIFFERENTIATION

HDAC9 HDAC5 HDAC4 HDAC7

6.72e-0497584MM15926
PathwayREACTOME_AMINE_LIGAND_BINDING_RECEPTORS

ADRB1 ADRB2 ADRB3

6.77e-0442583M5868
PathwayREACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP

FASN HELZ2 PPARA

6.77e-0442583M27172
PathwayREACTOME_AMINE_LIGAND_BINDING_RECEPTORS

ADRB1 ADRB2 ADRB3

6.77e-0442583MM14971
PathwayWP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY

HDAC9 HDAC5 HDAC4 HDAC7

7.26e-0499584MM15905
PathwayWP_NEURAL_CREST_DIFFERENTIATION

HDAC9 HDAC5 HDAC4 HDAC7

7.83e-04101584M39448
PathwayWP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY

HDAC9 HDAC5 HDAC4 HDAC7

8.74e-04104584M39625
PathwayBIOCARTA_RANBP2_PATHWAY

HDAC9 HDAC4

8.93e-0411582M22027
PathwayKEGG_NON_HOMOLOGOUS_END_JOINING

MRE11 NHEJ1

1.26e-0313582M7857
PathwayREACTOME_IRF3_MEDIATED_INDUCTION_OF_TYPE_I_IFN

MRE11 NLRP4

1.26e-0313582M27240
PathwayKEGG_MEDICUS_REFERENCE_NON_HOMOLOGOUS_END_JOINING

RIF1 NHEJ1

1.26e-0313582M47837
PathwayREACTOME_ION_HOMEOSTASIS

ATP2A1 ATP2A2 ATP2A3

1.41e-0354583M27460
PathwayREACTOME_ION_HOMEOSTASIS

ATP2A1 ATP2A2 ATP2A3

1.41e-0354583MM15202
PathwayBIOCARTA_PGC1A_PATHWAY

HDAC5 PPARA

1.47e-0314582MM1473
PathwayREACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF

FASN HELZ2 PPARA

1.49e-0355583M27001
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP2A1 ATP2A2 ATP2A3

1.49e-0355583M971
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP2A1 ATP2A2 ATP2A3

1.65e-0357583MM15643
PathwayKEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY

ADRB2 ADCY9

1.69e-0315582M47794
PathwayBIOCARTA_PGC1A_PATHWAY

HDAC5 PPARA

1.69e-0315582M15181
PathwayREACTOME_STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES

MRE11 NLRP4

1.92e-0316582M27045
PathwayWP_SREBF_AND_MIR33_IN_CHOLESTEROL_AND_LIPID_HOMEOSTASIS

FASN PPARA

2.44e-0318582M39679
PathwayBIOCARTA_RANBP2_PATHWAY

HDAC9 HDAC5

2.44e-0318582MM1549
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

HELZ2 PPARA

2.44e-0318582MM15034
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

HELZ2 PPARA

2.44e-0318582M26942
PathwayREACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR

MRE11 RIF1 NHEJ1 TDP2

3.04e-03146584MM15292
PathwayWP_ALZHEIMERS_DISEASE

ATP2A1 ATP2A2 ATP2A3

3.48e-0374583MM15962
PathwayWP_FATTY_ACID_BIOSYNTHESIS

ECHDC3 FASN

3.65e-0322582M39440
PathwayREACTOME_METABOLISM_OF_STEROIDS

FASN OSBPL1A HELZ2 PPARA

3.68e-03154584M27832
PathwayREACTOME_PLATELET_HOMEOSTASIS

ATP2A1 ATP2A2 ATP2A3

3.76e-0376583MM15051
PathwayWP_ESTROGEN_SIGNALING

HDAC5 HDAC4 HDAC7

3.90e-0377583MM15934
PathwayREACTOME_G_ALPHA_S_SIGNALLING_EVENTS

ADRB1 ADRB2 ADRB3 ADCY9

3.94e-03157584M4904
PathwayWP_FATTY_ACID_BIOSYNTHESIS

ECHDC3 FASN

3.98e-0323582MM15885
Pubmed

Class IIa histone deacetylases: conducting development and differentiation.

HDAC9 HDAC5 HDAC4 HDAC7

2.47e-11479419412888
Pubmed

Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1.

HDAC9 HDAC5 HDAC4 HDAC7

1.23e-10579415194749
Pubmed

Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers.

HDAC9 HDAC5 HDAC4 HDAC7

1.71e-09879417786239
Pubmed

Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo.

HDAC9 HDAC5 HDAC4 HDAC7

3.08e-09979411466315
Pubmed

Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development.

HDAC9 HDAC5 HDAC4 HDAC7

3.08e-09979415367668
Pubmed

The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment.

HDAC9 HDAC5 HDAC4 HDAC7

3.08e-09979416260608
Pubmed

Class II histone deacetylases: versatile regulators.

HDAC9 HDAC5 HDAC4 HDAC7

5.12e-091079412711221
Pubmed

Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina.

HDAC9 HDAC5 HDAC4 HDAC7

5.12e-091079428028172
Pubmed

MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration.

HDAC9 HDAC5 HDAC4 HDAC7

8.04e-091179431223056
Pubmed

[The genotype analysis of beta adrenergic receptor gene family in high risk population of hypertension in northeast China].

ADRB1 ADRB2 ADRB3

1.13e-08379315079793
Pubmed

Mice lacking beta-adrenergic receptors have increased bone mass but are not protected from deleterious skeletal effects of ovariectomy.

ADRB1 ADRB2 ADRB3

1.13e-08379318801900
Pubmed

Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice.

ADRB1 ADRB2 ADRB3

1.13e-08379328752049
Pubmed

Differential expression and role of hyperglycemia induced oxidative stress in epigenetic regulation of β1, β2 and β3-adrenergic receptors in retinal endothelial cells.

ADRB1 ADRB2 ADRB3

1.13e-08379324885710
Pubmed

[The relationship between expressions of beta1-, beta2-, beta3-adrenoceptor mRNA of myocardium and cardiac function in patients with heart failure].

ADRB1 ADRB2 ADRB3

1.13e-08379315932670
Pubmed

Trp64Arg polymorphism in ADRB3 gene is associated with elite endurance performance.

ADRB1 ADRB2 ADRB3

1.13e-08379319553224
Pubmed

Activation of the Thiazide-Sensitive Sodium-Chloride Cotransporter by Beta3-Adrenoreceptor in the Distal Convoluted Tubule.

ADRB1 ADRB2 ADRB3

1.13e-08379334483955
Pubmed

Variants in the human beta 1-, beta 2-, and beta 3-adrenergic receptor genes are not associated with morbid obesity in children and adolescents.

ADRB1 ADRB2 ADRB3

1.13e-08379315479221
Pubmed

betaAR signaling required for diet-induced thermogenesis and obesity resistance.

ADRB1 ADRB2 ADRB3

1.13e-08379312161655
Pubmed

Role of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout mice.

ADRB1 ADRB2 ADRB3

1.13e-08379321138422
Pubmed

Uroguanylin Action in the Brain Reduces Weight Gain in Obese Mice via Different Efferent Autonomic Pathways.

ADRB1 ADRB2 ADRB3

1.13e-08379326566631
Pubmed

Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.

ADRB1 ADRB2 ADRB3

1.13e-08379323473322
Pubmed

Adrenergic beta1 receptor polymorphism (Ser49Gly) is associated with obesity in type II diabetic patients.

ADRB1 ADRB2 ADRB3

1.13e-08379318239290
Pubmed

Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout mice.

ADRB1 ADRB2 ADRB3

1.13e-08379315939797
Pubmed

Association of beta-adrenergic receptor polymorphisms and progression to heart failure in patients with idiopathic dilated cardiomyopathy.

ADRB1 ADRB2 ADRB3

1.13e-08379315464701
Pubmed

Identification of a signal-responsive nuclear export sequence in class II histone deacetylases.

HDAC5 HDAC4 HDAC7

1.13e-08379311509672
Pubmed

Control of 4E-BP1 expression in mouse brown adipose tissue by the beta3-adrenoceptor.

ADRB1 ADRB2 ADRB3

1.13e-08379315474034
Pubmed

Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity.

ADRB1 ADRB2 ADRB3

1.13e-08379319420258
Pubmed

Genetic influences of beta-adrenoceptor polymorphisms on arterial functional changes and cardiac remodeling in hypertensive patients.

ADRB1 ADRB2 ADRB3

1.13e-08379317345787
Pubmed

[Association of beta-adrenoceptor gene polymorphism with resting heart rate].

ADRB1 ADRB2 ADRB3

1.13e-08379317591269
Pubmed

Ghrelin action in the brain controls adipocyte metabolism.

ADRB1 ADRB2 ADRB3

1.13e-08379316767221
Pubmed

A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.

ADRB1 ADRB2 ADRB3

1.13e-08379311854867
Pubmed

Interactive effects between polymorphisms in the beta-adrenergic receptors and longitudinal changes in obesity.

ADRB1 ADRB2 ADRB3

1.13e-08379315833937
Pubmed

The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors.

ATP2A1 ATP2A2 ATP2A3

1.13e-08379316410239
Pubmed

Expression and functional role of beta-adrenoceptors in the human urinary bladder urothelium.

ADRB1 ADRB2 ADRB3

1.13e-08379318311486
Pubmed

Dephosphorylation at a conserved SP motif governs cAMP sensitivity and nuclear localization of class IIa histone deacetylases.

HDAC9 HDAC5 HDAC4

1.13e-08379323297420
Pubmed

A putative beta2-adrenoceptor from the rainbow trout (Oncorhynuchus mykiss). Molecular characterization and pharmacology.

ADRB1 ADRB2 ADRB3

1.13e-08379311737201
Pubmed

Expression of β-adrenergic receptor subtypes in human normal and dilated ureter.

ADRB1 ADRB2 ADRB3

1.13e-08379328756611
Pubmed

Association of beta-adrenoceptor single nucleotide polymorphisms with resting heart rate.

ADRB1 ADRB2 ADRB3

1.13e-08379317270896
Pubmed

Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors.

ADRB1 ADRB2 ADRB3

1.13e-08379310358009
Pubmed

Diverse evolutionary histories for beta-adrenoreceptor genes in humans.

ADRB1 ADRB2 ADRB3

1.13e-08379319576569
Pubmed

Expression of beta adrenergic receptors in mouse oocytes and preimplantation embryos.

ADRB1 ADRB2 ADRB3

1.13e-08379315791602
Pubmed

Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy.

ADRB1 ADRB2 ADRB3

1.13e-08379320406048
Pubmed

Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting.

ADRB1 ADRB2 ADRB3

1.13e-08379312387862
Pubmed

Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines.

ADRB1 ADRB2 ADRB3

1.13e-0837937738011
Pubmed

Stress-induced epinephrine levels compromise murine dermal fibroblast activity through β-adrenoceptors.

ADRB1 ADRB2 ADRB3

1.13e-08379321366703
Pubmed

Total beta-adrenoceptor knockout slows conduction and reduces inducible arrhythmias in the mouse heart.

ADRB1 ADRB2 ADRB3

1.13e-08379323133676
Pubmed

Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study.

ADRB1 ADRB2 ADRB3

1.13e-08379315917856
Pubmed

Kinase signalling in excitatory neurons regulates sleep quantity and depth.

HDAC9 HDAC5 HDAC4 HDAC7

1.20e-081279436477539
Pubmed

Histone deacetylase expression patterns in developing murine optic nerve.

HDAC9 HDAC5 HDAC4 HDAC7

2.43e-081479425011550
Pubmed

Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin.

HDAC9 HDAC5 HDAC4 HDAC7

2.43e-081479415601857
Pubmed

The genetics of NOD-like receptors in Crohn's disease.

NLRP12 NLRP9 NLRP1 NLRP4

2.43e-081479420403135
Pubmed

NALPs: a novel protein family involved in inflammation.

NLRP12 NLRP9 NLRP1 NLRP4

2.43e-081479412563287
Pubmed

Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9.

HDAC9 HDAC5 HDAC4 HDAC7

2.43e-081479421953612
Pubmed

Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis.

HDAC9 HDAC5 HDAC4 HDAC7

2.43e-081479415537544
Pubmed

Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10.

HDAC9 HDAC5 HDAC4 HDAC7

4.39e-081679416873063
Pubmed

β-Adrenergic receptors control brown adipose UCP-1 tone and cold response without affecting its circadian rhythmicity.

ADRB1 ADRB2 ADRB3

4.50e-08479329715048
Pubmed

β3 adrenergic receptor in the kidney may be a new player in sympathetic regulation of renal function.

ADRB1 ADRB2 ADRB3

4.50e-08479327206969
Pubmed

Somatic Mutation of NLRP Genes in Gastric and Colonic Cancers.

NLRP9 NLRP1 NLRP4

4.50e-08479334257569
Pubmed

The nongastric H+-K+-ATPases: molecular and functional properties.

ATP2A1 ATP2A2 ATP2A3

4.50e-08479310362770
Pubmed

An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation.

ADRB1 ADRB2 ADRB3

4.50e-08479317446185
Pubmed

Association analyses of adrenergic receptor polymorphisms with obesity and metabolic alterations.

ADRB1 ADRB2 ADRB3

4.50e-08479317512307
Pubmed

Adrenergic gene polymorphisms and cardiovascular risk in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation.

ADRB1 ADRB2 ADRB3

4.50e-08479318331634
Pubmed

[Myocardial hypertrophy in patients with hypertensive disease: the role of genetic polymorphism of beta-adrenoreactive structures].

ADRB1 ADRB2 ADRB3

4.50e-08479320144152
Pubmed

Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling.

ADRB1 ADRB2 ADRB3

4.50e-08479321976502
Pubmed

Adrenoceptor-related decrease in serum triglycerides is independent of PPARα activation.

ADRB1 ADRB2 PPARA

4.50e-08479331230416
Pubmed

Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality.

ADRB1 ADRB2 ADRB3

4.50e-08479318245567
Pubmed

β1, β2, and β3 adrenoceptors and Na+/H+ exchanger regulatory factor 1 expression in human bronchi and their modifications in cystic fibrosis.

ADRB1 ADRB2 ADRB3

4.50e-08479320203292
Pubmed

Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis.

ATP2A1 ATP2A2 ATP2A3

4.50e-08479325110346
Pubmed

Physiological consequences of beta-adrenergic receptor disruption.

ADRB1 ADRB2 ADRB3

4.50e-0847939826121
Pubmed

mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity.

HDAC9 HDAC5 HDAC4

4.50e-08479310748098
Pubmed

Intraocular pressure response to topical beta-blockers associated with an ADRB2 single-nucleotide polymorphism.

ADRB1 ADRB2 ADRB3

4.50e-08479318625943
Pubmed

Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes.

ADRB1 ADRB2 ADRB3

4.50e-0847939305915
Pubmed

Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β2-adrenergic receptor but not by AMPK.

ADRB1 ADRB2 ADRB3

4.50e-08479329123236
Pubmed

HDAC family: What are the cancer relevant targets?

HDAC9 HDAC5 HDAC4 HDAC7

7.36e-081879418824292
Pubmed

Red blood cell β-adrenergic receptors contribute to diet-induced energy expenditure by increasing O2 supply.

ADRB1 ADRB2 ADRB3

1.12e-07579328724789
Pubmed

A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP.

HDAC5 HDAC4 HDAC7

1.12e-07579317379597
Pubmed

[Genetic predisposition to development of atrial fibrillation in patients with hypertensive disease].

ADRB1 ADRB2 ADRB3

1.12e-07579320831043
Pubmed

The central melanocortin system directly controls peripheral lipid metabolism.

ADRB1 ADRB2 ADRB3

1.12e-07579317885689
Pubmed

Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases.

HDAC9 HDAC5 HDAC7

1.12e-07579320188095
Pubmed

Sympathetic Nerve Activity Maintains an Anti-Inflammatory State in Adipose Tissue in Male Mice by Inhibiting TNF-α Gene Expression in Macrophages.

ADRB1 ADRB2 ADRB3

1.12e-07579326132918
Pubmed

GDF15 promotes weight loss by enhancing energy expenditure in muscle.

ADRB1 ADRB2 ADRB3

1.12e-07579337380764
Pubmed

Whole-tissue 3D imaging reveals intra-adipose sympathetic plasticity regulated by NGF-TrkA signal in cold-induced beiging.

ADRB1 ADRB2 ADRB3

1.12e-07579329589323
Pubmed

The control of UCP1 is dissociated from that of PGC-1alpha or of mitochondriogenesis as revealed by a study using beta-less mouse brown adipocytes in culture.

ADRB1 ADRB2 ADRB3

1.12e-07579316876797
Pubmed

Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits.

ADRB1 ADRB2 ADRB3

1.12e-07579329514069
Pubmed

Myocyte enhancer factor 2 and class II histone deacetylases control a gender-specific pathway of cardioprotection mediated by the estrogen receptor.

HDAC9 HDAC5 HDAC4

1.12e-07579319893013
Pubmed

Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4.

HDAC9 HDAC5 HDAC4

1.12e-07579318332106
Pubmed

The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.

OSBPL1A ATP2A1 ATP2A2 ATP2A3

1.75e-072279428890335
Pubmed

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.

HDAC5 HDAC4 ATP2A1 ATP2A2 HDAC7

2.22e-075879521884692
Pubmed

A dynamic role for HDAC7 in MEF2-mediated muscle differentiation.

HDAC5 HDAC4 HDAC7

2.24e-07679311279209
Pubmed

Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis.

HDAC5 HDAC4 HDAC7

2.24e-07679318339811
Pubmed

Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor.

HDAC5 HDAC4 HDAC7

2.24e-07679311929873
Pubmed

Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation.

HDAC9 HDAC5 HDAC4

2.24e-07679316356933
Pubmed

Association between polymorphisms in candidate genes and morbid obesity.

ADRB2 ADRB3 PPARA

2.24e-07679311466580
Pubmed

Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin.

ADRB1 ADRB2 ADRB3

2.24e-07679324011077
Pubmed

New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases.

HDAC5 HDAC4 HDAC7

2.24e-07679316980613
Pubmed

HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells.

HDAC9 HDAC5 HDAC7

2.24e-07679319351956
Pubmed

Synopsis and data synthesis of genetic association studies in hypertension for the adrenergic receptor family genes: the CUMAGAS-HYPERT database.

ADRB1 ADRB2 ADRB3

2.24e-07679320044737
Pubmed

A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.

HDAC5 HDAC4 HDAC7

2.24e-07679335076395
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MRE11 RIF1 FASN PELP1 SUPT6H RRP9 HELZ2 ELP1 MACF1 ATP2A2 VIRMA

2.67e-07653791122586326
Pubmed

A microarray minisequencing system for pharmacogenetic profiling of antihypertensive drug response.

ADRB1 ADRB2 ADRB3 PPARA

3.01e-072579412544508
InteractionAHRR interactions

HDAC5 HDAC4 VIRMA

1.86e-067773int:AHRR
InteractionCYREN interactions

MRE11 NHEJ1 VIRMA TOP3B

2.76e-0626774int:CYREN
InteractionFHIP1A interactions

SNX30 MYO6 AP4B1 VIRMA

7.41e-0633774int:FHIP1A
InteractionBTBD7 interactions

FASN VIRMA TOP3B

8.66e-0611773int:BTBD7
InteractionZCCHC14 interactions

FASN VIRMA TOP3B MEX3B

1.18e-0537774int:ZCCHC14
InteractionSLC52A2 interactions

FASN ADRB2 TOP3B

1.49e-0513773int:SLC52A2
InteractionZNF236 interactions

FASN VIRMA TOP3B

1.89e-0514773int:ZNF236
InteractionFRY interactions

HDAC5 HDAC4 VIRMA

2.90e-0516773int:FRY
InteractionRAB43 interactions

MRE11 TRAPPC11 VIRMA TOP3B

3.10e-0547774int:RAB43
InteractionPIEZO1 interactions

ATP2A1 ATP2A3 VIRMA TOP3B

3.10e-0547774int:PIEZO1
InteractionTOP3B interactions

SNX30 FASN HDAC4 PELP1 MYO6 MEX3D HELZ2 LMTK2 RHOT2 PPARA FAAP100 ATP2A3 SH2B2 HDAC7 TOP3B MEX3B ADCY9

3.14e-0514707717int:TOP3B
InteractionBCL2 interactions

MEX3D NLRP1 PPARA ATP2A2 ATP2A3 VIRMA

3.77e-05163776int:BCL2
InteractionNRIP1 interactions

HDAC9 HDAC5 KLHL7 MACF1 PPARA VIRMA

4.77e-05170776int:NRIP1
InteractionMEF2C interactions

HDAC9 HDAC5 HDAC4 HDAC7

5.39e-0554774int:MEF2C
InteractionREV3L interactions

PMS1 HDAC4 VIRMA TOP3B

6.22e-0556774int:REV3L
InteractionNCOR2 interactions

ADRB2 HDAC5 HDAC4 PPARA VIRMA HDAC7 TOP3B

6.73e-05264777int:NCOR2
InteractionDTX4 interactions

HLTF VIRMA NLRP4

7.84e-0522773int:DTX4
InteractionMFSD2A interactions

FASN ADRB2

8.60e-054772int:MFSD2A
InteractionSLC2A4RG interactions

HDAC5 TOP3B

8.60e-054772int:SLC2A4RG
InteractionDISP2 interactions

VIRMA TOP3B

8.60e-054772int:DISP2
InteractionHSD17B4 interactions

FASN ADRB2 HDAC5 TESMIN LMTK2 RHOT2

8.83e-05190776int:HSD17B4
InteractionCDC5L interactions

PMS1 MRE11 NSUN5 RIF1 PARP4 FASN HDAC5 HDAC4 HLTF ELP1 MACF1 VIRMA

9.13e-058557712int:CDC5L
InteractionMCF2L interactions

HDAC4 VIRMA TOP3B

1.02e-0424773int:MCF2L
InteractionINPP4A interactions

FASN HDAC4 VIRMA

1.02e-0424773int:INPP4A
InteractionZFX interactions

FASN HDAC4 VIRMA

1.02e-0424773int:ZFX
InteractionSIRT7 interactions

MRE11 RIF1 FASN PELP1 SUPT6H RRP9 HELZ2 ELP1 MACF1 ATP2A2 VIRMA

1.17e-047447711int:SIRT7
InteractionHELZ2 interactions

HELZ2 PPARA VIRMA TOP3B

1.26e-0467774int:HELZ2
InteractionBAHD1 interactions

FASN HDAC5 VIRMA TOP3B

1.26e-0467774int:BAHD1
InteractionTPTE interactions

ADRB2 RHOT2 ATP2A1 ATP2A2 ADCY9

1.36e-04129775int:TPTE
InteractionCLMN interactions

HDAC4 ATP2A1 VIRMA ADCY9

1.41e-0469774int:CLMN
InteractionSNX30 interactions

SNX30 VIRMA TOP3B

1.47e-0427773int:SNX30
InteractionGPR45 interactions

ECHDC3 EDEM3 RIF1 TNPO2 HLTF RHOT2 ATP2A3

1.49e-04300777int:GPR45
InteractionITPR3 interactions

TACO1 RHOT2 ATP2A1 ATP2A2 VIRMA TOP3B

1.57e-04211776int:ITPR3
InteractionULK4 interactions

RHOT2 VIRMA TOP3B

1.64e-0428773int:ULK4
InteractionTRIM56 interactions

FASN HDAC4 VIRMA TOP3B MEX3B

1.80e-04137775int:TRIM56
InteractionTNRC6C interactions

TNPO2 RHOT2 VIRMA TOP3B MEX3B

1.86e-04138775int:TNRC6C
InteractionFAM162A interactions

ADRB2 ATP2A1 ATP2A3 VIRMA

2.05e-0476774int:FAM162A
InteractionMEF2A interactions

HDAC9 HDAC5 HDAC4 HDAC7

2.05e-0476774int:MEF2A
InteractionADRB3 interactions

ADRB2 ADRB3

2.14e-046772int:ADRB3
InteractionFZD7 interactions

ATP2A3 VIRMA TOP3B ADGRG6

2.16e-0477774int:FZD7
InteractionUBN1 interactions

RIF1 FASN VIRMA TOP3B

2.16e-0477774int:UBN1
InteractionZBED4 interactions

FASN VIRMA TOP3B

2.23e-0431773int:ZBED4
InteractionPLXND1 interactions

MACF1 VIRMA TOP3B

2.23e-0431773int:PLXND1
InteractionIRS1 interactions

ATP2A1 ATP2A2 ATP2A3 VIRMA TOP3B

2.34e-04145775int:IRS1
InteractionBCL6 interactions

HDAC9 HDAC5 HDAC4 OSBPL1A HELZ2 HDAC7

2.44e-04229776int:BCL6
InteractionAP4S1 interactions

HLTF AP4B1 TOP3B

2.46e-0432773int:AP4S1
InteractionGRIK2 interactions

FASN HDAC4 VIRMA

2.46e-0432773int:GRIK2
InteractionTMEM143 interactions

ATP2A1 ATP2A3 ADCY9

2.46e-0432773int:TMEM143
InteractionCLASP2 interactions

FASN ADRB2 HDAC4 VIRMA TOP3B

2.50e-04147775int:CLASP2
InteractionLRRC8B interactions

HDAC4 ATP2A3 VIRMA

2.69e-0433773int:LRRC8B
InteractionLINC00839 interactions

RIF1 MEX3D FAAP100 MEX3B

2.88e-0483774int:LINC00839
InteractionANKRA2 interactions

HDAC9 HDAC5 HDAC4

2.95e-0434773int:ANKRA2
InteractionAKNA interactions

VIRMA TOP3B

2.99e-047772int:AKNA
InteractionBCORL1 interactions

HDAC5 HDAC4 VIRMA HDAC7

3.15e-0485774int:BCORL1
InteractionIKZF4 interactions

HDAC5 HDAC4 HDAC7

3.50e-0436773int:IKZF4
InteractionANKRD11 interactions

HDAC5 HDAC4 PPARA VIRMA TOP3B

3.59e-04159775int:ANKRD11
InteractionPRR12 interactions

FASN HDAC4 VIRMA TOP3B

3.60e-0488774int:PRR12
InteractionTRIB3 interactions

FASN HDAC4 HELZ2 PPARA TOP3B

3.69e-04160775int:TRIB3
GeneFamilyHistone deacetylases, class IIA

HDAC9 HDAC5 HDAC4 HDAC7

8.88e-114574992
GeneFamilyNLR family

NLRP12 NLRP9 NLRP1 NLRP4

1.07e-0625574666
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP12 NLRP9 NLRP1 NLRP4

1.07e-0625574994
GeneFamilyATPases Ca2+ transporting

ATP2A1 ATP2A2 ATP2A3

2.46e-0695731209
GeneFamilyAdrenoceptors

ADRB1 ADRB2 ADRB3

2.46e-069573169
GeneFamilyUPF1 like RNA helicases

IGHMBP2 HELZ2

5.27e-04115721169
GeneFamilyRing finger proteins

MEX3D HLTF MEX3B RNF157

1.10e-0227557458
CoexpressionNRL_DN.V1_DN

QSOX1 ADRB1 ADRB2 TNPO2 GREB1 ATP2A1

2.99e-06132796M2797
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ARFGEF3 SNX30 FASN LMTK2 SLC26A9 ADCY9

1.27e-0619479697534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellCOVID-19_Mild-Neu_2|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients

ARFGEF3 MRE11 KLHL7 DHX32 RNF157

1.38e-05172795f5fd08b42c002d4693646b27e7b708eceb49524f
ToppCellP28-Hematopoietic-Erythroid|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

IGHMBP2 AP4B1 ATP2A1 FAAP100

1.46e-0583794e548e5c7b16c895b360a00f3d6fc1a7eb3d19294
ToppCellP28-Hematopoietic-Erythroid-enucleate_erythrocyte|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

IGHMBP2 AP4B1 ATP2A1 FAAP100

1.46e-0583794c7ff56d4c7582fc497057cf3d5497fbd13c183cc
ToppCellfacs-Spleen-nan-3m-Lymphocytic-B_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNX30 MACF1 ATP2A3 LYPD8 PXK

2.07e-051877953ca3954f45f167e98a230f2847f0582d74fcd32e
ToppCellControl-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

ZFYVE28 ADRB1 GVINP1 MYO6 ATP2A3

2.12e-0518879588b3415e33db81726dd29c1f50c886e057af50a0
ToppCellCOVID-19-lung-AT2|COVID-19 / Disease (COVID-19 only), tissue and cell type

ARFGEF3 SNX30 FASN MEGF9 SLC26A9

2.23e-0519079527a1a86620fe9b5ee930d388b32352206485e6d0
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

ARFGEF3 SNX30 FASN MEGF9 SLC26A9

2.29e-05191795276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARFGEF3 SNX30 FASN MYO6 SLC26A9

2.40e-05193795fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARFGEF3 SNX30 FASN MYO6 SLC26A9

2.40e-05193795f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARFGEF3 SNX30 FASN MEGF9 SLC26A9

2.52e-05195795d9694db6bf239636d1335016878c98f6ee2eb0eb
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIF1 MYO6 MACF1 ATP2A2 ATP2A3

2.52e-051957953e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIF1 MYO6 MACF1 ATP2A2 ATP2A3

2.52e-051957957796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARFGEF3 SNX30 FASN MEGF9 SLC26A9

2.78e-051997952dc33804f6691d7c9682e6c9b885e945fb97fc36
Drugarbutamine

ADRB1 ADRB2 ADRB3

4.02e-083793ctd:C076559
DrugN-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide

ADRB1 ADRB2 ADRB3

4.02e-083793ctd:C568515
Drug3-iodopindolol

ADRB1 ADRB2 ADRB3

4.02e-083793CID000123825
Drugp-azidobenzylcarazolol

ADRB1 ADRB2 ADRB3

4.02e-083793CID000133262
DrugFenoterol

ADRB1 ADRB2 ADRB3

4.02e-083793DB01288
DrugLCB 2183

ADRB1 ADRB2 ADRB3

4.02e-083793CID000133046
DrugU-43,465F

ADRB1 ADRB2 ADRB3

4.02e-083793CID000134388
DrugArbutamine

ADRB1 ADRB2 ADRB3

4.02e-083793DB01102
Drugbroxaterol

ADRB1 ADRB2 ADRB3

4.02e-083793ctd:C045916
DrugpBABC

ADRB1 ADRB2 ADRB3

4.02e-083793CID000126676
DrugEXP063

ADRB1 ADRB2 ADRB3

4.02e-083793CID003037493
DrugICYP-azide-2

ADRB1 ADRB2 ADRB3

4.02e-083793CID003036190
DrugBAM-CYP

ADRB1 ADRB2 ADRB3

4.02e-083793CID000125252
Drugbutofilolol

ADRB1 ADRB2 ADRB3

4.02e-083793CID000068838
Drugsoquinolol

ADRB1 ADRB2 ADRB3

4.02e-083793CID000068811
DrugCS 476

ADRB1 ADRB2 ADRB3

4.02e-083793CID000100459
Drugexaprolol

ADRB1 ADRB2 ADRB3

4.02e-083793CID000065484
DrugAHR-9377

ADRB1 ADRB2 ADRB3

4.02e-083793CID000054961
Drugdicyclopropyl ketoxime

ADRB1 ADRB2 ADRB3

4.02e-083793CID000015072
DrugOberadilol

ADRB1 ADRB2 ADRB3

4.02e-083793CID003047798
DrugCGP-12177-NBD

ADRB1 ADRB2 ADRB3

4.02e-083793CID003081105
DrugBupranolol

ADRB1 ADRB2 ADRB3

4.02e-083793DB08808
Drugp-azidoclonidine

ADRB1 ADRB2 ADRB3

4.02e-083793CID003035819
DrugICYP-azide-1

ADRB1 ADRB2 ADRB3

4.02e-083793CID000133837
DrugAC1L4W2Z

ADRB1 ADRB2 ADRB3

4.02e-083793CID000193350
DrugH 216/44

ADRB1 ADRB2 ADRB3

4.02e-083793CID000130141
DrugAC1L1TT8

ADRB1 ADRB2 ADRB3

4.02e-083793CID000060729
DrugADATN

ADRB1 ADRB2 ADRB3

4.02e-083793CID000133861
Drugbopindolol

NLRP12 ADRB1 ADRB2 ADRB3

9.37e-0813794CID000044112
Drugv315

ADRB1 ADRB2 ADRB3

1.60e-074793CID000053925
DrugNHNPNBE

ADRB1 ADRB2 ADRB3

1.60e-074793CID006453817
Drugeclanamine

ADRB1 ADRB2 ADRB3

1.60e-074793CID000051228
DrugTobanum

ADRB1 ADRB2 ADRB3

1.60e-074793CID000065814
Drugflestolol

ADRB1 ADRB2 ADRB3

1.60e-074793CID000055884
DrugDAPN

ADRB1 ADRB2 ADRB3

1.60e-074793CID000125184
DrugSOM-1122

ADRB1 ADRB2 ADRB3

1.60e-074793CID000068918
Drugtienoxolol

ADRB1 ADRB2 ADRB3

1.60e-074793CID000065678
DrugAlp-NBD

ADRB1 ADRB2 ADRB3

1.60e-074793CID000126953
Drugi 583

ADRB1 ADRB2 ADRB3

1.60e-074793CID000072881
Drugcyanopindolol

ADRB1 ADRB2 ADRB3

1.60e-074793ctd:C047975
Drugacebutolol azide

ADRB1 ADRB2 ADRB3

1.60e-074793CID000133410
DrugCGP 20712A

ADRB1 ADRB2 ADRB3

1.60e-074793ctd:C049763
Drugiodoazidobenzylpindolol

ADRB1 ADRB2 ADRB3

1.60e-074793CID000132676
Drugi-Pr

NLRP12 ADRB1 ADRB2 ADRB3 NLRP4 ADCY9

2.04e-0773796CID000448400
DrugU754

ADRB1 ADRB2 ADRB3 ADCY9

3.09e-0717794CID000062824
Drugsynephrine

ADRB1 ADRB2 ADRB3 AFM

3.96e-0718794CID000007172
DrugHHCA

ADRB1 ADRB2 ADRB3

4.00e-075793CID009576894
DrugPropranolol

ADRB1 ADRB2 ADRB3

4.00e-075793DB00571
Drugoxyfedrine

ADRB1 ADRB2 ADRB3

4.00e-075793CID000027454
Drugms-27

HDAC9 HDAC5 HDAC4

4.00e-075793CID016122504
DrugClenbuterol

ADRB1 ADRB2 ADRB3

4.00e-075793DB01407
DrugAC1Q7AC1

ADRB1 ADRB2 ADRB3

4.00e-075793CID000122310
Drugfluorocarazolol

ADRB1 ADRB2 ADRB3

4.00e-075793CID000133038
DrugS 9871

ADRB1 ADRB2 ADRB3

4.00e-075793CID003036124
Drug6-Hdpei

ADRB1 ADRB2 ADRB3

4.00e-075793CID000137395
DrugDJ-7141

ADRB1 ADRB2 ADRB3

4.00e-075793CID000174123
Drug2,6-DMC

ADRB1 ADRB2 ADRB3

4.00e-075793CID000078576
DrugNF503

ADRB1 ADRB2 ADRB3

4.00e-075793CID005311251
DrugMPV-2426

ADRB1 ADRB2 ADRB3

4.00e-075793CID006433097
DrugBopindolol

ADRB1 ADRB2 ADRB3

4.00e-075793DB08807
DrugNA--can

ADRB1 ADRB2 ADRB3

4.00e-075793CID000007387
Drugsibenadet

ADRB1 ADRB2 ADRB3

4.00e-075793CID000183811
Drugpafenolol

ADRB1 ADRB2 ADRB3

4.00e-075793CID000071144
Druglidamidine

ADRB1 ADRB2 ADRB3

4.00e-075793CID000047509
DrugNSC3852

HDAC9 HDAC4 NLRP1 HDAC7

6.23e-0720794CID000019103
DrugLY 171555

ADRB1 ADRB2 ADRB3 HDAC5 HDAC4 NLRP1 ADCY9

6.31e-07142797CID000001257
Drug6-fluoronorepinephrine

ADRB1 ADRB2 ADRB3 ADCY9

7.68e-0721794CID000001862
Drugreproterol

ADRB1 ADRB2 ADRB3 ADCY9

7.68e-0721794CID000025654
Drugbevantolol

ADRB1 ADRB2 ADRB3

7.98e-076793CID000002372
DrugBr-pindolol

ADRB1 ADRB2 ADRB3

7.98e-076793CID000125847
DrugHUK 978

ADRB1 ADRB2 ADRB3

7.98e-076793CID000065826
Drug2-fluoronorepinephrine

ADRB1 ADRB2 ADRB3

7.98e-076793CID000172745
Drug4-hydroxyclonidine

ADRB1 ADRB2 ADRB3

7.98e-076793CID000092660
Drug1-(benzofuran-7-yl)piperazine

ADRB1 ADRB2 ADRB3

7.98e-076793CID010465458
Drugindenolol

ADRB1 ADRB2 ADRB3

7.98e-076793CID000071955
DrugTA-2005

ADRB1 ADRB2 ADRB3

7.98e-076793CID000063951
Drugadaprolol

ADRB1 ADRB2 ADRB3

7.98e-076793CID000060732
Drugbroxaterol

ADRB1 ADRB2 ADRB3

7.98e-076793CID000071149
Drugmilrinone

ADRB1 ADRB2 ADRB3 ATP2A1 ATP2A2 ATP2A3 ADCY9

9.12e-07150797CID000004197
DrugDCCD

ADRB1 ADRB2 ADRB3 ATP2A1 ATP2A2 ATP2A3 ADCY9

9.54e-07151797CID000010868
Druglanthanum chloride hydrate

ADRB2 ATP2A1 ATP2A2 ATP2A3

1.13e-0623794CID000165791
Drugtrimetoquinol

ADRB1 ADRB2 ADRB3 ADCY9

1.35e-0624794CID000005581
Drugmedroxalol

ADRB1 ADRB2 ADRB3

1.39e-067793CID000041835
Drugmetipranolol

ADRB1 ADRB2 ADRB3

1.39e-067793CID000031477
Drugbornaprolol

ADRB1 ADRB2 ADRB3

1.39e-067793CID000068863
Drugamidephrine

ADRB1 ADRB2 ADRB3

1.39e-067793CID000015009
Drugtazolol

ADRB1 ADRB2 ADRB3

1.39e-067793CID000071720
DrugOxprenolol

ADRB1 ADRB2 ADRB3

1.39e-067793ctd:D010096
DrugIsoproterenol

ADRB1 ADRB2 ADRB3

1.39e-067793DB01064
Drugarbutamine

ADRB1 ADRB2 ADRB3

1.39e-067793CID000060789
DrugD-triiodothyronine

FASN ADRB1 ADRB2 ADRB3 MYO6 PPARA ATP2A1 ATP2A2 ATP2A3 SLC2A5

1.50e-064097910CID000000861
DrugAC1L1G3W

NLRP12 ADRB1 ADRB2 ADRB3 NLRP1 ATP2A1 ATP2A2 ATP2A3

1.69e-06237798CID000003514
Drugmetaproterenol

ADRB1 ADRB2 ADRB3 ADCY9

1.89e-0626794CID000004086
Drugtheophylline

HDAC9 ADRB1 ADRB2 ADRB3 HDAC5 HDAC4 HDAC7 ADCY9

1.92e-06241798CID000002153
Drughexoprenaline

ADRB1 ADRB2 ADRB3

2.22e-068793CID000003609
Drugsoterenol

ADRB1 ADRB2 ADRB3

2.22e-068793CID000026162
Drugpirbuterol

ADRB1 ADRB2 ADRB3

2.22e-068793CID000004845
DrugHOKU-81

ADRB1 ADRB2 ADRB3

2.22e-068793CID000162846
Drugacrinor

ADRB1 ADRB2 ADRB3

2.22e-068793CID005489637
Drugrimiterol

ADRB1 ADRB2 ADRB3

2.22e-068793CID000036283
DiseaseBrody myopathy (implicated_via_orthology)

ATP2A1 ATP2A2 ATP2A3

1.78e-083783DOID:0050692 (implicated_via_orthology)
Diseaseheart disease (implicated_via_orthology)

FBN1 ATP2A1 ATP2A2 ATP2A3

3.11e-0638784DOID:114 (implicated_via_orthology)
DiseaseMalignant neoplasm of breast

MRE11 RIF1 FASN NLRP9 HDAC4 KCNT2 RRP9 ELP1 MACF1 DHX32 ATP2A3 HDAC7 SLC2A5

4.50e-0610747813C0006142
DiseaseCongestive heart failure

FASN ADRB1 ADRB3 ATP2A1 ATP2A2

1.12e-05110785C0018802
DiseaseHeart failure

FASN ADRB1 ADRB3 ATP2A1 ATP2A2

1.12e-05110785C0018801
DiseaseLeft-Sided Heart Failure

FASN ADRB1 ADRB3 ATP2A1 ATP2A2

1.12e-05110785C0023212
DiseaseHeart Failure, Right-Sided

FASN ADRB1 ADRB3 ATP2A1 ATP2A2

1.12e-05110785C0235527
DiseaseHeart Decompensation

FASN ADRB1 ADRB3 ATP2A1 ATP2A2

1.12e-05110785C1961112
DiseaseMyocardial Failure

FASN ADRB1 ADRB3 ATP2A1 ATP2A2

1.12e-05110785C1959583
DiseaseLipidemias

ADRB2 ADRB3 PPARA

1.18e-0517783C1706412
DiseaseHyperlipidemia

ADRB2 ADRB3 PPARA

1.18e-0517783C0020473
Diseaseperiodontitis (implicated_via_orthology)

ADRB1 PPARA

2.07e-053782DOID:824 (implicated_via_orthology)
Diseasecystic fibrosis (is_marker_for)

ADRB1 ADRB2 ADRB3 PPARA

2.24e-0562784DOID:1485 (is_marker_for)
Diseasescoliosis (is_implicated_in)

FBN1 ELP1

4.12e-054782DOID:0060249 (is_implicated_in)
Diseaseabdominal obesity-metabolic syndrome 1 (implicated_via_orthology)

TP53INP1 ATP2A2

6.86e-055782DOID:14221 (implicated_via_orthology)
Diseaseblood pressure, chronic obstructive pulmonary disease

HDAC9 HDAC7 ADGRG6

8.34e-0532783EFO_0000341, EFO_0004325
DiseaseHydrops Fetalis, Non-Immune

ASAH1 THSD1

1.44e-047782C0455988
DiseasePulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia

HDAC5 HDAC4

1.44e-047782C3714844
DiseasePulmonary Hypertension, Primary, 1

HDAC5 HDAC4

1.44e-047782C4552070
DiseasePULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED

HDAC5 HDAC4

1.44e-047782C1969342
DiseasePulmonary Hypertension, Primary, Fenfluramine-Associated

HDAC5 HDAC4

1.44e-047782C1969343
Diseasecongestive heart failure (implicated_via_orthology)

ADRB1 ADRB2 ATP2A2

1.76e-0441783DOID:6000 (implicated_via_orthology)
DiseaseStreptozotocin Diabetes

ADRB3 PPARA ATP2A2 ATP2A3

1.97e-04108784C0038433
DiseaseDiabetes Mellitus, Experimental

ADRB3 PPARA ATP2A2 ATP2A3

1.97e-04108784C0011853
DiseaseAlloxan Diabetes

ADRB3 PPARA ATP2A2 ATP2A3

1.97e-04108784C0002152
DiseaseObesity

FASN ADRB1 ADRB2 ADRB3 PPARA

2.16e-04205785C0028754
DiseaseCardiomyopathy, Dilated

FASN ADRB1 ADRB2

2.82e-0448783C0007193
DiseaseCardiomyopathy, Familial Idiopathic

FASN ADRB1 ADRB2

3.18e-0450783C1449563
Diseasehypertension (biomarker_via_orthology)

FBN1 ADRB1 ADRB2 PPARA ATP2A3

3.45e-04227785DOID:10763 (biomarker_via_orthology)
Diseasemean arterial pressure

HDAC9 EDEM3 ADRB1 HDAC4 UBASH3B ATP2A2 HDAC7

3.56e-04499787EFO_0006340
Diseaseeye measurement, sun exposure measurement

HDAC9 HDAC7

3.74e-0411782EFO_0004731, EFO_0010729
DiseaseMental Depression

HDAC9 ADRB1 HDAC5 HDAC4 ATP2A2

5.75e-04254785C0011570
DiseaseIdiopathic pulmonary arterial hypertension

HDAC5 HDAC4

8.08e-0416782C3203102
DiseaseFamilial primary pulmonary hypertension

HDAC5 HDAC4

9.14e-0417782C0340543
Diseaseglucose homeostasis measurement, acute insulin response measurement

ATP2A2 ATP2A3

1.03e-0318782EFO_0006831, EFO_0006896
Diseaseresponse to selective serotonin reuptake inhibitor

MTMR12 OSBPL1A SLC26A9

1.35e-0382783EFO_0005658
Diseasepolycystic ovary syndrome (biomarker_via_orthology)

ADRB2 ADRB3

1.40e-0321782DOID:11612 (biomarker_via_orthology)
DiseaseMyocardial Reperfusion Injury

ADRB1 PPARA ATP2A2

1.50e-0385783C0027055
DiseaseLynch syndrome (is_implicated_in)

PMS1 MRE11

1.83e-0324782DOID:3883 (is_implicated_in)
Diseasemiddle cerebral artery infarction (biomarker_via_orthology)

HDAC9 HDAC5 HDAC4

1.94e-0393783DOID:3525 (biomarker_via_orthology)
Diseasechronic obstructive pulmonary disease

HDAC9 ADRB2 HDAC4 KLHL7 ATP2A2 ATP2A3 ADGRG6

2.29e-03688787EFO_0000341

Protein segments in the cluster

PeptideGeneStartEntry
CVTASIETLCVIALD

ADRB1

141

P08588
CVTASIETLCVIAVD

ADRB2

116

P07550
CCTLSEEFACVDNLA

AFM

461

P43652
AELASCADLGTLCQA

ADGRG6

366

Q86SQ4
DCCTSLVASDCLLVL

GVINP1

2331

Q7Z2Y8
LLAACSSESRELCFV

AP4B1

281

Q9Y6B7
CVALVLLAAAVSCAV

ASAH1

6

Q13510
VDVLCVTASIETLCA

ADRB3

116

P13945
ASCEFDCVDEVLTIA

DHX32

496

Q7L7V1
VELATICALCNDSSL

ATP2A1

411

O14983
VELATICALCNDSAL

ATP2A3

411

Q93084
LAALDCAEETNSAVC

QSOX1

96

O00391
VSCCELAEEDFLAVS

NSUN5

276

Q96P11
SAALEDCALCQETLS

ZFYVE28

781

Q9HCC9
HDLTAICDASEACVS

HDAC4

976

P56524
ICDASEACVSALLGN

HDAC4

981

P56524
CACRSAAIDSCIAVT

GREB1

551

Q4ZG55
EAAVLRAAVLACQAC

GPR179

376

Q6PRD1
EENASDLCCLISSLV

MTMR12

391

Q9C0I1
ETDTCTACAGTLILE

EDEM3

221

Q9BZQ6
AAAGCQLVASCDIAV

ECHDC3

151

Q96DC8
LTSDCCQDLASVLSA

NLRP1

906

Q9C000
SSAPALARECVVCAE

MEX3D

591

Q86XN8
IANLAATDVTFLLCC

KISS1R

81

Q969F8
LCCAAAAAAAAVASA

MEGF9

21

Q9H1U4
AEVSSSFVILCVCSL

LMTK2

41

Q8IWU2
ESVCVATASGDVILC

ELP1

81

O95163
VDASNCLGISVLAEC

KLHL7

141

Q8IXQ5
CFITAAGCEDLASAL

NLRP4

846

Q96MN2
DDAEACFILSSRCEV

KCNT2

376

Q6UVM3
LASESEVIICLDCSS

PARP4

871

Q9UKK3
EASRETCVALTDCLN

OSBPL1A

406

Q9BXW6
VSSFCSEALVTCAAL

PELP1

616

Q8IZL8
QVLTSSCALDLDSAC

FAAP100

546

Q0VG06
LVTELSSCGFALDLC

MACF1

4281

Q9UPN3
VELATICALCNDSAL

ATP2A2

411

P16615
ATCVDLQLRTCSDAA

CPZ

41

Q66K79
SACIDINECELSAHL

FBN1

1151

P35555
AVSCVCTLLGALDEL

ARFGEF3

426

Q5TH69
CSCAEALLSGFEVID

ADCY9

581

O60503
AVLVAAVESLSCVQC

LYPD8

11

Q6UX82
EECDAVALLSLINSC

CXorf38

131

Q8TB03
ILSSGSDEECAICLD

HLTF

751

Q14527
HDLTAICDASEACVS

HDAC5

1006

Q9UQL6
ICDASEACVSALLSV

HDAC5

1011

Q9UQL6
TAICDASEACVAALL

HDAC7

846

Q8WUI4
HDLTAICDASEACVN

HDAC9

956

Q9UKV0
PARLDSVDACVVAAC

HELZ2

1476

Q9BYK8
ALGSADLLVCNCAVA

FASN

1306

P49327
CCIAEVLITTRTAAD

PMS1

101

P54277
CEEVCILSASGTAAV

C2CD5

421

Q86YS7
DDSDISLFVAAIICC

PPARA

371

Q07869
VEATCACLLAQGEEA

TESMIN

456

Q9Y4I5
RDCSVCFESEVIAAL

MEX3B

516

Q6ZN04
SDNSAECVVCLSDVR

RNF157

271

Q96PX1
VICCALSVTLAVDGA

SLC26A9

386

Q7LBE3
GLLATSLDATCDVAC

RHOT2

476

Q8IXI1
ARCAALVATAEENLC

RIF1

716

Q5UIP0
LDSLGLCSVSCALEF

TACO1

246

Q9BSH4
CCVLTAALALQDTVS

SLC2A5

356

P22732
SEATFSCDCVADALI

NHEJ1

91

Q9H9Q4
DALCALDILSCAGFV

MRE11

136

P49959
ISSEVCEDIASVLAC

NLRP9

726

Q7RTR0
EFAQVCSSDEDILCL

SUPT6H

926

Q7KZ85
VSADTCSVCEAALLD

TOP3B

766

O95985
VDCFSALLSACETRD

PP632

81

Q6XCG6
DVIASERAAALCNAC

TRAPPC11

151

Q7Z392
VSACIGNCSTALEEL

SNX30

301

Q5VWJ9
VAALDALSRECCVTA

RRP9

286

O43818
LTSDNCALLCDAAAA

KBTBD13

101

C9JR72
VVVIDECAQALEASC

IGHMBP2

371

P38935
ASLECLADTSDSCFL

TP53INP1

71

Q96A56
SLEASLCSLEECAAF

THSD1

381

Q9NS62
AACSAFATLEEEACT

TNPO2

496

O14787
RLLCVEFASVASCDA

TDP2

26

O95551
AVVAVLESTLSCEAC

PXK

366

Q7Z7A4
SRVASCSCELLTDAV

SH2B2

326

O14492
EDVALAPCTAAAACE

SNHG28

66

P0DPA3
ILIVAHASSLEACTC

UBASH3B

571

Q8TF42
ICDCLLATLANSESS

VIRMA

1326

Q69YN4
CRLTAAACDELASTL

NLRP12

866

P59046
DTINTSCDIELLAAC

MYO6

1096

Q9UM54