Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	carbonate dehydratase activity	CA14 CA5BP1 CA8	6.90e-05	16	102	3	GO:0004089
GeneOntologyCellularComponent	SREBP-SCAP-Insig complex	INSIG1 INSIG2	6.64e-05	3	99	2	GO:0032937
GeneOntologyCellularComponent	RAVE complex	DMXL2 DMXL1	6.64e-05	3	99	2	GO:0043291
GeneOntologyCellularComponent	heteromeric SMAD protein complex	SMAD3 SMAD6	6.10e-04	8	99	2	GO:0071144
GeneOntologyCellularComponent	SMAD protein complex	SMAD3 SMAD6	9.75e-04	10	99	2	GO:0071141
GeneOntologyCellularComponent	SMN complex	GEMIN8 GEMIN4	1.19e-03	11	99	2	GO:0032797
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	GAD2 DMXL2 DRD2 STAB2 MYO1C GPR84 NEU3 SCAMP3 TBC1D10C PLEKHM2 PLA2G4B HPS6 OSBPL11 SLC17A6 GP2	1.22e-03	1307	99	15	GO:0030659
GeneOntologyCellularComponent	vesicle membrane	GAD2 DMXL2 DRD2 STAB2 MYO1C GPR84 NEU3 SCAMP3 TBC1D10C PLEKHM2 PLA2G4B HPS6 OSBPL11 SLC17A6 GP2	1.39e-03	1325	99	15	GO:0012506
GeneOntologyCellularComponent	Gemini of coiled bodies	GEMIN8 GEMIN4	1.42e-03	12	99	2	GO:0097504
Domain	Rav1p_C	DMXL2 DMXL1	2.73e-05	2	98	2	IPR022033
Domain	INSIG_fam	INSIG1 INSIG2	2.73e-05	2	98	2	IPR025929
Domain	INSIG	INSIG1 INSIG2	2.73e-05	2	98	2	PF07281
Domain	Rav1p_C	DMXL2 DMXL1	2.73e-05	2	98	2	PF12234
Domain	INSIG-1	INSIG1 INSIG2	2.73e-05	2	98	2	IPR009904
Domain	VWC_out	NELL1 FCGBP JAG1	1.28e-04	19	98	3	SM00215
Domain	GPCR_3	TAS1R3 CASR GPR179	1.74e-04	21	98	3	IPR000337
Domain	7tm_3	TAS1R3 CASR GPR179	2.01e-04	22	98	3	PF00003
Domain	G_PROTEIN_RECEP_F3_2	TAS1R3 CASR GPR179	2.01e-04	22	98	3	PS00980
Domain	G_PROTEIN_RECEP_F3_3	TAS1R3 CASR GPR179	2.01e-04	22	98	3	PS00981
Domain	G_PROTEIN_RECEP_F3_1	TAS1R3 CASR GPR179	2.01e-04	22	98	3	PS00979
Domain	G_PROTEIN_RECEP_F3_4	TAS1R3 CASR GPR179	2.01e-04	22	98	3	PS50259
Domain	GPCR_3_C	TAS1R3 CASR GPR179	2.01e-04	22	98	3	IPR017978
Domain	PH-BEACH_dom	WDFY3 NSMAF	7.48e-04	8	98	2	IPR023362
Domain	Dwarfin	SMAD3 SMAD6	7.48e-04	8	98	2	IPR013790
Domain	DWB	SMAD3 SMAD6	7.48e-04	8	98	2	SM00524
Domain	MH2	SMAD3 SMAD6	7.48e-04	8	98	2	PS51076
Domain	MH1	SMAD3 SMAD6	7.48e-04	8	98	2	PS51075
Domain	-	WDFY3 NSMAF	7.48e-04	8	98	2	2.30.29.40
Domain	PH_BEACH	WDFY3 NSMAF	7.48e-04	8	98	2	PS51783
Domain	-	SMAD3 SMAD6	7.48e-04	8	98	2	3.90.520.10
Domain	MAD_homology_MH1	SMAD3 SMAD6	7.48e-04	8	98	2	IPR013019
Domain	MH2	SMAD3 SMAD6	7.48e-04	8	98	2	PF03166
Domain	SMAD_dom_Dwarfin-type	SMAD3 SMAD6	7.48e-04	8	98	2	IPR001132
Domain	BEACH_dom	WDFY3 NSMAF	9.58e-04	9	98	2	IPR000409
Domain	BEACH	WDFY3 NSMAF	9.58e-04	9	98	2	PS50197
Domain	Beach	WDFY3 NSMAF	9.58e-04	9	98	2	PF02138
Domain	-	WDFY3 NSMAF	9.58e-04	9	98	2	1.10.1540.10
Domain	Beach	WDFY3 NSMAF	9.58e-04	9	98	2	SM01026
Domain	VWC	NELL1 FCGBP JAG1	1.03e-03	38	98	3	SM00214
Domain	VWF_dom	NELL1 FCGBP JAG1	1.39e-03	42	98	3	IPR001007
Domain	Growth_fac_rcpt_	STAB2 GPR179 NELL1 CELSR1 JAG1	1.39e-03	156	98	5	IPR009030
Domain	EGF	STAB2 GPR179 NELL1 CELSR1 FCGBP JAG1	1.50e-03	235	98	6	SM00181
Domain	EGF_3	STAB2 NELL1	1.74e-03	12	98	2	PF12947
Domain	MAD_homology1_Dwarfin-type	SMAD3 SMAD6	1.74e-03	12	98	2	IPR003619
Domain	DWA	SMAD3 SMAD6	1.74e-03	12	98	2	SM00523
Domain	EGF_dom	STAB2 NELL1	1.74e-03	12	98	2	IPR024731
Domain	MH1	SMAD3 SMAD6	1.74e-03	12	98	2	PF03165
Domain	EGF-like_dom	STAB2 NELL1 CELSR1 FCGBP JAG1 GP2	2.00e-03	249	98	6	IPR000742
Domain	NCD3G	TAS1R3 CASR	2.05e-03	13	98	2	PF07562
Domain	GPCR_3_9-Cys_dom	TAS1R3 CASR	2.05e-03	13	98	2	IPR011500
Domain	GPCR_3_CS	TAS1R3 CASR	2.38e-03	14	98	2	IPR017979
Domain	Carbonic_anhydrase_a-class	CA14 CA8	2.74e-03	15	98	2	IPR023561
Domain	ALPHA_CA_1	CA14 CA8	2.74e-03	15	98	2	PS00162
Domain	GRAM	TBC1D8B NSMAF	3.12e-03	16	98	2	SM00568
Domain	SMAD_dom-like	SMAD3 SMAD6	3.12e-03	16	98	2	IPR017855
Domain	-	SMAD3 SMAD6	3.12e-03	16	98	2	2.60.200.10
Domain	ALPHA_CA_2	CA14 CA8	3.52e-03	17	98	2	PS51144
Domain	Carb_anhydrase	CA14 CA8	3.52e-03	17	98	2	PF00194
Domain	Carb_anhydrase	CA14 CA8	3.52e-03	17	98	2	SM01057
Domain	-	CA14 CA8	3.52e-03	17	98	2	3.10.200.10
Domain	Carbonic_anhydrase_a	CA14 CA8	3.52e-03	17	98	2	IPR001148
Domain	EGF_extracell	STAB2 NELL1 JAG1	3.86e-03	60	98	3	IPR013111
Domain	EGF_2	STAB2 NELL1 JAG1	3.86e-03	60	98	3	PF07974
Domain	EGF_CA	STAB2 NELL1 CELSR1 JAG1	3.90e-03	122	98	4	SM00179
Domain	EGF-like_Ca-bd_dom	STAB2 NELL1 CELSR1 JAG1	4.14e-03	124	98	4	IPR001881
Domain	GRAM	TBC1D8B NSMAF	5.88e-03	22	98	2	PF02893
Domain	GRAM	TBC1D8B NSMAF	5.88e-03	22	98	2	IPR004182
Domain	ConA-like_dom	RNF135 TRIM7 NELL1 CELSR1 WDFY3	5.95e-03	219	98	5	IPR013320
Domain	HormR	GCGR CELSR1	7.56e-03	25	98	2	SM00008
Pubmed	Association of genetic polymorphisms of glutamate decarboxylase 2 and the dopamine D2 receptor with obesity in Taiwanese subjects.	GAD2 DRD2	8.86e-06	2	104	2	22366823
Pubmed	An insular cortical circuit required for itch sensation and aversion.	GAD2 SLC17A6	8.86e-06	2	104	2	38484733
Pubmed	Monosynaptic inputs to specific cell types of the intermediate and deep layers of the superior colliculus.	GAD2 SLC17A6	8.86e-06	2	104	2	32080842
Pubmed	Divergent neurocircuitry dissociates two components of the stress response: glucose mobilization and anxiety-like behavior.	GAD2 SLC17A6	8.86e-06	2	104	2	36351404
Pubmed	Cdk5 phosphorylates dopamine D2 receptor and attenuates downstream signaling.	DRD2 CDK5	8.86e-06	2	104	2	24391960
Pubmed	Gene-gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics.	INSIG1 INSIG2	8.86e-06	2	104	2	20877301
Pubmed	Genetic factors contributing to autism spectrum disorder in Williams-Beuren syndrome.	MLXIPL UBR5	8.86e-06	2	104	2	31413120
Pubmed	Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine.	INSIG1 INSIG2	8.86e-06	2	104	2	24337570
Pubmed	Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin.	INSIG1 INSIG2	8.86e-06	2	104	2	20090767
Pubmed	Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.	INSIG1 INSIG2	8.86e-06	2	104	2	19638338
Pubmed	Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.	INSIG1 INSIG2	8.86e-06	2	104	2	16955138
Pubmed	Whole-brain connectivity atlas of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei.	GAD2 SLC17A6	8.86e-06	2	104	2	34792021
Pubmed	Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway.	INSIG1 INSIG2	8.86e-06	2	104	2	19360322
Pubmed	The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. The Beijing Atherosclerosis Study.	INSIG1 INSIG2	8.86e-06	2	104	2	18989534
Pubmed	Hypothalamus-habenula potentiation encodes chronic stress experience and drives depression onset.	GAD2 SLC17A6	8.86e-06	2	104	2	35114101
Pubmed	Inhibitory neurons in the superior colliculus mediate selection of spatially-directed movements.	GAD2 SLC17A6	8.86e-06	2	104	2	34117346
Pubmed	The subthalamic corticotropin-releasing hormone neurons mediate adaptive REM-sleep responses to threat.	GAD2 SLC17A6	8.86e-06	2	104	2	35065715
Pubmed	Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.	INSIG1 INSIG2	8.86e-06	2	104	2	19617589
Pubmed	Orexin-driven GAD65 network of the lateral hypothalamus sets physical activity in mice.	GAD2 SLC17A6	8.86e-06	2	104	2	28396414
Pubmed	Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.	INSIG1 INSIG2	8.86e-06	2	104	2	12624180
Pubmed	GAD2 Expression Defines a Class of Excitatory Lateral Habenula Neurons in Mice that Project to the Raphe and Pontine Tegmentum.	GAD2 SLC17A6	2.65e-05	3	104	2	32332079
Pubmed	TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice.	GAD2 SLC17A6	2.65e-05	3	104	2	38518778
Pubmed	Hypothalamic Glutamate/GABA Cotransmission Modulates Hippocampal Circuits and Supports Long-Term Potentiation.	GAD2 SLC17A6	2.65e-05	3	104	2	34380766
Pubmed	Opposing Contributions of GABAergic and Glutamatergic Ventral Pallidal Neurons to Motivational Behaviors.	GAD2 SLC17A6	2.65e-05	3	104	2	31948733
Pubmed	Control of REM sleep by ventral medulla GABAergic neurons.	GAD2 SLC17A6	2.65e-05	3	104	2	26444238
Pubmed	Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations.	GAD2 SLC17A6	2.65e-05	3	104	2	29307710
Pubmed	A subcortical excitatory circuit for sensory-triggered predatory hunting in mice.	GAD2 SLC17A6	2.65e-05	3	104	2	31127260
Pubmed	Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation.	INSIG1 INSIG2	2.65e-05	3	104	2	24806461
Pubmed	Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines.	INSIG1 INSIG2	2.65e-05	3	104	2	16549805
Pubmed	Prefrontal cortical control of a brainstem social behavior circuit.	GAD2 SLC17A6	2.65e-05	3	104	2	28067904
Pubmed	Excitatory and Inhibitory Descending Commissural Interneurons Differentially Integrate Supraspinal and Segmental Sensory Signals.	GAD2 SLC17A6	2.65e-05	3	104	2	37286348
Pubmed	Cholesterol metabolism plays a crucial role in the regulation of autophagy for cell differentiation of granular convoluted tubules in male mouse submandibular glands.	INSIG1 INSIG2	2.65e-05	3	104	2	31558435
Pubmed	Hypothalamic-hindbrain circuit for consumption-induced fear regulation.	GAD2 SLC17A6	2.65e-05	3	104	2	39231981
Pubmed	Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2.	INSIG1 INSIG2	2.65e-05	3	104	2	31953408
Pubmed	Olivocerebellar control of movement symmetry.	GAD2 SLC17A6	2.65e-05	3	104	2	35016009
Pubmed	Repetitive transcranial magnetic stimulation induces long-lasting changes in protein expression and histone acetylation.	DRD2 CDK5	2.65e-05	3	104	2	26585834
Pubmed	Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis.	INSIG1 INSIG2	2.65e-05	3	104	2	34298014
Pubmed	Midbrain circuits for defensive behaviour.	GAD2 SLC17A6	2.65e-05	3	104	2	27279213
Pubmed	Differential Modulation of GABAergic and Glutamatergic Neurons in the Ventral Pallidum by GABA and Neuropeptides.	GAD2 SLC17A6	2.65e-05	3	104	2	37414552
Pubmed	Pin1 protein regulates Smad protein signaling and pulmonary fibrosis.	SMAD3 SMAD6	2.65e-05	3	104	2	22613712
Pubmed	Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.	INSIG1 INSIG2	2.65e-05	3	104	2	12482938
Pubmed	Topological Organization of Ventral Tegmental Area Connectivity Revealed by Viral-Genetic Dissection of Input-Output Relations.	GAD2 SLC17A6	2.65e-05	3	104	2	30605672
Pubmed	Genetic susceptibility to keloid scarring: SMAD gene SNP frequencies in Afro-Caribbeans.	SMAD3 SMAD6	2.65e-05	3	104	2	18445023
Pubmed	Mouse Sertoli cells sustain de novo generation of regulatory T cells by triggering the notch pathway through soluble JAGGED1.	JAG1 SMAD3	2.65e-05	3	104	2	24478388
Pubmed	Locomotor speed control circuits in the caudal brainstem.	GAD2 SLC17A6	2.65e-05	3	104	2	29059682
Pubmed	Distinct lateral hypothalamic CaMKIIα neuronal populations regulate wakefulness and locomotor activity.	GAD2 SLC17A6	2.65e-05	3	104	2	38593074
Pubmed	Glucagon signaling modulates sweet taste responsiveness.	TAS1R3 GCGR	2.65e-05	3	104	2	20547661
Pubmed	Distinct circuits in anterior cingulate cortex encode safety assessment and mediate flexibility of fear reactions.	GAD2 SLC17A6	2.65e-05	3	104	2	37652003
Pubmed	Behavioral actions of alcohol: phenotypic relations from multivariate analysis of mutant mouse data.	GAD2 TAS1R3	2.65e-05	3	104	2	22405477
Pubmed	Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion.	JAG1 SMAD3	2.65e-05	3	104	2	38092725
Pubmed	GABAergic and glutamatergic efferents of the mouse ventral tegmental area.	GAD2 SLC17A6	2.65e-05	3	104	2	24715505
Pubmed	Hindbrain Double-Negative Feedback Mediates Palatability-Guided Food and Water Consumption.	GAD2 SLC17A6	5.29e-05	4	104	2	32841600
Pubmed	Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming.	TFAM JAG1	5.29e-05	4	104	2	30226866
Pubmed	Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population.	INSIG1 INSIG2	5.29e-05	4	104	2	19740467
Pubmed	A neuronal circuit for activating descending modulation of neuropathic pain.	GAD2 SLC17A6	5.29e-05	4	104	2	31501573
Pubmed	Inhibitory gain modulation of defense behaviors by zona incerta.	GAD2 SLC17A6	5.29e-05	4	104	2	29559622
Pubmed	Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.	INSIG1 INSIG2	5.29e-05	4	104	2	15899885
Pubmed	Sex-specific cannabinoid 1 receptors on GABAergic neurons in the ventrolateral periaqueductal gray mediate analgesia in mice.	GAD2 SLC17A6	5.29e-05	4	104	2	35716006
Pubmed	Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion.	TAS1R3 CASR	5.29e-05	4	104	2	20876097
Pubmed	Tagger-A Swiss army knife for multiomics to dissect cell type-specific mechanisms of gene expression in mice.	GAD2 SLC17A6	5.29e-05	4	104	2	31393866
Pubmed	An orbitofrontal cortex to midbrain projection modulates hypersensitivity after peripheral nerve injury.	GAD2 SLC17A6	5.29e-05	4	104	2	33910011
Pubmed	Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice.	GAD2 SLC17A6	5.29e-05	4	104	2	28463228
Pubmed	Intracellular dynamics of Smad-mediated TGFbeta signaling.	SMAD3 SMAD6	5.29e-05	4	104	2	14502566
Pubmed	The pheromone darcin drives a circuit for innate and reinforced behaviours.	GAD2 SLC17A6	5.29e-05	4	104	2	31996852
Pubmed	Transforming growth factor-β1 induces cell cycle arrest by activating atypical cyclin-dependent kinase 5 through up-regulation of Smad3-dependent p35 expression in human MCF10A mammary epithelial cells.	SMAD3 CDK5	5.29e-05	4	104	2	26966064
Pubmed	Control of Non-REM Sleep by Midbrain Neurotensinergic Neurons.	GAD2 SLC17A6	5.29e-05	4	104	2	31582313
Pubmed	Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis.	GAD2 SLC17A6	5.29e-05	4	104	2	32639229
Pubmed	Transforming Sensory Cues into Aversive Emotion via Septal-Habenular Pathway.	GAD2 SLC17A6	5.29e-05	4	104	2	30122379
Pubmed	Transient Receptor Potential Channels TRPM4 and TRPC3 Critically Contribute to Respiratory Motor Pattern Formation but not Rhythmogenesis in Rodent Brainstem Circuits.	TRPM4 SLC17A6	5.29e-05	4	104	2	29435486
Pubmed	A Neural Circuit for the Suppression of Pain by a Competing Need State.	GAD2 SLC17A6	5.29e-05	4	104	2	29570993
Pubmed	A putative loop connection between VTA dopamine neurons and nucleus accumbens encodes positive valence to compensate for hunger.	GAD2 SLC17A6	5.29e-05	4	104	2	37451329
Pubmed	Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs.	INSIG1 INSIG2	5.29e-05	4	104	2	12842885
Pubmed	Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.	INSIG1 INSIG2	5.29e-05	4	104	2	16606821
Pubmed	Endocytosis and intracellular processing of BODIPY-sphingomyelin by murine CATH.a neurons.	SMPD3 NSMAF	5.29e-05	4	104	2	23973266
Pubmed	Neurons with diverse phenotypes project from the caudal to the rostral nucleus of the solitary tract.	GAD2 SLC17A6	5.29e-05	4	104	2	30325514
Pubmed	A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System.	GAD2 SLC17A6	5.29e-05	4	104	2	30503173
Pubmed	Chronic Nicotine Exposure Alters the Neurophysiology of Habenulo-Interpeduncular Circuitry.	GAD2 SLC17A6	5.29e-05	4	104	2	30867261
Pubmed	Expression of GAD2 in excitatory neurons projecting from the ventrolateral periaqueductal gray to the locus coeruleus.	GAD2 SLC17A6	5.29e-05	4	104	2	38868198
Pubmed	Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe.	GAD2 SLC17A6	5.29e-05	4	104	2	31604921
Pubmed	Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development.	GAD2 DRD2 SLC17A6	5.69e-05	25	104	3	30718509
Pubmed	Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon.	GAD2 DRD2 JAG1	6.42e-05	26	104	3	12397111
Pubmed	A thalamic-primary auditory cortex circuit mediates resilience to stress.	GAD2 SLC17A6	8.80e-05	5	104	2	37001500
Pubmed	The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.	NELL1 MGAT5B	8.80e-05	5	104	2	22823124
Pubmed	Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans.	GAD2 SLC17A6	8.80e-05	5	104	2	34473054
Pubmed	Developmentally regulated expression of Smad3, Smad4, Smad6, and Smad7 involved in TGF-beta signaling.	SMAD3 SMAD6	8.80e-05	5	104	2	11231077
Pubmed	Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.	INSIG1 INSIG2	8.80e-05	5	104	2	12242332
Pubmed	A Differential Circuit via Retino-Colliculo-Pulvinar Pathway Enhances Feature Selectivity in Visual Cortex through Surround Suppression.	GAD2 SLC17A6	8.80e-05	5	104	2	31812514
Pubmed	Association of TGFBR2 polymorphism with risk of sudden cardiac arrest in patients with coronary artery disease.	SMAD3 SMAD6	8.80e-05	5	104	2	19959123
Pubmed	Thalamic inhibition regulates critical-period plasticity in visual cortex and thalamus.	GAD2 SLC17A6	8.80e-05	5	104	2	29184199
Pubmed	The p21 codon 31C- and DRD2 codon 313T-related genotypes/alleles, but not XRCC1 codon 399, hOGG1 codon 326, and DRD1-48 polymorphisms, are correlated with the presence of leiomyoma.	DRD2 XRCC1	8.80e-05	5	104	2	19176223
Pubmed	The gene-gene interaction of INSIG-SCAP-SREBP pathway on the risk of obesity in Chinese children.	INSIG1 INSIG2	8.80e-05	5	104	2	25028659
Pubmed	Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.	INSIG1 INSIG2	8.80e-05	5	104	2	29374057
Pubmed	Pain modulates dopamine neurons via a spinal-parabrachial-mesencephalic circuit.	GAD2 SLC17A6	8.80e-05	5	104	2	34373644
Pubmed	Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.	INSIG1 INSIG2	8.80e-05	5	104	2	22143767
Pubmed	Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?	INSIG1 INSIG2	8.80e-05	5	104	2	18195716
Pubmed	Ultra-sparse Connectivity within the Lateral Hypothalamus.	GAD2 SLC17A6	8.80e-05	5	104	2	32822604
Pubmed	Genetic Ablation of GIGYF1, Associated With Autism, Causes Behavioral and Neurodevelopmental Defects in Zebrafish and Mice.	GAD2 SLC17A6	8.80e-05	5	104	2	36924980
Pubmed	A mesocortical glutamatergic pathway modulates neuropathic pain independent of dopamine co-release.	GAD2 SLC17A6	8.80e-05	5	104	2	38245542
Pubmed	A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility.	SMAD3 SMAD6	8.80e-05	5	104	2	24658283
Pubmed	Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.	INSIG1 INSIG2	8.80e-05	5	104	2	16100574
GeneFamily	Gemins	GEMIN8 GEMIN4	1.89e-04	6	65	2	1131
GeneFamily	SMAD family	SMAD3 SMAD6	3.51e-04	8	65	2	750
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDFY3 NSMAF	4.51e-04	9	65	2	1230
GeneFamily	UPF1 like RNA helicases	SETX ZGRF1	6.85e-04	11	65	2	1169
GeneFamily	WD repeat domain containing\|GRAM domain containing\|BEACH domain containing	TBC1D8B NSMAF	9.68e-04	13	65	2	1146
GeneFamily	Carbonic anhydrases	CA14 CA8	1.88e-03	18	65	2	460
GeneFamily	WD repeat domain containing	DMXL2 FBXW10 DMXL1 WDFY3 NSMAF	2.50e-03	262	65	5	362
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	LRRN1 TYRO3 LRFN5 IL1RL1	2.69e-03	161	65	4	593
GeneFamily	Kelch like\|BTB domain containing	ENC1 KLHL25	9.99e-03	42	65	2	617
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM4 DMXL2 MBOAT1 TYRO3 IL1RL1 TEC	3.29e-06	173	104	6	3612772632ddf11eb48579cae9a8ccab6b3f1f52
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM4 DMXL2 MBOAT1 TYRO3 IL1RL1 TEC	3.29e-06	173	104	6	4dc261ebcdb9bdcfca1451da1bd254f0dc5de203
ToppCell	droplet-Lung-nan-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CA14 TM6SF2 JAG1 TRIM37 SMAD6 CA8	5.15e-06	187	104	6	64dd28b23eda7dfb7fd069be2742de7bad0fd87a
ToppCell	droplet-Lung-nan-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CA14 TM6SF2 JAG1 TRIM37 SMAD6 CA8	5.15e-06	187	104	6	b535d5447bf15e95dcf025a0a455628b956fc857
Disease	nephrolithiasis (is_implicated_in)	CASR SLC34A1	3.40e-05	3	100	2	DOID:585 (is_implicated_in)
Disease	SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 1	SETX PIK3R5	3.40e-05	3	100	2	C1853761
Disease	hypercalcemia (is_implicated_in)	CASR SLC34A1	3.40e-05	3	100	2	DOID:12678 (is_implicated_in)
Disease	Chediak-Higashi syndrome (implicated_via_orthology)	WDFY3 NSMAF	6.79e-05	4	100	2	DOID:2935 (implicated_via_orthology)
Disease	tyrosine-protein kinase TEC measurement	TEC TEC	6.79e-05	4	100	2	EFO_0020830
Disease	level of Sphingomyelin (d42:2) in blood serum	TM6SF2 CHRNE MLXIPL	1.29e-04	29	100	3	OBA_2045183
Disease	invasive ductal carcinoma (is_implicated_in)	XRCC1 UBR5	6.13e-04	11	100	2	DOID:3008 (is_implicated_in)
Disease	Familial thoracic aortic aneurysm and aortic dissection	JAG1 SMAD3 SMAD6	7.82e-04	53	100	3	C4707243
Disease	Hypercalcemia	CASR SLC34A1	8.66e-04	13	100	2	C0020437
Disease	Milk-Alkali Syndrome	CASR SLC34A1	8.66e-04	13	100	2	C0026141
Disease	Cocaine Dependence	GAD2 DRD2 SMAD3 CDK5	1.30e-03	139	100	4	C0600427
Disease	Synostotic Posterior Plagiocephaly	NELL1 SMAD6	1.32e-03	16	100	2	C1833340
Disease	Craniosynostosis, Type 1	NELL1 SMAD6	1.32e-03	16	100	2	C4551902
Disease	Acrocephaly	NELL1 SMAD6	1.32e-03	16	100	2	C0030044
Disease	Trigonocephaly	NELL1 SMAD6	1.32e-03	16	100	2	C0265535
Disease	Scaphycephaly	NELL1 SMAD6	1.32e-03	16	100	2	C0265534
Disease	Synostotic Anterior Plagiocephaly	NELL1 SMAD6	1.32e-03	16	100	2	C2931150
Disease	Metopic synostosis	NELL1 SMAD6	1.32e-03	16	100	2	C1860819
Disease	Major Depressive Disorder	GAD2 DRD2 NELL1 IKBKE SLC17A6	1.45e-03	243	100	5	C1269683
Disease	Brachycephaly	NELL1 SMAD6	1.50e-03	17	100	2	C0221356
Disease	rhinitis	IL1RL1 SMAD3	1.50e-03	17	100	2	EFO_0008521
Disease	cystathionine measurement	TEC TEC	1.87e-03	19	100	2	EFO_0010474
Disease	Craniosynostosis	NELL1 SMAD6	2.08e-03	20	100	2	C0010278
Disease	Stomach Carcinoma	TFF1 UBR5	2.29e-03	21	100	2	C0699791
Disease	Acute Lung Injury	TFF1 IL1RL1	2.51e-03	22	100	2	C0242488
Disease	S-7-hydroxywarfarin to S-warfarin ratio measurement	DRD2 TMEM132C NSMAF	2.66e-03	81	100	3	EFO_0803334
Disease	idiopathic pulmonary fibrosis (is_marker_for)	IL1RL1 SMAD6	2.75e-03	23	100	2	DOID:0050156 (is_marker_for)
Disease	non-high density lipoprotein cholesterol measurement	RNF135 TM6SF2 UGT1A4 MLXIPL TAMM41 SLC34A1 INSIG2 SMAD3	2.96e-03	713	100	8	EFO_0005689
Disease	Schizophrenia	GAD2 DRD2 XRCC1 ERVW-1 ZDHHC8 PLA2G4B JAG1 SLC17A6 CDK5	3.10e-03	883	100	9	C0036341

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSRYLPPGTRVCAYW	BAHCC1	1971	Q9P281
WSPYLFQPNDTCIVS	CFI	456	P05156
TTCGIFRNWLYFVPL	ANTXRL	346	A6NF34
YPSSLDCTWTINLPI	CSMD3	2131	Q7Z407
LCTPCQAPTNYSRWV	B4GAT1	291	O43505
RCYSAEVVTLWYRPP	CDK5	156	Q00535
IVICVIWLYTAPPSS	CASR	736	P41180
FAYPCRPQTEITDVW	FBXW10	831	Q5XX13
FSNVAWLPTLIPSYC	DMXL2	756	Q8TDJ6
WLPTLIPSYCLGTYC	DMXL2	761	Q8TDJ6
WLPPELFNCTTISFV	CELSR1	2096	Q9NYQ6
FSNVAWLPTLIPSYC	DMXL1	736	Q9Y485
VTWLPPAIYRSVCAV	CHRNE	136	Q04844
ETCASPPLLTGRYFW	LRFN5	261	Q96NI6
HTNVCFWYIPPSLRT	GAD2	501	Q05329
WLGPRSVPYAVCLVQ	OR52W1	91	Q6IF63
CPTYFKLWRTLSGSP	MAGEC3	81	Q8TD91
LAYCLSQWAPLSRQP	NMS	46	Q5H8A3
VESCFNLPWYLPSAL	GEMIN8	46	Q9NWZ8
VSPQSPNLLTYICPW	GPR179	981	Q6PRD1
FCIPAWTRITSFSPT	NLRP8	1016	Q86W28
CANPSYWAAVRELLP	LRRC61	141	Q9BV99
VWACLQLPRGSPSSY	MYO19	886	Q96H55
LIWRTFTPVYCPSPL	ASB17	131	Q8WXJ9
PLEWSYTLPITCQLS	IKBKE	256	Q14164
PLTHWYQVRCLFQSP	CARM1	411	Q86X55
SFLIYLSEVEWFCPP	MGAT5B	196	Q3V5L5
WCRASGLPNRPYTLT	FAM218A	36	Q96MZ4
WCNLRYCTVPRDPST	GP2	171	P55259
TPANTTANISCPWYL	GCGR	71	P47871
YTSPDFLYIRSWLPC	INSIG1	236	O15503
WSVSRVNSFLPPACL	KIF26A	231	Q9ULI4
CFVYSRATFPPEWAQ	GGACT	116	Q9BVM4
RLGYPSCFTNLWALI	PLA2G4B	391	P0C869
TSPDFLYVRSWLPCI	INSIG2	181	Q9Y5U4
PCYWLVDRLAASFIP	SMPD3	26	Q9NY59
WPIYILVPVVCTCSF	GPR84	156	Q9NQS5
WPLTCPNLSCEYTAI	NELL1	726	Q92832
NISGILLWYPVPCTR	SLC34A1	481	Q06495
IYCPTIDLYNWTAPL	IL1RL1	131	Q01638
AECPQPWRYTAAAVL	KLHL25	476	Q9H0H3
LSSRCPGLQNTIPWY	FCGBP	5261	Q9Y6R7
QERVKTFPSACPYWI	CYP4A22	76	Q5TCH4
PCSEGVTWILFRYPL	CA8	226	P35219
PLQVWITSASAPACY	MDH1B	131	Q5I0G3
CYQRVPWYPTVLTFI	MBOAT1	361	Q6ZNC8
QYRPSDLLCPETYVW	ATE1	421	O95260
AQSLSPTAWSYCPLL	FOXD4L1	341	Q9NU39
SCNDLSQYPVFPWII	NSMAF	326	Q92636
ATCPQPWRYTAAAVL	ENC1	476	O14682
CNIPPVLYSAFTWLG	DRD2	401	P14416
SCRQLFLVPTATTWP	HPS6	196	Q86YV9
TTPPSWDYTRICIQR	CA5BP1	121	Q8WTZ4
LTTPPCYQSVLWTVF	CA14	216	Q9ULX7
VLLFTPCSFVCWYRP	SCAMP3	206	O14828
LYLELWCPTVAPSVV	CFAP74	1226	Q9C0B2
CVCEIRPWFTPQSTY	LRRN1	36	Q6UXK5
RQTFYCVPVPGESTW	MCMBP	126	Q9BTE3
SLPCAYARSILTVPW	OSBPL11	566	Q9BXB4
VLPFSFAWPRSYTLL	JAG1	121	P78504
SQQLLPPWVIYLSCT	PLEKHM2	941	Q8IWE5
PWTTRLSCSLCPQYS	RSPH6A	606	Q9H0K4
RPQPYRWSCERFSTS	RNF135	286	Q8IUD6
CWICLPLNFRPYVSI	ERVW-1	186	Q9UQF0
VYSPPLQVSGLCWRL	TRIM37	296	O94972
VSPLVWCRQVLDYPS	SLAIN2	146	Q9P270
YSRQFITSCPCWLEI	SMAD6	476	O43541
QYLSAPLCVTVWVPR	TMEM132C	511	Q8N3T6
WCPPEVFNYSRFSSK	TEC	531	P42680
LSLPFYISQCWTLGS	PTDSS2	406	Q9BVG9
LLCERASPNSFWQPY	SETD3	161	Q86TU7
IRCSSDWPFQPYLVF	SETX	2286	Q7Z333
VYLPRWFSSVLASCP	TFAM	36	Q00059
WLDQYCSLPALRPTV	MLXIPL	801	Q9NP71
TVRGVPWCFYPNTID	TFF1	61	P04155
LQRRLPHWTSFCVPY	C15orf61	41	A6NNL5
YLNQTPLEAACWSRP	NEU3	346	Q9UQ49
CRSWTFYLLLISQPA	SLC17A6	321	Q9P2U8
SFPLSIWICQPTRYA	UHRF1BP1L	721	A0JNW5
ATCVYFVLWLPSSSP	TMEM86A	21	Q8N2M4
CALWNPTPTGDFIYL	STIL	31	Q15468
VEVALCTWYLVAFPP	TAS1R3	691	Q7RTX0
QYWAVTSPERSPLSC	TRIM7	441	Q9C029
CRWASAPPLYTLIDV	ZSWIM9	56	Q86XI8
LFSAITSWCPPYNLP	WDFY3	216	Q8IZQ1
PFDPTRIYSSSLCLW	TMEM54	146	Q969K7
RFLTWPVPYCSICQE	PIK3R5	111	Q8WYR1
IPIPVARCYTYSWSQ	PIK3R5	281	Q8WYR1
RVPCQGWLYLSTNFL	TBC1D8B	171	Q0IIM8
LQPVTYCEPAFWCSI	SMAD3	221	P84022
YLPEWFLCLFARSLP	TBC1D10C	251	Q8IV04
PRPRLAVTYLCWAFA	TMC4	246	Q7Z404
SLVYWSRCPANSEPT	STAB2	681	Q8WWQ8
VQAARPWEFYPSSSC	PIGZ	76	Q86VD9
PWEFYPSSSCRSVLF	PIGZ	81	Q86VD9
FGNPCVTYLLTEWLP	TAMM41	316	Q96BW9
NPSLAFVRPRWIYSC	XRCC1	601	P18887
SPLLEWLPTLCFYNV	ZGRF1	1906	Q86YA3
FFVFTCPWLTRAVSP	ZDHHC8	31	Q9ULC8
AFFLTIPYLLVPCWA	TM6SF2	171	Q9BZW4
YQCWSADPKQRPSFT	TYRO3	766	Q06418
STTPIWALVLAFFCP	TRPM4	686	Q8TD43
WALVLAFFCPPLIYT	TRPM4	691	Q8TD43
QPERSCIAESPLWYS	ZMYM3	1321	Q14202
RQDLVYFWTSSPSLP	UBR5	2726	O95071
SIPAVFFWRYIPCDL	UGT1A4	166	P22310
EYWLQTCSPFPLLFS	GEMIN4	686	P57678
FLQRYKSLCPETWPT	MYO1C	671	O00159