Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylserine binding

APPL2 SYT5 SYT2 SYT7

1.26e-0473704GO:0001786
GeneOntologyMolecularFunctionlipid binding

APPL2 TEX2 PDZD8 SYT5 AIDA SYT2 FERMT2 SYT7 PXK PACSIN2 EHD3

6.11e-049887011GO:0008289
GeneOntologyMolecularFunctionphospholipid binding

APPL2 SYT5 AIDA SYT2 FERMT2 SYT7 PXK PACSIN2

6.48e-04548708GO:0005543
GeneOntologyMolecularFunctionphosphatidylinositol binding

APPL2 SYT5 AIDA FERMT2 SYT7 PXK

8.39e-04316706GO:0035091
GeneOntologyMolecularFunctionmodified amino acid binding

APPL2 SYT5 SYT2 SYT7

8.91e-04122704GO:0072341
GeneOntologyMolecularFunctioncalcium-dependent phospholipid binding

SYT5 SYT2 SYT7

1.22e-0360703GO:0005544
GeneOntologyMolecularFunctioncalmodulin binding

CAMK4 UBR4 SYT7 RGS4 RYR2

1.28e-03230705GO:0005516
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

EEF1B2 RIN3 DOCK11 FGD5 TIAM2

1.30e-03231705GO:0005085
GeneOntologyMolecularFunctionclathrin binding

SYT5 SYT2 SYT7

1.41e-0363703GO:0030276
GeneOntologyBiologicalProcessmaintenance of protein complex location

TMEM232 EPG5

1.14e-052702GO:0098544
MousePhenoabnormal sperm fibrous sheath morphology

FSIP2 TMEM232 SPAG17 CFAP44

9.42e-0632594MP:0030590
MousePhenoabnormal outer dense fiber morphology

KATNAL2 TMEM232 SPAG17 CFAP44

2.11e-0539594MP:0031356
MousePhenooligozoospermia

ANKRD31 FSIP2 KATNAL2 TMEM232 CAMK4 MEIKIN KIAA0319L SPAG17 CFAP44

3.02e-05384599MP:0002687
MousePhenoabnormal sperm flagellum morphology

FSIP2 KATNAL2 TMEM232 CAMK4 KIAA0319L SPAG17 CFAP44 HERC4

3.12e-05295598MP:0008892
MousePhenoabnormal sperm principal piece morphology

FSIP2 TMEM232 SPAG17 CFAP44

3.75e-0545594MP:0009836
MousePhenoteratozoospermia

ANKRD31 FSIP2 KATNAL2 TMEM232 CAMK4 KIAA0319L SPAG17 CFAP44 HERC4

4.85e-05408599MP:0005578
MousePhenoasthenozoospermia

ANKRD31 FSIP2 KATNAL2 TMEM232 KIAA0319L SPAG17 CFAP44 HERC4

1.31e-04362598MP:0002675
MousePhenoshort sperm flagellum

FSIP2 KATNAL2 SPAG17 CFAP44

1.42e-0463594MP:0009239
MousePhenoabnormal motile cilium morphology

FSIP2 KATNAL2 TMEM232 CAMK4 KIAA0319L SPAG17 CFAP44 HERC4

1.52e-04370598MP:0013206
MousePhenoabnormal inhibitory postsynaptic currents

NRXN2 CAMK4 SYT5 SYT2

2.13e-0470594MP:0002945
MousePhenoabnormal sperm number

ANKRD31 FSIP2 KATNAL2 TMEM232 CAMK4 MEIKIN RXFP2 KIAA0319L SPAG17 CFAP44

2.54e-046245910MP:0002673
MousePhenoabnormal sperm motility

ANKRD31 FSIP2 KATNAL2 TMEM232 KIAA0319L SPAG17 CFAP44 HERC4

2.63e-04401598MP:0002674
MousePhenodecreased male germ cell number

ANKRD31 FSIP2 KATNAL2 TMEM232 CAMK4 MEIKIN RXFP2 KIAA0319L SPAG17 CFAP44

3.11e-046405910MP:0004901
MousePhenoinfertility

ANKRD31 FSIP2 KATNAL2 NLRP14 TMEM232 FMN1 CAMK4 MEIKIN RXFP2 KIAA0319L FAM227B SYT2 SPAG17 CFAP44

3.32e-0411885914MP:0001924
MousePhenoabnormal gametes

ANKRD31 FSIP2 KATNAL2 TMEM232 CAMK4 MEIKIN RXFP2 KIAA0319L SPAG17 CFAP44 HERC4

3.84e-047855911MP:0001124
MousePhenolimb grasping

EEF1B2 FBN2 CAMK4 KIAA0319L LTN1 SPAG17 EPG5

4.16e-04325597MP:0001513
MousePhenoabnormal sperm axoneme morphology

KATNAL2 TMEM232 SPAG17 CFAP44

4.29e-0484594MP:0009838
MousePhenoabnormal cilium morphology

FSIP2 KATNAL2 TMEM232 CAMK4 KIAA0319L SPAG17 CFAP44 HERC4

4.41e-04433598MP:0013202
MousePhenoabsent sperm fibrous sheath

FSIP2 SPAG17

4.82e-048592MP:0030591
MousePhenomale infertility

ANKRD31 FSIP2 KATNAL2 TMEM232 FMN1 CAMK4 MEIKIN RXFP2 KIAA0319L FAM227B SPAG17 CFAP44

4.88e-049445912MP:0001925
MousePhenoarrest of spermatogenesis

ANKRD31 CAMK4 MEIKIN RXFP2 SPAG17 HERC4

4.96e-04239596MP:0001155
MousePhenodecreased germ cell number

ANKRD31 FSIP2 KATNAL2 TMEM232 CAMK4 MEIKIN RXFP2 KIAA0319L SPAG17 CFAP44

5.44e-046875910MP:0002209
MousePhenoabnormal sperm physiology

ANKRD31 FSIP2 KATNAL2 TMEM232 KIAA0319L SPAG17 CFAP44 HERC4

5.44e-04447598MP:0004543
MousePhenoabnormal male germ cell morphology

ANKRD31 FSIP2 KATNAL2 TMEM232 CAMK4 MEIKIN RXFP2 KIAA0319L SPAG17 CFAP44 HERC4

8.17e-048595911MP:0006362
DomainSynaptotagmin

SYT5 SYT2 SYT7

5.26e-0520693IPR001565
DomainRNA_pol_II_trans_fac_SIII_A

ELOA ELOA2

1.34e-045692IPR010684
DomainElongin_A

ELOA ELOA2

1.34e-045692PF06881
DomainFERM_N

FRMD4A FERMT2 EPB41L1

2.43e-0433693PF09379
DomainFERM_N

FRMD4A FERMT2 EPB41L1

2.43e-0433693IPR018979
DomainPH

APPL2 DOCK11 TEX2 FGD5 FERMT2 TIAM2

5.63e-04278696SM00233
DomainPH_domain

APPL2 DOCK11 TEX2 FGD5 FERMT2 TIAM2

5.85e-04280696IPR001849
Domain-

FRMD4A APPL2 DOCK11 FGD5 FERMT2 EPB41L1 TIAM2

5.90e-043916972.30.29.30
DomainTFIIS/CRSP70_N_sub

ELOA ELOA2

5.94e-0410692IPR003617
DomainTFS2N

ELOA ELOA2

5.94e-0410692SM00509
DomainFERM_M

FRMD4A FERMT2 EPB41L1

6.54e-0446693PF00373
Domain-

FRMD4A FERMT2 EPB41L1

7.87e-04496931.20.80.10
DomainFERM_central

FRMD4A FERMT2 EPB41L1

7.87e-0449693IPR019748
DomainFERM_domain

FRMD4A FERMT2 EPB41L1

7.87e-0449693IPR000299
DomainFERM_1

FRMD4A FERMT2 EPB41L1

8.35e-0450693PS00660
DomainFERM_2

FRMD4A FERMT2 EPB41L1

8.35e-0450693PS00661
DomainFERM_3

FRMD4A FERMT2 EPB41L1

8.35e-0450693PS50057
DomainBand_41_domain

FRMD4A FERMT2 EPB41L1

8.35e-0450693IPR019749
DomainB41

FRMD4A FERMT2 EPB41L1

8.35e-0450693SM00295
DomainFERM/acyl-CoA-bd_prot_3-hlx

FRMD4A FERMT2 EPB41L1

8.35e-0450693IPR014352
DomainPH_dom-like

FRMD4A APPL2 DOCK11 FGD5 FERMT2 EPB41L1 TIAM2

9.76e-04426697IPR011993
Domain-

ELOA ELOA2

1.02e-03136921.20.930.10
DomainTFIIS_N

ELOA ELOA2

1.02e-0313692PS51319
DomainMed26

ELOA ELOA2

1.02e-0313692PF08711
DomainTFIIS_N

ELOA ELOA2

1.19e-0314692IPR017923
DomainPH

APPL2 DOCK11 FGD5 FERMT2 TIAM2

1.58e-03229695PF00169
DomainEz/rad/moesin-like

FRMD4A EPB41L1

2.70e-0321692IPR000798
DomainFERM_CS

FRMD4A EPB41L1

3.52e-0324692IPR019747
DomainPH_DOMAIN

APPL2 DOCK11 FGD5 FERMT2 TIAM2

3.70e-03279695PS50003
DomainFERM_C

FRMD4A EPB41L1

4.13e-0326692PF09380
DomainFERM_C

FRMD4A EPB41L1

4.45e-0327692SM01196
DomainFERM_PH-like_C

FRMD4A EPB41L1

4.45e-0327692IPR018980
DomainEF-hand_8

MICU3 RYR2

6.99e-0334692PF13833
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

NRXN2 PPFIBP1 SLITRK4 SYT2 SYT7 EPB41L1

9.45e-0787546M27617
PathwayREACTOME_NEUREXINS_AND_NEUROLIGINS

NRXN2 SYT2 SYT7 EPB41L1

6.09e-0556544M27616
PathwayWP_HIPPOCAMPAL_SYNAPTOGENESIS_AND_NEUROGENESIS

NRXN2 CAMK4 SYT2

1.46e-0427543M45550
Pubmed

Synaptotagmin-mediated vesicle fusion regulates cell migration.

SYT5 SYT2 SYT7

3.12e-08470320473299
Pubmed

Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells.

SYT5 SYT2 SYT7

1.55e-07670312860971
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

EEF1B2 KATNAL2 REXO4 APPL2 CTCF PPFIBP1 NOA1 BMS1 LTN1 EHMT1 HEATR1 DHX29 SYT7 EDRF1 EPB41L1

2.33e-071497701531527615
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

PRUNE1 ELOA EEF1B2 CTCF CAMK4 MCM4 BOD1L1 HEATR1 FERMT2 DHX29 HERC4 TOP2B

3.34e-07934701233916271
Pubmed

SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.

SYT5 SYT2 SYT7

1.27e-061170310734137
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

STK10 FRMD4A PPFIBP1 SLITRK4 KIAA0319L FERMT2 SYT7 EPB41L1 PACSIN2

2.11e-0656970930639242
Pubmed

Alternative splicing of synaptotagmins involving transmembrane exon skipping.

SYT5 SYT7

3.99e-06270210556508
Pubmed

Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders.

CTCF TOP2B

3.99e-06270227582050
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

PRUNE1 APPL2 UBR4 BOD1L1 HEATR1 FERMT2 DHX29 EPB41L1

7.25e-0649870836634849
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

TEX2 PPFIBP1 UBR4 BMS1 EHMT1 PDZD8 HEATR1 FERMT2 DHX29 EDRF1 TOP2B EPB41L1 PACSIN2

7.39e-061487701333957083
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

TEX2 FMN1 RXFP2 LTN1 BOD1L1 HEATR1 FERMT2 HERC4 PACSIN2 TIAM2 EHD3

1.03e-051084701111544199
Pubmed

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.

STK10 FMN1 PPFIBP1 FERMT2 EPB41L1 PACSIN2 EHD3

1.11e-0537770738117590
Pubmed

Association between KIAA0319L, PXK and JAZF1 gene polymorphisms and unexplained recurrent pregnancy loss in Chinese Han couples.

KIAA0319L PXK

1.20e-05370225596907
Pubmed

Synaptotagmin-7-Mediated Asynchronous Release Boosts High-Fidelity Synchronous Transmission at a Central Synapse.

SYT2 SYT7

1.20e-05370228521135
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

PRUNE1 PPFIBP1 PDZD8 MCM4 BOD1L1 FERMT2 DHX29 EPB41L1 PACSIN2

1.23e-0570870939231216
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

PRUNE1 FRMD4A EEF1B2 MICU3 TEX2 CAMK4 UBR4 FERMT2 DHX29 EPB41L1 RYR2

1.63e-051139701136417873
Pubmed

Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II.

ELOA ELOA2

2.39e-0547027660129
Pubmed

Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis.

ELOA ELOA2

2.39e-05470210692460
Pubmed

Transcriptional properties of mammalian elongin A and its role in stress response.

ELOA ELOA2

2.39e-05470223828199
Pubmed

Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo.

ELOA ELOA2

2.39e-05470233334895
Pubmed

Mammalian elongin A is not essential for cell viability but is required for proper cell cycle progression with limited alteration of gene expression.

ELOA ELOA2

2.39e-05470212604609
Pubmed

Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation.

ELOA ELOA2

2.39e-05470223122963
Pubmed

Structural organization and chromosome location of the mouse elongin A gene (Tceb3).

ELOA ELOA2

2.39e-05470210575222
Pubmed

Functional characterization of a mammalian transcription factor, Elongin A.

ELOA ELOA2

2.39e-05470217112477
Pubmed

Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription.

ELOA ELOA2

2.39e-05470229153392
Pubmed

Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.

SYT2 SYT7

2.39e-05470220926654
Pubmed

A Synaptotagmin Isoform Switch during the Development of an Identified CNS Synapse.

SYT5 SYT2

2.39e-05470227210552
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

EEF1B2 REXO4 GUCY1B2 UBR4 BMS1 EHMT1 MCM4 BOD1L1 FGD5 HEATR1 DHX29 TOP2B

2.52e-051425701230948266
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

ELOA KATNAL2 REXO4 CTCF BMS1 PDZD8 MCM4 BOD1L1 HEATR1 TOP2B

2.80e-05989701036424410
Pubmed

The mouse Brachyury gene and mesoderm formation.

SYT5 SYT2

3.98e-0557022132728
Pubmed

Synaptotagmins 3 and 7 mediate the majority of asynchronous release from synapses in the cerebellum and hippocampus.

SYT5 SYT7

3.98e-05570239116209
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

REXO4 CTCF BMS1 HEATR1 DHX29 TOP2B

5.67e-0533270625693804
Pubmed

Phospholipid composition dependence of Ca2+-dependent phospholipid binding to the C2A domain of synaptotagmin IV.

SYT5 SYT2

5.96e-0567028626542
Pubmed

Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary.

CTCF TOP2B

5.96e-05670219450526
Pubmed

EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells.

ELOA ELOA2

8.33e-05770227863225
Pubmed

The N-terminal cysteine is a dual sensor of oxygen and oxidative stress.

UBR4 RGS4

8.33e-05770234893540
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

EEF1B2 UBR4 LTN1 EHMT1 MCM4 HEATR1 DHX29 TOP2B

8.47e-0570470829955894
Pubmed

Evolution of the mouse t haplotype: recent and worldwide introgression to Mus musculus.

SYT5 SYT2

1.11e-0487021495973
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

REXO4 CDKL2 DOCK11 UBR4 BMS1 BOD1L1 FAM227B CFAP44

1.15e-0473670829676528
Pubmed

Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X.

SYT5 SYT7

1.42e-04970210531343
Pubmed

Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin.

SYT5 SYT2

1.42e-0497028901523
Pubmed

Distinct developmental expression of synaptotagmin I and IX in the mouse brain.

SYT5 SYT2

1.42e-04970216407767
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

PRUNE1 EEF1B2 FBN2 UBR4 BMS1 LTN1 MCM4 HEATR1 DHX29

1.44e-0497470928675297
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

REXO4 CAMK4 PPFIBP1 KIAA0319L BMS1 EHMT1 FERMT2 RYR2

1.67e-0477770835844135
Pubmed

Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion.

SYT5 SYT2

1.78e-04107029914469
Pubmed

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.

RIN3 NUF2

2.17e-041170224621683
Pubmed

Endocardiogenesis in embryoid bodies: novel markers identified by gene expression profiling.

FGD5 PCGF5

2.17e-041170217462595
Pubmed

Secreted TARSH regulates olfactory mitral cell dendritic complexity.

SLITRK4 RGS4

2.60e-041270219302145
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

FRMD4A UBR4 BOD1L1 ZMYM6

2.63e-0415370410718198
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

ELOA REXO4 BMS1 BOD1L1 TOP2B

2.71e-0428370530585729
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

EEF1B2 KATNAL2 REXO4 CTCF BMS1 EHMT1 HEATR1 TOP2B

2.98e-0484770835850772
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

ELOA PPFIBP1 ACTR10 MCM4 NUF2 HEATR1 FERMT2 PCGF5 EDRF1 EHD3

3.02e-041321701027173435
Pubmed

Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.

ELOA ELOA2

3.07e-041370219037258
Pubmed

Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.

HEATR1 RYR2

3.58e-041470211472062
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

EEF1B2 REXO4 UBR4 BMS1 LTN1 MCM4 HEATR1 FERMT2 DHX29 TOP2B

3.64e-041353701029467282
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

DOCK11 TEX2 FMN1 UBR4 DHX29 TOP2B

3.94e-0447570631040226
Pubmed

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.

CTCF EHMT1 CHRAC1

5.13e-047770319505873
Pubmed

Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A.

ELOA ELOA2

5.33e-041770217170753
Pubmed

Genome-wide meta-analysis identifies new susceptibility loci for migraine.

STK10 FRMD4A FBN2

5.33e-047870323793025
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

APPL2 TEX2 PPFIBP1 ACTR10 KIAA0319L PDZD8

5.38e-0450470634432599
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

EEF1B2 APPL2 ACTR10 UBR4 MCM4 CHRAC1 FERMT2 HERC4 EPB41L1 PACSIN2

6.42e-041455701022863883
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

ELOA EEF1B2 REXO4 CTCF MCM4 BOD1L1 HEATR1 TOP2B

6.54e-0495470836373674
Pubmed

Genetic mapping of five mouse genes encoding synaptotagmins.

CAMK4 SYT2

6.68e-04197028747928
Pubmed

Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses.

ELOA ELOA2

6.68e-041970216705022
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

NRXN2 TEX2 BMS1 EHMT1 HERC4 TIAM2

6.93e-0452970614621295
Pubmed

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

EEF1B2 REXO4 CTCF BMS1 MCM4

7.02e-0434970525665578
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

TEX2 CAMK4 EHMT1 MCM4 FGD5 HEATR1 TIAM2

8.03e-0475470735906200
Pubmed

A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.

ELOA ELOA2

8.18e-042170219345177
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

UBR4 LTN1 HERC4

9.47e-049570329643511
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

ELOA EEF1B2 CTCF UBR4 EHMT1 MCM4 BOD1L1 TOP2B

9.70e-04101470832416067
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

FMN1 PPFIBP1 DHX29 SYT7 EPB41L1 PACSIN2

9.74e-0456570625468996
Pubmed

A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.

KIAA0319L PXK

1.36e-032770223740937
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

FSIP2 ELOA REXO4 EHMT1 BOD1L1 TOP2B

1.42e-0360870636089195
Pubmed

Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.

PACSIN2 EHD3

1.46e-032870226884322
Pubmed

Phosphoproteomic analysis of the developing mouse brain.

FRMD4A EEF1B2 CHRAC1 EPB41L1

1.55e-0324670415345747
Pubmed

Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.

PDZD8 ZMYM6

1.57e-032970221834987
Pubmed

Network organization of the huntingtin proteomic interactome in mammalian brain.

CAMK4 SYT5 SYT2 RGS4 PACSIN2 EHD3

1.58e-0362170622794259
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

STK10 APPL2 PPFIBP1 FERMT2 EPB41L1

1.61e-0342170536976175
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

FSIP2 DOCK11 TEX2 PPFIBP1 BOD1L1 EDRF1 EPB41L1

1.72e-0386170736931259
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

ELOA2 GUCY1B2 UBR4 EHMT1 FGD5 RYR2

1.81e-0363870631182584
Pubmed

A directed protein interaction network for investigating intracellular signal transduction.

RIN3 NRXN2 NOA1 UBR4 SYT5 AIDA EDRF1 TIAM2

1.86e-03112470821900206
Pubmed

NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.

NLRP14 TOP2B

1.90e-033270238060382
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

DOCK11 MCM4 DHX29 TOP2B RPAP2

1.95e-0344070534244565
InteractionRPL13A interactions

EEF1B2 RIN3 REXO4 DOCK11 CTCF UBR4 BMS1 PDZD8 BOD1L1 DHX29 HERC4 RYR2

6.94e-075916912int:RPL13A
GeneFamilySynaptotagmins

SYT5 SYT2 SYT7

7.20e-0617413765
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

APPL2 DOCK11 FGD5 FERMT2 TIAM2

9.82e-05206415682
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

FRMD4A FERMT2 EPB41L1

1.97e-04504131293
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

FGD5 TIAM2

9.82e-0366412722
GeneFamilyEF-hand domain containing

MICU3 RYR2 EHD3

1.33e-02219413863
GeneFamilyRing finger proteins

DTX4 LTN1 PCGF5

2.43e-0227541358
CoexpressionLASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN

ELOA UBR4 KIAA0319L PDZD8 BOD1L1 FGD5 SYT7 HERC4 EDRF1 TOP2B ZMYM6

9.10e-068077011M14594
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HNBGABA

FRMD4A MICU3 NRXN2 CDKL2 ASIC2 SLITRK4 SYT7 PXK EPB41L1 RYR2

1.68e-057037010M39070
CoexpressionVERNELL_RETINOBLASTOMA_PATHWAY_DN

APPL2 PPFIBP1 EHD3

3.11e-0523703M12456
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

FSIP2 MICU3 NRXN2 CDKL2 ASIC2 PPFIBP1 SLITRK4 BOD1L1 SPAG17 PXK EPB41L1 RYR2

3.32e-0511067012M39071
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ASIC2 CAMK4 PPFIBP1 SYT7 RGS4 CDH12 RYR2

2.05e-08190707d594da827e3c16644952b9589cc12b947ce36279
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ANKRD31 KATNAL2 SLC9A4 SYT5 SPAG17 CFAP44

7.19e-0719970615f7814b7074170eee7ccacaa670b1d128fc68bb
ToppCellLPS_IL1RA-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

KATNAL2 SLC9A4 TMEM232 SYT5 SPAG17 CFAP44

7.41e-072007064992dbf0514d674017315dbd20d91dfec0c608e9
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KATNAL2 SLC9A4 SYT5 SPAG17 CFAP44

4.45e-061547059ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KATNAL2 SLC9A4 SYT5 SPAG17 CFAP44

4.45e-0615470558072ce422d09f2de602580325eaac6c4ec6c136
ToppCellCOVID-CD8-memory_CD4|COVID / Condition, Cell_class and T cell subcluster

CDKL2 PPFIBP1 FAM227B NUF2 TIAM2

5.70e-0616270522b2a32217d357146c117e618813d451510a1801
ToppCelldroplet-Lung-nan-18m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM232 SYT5 FAM227B SPAG17 CFAP44

1.11e-05186705740fd06bcd3b24e6ff2ecf8080f378afc3e95084
ToppCelldroplet-Lung-nan-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM232 SYT5 FAM227B SPAG17 CFAP44

1.11e-051867055ab43a298d23238b34e898d11decf0ad81d1b14e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 CDKL2 DOCK11 PPFIBP1 EPB41L1

1.17e-0518870563a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MICU3 NRXN2 CAMK4 SYT2 SYT7

1.20e-05189705f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ASIC2 FMN1 PPFIBP1 SYT7 RGS4

1.20e-05189705c3df0e3c50af8f1cfb4d790e668bd7f42b276992
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ASIC2 CAMK4 SYT7 CDH12 RYR2

1.23e-0519070549e09cdb843b3d889a06a811aa5affae68b25a75
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ASIC2 CAMK4 SYT7 RGS4 RYR2

1.30e-051927055c7e8b80b44d9ce55c797cdf8267ac5382e26cac
ToppCellCTRL-Myeloid-Alveolar_Macrophage|Myeloid / Disease state, Lineage and Cell class

FRMD4A DOCK11 DTX4 FGD5 EPB41L1

1.33e-0519370580871d963c23a6befe58e5e60b7f7d1a1b227ce2
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MICU3 NRXN2 CAMK4 SYT2 SYT7

1.33e-051937055fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCellRA-08._Macrophage|RA / Chamber and Cluster_Paper

STK10 FRMD4A RIN3 DOCK11 FMN1

1.36e-05194705ac26e5c71d5069622de72fa25a9c920887ac2c19
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CAMK4 SYT7 RGS4 CDH12 RYR2

1.40e-051957052e1df01bf6e4e98e6cd9fb50926e34c5077b8666
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STK10 RIN3 DOCK11 FMN1 CAMK4

1.47e-05197705c9b1f2ee7eb31a66af331c5aae29e1bbb5186f5a
ToppCellbackground-Kupffer_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

STK10 FRMD4A RIN3 DOCK11 FMN1

1.47e-051977058b45c7ecc18d188abc8c172d9bf881c95617a46a
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

KATNAL2 SLC9A4 TMEM232 SPAG17 CFAP44

1.58e-0520070596701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCellTCGA-Peripheral_Nervous_System|World / Sample_Type by Project: Shred V9

CAMK4 SYT5 SYT2 RGS4

7.83e-051447043bbadb4b07ffb461d5400a5d69ad3b259f74041e
ToppCellCOVID-19-kidney-Technical/muscle|kidney / Disease (COVID-19 only), tissue and cell type

FBN2 ASIC2 CDH12 RYR2

8.71e-051487040dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCellControl-B_intermediate-6|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

STK10 RIN3 PXK EHD3

8.71e-05148704662c057030effc9eb61216e81d3967e6983c244f
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8|TCGA-Bladder / Sample_Type by Project: Shred V9

SLC9A4 DTX4 CFAP44 TOP2B

9.17e-051507041aa9320d97ff10994ea024751790524fe133aba9
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KATNAL2 SLC9A4 SPAG17 CFAP44

1.04e-041557045f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KATNAL2 SLC9A4 SPAG17 CFAP44

1.04e-041557040944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

TMEM232 CAMK4 SYT5 TIAM2

1.26e-04163704218b9ba099cb27aa91c6b73bf89b44895f5dddc3
ToppCelldroplet-Limb_Muscle-nan-3m-Myeloid-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK10 FRMD4A EDRF1 TIAM2

1.36e-041667040a7992bc673fca546636563ec3fc17a4298ab6b1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FSIP2 CDKL2 DOCK11 PPFIBP1

1.49e-041707045d5f208682be21ed58320f5fc083a7898f8712da
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYT5 SYT2 SYT7 RGS4

1.49e-0417070402f0be0aab8ba2d35a83238609352ef3677511c9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 DOCK11 PPFIBP1 SPAG17

1.66e-04175704284fdc7a9d303636a637041846850d19d114861a
ToppCell3'-Adult-Appendix-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FSIP2 FRMD4A MICU3 MCM4

1.70e-0417670430adf8f1638c6244586f8101c2590bb964dfae00
ToppCell3'-Adult-Appendix-Epithelial-mature_enterocytic-Colonocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FSIP2 FRMD4A MICU3 MCM4

1.70e-0417670423fa02d4c39e0b8faa1658116d50b6233a952ccc
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 CDKL2 DOCK11 PPFIBP1

1.70e-04176704327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KATNAL2 CDKL2 RXFP2 SPAG17

1.70e-04176704d6d7e4e937d49a5c0d16322c8dd3bf9e97eb8732
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KATNAL2 CDKL2 RXFP2 SPAG17

1.70e-04176704c03d80df2550c0d2b0452326480d6bf21d20fdd2
ToppCell367C-Myeloid-Dendritic-cDC_proliferating_1|367C / Donor, Lineage, Cell class and subclass (all cells)

MEIKIN MCM4 NUF2 SYT2

1.73e-04177704ba701d3c90722d8bff70d0fa651899305cdad257
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

NRXN2 MEIKIN SYT7 EPB41L1

1.77e-04178704edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMK4 SYT2 CDH12 RYR2

1.85e-04180704f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RXFP2 SPAG17 CFAP44 RGS4

1.89e-04181704c1b1e62440805800a3a600b1ddd79be1c9762598
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A FBN2 DOCK11 SYT2

1.89e-041817045f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2|TCGA-Skin / Sample_Type by Project: Shred V9

CDKL2 TEX2 FMN1 EPG5

1.89e-041817049d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A FBN2 DOCK11 SYT2

1.89e-04181704c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMK4 BOD1L1 TOP2B EHD3

1.93e-04182704e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMK4 BOD1L1 TOP2B EHD3

1.93e-041827041710eab3037a87609d21838be2d2d29c3bc36651
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A CDKL2 DOCK11 PPFIBP1

1.97e-04183704738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FRMD4A FBN2 DOCK11 RYR2

1.97e-041837048a799807fbf24456a9811e0c64068187940a2f71
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-ependymal_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM232 NUF2 SPAG17 CFAP44

1.97e-041837046ca7c2d7c56e0f1b9038ba677b4c1c3dfd63bfce
ToppCelldroplet-Lung-LUNG-30m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM232 ASIC2 SPAG17 CFAP44

1.97e-041837043991830726d05cf19606d540de04093985b7bdeb
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-Ependyma|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM232 NUF2 SPAG17 CFAP44

1.97e-0418370418040d0653286071df959513c63d94b555a5d00a
ToppCelldroplet-Lung-LUNG-30m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM232 ASIC2 SPAG17 CFAP44

1.97e-04183704cc844f54c7564bf432b179ca63bc7c4b9b8cfdd9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 CDKL2 DOCK11 PPFIBP1

1.97e-0418370492fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PPFIBP1 SYT5 RGS4 CDH12

2.01e-04184704ca35a3d2b536c8b2bf5c4d635605e5a3ae94a428
ToppCellPosterior_cortex-Neuronal-Excitatory|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CAMK4 SYT5 TIAM2 RYR2

2.01e-0418470425ccf08a8a26d7e7827b6357f33a53aaf423577d
ToppCellControl-Myeloid-Macrophage_Alveolar|World / Disease state, Lineage and Cell class

FRMD4A DOCK11 FGD5 EPB41L1

2.05e-0418570485cb81759589a26d83676cffbf2bc37399683c10
ToppCellfacs-Brain_Non-Myeloid-Cerebellum|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMK4 SYT7 CDH12 RYR2

2.05e-04185704c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCellP28-Epithelial-airway_epithelial_cell-club_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TMEM232 SYT5 SPAG17 CFAP44

2.10e-04186704a26811481668fa25c48a064a56c198685693ad8d
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 ASIC2 SYT5 RGS4

2.10e-041867042f103ce2427f9cf2c1fafb6bd6045c5863a47549
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MICU3 NRXN2 CAMK4 SYT2

2.10e-04186704d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CAMK4 RGS4 TIAM2 RYR2

2.10e-0418670456c139e679d640ea901ead657a8e8887e0fca098
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_EGR3|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PPFIBP1 SYT5 RGS4 CDH12

2.10e-0418670477b09af860183606a1775eba921e2071e4a7dd4e
ToppCellP28-Epithelial-airway_epithelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TMEM232 SYT5 SPAG17 CFAP44

2.10e-04186704df80f101954b8ec6ccdb03e702de22e70b65181f
ToppCell18-Distal-Epithelial-Multiciliated_precursor|Distal / Age, Tissue, Lineage and Cell class

KATNAL2 TMEM232 SYT5 SPAG17

2.10e-0418670458ab1360a1730655a5939295ba05997ac4a2d14e
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FMN1 PPFIBP1 SYT7 RGS4

2.14e-04187704f18628ffc7ff7c762b8339ba8822cf0c3157f469
ToppCellfacs-Lung-EPCAM-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KATNAL2 TMEM232 SPAG17 CFAP44

2.14e-04187704051b8c07d7489ce7576f6c57ce7008767ef76869
ToppCellfacs-Lung-EPCAM-18m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KATNAL2 TMEM232 SPAG17 CFAP44

2.14e-04187704888856cde7a69ea2f14d590597e25b1af6383c51
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM232 SYT5 SPAG17 CFAP44

2.14e-041877041bba994aaaa9825b54aaeaff3829850267bc4602
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CDKL2 DOCK11 PPFIBP1 EPB41L1

2.14e-04187704c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM232 SYT5 SPAG17 CFAP44

2.14e-04187704d6ac351e7aeba98851d308c14ac395044fe4fbbb
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A FBN2 DOCK11 SYT2

2.18e-04188704b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PPFIBP1 SYT7 CDH12 RYR2

2.18e-0418870450c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A FBN2 DOCK11 SYT2

2.18e-04188704874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCelldroplet-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM232 SYT5 SPAG17 CFAP44

2.18e-041887040eca3dc93724e23b71e687fc24fa9f1e89bdef6a
ToppCelldroplet-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM232 SYT5 SPAG17 CFAP44

2.18e-041887049ce3e1fffce87ad19812ecbf9b7f9935a975d676
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM232 SYT5 SPAG17 CFAP44

2.23e-0418970428c750ac56e3861fe7280e32839a4d8ce8bd8692
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT5 SYT2 RGS4 EPB41L1

2.23e-04189704de51fbd6fdb24fc4549393cf41a020005444b2aa
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM232 SYT5 SPAG17 CFAP44

2.23e-04189704efee01edd171bf569267b672fab05c421de6c92d
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM232 SYT5 SPAG17 CFAP44

2.23e-04189704a28e0922e10013ae79266f6a3f9305e6ee614d8b
ToppCellControl-Myeloid-Macrophage_Alveolar|Control / Disease state, Lineage and Cell class

FRMD4A DOCK11 FGD5 EPB41L1

2.23e-04189704937e876122bc4b94372a4104e9c1a9068c232018
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ASIC2 SYT7 CDH12 RYR2

2.23e-04189704a75226616340045b581d08429d2e123e041dee55
ToppCelldroplet-Lung-18m-Epithelial-airway_epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM232 SYT5 SPAG17 CFAP44

2.23e-04189704fe958fdf9963c2dfe270f67f0da36b3264d0017c
ToppCellCOVID-19-Heart-Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

FRMD4A RIN3 DOCK11 FMN1

2.23e-041897042586f4088721c5debec86c2b211b739fd33713eb
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT5 SYT2 RGS4 EPB41L1

2.27e-041907041d8e169d2448a34180c415843bb49aa45ed540c5
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM232 SYT5 SPAG17 CFAP44

2.27e-041907049ffd18ef358f8e32c610ab6420f479067c8ba44b
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM232 SYT5 SPAG17 CFAP44

2.27e-041907043ef39d61c98de4e5df946b995847aa65eba6a4b6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CDKL2 ASIC2 SPAG17 EPB41L1

2.27e-041907043fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCellIPF-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

FRMD4A DOCK11 FGD5 EPB41L1

2.27e-041907042592765016f291565697265800a232b2edef3792
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM232 SYT5 SPAG17 CFAP44

2.32e-04191704649fcb62ad15de2f83e61591e43923a717664ae7
ToppCellP07-Mesenchymal-developing_mesenchymal_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NUF2 FERMT2 RGS4 EHD3

2.32e-04191704ddbc5f97f2aef19be4ad93db4139876c939b848e
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM232 SYT5 SPAG17 CFAP44

2.32e-041917049621e22e14ea069f22713947c9faa2d882abe5fe
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

FRMD4A DTX4 FGD5 EPB41L1

2.32e-041917042b10a73c5d80e83d67a7121fb004a1aa86a537ef
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FRMD4A DTX4 FGD5 EPB41L1

2.32e-0419170402e1ae144da7274171e055356d10e8d175c5347f
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KATNAL2 CDKL2 SPAG17 CFAP44

2.32e-04191704e8d56e9f43943e9cc4dce83f2c234f19c2dd487d
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KATNAL2 CDKL2 SPAG17 CFAP44

2.32e-0419170452e8d7dfaf1ebb6df8bf3a1f4546af59faa67657
ToppCellSevere_COVID-19-Myeloid-TRAM3|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

FRMD4A DTX4 FGD5 EPB41L1

2.32e-0419170405867b96199a46a415848409130697c810d18937
ToppCellBAL-Severe-Myeloid-TRAM|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

FRMD4A DTX4 FGD5 EPB41L1

2.32e-041917044c4f50a502e3f6768a89df686fa2830b83b8b33f
ToppCellControl-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

FRMD4A DOCK11 FGD5 EPB41L1

2.32e-04191704a7bb8aba9c59c037d995a77928cc7b4d5cbb82b9
ToppCellBAL-Severe-Myeloid-TRAM|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FRMD4A DTX4 FGD5 EPB41L1

2.32e-04191704de7c88bb46f794291025ef121a89fcd94dea4ffe
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM232 SYT5 SPAG17 CFAP44

2.32e-041917046a8fc9dc1a4c7115862e8f20204fa2f95e50e22f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Non-classical_Monocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STK10 RIN3 FBN2 FMN1

2.32e-0419170447a2afc4102199b4bc76bd01b2967c8016186462
Diseasecongenital myasthenic syndrome 7 (implicated_via_orthology)

SYT5 SYT2

3.22e-054692DOID:0110659 (implicated_via_orthology)
Diseaseneuromuscular junction disease (implicated_via_orthology)

SYT5 SYT2

5.36e-055692DOID:439 (implicated_via_orthology)
Diseasecongenital myasthenic syndrome (implicated_via_orthology)

SYT5 SYT2

6.33e-0416692DOID:3635 (implicated_via_orthology)
Diseaseage of onset of asthma

CTCF FAM227B RPAP2

8.52e-0479693OBA_2001001
Diseasesystemic scleroderma, systemic lupus erythematosus

KIAA0319L PXK

1.69e-0326692EFO_0000717, MONDO_0007915
DiseaseDrug habituation

FRMD4A APPL2 TIAM2

2.51e-03115693C0013170
DiseaseSubstance-Related Disorders

FRMD4A APPL2 TIAM2

2.51e-03115693C0236969
DiseaseDrug abuse

FRMD4A APPL2 TIAM2

2.51e-03115693C0013146
DiseaseDrug Use Disorders

FRMD4A APPL2 TIAM2

2.51e-03115693C0013222
DiseaseDrug Dependence

FRMD4A APPL2 TIAM2

2.51e-03115693C1510472
DiseaseSubstance Dependence

FRMD4A APPL2 TIAM2

2.51e-03115693C0038580
DiseaseSubstance Use Disorders

FRMD4A APPL2 TIAM2

2.51e-03115693C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

FRMD4A APPL2 TIAM2

2.51e-03115693C0029231
DiseasePrescription Drug Abuse

FRMD4A APPL2 TIAM2

2.51e-03115693C4316881
Diseaseocular sarcoidosis

FRMD4A FBN2 CDH12

2.57e-03116693EFO_0010723
DiseaseSubstance abuse problem

FRMD4A APPL2 TIAM2

2.57e-03116693C0740858
Diseaseage of onset of Alzheimer disease

FMN1 FERMT2

2.72e-0333692OBA_2001000
Diseaseurate measurement, bone density

FSIP2 KATNAL2 ASIC2 PPFIBP1 CDH12 TIAM2

3.26e-03619696EFO_0003923, EFO_0004531
DiseaseMalignant neoplasm of breast

EEF1B2 NLRP14 NOA1 UBR4 EHMT1 BOD1L1 FGD5 EPG5

3.52e-031074698C0006142
DiseaseIntellectual Disability

EEF1B2 NRXN2 CTCF EPB41L1 ZMYM6

3.96e-03447695C3714756
Diseaseascending aortic diameter

FBN2 FGD5 RYR2

4.36e-03140693EFO_0021787

Protein segments in the cluster

PeptideGeneStartEntry
KKTKIKLTKIFQEPL

FAM227B

411

Q96M60
SRTKTKEKKKYETPQ

EPG5

16

Q9HCE0
DYQPPAKKTKKTKKS

CTCF

196

P49711
YKKPTDFKRKKLQLL

AIDA

276

Q96BJ3
KTKTYEEDPKSKPKK

DHX29

206

Q7Z478
KGKTPEEVLKKYLQK

DTX4

386

Q9Y2E6
IKIVKKLKLTGFPYK

BMS1

1021

Q14692
LKKEYDTLSKKVKIV

CFAP44

1576

Q96MT7
LVEKPKYKKALGTKT

ACTR10

326

Q9NZ32
VKIPSKTSAKYLEKK

ASIC2

376

Q16515
KKPLSETYEKKNKVK

FMN1

1031

Q68DA7
KLILKVKKQLAPYLK

LTN1

131

O94822
TIKKALNYSTAPKKK

ANKRD31

1681

Q8N7Z5
KIGKATPKDSKYVEK

PRUNE1

186

Q86TP1
KKLILSKGKTPALKY

MCM4

806

P33991
KTEPKKLEKYLQKLS

ELOA2

21

Q8IYF1
SKAQKSPQKIAKKYK

EPB41L1

81

Q9H4G0
IKKFLSLKLKLPSSY

PCGF5

176

Q86SE9
YVLLTATAKVKPKKL

PPFIBP1

891

Q86W92
DSENIKKLLKIPYSK

EDRF1

126

Q3B7T1
KGTQKPYALKVLKKT

CAMK4

66

Q16566
PYALKVLKKTVDKKI

CAMK4

71

Q16566
KPKRKSKYKILDATD

KIAA0319L

961

Q8IZA0
DSSFLQKLKKKEYPK

FSIP2

3406

Q5CZC0
QKLKKKEYPKIETVK

FSIP2

3411

Q5CZC0
KTKIVDSPEKLKNYK

NUF2

241

Q9BZD4
VKFQKYPKIVKKSSD

KATNAL2

81

Q8IYT4
KKIIKRKHTLPNYKI

PDZD8

276

Q8NEN9
LLIESDSPDKYKKKK

FGD5

636

Q6ZNL6
LRKTKNIDYKKPLKV

HERC4

726

Q5GLZ8
YKKLLKKKPSLDDLK

HERC4

821

Q5GLZ8
PKTPSKAKKNKDKEY

NRXN2

1696

Q9P2S2
VIVKKKKYSLPKDTP

MEIKIN

351

A0A087WXM9
KTVQKYPTFKSCLKK

MICU3

511

Q86XE3
VLKTKEKYEKSLKEL

PACSIN2

201

Q9UNF0
RAKLPLAKEKYKSDK

BOD1L1

991

Q8NFC6
PKIKDYKLFKIKGSK

CDKL2

346

Q92772
PNVSKKLKKQRKTSY

FRMD4A

486

Q9P2Q2
KLLSEYKKPEKTKLQ

DOCK11

566

Q5JSL3
KLLKYLKKLSTLPIT

ELOA

51

Q14241
KYSRLPKKKENEKVK

APPL2

146

Q8NEU8
KLKKPLDFETKKAYT

CDH12

331

P55289
VLLPAIKKTYKQIEK

HEATR1

1821

Q9H583
EITSIPLYKKKELKK

FBN2

2871

P35556
PLYKKKELKKLEESN

FBN2

2876

P35556
YESKKAKKPALVAKS

EEF1B2

126

P24534
ADYIKVFKPKKLTLK

FERMT2

376

Q96AC1
LMKPYKLLSEKEKEI

RYR2

2756

Q92736
YSLVPKKKTKVLKQR

EHMT1

296

Q9H9B1
IKKSVAYKTKKPPSL

NOA1

671

Q8NC60
KAYSPEKKISILLKT

RIN3

751

Q8TB24
KKKIRDTQKYKPFKS

REXO4

341

Q9GZR2
VFLLPDKKKKYETKV

SYT2

181

Q8N9I0
RKKKTTIKKNTLNPY

SYT5

291

O00445
KIYLLPDKKHKLETK

SYT7

176

O43581
YPEKQPDKKSKKSLI

SLITRK4

781

Q8IW52
KKCSSVKYSKIKGIP

TOP2B

446

Q02880
EEYKKIKSPSKLSPK

RGS4

96

P49798
IKSPSKLSPKAKKIY

RGS4

101

P49798
EKKKTETLLYAMLPK

GUCY1B2

356

O75343
KNLPKSSIVSLYKKL

SLC9A4

536

Q6AI14
SLPDKVFIKYTKLKK

RXFP2

151

Q8WXD0
VSEGLKKLYKSKLLP

EHD3

21

Q9NZN3
RSLKKKSPYKEKSKE

SPAG17

981

Q6Q759
ADILPKKILASKYLK

CHRAC1

91

Q9NRG0
LVYKENCKLKKKLPS

TIAM2

1361

Q8IVF5
IVPKQKYKISTKTNK

RPAP2

111

Q8IXW5
LPLKKPSIKKDQTKY

TMEM232

536

C9JQI7
SIKDPKLYKKTLKRT

STK10

516

O94804
KGTLKDLIYKAKPKD

PXK

231

Q7Z7A4
LKKKPVVTIYTKSIS

ZMYM6

176

O95789
SKKIQMKLSKIKLPY

TEX2

846

Q8IWB9
SLKTPQTEKKLKEYS

UBR4

3476

Q5T4S7
DRLKTLTKIKPYKCK

ZNF560

701

Q96MR9
IVKLYKVLKSPKCKL

NLRP14

1031

Q86W24