Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Anhidrosis	NGF ALPK1 RYR1	3.12e-05	38	9	3	HP:0000970
Domain	SPRY	SPSB3 RYR1	6.00e-03	87	25	2	SM00449
Domain	SPRY	SPSB3 RYR1	6.97e-03	94	25	2	PF00622
Domain	SPRY_dom	SPSB3 RYR1	6.97e-03	94	25	2	IPR003877
Domain	B30.2/SPRY	SPSB3 RYR1	7.12e-03	95	25	2	IPR001870
Domain	B302_SPRY	SPSB3 RYR1	7.12e-03	95	25	2	PS50188
Pubmed	Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6.	NGF RYR1	8.05e-06	6	26	2	9480761
Pubmed	Attempts to understand the mechanisms of mitochondrial diseases: The reverse genetics of mouse models for mitochondrial disease.	NDUFS4 POLG	8.05e-06	6	26	2	33358867
Pubmed	Establishment of neurovascular congruency in the mouse whisker system by an independent patterning mechanism.	NGF PLXND1	2.94e-05	11	26	2	24139045
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	TRMT1L DHX29 MAGIX TRIM56 SPTBN2	2.97e-05	496	26	5	31343991
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	SMU1 INCENP DHX29 TRIM56	1.03e-04	332	26	4	25693804
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	TRMT1L FRAT2 RYR1 TRIM56 SPTBN2	1.86e-04	732	26	5	34732716
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	SMU1 EPPK1 TRMT1L INCENP TRIM56 SPTBN2	2.72e-04	1257	26	6	36526897
Pubmed	A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.	SMU1 EPPK1	2.97e-04	34	26	2	12577067
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	SMU1 TRMT1L DHX29 TRIM56	4.05e-04	475	26	4	31040226
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	SMU1 TRMT1L DHX29	5.45e-04	215	26	3	35973513
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SMU1 TRMT1L DHX29 NDUFS4 TRIM56 ZFP91	6.90e-04	1497	26	6	31527615
Interaction	DNASE1L2 interactions	SLC19A2 CCT6B TRMT1L	3.81e-06	25	25	3	int:DNASE1L2
Cytoband	Ensembl 112 genes in cytogenetic band chr5q11	DHX29 NDUFS4	1.33e-03	95	26	2	chr5q11
CoexpressionAtlas	ratio_EmbryoidBody-blastocyst_vs_EmbryoidBody-fibro_top-relative-expression-ranked_1000_k-means-cluster#1	YRDC EPPK1 ALPK1 TRMT1L MAGIX TRIM56 ZFP91	1.07e-07	346	25	7	ratio_EB-blastocyst_vs_EB-fibro_1000_K1
CoexpressionAtlas	ratio_EmbryoidBody-blastocyst_vs_EmbryoidBody-fibro_top-relative-expression-ranked_1000	YRDC EPPK1 ALPK1 TRMT1L MAGIX TRIM56 ZFP91	1.03e-04	983	25	7	PCBC_ratio_EB-blastocyst_vs_EB-fibro_1000
Drug	riluzole	NGF NRG2 RYR1 ZFP91	4.32e-05	174	26	4	CID000005070
Drug	3-hydroxy-3-methylglutaric acid	NGF PTGER1 ZFP91	5.02e-05	63	26	3	CID000001662
Drug	Astemizole [68844-77-9]; Down 200; 8.8uM; PC3; HT_HG-U133A	NRG2 PLXND1 INCENP POLG	6.21e-05	191	26	4	4471_DN
Drug	Gemfibrozil [25812-30-0]; Up 200; 16uM; PC3; HT_HG-U133A	NGF CCT6B ALPK1 POLG	6.73e-05	195	26	4	2113_UP
Drug	Deoxycorticosterone [64-85-7]; Down 200; 12.2uM; MCF7; HT_HG-U133A	TRMT1L FRAT2 SPSB3 POLG	6.73e-05	195	26	4	5357_DN
Drug	Tetracaone hydrochloride [136-47-0]; Down 200; 13.2uM; MCF7; HT_HG-U133A	ALPK1 INCENP POLG RYR1	6.86e-05	196	26	4	2888_DN
Drug	Hexylcaine hydrochloride [532-76-3]; Up 200; 13.4uM; PC3; HT_HG-U133A	CCT6B PLXND1 ALPK1 SPTBN2	7.00e-05	197	26	4	5768_UP
Drug	Ifenprodil tartrate [23210-58-4]; Down 200; 8.4uM; PC3; HT_HG-U133A	CCT6B EPPK1 POLG SPTBN2	7.00e-05	197	26	4	5044_DN
Drug	Aztreonam [78110-38-0]; Up 200; 9.2uM; PC3; HT_HG-U133A	NGF NRG2 PLXND1 ALPK1	7.14e-05	198	26	4	2118_UP
Drug	Ethionamide [536-33-4]; Down 200; 24uM; PC3; HT_HG-U133A	CCT6B PLXND1 INCENP SPTBN2	7.28e-05	199	26	4	4593_DN
Disease	Autosomal Dominant Parkinsonism	NGF POLG	2.37e-04	28	24	2	C0752098
Disease	Autosomal Dominant Juvenile Parkinson Disease	NGF POLG	2.37e-04	28	24	2	C0752097
Disease	PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE	NGF POLG	2.37e-04	28	24	2	C1868675
Disease	Parkinsonism, Experimental	NGF POLG	2.37e-04	28	24	2	C0752101
Disease	Autosomal Recessive Parkinsonism	NGF POLG	2.37e-04	28	24	2	C0752100
Disease	Familial Juvenile Parkinsonism	NGF POLG	2.37e-04	28	24	2	C0752104
Disease	Ramsay Hunt Paralysis Syndrome	NGF POLG	2.37e-04	28	24	2	C0242423
Disease	Parkinsonism, Juvenile	NGF POLG	2.72e-04	30	24	2	C0752105
Disease	Parkinsonian Disorders	NGF POLG	2.72e-04	30	24	2	C0242422
Disease	mitochondrial metabolism disease (implicated_via_orthology)	NDUFS4 POLG	3.71e-04	35	24	2	DOID:700 (implicated_via_orthology)
Disease	Leigh Disease	NDUFS4 POLG	6.70e-04	47	24	2	C0023264
Disease	Mitochondrial Diseases	NDUFS4 POLG	7.28e-04	49	24	2	C0751651

Protein segments in the cluster

Peptide	Gene	Start	Entry
SRRVQEAAAAAAARE	AARD	76	Q4LEZ3
PAAAVVRAAVSASRA	DHX29	11	Q7Z478
ARVFLRAVRAALTST	C5orf38	6	Q86SI9
RASILARDCAAAAAI	ALPK1	96	Q96QP1
ERARARVAAKARVSA	MAGEB10	316	Q96LZ2
AARAAVDVAALVRRA	MAGIX	41	Q9H6Y5
TALRRARSAPAAAIA	NGF	46	P01138
LRRVTRAAAAAAAAT	INCENP	121	Q9NQS7
VRAAIRAARTACFVE	PLXND1	396	Q9Y4D7
AARVSVARARLALAA	PTGER1	146	P34995
VARARLALAAVAAVA	PTGER1	151	P34995
PAARRAAARSRAAAA	NRG2	76	O14511
SAQRDIAAAVRFTVV	OR1F2P	266	Q96R84
PVSRRAAAAAATVLL	SLC19A2	6	O60779
AAAAAATVLLRTARV	SLC19A2	11	O60779
RRLTAREAATAVAAL	RYR1	4321	P21817
RRRAVAVAALSVSRV	NDUFS4	16	O43181
EAVRRLQRAVAAVAA	FRAT2	191	O75474
VRPQRRAAAAAAAAA	POLG	51	A0A3B3IS91
AARIVVAAVARAAAR	TRMT1L	431	Q7Z2T5
AEVARARAALAVNIC	CCT6B	11	Q92526
RSGRAAALRQVVSAV	EPPK1	1491	P58107
SAARRDADARAVALA	SPSB3	16	Q6PJ21
RRAAIAQALAGEVSV	SMU1	141	Q2TAY7
AVQAERVRAVSASAL	SPTBN2	581	O15020
SARAAAAVVAAAART	TRUB1	36	Q8WWH5
RGRAAAAAAAAAVSR	ZFP91	56	Q96JP5
AAAAAAAVSRRRKAE	ZFP91	61	Q96JP5
VARAAAAFARRVLSL	TRIM56	301	Q9BRZ2
RAAVAELRAGAVVAV	YRDC	71	Q86U90