Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

RASGRP4 ADGRE2 VWCE LRP1B LDLR EGFEM1P CRB1 CD93 SCUBE1 FBN2 SCUBE2 ADGRE4P LRP2 UMOD LTBP1 LTBP4 FBN3 NOTCH4 PROS1

2.37e-0774912619GO:0005509
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP1B LDLR LRP2 LRP6

2.59e-06161264GO:0005041
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP1B LDLR LRP2 LRP6

8.32e-06211264GO:0030228
GeneOntologyMolecularFunctioncargo receptor activity

LRP1B LDLR EGFEM1P LRP2 LRP6

2.02e-04851265GO:0038024
GeneOntologyMolecularFunctiongrowth factor binding

CD109 SORT1 GLG1 LRP2 LTBP1 LTBP4

4.70e-041561266GO:0019838
GeneOntologyMolecularFunctiontransforming growth factor beta binding

CD109 LTBP1 LTBP4

5.74e-04261263GO:0050431
GeneOntologyMolecularFunctionubiquitin protein ligase activity

UBR4 COP1 PCGF3 RNF157 NEDD4 TRIM33 RNFT1 DZIP3 UBR3

5.96e-043721269GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

UBR4 COP1 PCGF3 RNF157 NEDD4 TRIM33 RNFT1 DZIP3 UBR3

9.61e-043981269GO:0061659
GeneOntologyCellularComponentmicrofibril

FBN2 LTBP1 LTBP4 FBN3

8.63e-07131264GO:0001527
GeneOntologyCellularComponentexternal encapsulating structure

COL6A6 MUC5B PKHD1L1 FBN2 OTOGL GLG1 AHSG LTBP1 ALB LOXL3 ADAMTS14 USH2A LTBP4 FBN3

4.38e-0565812614GO:0030312
GeneOntologyCellularComponentextracellular matrix

COL6A6 MUC5B FBN2 OTOGL GLG1 AHSG LTBP1 ALB LOXL3 ADAMTS14 USH2A LTBP4 FBN3

1.68e-0465612613GO:0031012
MousePhenosmall alisphenoid bone

GAS1 SCUBE1 MN1

3.07e-0591023MP:0004459
MousePhenoabsent paraxial mesoderm

DDX12P MECOM LRP6

3.07e-0591023MP:0012184
MousePhenodecreased circulating transferrin level

LRP1B LDLR UMOD

4.36e-05101023MP:0011894
DomainEGF_CA

ADGRE2 VWCE LRP1B LDLR CRB1 CD93 SCUBE1 FBN2 SCUBE2 ADGRE4P LRP2 UMOD LTBP1 LTBP4 FBN3 NOTCH4 PROS1

5.97e-209912017PS01187
DomainASX_HYDROXYL

ADGRE2 VWCE LRP1B LDLR CRB1 CD93 SCUBE1 FBN2 SCUBE2 ADGRE4P LRP2 UMOD LTBP1 LTBP4 FBN3 NOTCH4 PROS1

7.16e-2010012017PS00010
DomainEGF_CA

ADGRE2 VWCE LRP1B LDLR CD93 SCUBE1 FBN2 SCUBE2 ADGRE4P LRP2 UMOD LTBP1 LTBP4 FBN3 NOTCH4 PROS1

1.99e-198612016PF07645
DomainEGF-type_Asp/Asn_hydroxyl_site

ADGRE2 VWCE LRP1B LDLR CRB1 CD93 SCUBE1 FBN2 SCUBE2 ADGRE4P LRP2 UMOD LTBP1 LTBP4 FBN3 NOTCH4 PROS1

2.04e-1910612017IPR000152
DomainGrowth_fac_rcpt_

ELAPOR2 RSPO4 ADGRE2 VWCE LRP1B LDLR CRB1 CD93 SCUBE1 FBN2 SCUBE2 LRP2 UMOD LTBP1 C9 LTBP4 FBN3 NOTCH4 PROS1

3.03e-1915612019IPR009030
DomainEGF_Ca-bd_CS

ADGRE2 VWCE LRP1B LDLR CRB1 CD93 SCUBE1 FBN2 SCUBE2 LRP2 UMOD LTBP1 LTBP4 FBN3 NOTCH4 PROS1

1.54e-189712016IPR018097
DomainEGF-like_Ca-bd_dom

ADGRE2 VWCE LRP1B LDLR CRB1 CD93 SCUBE1 FBN2 SCUBE2 ADGRE4P LRP2 UMOD LTBP1 LTBP4 FBN3 NOTCH4 PROS1

3.28e-1812412017IPR001881
DomainEGF

ADGRE2 VWCE LRP1B LDLR CRB1 CD93 SCUBE1 FBN2 MALRD1 SCUBE2 ADGRE4P BRINP2 LRP2 LRP6 UMOD LTBP1 LTBP4 FBN3 NOTCH4 PROS1

4.24e-1723512020SM00181
DomainEGF_3

ADGRE2 VWCE LRP1B LDLR CRB1 CD93 SCUBE1 FBN2 MALRD1 SCUBE2 ADGRE4P LRP2 LRP6 UMOD LTBP1 C9 LTBP4 FBN3 NOTCH4 PROS1

4.24e-1723512020PS50026
DomainEGF_CA

ADGRE2 VWCE LRP1B LDLR CRB1 CD93 SCUBE1 FBN2 SCUBE2 LRP2 UMOD LTBP1 LTBP4 FBN3 NOTCH4 PROS1

7.02e-1712212016SM00179
DomainEGF-like_dom

ADGRE2 VWCE LRP1B LDLR CRB1 CD93 SCUBE1 FBN2 MALRD1 SCUBE2 ADGRE4P LRP2 LRP6 UMOD LTBP1 C9 LTBP4 FBN3 NOTCH4 PROS1

1.32e-1624912020IPR000742
DomainEGF_1

ADGRE2 VWCE LRP1B LDLR CRB1 SCUBE1 FBN2 MALRD1 SCUBE2 LRP2 LRP6 UMOD LTBP1 C9 USH2A LTBP4 FBN3 NOTCH4 PROS1

3.24e-1525512019PS00022
DomainEGF-like_CS

ADGRE2 VWCE LRP1B LDLR CRB1 CD93 SCUBE1 FBN2 MALRD1 SCUBE2 LRP2 LRP6 UMOD LTBP1 C9 LTBP4 FBN3 NOTCH4 PROS1

4.96e-1526112019IPR013032
DomainEGF_2

ADGRE2 VWCE LRP1B LDLR CRB1 CD93 SCUBE1 FBN2 MALRD1 SCUBE2 LRP2 LRP6 UMOD LTBP1 C9 LTBP4 FBN3 NOTCH4 PROS1

6.55e-1526512019PS01186
DomaincEGF

LRP1B CD93 SCUBE1 FBN2 SCUBE2 LRP2 LTBP1 FBN3

3.25e-12261208PF12662
DomaincEGF

LRP1B CD93 SCUBE1 FBN2 SCUBE2 LRP2 LTBP1 FBN3

3.25e-12261208IPR026823
DomainEGF

LRP1B CRB1 CD93 MALRD1 SCUBE2 LRP2 LRP6 UMOD LTBP1 FBN3 NOTCH4 PROS1

2.97e-1112612012PF00008
DomainTB

FBN2 LTBP1 LTBP4 FBN3

5.59e-0871204PF00683
Domain-

FBN2 LTBP1 LTBP4 FBN3

1.11e-07812043.90.290.10
DomainLDLR_class-A_CS

LRP1B LDLR MALRD1 LRP2 LRP6 C9

1.99e-07401206IPR023415
DomainTB_dom

FBN2 LTBP1 LTBP4 FBN3

1.99e-0791204IPR017878
DomainTB

FBN2 LTBP1 LTBP4 FBN3

1.99e-0791204PS51364
DomainLdl_recept_a

LRP1B LDLR MALRD1 LRP2 LRP6 C9

4.12e-07451206PF00057
Domain-

LRP1B LDLR MALRD1 LRP2 LRP6 C9

4.71e-074612064.10.400.10
DomainLDLRA_1

LRP1B LDLR MALRD1 LRP2 LRP6 C9

6.11e-07481206PS01209
DomainLDrepeatLR_classA_rpt

LRP1B LDLR MALRD1 LRP2 LRP6 C9

6.92e-07491206IPR002172
DomainLDLa

LRP1B LDLR MALRD1 LRP2 LRP6 C9

6.92e-07491206SM00192
DomainLDLRA_2

LRP1B LDLR MALRD1 LRP2 LRP6 C9

6.92e-07491206PS50068
DomainLdl_recept_b

LRP1B LDLR LRP2 LRP6

1.54e-06141204PF00058
DomainLDLRB

LRP1B LDLR LRP2 LRP6

1.54e-06141204PS51120
DomainLY

LRP1B LDLR LRP2 LRP6

2.09e-06151204SM00135
DomainLDLR_classB_rpt

LRP1B LDLR LRP2 LRP6

2.09e-06151204IPR000033
DomainhEGF

CRB1 FBN2 FBN3 NOTCH4

2.95e-05281204PF12661
DomainEGF_dom

SCUBE1 SCUBE2 UMOD

5.45e-05121203IPR024731
DomainEGF_3

SCUBE1 SCUBE2 UMOD

5.45e-05121203PF12947
Domain-

LRP1B LDLR LRP2 LRP6

1.12e-043912042.120.10.30
DomainFBN

FBN2 FBN3

1.22e-0431202IPR011398
Domain-

DPF1 ZNF521 COP1 PCGF3 RNF157 TRIM33 PYGO2 RNFT1 DZIP3 UBR3 ZFYVE26

1.51e-04449120113.30.40.10
DomainZnf_RING/FYVE/PHD

DPF1 ZNF521 COP1 PCGF3 RNF157 TRIM33 PYGO2 RNFT1 DZIP3 UBR3 ZFYVE26

1.83e-0445912011IPR013083
Domainzf-C2H2_6

ZNF597 ZNF765 ZNF845 ZNF211 ZNF521 MECOM GZF1 ZNF660 ZNF197

1.95e-043141209PF13912
Domain6-blade_b-propeller_TolB-like

LRP1B LDLR LRP2 LRP6

2.15e-04461204IPR011042
DomainALBUMIN

GC ALB

2.44e-0441202SM00103
DomainSerum_albumin_N

GC ALB

2.44e-0441202IPR014760
DomainLamGL

PAPPA USH2A

2.44e-0441202SM00560
DomainSerum_albumin_CS

GC ALB

2.44e-0441202IPR020857
DomainLamG-like

PAPPA USH2A

2.44e-0441202IPR006558
DomainALBUMIN_2

GC ALB

2.44e-0441202PS51438
DomainALBUMIN_1

GC ALB

2.44e-0441202PS00212
DomainSerum_albumin

GC ALB

2.44e-0441202PF00273
DomainSerum_albumin-like

GC ALB

4.04e-0451202IPR020858
DomainEphrin_rec_like

ELAPOR2 SCUBE1 SCUBE2

5.37e-04251203SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

ELAPOR2 SCUBE1 SCUBE2

5.37e-04251203IPR011641
DomainGDNF

GFRAL GAS1

6.04e-0461202PF02351
DomainGDNF

GFRAL GAS1

6.04e-0461202SM00907
DomainGDNF/GAS1

GFRAL GAS1

6.04e-0461202IPR016017
DomainALB/AFP/VDB

GC ALB

6.04e-0461202IPR000264
DomainVWC

CHRDL2 MUC5B VWCE

7.54e-04281203PF00093
DomainTSP1

UNC5B RSPO4 ADAMTS14 C9

8.11e-04651204SM00209
DomainTSP1_rpt

UNC5B RSPO4 ADAMTS14 C9

8.11e-04651204IPR000884
DomainTSP1

UNC5B RSPO4 ADAMTS14 C9

8.11e-04651204PS50092
DomainNotch_dom

PAPPA NOTCH4

8.42e-0471202IPR000800
DomainZnF_UBR1

UBR4 UBR3

8.42e-0471202SM00396
DomainZF_UBR

UBR4 UBR3

8.42e-0471202PS51157
DomainNotch

PAPPA NOTCH4

8.42e-0471202PF00066
Domainzf-UBR

UBR4 UBR3

8.42e-0471202PF02207
DomainZnf_UBR

UBR4 UBR3

8.42e-0471202IPR003126
DomainNL

PAPPA NOTCH4

8.42e-0471202SM00004
DomainZnf_RING

DPF1 COP1 PCGF3 RNF157 TRIM33 RNFT1 DZIP3 UBR3

1.22e-033261208IPR001841
DomainZINC_FINGER_C2H2_1

ZNF597 ZNF765 ZNF536 ZNF845 TUT4 ZNF211 ZNF521 MECOM ZBTB1 GZF1 ZNF660 ZNF608 ZNF197

1.47e-0377712013PS00028
DomainVWFC_1

CHRDL2 MUC5B VWCE

1.58e-03361203PS01208
DomainMAC_perforin

BRINP2 C9

1.78e-03101202IPR001862
DomainZnf_C2H2-like

ZNF597 ZNF765 ZNF536 ZNF845 ZNF211 ZNF521 MECOM ZBTB1 GZF1 ZNF660 ZNF608 ZNF197 ZNF638

1.82e-0379612013IPR015880
DomainVWFC_2

CHRDL2 MUC5B VWCE

1.85e-03381203PS50184
DomainVWC

CHRDL2 MUC5B VWCE

1.85e-03381203SM00214
DomainLAM_G_DOMAIN

CRB1 USH2A PROS1

1.85e-03381203PS50025
DomainZnf_C2H2

ZNF597 ZNF765 ZNF536 ZNF845 ZNF211 ZNF521 MECOM ZBTB1 GZF1 ZNF660 ZNF608 ZNF197 ZNF638

2.01e-0380512013IPR007087
DomainZnF_C2H2

ZNF597 ZNF765 ZNF536 ZNF845 ZNF211 ZNF521 MECOM ZBTB1 GZF1 ZNF660 ZNF608 ZNF197 ZNF638

2.07e-0380812013SM00355
DomainLaminin_G_2

CRB1 USH2A PROS1

2.15e-03401203PF02210
DomainEphrin_rec_like

SCUBE1 SCUBE2

2.17e-03111202PF07699
DomainMACPF

BRINP2 C9

2.17e-03111202PF01823
DomainVWF_dom

CHRDL2 MUC5B VWCE

2.47e-03421203IPR001007
DomainMACPF

BRINP2 C9

2.59e-03121202IPR020864
DomainMACPF

BRINP2 C9

2.59e-03121202SM00457
DomainZF_RING_1

COP1 PCGF3 RNF157 TRIM33 RNFT1 DZIP3 UBR3

2.76e-032911207PS00518
DomainLamG

CRB1 USH2A PROS1

2.83e-03441203SM00282
DomainZF_RING_2

COP1 PCGF3 RNF157 TRIM33 RNFT1 DZIP3 UBR3

3.15e-032981207PS50089
Domainzf-C3HC4

COP1 PCGF3 RNF157 RNFT1 DZIP3 UBR3

3.20e-032231206PF00097
Domain-

CRB1 PAPPA USH2A PROS1

3.29e-039512042.60.120.200
DomainZF_PHD_2

DPF1 TRIM33 PYGO2 ASXL3

3.29e-03951204PS50016
DomainZF_PHD_1

DPF1 TRIM33 PYGO2 ASXL3

3.42e-03961204PS01359
DomainTIL_dom

MUC5B LRP2

3.54e-03141202IPR002919
DomainRING

DPF1 COP1 PCGF3 RNF157 TRIM33 RNFT1 DZIP3

3.58e-033051207SM00184
DomainZINC_FINGER_C2H2_2

ZNF597 ZNF765 ZNF536 ZNF845 ZNF211 ZNF521 MECOM ZBTB1 GZF1 ZNF660 ZNF608 ZNF197

4.19e-0377512012PS50157
Domain-

ZNF597 ZNF765 ZNF536 ZNF845 ZNF211 ZNF521 MECOM ZBTB1 GZF1 ZNF660 ZNF197

4.35e-03679120113.30.160.60
Domainzf-C2H2

ZNF597 ZNF765 ZNF536 ZNF845 ZNF211 ZNF521 MECOM ZBTB1 GZF1 ZNF660 ZNF197

5.06e-0369312011PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF597 ZNF765 ZNF536 ZNF845 ZNF211 ZNF521 MECOM ZBTB1 GZF1 ZNF660 ZNF197

5.11e-0369412011IPR013087
DomainLaminin_G

CRB1 USH2A PROS1

6.17e-03581203IPR001791
DomainARM-type_fold

TNPO1 UBR4 APC LYST PKP1 PRKDC STAG3

6.32e-033391207IPR016024
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN2 LTBP1 LOXL3 LTBP4 FBN3

6.03e-0644845M26969
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FLNA FBN2 LTBP1 FBN3

1.35e-0525844M39713
PathwayWP_COMPLEMENT_SYSTEM

CD93 LRP2 CD59 ALB C9 PROS1

2.26e-0596846M39581
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN2 LTBP1 LTBP4 FBN3

6.67e-0537844M27134
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN2 LTBP1 LOXL3 LTBP4

8.23e-0539844MM14601
Pubmed

Interaction network of human early embryonic transcription factors.

DPF1 TNPO1 ZNF536 SOBP ZNF521 MECOM PCGF3 SORT1 TRIM33 PYGO2 ZNF608 ASXL3 ALB

6.11e-103511271338297188
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

FLNA ZNF536 UBR4 APC MECOM ZDBF2 ZBTB1 ZNF608 ATF7IP2 LRP2 TMF1 ARHGAP21

4.81e-084181271234709266
Pubmed

Human transcription factor protein interaction networks.

DPF1 ZNF536 SOBP CNOT10 UBR4 ZNF521 COP1 MECOM USP46 EDC4 PCGF3 ZBTB1 TRIM33 FBN2 BBX PYGO2 ZNF608 ZNF638 LRP2 LRP6 USP54

5.36e-0814291272135140242
Pubmed

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

FBN2 LTBP1 LTBP4

1.90e-074127312429738
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

LRP1B LDLR LRP2 LRP6

9.67e-0721127421337463
Pubmed

DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.

APC LRP6 PRKDC

1.65e-067127329431745
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

FLII CNST UBR4 BACH1 APC ZNF521 REV3L LRP1B ZBED5 TRIM33 ZNF660 ZNF197 LRP2 PDZD8 PRKDC USP54 ARHGAP21

4.63e-0612851271735914814
Pubmed

Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.

MECOM LRP1B LRP2 MN1

5.63e-0632127425189868
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1B LRP2 LRP6

7.68e-0611127324639464
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

TNPO1 ZNF536 UBR4 MECOM ZDBF2 TRIM33 AKAP11 ENOX2

9.86e-06282127823667531
Pubmed

PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation.

APC MECOM PYGO2

1.02e-0512127335132438
Pubmed

Epithelialization of mouse ovarian tumor cells originating in the fallopian tube stroma.

PTEN DICER1

1.32e-052127227602775
Pubmed

An immunocompromised murine model of chronic Bartonella infection.

LYST PRKDC

1.32e-052127220395436
Pubmed

alpha2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression.

APC AHSG

1.32e-052127215374947
Pubmed

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.

LDLR SORT1

1.32e-052127226950419
Pubmed

Nonspecific immune responses and mechanisms of resistance to Eimeria papillata infections in mice.

LYST PRKDC

1.32e-05212729234770
Pubmed

Megalin/gp330 mediates uptake of albumin in renal proximal tubule.

LRP2 ALB

1.32e-05212728898021
Pubmed

Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice.

LYST PRKDC

1.32e-052127217392156
Pubmed

Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin.

LDLR SORT1

1.32e-052127229899496
Pubmed

NEDD4 Depletion Inhibits Hepatocellular Carcinoma Growth via Targeting PTEN.

PTEN NEDD4

1.32e-052127227467187
Pubmed

Signs and lesions of experimental Sendai virus infection in two genetically distinct strains of SCID/beige mice.

LYST PRKDC

1.32e-05212728140728
Pubmed

Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis.

APC LRP6

1.32e-052127234359960
Pubmed

Spontaneous and experimental infections in scid and scid/beige mice.

LYST PRKDC

1.32e-05212728320959
Pubmed

Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas.

PTEN NEDD4

1.32e-052127220889565
Pubmed

Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status.

APC LYST

1.32e-05212729041176
Pubmed

Ischemia-modified albumin in pregnancy.

PAPPA ALB

1.32e-052127223891063
Pubmed

Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk.

PTEN DICER1

1.32e-052127221278735
Pubmed

Prevalence of APC and PTEN Alterations in Urachal Cancer.

APC PTEN

1.32e-052127232754865
Pubmed

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.

LDLR SORT1

1.32e-052127220816088
Pubmed

ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors.

LYST PRKDC

1.32e-052127219249873
Pubmed

Studies of virus-induced myocardial injury in mice: value of the scid mutation on different genetic backgrounds and combined with other mutations.

LYST PRKDC

1.32e-05212728391609
Pubmed

Murine granulated metrial gland cell population in beige (bg/bg) and SCID (scid/scid) genotypes.

LYST PRKDC

1.32e-05212728075241
Pubmed

SCID-bg mice as xenograft recipients.

LYST PRKDC

1.32e-05212729175014
Pubmed

Identity of a peptide domain of human C9 that is bound by the cell-surface complement inhibitor, CD59.

CD59 C9

1.32e-05212727523406
Pubmed

The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.

LDLR LRP6

1.32e-052127224506864
Pubmed

Comparison of susceptibility of inbred and outbred infant mice to Escherichia coli heat-stable enterotoxin STa.

LYST PRKDC

1.32e-05212721639480
Pubmed

Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice.

LYST LDLR

1.32e-052127215175354
Pubmed

Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.

PTEN NEDD4

1.32e-052127228714370
Pubmed

Application of a high-throughput genotyping method for loci exclusion in non-consanguineous Australian pedigrees with autosomal recessive retinitis pigmentosa.

CRB1 USH2A

1.32e-052127222876132
Pubmed

Additive effects of the combined expression of soluble forms of GAS1 and PTEN inhibiting glioblastoma growth.

GAS1 PTEN

1.32e-052127229941984
Pubmed

Translocation of bacteria from the gastrointestinal tract in immunodeficient mice.

LYST PRKDC

1.32e-05212728709573
Pubmed

Frequency and histological appearance of adenomas in multiple intestinal neoplasia mice are unaffected by severe combined immunodeficiency (scid) mutation.

APC PRKDC

1.32e-05212728567125
Pubmed

[Nedd4/PTEN in axonal branching].

PTEN NEDD4

1.32e-052127220819705
Pubmed

Protective immunity to HIV-1 in SCID/beige mice reconstituted with peripheral blood lymphocytes of exposed but uninfected individuals.

LYST PRKDC

1.32e-05212728962121
Pubmed

LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake.

LDLR LRP6

1.32e-052127222128165
Pubmed

Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc.

PTEN NEDD4

1.32e-052127220100827
Pubmed

Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cells.

LYST PRKDC

1.32e-052127223094018
Pubmed

Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age.

CRB1 CD59

1.32e-052127226234657
Pubmed

The Relationship between the Methylation of Promoter Regions of Tumor Suppressor Genes PTEN and APC with Endometrial Cancer.

APC PTEN

1.32e-052127231450893
Pubmed

Branhamella catarrhalis pathogenesis in SCID and SCID/beige mice. Brief report.

LYST PRKDC

1.32e-05212728267959
Pubmed

Epithelial phosphatase and tensin homolog regulates intestinal architecture and secretory cell commitment and acts as a modifier gene in neoplasia.

APC PTEN

1.32e-052127219168705
Pubmed

Thyroid nodules with DICER1 mutation or PTEN alteration: A comparative cytologic, clinical, and molecular study of 117 FNA cases.

PTEN DICER1

1.32e-052127238558329
Pubmed

A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.

LDLR SORT1

1.32e-052127227318830
Pubmed

Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?

PTEN NEDD4

1.32e-052127223180960
Pubmed

Hyodeoxycholic acid efficiently suppresses atherosclerosis formation and plasma cholesterol levels in mice.

APC LDLR

1.32e-052127211483626
Pubmed

Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.

PTEN NEDD4

1.32e-052127233712741
Pubmed

The beneficial effect of blocking Kv1.3 in the psoriasiform SCID mouse model.

LYST PRKDC

1.32e-052127220739949
Pubmed

Infection of the laboratory mouse with the intracellular pathogen Ehrlichia chaffeensis.

LYST PRKDC

1.32e-05212729673277
Pubmed

Ubiquitination regulates PTEN nuclear import and tumor suppression.

PTEN NEDD4

1.32e-052127217218261
Pubmed

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.

PTEN NEDD4

1.32e-052127217218260
Pubmed

Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation.

LYST PRKDC

1.32e-05212728418200
Pubmed

Brief report: accelerated atherosclerosis in low-density lipoprotein receptor-deficient mice lacking the membrane-bound complement regulator CD59.

LDLR CD59

1.32e-052127218617646
Pubmed

Mycobacterium avium subspecies paratuberculosis triggers intestinal pathophysiologic changes in beige/scid mice.

LYST PRKDC

1.32e-052127211924817
Pubmed

Postreplicative joining of DNA double-strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts.

PTEN PRKDC

1.32e-052127216288010
Pubmed

Hypercholesterolemia induces T cell expansion in humanized immune mice.

LDLR PRKDC

1.32e-052127229708512
Pubmed

Defining the CD59-C9 binding interaction.

CD59 C9

1.32e-052127216844690
Pubmed

Differential expression of tumor-associated genes and altered gut microbiome with decreased Akkermansia muciniphila confer a tumor-preventive microenvironment in intestinal epithelial Pten-deficient mice.

APC PTEN

1.32e-052127230292635
Pubmed

Mechanisms of albumin uptake by proximal tubular cells.

LRP2 ALB

1.32e-052127211158855
Pubmed

A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis.

PTEN DICER1

1.32e-052127223851498
Pubmed

Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease.

LDLR LRP6

1.32e-052127226489464
Pubmed

Intestinal knockout of Nedd4 enhances growth of Apcmin tumors.

APC NEDD4

1.32e-052127227086928
Pubmed

Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors.

LYST PRKDC

1.32e-052127210225324
Pubmed

MN1 and PTEN gene expression in acute myeloid leukemia.

PTEN MN1

1.32e-052127227983532
Pubmed

Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice.

APC LDLR

1.32e-052127219544529
Pubmed

Stage-specific association of apolipoprotein A-I and E in developing mouse retina.

LDLR LRP2 LRP6

1.68e-0514127317389516
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

GAS1 CD109 ADGRE2 LRP1B LDLR P3H4 SORT1 FBN2 GLG1 RNFT1 CD59 LRP6 LTBP1 ARHGAP21 PROS1

3.41e-0512011271535696571
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

CD109 LDLR PAPPA LTBP1 LOXL3 LTBP4 PROS1

3.72e-05248127724006456
Pubmed

Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation.

PTEN NEDD4

3.96e-053127218498243
Pubmed

PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine.

APC PTEN

3.96e-053127224293351
Pubmed

Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.

LDLR LRP6

3.96e-053127226034040
Pubmed

Live cell imaging of outward and inward vesiculation induced by the complement c5b-9 complex.

CD59 C9

3.96e-053127217644516
Pubmed

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).

GC LRP2

3.96e-053127211717447
Pubmed

Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin.

APC PTEN

3.96e-053127217693663
Pubmed

Identification of a novel family of cell-surface proteins expressed in human vascular endothelium.

SCUBE1 SCUBE2

3.96e-053127212270931
Pubmed

Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease.

LRP2 ALB

3.96e-053127228356267
Pubmed

Loxl3 Promotes Melanoma Progression and Dissemination Influencing Cell Plasticity and Survival.

PTEN LOXL3

3.96e-053127235267510
Pubmed

High-grade serous ovarian cancer arises from fallopian tube in a mouse model.

PTEN DICER1

3.96e-053127222331912
Pubmed

PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.

PTEN DICER1

3.96e-053127228620008
Pubmed

Correlation of plasma soluble cluster of differentiation 40 ligand, alpha fetoprotein A, and pregnancy-associated plasma protein A with carotid plaque in patients with ischemic stroke.

AHSG PAPPA

3.96e-053127226214492
Pubmed

Adenoma multiplicity in irradiated Apc(Min) mice is modified by chromosome 16 segments from BALB/c.

APC PRKDC

3.96e-053127212750251
Pubmed

Pulmonary alveolar proteinosis. A spontaneous and inducible disease in immunodeficient germ-free mice.

LYST PRKDC

3.96e-05312727717446
Pubmed

PUM2 promoted osteoarthritis progression through PTEN-mediated chondrocyte ferroptosis by facilitating NEDD4 mRNA degradation.

PTEN NEDD4

3.96e-053127238733337
Pubmed

Preclinical testing of PI3K/AKT/mTOR signaling inhibitors in a mouse model of ovarian endometrioid adenocarcinoma.

APC PTEN

3.96e-053127221903772
Pubmed

Prostate cancer induced by loss of Apc is restrained by TGFβ signaling.

APC PTEN

3.96e-053127224651496
Pubmed

A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains.

APC PTEN

3.96e-053127222434720
Pubmed

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation.

APC PTEN

3.96e-053127219011632
Pubmed

ΔNp63α represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes.

PTEN NEDD4

3.96e-053127223589096
Pubmed

Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production.

PTEN NEDD4

3.96e-053127221986318
Pubmed

Dicer1 facilitates liver regeneration in a manner dependent on the inhibitory effect of miR-21 on Pten and Rhob expression.

PTEN DICER1

3.96e-053127231306658
Pubmed

Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.

LRP2 ALB

3.96e-053127210811843
InteractionNTN5 interactions

APC LRP1B LDLR FBN2 LRP2 LTBP1 LTBP4

1.00e-10241267int:NTN5
InteractionFOXD4L6 interactions

LRP1B LDLR DICER1 FBN2 DHX32 LTBP4

5.95e-07491266int:FOXD4L6
InteractionZFP41 interactions

LRP1B LDLR FBN2 LRP2 LTBP1 LTBP4

1.48e-06571266int:ZFP41
InteractionPRG2 interactions

LDLR DICER1 P3H4 MTFR1L FBN2 GLG1 LRP6 PAPPA ADAMTS14 LTBP4 PROS1

1.80e-0628512611int:PRG2
InteractionZNF408 interactions

APC VWCE LRP1B LDLR FBN2 LRP2 LTBP1 LTBP4

3.63e-061451268int:ZNF408
InteractionERG interactions

DPF1 UBR4 ZNF521 ZBED5 NEDD4 TRIM33 PYGO2 ZNF608 PRKDC

1.14e-052231269int:ERG
InteractionEGR2 interactions

DPF1 ZNF536 ZNF521 MECOM PCGF3 TRIM33 PYGO2 ZNF608

1.22e-051711268int:EGR2
InteractionTIMP3 interactions

UBR4 VWCE LRP1B LDLR LRP2 AKAP11

2.15e-05901266int:TIMP3
InteractionNMS interactions

CD109 LRP1B GLG1 LRP6

3.52e-05301264int:NMS
InteractionFBN2 interactions

PTEN VWCE TRIM33 FBN2 LTBP1

5.40e-05651265int:FBN2
InteractionPHF21A interactions

FLNA ZNF536 UBR4 APC MECOM ZDBF2 ZBTB1 DZIP3 TMF1 ARHGAP21

6.01e-0534312610int:PHF21A
GeneFamilyLow density lipoprotein receptors

LRP1B LDLR LRP2 LRP6

3.46e-0713874634
GeneFamilyLatent transforming growth factor beta binding proteins

LTBP1 LTBP4

1.36e-044872628
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF597 ZNF765 ZNF536 ZNF845 ZNF211 ZNF521 MECOM ZBTB1 GZF1 ZNF660 ZNF608 ZNF197

1.62e-04718871228
GeneFamilyCD molecules|Adhesion G protein-coupled receptors, subfamily E

ADGRE2 ADGRE4P

2.27e-045872915
GeneFamilyUbiquitin protein ligase E3 component n-recognins

UBR4 UBR3

4.73e-047872785
GeneFamilyRing finger proteins

COP1 PCGF3 RNF157 TRIM33 RNFT1 DZIP3

2.12e-0327587658
CoexpressionNABA_MATRISOME

CHRDL2 COL6A6 CD109 RSPO4 MUC5B VWCE CD209 EGFEM1P SCUBE1 FBN2 SCUBE2 OTOGL BRINP2 PAPPA LTBP1 LOXL3 ADAMTS14 LTBP4

1.82e-06100812718MM17056
CoexpressionNABA_MATRISOME

CHRDL2 COL6A6 CD109 RSPO4 MUC5B VWCE CD209 SCUBE1 FBN2 SCUBE2 BRINP2 PAPPA LTBP1 LOXL3 ADAMTS14 USH2A LTBP4 FBN3

2.34e-06102612718M5889
CoexpressionSHIN_B_CELL_LYMPHOMA_CLUSTER_7

APC PTEN DICER1 NOTCH4

8.46e-06271274M1391
CoexpressionSHIN_B_CELL_LYMPHOMA_CLUSTER_7

APC PTEN DICER1 NOTCH4

8.46e-06271274MM1135
CoexpressionNABA_ECM_GLYCOPROTEINS

RSPO4 VWCE EGFEM1P FBN2 OTOGL LTBP1 LTBP4

4.18e-051911277MM17059
CoexpressionGSE9509_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_20MIN_UP

CNST GAS1 ZNF521 MECOM LRP6 NOTCH4 PROS1

4.77e-051951277M6899
CoexpressionNABA_ECM_GLYCOPROTEINS

RSPO4 VWCE FBN2 LTBP1 USH2A LTBP4 FBN3

4.92e-051961277M3008
CoexpressionNABA_CORE_MATRISOME

COL6A6 RSPO4 VWCE EGFEM1P FBN2 OTOGL LTBP1 LTBP4

5.32e-052701278MM17057
CoexpressionGSE17721_PAM3CSK4_VS_CPG_2H_BMDC_DN

RNF157 RNFT1 LRP2 ATP11A LOXL3 STAG3 ARHGAP21

5.59e-052001277M3858
CoexpressionDESCARTES_FETAL_THYMUS_STROMAL_CELLS

COL6A6 GAS1 ZDBF2 P3H4 FBN2 LTBP4

5.62e-051371276M40313
CoexpressionNABA_CORE_MATRISOME

COL6A6 RSPO4 VWCE FBN2 LTBP1 USH2A LTBP4 FBN3

6.05e-052751278M5884
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

TNPO1 TUT4 APC REV3L PTEN TRIM33 BBX ZNF638 TMF1 AKAP11 PROS1 ENOX2

8.56e-0565612712M18979
CoexpressionASTON_MAJOR_DEPRESSIVE_DISORDER_UP

APC REV3L LTBP1 MN1

9.41e-05491274M25
CoexpressionMARTINEZ_RB1_TARGETS_DN

FLNA UNC5B GAS1 ZNF521 EDC4 SORT1 FBN2 ATF7IP2 ATP11A LTBP1 ENOX2

1.05e-0456912711M12701
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000

DPF1 ZNF536 TUT4 SOBP MECOM ZDBF2 REV3L LDLR DICER1 SORT1 SCUBE1 SCUBE2 LRP2 PAPPA DHX32 PRKDC CCDC171 ARHGAP21

1.40e-0598912218Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ARHGAP42 ZNF536 LMCD1 SCUBE1 OTOGL PAPPA LTBP1 STAG3

1.35e-081521278621e9b33cd3bb1c7b7d0633069f286b203e3d9c0
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MUC5B LRP1B PKHD1L1 CRB1 FBN2 LRP2 USH2A CACNA2D3

2.01e-081601278c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MUC5B LRP1B PKHD1L1 CRB1 FBN2 LRP2 USH2A CACNA2D3

2.01e-08160127825c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MUC5B LRP1B PKHD1L1 FBN2 OTOGL ASXL3 LRP2 USH2A

5.95e-0818412782cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MUC5B LRP1B PKHD1L1 FBN2 OTOGL ASXL3 LRP2 USH2A

5.95e-081841278ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MUC5B LRP1B PKHD1L1 FBN2 OTOGL ASXL3 LRP2 USH2A

5.95e-0818412782b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP42 COL6A6 GAS1 REV3L ADGRE2 SCUBE2 LTBP1 LTBP4

8.26e-081921278df1545670370fb1010c567cd059c2783eab315f7
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_dendritic-CD141-positive_myeloid_dendritic_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

UNC5B CD109 ZNF521 MECOM EGFEM1P CNNM1 MALRD1

3.62e-0715812774f3ea658e032555c2098d016475381c8d1071699
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FLNA BACH1 PTEN ADGRE2 CD93 FBXO38 CCDC149

3.94e-0716012776ed37d1fd0304932319d6b942502404115ff36a7
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ZNF597 ZNF845 CD109 ZNF608 ASXL3 STAG3 NOTCH4

6.17e-0717112771ae4b6a25bc9c1065cf5d95998ebcc70aee21ab5
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL6A6 GAS1 PKHD1L1 P3H4 PAPPA LTBP1 LTBP4

6.93e-071741277a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL6A6 GAS1 PKHD1L1 P3H4 LRP2 LTBP1 LTBP4

8.08e-071781277bcbdd45a2307f8aea14122fa0144b96b1f6eec48
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL6A6 GAS1 PKHD1L1 P3H4 LRP2 LTBP1 LTBP4

8.08e-071781277c413861148129be1ee94f2ceb5999840217eebe5
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

ARHGAP42 ZNF536 LMCD1 CNNM1 SCUBE1 PAPPA LTBP1

8.71e-07180127701f2e5d96016823482f89ba503d007d4bd88eeac
ToppCellfacs-Kidney-nan-3m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORT1 AHSG UMOD LTBP1 ALB LTBP4 PROS1

9.37e-0718212774c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCellPBMC-Severe-Hematopoietic-HSPC-HSPC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DPF1 CD109 ZNF521 MECOM MALRD1 ZNF660 CCDC171

1.01e-06184127751d0447699e3b8f01abbde83f26b748bc9f3c723
ToppCellPBMC-Severe-Hematopoietic-HSPC-HSPC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DPF1 CD109 ZNF521 MECOM MALRD1 ZNF660 CCDC171

1.01e-061841277f7b0bb45a9055ab34e98b251217f6ec38c75ca22
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COL6A6 GAS1 LRP1B PKHD1L1 P3H4 PAPPA LTBP1

1.01e-061841277607b55022de21ddb6a2d75e085df76df7abf6624
ToppCellPBMC-Severe-Hematopoietic-HSPC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

DPF1 CD109 ZNF521 MECOM MALRD1 ZNF660 CCDC171

1.01e-06184127726edbf84216538b80f1ffcc079ee6e385a71fbf9
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARHGAP42 ZNF536 LMCD1 SOBP ZNF521 PAPPA LTBP1

1.12e-061871277c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LMCD1 UNC5B CD109 MECOM CD93 LTBP1 NOTCH4

1.21e-061891277c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LMCD1 UNC5B CD109 MECOM CD93 LTBP4 NOTCH4

1.21e-061891277b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMCD1 UNC5B CD109 CD93 LTBP4 MN1 NOTCH4

1.25e-061901277bf9bc57a605c7e3979bc4f7260e6fb92c3eb8690
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

UNC5B CD109 MECOM CCDC149 LTBP1 LTBP4 NOTCH4

1.25e-061901277aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

ELAPOR2 MECOM LDLR ZNF608 LRP6 ATP11A USP54

1.29e-061911277e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LMCD1 UNC5B CD109 CD93 LTBP1 LTBP4 NOTCH4

1.64e-0619812775e781583908c4ee107d986904a646a7c6b8e3591
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

LMCD1 UNC5B CD109 ZNF521 CD93 MN1 NOTCH4

1.64e-0619812778689090bce9ab6e8f122426a404037e572c6713b
ToppCellwk_15-18-Mesenchymal-Fibroblast-Adventitial_fibro|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

COL6A6 GAS1 P3H4 FBN2 LTBP4 MN1 PROS1

1.70e-0619912778de6d7b2067b22cb9b5f01aa56a3803aebc4406d
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CHRDL2 COL6A6 REV3L LDLR LRP6 PAPPA LTBP1

1.70e-0619912778b86c69aaf60feff53aa782559cfece7342a23de
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TUT4 ZNF521 MECOM NEDD4 CD93 ZNF608 NOTCH4

1.76e-062001277dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

TUT4 CD109 ZNF521 MECOM CD93 ZNF608 NOTCH4

1.76e-062001277b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL6A6 GAS1 PKHD1L1 P3H4 LRP2 LTBP1

8.52e-061671276c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL6A6 GAS1 PKHD1L1 P3H4 LRP2 LTBP1

8.52e-061671276351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCell10x5'-lymph-node_spleen-Mast-Mast_cells|lymph-node_spleen / Manually curated celltypes from each tissue

RASGRP4 ZNF521 ALS2 SORT1 SCUBE1 MALRD1

8.82e-061681276650ad3ea52577887885d82457dbc04202ce3eb34
ToppCell10x5'-lymph-node_spleen-Mast|lymph-node_spleen / Manually curated celltypes from each tissue

RASGRP4 ZNF521 ALS2 SORT1 SCUBE1 MALRD1

8.82e-061681276e58ffbb57c81967766755c3f6f347b158a39cb0d
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1B PKHD1L1 WFDC2 OTOGL LRP2 USH2A

9.12e-06169127612bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellP28-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ELAPOR2 MECOM LDLR WFDC2 LRP2 ATP11A

9.44e-061701276d0ed3a8a7ad96c05641ec409b0a69c4fb094893c
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ARHGAP42 ZNF536 LMCD1 ZNF521 SCUBE1 LTBP1

1.04e-0517312761f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1B PKHD1L1 WFDC2 OTOGL LRP2 USH2A

1.04e-05173127666f37c1437705734b20601656fa4aa1d92ca30be
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1B PKHD1L1 WFDC2 OTOGL LRP2 USH2A

1.04e-051731276649b08a409095592cccf31883be69c754411280d
ToppCellwk_15-18-Mesenchymal-Chondrocyte-intermediate_chondrocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CHRDL2 ZNF521 MECOM FBN2 WFDC2 ADAMTS14

1.11e-051751276a84965d28438a4228d841b357c2cd75cf4b59a63
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL6A6 GAS1 PKHD1L1 LRP2 PAPPA CCDC171

1.23e-051781276a107dd98a07086ed0429116095ecda60c9dbef1e
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10|TCGA-Colorectal / Sample_Type by Project: Shred V9

RASGRP4 LMCD1 ZNF521 ADGRE2 CD93 NOTCH4

1.27e-051791276cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCell5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHRDL2 UNC5B PKHD1L1 SCUBE2 ANKRD30A PKP1

1.27e-0517912769fd9b136ecbcbd4e4f0d5875ede98d8d48608afb
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

MECOM MALRD1 ZNF608 ATF7IP2 ATP11A USP54

1.27e-051791276cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARHGAP42 FLNA ZNF536 LMCD1 SCUBE1 LTBP1

1.35e-05181127625915e2500430a902db37d79a749ce2990b69810
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLNA ZNF536 LMCD1 ZNF521 P3H4 LTBP1

1.35e-051811276d7e04e0ca549eac6d9b1192b6578f9b54943d54f
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ZNF536 LMCD1 SOBP REV3L PAPPA LTBP1

1.39e-051821276ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL6A6 GAS1 PKHD1L1 LRP2 PAPPA CCDC171

1.39e-0518212769966f42c338cbd471efa8ffc765a6ce93693aa75
ToppCellE18.5-samps-Mesenchymal-Myofibroblast|E18.5-samps / Age Group, Lineage, Cell class and subclass

ZNF536 LMCD1 ZNF521 RNFT1 ADAMTS14 PROS1

1.43e-051831276de08f9ea02b7244d5a8788064631d10f06565337
ToppCellBasal|World / shred by cell class for mouse tongue

GAS1 NEDD4 WFDC2 PAPPA LTBP1 LTBP4

1.43e-051831276c6729a207526ff4aa48176207b9353176f631fea
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A6 CD109 PKHD1L1 P3H4 PAPPA LTBP4

1.43e-051831276ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCellPBMC-Severe-Hematopoietic-HSPC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DPF1 CD109 ZNF521 MECOM ZNF660 CCDC171

1.48e-051841276a6169613c6493b947a176493f542368bfa935dab
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF536 UNC5B EGFEM1P FBN2 ZNF608 LTBP1

1.48e-051841276e2de27cee3ea80f9b7a9a7884ceceeaa67b3214a
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ELAPOR2 LDLR WFDC2 ATP11A USP54 CACNA2D3

1.48e-051841276ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCellCOVID-19_Moderate-HSPC|World / disease group, cell group and cell class

DPF1 ZNF521 MECOM NEDD4 ZNF660 CCDC171

1.48e-051841276ccc93babe1fcdeb66b78e1d8414357877a7c45bd
ToppCellPBMC-Severe-Hematopoietic-HSPC-HSPC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DPF1 CD109 ZNF521 MECOM ZNF660 CCDC171

1.48e-051841276cc01c19180861f491a8dc16d60fabd1215fc4525
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BACH1 REV3L ADGRE2 ZBTB1 CD93 GZF1

1.48e-051841276b45b1fdba13c8ed2a04a4fb3b62d8ad92785c768
ToppCellPBMC-Severe-Hematopoietic-HSPC-HSPC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DPF1 CD109 ZNF521 MECOM ZNF660 CCDC171

1.48e-051841276492c680f0769ba4e651d09c2e8e5d5d271ed08aa
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP42 ZNF536 LMCD1 PAPPA CCDC171 LTBP4

1.53e-0518512766712512100ccef456d2e2bd201d0987986c92ac9
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ELAPOR2 MECOM WFDC2 ATP11A USP54 CACNA2D3

1.53e-0518512760d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

ARHGAP42 ZNF536 LMCD1 UNC5B FBN2 CACNA2D3

1.53e-051851276427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNST CD109 CD93 SCUBE1 ATP11A NOTCH4

1.53e-051851276673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GAS1 MECOM VWCE FBN2 LTBP1 LTBP4

1.57e-0518612764d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCellControl-Epithelial-Club|World / Disease state, Lineage and Cell class

ARHGAP42 MECOM LDLR ZNF608 WFDC2 USP54

1.57e-0518612769798428691408e17ff2af2fe2d1b345f074d67e4
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ELAPOR2 LDLR WFDC2 ATP11A USP54 CACNA2D3

1.57e-051861276e83718fabb057100835d3357df407f283d23fe16
ToppCelldroplet-Lung-LUNG-1m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMCD1 ZNF521 PKHD1L1 CCDC149 AHSG LTBP1

1.62e-0518712769c9ae8725905ba0cfe407878006ed06c2480fb72
ToppCell15-Trachea-Epithelial-Secretory_progenitor|Trachea / Age, Tissue, Lineage and Cell class

FLNA MUC5B SCUBE2 WFDC2 BRINP2 FBN3

1.62e-051871276be9fce9e74b2f170a2067f1b31d802912a578329
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAS1 PKHD1L1 FBN2 LRP2 PAPPA LTBP4

1.62e-0518712764e553721fa5598cb211f44e3226280b7e6885484
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)-D175|Adult / Lineage, Cell type, age group and donor

CD109 NEDD4 CD93 ZNF608 PKP1 NOTCH4

1.62e-051871276f3548817f2fded5978137bb252cb628ac199e4f6
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAS1 PKHD1L1 FBN2 LRP2 PAPPA LTBP4

1.62e-051871276d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAS1 PKHD1L1 FBN2 LRP2 PAPPA LTBP4

1.62e-051871276827eae63fabf6892a82ce7779b5f395958d3d628
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LMCD1 UNC5B MECOM CD93 LTBP4 NOTCH4

1.62e-05187127666ebe1788d51b3e17bec6cdb219f709756b4e530
ToppCelldroplet-Lung-LUNG-1m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMCD1 ZNF521 PKHD1L1 CCDC149 AHSG LTBP1

1.62e-0518712769e9460e57cdc9cd0a0de2866b140e06d0bc19a8f
ToppCelldroplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LMCD1 ZNF521 PKHD1L1 AHSG LTBP1 LTBP4

1.67e-051881276dc52dd2957be3f40001f0a56f3d9ac9d66ea466e
ToppCellLPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

UNC5B CD109 ZNF521 NEDD4 CD93 NOTCH4

1.67e-051881276789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARHGAP42 FLNA ZNF536 LMCD1 SCUBE1 LTBP1

1.67e-0518812764d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARHGAP42 REV3L SCUBE1 FBN2 SCUBE2 PAPPA

1.67e-051881276997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCelldroplet-Lung-1m-Endothelial-lymphatic_endothelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LMCD1 ZNF521 PKHD1L1 AHSG LTBP1 LTBP4

1.67e-0518812762ef08313087e91985bcffc46c3798470cdeec49c
ToppCelldroplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LMCD1 ZNF521 PKHD1L1 AHSG LTBP1 LTBP4

1.67e-0518812761f1604b6dc0a8ad0be3d9aac0bef448459c22465
ToppCellsystemic_lupus_erythematosus-flare-Hematopoietic-progenitor_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DPF1 UNC5B ZNF521 MECOM ZNF660 ADAMTS14

1.67e-051881276c613c6c7b6de8ed514253c9f9b8622c56fcc1452
ToppCellMesenchymal-myofibroblast_cell|World / Lineage, Cell type, age group and donor

ARHGAP42 ZNF536 LMCD1 ZNF521 PAPPA LTBP1

1.72e-05189127644e37f88137bb249933eb615235b2cf2ae7f3925
ToppCellCOVID_vent-Myeloid-Monocytic-SC_&_Eosinophil|COVID_vent / Disease condition, Lineage, Cell class and subclass

CD109 ZNF521 MECOM NEDD4 PDZD8 CCDC171

1.72e-0518912762157a2d40613f7d5ce2e7dbd266df441e449cdaf
ToppCellCOVID-19_Severe-HSPC|World / disease group, cell group and cell class

DPF1 CD109 ZNF521 MECOM MALRD1 CCDC171

1.72e-051891276555c0b13f1508b9e3712b36d77144e73e828bc76
ToppCellCOVID-19_Severe-HSPC|COVID-19_Severe / disease group, cell group and cell class

DPF1 CD109 ZNF521 MECOM ZNF660 CCDC171

1.72e-05189127696015439971e2e5b8d6294ca5a6b873c7774e925
ToppCellLPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

UNC5B CD109 ZNF521 SORT1 CD93 NOTCH4

1.72e-051891276e82211b9dc7540e7a183be2cbcfae39fdf503949
ToppCellMesenchymal-airway_smooth_muscle_cell|World / Lineage, Cell type, age group and donor

ARHGAP42 FLNA ZNF536 LMCD1 SCUBE1 LTBP1

1.77e-051901276645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCelldroplet-Kidney-KIDNEY-30m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMCD1 CD109 CD93 LTBP4 MN1 NOTCH4

1.77e-051901276cb8798839c27f307955fcc94a1ee40bca95b8e99
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

UNC5B CD109 ZNF521 NEDD4 CD93 NOTCH4

1.77e-051901276a3c6eec6df052105ab78b7e3c78f94218d5912eb
ToppCelldroplet-Kidney-KIDNEY-30m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMCD1 CD109 CD93 LTBP4 MN1 NOTCH4

1.77e-0519012765bf3d0beee69879c95265d07fba023626a7cc808
ToppCellCOPD-Epithelial-Club|COPD / Disease state, Lineage and Cell class

ARHGAP42 MECOM LDLR ZNF608 WFDC2 USP54

1.83e-051911276c909cf5fa0e6519aa93a47d2c3fcd2ae2163cd8d
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

MECOM MALRD1 ZNF608 ATP11A USP54 FBN3

1.83e-051911276d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LMCD1 CD109 MECOM LTBP1 LTBP4 NOTCH4

1.83e-0519112764b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL6A6 GAS1 PAPPA LTBP4 MN1 ARHGAP21

1.88e-0519212768d56e360ebc624ca4cd7f0af4f3cc599c244f134
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

LMCD1 UNC5B CD109 CD93 MN1 NOTCH4

1.88e-05192127627ff3621e177e7932dd44dd6baa81551ea75a874
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MECOM MALRD1 ZNF608 ATP11A USP54 FBN3

1.88e-05192127629f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCelldroplet-Kidney-nan-18m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMCD1 CD109 CD93 LTBP4 MN1 NOTCH4

1.88e-051921276144503af50274eaed5cf6effa892c640eab28663
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL6A6 GAS1 ADGRE2 SCUBE2 PAPPA LTBP4

1.88e-051921276ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCelldroplet-Kidney-nan-18m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMCD1 CD109 CD93 LTBP4 MN1 NOTCH4

1.88e-051921276c96736bb3a6bb052678b1b078f7823063ca69e6d
ToppCellMesenchymal-matrix_fibroblast_2_cell|World / Lineage, Cell type, age group and donor

COL6A6 GAS1 PAPPA LTBP1 LTBP4 MN1

1.88e-051921276a769158c49d2b208c4224d85e7ae68c85cc372ed
DrugOxolinic acid [14698-29-4]; Down 200; 15.4uM; PC3; HT_HG-U133A

APC P3H4 GLG1 ATF7IP2 RNFT1 LRP6 FAM53B ATP11A STAG3

1.60e-0619612792103_DN
Diseaseattempted suicide

DPF1 ELAPOR2 CNST SCUBE2 ATF7IP2 LRP2 CACNA2D3

9.65e-061781227EFO_0004321
Diseaseconnective tissue disease (implicated_via_orthology)

FBN2 FBN3

5.07e-0531222DOID:65 (implicated_via_orthology)
Diseasecreatinine measurement, glomerular filtration rate

EGFEM1P SORT1 LRP2 UMOD C9

1.29e-041171225EFO_0004518, EFO_0005208
Diseasefamilial meningioma (is_implicated_in)

PTEN MN1

2.52e-0461222DOID:4586 (is_implicated_in)
DiseaseMENINGIOMA, FAMILIAL, SUSCEPTIBILITY TO

PTEN MN1

2.52e-0461222607174
DiseaseFamilial meningioma

PTEN MN1

2.52e-0461222cv:C3551915
DiseaseFamilial meningioma

PTEN MN1

2.52e-0461222C1333989
Diseasefatty liver disease (implicated_via_orthology)

PTEN LDLR LRP6

2.85e-04311223DOID:9452 (implicated_via_orthology)
Diseasejoint hypermobility measurement

TUT4 NEDD4 NOTCH4

3.44e-04331223EFO_0007905
Diseasepack-years measurement, systolic blood pressure

MECOM LRP1B LRP2

3.76e-04341223EFO_0006335, EFO_0006526
Diseaseendometrial cancer (is_marker_for)

APC CD59 NOTCH4

4.10e-04351223DOID:1380 (is_marker_for)
DiseaseMalignant neoplasm of breast

FLNA GFRAL UBR4 CD109 MECOM PTEN NEDD4 OTOGL ANKRD30A ZFYVE26 DHX32 USP54 NOTCH4

5.15e-04107412213C0006142
Diseasehemangiopericytoma (is_marker_for)

PTEN NOTCH4

5.99e-0491222DOID:264 (is_marker_for)
DiseaseKunitz-type protease inhibitor 2 measurement

DPF1 RASGRP4

7.47e-04101222EFO_0008200
DiseaseAcute kidney injury

GC LRP2 AHSG ALB

8.34e-041011224C2609414
DiseaseAcute Kidney Insufficiency

GC LRP2 AHSG ALB

8.34e-041011224C1565662
DiseaseKidney Failure, Acute

GC LRP2 AHSG ALB

8.34e-041011224C0022660
Diseasehepatocellular carcinoma (is_implicated_in)

APC GC LRP1B DICER1 ALB

9.55e-041811225DOID:684 (is_implicated_in)
Diseasefamilial hyperlipidemia (implicated_via_orthology)

LDLR ALB

1.09e-03121222DOID:1168 (implicated_via_orthology)
Diseaselower face morphology measurement

CD109 LRP1B CRB1 LTBP1

1.11e-031091224EFO_0010948
DiseaseFulminant Hepatic Failure with Cerebral Edema

GC PRKDC

1.28e-03131222C0751197
DiseaseHepatic Stupor

GC PRKDC

1.28e-03131222C0751198
DiseaseHepatic Encephalopathy

GC PRKDC

1.28e-03131222C0019151
DiseaseHepatic Coma

GC PRKDC

1.28e-03131222C0019147
Diseasegallbladder cancer (is_implicated_in)

APC LRP1B

1.28e-03131222DOID:3121 (is_implicated_in)
DiseaseMetabolic Bone Disorder

GC LRP2

1.49e-03141222C0005944
DiseaseHamman-Rich syndrome

MUC5B ATP11A

1.49e-03141222C0085786
DiseaseRespiratory Distress Syndrome, Adult

APC ALB PROS1

1.55e-03551223C0035222
Diseasememory performance

MECOM GC ALS2 RSPO4 LDLR SCUBE1 CCDC149

1.60e-034091227EFO_0004874
Diseaseoptic disc size measurement

LRP1B LRP2 LTBP1 ADAMTS14 ARHGAP21

1.66e-032051225EFO_0004832
DiseaseOsteopenia

GC LRP2

1.72e-03151222C0029453
Diseaselobe attachment

CHRDL2 GAS1 PRKDC ADAMTS14 MN1

1.73e-032071225EFO_0007667
DiseaseMalignant Neoplasms

APC PTEN DICER1 ENOX2

2.00e-031281224C0006826
DiseaseSarcomatoid Renal Cell Carcinoma

ZNF765 ZNF536 PTEN LRP1B

2.00e-031281224C1266043
DiseaseChromophobe Renal Cell Carcinoma

ZNF765 ZNF536 PTEN LRP1B

2.00e-031281224C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

ZNF765 ZNF536 PTEN LRP1B

2.00e-031281224C1266044
DiseasePapillary Renal Cell Carcinoma

ZNF765 ZNF536 PTEN LRP1B

2.00e-031281224C1306837
DiseaseRenal Cell Carcinoma

ZNF765 ZNF536 PTEN LRP1B

2.00e-031281224C0007134
Diseasecup-to-disc ratio measurement

ARHGAP42 GAS1 ZNF521 RSPO4 GLG1 CCDC171 MN1

2.12e-034301227EFO_0006939
Diseasebody weight

ACP7 ZNF521 MECOM LRP1B CRB1 FBN2 DNAH12 ASXL3 ZNF638 PAPPA LTBP1 ADAMTS14 CCDC171

2.19e-03126112213EFO_0004338
DiseaseLipidemias

APC LDLR

2.21e-03171222C1706412
DiseaseHyperlipidemia

APC LDLR

2.21e-03171222C0020473
Diseaseneuroticism measurement, cognitive function measurement

APC COP1 PCGF3 LRP1B BBX SCUBE2 ASXL3 ZNF638

2.49e-035661228EFO_0007660, EFO_0008354
DiseaseCoronary Arteriosclerosis

LDLR SORT1 PAPPA

2.50e-03651223C0010054
DiseaseCoronary Artery Disease

LDLR SORT1 PAPPA

2.50e-03651223C1956346
Diseaseinterstitial lung disease

MUC5B ATP11A NOTCH4

2.72e-03671223EFO_0004244
DiseaseUsual Interstitial Pneumonia

MUC5B ATP11A

2.77e-03191222C4721509
DiseaseHamman-Rich Disease

MUC5B ATP11A

2.77e-03191222C4721508
Diseaseblood urea nitrogen measurement

TNPO1 GFRAL MECOM LRP2 TMF1 FAM53B CCDC171

2.80e-034521227EFO_0004741
Diseasecortisol measurement

LDLR EGFEM1P

3.07e-03201222EFO_0005843
Diseaseseborrheic dermatitis

ELAPOR2 UNC5B

3.07e-03201222EFO_1000764
DiseaseFamilial Idiopathic Pulmonary Fibrosis

MUC5B ATP11A

3.07e-03201222C4721952
Diseasechin morphology measurement

ZNF536 DICER1 CRB1

3.09e-03701223EFO_0007842
Diseaseanorexia nervosa

CRB1 TRIM33 LRP2

3.09e-03701223MONDO_0005351
Diseasemetabolite measurement, diet measurement

GSX1 LDLR AHSG

3.21e-03711223EFO_0004725, EFO_0008111
Diseasemonocyte count

ARHGAP42 TNPO1 PROK2 RASGRP4 MECOM GC LYST BBX ZNF608 GLG1 PRKDC MN1 NOTCH4

3.25e-03132012213EFO_0005091
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

ZNF765 ZNF536 PTEN LRP1B

3.38e-031481224C0279702
DiseaseIdiopathic Pulmonary Fibrosis

MUC5B ATP11A

3.38e-03211222C1800706
DiseaseNephritis, Tubulointerstitial

UMOD ALB

3.38e-03211222C0041349
Diseasecholangiocarcinoma (is_implicated_in)

APC ALB

3.71e-03221222DOID:4947 (is_implicated_in)
DiseaseSplenomegaly

APC MECOM

3.71e-03221222C0038002
Diseaseremission, hepatitis C virus infection

MALRD1 NOTCH4

4.05e-03231222EFO_0003047, EFO_0009785

Protein segments in the cluster

PeptideGeneStartEntry
DNSVASIEAKANVCC

COP1

546

Q8NHY2
DSESCSAREQECEVK

BACH1

511

O14867
LDEVLEANCCDSAVD

AKAP2

56

Q9Y2D5
IKSNERCCSFDGDAD

PGM3

266

O95394
TCVADESAENCDKSL

ALB

76

P02768
TETDCNDKCSHNTEV

BBX

866

Q8WY36
TTKDACFASAVECLQ

ALS2

1546

Q96Q42
DDINECATLSKVSCG

ADGRE2

66

Q9UHX3
DASNEEKACNELDST

CCDC171

471

Q6TFL3
KSCSLCGTSENDDQL

DPF1

326

Q92782
DDFVIDCCTSLVASD

GVINP1

2326

Q7Z2Y8
ADTACKADDSVVSQD

GZF1

666

Q9H116
HDSSEKCEDINECET

ADGRE4P

46

Q86SQ3
LDSSQLDCVDVDECQ

CD93

336

Q9NPY3
DTESLCETVSQKDVC

ANKRD30A

686

Q9BXX3
LQSQKELCSVTAEDC

AKAP11

31

Q9UKA4
ICKKSAASCSRDEEQ

CD209

376

Q9NNX6
ADCKTAVNCSSDFDA

CD59

36

P13987
AVNCSSDFDACLITK

CD59

41

P13987
EQCIADKSIADCVEA

DICER1

1551

Q9UPY3
SKSILASCEFDCVDE

DHX32

491

Q7L7V1
TADGKNCVDTNECLS

FBN3

1921

Q75N90
ADSSNADELELKCSC

ASXL3

2201

Q9C0F0
DDAQKCELICQSADT

ADAMTS14

641

Q8WXS8
DCLQRDGTTAASCKD

MUC5B

5231

Q9HC84
SDEQVSICLECNSSK

PCGF3

151

Q3KNV8
EKQVICLSGDDSSTC

EDC4

76

Q6P2E9
CEDCDQLFESKAELA

MECOM

211

Q03112
CSNADLDDCTRHESK

ACP7

291

Q6ZNF0
SFCLEDTECQEDVSK

LOXL3

636

P58215
KCSDFCQDDLADDDI

FLII

1181

Q13045
DCGDNSDELDCKVST

LRP1B

2576

Q9NZR2
SDELDCKVSTCATVE

LRP1B

2581

Q9NZR2
DCADASDEANCDKKT

LRP1B

3461

Q9NZR2
ADGSDERNCETSCSK

LRP1B

3541

Q9NZR2
TCNDDSLLDDSCKLT

LRP1B

4206

Q9NZR2
AAAVSCTESDEGAKC

MAGEB1

71

P43366
DCTNELSNSCKTRDD

NEDD4

506

P46934
EKESCASRLCASNQD

ENOX2

501

Q16206
HLACQEDLSCEESDS

FAM53B

366

Q14153
LSAAKDQCEDIDECQ

LTBP1

1111

Q14766
QEKCLAETSVCGATD

PDZD8

881

Q8NEN9
CSEDELLEKCIQSFD

RASGRP4

56

Q8TDF6
CASLSSAKCSEDDDE

GSX1

231

Q9H4S2
LEKICEDFTSETCNS

DNAH12

2566

Q6ZR08
DHNVDCSDKSDELDC

LRP6

1346

O75581
ACSSSEEDDCVSLSK

MTFR1L

221

Q9H019
AKCASNSESDNAACE

MEIKIN

226

A0A087WXM9
EDCDCAQDENCKSTK

GAS1

126

P54826
DGSDEKNCNSTETCQ

LRP2

1136

P98164
LANDSKTCEDIDECD

LRP2

1381

P98164
LANCDISKIGDENCD

PAPPA

411

Q13219
SECRIKCEDSDASQG

PAPPA

1436

Q13219
CQACKDEASEQSDEE

CHRDL2

171

Q6WN34
DCERSCEADILKNTS

DZIP3

256

Q86Y13
CKDDSQFSEEGSSEC

ELAPOR2

326

A8MWY0
KCSQEDHCLTSDLED

LMCD1

51

Q9NZU5
EVNDDQDAILCEASC

PYGO2

336

Q9BRQ0
DAAVITGACDKDSQC

PROK2

26

Q9HC23
EESSCEKGCQVTSEQ

FBXO38

666

Q6PIJ6
CIAKESVCDSRQDCS

MALRD1

446

Q5VYJ5
KLCDFVNDCADNSDE

MALRD1

1281

Q5VYJ5
NTDENECGSSCTFEK

MALRD1

1511

Q5VYJ5
EDELICSNKSCSNGA

MALRD1

1976

Q5VYJ5
QLHCSDEISSLCAEE

GLG1

1006

Q92896
NSEVKLSSCDLCSDV

CD109

1396

Q6YHK3
KQEEDESCAAAEALT

CCDC149

336

Q6ZUS6
TLSKQDLTCSGSDDC

GFRAL

261

Q6UXV0
LDGKCSISCDDETVN

CACNA2D3

841

Q8IZS8
TIKETTGNIACEDCS

CACNA2D3

981

Q8IZS8
CASCEAEDLDALQAA

COLCA2

106

A8K830
TDCVAKEATEAAKCN

AHSG

206

P02765
SKAEISCTDNQDGTC

FLNA

1906

P21333
EKDESLCLSSSCEGA

DDX12P

106

Q92771
SNNCADDILKTDECS

ATF7IP2

241

Q5U623
SEEAEDSQCCSFKLL

LYST

1201

Q99698
EDAFISSCESAKTVC

LYST

2161

Q99698
ACVDINECDEAEAAS

LTBP4

1571

Q8N2S1
RDCKKSTSSQLDCVD

KRTAP16-1

461

A8MUX0
KSDNCAELSEATDDA

CCDC168

2591

Q8NDH2
DGKNCVDHDECTTTN

FBN2

611

P35556
EDCVDINECSLSDNL

FBN2

1196

P35556
KDFSKDNDCSCSDTA

CRB1

46

P82279
DNDCSCSDTANNLDK

CRB1

51

P82279
CVEENTLECSAKNGS

EGFEM1P

71

Q0D2K5
TKMEEASDTCEADCL

SCUBE1

556

Q8IWY4
LTDEKSCQDVDECSL

SCUBE2

356

Q9NQ36
NNESCTLSCEVAAGE

CNST

71

Q6PJW8
DVTASVCNSSKVDCE

COL6A6

981

A6NMZ7
TETNKAEQCCEETAS

C9

246

P02748
YIASCVNDLCKTDDD

OTOGL

341

Q3ZCN5
ENGSLCDQEIDSICS

PTEN

291

P60484
DSELGSCCSEAVKSA

MN1

1196

Q10571
CVAASRCDDKSVENC

PKP1

461

Q13835
GLDVTNCKACDCDTA

USH2A

786

O75445
SECDATAKNKNECSL

SORT1

446

Q99523
EKSEQVCTSCEDNAS

TRIM33

211

Q9UPN9
AEDEVSDNSAECVVC

RNF157

266

Q96PX1
EEAATCQVLSESRKC

RSPO4

176

Q2I0M5
DATKTDAESDCQSVA

ARHGAP42

691

A6NI28
LKSKSCEDIDECSEN

PROS1

236

P07225
SCEENLDDCIAATCA

NOTCH4

351

Q99466
TCSSEGELVCKENDC

BRINP2

281

Q9C0B6
SAHCTENKADICAVD

APC

596

P25054
AASDSECCNINLDTE

CNNM1

891

Q9NRU3
AECCIAANKGTSEQE

CNOT10

396

Q9H9A5
CLCHTVQVKDDDSVD

ATP11A

476

P98196
CEECDEAFSFKSNLE

ZNF845

441

Q96IR2
TQECVSDSECADNLK

WFDC2

46

Q14508
QKLTESCCSSDAFER

TMF1

311

P82094
VAASKRQCSDVDDIC

RNFT1

361

Q5M7Z0
CECDVSEKEFSQTSN

ZNF197

986

O14709
TCEECSIDEDCKSNN

UMOD

296

P07911
SFCVQQAEDCLSEKS

REV3L

1761

O60673
CELCQSCLSDVDTEI

STAG3

781

Q9UJ98
SELESVKENNCASNC

SOBP

766

A7XYQ1
AESLQCKVDCEANLT

P3H4

266

Q92791
CESCDKQFTSVDDLQ

ZNF521

696

Q96K83
EGSDQESEKDNSQCC

ZNF660

21

Q6AZW8
ADGSVSCKRTDCVDS

VWCE

596

Q96DN2
EDITNILSKCCESAS

GC

256

P02774
ILSKCCESASEDCMA

GC

261

P02774
SCINTECIDIEDKSC

ZDBF2

1561

Q9HCK1
KEGSSSQNADSCEIC

ZNF211

101

Q13398
CDVEKDASHSTQITC

PKHD1L1

86

Q86WI1
RDCSGTLLDSKNCTD

UNC5B

336

Q8IZJ1
EAACSAFATLEEEAC

TNPO1

506

Q92973
ADEKSLGTIQQCCDA

PRKDC

1116

P78527
DCLEDIQDADCSSSK

ZBTB1

111

Q9Y2K1
KCTLCDFAASQEEEL

ZNF536

301

O15090
EKCVDVCSDASRAVD

ZBED5

336

Q49AG3
RCLNCETVSSKDEDF

USP46

181

P62068
SCQEEEEFSVLASCL

UBR3

1671

Q6ZT12
ISSADCNCNVIEIDD

ZCCHC18

256

P0CG32
CNCNVIEIDDTLDDS

ZCCHC18

261

P0CG32
SDCEEGLSNVALECS

ZNF608

596

Q9ULD9
CEDCDEAFSFKSNLE

ZNF765

496

Q7L2R6
CKTCEESFALDSELA

ZNF597

371

Q96LX8
ATSCNCKATEDASDL

TUT4

871

Q5TAX3
CKATEDASDLNDDDN

TUT4

876

Q5TAX3
DSQAEDSDEDSLCNK

UBR4

1646

Q5T4S7
DSDEDSLCNKLCTFT

UBR4

1651

Q5T4S7
DVAKSNTAVCVCNES

ARHGAP21

256

Q5T5U3
CQDCKDSLSEDLASA

ZFYVE26

521

Q68DK2
TENCAKEAISDAALE

ZNF638

876

Q14966
IADETKEDICTAQHC

USP54

136

Q70EL1
DCKDKSDEENCAVAT

LDLR

221

P01130