Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP1 LRP6

1.79e-0416252GO:0005041
GeneOntologyMolecularFunctionapolipoprotein binding

LRP1 LRP6

2.82e-0420252GO:0034185
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP1 LRP6

3.11e-0421252GO:0030228
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

MED24 UBE3C KLHL20 TRIM56

2.65e-03473254GO:0004842
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

MED24 UBE3C KLHL20 TRIM56

3.52e-03512254GO:0019787
GeneOntologyMolecularFunctioncoreceptor activity

LRP1 LRP6

3.65e-0372252GO:0015026
GeneOntologyMolecularFunctionaminoacyltransferase activity

MED24 UBE3C KLHL20 TRIM56

4.04e-03532254GO:0016755
GeneOntologyCellularComponentmicrofibril

FBN2 FBN3

9.78e-0513242GO:0001527
DomainFBN

FBN2 FBN3

5.16e-063252IPR011398
DomaincEGF

LRP1 FBN2 FBN3

5.40e-0626253IPR026823
DomaincEGF

LRP1 FBN2 FBN3

5.40e-0626253PF12662
DomainEGF_3

LRP1 LRP6 FBN2 MUC13 FBN3

1.31e-05235255PS50026
DomainEGF

LRP1 LRP6 FBN2 MUC13 FBN3

1.31e-05235255SM00181
DomainEGF-like_dom

LRP1 LRP6 FBN2 MUC13 FBN3

1.73e-05249255IPR000742
Domain-

LRP1 LRP6 TRIM56

1.88e-05392532.120.10.30
DomainEGF_1

LRP1 LRP6 FBN2 MUC13 FBN3

1.94e-05255255PS00022
DomainEGF-like_CS

LRP1 LRP6 FBN2 MUC13 FBN3

2.17e-05261255IPR013032
DomainEGF_2

LRP1 LRP6 FBN2 MUC13 FBN3

2.33e-05265255PS01186
Domain6-blade_b-propeller_TolB-like

LRP1 LRP6 TRIM56

3.10e-0546253IPR011042
DomainTB

FBN2 FBN3

3.60e-057252PF00683
Domain-

FBN2 FBN3

4.79e-0582523.90.290.10
DomainGrowth_fac_rcpt_

LRP1 FBN2 MUC13 FBN3

5.17e-05156254IPR009030
DomainBTB

KCTD9 KLHL5 RHOBTB3 KLHL20

5.70e-05160254PS50097
DomainTB

FBN2 FBN3

6.16e-059252PS51364
DomainTB_dom

FBN2 FBN3

6.16e-059252IPR017878
DomainBTB

KCTD9 KLHL5 RHOBTB3 KLHL20

9.01e-05180254SM00225
DomainBTB/POZ_dom

KCTD9 KLHL5 RHOBTB3 KLHL20

1.00e-04185254IPR000210
DomainSKP1/BTB/POZ

KCTD9 KLHL5 RHOBTB3 KLHL20

1.09e-04189254IPR011333
DomainQuinoprot_gluc/sorb_DH

LRP1 TRIM56

1.13e-0412252IPR011041
DomainLdl_recept_b

LRP1 LRP6

1.55e-0414252PF00058
DomainLDLRB

LRP1 LRP6

1.55e-0414252PS51120
DomainLY

LRP1 LRP6

1.79e-0415252SM00135
DomainLDLR_classB_rpt

LRP1 LRP6

1.79e-0415252IPR000033
DomainEGF_CA

LRP1 FBN2 FBN3

2.01e-0486253PF07645
DomainEGF_Ca-bd_CS

LRP1 FBN2 FBN3

2.87e-0497253IPR018097
DomainEGF_CA

LRP1 FBN2 FBN3

3.05e-0499253PS01187
DomainASX_HYDROXYL

LRP1 FBN2 FBN3

3.14e-04100253PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP1 FBN2 FBN3

3.73e-04106253IPR000152
DomainEGF_CA

LRP1 FBN2 FBN3

5.63e-04122253SM00179
DomainEGF-like_Ca-bd_dom

LRP1 FBN2 FBN3

5.90e-04124253IPR001881
Domain-

KLHL5 KLHL20

5.92e-04272522.130.10.80
DomainEGF

LRP1 LRP6 FBN3

6.19e-04126253PF00008
DomainhEGF

FBN2 FBN3

6.36e-0428252PF12661
DomainBTB

KLHL5 RHOBTB3 KLHL20

6.93e-04131253PF00651
DomainGal_Oxidase_b-propeller

KLHL5 KLHL20

9.40e-0434252IPR015916
DomainLDLR_class-A_CS

LRP1 LRP6

1.30e-0340252IPR023415
DomainLdl_recept_a

LRP1 LRP6

1.64e-0345252PF00057
Domain-

LRP1 LRP6

1.72e-03462524.10.400.10
DomainLDLRA_1

LRP1 LRP6

1.87e-0348252PS01209
DomainLDrepeatLR_classA_rpt

LRP1 LRP6

1.95e-0349252IPR002172
DomainLDLa

LRP1 LRP6

1.95e-0349252SM00192
DomainLDLRA_2

LRP1 LRP6

1.95e-0349252PS50068
DomainKelch

KLHL5 KLHL20

2.72e-0358252SM00612
DomainGal_Oxase/kelch_b-propeller

KLHL5 KLHL20

2.81e-0359252IPR011043
DomainBACK

KLHL5 KLHL20

2.90e-0360252SM00875
DomainBACK

KLHL5 KLHL20

3.00e-0361252PF07707
DomainBACK

KLHL5 KLHL20

3.00e-0361252IPR011705
DomainKelch_1

KLHL5 KLHL20

3.93e-0370252PF01344
DomainKelch_1

KLHL5 KLHL20

3.93e-0370252IPR006652
Pubmed

A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.

KCTD9 KLHL5 RHOBTB3 KLHL20

4.44e-078725437495603
Pubmed

Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk.

LRP1 LRP6

4.96e-07225226031789
Pubmed

The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway.

LRP1 LRP6

2.97e-06425214739301
Pubmed

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FBN2 FBN3

2.97e-06425225034023
Pubmed

Novel CUL3 Variant Causing Familial Hyperkalemic Hypertension Impairs Regulation and Function of Ubiquitin Ligase Activity.

KCTD9 KLHL5 KLHL20

9.36e-065725334878901
Pubmed

Molecular partners of hNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct cellular processes relevant to congenital disorders of glycosylation, cancer, neurodegeneration and a variety of further pathologies.

LRP1 CNOT1

1.04e-05725229547901
Pubmed

Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma.

UBE3C TRIM56

2.72e-051125228963376
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1 LRP6

2.72e-051125224639464
Pubmed

Bone morphogenetic protein (BMP) 7 expression is regulated by the E3 ligase UBE4A in diabetic nephropathy.

UBE3C TRIM56

2.72e-051125230663414
Pubmed

Stage-specific association of apolipoprotein A-I and E in developing mouse retina.

LRP1 LRP6

4.49e-051425217389516
Pubmed

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

LRP1 PKD1L1 DNAI2

5.07e-0510025325807483
Pubmed

A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.

FBN2 TG

6.70e-051725222832960
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

LRP1 LRP6

1.03e-042125221337463
Pubmed

Dimerization quality control ensures neuronal development and survival.

KLHL5 KLHL20

1.36e-042425230190310
Pubmed

Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.

RHOBTB3 KLHL20

1.72e-042725230404837
Pubmed

Update on the Kelch-like (KLHL) gene family.

KLHL5 KLHL20

4.00e-044125223676014
CytobandEnsembl 112 genes in cytogenetic band chr5q23

ARL14EPL FBN2

1.86e-03117252chr5q23
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KCTD9 KLHL5 RHOBTB3 KLHL20

4.90e-06134164861
GeneFamilyLow density lipoprotein receptors

LRP1 LRP6

5.69e-0513162634
GeneFamilyKelch like|BTB domain containing

KLHL5 KLHL20

6.19e-0442162617
ToppCelldroplet-Heart-nan-3m-Endothelial-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF407 KLHL20 CPEB4

9.06e-05157253d85a2f56ae313baa9738e81d2756ce1fe1ba50db
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP6 RHOBTB3 CPEB4

1.21e-041732530c74bdb40e635d906fd180412c23bf7fed61621e
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP1 MCF2 LRRC25

1.25e-041752535a29323d4a848ea544cdd78a0a4b73f9c122dc5e
ToppCelldroplet-Spleen-nan-24m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 MUC13 LRRC25

1.29e-041772535f20a1a875d6f85ec07b097e6afdb07c2f8f88ff
ToppCelldroplet-Spleen-SPLEEN-30m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 MUC13 LRRC25

1.31e-04178253be8af4d85b8835a85a168639c37857dcaa6b00bf
ToppCellfacs-Marrow-KLS-3m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLSCR3 MUC13 RHOBTB3

1.57e-04189253533685a921a65d84107d8d33c43b4fffde019143
ToppCellfacs-Marrow-KLS-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLSCR3 MUC13 RHOBTB3

1.57e-04189253dca56ab02bf0505f9a352ff907edaef30906d854
ToppCellfacs-Marrow-KLS-18m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLSCR3 MUC13 RHOBTB3

1.59e-0419025311f32f46661e44770782b8ec13c00028e1dfc3cd
ToppCellfacs-Marrow-KLS-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLSCR3 MUC13 RHOBTB3

1.59e-04190253a513c1e7df62c28128c932a68b252ee8f0255172
ToppCellfacs-Marrow-KLS-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLSCR3 MUC13 RHOBTB3

1.59e-0419025320f4f6fe09345878484086047061d6f900f9d476
ToppCellfacs-Marrow-KLS-18m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLSCR3 MUC13 RHOBTB3

1.62e-0419125351327ba28b2e3052087fa0fc9b7c0339dc09a1e3
ToppCellfacs-Marrow-KLS-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLSCR3 MUC13 RHOBTB3

1.64e-0419225303dcd9405d3d76fc7455066ba5d83c09cd17072d
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP1 LRRC25 RHOBTB3

1.72e-041952539168267a799bbd4111b1227754ab8173ac1a4714
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP1 FBN2 LRRC25

1.72e-04195253580ed65b4152483b642a7e7dbdf00d03588c46f6
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_monocytic|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP1 FBN2 LRRC25

1.77e-04197253b91016249b3585aa3536e96af18e4f1b1d2d5ce4
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_monocytic-monocyte|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP1 FBN2 LRRC25

1.77e-04197253ec46aa307ce5774b4c0fcba64514f2d0cab3c4f9
ToppCellLPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PKD1L1 CPEB4 DNAI2

1.82e-04199253565404c155dfac57c020a8f2d09cbf756da20ffd
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 FBN2 RHOBTB3

1.82e-0419925384545ced0c792bc77980a50d65e484eab648d47e
ToppCellmLN-(4)_Monocyte|mLN / shred on region, Cell_type, and subtype

LRP1 FBN2 LRRC25

1.82e-041992536795ff31f92580195c9db776951f99d647484d24
ToppCellmLN-Monocyte|mLN / Region, Cell class and subclass

LRP1 FBN2 LRRC25

1.82e-04199253241f790cd5d8a9b2451333deecc826a673bae70a
ToppCellLPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PKD1L1 CPEB4 DNAI2

1.82e-04199253284ee9632413f6404fc0b0c7c393ad813db834f2
ToppCellmLN-(4)_Monocyte-(40)_Monocyte|mLN / shred on region, Cell_type, and subtype

LRP1 FBN2 LRRC25

1.82e-04199253bcbb1eee8d79bf670dbe113094c3a292b135ce2f
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 FBN2 RHOBTB3

1.82e-04199253e78f661b40da34768469549b6e755d330be6bbd8
ToppCellLPS_anti-TNF-Hematopoietic_Erythro-Megakary|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PKD1L1 CPEB4 DNAI2

1.82e-041992536c174dbcc25b980f10a3d1dfe39e613acac73bb6
ToppCellmLN-Monocyte-Monocyte|mLN / Region, Cell class and subclass

LRP1 FBN2 LRRC25

1.82e-04199253dcee372774c169a3048bdaed3734b3215bf8ffad
ToppCellSigmoid-Macrophage-LYVE1_Macrophage|Sigmoid / Region, Cell class and subclass

LRP1 FBN2 LRRC25

1.85e-04200253851a1b372ddbec522829069e69ed36a1f4832131
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 FBN2 RHOBTB3

1.85e-042002533dacd0afe69bc16bb33336ea9ea99a9cd47731d9
ToppCellLPS_IL1RA_TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PKD1L1 CPEB4 DNAI2

1.85e-04200253f100edfd2b3b742458cbbf34de9c403c4d272d3c
ToppCellSigmoid-(6)_Macrophage-(61)_LYVE1_Macrophage|Sigmoid / shred on region, Cell_type, and subtype

LRP1 FBN2 LRRC25

1.85e-04200253bc0280d52e4edc2c5edf4ead164a1c7cf3fccd60
ToppCellcontrol-HLA-DR-_S100A+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LRP1 FBN2 LRRC25

1.85e-04200253107a0665fb20247511a430178effd7630a619488
ToppCellsevere-CD163+_Monocytes_(Sample_ID1_d7)|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LRP1 FBN2 LRRC25

1.85e-042002534943fe826d5fcc3dfeb8b99a7415848f3fecc994
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2|Control_saline / Treatment groups by lineage, cell group, cell type

LRP1 LRP6 FBN2

1.85e-04200253bc8949eb34482aca166c4602ff6ab876cb4c2c3c
DrugSalmfamide 1

FBN2 TG

6.94e-064252CID005487416
Diseaseconnective tissue disease (implicated_via_orthology)

FBN2 FBN3

1.90e-063242DOID:65 (implicated_via_orthology)
Diseasetemperament and character inventory

FBN2 TG

1.73e-0424242EFO_0004825
Diseasepulmonary function measurement, FEV/FEC ratio

LRP1 RHOBTB3

8.52e-0453242EFO_0003892, EFO_0004713
Diseasefeeling miserable measurement

MED24 KLHL20

1.88e-0379242EFO_0009598
Diseasechildhood onset asthma

LRP1 MED24 KLHL5

2.44e-03334243MONDO_0005405
Diseaseobsolete_red blood cell distribution width

ZNF407 FBN2 LRRC25 TRIM56 CPEB4

4.05e-031347245EFO_0005192
Diseasecorneal resistance factor

LRP6 ZNF407 FBN2

5.66e-03451243EFO_0010067

Protein segments in the cluster

PeptideGeneStartEntry
KSGRLICNDADLCDC

ARL14EPL

86

P0DKL9
DCTDVDECALNSLLC

FBN3

721

Q75N90
CDEALFCLRVQDNGC

DNAI2

451

Q9GZS0
AHANLCCANLERADL

KCTD9

251

Q7L273
ARCDLDLQADCNCAL

LRRC25

106

Q8N386
RCVAEALLCNGQDDC

LRP1

2916

Q07954
LGQAAEESNCCARLC

PLSCR3

116

Q9NRY6
NCEVLCLIDQFRCAN

LRP6

1321

O75581
CTNLCAVLFARCLDD

KLHL5

26

Q96PQ7
AADCLCRIINLCENA

HEATR5B

1251

Q9P2D3
CLLQLAEIQEACCEF

KLHL20

146

Q9Y2M5
LQQARQCCDEGECLL

MCF2

331

P10911
QCCDEGECLLANQEI

MCF2

336

P10911
VLDDQLCDECQGARC

CPEB4

661

Q17RY0
CEDINECAQNPLLCA

FBN2

2251

P35556
DDQERCLQAACCLSF

PKD1L1

11

Q8TDX9
VNFRCCRSHDLCNED

PATE1

111

Q8WXA2
NSDLNNLLFCCQCVD

RHOBTB3

241

O94955
ADQRCNCDCTNFLLQ

MED24

351

O75448
AAAQLAQDNCELACC

CNOT1

1491

A5YKK6
DDCLNGLACDCKSDL

MUC13

336

Q9H3R2
LEDCSDCVLAVACQQ

TBCC

246

Q15814
CDLCGFQCSEENLLN

ZNF407

246

Q9C0G0
HLFCLLACDRDLCCD

TG

1721

P01266
ATARCLDCADDLCQA

TRIM56

116

Q9BRZ2
CCRLLQNCNDDSLNV

UBE3C

151

Q15386