Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	I-SMAD binding	TGFBR1 SMAD1 SMAD5 SMAD9	5.46e-07	17	80	4	GO:0070411
GeneOntologyMolecularFunction	retinol binding	RBP7 RBP1 RBP2	3.34e-05	16	80	3	GO:0019841
GeneOntologyMolecularFunction	retinal binding	RBP7 RBP1 RBP2	7.82e-05	21	80	3	GO:0016918
GeneOntologyMolecularFunction	fatty acid binding	RBP7 CYP4F8 RBP1 RBP2	1.69e-04	69	80	4	GO:0005504
GeneOntologyMolecularFunction	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	RDH16 HSD17B6 HSD17B4	3.10e-04	33	80	3	GO:0033764
GeneOntologyMolecularFunction	SMAD binding	TGFBR1 SMAD1 SMAD5 SMAD9	3.95e-04	86	80	4	GO:0046332
GeneOntologyMolecularFunction	androsterone dehydrogenase activity	RDH16 HSD17B6	4.37e-04	8	80	2	GO:0047023
GeneOntologyMolecularFunction	steroid dehydrogenase activity	RDH16 HSD17B6 HSD17B4	5.10e-04	39	80	3	GO:0016229
GeneOntologyMolecularFunction	androstan-3-alpha,17-beta-diol dehydrogenase activity	RDH16 HSD17B6	5.60e-04	9	80	2	GO:0047044
GeneOntologyMolecularFunction	DEAD/H-box RNA helicase binding	SMAD1 SMAD5	5.60e-04	9	80	2	GO:0017151
GeneOntologyMolecularFunction	monocarboxylic acid binding	RBP7 CYP4F8 RBP1 RBP2	9.02e-04	107	80	4	GO:0033293
GeneOntologyMolecularFunction	retinoid binding	RBP7 RBP1 RBP2	9.41e-04	48	80	3	GO:0005501
GeneOntologyMolecularFunction	isoprenoid binding	RBP7 RBP1 RBP2	9.99e-04	49	80	3	GO:0019840
GeneOntologyMolecularFunction	translation regulator activity, nucleic acid binding	TYMS EIF4G1 EIF3A EIF4G3	1.07e-03	112	80	4	GO:0090079
GeneOntologyMolecularFunction	translation initiation factor activity	EIF4G1 EIF3A EIF4G3	1.12e-03	51	80	3	GO:0003743
GeneOntologyMolecularFunction	fucosyltransferase activity	FUT4 POFUT2	1.40e-03	14	80	2	GO:0008417
GeneOntologyMolecularFunction	sodium ion binding	SCN2A SCN8A	1.40e-03	14	80	2	GO:0031402
GeneOntologyBiologicalProcess	positive regulation of voltage-gated calcium channel activity	STAC2 CACNB3 STAC3	4.64e-06	9	80	3	GO:1901387
GeneOntologyCellularComponent	heteromeric SMAD protein complex	SMAD1 SMAD5 SMAD9	2.98e-06	8	80	3	GO:0071144
GeneOntologyCellularComponent	SMAD protein complex	SMAD1 SMAD5 SMAD9	6.35e-06	10	80	3	GO:0071141
GeneOntologyCellularComponent	photoreceptor distal connecting cilium	NPHP1 CEP290	3.00e-04	7	80	2	GO:0120206
GeneOntologyCellularComponent	monoatomic ion channel complex	VWC2 CACNB3 SCN2A STAC3 SCN8A KCNH4 GABRA5	6.12e-04	378	80	7	GO:0034702
HumanPheno	Nystagmus	ESCO2 NPHP1 MPZ SACS SCN2A CEP290 AFG3L2 SCN8A CNKSR2 CHD6 MERTK ROBO3 HSD17B4 THOC2 NCAPG2 GABRA5	2.35e-05	1102	27	16	HP:0000639
HumanPheno	Abnormal involuntary eye movements	ESCO2 NPHP1 MPZ SACS SCN2A CEP290 AFG3L2 SCN8A CNKSR2 CHD6 MERTK ROBO3 HSD17B4 THOC2 NCAPG2 GABRA5	3.02e-05	1123	27	16	HP:0012547
HumanPheno	Abnormal cerebellar peduncle morphology	NPHP1 SACS CEP290	5.79e-05	15	27	3	HP:0011931
HumanPheno	Abnormal brainstem white matter morphology	NPHP1 SACS CEP290	7.10e-05	16	27	3	HP:0012501
HumanPheno	Thickened superior cerebellar peduncle	NPHP1 CEP290	1.61e-04	4	27	2	HP:0002404
HumanPheno	Abnormality of calvarial morphology	ESCO2 NPHP1 TGFBR1 RIPPLY2 CEP290 STAC3 SCN8A CNKSR2 CHD6 ROBO3 HSD17B4 THOC2 NCAPG2 CHST3 GABRA5	1.67e-04	1134	27	15	HP:0002648
HumanPheno	Hammertoe	ESCO2 MPZ SACS HSD17B4	2.04e-04	57	27	4	HP:0001765
HumanPheno	Tremor	NPHP1 MPZ SACS SCN2A AFG3L2 EIF4G1 SCN8A CNKSR2 HSD17B4 THOC2 GABRA5	2.16e-04	639	27	11	HP:0001337
HumanPheno	Neonatal electro-clinical non-motor seizure	SCN2A SCN8A	2.68e-04	5	27	2	HP:0032812
HumanPheno	Neonatal seizure with electrographic correlate	SCN2A SCN8A	2.68e-04	5	27	2	HP:0032808
HumanPheno	Neonatal electro-clinical seizure	SCN2A SCN8A	2.68e-04	5	27	2	HP:0032809
HumanPheno	Neonatal electro-clinical seizure with behavior arrest	SCN2A SCN8A	2.68e-04	5	27	2	HP:0032823
HumanPheno	Focal head nodding automatism seizure	SCN2A SCN8A	2.68e-04	5	27	2	HP:0032906
MousePheno	abnormal vitamin A level	RBP7 RDH16 RBP1 RBP2	3.77e-07	15	59	4	MP:0011232
MousePheno	abnormal retinol level	RDH16 RBP1 RBP2	8.39e-06	10	59	3	MP:0011234
MousePheno	abnormal fat-soluble vitamin level	RBP7 RDH16 RBP1 RBP2	1.70e-05	37	59	4	MP:0005401
MousePheno	neuron degeneration	MPZ LOXHD1 SACS CEP290 AFG3L2 SCN8A MERTK HSD17B4 GABRA5	3.48e-05	391	59	9	MP:0003224
MousePheno	abnormal somatic nervous system morphology	NPHP1 MPZ CACNB3 LOXHD1 CEP290 STAC3 AFG3L2 RBP1 SCN8A MERTK RCC2 SMAD1 NRP2 GABRA5	6.97e-05	1025	59	14	MP:0002752
MousePheno	abnormal vitamin level	RBP7 RDH16 RBP1 RBP2	1.25e-04	61	59	4	MP:0005400
MousePheno	neurodegeneration	MPZ LOXHD1 SACS CEP290 AFG3L2 SCN8A MERTK HSD17B4 GABRA5	1.39e-04	468	59	9	MP:0002229
MousePheno	abnormal nervous system tract morphology	CACNB3 ITSN1 CANX ROBO3 THOC2 NRP2	1.40e-04	189	59	6	MP:0000778
MousePheno	abnormal miniature endplate potential	STAC3 AFG3L2 SCN8A	1.73e-04	26	59	3	MP:0004835
MousePheno	photoreceptor outer segment degeneration	NPHP1 CEP290 MERTK	1.94e-04	27	59	3	MP:0008584
MousePheno	abnormal vitamin homeostasis	RBP7 RDH16 RBP1 RBP2	2.13e-04	70	59	4	MP:0004019
MousePheno	abnormal brain white matter morphology	CACNB3 ITSN1 CANX ROBO3 THOC2 NRP2	2.24e-04	206	59	6	MP:0008026
MousePheno	Purkinje cell degeneration	SACS AFG3L2 SCN8A HSD17B4	3.74e-04	81	59	4	MP:0000876
MousePheno	abnormal PNS synaptic transmission	STAC3 AFG3L2 SCN8A	4.25e-04	35	59	3	MP:0002913
MousePheno	abnormal synaptic physiology	MPZ CACNB3 ITSN1 SCN2A STAC3 AFG3L2 EIF4G1 SCN8A MTMR10 NRP2 CHST3 PNMA8B GABRA5	4.46e-04	1076	59	13	MP:0021009
MousePheno	demyelination	MPZ CANX SCN8A GJC3	4.49e-04	85	59	4	MP:0000921
MousePheno	decreased nerve conduction velocity	MPZ CANX SCN8A	5.42e-04	38	59	3	MP:0008814
MousePheno	abnormal brain commissure morphology	ITSN1 CANX ROBO3 THOC2 NRP2	5.77e-04	161	59	5	MP:0002199
MousePheno	axon degeneration	SACS AFG3L2 SCN8A HSD17B4	5.82e-04	91	59	4	MP:0005405
Domain	SH3	BLK NPHP1 STAC2 CACNB3 ARHGEF19 MYO7B ITSN1 STAC3 NOSTRIN SLA	2.83e-08	216	80	10	SM00326
Domain	SH3	BLK NPHP1 STAC2 CACNB3 ARHGEF19 MYO7B ITSN1 STAC3 NOSTRIN SLA	2.83e-08	216	80	10	PS50002
Domain	SH3_domain	BLK NPHP1 STAC2 CACNB3 ARHGEF19 MYO7B ITSN1 STAC3 NOSTRIN SLA	3.36e-08	220	80	10	IPR001452
Domain	SH3_1	BLK NPHP1 STAC2 ARHGEF19 ITSN1 STAC3 NOSTRIN SLA	5.05e-07	164	80	8	PF00018
Domain	Dwarfin	SMAD1 SMAD5 SMAD9	4.17e-06	8	80	3	IPR013790
Domain	DWB	SMAD1 SMAD5 SMAD9	4.17e-06	8	80	3	SM00524
Domain	MH2	SMAD1 SMAD5 SMAD9	4.17e-06	8	80	3	PS51076
Domain	MH1	SMAD1 SMAD5 SMAD9	4.17e-06	8	80	3	PS51075
Domain	-	SMAD1 SMAD5 SMAD9	4.17e-06	8	80	3	3.90.520.10
Domain	MAD_homology_MH1	SMAD1 SMAD5 SMAD9	4.17e-06	8	80	3	IPR013019
Domain	MH2	SMAD1 SMAD5 SMAD9	4.17e-06	8	80	3	PF03166
Domain	SMAD_dom_Dwarfin-type	SMAD1 SMAD5 SMAD9	4.17e-06	8	80	3	IPR001132
Domain	MAD_homology1_Dwarfin-type	SMAD1 SMAD5 SMAD9	1.62e-05	12	80	3	IPR003619
Domain	DWA	SMAD1 SMAD5 SMAD9	1.62e-05	12	80	3	SM00523
Domain	MH1	SMAD1 SMAD5 SMAD9	1.62e-05	12	80	3	PF03165
Domain	Fatty_acid-bd	RBP7 RBP1 RBP2	4.07e-05	16	80	3	IPR000463
Domain	FABP	RBP7 RBP1 RBP2	4.07e-05	16	80	3	PS00214
Domain	iLBP	RBP7 RBP1 RBP2	4.07e-05	16	80	3	IPR031259
Domain	SMAD_dom-like	SMAD1 SMAD5 SMAD9	4.07e-05	16	80	3	IPR017855
Domain	-	SMAD1 SMAD5 SMAD9	4.07e-05	16	80	3	2.60.200.10
Domain	MA3	EIF4G1 EIF4G3	2.69e-04	6	80	2	SM00544
Domain	Na_trans_cytopl	SCN2A SCN8A	2.69e-04	6	80	2	PF11933
Domain	MA3	EIF4G1 EIF4G3	2.69e-04	6	80	2	PF02847
Domain	MI	EIF4G1 EIF4G3	2.69e-04	6	80	2	PS51366
Domain	Initiation_fac_eIF4g_MI	EIF4G1 EIF4G3	2.69e-04	6	80	2	IPR003891
Domain	Na_trans_cytopl	SCN2A SCN8A	2.69e-04	6	80	2	IPR024583
Domain	SH3_9	STAC2 ARHGEF19 ITSN1 NOSTRIN	3.50e-04	78	80	4	PF14604
Domain	eIF5C	EIF4G1 EIF4G3	3.75e-04	7	80	2	SM00515
Domain	W2	EIF4G1 EIF4G3	3.75e-04	7	80	2	PF02020
Domain	W2	EIF4G1 EIF4G3	3.75e-04	7	80	2	PS51363
Domain	W2_domain	EIF4G1 EIF4G3	3.75e-04	7	80	2	IPR003307
Domain	Lipocln_cytosolic_FA-bd_dom	RBP7 RBP1 RBP2	4.11e-04	34	80	3	IPR000566
Domain	Lipocalin	RBP7 RBP1 RBP2	4.11e-04	34	80	3	PF00061
Domain	-	RBP7 RBP1 RBP2	4.49e-04	35	80	3	2.40.128.20
Domain	Sc_DH/Rdtase_CS	RDH16 HSD17B6 HSD17B4	4.49e-04	35	80	3	IPR020904
Domain	SH3_2	STAC2 MYO7B ITSN1 STAC3	5.08e-04	86	80	4	IPR011511
Domain	SH3_2	STAC2 MYO7B ITSN1 STAC3	5.08e-04	86	80	4	PF07653
Domain	Calycin	RBP7 RBP1 RBP2	5.29e-04	37	80	3	IPR012674
Domain	Calycin-like	RBP7 RBP1 RBP2	5.29e-04	37	80	3	IPR011038
Domain	Na_channel_asu	SCN2A SCN8A	7.97e-04	10	80	2	IPR001696
Domain	MIF4G	EIF4G1 EIF4G3	7.97e-04	10	80	2	SM00543
Domain	Na_trans_assoc	SCN2A SCN8A	7.97e-04	10	80	2	IPR010526
Domain	MIF4G	EIF4G1 EIF4G3	7.97e-04	10	80	2	PF02854
Domain	MIF4G-like_typ-3	EIF4G1 EIF4G3	7.97e-04	10	80	2	IPR003890
Domain	Na_trans_assoc	SCN2A SCN8A	7.97e-04	10	80	2	PF06512
Domain	OTU	YOD1 OTUD7B	1.37e-03	13	80	2	PF02338
Domain	SMAD_FHA_domain	SMAD1 SMAD5 SMAD9	1.44e-03	52	80	3	IPR008984
Domain	ADH_SHORT	RDH16 HSD17B6 HSD17B4	1.52e-03	53	80	3	PS00061
Domain	adh_short	RDH16 HSD17B6 HSD17B4	1.69e-03	55	80	3	PF00106
Domain	SDR_fam	RDH16 HSD17B6 HSD17B4	1.78e-03	56	80	3	IPR002347
Domain	OTU	YOD1 OTUD7B	1.83e-03	15	80	2	PS50802
Domain	MIF4-like	EIF4G1 EIF4G3	1.83e-03	15	80	2	IPR016021
Domain	-	EIF4G1 EIF4G3	1.83e-03	15	80	2	1.25.40.180
Domain	OTU_dom	YOD1 OTUD7B	1.83e-03	15	80	2	IPR003323
Pathway	KEGG_MEDICUS_REFERENCE_MYOSTATIN_SIGNALING_PATHWAY	TGFBR1 SMAD1 SMAD5 SMAD9	2.67e-08	8	64	4	M47847
Pathway	WP_NEOVASCULARIZATION_PROCESSES	TGFBR1 SMAD1 NOTCH4 SMAD5 SMAD9	6.41e-07	37	64	5	M39506
Pathway	BIOCARTA_IRES_PATHWAY	EIF4G1 EIF3A EIF4G3	3.08e-06	7	64	3	M22028
Pathway	KEGG_MEDICUS_REFERENCE_BMP15_SIGNALING_PATHWAY	SMAD1 SMAD5 SMAD9	3.08e-06	7	64	3	M47845
Pathway	PID_ALK1_PATHWAY	TGFBR1 SMAD1 SMAD5 SMAD9	5.36e-06	26	64	4	M185
Pathway	KEGG_MEDICUS_REFERENCE_AMH_SIGNALING_PATHWAY	SMAD1 SMAD5 SMAD9	7.35e-06	9	64	3	M47844
Pathway	KEGG_MEDICUS_REFERENCE_BMP9_10_SIGNALING_PATHWAY	SMAD1 SMAD5 SMAD9	7.35e-06	9	64	3	M47822
Pathway	PID_ALK2_PATHWAY	SMAD1 SMAD5 SMAD9	1.43e-05	11	64	3	M203
Pathway	KEGG_MEDICUS_REFERENCE_BMP_HAMP_SIGNALING_PATHWAY	SMAD1 SMAD5 SMAD9	1.43e-05	11	64	3	M47848
Pathway	WP_BMP2WNT4FOXO1_PATHWAY_IN_PRIMARY_ENDOMETRIAL_STROMAL_CELL_DIFFERENTIATION	SMAD1 SMAD5 SMAD9	2.47e-05	13	64	3	M39378
Pathway	BIOCARTA_EIF_PATHWAY	EIF4G1 EIF3A EIF4G3	4.79e-05	16	64	3	M7721
Pathway	WP_TGFBETA_SIGNALING_PATHWAY	TGFBR1 SMAD1 SMAD5 SMAD9	9.57e-05	53	64	4	MM15880
Pathway	KEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY	SMAD1 SMAD5 SMAD9	9.63e-05	20	64	3	M47843
Pathway	REACTOME_THE_CANONICAL_RETINOID_CYCLE_IN_RODS_TWILIGHT_VISION	RDH16 HSD17B6 RBP1	9.63e-05	20	64	3	MM14888
Pathway	WP_TGFBETA_RECEPTOR_SIGNALING	TGFBR1 SMAD1 SMAD5 SMAD9	1.11e-04	55	64	4	M39351
Pathway	BIOCARTA_MTOR_PATHWAY	EIF4G1 EIF3A EIF4G3	1.29e-04	22	64	3	M16563
Pathway	WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS	TGFBR1 SMAD1 SMAD5 SMAD9	1.46e-04	59	64	4	M39886
Pathway	REACTOME_THE_CANONICAL_RETINOID_CYCLE_IN_RODS_TWILIGHT_VISION	RDH16 HSD17B6 RBP1	1.48e-04	23	64	3	M27174
Pathway	BIOCARTA_CTCF_PATHWAY	TGFBR1 SMAD1 SMAD5	1.69e-04	24	64	3	M11420
Pathway	BIOCARTA_CTCF_PATHWAY	TGFBR1 SMAD1 SMAD5	1.69e-04	24	64	3	MM1373
Pathway	WP_DIFFERENTIATION_OF_WHITE_AND_BROWN_ADIPOCYTE	SMAD1 SMAD5 SMAD9	1.91e-04	25	64	3	M39665
Pathway	BIOCARTA_IRES_PATHWAY	EIF3A EIF4G3	3.01e-04	6	64	2	MM1550
Pathway	REACTOME_SIGNALING_BY_BMP	SMAD1 SMAD5 SMAD9	3.66e-04	31	64	3	M1662
Pathway	REACTOME_SIGNALING_BY_BMP	SMAD1 SMAD5 SMAD9	3.66e-04	31	64	3	MM14789
Pathway	KEGG_TGF_BETA_SIGNALING_PATHWAY	TGFBR1 SMAD1 SMAD5 SMAD9	6.21e-04	86	64	4	M2642
Pathway	BIOCARTA_ALK_PATHWAY	TGFBR1 SMAD1 SMAD5	6.21e-04	37	64	3	M17400
Pathway	REACTOME_VISUAL_PHOTOTRANSDUCTION	RDH16 HSD17B6 RBP1 RBP2	8.00e-04	92	64	4	MM14881
Pathway	PID_BMP_PATHWAY	SMAD1 SMAD5 SMAD9	9.03e-04	42	64	3	M181
Pathway	WP_VITAMIN_A_AND_CAROTENOID_METABOLISM	RBP7 RBP1 RBP2	9.68e-04	43	64	3	M39554
Pathway	WP_RETINOL_METABOLISM	RBP7 RBP1 RBP2	1.03e-03	44	64	3	MM15851
Pathway	REACTOME_VISUAL_PHOTOTRANSDUCTION	RDH16 HSD17B6 RBP1 RBP2	1.09e-03	100	64	4	M27158
Pathway	WP_TRANSLATION_FACTORS	EIF4G1 EIF3A EIF4G3	1.50e-03	50	64	3	M39423
Pathway	REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM	ACSL1 HSD17B4	1.53e-03	13	64	2	MM14821
Pathway	REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM	ACSL1 HSD17B4	1.53e-03	13	64	2	M27114
Pathway	WP_TRANSLATION_FACTORS	EIF4G1 EIF3A EIF4G3	1.59e-03	51	64	3	MM15881
Pathway	WP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES	SMAD1 NOTCH4 SMAD5 SMAD9	2.01e-03	118	64	4	M39852
Pathway	REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS	TGFBR1 SMAD1 SMAD5 SMAD9	2.01e-03	118	64	4	MM15588
Pubmed	ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration.	TGFBR1 SMAD1 SMAD5 SMAD9	4.29e-10	6	82	4	20042635
Pubmed	Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction.	TGFBR1 SMAD1 SMAD5 SMAD9	9.99e-10	7	82	4	15376321
Pubmed	TGF-beta signal transduction.	TGFBR1 SMAD1 SMAD5 SMAD9	3.58e-09	9	82	4	9759503
Pubmed	Altered primordial germ cell migration in the absence of transforming growth factor beta signaling via ALK5.	TGFBR1 SMAD1 SMAD5 SMAD9	3.58e-09	9	82	4	15993878
Pubmed	Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway.	TGFBR1 SMAD1 SMAD5 SMAD9	3.58e-09	9	82	4	14729481
Pubmed	Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor.	TGFBR1 SMAD1 SMAD5 SMAD9	5.96e-09	10	82	4	9436979
Pubmed	Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development.	TGFBR1 SMAD1 SMAD5 SMAD9	9.35e-09	11	82	4	19501582
Pubmed	Non-canonical cyclic AMP SMAD1/5/8 signalling in human granulosa cells.	SMAD1 SMAD5 SMAD9	1.26e-08	3	82	3	30953749
Pubmed	Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys.	SMAD1 SMAD5 SMAD9	1.26e-08	3	82	3	21381028
Pubmed	Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state.	SMAD1 SMAD5 SMAD9	1.26e-08	3	82	3	24023003
Pubmed	Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation.	SMAD1 SMAD5 SMAD9	1.26e-08	3	82	3	27848974
Pubmed	Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.	SMAD1 SMAD5 SMAD9	1.26e-08	3	82	3	31127639
Pubmed	Activated NF-κB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling.	SMAD1 SMAD5 SMAD9	1.26e-08	3	82	3	22897816
Pubmed	TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.	TGFBR1 SMAD1 SMAD5	1.26e-08	3	82	3	19096363
Pubmed	ALK5-mediated transforming growth factor β signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions.	TGFBR1 SMAD1 SMAD5 SMAD9	3.84e-08	15	82	4	24912677
Pubmed	A crucial role of a high mobility group protein HMGA2 in cardiogenesis.	SMAD1 SMAD5 SMAD9	5.04e-08	4	82	3	18425117
Pubmed	Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling.	SMAD1 SMAD5 SMAD9	5.04e-08	4	82	3	23993924
Pubmed	Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.	SMAD1 SMAD5 SMAD9	5.04e-08	4	82	3	17967875
Pubmed	Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin.	SMAD1 SMAD5 SMAD9	5.04e-08	4	82	3	22452883
Pubmed	Characterization of a new member of the fatty acid-binding protein family that binds all-trans-retinol.	RBP7 RBP1 RBP2	5.04e-08	4	82	3	11022035
Pubmed	KMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin.	SMAD1 SMAD5 SMAD9	5.04e-08	4	82	3	25536014
Pubmed	Characterization of new bone morphogenetic protein (Bmp)-2 regulatory alleles.	SMAD1 SMAD5 SMAD9	5.04e-08	4	82	3	28401685
Pubmed	Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells.	SMAD1 SMAD5 SMAD9	5.04e-08	4	82	3	19244313
Pubmed	Signal transduction of bone morphogenetic protein receptors.	SMAD1 SMAD5 SMAD9	5.04e-08	4	82	3	14687659
Pubmed	Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation.	SMAD1 SMAD5 SMAD9	5.04e-08	4	82	3	25755279
Pubmed	Downregulation of Grem1 expression in the distal limb mesoderm is a necessary precondition for phalanx development.	SMAD1 SMAD5 SMAD9	5.04e-08	4	82	3	34719843
Pubmed	Expression levels of endoglin distinctively identify hematopoietic and endothelial progeny at different stages of yolk sac hematopoiesis.	TGFBR1 SMAD1 SMAD5 SMAD9	6.67e-08	17	82	4	23712751
Pubmed	TGF-β-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells.	TGFBR1 SMAD1 SMAD5 SMAD9	8.56e-08	18	82	4	23546880
Pubmed	Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels.	FUT4 SMAD1 SMAD5 SMAD9	8.56e-08	18	82	4	16887830
Pubmed	Betulinic acid synergically enhances BMP2-induced bone formation via stimulating Smad 1/5/8 and p38 pathways.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	27188281
Pubmed	Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	38703029
Pubmed	Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	11121043
Pubmed	Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	20651281
Pubmed	Grainyhead-like 2 interacts with noggin to regulate tissue fusion in mouse.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	38300806
Pubmed	Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	25141865
Pubmed	The TGFβ pathway is a key player for the endothelial-to-hematopoietic transition in the embryonic aorta.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	29253505
Pubmed	Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	27612439
Pubmed	Histone methyltransferase Setdb1 is indispensable for Meckel's cartilage development.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	27890611
Pubmed	The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	21246655
Pubmed	Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	18775991
Pubmed	Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	26735394
Pubmed	FGF-2 enhances Runx-2/Smads nuclear localization in BMP-2 canonical signaling in osteoblasts.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	23559326
Pubmed	Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	15743817
Pubmed	Endoglin is involved in BMP-2-induced osteogenic differentiation of periodontal ligament cells through a pathway independent of Smad-1/5/8 phosphorylation.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	19918795
Pubmed	Self-organized BMP signaling dynamics underlie the development and evolution of digit segmentation patterns in birds and mammals.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	38175868
Pubmed	Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8-mediated signalling.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	10583507
Pubmed	The transcriptional cofactor Jab1/Cops5 is crucial for BMP-mediated mouse chondrocyte differentiation by repressing p53 activity.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	33393086
Pubmed	Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	16813523
Pubmed	Requirement of Oct3/4 function for germ cell specification.	SMAD1 SMAD5 SMAD9	1.26e-07	5	82	3	18395706
Pubmed	Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain.	TGFBR1 SMAD1 SMAD5 SMAD9	1.67e-07	21	82	4	25406396
Pubmed	The cortical hem regulates the size and patterning of neocortex.	SMAD1 SMAD5 NRP2 SMAD9	2.03e-07	22	82	4	24948604
Pubmed	Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.	FUT4 SMAD1 SMAD5 SMAD9	2.46e-07	23	82	4	29981310
Pubmed	Smad7 is required for the development and function of the heart.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	18952608
Pubmed	PDGF-AA promotes osteogenic differentiation and migration of mesenchymal stem cell by down-regulating PDGFRα and derepressing BMP-Smad1/5/8 signaling.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	25470749
Pubmed	BMP/SMAD signaling regulates the cell behaviors that drive the initial dorsal-specific regional morphogenesis of the otocyst.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	20837004
Pubmed	Lack of the bone morphogenetic protein BMP6 induces massive iron overload.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	19252488
Pubmed	BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	28576771
Pubmed	Development of bat flight: morphologic and molecular evolution of bat wing digits.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	16618938
Pubmed	Mesenchymal bone morphogenetic protein signaling is required for normal pancreas development.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	20522595
Pubmed	Quantitative analysis of signaling responses during mouse primordial germ cell specification.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	34184730
Pubmed	Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	21518886
Pubmed	Hypoxia and Reactive Oxygen Species Homeostasis in Mesenchymal Progenitor Cells Define a Molecular Mechanism for Fracture Nonunion.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	27250101
Pubmed	BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	33436697
Pubmed	Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	11850197
Pubmed	Vertebrate crossveinless 2 is secreted and acts as an extracellular modulator of the BMP signaling cascade.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	15188429
Pubmed	BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	19269967
Pubmed	SMAD expression in the testis: an insight into BMP regulation of spermatogenesis.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	18069690
Pubmed	The dorsal aorta initiates a molecular cascade that instructs sympatho-adrenal specification.	SMAD1 SMAD5 SMAD9	2.51e-07	6	82	3	22723422
Pubmed	Fstl1 antagonizes BMP signaling and regulates ureter development.	TGFBR1 SMAD1 SMAD5 SMAD9	3.50e-07	25	82	4	22485132
Pubmed	Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals.	ROBO3 SMAD1 SMAD5 SMAD9	3.50e-07	25	82	4	36067211
Pubmed	The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage.	TGFBR1 SMAD1 SMAD5 SMAD9	4.12e-07	26	82	4	31311865
Pubmed	BMPER-induced BMP signaling promotes coronary artery remodeling.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	24373957
Pubmed	Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	15009097
Pubmed	Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	20807528
Pubmed	Emergence of dorsal-ventral polarity in ESC-derived retinal tissue.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	27633992
Pubmed	Heparan sulfate deficiency in periocular mesenchyme causes microphthalmia and ciliary body dysgenesis.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	19782070
Pubmed	Noggin is required for early development of murine upper incisors.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	22302143
Pubmed	Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	25758226
Pubmed	Fibroblast growth factor 2 inhibits bone morphogenetic protein 9-induced osteogenic differentiation of mesenchymal stem cells by repressing Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	23680673
Pubmed	Genetic interaction between Bmp2 and Bmp4 reveals shared functions during multiple aspects of mouse organogenesis.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	19116164
Pubmed	Cnn3 regulates neural tube morphogenesis and neuronal stem cell properties.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	29151265
Pubmed	Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	16624858
Pubmed	HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1/5/8, ERK and p38 phosphorylation.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	24269886
Pubmed	Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling.	TGFBR1 SMAD1 SMAD5	4.39e-07	7	82	3	14580334
Pubmed	Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	18322278
Pubmed	Cessation of gastrulation is mediated by suppression of epithelial-mesenchymal transition at the ventral ectodermal ridge.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	18003744
Pubmed	Negative regulation of BMP/Smad signaling by Tob in osteoblasts.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	11163184
Pubmed	Role of smad- and wnt-dependent pathways in embryonic cardiac development.	SMAD1 SMAD5 SMAD9	4.39e-07	7	82	3	16522160
Pubmed	Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.	TGFBR1 SMAD1 SMAD5	4.39e-07	7	82	3	9748228
Pubmed	Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.	TGFBR1 SMAD1 NOTCH4 SMAD5	4.83e-07	27	82	4	35894043
Pubmed	A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension.	SMAD1 SMAD5 SMAD9	7.01e-07	8	82	3	19211612
Pubmed	Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.	SMAD1 SMAD5 SMAD9	7.01e-07	8	82	3	10647776
Pubmed	Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a.	SMAD1 SMAD5 SMAD9	7.01e-07	8	82	3	29126155
Pubmed	Loss of peri-Wolffian duct stromal Frs2α expression in mice leads to abnormal ureteric bud induction and vesicoureteral reflux.	SMAD1 SMAD5 SMAD9	7.01e-07	8	82	3	29135976
Pubmed	Follistatin like-1 (Fstl1) is required for the normal formation of lung airway and vascular smooth muscle at birth.	SMAD1 SMAD5 SMAD9	7.01e-07	8	82	3	28574994
Pubmed	Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network.	SMAD1 SMAD5 SMAD9	7.01e-07	8	82	3	23804438
Pubmed	BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.	SMAD1 SMAD5 SMAD9	7.01e-07	8	82	3	17301089
Pubmed	Sox9 drives columnar differentiation of esophageal squamous epithelium: a possible role in the pathogenesis of Barrett's esophagus.	SMAD1 SMAD5 SMAD9	7.01e-07	8	82	3	23064761
Pubmed	Bmp signaling is required for development of primary lens fiber cells.	SMAD1 SMAD5 SMAD9	7.01e-07	8	82	3	12117821
Pubmed	Bmp7 functions via a polarity mechanism to promote cloacal septation.	SMAD1 SMAD5 SMAD9	7.01e-07	8	82	3	22253716
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	CACNB3 DNAJC14 RDH16 HSD17B6 STAC3 SCN8A	1.15e-04	423	82	6	chr12q13
Cytoband	1p36.13	ARHGEF19 RCC2 PADI1	1.42e-04	56	82	3	1p36.13
Cytoband	12q13	CACNB3 HSD17B6 SCN8A	2.88e-04	71	82	3	12q13
GeneFamily	SMAD family	SMAD1 SMAD5 SMAD9	1.92e-06	8	60	3	750
GeneFamily	Fatty acid binding protein family	RBP7 RBP1 RBP2	1.89e-05	16	60	3	550
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN2A SCN8A	3.84e-04	9	60	2	1203
GeneFamily	Fucosyltransferases\|Blood group antigens	FUT4 POFUT2	8.25e-04	13	60	2	434
GeneFamily	OTU domain containing	YOD1 OTUD7B	1.43e-03	17	60	2	669
GeneFamily	Short chain dehydrogenase/reductase superfamily	RDH16 HSD17B6 HSD17B4	2.06e-03	76	60	3	743
Coexpression	GSE17186_MEMORY_VS_NAIVE_BCELL_DN	ACSL1 TGFBR1 EML5 CEP290 NOSTRIN SLA SMAD1	3.18e-06	200	82	7	M7171
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ARL4C STAC2 EML5 PUM2 EIF4G3 SLA	3.39e-07	149	82	6	6e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RBP7 NOSTRIN CRISPLD1 KCNH4 NOTCH4 SMAD9	7.10e-07	169	82	6	0d8b681404e18f3061d84425fb5f7d84e8e2b8d7
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RBP7 RDH16 SCN2A RBP2 SMAD1 NRP2	1.41e-06	190	82	6	e80d66ba0d5c263e94c1ab0b89d1dc7b837af3e1
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RBP7 RDH16 SCN2A RBP2 SMAD1 NRP2	1.41e-06	190	82	6	f32d66c0e74e0a2a23ecb857c4daf0d8573a806c
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RBP7 RDH16 SCN2A RBP2 SMAD1 NRP2	1.41e-06	190	82	6	b79ffd05806244a9790cd04c66fb4f92c824e69f
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B SCN8A CNKSR2 SMAD9 CFAP65	5.50e-06	137	82	5	4dcb15de821439011df1bb0bbd7682d674bd725d
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B SCN8A CNKSR2 SMAD9 CFAP65	5.50e-06	137	82	5	c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ITSN1 MERTK NOTCH4 SMAD5 NRP2	1.07e-05	157	82	5	432b8719a8afd289cf48068e12c26a349d753fcc
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ESCO2 TYMS RBP7 NOSTRIN NOTCH4	1.48e-05	168	82	5	37249f38f8f04ec5743097259de67b106ca2b02f
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DNAJC14 ITSN1 SCN8A MRPS5 NRP2	1.85e-05	176	82	5	e08e7a6dd0208acfbb8646d71915af822a64b5de
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DNAJC14 ITSN1 SCN8A MRPS5 NRP2	1.85e-05	176	82	5	b8264cdda75c5145d8bf8ae00b3e05393fe9a92b
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DNAJC14 ITSN1 SCN8A MRPS5 NRP2	1.85e-05	176	82	5	4aee9fdada077db7e531684ab938153f84dc8146
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RBP7 NOSTRIN KCNH4 NOTCH4 SMAD9	1.90e-05	177	82	5	fdf2af00fc971f0cd3915e1416e4a256458d6ea8
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RBP7 NOSTRIN KCNH4 NOTCH4 SMAD9	1.90e-05	177	82	5	12f8627124acbf436e75681ff1ce429ff5e3f256
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ESCO2 TYMS RBP7 NOSTRIN NOTCH4	2.29e-05	184	82	5	fa38d6a8709f520a027ad7e3ff783c84187ec467
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXHD1 MYO7B SCN2A CNKSR2 SLC4A4	2.29e-05	184	82	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LOXHD1 RIPPLY2 RBP1 SMAD1 NRP2	2.29e-05	184	82	5	30ca56d64c961127e26122613e35aa2b46fde2df
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXHD1 MYO7B SCN2A CNKSR2 SLC4A4	2.29e-05	184	82	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXHD1 MYO7B SCN2A CNKSR2 SLC4A4	2.29e-05	184	82	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Tongue-nan-24m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL1 RBP7 RBP1 RBP2 PADI1	2.41e-05	186	82	5	18c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCell	droplet-Lung-nan-18m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBP7 RDH16 RBP2 SMAD1 NRP2	2.54e-05	188	82	5	a6ed43fdd42d681c9fbb2fb368947ab7e41d8d7c
ToppCell	droplet-Lung-nan-18m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBP7 RDH16 RBP2 SMAD1 NRP2	2.54e-05	188	82	5	54550313db78b3b5b572fa1e67092c8f6f33aab5
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL1 RBP7 RBP1 RBP2 PADI1	2.81e-05	192	82	5	c7185fbc56ffd4c62db47fc240b3207ef65db40e
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL1 RBP7 RBP1 RBP2 PADI1	2.88e-05	193	82	5	55eab7d2574e9cc2ed8f08e0a7ca7cbf90fb5818
ToppCell	droplet-Lung-nan-21m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPZ VWC2 RBP1 CNKSR2 CRISPLD1	2.95e-05	194	82	5	95dfbd9d9b8a47801edcfc35fb0d685901dcd2f8
ToppCell	droplet-Lung-nan-21m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPZ VWC2 RBP1 CNKSR2 CRISPLD1	2.95e-05	194	82	5	2507f6dc7f1fe8b91fe1e24497d26d05afc3cd21
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ACSL1 ITSN1 MERTK SLA NRP2	2.95e-05	194	82	5	45708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ACSL1 ITSN1 MERTK SLA NRP2	3.02e-05	195	82	5	247803cf58c6d9c561a52aa34e581188ddad197e
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ACSL1 ARL4C MERTK SLA NRP2	3.02e-05	195	82	5	312d9625655b38f1a7c2bf8f8bb7b667ebdf9617
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RBP7 CANX EIF4G1 EIF3A HSD17B4	3.10e-05	196	82	5	28e9e191361966df3a9bd48450090577aa72a999
ToppCell	droplet-Tongue-nan-3m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL1 RBP7 RBP1 RBP2 PADI1	3.10e-05	196	82	5	159061fd0961b2cfb5941d403acc5b395dd0d3a0
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ESCO2 TYMS MYO7B STAC3 NCAPG2	3.33e-05	199	82	5	c6d59ed26eadd3c41acfe1b4d929270e00ea3e95
ToppCell	Severe-Developping_Plasmablast\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ESCO2 TYMS CANX EIF4G1 NCAPG2	3.41e-05	200	82	5	6d0cd00e52568d23597cc2a4059bd967d7d2dab5
ToppCell	Severe-Developping_Plasmablast\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ESCO2 TYMS CANX EIF4G1 NCAPG2	3.41e-05	200	82	5	80639e0d2ddaae36ac7634a4f03e8809af7316e3
ToppCell	PND07-28-samps-Lymphocyte-B_cell-B_cell_2\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	BLK VWC2 PRSS42P CHST3	1.20e-04	137	82	4	2544d1256f11da6e3bad24a871b2253e0ab20d01
ToppCell	PND07-28-samps-Lymphocyte-B_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	BLK VWC2 PRSS42P CHST3	1.20e-04	137	82	4	874e2eaa7846a2832f46b77c726d79f220a4a1cd
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	LOXHD1 CNKSR2 ROBO3 GABRA5	1.57e-04	147	82	4	8f725ff8fb4ced5db2643e80669d3f7945b820ab
ToppCell	COVID-19-Mast_cells-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	VWC2 SCN2A FUT4 MTMR10	1.70e-04	150	82	4	10697c2d22cb25376827cc7c570ff1adc94c1acd
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BLK STAC2 APEX1 CHST3	1.70e-04	150	82	4	d6b977dd47aa017f6ba762f0c505cd896caa523f
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related-Oligodendrocyte/OPC\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	MPZ ARL4C STAC3 RBP2	1.74e-04	151	82	4	4533bccc996395f74b16af939ce79b6fe253c073
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	MPZ ARL4C STAC3 RBP2	1.74e-04	151	82	4	edb2f59789c295838d2030b80c792cbea25eaa3d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TGFBR1 SCN2A SLC4A4 CRISPLD1	1.74e-04	151	82	4	f4f7156b2c0cfc78fd1841e07c9915d97ced561f
ToppCell	PND07-Endothelial-Endothelial_lymphatic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RBP7 ROBO3 SMAD1 NRP2	2.22e-04	161	82	4	133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RBP7 ROBO3 SMAD1 NRP2	2.22e-04	161	82	4	9466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TYMS RBP7 CRISPLD1 NCAPG2	2.22e-04	161	82	4	f4f5d6eaa32169de699c8ff8e8ae35179c8e25c0
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RBP7 ROBO3 SMAD1 NRP2	2.22e-04	161	82	4	cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RBP7 NOSTRIN NOTCH4 SMAD9	2.33e-04	163	82	4	73c03e29a6d7a6863c5e9aa5e8b963ef691f1ddb
ToppCell	facs-Liver-Non-hepatocytes-24m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLK LOXHD1 IL36B CHST3	2.39e-04	164	82	4	07d9252b267cb61c6050fbfa5b440aef1349f673
ToppCell	facs-Liver-Non-hepatocytes-24m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLK LOXHD1 IL36B CHST3	2.39e-04	164	82	4	7c016236f0cea38195c1373ebbd2c0b2b2ec81ad
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TYMS YOD1 LOXHD1 NCAPG2	2.39e-04	164	82	4	5621c2e3fae84d5a2e4f1595e454bcb3a2b3f93c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IL36B NOSTRIN KCNH4 NOTCH4	2.44e-04	165	82	4	6a621b300442c52adfc15b61d3a6d3a3cb00099f
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RBP7 NCAPG2 SMAD1 NRP2	2.44e-04	165	82	4	50a8513d8d2630861499393a7f102b35366bad37
ToppCell	Dividing_Macrophages-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	ESCO2 MYO7B APEX1 NCAPG2	2.50e-04	166	82	4	c503036f3c19ef186e1e62c9643c49dea3827f51
ToppCell	droplet-Fat-SCAT-30m-Lymphocytic-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLK MPZ SLA CHST3	2.50e-04	166	82	4	67370c49d7aedcb4eca802095f06b30f6bbf8919
ToppCell	droplet-Fat-SCAT-30m-Lymphocytic\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLK MPZ SLA CHST3	2.50e-04	166	82	4	7f4e5976ede6478636aa567d6fc2b56ff7295fb8
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RDH16 ROBO3 SMAD1 NRP2	2.67e-04	169	82	4	f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCell	droplet-Spleen-nan-21m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBR1 ROBO3 PADI1 PNMA8B	2.67e-04	169	82	4	7962165cab84af73d20b56eb70b1ed87c94025ef
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ESCO2 TYMS SCN2A NCAPG2	2.67e-04	169	82	4	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TYMS RDH16 SMAD1 NRP2	2.74e-04	170	82	4	35e3945d8a540a3e2cec1b559316265aaad023d1
ToppCell	PND01-Endothelial-Endothelial_lymphatic\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TYMS RDH16 SMAD1 NRP2	2.74e-04	170	82	4	0ea625abaa25bab93b70b7000e8f90d5c0f9a0fb
ToppCell	NS-critical-d_0-4-Myeloid-Monocyte-derived_Macrophage\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ZSWIM9 DNAJC14 MYO7B PADI1	2.74e-04	170	82	4	adf73bdc049d508f8873c22539db2ca92052a97b
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TYMS RDH16 SMAD1 NRP2	2.74e-04	170	82	4	0b5ddc7d452db0a389927a367914f7d257703f7e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TYMS NCAPG2 KCNH4 NRP2	2.92e-04	173	82	4	9f892d756d05e573af018db64edb130ff187ad47
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESCO2 TYMS NOSTRIN NCAPG2	2.99e-04	174	82	4	66555c610251ea04f968c258e312d720c18e7cde
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPZ CNKSR2 GJC3 MERTK	3.05e-04	175	82	4	c36b4526970db9ccfbe2c70b00961fab9f13b133
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBP7 RBP2 SMAD1 NRP2	3.05e-04	175	82	4	9d082ba0e350162aa6e71b668be074b12a27c7ab
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWC2 SACS SCN8A CRISPLD1	3.05e-04	175	82	4	a5db428b078938627e61b7e944c1e0c1d61ac2da
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBP7 RBP2 SMAD1 NRP2	3.05e-04	175	82	4	f641f34b52aec5d047430a6f9d026e915da6c11d
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWC2 SACS SCN8A CRISPLD1	3.05e-04	175	82	4	8b498eea1ec1c1f27b171025c3d08adf3687bafc
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPZ CNKSR2 GJC3 MERTK	3.05e-04	175	82	4	c1e082538f31b5c98ac63f71dcca4a1211a14708
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESCO2 TYMS RBP1 PRSS42P	3.05e-04	175	82	4	a154b28b0b2180652d51d4c7d804b3b81b35899e
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPZ CNKSR2 GJC3 MERTK	3.05e-04	175	82	4	2f9b5bdf8a62e8e99d1c4f677a8e5525bfd3b4ce
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RBP7 RDH16 NOTCH4 PNMA8B	3.12e-04	176	82	4	1df7b6ce2519ad99bacbbaf1a8d5929e11513faa
ToppCell	facs-Skin-Anagen-3m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLK SACS SLC4A4 SLA	3.19e-04	177	82	4	7853430fb0d1a18d835e8956777e0616c5d7d412
ToppCell	wk_15-18-Epithelial-PNS-Schwann_precursor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TYMS MPZ SACS SCN8A	3.19e-04	177	82	4	5357359e6c2161a37f39a6b3b78449f5cbc327d1
ToppCell	NS-moderate-d_0-4-Lymphoid-NKT-proliferating\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ESCO2 TYMS VWC2 SCN8A	3.19e-04	177	82	4	174c54acfe19e2bb31418d69e228032ba724cbb6
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EML5 SCN2A SCN8A CNKSR2	3.19e-04	177	82	4	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RBP7 RBP1 CRISPLD1 NRP2	3.19e-04	177	82	4	6f6cf93893daac6ae228df36219ee3acf8de8f97
ToppCell	facs-Skin-Anagen-3m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLK SACS SLC4A4 SLA	3.19e-04	177	82	4	395f005f019aabb18738d3a10a04c37f216deda3
ToppCell	facs-Skin-Anagen-3m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLK SACS SLC4A4 SLA	3.19e-04	177	82	4	9a5bf67a801826d094f679dd2189b62296c9694f
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ESCO2 TYMS NCAPG2 NRP2	3.19e-04	177	82	4	73ba0f0b4b33f10e9f036d6d9befa48a1258e682
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ESCO2 TYMS RBP7 NOTCH4	3.26e-04	178	82	4	462111b61f37338f97ac7dc6c7da1d4316b54445
ToppCell	droplet-Bladder-nan-24m-Epithelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPZ SACS RBP1 CHST3	3.33e-04	179	82	4	dfd9d29281510d32f1a2e8336d2e58ef496cfd1d
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESCO2 TYMS ARL4C NCAPG2	3.33e-04	179	82	4	54191c00b29f53b520cd3243b5791daa4a2c72d7
ToppCell	NS-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	STAC2 RBP1 CHST3 SMAD9	3.33e-04	179	82	4	65a96bee7bc28f5bfc20f0fd92bcc0ab2eb5e06c
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESCO2 TYMS ARL4C NCAPG2	3.40e-04	180	82	4	5e1680088065be14447d5d5465f91f7edd071a1e
ToppCell	NS\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BLK RBP1 GJC3 PADI1	3.40e-04	180	82	4	8472dcce7bc0b7ce428ec17ddf0018f3258f78d2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ESCO2 TYMS SCN2A NCAPG2	3.40e-04	180	82	4	401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VWC2 ARHGEF19 RBP1 PNMA8B	3.40e-04	180	82	4	e9785ac2806103f725f5a5208495826354ec6e22
ToppCell	P15-Endothelial-proliferative_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ESCO2 TYMS ARL4C NCAPG2	3.47e-04	181	82	4	0c5bc1660b8fc1e905ab4230202862de5be46ebd
ToppCell	P28-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ESCO2 TYMS ARL4C NCAPG2	3.47e-04	181	82	4	e482fd116c00ff4d8db7be3c06b1bd1ffa2d479d
ToppCell	P15-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ESCO2 TYMS ARL4C NCAPG2	3.47e-04	181	82	4	f83565f09dd971c5cad2704a4a86bca0accd955e
ToppCell	P28-Endothelial-proliferative_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ESCO2 TYMS ARL4C NCAPG2	3.47e-04	181	82	4	2be3d44619adb25d339e7a27b500a56e07e8de01
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBP7 SLC4A4 CRISPLD1 KCNH4	3.62e-04	183	82	4	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	Control-T/NK_proliferative\|Control / Disease group and Cell class	TYMS RBP7 NOSTRIN NCAPG2	3.62e-04	183	82	4	09c2b4e630f1c338f02c1242e3598e870d6b0a28
ToppCell	Cerebellum-Macroglia\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ARHGEF19 ANKUB1 GJC3 MTMR10	3.69e-04	184	82	4	91b047a01d2cad231308279ca37fa699630f7864
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CYP4F8 NOSTRIN NOTCH4 SMAD9	3.69e-04	184	82	4	688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCell	3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RBP7 NOSTRIN ROBO3 NOTCH4	3.69e-04	184	82	4	842473fa415575441b595073a994b6d621169776
ToppCell	Frontal_cortex-Neuronal-Excitatory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SCN2A CNKSR2 GABRA5 CFAP65	3.69e-04	184	82	4	6e17c8151d6dc543de16d804db956c63c3fda414
ToppCell	droplet-Mammary_Gland-nan-18m-Lymphocytic-B_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLK ANKUB1 SLA CHST3	3.69e-04	184	82	4	73ddf9d647d61381bab1e9c0d983736b6d390c15
Drug	palinavir	EIF4G1 EIF3A EIF4G3	1.56e-06	7	82	3	CID000072981
Drug	5-methoxypsoralen	SMAD1 SMAD5 SMAD9	1.56e-06	7	82	3	ctd:C022909
Drug	LDN 193189	SMAD1 SMAD5 SMAD9	2.49e-06	8	82	3	ctd:C554430
Drug	Ro 12-4825	RBP7 RBP1 RBP2	1.25e-05	13	82	3	CID006441098
Disease	juvenile polyposis syndrome (implicated_via_orthology)	SMAD1 SMAD5 SMAD9	4.80e-06	13	77	3	DOID:0050787 (implicated_via_orthology)
Disease	Benign familial infantile epilepsy	SCN2A SCN8A	2.01e-05	3	77	2	cv:C5575231
Disease	beta-hydroxybutyric acid measurement	NOSTRIN MERTK	1.00e-04	6	77	2	EFO_0010465
Disease	Familial benign neonatal epilepsy	SCN2A SCN8A	1.00e-04	6	77	2	C0220669
Disease	Renal dysplasia and retinal aplasia	NPHP1 CEP290	1.40e-04	7	77	2	cv:C0403553
Disease	Senior-Loken syndrome (is_implicated_in)	NPHP1 CEP290	1.40e-04	7	77	2	DOID:0050576 (is_implicated_in)
Disease	Idiopathic pulmonary hypertension	SMAD1 SMAD9	2.39e-04	9	77	2	C0152171
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN2A SCN8A	2.98e-04	10	77	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN2A SCN8A	2.98e-04	10	77	2	DOID:0080422 (implicated_via_orthology)
Disease	Renal dysplasia and retinal aplasia (disorder)	NPHP1 CEP290	4.36e-04	12	77	2	C0403553
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN2A SCN8A	4.36e-04	12	77	2	DOID:0060170 (implicated_via_orthology)
Disease	Bardet-Biedl Syndrome	NPHP1 CEP290	5.15e-04	13	77	2	C0752166
Disease	2-oxo-hept-3-ene-1,7-dioate hydratase activity	SMAD1 SMAD9	5.99e-04	14	77	2	C1150929
Disease	Idiopathic pulmonary arterial hypertension	SMAD1 SMAD9	7.88e-04	16	77	2	C3203102
Disease	Familial primary pulmonary hypertension	SMAD1 SMAD9	8.91e-04	17	77	2	C0340543
Disease	Familial Progressive Myoclonic Epilepsy	SACS AFG3L2	8.91e-04	17	77	2	C0751777
Disease	Atypical Inclusion-Body Disease	SACS AFG3L2	8.91e-04	17	77	2	C0751776
Disease	Myoclonic Epilepsies, Progressive	SACS AFG3L2	8.91e-04	17	77	2	C0751778
Disease	Biotin-Responsive Encephalopathy	SACS AFG3L2	8.91e-04	17	77	2	C0751780
Disease	May-White Syndrome	SACS AFG3L2	8.91e-04	17	77	2	C0751782
Disease	Dentatorubral-Pallidoluysian Atrophy	SACS AFG3L2	8.91e-04	17	77	2	C0751781
Disease	Action Myoclonus-Renal Failure Syndrome	SACS AFG3L2	1.00e-03	18	77	2	C0751779
Disease	Familial aplasia of the vermis	NPHP1 CEP290	1.24e-03	20	77	2	cv:C0431399
Disease	Leber Congenital Amaurosis	CEP290 MERTK	1.50e-03	22	77	2	C0339527
Disease	West Syndrome	SCN2A HSD17B4	1.79e-03	24	77	2	C0037769
Disease	Adenocarcinoma of lung (disorder)	TYMS APEX1 MRPS5 SLC4A4	2.10e-03	206	77	4	C0152013
Disease	Visual seizure	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0270824
Disease	Epileptic drop attack	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0270846
Disease	Generalized seizures	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0234533
Disease	Clonic Seizures	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0234535
Disease	Vertiginous seizure	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0422855
Disease	Gustatory seizure	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0422854
Disease	Seizures, Somatosensory	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0422850
Disease	Olfactory seizure	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0422853
Disease	Seizures, Auditory	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0422852
Disease	Generalized Absence Seizures	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C4505436
Disease	Convulsive Seizures	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0751494
Disease	Seizures, Sensory	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0751496
Disease	Jacksonian Seizure	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0022333
Disease	Non-epileptic convulsion	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0751056
Disease	Atonic Absence Seizures	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0751123
Disease	Complex partial seizures	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0149958
Disease	Single Seizure	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C0751110
Disease	Epileptic Seizures	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C4317109
Disease	Nonepileptic Seizures	APEX1 NRP2 GABRA5	2.37e-03	101	77	3	C3495874
Disease	Colorectal Carcinoma	TYMS TGFBR1 SACS EIF4G1 CNKSR2 KCNH4 SMAD9	2.38e-03	702	77	7	C0009402
Disease	Tonic Seizures	APEX1 NRP2 GABRA5	2.44e-03	102	77	3	C0270844
Disease	Absence Seizures	APEX1 NRP2 GABRA5	2.44e-03	102	77	3	C4316903
Disease	Convulsions	APEX1 NRP2 GABRA5	2.44e-03	102	77	3	C4048158
Disease	Seizures, Focal	APEX1 NRP2 GABRA5	2.58e-03	104	77	3	C0751495
Disease	Myoclonic Seizures	APEX1 NRP2 GABRA5	2.58e-03	104	77	3	C4317123
Disease	Tonic - clonic seizures	APEX1 NRP2 GABRA5	2.58e-03	104	77	3	C0494475

Protein segments in the cluster

Peptide	Gene	Start	Entry
FWDVGGQEKLRPLWK	ARL4C	66	P56559
NDWWIGRLVKEGGDI	CACNB3	101	P54284
GKRGGKKDDSHWWSR	AFG3L2	116	Q9Y4W6
DKDGWLHTGDIGKWL	ACSL1	531	P33121
EGKQKWEAWKALGDS	ACBD6	91	Q9BR61
SWNVDGLRAWIKKKG	APEX1	66	P27695
TTEGKLWSWGRNEKG	RCC2	166	Q9P258
RSQGDKKTWRWGPEG	PADI1	131	Q9ULC6
KGIFLGDDEWRETAW	PUM2	36	Q8TB72
DWIKRDDTWGGAIEI	YOD1	211	Q5VVQ6
GWLEGVRLADGEKGW	ARHGEF19	751	Q8IW93
GKGWEWGKDDSDNVR	OTUD7B	396	Q6GQQ9
WHWELSGKGKEEETL	GJC3	101	Q8NFK1
GLGDRLGWRDKATWL	DNAJC14	351	Q6Y2X3
TTISWWKDGKELLGA	MERTK	126	Q12866
LGDEKGLKFPSVWDW	MTMR10	526	Q9NXD2
GAARKPSGAGWEKEW	FUT4	6	P22083
EVAEELHWKGWELGK	CFAP65	146	Q6ZU64
CGRWLDKKRGDGLTW	LOXHD1	2046	Q8IVV2
WELGKVKGLKLEELW	NXF5	201	Q9H1B4
KLLWVIREDQGGEWK	NRP2	741	O60462
WDIGWLHELGKRLEV	KCNH4	396	Q9UQ05
KRGWAWDGKKALEAA	GABRA5	346	P31644
RKWPVAWGKLDDGSI	HELZ	936	P42694
WWGRLEGAKASAKGE	LINC00482	211	Q8N8I6
GTLDQWGIGVGRKKW	IL36B	121	Q9NZH7
KTWLLSEKKGVWGVF	TMEM167B	31	Q9NRX6
WVKEHVGDRGLWGLV	HSD17B6	96	O14756
LAKWAEGKTGFPWID	CRY2	346	Q49AN0
GGWREKEKAREESWG	EIF3A	1176	Q14152
EKNLLIFGWGRWKDI	CHD6	1101	Q8TD26
RWEEGKKWQAKIEGI	CEP290	1911	O15078
DEDGEWWIAKQRGKR	CRISPLD1	41	Q9H336
LFEVGAGWIGKLRWE	HSD17B4	236	P51659
KGEKLQVLKGTGDWW	BLK	81	P51451
GDVILVTKKDGDWWT	ITSN1	1026	Q15811
VTKKDGDWWTGTVGD	ITSN1	1031	Q15811
ILIRKKNPGGWWEGE	ITSN1	1101	Q15811
WLGDGLLLSVGDKWR	CYP4F8	131	P98187
IVDDWANDGWGLKKA	CANX	446	P27824
KVGTLWREAGLSWKE	EIF4G1	1391	Q04637
VGWKKERVVAEFWDG	ESCO2	421	Q56NI9
WDWKKGEKLSIARGS	EML5	801	Q05BV3
LWRGGRELSDWIKIG	SACS	51	Q9NZJ4
KVGALWREADLSWKD	EIF4G3	1371	O43432
GEILLVIEKKPDGWW	NPHP1	176	O15259
IIHEKKEGGWWFGSL	NOSTRIN	466	Q8IVI9
GEKLRVISDEGGWWK	SLA	46	Q13239
KVKRERGWSGNSWGG	MRPS5	186	P82675
GWKEGTWEEKVDERP	POFUT2	146	Q9Y2G5
WVKECVRDKGLWGLV	RDH16	96	O75452
EKEGRGWTQWIEGDE	RBP1	101	P09455
EIPGKDGVWRVLWKD	PNMA8B	81	Q9ULN7
DVGARDKWGKTALHW	NOTCH4	1726	Q99466
EKENRGWKQWIEGDK	RBP2	101	P50120
IGKGRFGEVWRGKWR	TGFBR1	211	P36897
FGEVWRGKWRGEEVA	TGFBR1	216	P36897
LLGWKQGDEEEKWAE	SMAD9	21	O15198
KRLLGWKQGDEEEKW	SMAD5	16	Q99717
RLLGWKQGDEEEKWA	SMAD1	16	Q15797
GTTLRLDVWDGWKEF	ANKUB1	151	A6NFN9
WKKWLDDEGQDGLRE	CHST3	321	Q7LGC8
WWEKGLPAKEDTGKT	NCAPG2	151	Q86XI2
KDLGRGDCEGWLWKK	CNKSR2	566	Q8WXI2
VERWWKVPLAGEGRK	MRPL9	56	Q9BYD2
WKSKSGRGLAGREPW	VWC2	76	Q2TAL6
WVLDRKGAKKSQGLW	ZNF250	81	P15622
IRDWRGPQLEGEKDW	ZSWIM9	556	Q86XI8
EWIKNWEKSGRGEFL	THOC2	11	Q8NI27
LWKNWESIGEGEGQK	ZNF519	81	Q8TB69
EKKNRGWTHWIEGDK	RBP7	101	Q96R05
LVDDSNEDWWKGKIG	STAC2	321	Q6ZMT1
NEDWWKGKIGDRVGF	STAC2	326	Q6ZMT1
FWRPWVDAGGKKEEE	RIPPLY2	36	Q5TAB7
SVRWKKDGQWLQGDD	ROBO3	481	Q96MS0
WEIEVGDKSEWAIGI	TRIM75	351	A6NK02
IEEGKGKLWWNLRKT	SCN2A	1186	Q99250
KETEWKWRGLVEAID	TEX264	196	Q9Y6I9
WKGVLEELLWFIKGS	TYMS	81	P04818
WVTGWGKTPEREKLA	PRSS42P	201	Q7Z5A4
IEEGLGKSWWILRKT	SCN8A	1176	Q9UQD0
WIKFEEKVEQGGERW	SLC4A4	131	Q9Y6R1
GTLRGWLKDEPKLRW	TIGD5	86	Q53EQ6
NEEWWRGKIGEKVGF	STAC3	281	Q96MF2
GITDVWLRTDKDWKA	MYO7B	726	Q6PIF6
KERIQWVGDPRWKDG	MPZ	96	P25189