Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZBTB47 HOXB2 DMRTB1 MLXIPL ZNF526 ATF5 CEBPB ZNF628 ONECUT3 HOXD8 ZIC5 MNT SKOR2 ZBTB21

5.90e-0714124214GO:0000981
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

HOXB2 MLXIPL ATF5 CEBPB ZNF628 ONECUT3 HOXD8

1.51e-04560427GO:0001228
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

DMRTB1 MLXIPL ZNF526 ATF5 CEBPB ZNF628 ONECUT3 HOXD8 ZIC5 MNT SKOR2

1.58e-0414594211GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

HOXB2 MLXIPL ATF5 CEBPB ZNF628 ONECUT3 HOXD8

1.61e-04566427GO:0001216
GeneOntologyMolecularFunctionSH3 domain binding

DOCK1 FMN1 WASF2 WIPF3

2.28e-04143424GO:0017124
GeneOntologyMolecularFunctionactin binding

LMOD1 FMN1 PXK WASF2 ESPNL WIPF3

4.66e-04479426GO:0003779
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

DMRTB1 MLXIPL ZNF526 CEBPB ZNF628 ONECUT3 ZIC5 MNT SKOR2

9.44e-041244429GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

DMRTB1 MLXIPL ZNF526 CEBPB ZNF628 ONECUT3 ZIC5 MNT SKOR2

1.10e-031271429GO:0000987
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

KMT2B KMT2E

3.86e-0344422GO:0140938
GeneOntologyMolecularFunctionchromatin binding

TRIM66 ATF5 CEBPB PELP1 MNT SKOR2

4.24e-03739426GO:0003682
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

MLXIPL CEBPB MNT ZBTB21

4.49e-03320424GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

MLXIPL CEBPB MNT ZBTB21

4.79e-03326424GO:0001217
GeneOntologyBiologicalProcessactin nucleation

LMOD1 FMN1 WASF2 WIPF3

9.19e-0665424GO:0045010
GeneOntologyCellularComponentchromatin

TRIM66 HOXB2 DMRTB1 MLXIPL ATF5 CEBPB ONECUT3 KMT2E HOXD8 PELP1 MNT

1.19e-0414804211GO:0000785
DomainWH2

LMOD1 PXK WASF2 WIPF3

3.22e-0816404PF02205
DomainWH2_dom

LMOD1 PXK WASF2 WIPF3

1.05e-0721404IPR003124
DomainWH2

LMOD1 PXK WASF2 WIPF3

1.86e-0724404PS51082
DomainWH2

LMOD1 WASF2 WIPF3

3.26e-0614403SM00246
DomainFH2

GRID2IP FMN1

4.61e-0415402PS51444
DomainFH2_Formin

GRID2IP FMN1

4.61e-0415402IPR015425
DomainFH2

GRID2IP FMN1

4.61e-0415402PF02181
DomainFH2

GRID2IP FMN1

4.61e-0415402SM00498
DomainPHD

TRIM66 KMT2B KMT2E

5.52e-0475403PF00628
DomainZnf_PHD-finger

TRIM66 KMT2B KMT2E

6.43e-0479403IPR019787
DomainPHD

TRIM66 KMT2B KMT2E

9.10e-0489403SM00249
DomainHomeobox_Antennapedia_CS

HOXB2 HOXD8

9.15e-0421402IPR001827
DomainZnf_PHD

TRIM66 KMT2B KMT2E

9.70e-0491403IPR001965
DomainZF_PHD_2

TRIM66 KMT2B KMT2E

1.10e-0395403PS50016
DomainZF_PHD_1

TRIM66 KMT2B KMT2E

1.13e-0396403PS01359
DomainANTENNAPEDIA

HOXB2 HOXD8

1.20e-0324402PS00032
Domain-

TRIM66 KMT2B KMT2E RBBP6 RNF215

2.58e-034494053.30.40.10
DomainZnf_RING/FYVE/PHD

TRIM66 KMT2B KMT2E RBBP6 RNF215

2.84e-03459405IPR013083
DomainSET

KMT2B KMT2E

3.48e-0341402PF00856
DomainZnf_FYVE_PHD

TRIM66 KMT2B KMT2E

3.81e-03147403IPR011011
DomainSET

KMT2B KMT2E

4.36e-0346402SM00317
DomainSET_dom

KMT2B KMT2E

5.13e-0350402IPR001214
DomainSET

KMT2B KMT2E

5.13e-0350402PS50280
DomainBRLZ

ATF5 CEBPB

5.54e-0352402SM00338
DomainBZIP

ATF5 CEBPB

5.75e-0353402PS50217
DomainBZIP_BASIC

ATF5 CEBPB

5.75e-0353402PS00036
DomainbZIP

ATF5 CEBPB

5.97e-0354402IPR004827
DomainZnf_C2H2

ZBTB47 ZNF526 SORBS2 ZNF628 ZIC5 ZBTB21

6.90e-03805406IPR007087
DomainZinc_finger_PHD-type_CS

TRIM66 KMT2E

8.54e-0365402IPR019786
DomainSH3_9

DOCK1 SORBS2

1.21e-0278402PF14604
DomainHomeobox

HOXB2 ONECUT3 HOXD8

1.36e-02234403PF00046
DomainHOMEOBOX_1

HOXB2 ONECUT3 HOXD8

1.40e-02236403PS00027
DomainHOX

HOXB2 ONECUT3 HOXD8

1.41e-02237403SM00389
Domain-

ZBTB47 ZNF526 ZNF628 ZIC5 ZBTB21

1.44e-026794053.30.160.60
DomainHomeobox_dom

HOXB2 ONECUT3 HOXD8

1.44e-02239403IPR001356
DomainHOMEOBOX_2

HOXB2 ONECUT3 HOXD8

1.44e-02239403PS50071
Pubmed

A census of human transcription factors: function, expression and evolution.

HOXB2 DMRTB1 MLXIPL ATF5 CEBPB ONECUT3 HOXD8 MNT SKOR2

1.11e-0690842919274049
Pubmed

Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance.

DOCK1 WASF2

1.42e-06242211773052
Pubmed

Dominant-Negative ATF5 Compromises Cancer Cell Survival by Targeting CEBPB and CEBPD.

ATF5 CEBPB

4.27e-06342231676720
Pubmed

p300-dependent acetylation of activating transcription factor 5 enhances C/EBPβ transactivation of C/EBPα during 3T3-L1 differentiation.

ATF5 CEBPB

8.53e-06442224216764
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

SMN1 CEBPB PRR11 KMT2B RBBP6 FAM120C CCNK MTFR1 WASF2 C6orf132

8.83e-061497421031527615
Pubmed

WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network.

MLXIPL MNT

1.42e-05542211230181
Pubmed

cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein.

ATF5 CEBPB

1.42e-0554221371974
Pubmed

Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.

KMT2B KMT2E

3.97e-05842223130995
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

HOXB2 CEBPB ONECUT3 HOXD8 ZIC5 SKOR2

4.63e-0554442628473536
Pubmed

The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.

HOXB2 HOXD8

5.10e-0594227913891
Pubmed

Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.

KMT2B FMN1

1.28e-04144228605874
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

FIP1L1 MLXIPL CEBPB KMT2B PELP1 ZIC5 RBBP6 MNT

1.37e-04129442830804502
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

DOCK1 ATF5 KMT2E RBBP6 C6orf132

1.65e-0443042535044719
Pubmed

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.

CEBPB KMT2B

1.69e-041642224368734
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

FIP1L1 KMT2B RBBP6 CCNK

2.39e-0425142431076518
Pubmed

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.

DOCK1 RBBP6 WIPF3

2.66e-0410342321706016
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KMT2B KMT2E

2.95e-042142227626377
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

FIP1L1 SORBS2 KMT2B RBBP6 CCNK ZBTB21

3.16e-0477442615302935
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

KMT2B KMT2E

3.24e-042242226886794
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

KMT2B RBBP6 CCNK WASF2 WIPF3

3.49e-0450642530890647
Pubmed

Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells.

MLXIPL CEBPB

3.54e-042342227974211
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

FIP1L1 SMN1 KMT2B PELP1 RBBP6 CCNK

5.09e-0484742635850772
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

FIP1L1 CEBPB PELP1 MNT WASF2 ZBTB21

5.41e-0485742625609649
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

FIP1L1 MLXIPL SORBS2 R3HDM1 C6orf132 ZBTB21

5.55e-0486142636931259
Pubmed

Gene expression and characterization of clonally derived murine embryonic brown and brite adipocytes.

MLXIPL CEBPB

5.66e-042942238972757
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

FIP1L1 KMT2B CCNK

5.75e-0413442325452129
Pubmed

Molecular design of hypothalamus development.

ONECUT3 ZIC5

6.47e-043142232499648
Pubmed

Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).

KMT2E RBBP6

6.47e-043142226678539
Pubmed

HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages.

SMN1 SORBS2

6.90e-043242227114546
Pubmed

HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.

CEBPB MNT

6.90e-043242211748221
Pubmed

Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays.

ATF5 CEBPB

7.34e-043342220102225
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

FIP1L1 SMN1 RBBP6 FAM120C

7.58e-0434142432971831
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

R3HDM1 PELP1 CCNK

8.29e-0415242338360978
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

FIP1L1 CCNK WASF2

8.61e-0415442316055720
Pubmed

Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).

R3HDM1 MTFR1

9.23e-04374227584028
Pubmed

The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation.

MLXIPL CEBPB

9.23e-043742235863637
Pubmed

Identification of 10 murine homeobox genes.

HOXB2 HOXD8

9.74e-04384221683707
Pubmed

Atlas of Hox gene expression in the developing kidney.

HOXB2 HOXD8

9.74e-043842215042701
Pubmed

Complete mutation analysis panel of the 39 human HOX genes.

HOXB2 HOXD8

9.74e-043842211857506
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SORBS2 PRRT1 PELP1 FAM120C WASF2 ZBTB21

9.94e-0496342628671696
Pubmed

Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.

SORBS2 PXK

1.03e-033942222802532
Pubmed

Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster.

HOXB2 HOXD8

1.03e-033942233257809
Pubmed

Quantification of Hox and surfactant protein-B transcription during murine lung development.

HOXB2 HOXD8

1.08e-034042219204410
Pubmed

Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates.

HOXB2 HOXD8

1.13e-034142232479258
Pubmed

Hepatitis C virus infection protein network.

SORBS2 HOXD8

1.19e-034242218985028
InteractionNCK2 interactions

DOCK1 ZNF526 SORBS2 ONECUT3 HOXD8 MNT WASF2 WIPF3

5.91e-08262428int:NCK2
InteractionP4HA1 interactions

FIP1L1 TRIM66 SMN1 ZNF526 CEBPB ZNF628

3.33e-05298426int:P4HA1
InteractionPRPF40A interactions

FIP1L1 CEBPB KMT2B PELP1 MAPKAPK2 FMN1 WASF2

3.42e-05446427int:PRPF40A
InteractionALG13 interactions

TRIM66 DMRTB1 R3HDM1 FAM120C CCNK

3.79e-05183425int:ALG13
InteractionCPSF4 interactions

FIP1L1 CEBPB RBBP6 MAPKAPK2

4.34e-0594424int:CPSF4
InteractionPFN1 interactions

DOCK1 GRID2IP CEBPB MTFR1 WASF2 C6orf132 WIPF3

7.89e-05509427int:PFN1
Cytoband1q32

LMOD1 MAPKAPK2

9.35e-04494221q32
GeneFamilyPHD finger proteins

TRIM66 KMT2B KMT2E

2.85e-049026388
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2B KMT2E

1.08e-0334262487
GeneFamilyBasic leucine zipper proteins

ATF5 CEBPB

2.24e-0349262506
GeneFamilyHOXL subclass homeoboxes

HOXB2 HOXD8

2.52e-0352262518
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZBTB47 ZNF526 ZNF628 ZIC5 ZBTB21

3.20e-0371826528
GeneFamilyBasic helix-loop-helix proteins

MLXIPL MNT

1.08e-02110262420
GeneFamilyBasic leucine zipper proteins|BTB domain containing

ZBTB47 ZBTB21

1.58e-02134262861
CoexpressionGSE17721_PAM3CSK4_VS_CPG_0.5H_BMDC_UP

MLXIPL CEBPB CCNK WASF2 ZBTB21

1.66e-05200425M3850
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM66 MLXIPL ATF5 PRRT1

1.71e-05164424b895674ed2df87db8fbfb30b7e31620945588491
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMOD1 ATF5 CEBPB MTFR1

2.74e-0518542438486b69c48dc5e1c4e1488208fa8954a973eccb
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMOD1 ATF5 CEBPB MTFR1

2.74e-051854243c28b5ceba3cfdb6f7e32d5b42e03b6a81a7a658
ToppCelldroplet-Tongue-TONGUE|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATF5 GRID2IP CEBPB WASF2

3.43e-0519642444a30b1a5f3d8c845e5f3bd17d8102a7449f555b
ToppCelldroplet-Tongue-TONGUE-1m|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATF5 GRID2IP CEBPB WASF2

3.43e-051964249935bdb10789e8cfc922dca526ca3bf8317fe270
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATF5 GRID2IP CEBPB WASF2

3.43e-05196424a85f5f1e6acc798e9e02b1a21e0ffe87a323c333
Diseaselevel of Sphingomyelin (d42:2) in blood serum

MLXIPL PELP1

7.11e-0429402OBA_2045183
Diseasefacial pigmentation measurement

SORBS2 FMN1

2.73e-0357402EFO_0006942
DiseaseAPOE carrier status, dementia

SORBS2 ZIC5

3.22e-0362402EFO_0007659, MONDO_0001627
Diseaseheart rate

GRID2IP RBBP6 C6orf132

3.51e-03225403EFO_0004326
DiseaseLiver carcinoma

MLXIPL CEBPB KMT2B ZIC5

4.83e-03507404C2239176
Diseasealcohol drinking

KMT2E MNT

5.43e-0381402EFO_0004329

Protein segments in the cluster

PeptideGeneStartEntry
HPAEPPAPPGPPPPP

ELFN1

711

P0C7U0
HQPPPLPHRPPPPPP

CCNK

411

O75909
HVYPPNPPPPPVPPP

CCNK

476

O75909
SPPPLPPPPLPPAPS

ATF5

126

Q9Y2D1
TAAPPPHPPPPPPPP

R3HDM1

586

Q15032
PPPPPPPLPPPSSAG

FMN1

906

Q68DA7
PPLPPPSSAGPPPPP

FMN1

911

Q68DA7
PSSAGPPPPPPPPPL

FMN1

916

Q68DA7
PLLMTPPPPPFPPPP

ESPNL

331

Q6ZVH7
PALPHPPAQPPPPPP

MAPKAPK2

26

P49137
QAAPPPPPHPPPPPP

HOXD8

106

P13378
PAAPPPPPPPLAPPL

LMOD1

531

P29536
PTHLPPPPFLPPPPT

FIP1L1

366

Q6UN15
VPPPPPPPPAPGPHL

KMT2E

1626

Q8IZD2
PLSPPAPPPAPPPPL

MNT

66

Q99583
LPPPPLTPPAPSPPP

KMT2B

401

Q9UMN6
LTPPAPSPPPPLPPP

KMT2B

406

Q9UMN6
STSPPPPLCPPPPPP

KMT2B

421

Q9UMN6
PPLPPPPPSGATPPP

PELP1

796

Q8IZL8
PPPPHTLPLPPGVPP

RBBP6

566

Q7Z6E9
PALPPPPPPPLPAAP

HOXB2

76

P14652
GTIPPHPPPPPPPLP

MTFR1

181

Q15390
HPPPPPPPLPPPALG

MTFR1

186

Q15390
LPPPAPPLPPPAPPL

C6orf132

396

Q5T0Z8
PPLPPPAPPLPPAAP

C6orf132

401

Q5T0Z8
PPPLSPPPPPPLPFH

GRID2IP

751

A4D2P6
LSHPVPPPPPPPLPP

GRID2IP

791

A4D2P6
LPPPLPSKTPPPPPP

DOCK1

1836

Q14185
ALHFLPPPPPPPPPS

DMRTB1

291

Q96MA1
CFAPLHPPPPPPPPP

CEBPB

156

P17676
LHPPLPPPPPPQLPG

FAM120C

101

Q9NX05
RPVPSPHPPPLPLPP

MAMLD1

341

Q13495
PHPPPLPLPPPPPPF

MAMLD1

346

Q13495
IKPPPPPLPPHPATP

GAPDHS

51

O14556
PLPPPPPAAAAPPPP

PRRT1

121

Q99946
HGAPQPPPPPPPPPL

ONECUT3

211

O60422
SPPPPPPPPPSPLLL

RNF215

11

Q9Y6U7
GPPPPPPPPPPHLLS

SMN1

216

Q16637
PPPPPLPPPLPSSSP

WIPF3

181

A6NGB9
LPPPPVPPPLLHYPP

MLXIPL

386

Q9NP71
SPVPPPHVPPPVPPL

SORBS2

166

O94875
SPSPPPLPPPPPLPK

ZBTB21

981

Q9ULJ3
ISALPPPPPPPPPPA

PXK

511

Q7Z7A4
LPQTLPPPPHLPPPP

ZBTB47

716

Q9UFB7
PPPPHLPPPPPLFPT

ZBTB47

721

Q9UFB7
PPPPPPPPPPPLAQH

SKOR2

696

Q2VWA4
PPHPDFAAPPPPPPP

WASF2

356

Q9Y6W5
PLPPPTPLPPPSPPS

ZNF526

176

Q8TF50
QLPPPPPPLPHPPPP

TRIM66

456

O15016
ASHFPPPPPPPPLPP

PRR11

181

Q96HE9
QPHSPPAPPAPPPPP

ZNF628

261

Q5EBL2
PPPAPPPPPAPAQHP

ZIC5

356

Q96T25