Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	metallopeptidase activity	MMP24 CLCA4 CPN1 MMP16 MMP19 ADAM22	1.16e-05	200	51	6	GO:0008237
GeneOntologyMolecularFunction	metalloendopeptidase activity	MMP24 CLCA4 MMP16 MMP19 ADAM22	1.36e-05	120	51	5	GO:0004222
GeneOntologyBiologicalProcess	protein depolymerization	MICAL1 SH3GL1 SH3GL2 KIF18B ADD1	2.55e-05	144	50	5	GO:0051261
Domain	EIF3C_N_dom	EIF3C EIF3CL	6.47e-06	2	48	2	IPR008905
Domain	eIF-3c_N	EIF3C EIF3CL	6.47e-06	2	48	2	PF05470
Domain	EIF3C	EIF3C EIF3CL	6.47e-06	2	48	2	IPR027516
Domain	Pept_M10A_stromelysin-type	MMP24 MMP16 MMP19	1.27e-05	18	48	3	IPR016293
Domain	PG_binding_1	MMP24 MMP16 MMP19	1.76e-05	20	48	3	PF01471
Domain	Peptidoglycan-bd-like	MMP24 MMP16 MMP19	1.76e-05	20	48	3	IPR002477
Domain	Hemopexin-like_dom	MMP24 MMP16 MMP19	2.72e-05	23	48	3	IPR000585
Domain	Hemopexin-like_repeat	MMP24 MMP16 MMP19	2.72e-05	23	48	3	IPR018487
Domain	M10A_MMP	MMP24 MMP16 MMP19	2.72e-05	23	48	3	IPR033739
Domain	Hemopexin	MMP24 MMP16 MMP19	2.72e-05	23	48	3	PF00045
Domain	HEMOPEXIN	MMP24 MMP16 MMP19	2.72e-05	23	48	3	PS00024
Domain	-	MMP24 MMP16 MMP19	2.72e-05	23	48	3	2.110.10.10
Domain	HEMOPEXIN_2	MMP24 MMP16 MMP19	2.72e-05	23	48	3	PS51642
Domain	HX	MMP24 MMP16 MMP19	2.72e-05	23	48	3	SM00120
Domain	Pept_M10A	MMP24 MMP16 MMP19	2.72e-05	23	48	3	IPR021190
Domain	Peptidase_M10	MMP24 MMP16 MMP19	3.10e-05	24	48	3	PF00413
Domain	DUF3377	MMP24 MMP16	3.87e-05	4	48	2	PF11857
Domain	Pept_M10A_metallopeptidase_C	MMP24 MMP16	3.87e-05	4	48	2	IPR021805
Domain	MetalloPept_cat_dom	MMP24 MMP16 MMP19 ADAM22	5.52e-05	81	48	4	IPR024079
Domain	-	MMP24 MMP16 MMP19 ADAM22	5.52e-05	81	48	4	3.40.390.10
Domain	ZnMc	MMP24 MMP16 MMP19	5.55e-05	29	48	3	SM00235
Domain	Peptidase_Metallo	MMP24 MMP16 MMP19	5.55e-05	29	48	3	IPR006026
Domain	ZINC_PROTEASE	MMP24 MMP16 MMP19 ADAM22	1.16e-04	98	48	4	PS00142
Domain	CYSTEINE_SWITCH	MMP24 MMP16 MMP19	1.59e-04	41	48	3	PS00546
Domain	Pept_M10_metallopeptidase	MMP24 MMP16 MMP19	1.83e-04	43	48	3	IPR001818
Domain	-	KAT6A IRF1 E2F4 EIF3C EIF3CL	2.36e-04	218	48	5	1.10.10.10
Domain	WHTH_DNA-bd_dom	KAT6A IRF1 E2F4 EIF3C EIF3CL	3.81e-04	242	48	5	IPR011991
Domain	RECEPTOR_TYR_KIN_II	IGF1R PTK7	4.20e-04	12	48	2	PS00239
Domain	Spectrin_alpha_SH3	SH3GL1 SH3GL2	6.65e-04	15	48	2	IPR013315
Domain	BAR	SH3GL1 SH3GL2	6.65e-04	15	48	2	SM00721
Domain	BAR	SH3GL1 SH3GL2	6.65e-04	15	48	2	PF03114
Domain	BAR_dom	SH3GL1 SH3GL2	7.58e-04	16	48	2	IPR004148
Domain	PINT	EIF3C EIF3CL	7.58e-04	16	48	2	SM00088
Domain	Hemopexin_CS	MMP24 MMP16	8.58e-04	17	48	2	IPR018486
Domain	PCI_dom	EIF3C EIF3CL	8.58e-04	17	48	2	IPR000717
Domain	PCI	EIF3C EIF3CL	8.58e-04	17	48	2	PF01399
Domain	BAR	SH3GL1 SH3GL2	1.08e-03	19	48	2	PS51021
Domain	-	SH3GL1 SH3GL2	2.69e-03	30	48	2	1.20.1270.60
Domain	AH/BAR-dom	SH3GL1 SH3GL2	2.69e-03	30	48	2	IPR027267
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP24 MMP16 MMP19	6.81e-05	29	39	3	MM15981
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP24 MMP16 MMP19	7.55e-05	30	39	3	M39652
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	MMP24 AHCYL1 IGF1R KAT6A EIF3C CPN1 MMP16 KCNH3 EIF3CL	1.24e-06	730	52	9	34857952
Pubmed	EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.	EIF3C EIF3CL	2.19e-06	2	52	2	36157221
Pubmed	Matrix metalloproteinases.	MMP24 MMP16 MMP19	4.76e-06	22	52	3	10419448
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP24 MMP16 MMP19	4.76e-06	22	52	3	23421805
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TXNL1 EPRS1 AHCYL1 SH3GL1 SH3GL2 EIF3C ADAM22 GATAD2B PTK7 EIF3CL	6.18e-06	1139	52	10	36417873
Pubmed	Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.	MMP24 MMP16 MMP19	6.24e-06	24	52	3	15734845
Pubmed	Association Study of GWAS-Derived Loci with Height in Brazilian Children: Importance of MAP3K3, MMP24 and IGF1R Polymorphisms for Height Variation.	MMP24 IGF1R	6.57e-06	3	52	2	26304632
Pubmed	Single point mutation in Bin/Amphiphysin/Rvs (BAR) sequence of endophilin impairs dimerization, membrane shaping, and Src homology 3 domain-mediated partnership.	SH3GL1 SH3GL2	6.57e-06	3	52	2	22167186
Pubmed	Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.	SH3GL1 SH3GL2	1.31e-05	4	52	2	32152276
Pubmed	EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.	SH3GL1 SH3GL2	1.31e-05	4	52	2	9122235
Pubmed	Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC).	MMP24 MMP16	1.31e-05	4	52	2	35062057
Pubmed	Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins.	SH3GL1 SH3GL2	1.31e-05	4	52	2	10816441
Pubmed	Synaptojanin and Endophilin Mediate Neck Formation during Ultrafast Endocytosis.	SH3GL1 SH3GL2	1.31e-05	4	52	2	29953872
Pubmed	LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.	SH3GL1 SH3GL2	1.31e-05	4	52	2	22998870
Pubmed	Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.	EIF3C EIF3CL	1.31e-05	4	52	2	10504338
Pubmed	Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System.	SH3GL1 SH3GL2	2.19e-05	5	52	2	27720640
Pubmed	mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.	MMP24 MMP16	2.19e-05	5	52	2	12661033
Pubmed	Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.	SH3GL1 SH3GL2	2.19e-05	5	52	2	12034747
Pubmed	Calmodulin Promotes N-BAR Domain-Mediated Membrane Constriction and Endocytosis.	SH3GL1 SH3GL2	2.19e-05	5	52	2	27093085
Pubmed	MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.	MMP24 MMP16	2.19e-05	5	52	2	29196321
Pubmed	Upregulation of Parkin in endophilin mutant mice.	SH3GL1 SH3GL2	2.19e-05	5	52	2	25471590
Pubmed	Binding properties of SH3 peptide ligands identified from phage-displayed random peptide libraries.	SH3GL1 SH3GL2	3.28e-05	6	52	2	9238627
Pubmed	Role of dynamin, synaptojanin, and endophilin in podocyte foot processes.	SH3GL1 SH3GL2	3.28e-05	6	52	2	23187129
Pubmed	The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis.	SH3GL1 SH3GL2	3.28e-05	6	52	2	10764144
Pubmed	A novel SH3-containing human gene family preferentially expressed in the central nervous system.	SH3GL1 SH3GL2	3.28e-05	6	52	2	9169142
Pubmed	Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.	SH3GL1 SH3GL2	3.28e-05	6	52	2	28235806
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	FOCAD EPRS1 FLNC AHCYL1 PAIP2 E2F4	3.38e-05	411	52	6	36652389
Pubmed	Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.	CHD8 GATAD2B	4.58e-05	7	52	2	26816381
Pubmed	Endophilin A1 regulates dendritic spine morphogenesis and stability through interaction with p140Cap.	SH3GL1 SH3GL2	4.58e-05	7	52	2	25771685
Pubmed	The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.	SH3GL1 SH3GL2	4.58e-05	7	52	2	10542231
Pubmed	Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.	MMP24 MMP16	4.58e-05	7	52	2	12879005
Pubmed	Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin.	SH3GL1 SH3GL2	4.58e-05	7	52	2	9341169
Pubmed	Membrane-type matrix metalloproteinases: Their functions and regulations.	MMP24 MMP16	4.58e-05	7	52	2	25794647
Pubmed	Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.	SH3GL1 SH3GL2	6.10e-05	8	52	2	11894095
Pubmed	SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination.	SH3GL1 SH3GL2	6.10e-05	8	52	2	20064468
Pubmed	Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.	SH3GL1 SH3GL2	6.10e-05	8	52	2	16115810
Pubmed	Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission.	SH3GL1 SH3GL2	6.10e-05	8	52	2	22099461
Pubmed	The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.	EIF3C EIF3CL	7.84e-05	9	52	2	24003236
Pubmed	The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.	EIF3C EIF3CL	7.84e-05	9	52	2	21292980
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	TXNL1 FLNC AHCYL1 ECD SH3GL1 EIF3C ATP2A1 PTK7	9.28e-05	974	52	8	28675297
Pubmed	mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.	EIF3C EIF3CL	9.79e-05	10	52	2	16286006
Pubmed	Conservation and diversity of eukaryotic translation initiation factor eIF3.	EIF3C EIF3CL	9.79e-05	10	52	2	8995409
Pubmed	The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.	SH3GL1 SH3GL2	1.20e-04	11	52	2	11894096
Pubmed	Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes.	MMP16 MMP19	1.20e-04	11	52	2	10949161
Pubmed	Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1.	SH3GL1 SH3GL2	1.20e-04	11	52	2	12456676
Pubmed	A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.	IGF1R PTK7	1.20e-04	11	52	2	8247543
Pubmed	Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3.	EIF3C EIF3CL	1.43e-04	12	52	2	14519125
Pubmed	Reconstitution reveals the functional core of mammalian eIF3.	EIF3C EIF3CL	1.43e-04	12	52	2	17581632
Pubmed	Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.	SH3GL1 SH3GL2	1.69e-04	13	52	2	23146885
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	RASGRF1 EIF3C ADAM22 ADD1 EIF3CL	1.70e-04	347	52	5	17114649
Pubmed	Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.	EIF3C EIF3CL	1.97e-04	14	52	2	18599441
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCNX2 FOCAD FLNC IGF1R KAT6A CHD8 TBC1D17 KCNH3	2.20e-04	1105	52	8	35748872
Pubmed	Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.	EIF3C EIF3CL	2.27e-04	15	52	2	17322308
Pubmed	Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins.	SH3GL1 SH3GL2	2.27e-04	15	52	2	9630982
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	EPRS1 MICAL1 FLNC AHCYL1 SH3GL1 EIF3C ADAM22 ADD1 EIF3CL	2.45e-04	1431	52	9	37142655
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	FOCAD EPRS1 MICAL1 ZNF671 SH3GL1 SH3GL2 EIF3C ADD1	2.47e-04	1124	52	8	21900206
Pubmed	Matrix metalloproteinases in tumor invasion.	MMP24 MMP16	2.60e-04	16	52	2	10949577
Pubmed	Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c.	EIF3C EIF3CL	2.94e-04	17	52	2	34752747
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	EPRS1 IGF1R SH3GL1 ADAM22 GATAD2B ADD1	3.21e-04	621	52	6	22794259
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	FLNC SH3GL2 EIF3C EIF3CL	4.00e-04	231	52	4	36597993
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	EPRS1 AHCYL1 BUB1 CHD8 TBC1D17 PTK7	4.08e-04	650	52	6	38777146
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	EPRS1 FLNC MRPS2 EIF3C	4.26e-04	235	52	4	30258100
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	FLNC AHCYL1 CHD8 EIF3C GATAD2B	5.26e-04	444	52	5	34795231
Pubmed	Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.	NRIP1 IGF1R E2F4 ADD1	5.38e-04	250	52	4	18660489
Pubmed	Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.	EPRS1 EIF3C ATP2A1 EIF3CL	5.88e-04	256	52	4	35777956
Pubmed	Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.	EPRS1 FLNC EIF3C EIF3CL	6.14e-04	259	52	4	31162944
Pubmed	A large set of estrogen receptor β-interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei.	NRIP1 MRPS2	6.43e-04	25	52	2	21182203
Pubmed	Genetic loci influencing natural variations in femoral bone morphometry in mice.	EIF3C EIF3CL	7.51e-04	27	52	2	11518254
Pubmed	Genetic mapping of eight SH3 domain genes on seven mouse chromosomes.	SH3GL1 SH3GL2	8.08e-04	28	52	2	10087302
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	EPRS1 CHD8 EIF3C GATAD2B EIF3CL	9.21e-04	503	52	5	16964243
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	EPRS1 ADAM22 ADD1	9.43e-04	128	52	3	30995482
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	EPRS1 MRPS2 CHD8 EIF3C GATAD2B	1.20e-03	534	52	5	35032548
Pubmed	α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.	TXNL1 ECD	1.26e-03	35	52	2	37381005
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	EPRS1 FLNC AHCYL1 MYO1A TESMIN ECD ATP2A1 PTK7	1.27e-03	1442	52	8	35575683
Pubmed	Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.	MMP24 MMP16	1.34e-03	36	52	2	20587546
Pubmed	Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.	EIF3C EIF3CL	1.34e-03	36	52	2	16097034
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	TXNL1 EPRS1 FLNC AHCYL1 SH3GL1 EIF3C TBC1D17 EIF3CL	1.34e-03	1455	52	8	22863883
Pubmed	Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase.	ECD IRF1 CHD8	1.43e-03	148	52	3	22898364
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP24 MMP16 MMP19	9.02e-06	24	31	3	891
GeneFamily	N-BAR domain containing	SH3GL1 SH3GL2	1.86e-04	12	31	2	1289
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	IGF1R PTK7	2.13e-03	40	31	2	321
Drug	Norgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; PC3; HT_HG-U133A	PCNX2 MICAL1 ZNF671 KAT6A ADCK2 E2F4	3.99e-06	197	49	6	3708_DN
Drug	DA-125	MMP24 MMP16 MMP19	2.35e-05	26	49	3	CID000114758
Drug	mercuric acetate	MMP24 MMP16 MMP19	3.65e-05	30	49	3	CID000015337
Drug	malolactomycin D	MMP24 MMP16 MMP19	4.45e-05	32	49	3	CID006449115
Drug	Fenbufen [36330-85-5]; Down 200; 15.8uM; PC3; HT_HG-U133A	NRIP1 AHCYL1 IGF1R KAT6A MMP16	5.57e-05	191	49	5	4279_DN
Drug	Iopanoic acid [96-83-3]; Down 200; 7uM; MCF7; HT_HG-U133A	KAT6A IRF1 ADCK2 MMP19 ADAM22	6.00e-05	194	49	5	5448_DN
Drug	Trihexyphenidyl-D,L Hydrochloride [58947-95-8]; Down 200; 11.8uM; PC3; HT_HG-U133A	MICAL1 BUB1 E2F4 ADAM22 TBC1D17	6.15e-05	195	49	5	4015_DN
Drug	haloperidol; Up 200; 10uM; MCF7; HT_HG-U133A_EA	EPRS1 DSPP MMP16 ADAM22 TCTN2	6.15e-05	195	49	5	983_UP
Drug	0317956-0000 [391210-11-0]; Up 200; 1uM; MCF7; HT_HG-U133A	PCNX2 BUB1 CPN1 MMP16 ATP2A1	6.15e-05	195	49	5	3969_UP
Drug	Mebhydroline 1,5-naphtalenedisulfonate [6153-33-9]; Up 200; 4.8uM; HL60; HT_HG-U133A	ZNF671 SH3GL1 ADCK2 MMP19 ADD1	6.30e-05	196	49	5	1333_UP
Drug	Myosmine [532-12-7]; Up 200; 27.4uM; PC3; HT_HG-U133A	IGF1R KAT6A E2F4 MMP16 ADAM22	6.45e-05	197	49	5	3737_UP
Drug	Flunixin meglumine [42461-84-7]; Up 200; 8.2uM; MCF7; HT_HG-U133A	PCNX2 MICAL1 DSPP ADCK2 TBC1D17	6.45e-05	197	49	5	3411_UP
Drug	Cefixime [79350-37-1]; Up 200; 8.8uM; MCF7; HT_HG-U133A	PCNX2 DSPP KAT6A E2F4 MMP19	6.45e-05	197	49	5	3247_UP
Drug	PF-01378883-00 [351320-41-7]; Down 200; 10uM; PC3; HT_HG-U133A	MMP24 IGF1R KAT6A MMP16 ADAM22	6.77e-05	199	49	5	6368_DN
Drug	Folinic acid calcium salt [6035-45-6]; Down 200; 7.8uM; MCF7; HT_HG-U133A	MICAL1 DSPP KAT6A ADAM22 TCTN2	6.77e-05	199	49	5	4725_DN
Drug	Furazolidone [67-45-8]; Down 200; 17.8uM; PC3; HT_HG-U133A	PCNX2 MMP24 BUB1 ADCK2 TBC1D17	6.77e-05	199	49	5	4098_DN
Disease	smoking status measurement	FOCAD AHCYL1 IGF1R SH3GL1 C1QTNF7 ADD1 STPG2 KCNH3	6.88e-04	1160	50	8	EFO_0006527
Disease	IgA glomerulonephritis (is_implicated_in)	IGF1R ADD1	1.19e-03	30	50	2	DOID:2986 (is_implicated_in)
Disease	conduct disorder	C1QTNF7 GATAD2B	1.27e-03	31	50	2	EFO_0004216
Disease	osteoporosis (is_implicated_in)	NRIP1 IGF1R	1.27e-03	31	50	2	DOID:11476 (is_implicated_in)
Disease	left ventricular mass index	FLNC IGF1R	1.52e-03	34	50	2	EFO_0009290
Disease	high grade glioma (is_implicated_in)	IGF1R SH3GL1	2.32e-03	42	50	2	DOID:3070 (is_implicated_in)
Disease	high grade glioma (implicated_via_orthology)	IGF1R SH3GL1	2.54e-03	44	50	2	DOID:3070 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EPPGNVKGKRPYQEG	PI16	166	Q6UXB8
YLGNGRKPPENLADQ	ADCK2	256	Q7Z695
YKPLQGPPKDQDDEG	CHD8	1696	Q9HCK8
EDGNKENYGLPQPKN	BUB1	531	O43683
ENYGLPQPKNKPTGA	BUB1	536	O43683
QRQLPQGDYVKKPGD	ADAM22	766	Q9P0K1
VNIEGPGQKSEPGNK	DSPP	421	Q9NZW4
QNQPFNLKYKPGKGG	ECD	56	O95905
LKNDKPVRPGQYDGL	ATP2A1	396	O14983
LNPNAKEFVPGVKYG	PAIP2	111	Q9BPZ3
VDGKGYLLNEPGVQP	IRF1	251	P10914
LNKGVFGEKPNLPEY	KCNH3	191	Q9ULD8
QDDLQGIQKIYGPPA	MMP24	316	Q9Y5R2
GDYIGLQGNPKLQKL	MYO1A	871	Q9UBC5
LEQEKNKGYLPGQGP	ASAH2	326	Q9NR71
NPKYGAPLVLNSGQG	KIAA2026	1916	Q5HYC2
NNYIVGNKPPKECGD	IGF1R	166	P08069
YLKSGNQKEGPLQPL	PCNX2	716	A6NKB5
GYLQKPLEGSNNFKP	MMP19	36	Q99542
KKAIAYGPGIEPQGN	FLNC	276	Q14315
ENGQKDVGSYQLPKG	NRIP1	306	P48552
PGGGLPQYHKIKDQL	MICAL1	41	Q8TDZ2
KQDGESYKNPGKPDG	JAM3	276	Q9BX67
GVKGYEEKLNGNLRP	GATAD2B	71	Q8WXI9
KLQVYEGGGQPPPQD	KIF18B	386	Q86Y91
QPKGKPIANGEAEVY	FADS2B	26	A8MWK0
KGLNSYKDPDNPGRI	KAT6A	66	Q92794
ELVTKPVGGNYGKQP	EIF3C	21	Q99613
PVGGNYGKQPLLLSE	EIF3C	26	Q99613
ELVTKPVGGNYGKQP	EIF3CL	21	B5ME19
PVGGNYGKQPLLLSE	EIF3CL	26	B5ME19
GPNKPGYLVGRNNAN	CPN1	141	P15169
EVPIPEGLNGQKKYQ	E2F4	166	Q16254
ADNQQGPGYIDIPKG	FAM135B	836	Q49AJ0
GQPRGNQLKGENYSP	C1QTNF7	16	Q9BXJ2
YETNKQPGLKPGLAG	FOCAD	821	Q5VW36
NPEAFQPKIGKGQLG	TESMIN	346	Q9Y4I5
GQEYKPGNPPAEIGQ	EPRS1	796	P07814
QKPGQAPVLVIYGKN	IGLV3-19	56	P01714
QAKYLGLNKNGPFKP	AHCYL1	511	O43865
RLQGQPGYFNKLEKP	MARCOL	71	A0A1B0GUY1
QENKGSGPQAYPKAL	RNF215	126	Q9Y6U7
GKFLNKNPVGPGKYV	RSPH1	161	Q8WYR4
YRLQGQKEPGDQGPA	MRPS2	271	Q9Y399
SGQNNKLLYGEPPKS	RASGRF1	716	Q13972
GGPDNLVLLNPEKYK	ADD1	336	P35611
DLLLGKKQNEYGPPG	CLCA4	136	Q14CN2
NKFYEGPENPGLGLL	TBC1D17	386	Q9HA65
KIRGQVKNPGYPQSE	SH3GL1	76	Q99961
VKNPGYPQSEGLLGE	SH3GL1	81	Q99961
QNQPNGGKLFPRKEG	ZNF671	211	Q8TAW3
DDLQGIQKIYGPPDK	MMP16	281	P51512
KIRGQEKGPGYPQAE	SH3GL2	76	Q99962
SGPGPGQYDIVQKKT	STPG2	156	Q8N412
KKPQDSQLEEGKPGY	PTK7	416	Q13308
EELSGNPGYQLGKPV	TCTN2	431	Q96GX1
KFQGPDNGQGPKYVK	TXNL1	181	O43396