Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of microtubule plus-end binding	MAPRE1 MAPRE3	8.89e-06	2	62	2	GO:1903033
GeneOntologyBiologicalProcess	regulation of microtubule plus-end binding	MAPRE1 MAPRE3	8.89e-06	2	62	2	GO:1903031
GeneOntologyBiologicalProcess	positive regulation of microtubule binding	MAPRE1 MAPRE3	8.84e-05	5	62	2	GO:1904528
GeneOntologyBiologicalProcess	regulation of asymmetric cell division	INSC ASPM	8.84e-05	5	62	2	GO:0009786
GeneOntologyCellularComponent	mitotic spindle astral microtubule end	MAPRE1 MAPRE3	2.68e-05	3	63	2	GO:1905721
GeneOntologyCellularComponent	microtubule end	MAPRE1 MAPRE3 ASPM	2.04e-04	38	63	3	GO:1990752
GeneOntologyCellularComponent	mitotic spindle astral microtubule	MAPRE1 MAPRE3	2.47e-04	8	63	2	GO:0061673
GeneOntologyCellularComponent	mitotic spindle	MAPRE1 MAPRE3 ASPM CEP295 WDR62	3.50e-04	201	63	5	GO:0072686
GeneOntologyCellularComponent	lipid droplet	RAB40AL BSCL2 RAB40B RAB40A	4.17e-04	116	63	4	GO:0005811
GeneOntologyCellularComponent	astral microtubule	MAPRE1 MAPRE3	4.83e-04	11	63	2	GO:0000235
GeneOntologyCellularComponent	aster	MAPRE1 MAPRE3	5.79e-04	12	63	2	GO:0005818
GeneOntologyCellularComponent	cell cortex	MAPRE1 INSC CSNK1G2 RYR1 PHLDB2 EXOC4	8.70e-04	371	63	6	GO:0005938
GeneOntologyCellularComponent	synaptic vesicle	RAB40AL RAB40B RAB40A MADD EXOC4	2.10e-03	300	63	5	GO:0008021
GeneOntologyCellularComponent	spindle microtubule	MAPRE1 MAPRE3 CEP295	2.23e-03	86	63	3	GO:0005876
Domain	EB1_C	MAPRE1 MAPRE3	3.14e-05	3	61	2	IPR004953
Domain	EB1_C	MAPRE1 MAPRE3	3.14e-05	3	61	2	PS51230
Domain	MAPRE	MAPRE1 MAPRE3	3.14e-05	3	61	2	IPR027328
Domain	EB1	MAPRE1 MAPRE3	3.14e-05	3	61	2	PF03271
Domain	SOCS	RAB40AL RAB40B RAB40A	3.63e-05	20	61	3	SM00253
Domain	SOCS_box	RAB40AL RAB40B RAB40A	2.58e-04	38	61	3	PF07525
Domain	SOCS_box	RAB40AL RAB40B RAB40A	2.79e-04	39	61	3	SM00969
Domain	SOCS	RAB40AL RAB40B RAB40A	2.79e-04	39	61	3	PS50225
Domain	SOCS_box	RAB40AL RAB40B RAB40A	2.79e-04	39	61	3	IPR001496
Domain	DH_1	ARHGEF26 ARHGEF17 SOS2	1.15e-03	63	61	3	PS00741
Domain	RhoGEF	ARHGEF26 ARHGEF17 SOS2	1.43e-03	68	61	3	SM00325
Domain	RhoGEF	ARHGEF26 ARHGEF17 SOS2	1.55e-03	70	61	3	PF00621
Domain	CH	MAPRE1 MAPRE3 ASPM	1.55e-03	70	61	3	PF00307
Domain	DH_2	ARHGEF26 ARHGEF17 SOS2	1.55e-03	70	61	3	PS50010
Domain	DH-domain	ARHGEF26 ARHGEF17 SOS2	1.62e-03	71	61	3	IPR000219
Domain	-	ARHGEF26 ARHGEF17 SOS2	1.62e-03	71	61	3	1.20.900.10
Domain	-	MAPRE1 MAPRE3 ASPM	1.62e-03	71	61	3	1.10.418.10
Domain	-	GAB3 ARHGEF26 ARHGEF17 FRMD4B PHLDB2 SOS2	1.70e-03	391	61	6	2.30.29.30
Domain	CH	MAPRE1 MAPRE3 ASPM	1.75e-03	73	61	3	PS50021
Domain	RAB	RAB40AL RAB40B RAB40A	1.75e-03	73	61	3	PS51419
Domain	CH-domain	MAPRE1 MAPRE3 ASPM	1.89e-03	75	61	3	IPR001715
Domain	PH_dom-like	GAB3 ARHGEF26 ARHGEF17 FRMD4B PHLDB2 SOS2	2.62e-03	426	61	6	IPR011993
Domain	ZnF_U1	ZFHX4 ZNF318	4.02e-03	29	61	2	SM00451
Domain	Znf_U1	ZFHX4 ZNF318	4.02e-03	29	61	2	IPR003604
Domain	ARM-type_fold	ARFGEF3 GPRASP1 INSC ASPM NIPBL	4.96e-03	339	61	5	IPR016024
Domain	-	GPRASP1 INSC ASPM NIPBL	5.97e-03	222	61	4	1.25.10.10
Domain	P-loop_NTPase	RAB40AL NAIP ASPM YTHDC2 SLFN11 RAB40B RAB40A RAD17	6.11e-03	848	61	8	IPR027417
Domain	PH	GAB3 ARHGEF26 PHLDB2 SOS2	6.65e-03	229	61	4	PF00169
Pubmed	Rab40b and Tks5 interact at invadopodia during metastasis.	RAB40AL RAB40B RAB40A	5.93e-08	5	64	3	27909076
Pubmed	Mammalian end binding proteins control persistent microtubule growth.	MAPRE1 MAPRE3	3.33e-06	2	64	2	19255245
Pubmed	Association of KIR2DL5B gene with celiac disease supports the susceptibility locus on 19q13.4.	KIR2DL5B KIR2DL5A	3.33e-06	2	64	2	17215859
Pubmed	Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B.	KIR2DL5B KIR2DL5A	3.33e-06	2	64	2	12185535
Pubmed	Tau regulates the localization and function of End-binding proteins 1 and 3 in developing neuronal cells.	MAPRE1 MAPRE3	3.33e-06	2	64	2	25761518
Pubmed	Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene.	KIR2DL5B KIR2DL5A	3.33e-06	2	64	2	11086080
Pubmed	Molecular analysis of 23 Pakistani families with autosomal recessive primary microcephaly using targeted next-generation sequencing.	ASPM WDR62	3.33e-06	2	64	2	27784895
Pubmed	EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms.	MAPRE1 MAPRE3	3.33e-06	2	64	2	21768326
Pubmed	Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics.	MAPRE1 MAPRE3	3.33e-06	2	64	2	24478452
Pubmed	Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules.	MAPRE1 MAPRE3	3.33e-06	2	64	2	18230754
Pubmed	End binding proteins are obligatory dimers.	MAPRE1 MAPRE3	3.33e-06	2	64	2	24040250
Pubmed	EB1 and EB3 regulate microtubule minus end organization and Golgi morphology.	MAPRE1 MAPRE3	3.33e-06	2	64	2	28814570
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	ZFHX4 ASPM NHS CEP295 MADD	6.64e-06	142	64	5	11812828
Pubmed	Molecular insights into mammalian end-binding protein heterodimerization.	MAPRE1 MAPRE3	9.99e-06	3	64	2	20008324
Pubmed	EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue.	MAPRE1 MAPRE3	9.99e-06	3	64	2	10644998
Pubmed	Angiotensin II type 1 receptor (AT-1R) expression correlates with VEGF-A and VEGF-D expression in invasive ductal breast cancer.	AGTR1 VEGFD	9.99e-06	3	64	2	22581182
Pubmed	Promoter variants of KIR2DL5 add to diversity and may impact gene expression.	KIR2DL5B KIR2DL5A	9.99e-06	3	64	2	18461314
Pubmed	MAP1B regulates microtubule dynamics by sequestering EB1/3 in the cytosol of developing neuronal cells.	MAPRE1 MAPRE3	9.99e-06	3	64	2	23572079
Pubmed	Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections.	KIR2DL5B KIR2DL5A	2.00e-05	4	64	2	22652695
Pubmed	KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains.	KIR2DL5B KIR2DL5A	2.00e-05	4	64	2	10820258
Pubmed	Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice.	TEKT3 CCDC38	2.00e-05	4	64	2	37709195
Pubmed	Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5.	KIR2DL5B KIR2DL5A	2.00e-05	4	64	2	18498296
Pubmed	Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes.	RAB40B RAB40A	2.00e-05	4	64	2	25661869
Pubmed	CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.	MAPRE1 MAPRE3	3.32e-05	5	64	2	15631994
Pubmed	Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice.	EFEMP2 AGTR1	3.32e-05	5	64	2	23636094
Pubmed	EB1 and EB3 control CLIP dissociation from the ends of growing microtubules.	MAPRE1 MAPRE3	3.32e-05	5	64	2	16148041
Pubmed	Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity.	MAPRE1 MAPRE3	3.32e-05	5	64	2	19146815
Pubmed	Characterization of functional domains of human EB1 family proteins.	MAPRE1 MAPRE3	3.32e-05	5	64	2	14514668
Pubmed	EB/RP gene family encodes tubulin binding proteins.	MAPRE1 MAPRE3	3.32e-05	5	64	2	10188731
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	ARFGEF3 KIDINS220 NHS YTHDC2 WDR62	4.27e-05	209	64	5	36779422
Pubmed	Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases.	MAPRE1 MAPRE3	4.98e-05	6	64	2	19696028
Pubmed	The SOCS box: a tale of destruction and degradation.	RAB40AL RAB40B RAB40A	6.03e-05	41	64	3	12076535
Pubmed	TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation.	MAPRE1 MAPRE3	9.27e-05	8	64	2	26323690
Pubmed	Evolution of the Rab family of small GTP-binding proteins.	RAB40B RAB40A	9.27e-05	8	64	2	11697911
Pubmed	MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.	MADD SOS2	1.19e-04	9	64	2	19289468
Pubmed	MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.	MAPRE1 MAPRE3	1.19e-04	9	64	2	23509069
Pubmed	Genome wide association study of age at menarche in the Japanese population.	ZFHX4 INSC	1.19e-04	9	64	2	23667675
Pubmed	iASPP-PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation.	MAPRE1 MAPRE3	1.19e-04	9	64	2	29743530
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	KIDINS220 NHS YTHDC2 ZNF318 EXOC4	1.26e-04	263	64	5	34702444
Pubmed	EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis.	MAPRE1 MAPRE3	1.49e-04	10	64	2	23001180
Pubmed	Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.	RAB40AL RAB40B RAB40A	1.71e-04	58	64	3	11856727
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ARFGEF3 FSIP2 NHS ARHGEF17 WDR62 PHLDB2 MADD EXOC4	1.78e-04	861	64	8	36931259
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZFHX4 ASPM YTHDC2 CEP295 ZNF318 SLFN11 UNC80 WDR62 PHLDB2	1.97e-04	1116	64	9	31753913
Pubmed	Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.	RAB40AL RAB40B RAB40A	1.98e-04	61	64	3	12578829
Pubmed	The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.	RAB40AL RAB40B RAB40A	2.08e-04	62	64	3	11773082
Pubmed	Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations.	KIR2DL5B KIR2DL5A	2.57e-04	13	64	2	19120281
Pubmed	Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.	ASPM WDR62	2.99e-04	14	64	2	27974163
Pubmed	Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.	RAB40AL RAB40B RAB40A	3.24e-04	72	64	3	16923123
Pubmed	Primary Autosomal Recessive Microcephalies and Seckel Syndrome Spectrum Disorders – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	ASPM WDR62	3.93e-04	16	64	2	20301772
Pubmed	Rab40-Cullin5 complex regulates EPLIN and actin cytoskeleton dynamics during cell migration.	RAB40B ARHGEF26	3.93e-04	16	64	2	33999101
Pubmed	[Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population].	KIR2DL5B KIR2DL5A	3.93e-04	16	64	2	16403292
Pubmed	[Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese].	KIR2DL5B KIR2DL5A	4.45e-04	17	64	2	19218127
Pubmed	Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.	KIR2DL5B KIR2DL5A	4.45e-04	17	64	2	20878400
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China.	KIR2DL5B KIR2DL5A	4.45e-04	17	64	2	20650299
Pubmed	Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease.	KIR2DL5B KIR2DL5A	4.45e-04	17	64	2	19450876
Pubmed	Distribution of killer-cell immunoglobulin-like receptor genes in Eastern mainland Chinese Han and Taiwanese Han populations.	KIR2DL5B KIR2DL5A	4.45e-04	17	64	2	19761533
Pubmed	Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly.	ASPM WDR62	5.00e-04	18	64	2	28272472
Pubmed	Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes.	KIR2DL5B KIR2DL5A	5.00e-04	18	64	2	20200544
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ARFGEF3 MAPRE1 ZFHX4 YTHDC2 PHLDB2	5.41e-04	361	64	5	26167880
Pubmed	HLA and KIR frequencies in Sicilian Centenarians.	KIR2DL5B KIR2DL5A	6.20e-04	20	64	2	20426625
Pubmed	Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay.	KIR2DL5B KIR2DL5A	6.20e-04	20	64	2	20193031
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	KIDINS220 CSNK1G2 ARHGEF26 NDRG3 PHLDB2 IGSF3	6.27e-04	569	64	6	30639242
Pubmed	A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).	GPRASP1 AGTR1	6.84e-04	21	64	2	15452121
Pubmed	Distribution of KIR genes in the population of unrelated individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3).	KIR2DL5B KIR2DL5A	7.52e-04	22	64	2	20492596
Pubmed	Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis.	RAB40B RAB40A	8.23e-04	23	64	2	20360680
Pubmed	Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.	ASPM CCDC38	8.23e-04	23	64	2	24925725
Pubmed	VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling.	ASPM WDR62	1.14e-03	27	64	2	21737879
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	H2BC1 YTHDC2 RAD17	1.30e-03	116	64	3	21282530
Pubmed	DULIP: A Dual Luminescence-Based Co-Immunoprecipitation Assay for Interactome Mapping in Mammalian Cells.	MAPRE1 MAPRE3 VEGFD	1.36e-03	118	64	3	26264872
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ARFGEF3 KIDINS220 NAIP ANKIB1 BSCL2 RAB40B ARHGEF26 EXOC4 SOS2	1.56e-03	1489	64	9	28611215
Pubmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.	FAM234A KIDINS220 NDRG3 PHLDB2 EXOC4	1.70e-03	467	64	5	30194290
Interaction	RAB40B interactions	EFEMP2 RAB40AL RAB40B ARHGEF26	3.11e-06	33	62	4	int:RAB40B
Interaction	RAB40AL interactions	RAB40AL RAB40B RAB40A	1.51e-05	16	62	3	int:RAB40AL
Interaction	CEP43 interactions	ARFGEF3 MAPRE1 MAPRE3 CEP295 SLFN11 EXOC4	2.57e-05	190	62	6	int:CEP43
Interaction	TRIM66 interactions	ASPM YTHDC2 CEP295 ZNF318 SLFN11 WDR62	3.94e-05	205	62	6	int:TRIM66
Cytoband	19p13.3	MIDN KIR2DL5B CSNK1G2 KIR2DL5A	3.45e-04	237	64	4	19p13.3
Cytoband	Xq22.1	GPRASP1 RAB40A	1.66e-03	43	64	2	Xq22.1
Cytoband	Ensembl 112 genes in cytogenetic band chrXq22	GPRASP1 RAB40AL RAB40A	1.82e-03	172	64	3	chrXq22
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF26 ARHGEF17 SOS2	3.30e-04	66	37	3	722
GeneFamily	CD molecules\|Killer cell immunoglobulin like receptors	KIR2DL5B KIR2DL5A	6.11e-04	18	37	2	620
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	GAB3 ARHGEF26 PHLDB2 SOS2	8.05e-04	206	37	4	682
GeneFamily	RAB, member RAS oncogene GTPases	RAB40B RAB40A	7.82e-03	65	37	2	388
Coexpression	GSE17721_LPS_VS_CPG_0.5H_BMDC_UP	PROZ ZFHX4 BSCL2 WDR62 RAD17 SOS2	8.18e-06	198	63	6	M3982
Coexpression	GSE8621_LPS_STIM_VS_LPS_PRIMED_AND_LPS_STIM_MACROPHAGE_DN	FAM234A REPS1 ASPM GAB3 TMEM43 ARHGEF26	8.66e-06	200	63	6	M6983
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 ASPM GAB3 NHS IGSF3	3.03e-06	161	62	5	9f02b94e29e60d50e92eaa748ebf0c36d3671bb3
ToppCell	primary_visual_cortex-Neuronal\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GPRASP1 MAPRE3 BSCL2 NDRG3 UNC80	7.89e-06	196	62	5	8efc2b3a95f57c31be203ac781b2098d4909297f
ToppCell	frontal_cortex-Neuronal\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GPRASP1 MAPRE3 BSCL2 NDRG3 UNC80	7.89e-06	196	62	5	de7d10da862f98894ce47244fbc992f4a12d63bb
ToppCell	LPS-antiTNF-Unknown-Endothelial-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	INSC AGTR1 ASPM WDR62	3.46e-05	132	62	4	02491930097b75aaeedab9e8200711b0dc610944
ToppCell	COVID-19_Mild-Neu_2\|World / 5 Neutrophil clusters in COVID-19 patients	ARFGEF3 GPRASP1 FAM234A UNC80	4.35e-05	140	62	4	b1429028c52f84127b894b93b55961badcd5246f
ToppCell	Mild/Remission-B_naive-1\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	BCLAF3 FAM234A PCNX1 ZNF318	4.73e-05	143	62	4	bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Ptgdr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NHS RXFP3 FRMD4B IGSF3	4.86e-05	144	62	4	71107275767a0728541a3695715c44874b3e5efc
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_3\|E16.5-samps / Age Group, Lineage, Cell class and subclass	YTHDC2 ZNF318 VEGFD SOS2	5.55e-05	149	62	4	651494e84be03dc7b061ebdfa91756a1c507b9b4
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_E\|390C / Donor, Lineage, Cell class and subclass (all cells)	ZBTB34 PROZ PCNX1 FAM227B	6.47e-05	155	62	4	98d8432739965dd1ab77c899cb6321f7f05eaa46
ToppCell	Control-Stromal-Pericyte\|Stromal / Disease state, Lineage and Cell class	INSC OBSCN-AS1 ARHGEF17 FRMD4B	7.14e-05	159	62	4	6f50c381cd8a26a5a90bf0ce909713cea96910d7
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|Myeloid_cells / Location, Cell class and cell subclass	FAM234A MIDN OBSCN-AS1 FAM200A	9.04e-05	169	62	4	dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCell	15-Trachea-Mesenchymal-Mesenchyme_RSPO2+\|Trachea / Age, Tissue, Lineage and Cell class	ASPM VEGFD MADD IGSF3	1.01e-04	174	62	4	fa0681e91724b9a51ee28b214ea5aa14e62ba1a3
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCLAF3 ZBTB34 RYR1 MADD	1.01e-04	174	62	4	ff13a5c55d18b951315908f33cb47c7f9cb901bf
ToppCell	nucseq-Epithelial-Epithelial_Airway-Secretory/RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARFGEF3 PIGR INSC NHS	1.08e-04	177	62	4	779ba86f53650772755b52460be03f18bb204e55
ToppCell	nucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARFGEF3 PIGR INSC NHS	1.08e-04	177	62	4	0f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCell	Adult-Epithelial-lung_goblet_cell\|Adult / Lineage, Cell type, age group and donor	ARFGEF3 PIGR INSC NHS	1.13e-04	179	62	4	1fc1f252ca943a2f649d1e627f56acbf15f8e058
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-1\|TCGA-Adrenal / Sample_Type by Project: Shred V9	GPRASP1 KIDINS220 BSCL2 UNC80	1.13e-04	179	62	4	431e1b29015ec817f778499106d24b19cfc825ae
ToppCell	normal_Lung-Fibroblasts-Pericytes\|normal_Lung / Location, Cell class and cell subclass	INSC EFEMP2 AGTR1 ARHGEF17	1.18e-04	181	62	4	f74941e49950027360d71ea3b205fc20c6929766
ToppCell	343B-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CSNK1G2 YTHDC2 FAM227B BSCL2	1.28e-04	185	62	4	02cbf492bc40abebaa93a3a208888afae72fbe06
ToppCell	343B-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CSNK1G2 YTHDC2 FAM227B BSCL2	1.28e-04	185	62	4	1b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	INSC AGTR1 ARHGEF17 FRMD4B	1.36e-04	188	62	4	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	COPD-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	ARFGEF3 PIGR ASPM PHLDB2	1.36e-04	188	62	4	186fe1ea328c942910190a4240262c0d8642ea3b
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	INSC EFEMP2 AGTR1 ARHGEF17	1.51e-04	193	62	4	41ea268e7697101fe70d8ef1045f3a43b9311739
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	INSC EFEMP2 AGTR1 ARHGEF17	1.51e-04	193	62	4	b2abe939027a69b60d83a28d4d4cc53ba1dee4c5
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	INSC EFEMP2 AGTR1 ARHGEF17	1.51e-04	193	62	4	87ce81ff5b27d9c4300826d76ff5a62e9c408d5d
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	INSC EFEMP2 AGTR1 ARHGEF17	1.51e-04	193	62	4	d75f334fe3d9f39ef02a5de0f8202f7a761a8fc8
ToppCell	PSB-critical-LOC-Epithelial-FOXN4+\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ASPM CEP295 SLFN11 WDR62	1.51e-04	193	62	4	b7d9c5bed524423e92f01496a9f8fad11b33a3f7
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NAIP GAB3 FRMD4B RYR1	1.54e-04	194	62	4	1dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	INSC EFEMP2 AGTR1 ARHGEF17	1.54e-04	194	62	4	3cffb5c58f6d5bd254f39ee9c41b7e1e4da0ff75
ToppCell	moderate-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ASPM CEP295 SLFN11 WDR62	1.54e-04	194	62	4	dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GPRASP1 NDRG3 UNC80 MADD	1.54e-04	194	62	4	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	3'-Distal_airway-Mesenchymal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	INSC EFEMP2 AGTR1 ARHGEF17	1.54e-04	194	62	4	f5e3e675187afb6efa774f2a8d685efcf813de82
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	GPRASP1 EFEMP2 NHS ARHGEF17	1.57e-04	195	62	4	5562665dd3beb70e2358aa32611a337bef5731c1
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 ARHGEF17 UNC80 MADD	1.57e-04	195	62	4	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NAIP GAB3 FRMD4B RYR1	1.57e-04	195	62	4	34a9462f4e843f3065cc58c17ad71c1b5b836ae1
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	INSC EFEMP2 AGTR1 ARHGEF17	1.60e-04	196	62	4	c373465e34e2dd581247962d59e0477aae877079
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	INSC EFEMP2 AGTR1 ARHGEF17	1.60e-04	196	62	4	9d18381d7aaa063094a5df769a04c73350471525
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	INSC EFEMP2 AGTR1 ARHGEF17	1.60e-04	196	62	4	8b5337ccf74de90e8b89a02ac00671af1de2cfff
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	INSC EFEMP2 AGTR1 ARHGEF17	1.60e-04	196	62	4	a52cb512c6173be92aa9c4d96e2abbc32f45478d
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	INSC EFEMP2 AGTR1 ARHGEF17	1.60e-04	196	62	4	afddacc0fb8b9c73dad5333137deb471a6ebdc06
ToppCell	Bronchial-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Mucous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ARFGEF3 PIGR NXPE2 ITIH6	1.69e-04	199	62	4	eb2d1b7e875c5bf833e7a80b43282e12893c34e9
ToppCell	distal-mesenchymal-Pericyte-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	INSC EFEMP2 AGTR1 ARHGEF17	1.69e-04	199	62	4	000d9b5f5a48e56f0733390adb3d7270c49a4a1a
ToppCell	medial-mesenchymal-Pericyte-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	INSC EFEMP2 AGTR1 ARHGEF17	1.73e-04	200	62	4	bbda454260016be92b539e220ecf7bcbbc6139e4
ToppCell	proximal-3-mesenchymal-Pericyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	INSC EFEMP2 AGTR1 ARHGEF17	1.73e-04	200	62	4	98cbd0f4994e645f70c0bc5ebc1c3a3b28c6b67f
ToppCell	distal-3-mesenchymal-Pericyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	INSC EFEMP2 AGTR1 ARHGEF17	1.73e-04	200	62	4	911db29f254bb697610e720ba78816e2c7f57933
ToppCell	medial-mesenchymal-Pericyte\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	INSC EFEMP2 AGTR1 ARHGEF17	1.73e-04	200	62	4	f36d7cb6345daccebf76997f998e35d959b59452
ToppCell	distal-mesenchymal-Pericyte\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	INSC EFEMP2 AGTR1 ARHGEF17	1.73e-04	200	62	4	fe31287cfb51d45643bdedbaa5efc03ed87263c6
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	ZFHX4 INSC EFEMP2 GAB3	1.73e-04	200	62	4	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	proximal-mesenchymal-Pericyte\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	INSC EFEMP2 AGTR1 ARHGEF17	1.73e-04	200	62	4	03119a979bc912a98e6fc87addcbc25d8ecf2fb0
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Interneuron\|10w / Sample Type, Dataset, Time_group, and Cell type.	KIDINS220 ZFHX4 FRMD4B IGSF3	1.73e-04	200	62	4	f5c63ef52bd7a898cf009b8bf9b2f7f4890d1c9b
ToppCell	medial-2-mesenchymal-Pericyte\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	INSC EFEMP2 AGTR1 ARHGEF17	1.73e-04	200	62	4	9820fb4f6efcdfc6de937ef2302a98b48426baa3
ToppCell	proximal-mesenchymal-Pericyte-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	INSC EFEMP2 AGTR1 ARHGEF17	1.73e-04	200	62	4	a81fde3d40b8efb3be535aeb2a44cfbdeb17bc8b
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Nfib_(Amygdala)-\|Striatum / BrainAtlas - Mouse McCarroll V32	FAM227B RXFP3 ZNF791	2.04e-04	82	62	3	1ca848a18463b1344e23e3ad1b5d01ae27c00586
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Nfib_(Amygdala)\|Striatum / BrainAtlas - Mouse McCarroll V32	FAM227B RXFP3 ZNF791	2.04e-04	82	62	3	ab081620b6113f843fede23da0a18720111ffc7c
Disease	Oligospermia	BSCL2 PIWIL3	2.47e-04	12	58	2	C0028960
Disease	Autosomal recessive primary microcephaly	ASPM WDR62	3.92e-04	15	58	2	cv:C3711387
Disease	primary autosomal recessive microcephaly (is_implicated_in)	ASPM WDR62	4.48e-04	16	58	2	DOID:0070296 (is_implicated_in)
Disease	food allergy measurement, parental genotype effect measurement	PROZ RNASE11	5.69e-04	18	58	2	EFO_0005939, EFO_0007016
Disease	Primary microcephaly	ASPM WDR62	8.55e-04	22	58	2	C0431350
Disease	Autosomal Recessive Primary Microcephaly	ASPM WDR62	8.55e-04	22	58	2	C3711387
Disease	microcephaly (implicated_via_orthology)	ASPM WDR62	1.81e-03	32	58	2	DOID:10907 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
YTSASFRHMSLLDIS	NAIP	411	Q13075
ESRLSRLATKSHYSS	FAM227B	361	Q96M60
TTRRMLSHSSGAVRY	FAM234A	316	Q9H0X4
SHSNLSTKMSTLSYR	AGTR1	326	P30556
SSASMSVLHSSSLRD	ANKIB1	816	Q9P2G1
STMLYSRQSSASHLF	ARHGEF26	731	Q96DR7
SRSTTMNERALLSSY	FAM200A	51	Q8TCP9
SMHSSATLIQSRFRS	ASPM	2406	Q8IZT6
MRGLSYSLTTSSTHK	RAB40A	236	Q8WXH6
YSLTTSSTHKRSSLR	RAB40B	241	Q12829
MRGLSYSLTTSSTHK	RAB40AL	236	P0C0E4
REYSTSIATRGVMHS	RAD17	491	O75943
TLSCSSRSSFDMYHL	KIR2DL5A	141	Q8N109
HMRRSESTYSVNSTG	KIAA0895L	76	Q68EN5
SLRRSSMSLYTAASV	ARHGEF17	1326	Q96PE2
MTRLARSRTHSTSSS	NDRG3	321	Q9UGV2
SMTHKRSQRSSYTRL	KIDINS220	1731	Q9ULH0
IMSFASSLYRNHSTS	MADD	846	Q8WXG6
YIEMEEHRTASSLSS	GAB3	506	Q8WWW8
SLTGTARYMSINTHL	CSNK1G2	211	P78368
SLPRSSSDYSTMLSH	FSIP2	4126	Q5CZC0
TLSCSSRSSFDMYHL	KIR2DL5B	141	Q8NHK3
YSSRHSSLRMSTTGF	PCNX1	2131	Q96RV3
ESSSALCSHLYSMIR	NIPBL	2386	Q6KC79
TRQSREMLSTHSSPY	FRMD4B	636	Q9Y2L6
ASEASRLAHYSKRST	H2BC1	76	Q96A08
SSSHAISMSAYLREQ	EXOC4	446	Q96A65
ISLSRDFMLHSSSEY	IGSF3	196	O75054
VASSYSTERQMSHDL	BCLAF3	426	A2AJT9
SSSSSMHLHRRFTDL	ARFGEF3	241	Q5TH69
YSTSVTSDNLSRHDM	MAPRE1	6	Q15691
YSTSVTSENLSRHDM	MAPRE3	6	Q9UPY8
SMRSTVVSRYAHTLV	ITIH6	41	Q6UXX5
TFSSRMKSHSYLSQL	CCDC38	61	Q502W7
RLTCHARSMVSEYSA	INSC	156	Q1MX18
SSIVHRYMTITSERS	EFEMP2	341	O95967
STSSRSVMLHYRSDL	BSCL2	141	Q96G97
YFTALRRTSMHSSLN	CEP295	2126	Q9C0D2
LILYSRSSHREAMSL	PIWIL3	511	Q7Z3Z3
MSSTLLTFRSLHYND	RNASE11	71	Q8TAA1
AHSRMYLSCLTTSRS	RYR1	111	P21817
MYTASSSAETLRTVR	OBSCN-AS1	1	Q96MR7
MSLAIHSTTGTRYDL	MIDN	31	Q504T8
SGIRMIRHLTTTTDY	GPRASP1	1256	Q5JY77
MSVTRYHSVASALKS	RXFP3	176	Q9NSD7
MAANYSSTSTRREHV	TMEM43	1	Q9BTV4
SHSRSSSLDMNRTFT	REPS1	556	Q96D71
SLHYRSTLDRMLDSV	SOS2	541	Q07890
SRSDSSYRMSATEIL	NHS	1526	Q6T4R5
LTHMTTRTRNISYLS	NXPE2	266	Q96DL1
SLYRRSETSVRSMDS	SLFN11	131	Q7Z7L1
ISTMASSYRDRFPHS	TEKT3	26	Q9BXF9
TTRTYCERSSVAAMH	PROZ	336	P22891
LRTRKYSSSSLSHMG	PHLDB2	236	Q86SQ0
AYSQSSTLEIHMRSV	ZFHX4	1556	Q86UP3
RLSSLTRHMRSHTGY	ZNF791	111	Q3KP31
TSTSAYRLSLATMSR	UNC80	2926	Q8N2C7
SSRSHTSLYMSELIQ	ZNF577	391	Q9BSK1
YSHFMTSKVTRLSSL	TTC41P	121	Q6P2S7
RVSIRSYRTDISMSD	PIGR	671	P01833
SYMEATASSRARISR	WDR62	1211	O43379
YRHSETSATALMVAA	YTHDC2	501	Q9H6S0
LKSFTSMDSRSASHR	VEGFD	71	O43915
MYRSSARSSVSSHRP	ZNF318	1	Q5VUA4
YFRDHSALSTMSGLS	ZBTB34	56	Q8NCN2