Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of nuclear pore

POM121 POM121C POM121B

1.29e-0425793GO:0017056
GeneOntologyMolecularFunctionnuclear localization sequence binding

POM121 POM121C POM121B

1.63e-0427793GO:0008139
DomainDUF4208

CHD1 CHD2

4.51e-053732PF13907
DomainTECPR

TECPR2 HERC2

4.51e-053732SM00706
DomainDUF4208

CHD1 CHD2

4.51e-053732SM01176
DomainBeta-propeller_rpt_TECPR

TECPR2 HERC2

4.51e-053732IPR006624
DomainDUF4208

CHD1 CHD2

4.51e-053732IPR025260
DomainRCC1/BLIP-II

TECPR2 HERC2 HERC1

9.59e-0523733IPR009091
DomainHECT

UBE3B HERC2 HERC1

1.57e-0427733PF00632
DomainHECTc

UBE3B HERC2 HERC1

1.57e-0427733SM00119
DomainHECT_dom

UBE3B HERC2 HERC1

1.57e-0427733IPR000569
DomainHECT

UBE3B HERC2 HERC1

1.57e-0427733PS50237
DomainCYTOCHROME_B5_2

HERC2 CYB5R4

1.14e-0313732PS50255
DomainCYTOCHROME_B5_1

HERC2 CYB5R4

1.14e-0313732PS00191
DomainCyt-b5

HERC2 CYB5R4

1.33e-0314732PF00173
DomainCyt_B5-like_heme/steroid-bd

HERC2 CYB5R4

1.33e-0314732IPR001199
DomainCyt-b5

HERC2 CYB5R4

1.33e-0314732SM01117
Domain-

HERC2 CYB5R4

1.33e-03147323.10.120.10
DomainChromodomain_CS

CHD1 CHD2

2.21e-0318732IPR023779
DomainRCC1

HERC2 HERC1

2.74e-0320732PF00415
DomainRCC1_1

HERC2 HERC1

3.02e-0321732PS00625
DomainRCC1_2

HERC2 HERC1

3.02e-0321732PS00626
DomainRCC1_3

HERC2 HERC1

3.02e-0321732PS50012
DomainReg_chr_condens

HERC2 HERC1

3.31e-0322732IPR000408
Domain-

HERC2 HERC1

3.31e-03227322.130.10.30
Domainfn3

COL12A1 TNC L1CAM FNDC4

3.73e-03162734PF00041
DomainChromo_domain

CHD1 CHD2

3.93e-0324732IPR023780
DomainWD40_repeat

DNAI1 TECPR2 HERC2 HERC1 LYST

4.24e-03272735IPR001680
DomainChromo

CHD1 CHD2

4.61e-0326732PF00385
DomainWD_REPEATS_1

DNAI1 TECPR2 HERC2 HERC1 LYST

4.64e-03278735PS00678
DomainWD_REPEATS_2

DNAI1 TECPR2 HERC2 HERC1 LYST

4.71e-03279735PS50082
DomainWD_REPEATS_REGION

DNAI1 TECPR2 HERC2 HERC1 LYST

4.71e-03279735PS50294
DomainCHROMO_1

CHD1 CHD2

5.33e-0328732PS00598
DomainCHROMO_2

CHD1 CHD2

5.33e-0328732PS50013
DomainFN3

COL12A1 TNC L1CAM FNDC4

5.96e-03185734SM00060
DomainWD40_repeat_dom

DNAI1 TECPR2 LRRK1 HERC1 LYST

6.12e-03297735IPR017986
DomainSNF2_N

CHD1 CHD2

6.93e-0332732IPR000330
DomainChromodomain-like

CHD1 CHD2

6.93e-0332732IPR016197
DomainSNF2_N

CHD1 CHD2

6.93e-0332732PF00176
DomainChromo/shadow_dom

CHD1 CHD2

7.36e-0333732IPR000953
DomainCHROMO

CHD1 CHD2

7.36e-0333732SM00298
DomainFN3

COL12A1 TNC L1CAM FNDC4

7.68e-03199734PS50853
DomainEF-hand_8

EFCAB6 RYR1

7.80e-0334732PF13833
Pubmed

POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation.

POM121 POM121C POM121B

1.22e-08381330802453
Pubmed

Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.

POM121 POM121C POM121B

1.22e-08381335507432
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NHSL1 UBE3B L1CAM INTS1 TRMT11 STEAP3 FRYL LRRK1 HERC2 HERC1 POM121C LYST CDC14B ADAT1 RYR1

3.54e-081105811535748872
Pubmed

Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes.

POM121 POM121C POM121B

4.86e-08481317900573
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

GIMAP4 AFAP1L2 VPS13A GLUL HERC2 POM121C LYST UNC80 RYR1 NOVA1

6.40e-07552811010737800
Pubmed

Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes.

FOXP2 L1CAM RPL7

1.44e-061081326245956
Pubmed

CHD1 and CHD2 are positive regulators of HIV-1 gene expression.

CHD1 CHD2

5.36e-06281225297984
Pubmed

Genetic control of glucuronidase induction in mice.

GUSB VPS33A

5.36e-0628124777306
Pubmed

The E3 ubiquitin ligase HERC1 controls the ERK signaling pathway targeting C-RAF for degradation.

RAF1 HERC1

5.36e-06281230140388
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

POM121 POM121C POM121B

5.43e-061581314697343
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

TNC GLUL LRRK1 HERC2 HERC1 RPL7 SLC39A7 UNC80

6.31e-0642081828065597
Pubmed

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

CENPF ZNF644 CCDC77 POLK POM121C

7.92e-0611681530804394
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

RAF1 TTBK1 VRK3 PACSIN3 CHD1 FRYL ACOT2 LRRK1 HERC2 HERC1 ACTR2 SLC39A7 ALPI

8.11e-061284811317353931
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

AFAP1L2 CENPF INTS1 VPS13A ZC2HC1C DGKH CHD2 ZNF831 RPL7 RYR1

8.23e-06736811029676528
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

RAF1 CENPF ZNF644 VPS13A TRMT11 CCT4 DGKH ACOT2 CKAP2 HERC2 HERC1 CCDC77 ACTR2 RPL7

8.55e-061496811432877691
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

ZNF644 CHD1 MCM10 CCDC77 POLK KAT14

1.38e-0522281637071664
Pubmed

Tenascin-C in the cochlea of the developing mouse.

TNC L1CAM

1.60e-05381210102501
Pubmed

CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis.

CCP110 AGBL5

1.60e-05381237226238
Pubmed

Coordinated regulation of XPA stability by ATR and HERC2 during nucleotide excision repair.

ATR HERC2

1.60e-05381223178497
Pubmed

Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes the EMT and cervical lymph node metastasis of oral squamous cell carcinoma.

ADAMTS1 L1CAM

1.60e-05381238263290
Pubmed

Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization.

RAF1 DGKH

1.60e-05381219710016
Pubmed

CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage.

CHD1 CHD2

1.60e-05381233022763
Pubmed

SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.

ZNF644 INTS1 CHD2 MCM10 RPL7

2.75e-0515081530154076
Pubmed

Characterization of the CHD family of proteins.

CHD1 CHD2

3.20e-0548129326634
Pubmed

EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole.

CCP110 HERC2

3.20e-05481237074924
Pubmed

HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability.

ATR HERC2

3.20e-05481225326330
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

MPP1 CCP110 PPP2R5D GUSB STEAP3 CHD1 CKAP2 MCM10 USP1

5.27e-0573381934672954
Pubmed

Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth.

TNC L1CAM

5.33e-05581212700241
Pubmed

Differential expression of phosphacan/RPTPbeta isoforms in the developing mouse visual system.

TNC L1CAM

5.33e-05581217722031
Pubmed

Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s).

POM121 POM121C POM121B

7.55e-053581311013070
Pubmed

Digital quantification of human eye color highlights genetic association of three new loci.

HERC2 LYST

7.99e-05681220463881
Pubmed

Mitochondrial malate dehydrogenase (Mor-1) in the mouse: linkage to chromosome 5 markers.

GUSB VPS33A

7.99e-0568121203052
Pubmed

ANG II type 2 receptor regulates smooth muscle growth and force generation in late fetal mouse development.

MYOCD ACTR2

7.99e-05681215331365
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

POM121 POM121C POM121B

9.68e-053881312791264
Pubmed

Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.

POM121 POM121C POM121B

9.68e-053881311779826
Pubmed

miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.

CCP110 ACTR2

1.12e-04781222684256
Pubmed

The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.

HERC2 HERC1

1.12e-0478129949213
Pubmed

Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome.

TNC RP1

1.12e-04781211767049
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

RYBP CCP110 INTS1 NAP1L4 CHD1 CHD2 ZNF831

1.14e-0446981727634302
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

RAF1 VPS13A CHD2 RP1 RYR1

1.29e-0420881533230847
Pubmed

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.

COL12A1 ADAMTS1 TNC PACSIN3 ALPI

1.35e-0421081516537572
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

CENPF INTS1 CHD1 CHD2 FRYL HERC2 ACTR2 RPL7

1.43e-0465381822586326
Pubmed

Temporal regulation of axonal repulsion by alternative splicing of a conserved microexon in mammalian Robo1 and Robo2.

L1CAM NOVA1

1.49e-04881231392959
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

NHSL1 PPP2R5D VPS13A CCT4 CKAP2 HERC2 HERC1 CCDC77 USP1 CDC14B

1.61e-041049811027880917
Pubmed

Tenascin C regulates proliferation and differentiation processes during embryonic retinogenesis and modulates the de-differentiation capacity of Müller glia by influencing growth factor responsiveness and the extracellular matrix compartment.

TNC GLUL

1.91e-04981222691363
Pubmed

Reciprocal Connections Between Cortex and Thalamus Contribute to Retinal Axon Targeting to Dorsal Lateral Geniculate Nucleus.

FOXP2 L1CAM

1.91e-04981228334242
Pubmed

Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes.

RAF1 PPP2R5D

1.91e-04981216239230
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

CCP110 COL12A1 VRK3 EFCAB6 TECPR2 TNC GUSB CD101 VPS33A CDC14B RYR1

2.01e-041293811115342556
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

RYBP VRK3 ATR CENPF ZNF644 INTS1 CHD2 CKAP2 POM121C KAT14 RPL7

2.02e-041294811130804502
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

NHSL1 COL12A1 AFAP1L2 VRK3 INTS1 PACSIN3 MCM10 CCDC77

2.05e-0468981836543142
Pubmed

Proteolytic cleavage of transmembrane cell adhesion molecule L1 by extracellular matrix molecule Reelin is important for mouse brain development.

FOXP2 L1CAM

2.38e-041081229127326
Pubmed

Widespread neuronal ectopia associated with secondary defects in cerebrocortical chondroitin sulfate proteoglycans and basal lamina in MARCKS-deficient mice.

TNC L1CAM

2.38e-04108129184108
Pubmed

Expression of Leukaemia associated transcription factor Af9/Mllt3 in the cerebral cortex of the mouse.

L1CAM AFF1

2.38e-041081219000783
Pubmed

Recruitment and maintenance of tendon progenitors by TGFbeta signaling are essential for tendon formation.

COL12A1 TNC

2.38e-041081219304887
Pubmed

Development of migrating tendon-bone attachments involves replacement of progenitor populations.

COL12A1 TNC

2.38e-041081230504126
Pubmed

Linx mediates interaxonal interactions and formation of the internal capsule.

FOXP2 L1CAM

2.91e-041181224930700
Pubmed

LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome.

CCP110 CENPF

2.91e-041181211163258
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

CENPF TRMT11 CHD1 MSH5 HERC2

3.03e-0425081533536335
Pubmed

Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.

PPP2R5D ATR UBE3B

3.42e-045881331067491
Pubmed

Gene expression in the developing mouse retina by EST sequencing and microarray analysis.

AFF1 CCT4 DGKH FRYL

3.47e-0414281411812828
Pubmed

HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.

ATR USP1

3.48e-041281224005329
Pubmed

Rheb binds and regulates the mTOR kinase.

RAF1 ATR

3.48e-041281215854902
Pubmed

Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex.

FOXP2 L1CAM

3.48e-041281225037921
Pubmed

Ran binding protein 9 interacts with Raf kinase but does not contribute to downstream ERK1/2 activation in skeletal myoblasts.

RAF1 PACSIN3

3.48e-041281216364241
Pubmed

TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors.

TNC ALPI

3.48e-041281231289197
Pubmed

Mouse rump-white mutation associated with an inversion of chromosome 5.

GUSB VPS33A

3.48e-04128128043948
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

POM121 SH3GL1 NAP1L4 CCDC77 POM121C

3.82e-0426381534702444
Pubmed

FISH mapping of three ammonia metabolism genes (Glul, Cps1, Glud1) in rat, and the chromosomal localization of GLUL in human and Cps1 in mouse.

GLUL ALPI

4.11e-04138129107685
Pubmed

A global gene regulatory program and its region-specific regulator partition neurons into commissural and ipsilateral projection types.

FOXP2 L1CAM

4.11e-041381238781326
Pubmed

Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.

ADAMTS1 MCM10 SLC39A7

4.17e-046281317975119
Pubmed

Gene variants associated with ischemic stroke: the cardiovascular health study.

ADAMTS1 MCM10 SLC39A7

4.37e-046381319023099
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

RAF1 NHSL1 HDAC11 TNC SH3GL1 L1CAM GLUL CCT4 ACTR2 RPL7 SLC39A7

4.75e-041431811137142655
Pubmed

Mutation of the BiP/GRP78 gene causes axon outgrowth and fasciculation defects in the thalamocortical connections of the mammalian forebrain.

FOXP2 L1CAM

4.79e-041481222821687
Pubmed

NOVA2-mediated RNA regulation is required for axonal pathfinding during development.

L1CAM NOVA1

4.79e-041481227223325
Pubmed

Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system.

FOXP2 L1CAM

4.79e-041481215964824
Pubmed

The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.

UBE3B L1CAM

4.79e-041481232249816
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

PPP2R5D ZNF644 VPS33A INTS1 NAP1L4

5.24e-0428281523667531
Pubmed

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

AFAP1L2 VPS33A ZC2HC1C CHD2 RP1

5.41e-0428481529459677
Pubmed

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.

MPP1 PPP2R5D NAP1L4 STEAP3

5.45e-0416081431678930
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

VRK3 ZNF644 INTS1 CHD1 CHD2 HERC2 MCM10

5.48e-0460881736089195
Pubmed

The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.

ATR USP1

5.52e-041581219536649
Pubmed

Iris phenotypes and pigment dispersion caused by genes influencing pigmentation.

VPS33A LYST

5.52e-041581218715234
Pubmed

Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).

SH3GL1 PACSIN3

5.52e-041581225036101
Pubmed

Villus myofibroblasts are developmental and adult progenitors of mammalian gut lymphatic musculature.

FOXP2 TNC

5.52e-041581238537630
Pubmed

Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci.

VPS33A LYST

5.52e-04158126696991
Pubmed

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.

FOXP2 HERC2 ACTR2

6.21e-047181329346117
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

POM121 CENPF INTS1 PACSIN3 CCT4 CHD1 HERC2 ACTR2 RPL7

6.28e-04102481924711643
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

PPP2R5D GUSB ZNF644 VPS13A NAP1L4 STEAP3 CHD1 CKAP2 HERC2 CCDC77 RPL7

6.53e-041487811133957083
Pubmed

Slit2 activity in the migration of guidepost neurons shapes thalamic projections during development and evolution.

FOXP2 L1CAM

7.12e-041781221435555
Pubmed

Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4.

UMOD MYOCD

7.12e-041781218776146
Pubmed

Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex.

FOXP2 L1CAM

7.12e-041781218940588
Pubmed

Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling.

FOXP2 NOVA1

7.12e-041781220620871
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

PPP2R5D ADAMTS1 NAP1L4 CCT4 DGKH HERC2 RPL7

7.34e-0463981723443559
Pubmed

Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.

FOXP2 L1CAM

8.00e-041881222090513
Pubmed

Involvement of Atm and Trp53 in neural cell loss due to Terf2 inactivation during mouse brain development.

ATR FOXP2

8.00e-041881228620865
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

PPP2R5D SH3GL1 NAP1L4 CCT4 CKAP2 HERC2 CCDC77 RPL7

8.42e-0485381828718761
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

COL12A1 PPP2R5D GUSB L1CAM VPS33A TRMT11 CCT4 ACTR2 SLC39A7 ALPI

8.54e-041297811033545068
Pubmed

Bioinformatics and cellular signaling.

RAF1 CCP110 SLC39A7 RYR1

8.82e-0418281415102471
Pubmed

Functional specialization of beta-arrestin interactions revealed by proteomic analysis.

ATR CENPF MYOCD DGKH RPL7

8.87e-0431781517620599
Pubmed

Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections.

FOXP2 L1CAM

8.93e-041981223395374
Cytoband7q11.23

POM121 POM121C POM121B

6.68e-04978037q11.23
CytobandEnsembl 112 genes in cytogenetic band chr7q11

POM121 GUSB POM121C POM121B

1.32e-03271804chr7q11
Cytoband16p12.3

CCP110 UMOD

1.62e-033480216p12.3
GeneFamilyFibronectin type III domain containing

COL12A1 TNC L1CAM FNDC4

7.22e-04160464555
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

GIMAP4 ATR ZNF644 CD101 NAP1L4 CCT4 CHD1 CHD2 FRYL CKAP2 HERC1 ZNF831 USP1 LYST ACTR2 RPL7

9.48e-0614928016M40023
CoexpressionAtlasfacebase_RNAseq_e10.5_MaxArch_2500_K3

MPP1 CCP110 HDAC11 VRK3 ATR FOXP2 CENPF ZNF644 VPS13A AFF1 CHD1 MCM10 CCDC77 USP1 CDC14B KAT14 ADAT1

1.57e-0612527617facebase_RNAseq_e10.5_MaxArch_2500_K3
ToppCellMesenchymal-myofibroblast_cell|World / Lineage, Cell type, age group and donor

COL12A1 ADAMTS1 TNC MYOCD UNC80 NOVA1

1.18e-0618980644e37f88137bb249933eb615235b2cf2ae7f3925
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

COL12A1 ADAMTS1 TNC L1CAM MYOCD

9.74e-061588058d64c0c9de910a3f4658778642d183c8b9b6f6a2
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP4 ATR ACOT2 POLK CDC14B

1.31e-05168805182f08106ac65ea501e2fb9139d3b44b7c4662c9
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP40 FOXP2 ADAMTS1 DGKH RP1

1.47e-051728050c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP40 FOXP2 ADAMTS1 DGKH RP1

1.47e-05172805eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL12A1 CENPF TNC CKAP2 CCDC77

1.60e-05175805a154b28b0b2180652d51d4c7d804b3b81b35899e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL12A1 FOXP2 CENPF TNC LRRK1

1.78e-05179805b35a7f8115c997c390201da01d7cb10b10769aec
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HDAC11 CENPF CKAP2 MCM10 ZNF831

1.78e-051798054166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL12A1 FOXP2 CENPF TNC LRRK1

2.03e-051848059cc5c588f7c6631b3fb8a522214a09ca32947e72
ToppCellmoderate-Lymphoid-NK|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

COL12A1 ADAMTS1 TNC FNDC4 NOVA1

2.09e-051858054979a787acbc9b4ca8defe91cc79b674e51af1bf
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL12A1 FOXP2 CENPF TNC LRRK1

2.09e-05185805a1b2525da018abe458908cab7268bd403ee98d92
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL12A1 ADAMTS1 TNC MYOCD UNC80

2.20e-05187805c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AFAP1L2 CENPF CKAP2 MCM10 CCDC77

2.20e-05187805057569c9437219ecc396aa6e673b1178a2273837
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

ZNF644 CHD1 DGKH CHD2 HERC1

2.25e-05188805ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellmoderate-Lymphoid-NK|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

COL12A1 ADAMTS1 TNC FNDC4 NOVA1

2.31e-0518980522a19365782003c18ec8dddcdbfdaa82c4e330f6
ToppCellCaecum-Dendritic_cell-cycling_DCs|Dendritic_cell / Region, Cell class and subclass

MPP1 GIMAP4 CENPF GLUL NCF4

2.37e-0519080554463f6f1718f22704175bd034f134de3b55d2eb
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CENPF TNC CKAP2 MCM10 RYR1

2.43e-051918050f9443da0f73d07456142fae08b2dc92a5b7b592
ToppCellLA-14._Fibroblast_III|World / Chamber and Cluster_Paper

COL12A1 FOXP2 TNC CHD1 NOVA1

2.62e-05194805803fa83ceada17c38ca9f933b888f7e7b0b90761
ToppCell5'-Adult-Appendix-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL12A1 ADAMTS1 GLUL FNDC4 NOVA1

2.82e-05197805b11a5d909942a4299cbc0b27332b1a3f66f3bccd
ToppCellLPS_only-Endothelial-Endothelial-FOXM1|LPS_only / Treatment groups by lineage, cell group, cell type

CCP110 CENPF RP1 CKAP2 RYR1

2.82e-05197805038fd92750257d43d5e980fd06d77742b543f11a
ToppCell390C-Fibroblasts-Fibroblast-K_(Pericytes)|390C / Donor, Lineage, Cell class and subclass (all cells)

COL12A1 ADAMTS1 TNC FNDC4 MYOCD

2.89e-05198805c82a151f9f1477d4a401457173b8d72af776c137
ToppCell390C-Fibroblasts-Fibroblast-K_(Pericytes)-|390C / Donor, Lineage, Cell class and subclass (all cells)

COL12A1 ADAMTS1 TNC FNDC4 MYOCD

2.89e-05198805dc63b56bb6291e527b172d603569376286262845
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZNF644 VPS13A CHD2 FRYL HERC1

2.96e-05199805f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T|COVID-19_Mild / Disease, condition lineage and cell class

GIMAP4 PPP2R5D AFAP1L2 ZNF831 LYST

2.96e-05199805f307d4887b28cf60a591439e278fd668409cb104
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E-|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL12A1 FOXP2 CENPF TNC LRRK1

3.03e-052008051a3d29a580d1b405a74869a1da3e818c581fc559
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E---L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL12A1 FOXP2 CENPF TNC LRRK1

3.03e-052008056f9ed8fe9cda91185c3a1a675353e11b8fec6ef1
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E--|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL12A1 FOXP2 CENPF TNC LRRK1

3.03e-0520080586705dfc05b3e1576543b93883c88fb55b742855
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL12A1 FOXP2 CENPF TNC LRRK1

3.03e-05200805db194b4f524fd008b3c5b4b6014b436190a1b87a
ToppCelldroplet-Fat-Mat-18m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXP2 CENPF LRRK1 CCDC77

6.72e-05121804e82c9e10b98c8d7ad828cf8ac19a2342014be2ba
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Krt80_Sla|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COL12A1 FOXP2 GLUL MYOCD

1.58e-04151804f50c5ae9dae507df750df25e151b58685fec70ce
ToppCellE16.5-samps-Mesenchymal-Myofibroblast-Migrating_MyoFibroblast|E16.5-samps / Age Group, Lineage, Cell class and subclass

TNC MYOCD ZNF831 POLK

1.75e-041558041882fa5fd25f77d6e3ac47b613f6fb3c67d8e50c
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GIMAP4 MCM10 USP1 ADAT1

1.79e-0415680433deda19f06172079ef1dd49fd54d66da1e7fb14
ToppCellfacs-Lung-Endomucin_-18m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD101 NCF4 ZNF831 LYST

1.84e-041578042b60de520edf167f5ca790b478557a778435b3d9
ToppCell367C-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

AFAP1L2 FOXP2 L1CAM MSH5

1.84e-04157804f511871e1a004c6e9af08ee325ab1bfc41807487
ToppCellAdult-Immune-mast_cell-D175|Adult / Lineage, Cell type, age group and donor

GIMAP4 AFAP1L2 LRRD1 ADAT1

1.93e-041598049f53fe2e0f25448d62a591c8e528e9a49b5400d5
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-Enterocyte_(Proximal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TECPR2 NCF4 LYST ALPI

1.93e-04159804709b57f992a29878cc899d760d144d36cb5cb280
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 FOXP2 MYOCD UNC80

1.97e-04160804c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 FOXP2 MYOCD UNC80

1.97e-0416080425c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell11.5-Distal-RBC|Distal / Age, Tissue, Lineage and Cell class

MPP1 STEAP3 ZC2HC1C CYB5R4

2.12e-04163804e9d814952d824539ff1dea119e4fca14a8c335a8
ToppCell11.5-Distal-RBC-RBC|Distal / Age, Tissue, Lineage and Cell class

MPP1 STEAP3 ZC2HC1C CYB5R4

2.12e-0416380431b60e065bac4ad380247964e7574f210106ebae
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFF1 AGBL5 CDC14B NOVA1

2.12e-04163804953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TTBK1 CENPF MCM10 USP1

2.22e-0416580488681101d7cf60b99b8ace5d8c0944323b937306
ToppCelldroplet-Skin-nan-18m-Epithelial-stem_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPF CKAP2 MCM10 CCDC77

2.22e-0416580496f0d8bc9b13e23f757e6bb98cd7dc061a8a9564
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L5_RORB_SNHG7|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL12A1 FOXP2 CENPF LRRK1

2.32e-041678045d89f5bcd0aaa772c1d09c2cc46fbfe0a90f9f12
ToppCell390C-Lymphocytic-ILC-ILC-2|390C / Donor, Lineage, Cell class and subclass (all cells)

CCP110 CD101 VPS33A CYB5R4

2.38e-041688042781dd6b369427a94c5059b44b4c8f023f5f2988
ToppCell367C-Lymphocytic-ILC-ILC-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

AFAP1L2 FOXP2 L1CAM MSH5

2.38e-0416880480233a13135fd159f5764336a1fe67fba237776b
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAI1 EFCAB6 RP1 NOVA1

2.43e-04169804fba841664939c771881ba97f14ef1df6635c04ff
ToppCelldroplet-Thymus-nan-21m-Myeloid-B_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXP2 NCF4 RYR1 NOVA1

2.54e-041718048bed33f61f7d12a1ac4fba33f730d839f5ee7bef
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

ADAMTS1 TNC L1CAM MYOCD

2.60e-04172804c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-SELL+_CD8_T|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 TRBV7-9 NAP1L4 ZNF831

2.60e-0417280410090b4b40f0f6f07a514e86811cadeecdf21670
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL12A1 CENPF CKAP2 CCDC77

2.60e-04172804c06ca5d075937747952ed915c9db39a9f62072f9
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL12A1 FOXP2 CENPF LRRK1

2.66e-04173804ee972d9cc68755926512fd3bbe1267098c67cd94
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFF1 FRYL MCM10 HERC1

2.72e-04174804f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellClub-club-15|World / Class top

RYBP CENPF MCM10 USP1

2.78e-04175804ca9d012f520f697c7450ec6958a015e20538a6a8
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL12A1 FOXP2 CENPF LRRK1

2.78e-0417580406af6629766e2054e6995e8cdb3907658fec49d3
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CENPF TNC MCM10 RYR1

2.78e-041758049142ed8ca2f1c0c518deb21988221406f62fe38c
ToppCelldroplet-Pancreas-PANCREAS-30m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP4 CD101 NCF4 ZNF831

2.78e-04175804ca2eabf03b70353e7eb15b6f622b2f9223a99e18
ToppCellwk_20-22-Hematologic-Meg-ery-Cycling_definitive_erythroblast|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MPP1 CENPF MEIKIN STEAP3

2.84e-0417680498814f0a67411b2f7b25dc489b2aadb77f45a853
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PPP2R5D CD101 INTS1 LYST

2.84e-0417680476fdf211bce101e83a27d822cb399487bd107027
ToppCellNasal_Brush-Epithelial-Basal_2|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

ADAMTS1 TNC FNDC4 NOVA1

2.84e-04176804fc5787946f5a10056d326d070620575ae4081836
ToppCellNasal_Brush-Epithelial-Basal_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

ADAMTS1 TNC FNDC4 NOVA1

2.84e-041768045daaba0853afe7d20d4635169ccd4f96e735b938
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPF CKAP2 MCM10 USP1

2.90e-041778048a74f5e72de605774111057bd87a7e7e4a6385cd
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL12A1 FOXP2 CENPF LRRK1

3.03e-04179804d3d3a9afaac28fa4f2c448c73d79bcbbbea088d7
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RAF1 AFAP1L2 VPS13A ZNF831

3.03e-041798046bbb32d7e582a96cb3cfc3eb911b05d518e7d5e9
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 AFAP1L2 L1CAM RP1

3.09e-04180804d9c9399df3e2d9f23dbbfffb6cbe8404bf01e2b7
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AFAP1L2 ADAMTS1 CENPF CKAP2

3.09e-0418080440d4838a0ccb10d5e49266bc8a0037d27b75ccc2
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 AFAP1L2 L1CAM RP1

3.09e-04180804dad458398683ff80a6e207bdc08e257d1bb757d6
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Red_blood_cells|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MPP1 MEIKIN STEAP3 MCM10

3.16e-04181804fe2f8b4bd8b09be8ba933529a16e1dca08740dab
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL12A1 ADAMTS1 TNC MYOCD

3.16e-04181804b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

VPS13A DGKH CHD2 HERC1

3.16e-04181804f2315414e714ac86211546a935660c4be6e85f1b
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Red_blood_cells-RBC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MPP1 MEIKIN STEAP3 MCM10

3.16e-04181804a16079b1c832456b974d9d06dd1a3eda63ac1bce
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL12A1 ADAMTS1 TNC NOVA1

3.22e-041828043dfa9187e9d2bab1d199079d29209c4648220ada
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 AFAP1L2 L1CAM RP1

3.22e-04182804812ff2a50a510b18d865e89465dba1754a08ef61
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD8-Trm/em_CD8|lymph-node_spleen / Manually curated celltypes from each tissue

GIMAP4 ZNF831 LYST ADAT1

3.22e-04182804f857b32de19240a8aca1685f7a78b4e53b04875c
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL12A1 ADAMTS1 TNC CDC14B

3.22e-04182804ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCellNS-moderate-d_16-33-Lymphoid-NK|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

COL12A1 TNC FNDC4 NOVA1

3.22e-04182804fb503f8ecd013f1f2161a5841572b57cfcddb6fa
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAI1 ARHGAP40 GLUL ACOT2

3.29e-041838047eaa6ef7c6cf848fd6489f97677f4406318da22f
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 EFCAB6 MYOCD UNC80

3.36e-041848042cbed6462fea2622871bb7e49b0df3d984239281
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL12A1 ADAMTS1 TNC MYOCD

3.36e-0418480454e5b63f55b8d6eccad53d389ea9c78f991e1414
ToppCellDividing_Macrophages-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

CENPF MEIKIN CKAP2 MCM10

3.36e-04184804f15ce786d25c6546804a6d1efcc2ad645f2ef54e
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 EFCAB6 MYOCD UNC80

3.36e-04184804ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 EFCAB6 MYOCD UNC80

3.36e-041848042b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL12A1 ADAMTS1 TNC MYOCD

3.36e-041848047b5678718719020b52e7c2a7bd9797987defd7ff
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCP110 CENPF NCF4 CKAP2

3.36e-041848048f40093de5bb978f046d66e8f05f333686a009a4
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXP2 ADAMTS1 TNC MYOCD

3.43e-041858046712512100ccef456d2e2bd201d0987986c92ac9
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Hematopoietic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MPP1 AFAP1L2 TECPR2 CDC14B

3.43e-04185804c985a4b184d382a79aaff07f81c0efede2c2d493
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic-Megakaryocyte|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MPP1 AFAP1L2 TECPR2 CDC14B

3.43e-04185804d0d0e000ebe1fc35a987930ceaf7e3369e0c694c
ToppCellCOVID-19-Heart-Fib_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

COL12A1 FOXP2 TNC NOVA1

3.43e-041858048f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MPP1 AFAP1L2 TECPR2 CDC14B

3.43e-041858040ca99fcbd30c454bcdc2aa5265a0e4dba25666ea
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MPP1 AFAP1L2 TECPR2 CDC14B

3.43e-041858040f722ffcc3e78d5c6b1b79d31d00929801a993f1
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTBK1 AFAP1L2 L1CAM UNC80

3.50e-04186804d8d559daff4aeef334d403fde4e3ee2e4a6086d0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CENPF TNC CKAP2 MCM10

3.57e-04187804e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CENPF TNC CKAP2 MCM10

3.57e-04187804cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

COL12A1 ADAMTS1 TNC MYOCD

3.57e-04187804464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EFCAB6 FOXP2 RP1 NOVA1

3.57e-04187804c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CENPF CKAP2 MCM10 RYR1

3.57e-0418780473931a5ea73799095daff100b5f18853c57c74dc
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MPP1 GLUL AFF1 RYR1

3.64e-041888043be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCelldroplet-Spleen-nan-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPF STEAP3 CKAP2 MCM10

3.64e-041888041a3f95b4fd7611c634666761ddf21f1e58e56af8
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXP2 ADAMTS1 TNC MYOCD

3.64e-04188804293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell5'-Adult-SmallIntestine-Mesenchymal-myocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL12A1 ADAMTS1 TNC MYOCD

3.72e-04189804ab7ece0a517499b70b7754720d3e434765363af6
Drugthioridazine hydrochloride; Down 200; 10uM; PC3; HT_HG-U133A

MPP1 ATR CENPF TNC UBE3B PACSIN3 MCM10

4.11e-061937771230_DN
Diseasecorneal topography

NHSL1 HDAC11 LRRK1 USP1

1.84e-04109764EFO_0004345
Diseasegrowth rate measurement

GLUL CCDC77

3.55e-0411762EFO_0010572
DiseaseSpastic Paraplegia, Hereditary

TECPR2 L1CAM

5.84e-0414762C0037773
DiseaseChronic myeloproliferative disorder

ATR CENPF

1.09e-0319762C1292778
DiseaseSeckel syndrome

ATR CENPF

1.46e-0322762C0265202
Diseaseintestinal permeability measurement

PPP2R5D ADAMTS1

2.04e-0326762EFO_0011031
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

AFF1 ACOT2 CYB5R4

2.55e-03105763DOID:9352 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
TLNVGVNKKRGLRTP

AGBL5

606

Q8NDL9
NVPRKGILKSGTRSL

CXorf58

6

Q96LI9
PGVKKIRSSTQQDPR

CDC14B

26

O60729
VQRKVLRPLRTQTGG

HDAC11

106

Q96DB2
KNRPLSVVVTGKGTV

AFAP1L2

791

Q8N4X5
VVSKRGVAVSGPTKR

CCDC77

16

Q9BR77
GGPQIVKKERRQSSS

PPP2R5D

76

Q14738
PVGVNRNRIKVTKDG

ACOT2

336

P49753
KQPHKQSISIGRGTR

DNAI1

11

Q9UI46
KVKGPTFRISGVQVN

CHD1

1196

O14646
VGRPIIRSTTKVGNI

ACTR2

36

P61160
PQGTTKKTIGSLQAR

ADAT1

416

Q9BUB4
GISRTSANVTIRKGP

CKAP2

271

Q8WWK9
VSGTQEKNKIRPRGQ

RAF1

321

P04049
QPTGTGSIRKKRFVS

ADAMTS1

241

Q9UHI8
HKGRGTVRTITKQVP

NAP1L4

271

Q99733
NISQIKGRKLTRLPG

LRRD1

631

A4D1F6
LFSRRKGKGQAQVPS

INTS1

1641

Q8N201
NIKGSRSVAKNGVIR

LRRK1

936

Q38SD2
GTVTRITPKGKITVQ

HERC2

2231

O95714
GPQITVKRISTRGRK

HERC1

4471

Q15751
ASPKQVGSIQRSIRK

NHSL1

1401

Q5SYE7
SVASGPVVGVRKKVR

KAT14

391

Q9H8E8
QKRRSQKITGSPTLV

FOXP2

581

O15409
AGRNGKPKVIAVTRS

FRYL

2316

O94915
RPRTRKVKSVSPQGN

NCF4

151

Q15080
TQGPRSTIEKKGSRV

L1CAM

521

P32004
IIRTSPGTRQVKNKG

MEIKIN

336

A0A087WXM9
QTISRNKPSGITRGQ

MCM10

216

Q7L590
EGPQKLIRKVSTSGQ

DGKH

46

Q86XP1
RGINGVSPKVRKVLQ

RPL7

96

P18124
QQLRIRGLPVSGTKT

MYOCD

381

Q8IZQ8
GSSGQRKRKVQLLPS

POM121C

476

A8CG34
TPGSSGQRKRKVQLL

POM121B

81

A6NF01
PTVTATRILKGQKNG

ALPI

66

P09923
STPGSSGQRKRKVQL

POM121

496

Q96HA1
GVIKTRNRVTGLPLS

ATR

2601

Q13535
KLSIGQREVTVQKGP

CD101

16

Q93033
GGSRSQKVKVAQRSP

CENPF

3041

P49454
TGRGKTKPLNTVRNL

COL12A1

1836

Q99715
QGLQVSSKGPLTKRN

EFCAB6

366

Q5THR3
RGPTIKISGVQVNVK

CHD2

1206

O14647
GRPVGTRQKKSPSIN

FNDC4

216

Q9H6D8
QSPTRVLGNKKGIFT

GUSB

596

P08236
RLLSRQGTPKTSVKG

CCP110

961

O43303
QQPQGKRRIHGKISI

LYST

1601

Q99698
PQKGRRKRTAITGSQ

DUX1

91

O43812
GSPAQVKGQEVRKVR

MPP1

56

Q00013
RLGKVSQARTQVKGV

RYR1

3111

P21817
TQRTISRKEKGGRSP

PACSIN3

306

Q9UKS6
QISKKGEFVPGTRNR

NOVA1

456

P51513
TPGLRRVRQKKSVIG

RP1

451

P56715
RVKVITGPNSSGKSI

MSH5

586

O43196
ASIRIPRTVGQEKKG

GLUL

321

P15104
STRRTGSQKEIPKGI

TRMT11

316

Q7Z4G4
PRNSQLRIVLVGKTG

GIMAP4

26

Q9NUV9
VRKGTSTRKPRINSQ

RYBP

46

Q8N488
SPGKTVTIVVRGSNK

CCT4

381

P50991
QRVASGGRSKVPLKQ

CYB5R4

16

Q7L1T6
SIPKQRRVEGKGSRS

AFF1

911

P51825
LNTVSKIRGQVKNPG

SH3GL1

71

Q99961
KGTSKRLQGSVPQVL

ZNF197

281

O14709
PRGKLQAQRATTKGR

TTBK1

1296

Q5TCY1
GSKKVTIRSPVQIRN

VPS13A

1986

Q96RL7
VNITKKGLSRGRSPI

UNC80

1246

Q8N2C7
RVPGSQARVKGLEQK

ARHGAP40

311

Q5TG30
SRVLNLGPITRKGVQ

UMOD

596

P07911
LGPITRKGVQATVSR

UMOD

601

P07911
GFKVVVGSRNPKRTA

STEAP3

51

Q658P3
KETRGVQKRRGGSTV

SLC39A7

281

Q92504
SSGVQKAVTRTKRPG

POLK

831

Q9UBT6
VKNNTRGPGLKRVTT

TNC

786

P24821
KSVRQIGTQPRKSTG

TECPR2

201

O15040
KTRKSPQVTRGSPQK

VRK3

111

Q8IV63
IKTRGQQVTLRCSPK

TRBV5-6

31

A0A599
IILPRSRVKGNKSNT

ZC2HC1C

266

Q53FD0
QHFKRTGTGTPVKRV

ZNF644

1011

Q9H582
KSASVRNILRPVGGK

UBE3B

436

Q7Z3V4
TGVSQNPRHKITKRG

TRBV7-9

21

P04435
TGLQKKRQPGENRVT

VPS33A

531

Q96AX1
NVRPRKTGLSKQGSI

ZNF831

426

Q5JPB2
IRVGGNTQPSKVLNK

USP1

646

O94782