Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	SETD1A KMT2C WDR5	6.97e-05	20	81	3	GO:0042800
GeneOntologyMolecularFunction	collagen V binding	GPC1 HSPG2	1.61e-04	5	81	2	GO:0070052
GeneOntologyMolecularFunction	clathrin light chain binding	HIP1 HIP1R	3.37e-04	7	81	2	GO:0032051
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	SETD1A KMT2C	4.48e-04	8	81	2	GO:0140945
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	SETD1A KMT2C	7.16e-04	10	81	2	GO:0140999
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	SETD1A KMT2C WDR5	7.55e-04	44	81	3	GO:0140938
GeneOntologyMolecularFunction	G-rich strand telomeric DNA binding	CTC1 RPA1	8.73e-04	11	81	2	GO:0098505
GeneOntologyCellularComponent	Set1C/COMPASS complex	SETD1A WDR5B WDR5 HCFC2	3.32e-07	16	79	4	GO:0048188
GeneOntologyCellularComponent	histone methyltransferase complex	SETD1A KMT2C WDR5B WDR5 HCFC2	9.52e-06	75	79	5	GO:0035097
GeneOntologyCellularComponent	methyltransferase complex	SETD1A KMT2C WDR5B WDR5 HCFC2	5.58e-05	108	79	5	GO:0034708
GeneOntologyCellularComponent	extracellular matrix	GPC1 HSPG2 SEMA7A ITLN1 HSD17B12 HPSE2 LOXL3 ANXA9 ANGPTL7	8.12e-04	656	79	9	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	GPC1 HSPG2 SEMA7A ITLN1 HSD17B12 HPSE2 LOXL3 ANXA9 ANGPTL7	8.30e-04	658	79	9	GO:0030312
GeneOntologyCellularComponent	MLL3/4 complex	KMT2C WDR5	9.08e-04	12	79	2	GO:0044666
Domain	Transcription_factor_COE	EBF2 EBF3 EBF4	2.69e-07	4	77	3	IPR003523
Domain	COE_HLH	EBF2 EBF3 EBF4	2.69e-07	4	77	3	IPR032201
Domain	COE_DBD	EBF2 EBF3 EBF4	2.69e-07	4	77	3	IPR032200
Domain	Transcription_factor_COE_CS	EBF2 EBF3 EBF4	2.69e-07	4	77	3	IPR018350
Domain	COE1_HLH	EBF2 EBF3 EBF4	2.69e-07	4	77	3	PF16423
Domain	COE1_DBD	EBF2 EBF3 EBF4	2.69e-07	4	77	3	PF16422
Domain	COE	EBF2 EBF3 EBF4	2.69e-07	4	77	3	PS01345
Domain	-	WDR91 AAAS WDR5B PLAA SEMA7A FSTL4 WDR5 TEP1 SEMA4C	9.09e-06	333	77	9	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR91 AAAS WDR5B PLAA SEMA7A FSTL4 WDR5 TEP1 SEMA4C	9.53e-06	335	77	9	IPR015943
Domain	M_domain	TNRC6A TNRC6C	1.68e-05	2	77	2	PF12938
Domain	GW182_M_dom	TNRC6A TNRC6C	1.68e-05	2	77	2	IPR026805
Domain	HIP1_clath-bd	HIP1 HIP1R	1.68e-05	2	77	2	IPR032422
Domain	Sla2_fam	HIP1 HIP1R	1.68e-05	2	77	2	IPR030224
Domain	HIP1_clath_bdg	HIP1 HIP1R	1.68e-05	2	77	2	PF16515
Domain	Ago_hook	TNRC6A TNRC6C	5.02e-05	3	77	2	PF10427
Domain	TNRC6_PABC-bd	TNRC6A TNRC6C	5.02e-05	3	77	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6A TNRC6C	5.02e-05	3	77	2	IPR019486
Domain	TNRC6-PABC_bdg	TNRC6A TNRC6C	5.02e-05	3	77	2	PF16608
Domain	I_LWEQ	HIP1 HIP1R	1.00e-04	4	77	2	PF01608
Domain	ILWEQ_dom	HIP1 HIP1R	1.00e-04	4	77	2	IPR002558
Domain	I_LWEQ	HIP1 HIP1R	1.00e-04	4	77	2	PS50945
Domain	ILWEQ	HIP1 HIP1R	1.00e-04	4	77	2	SM00307
Domain	ANTH_dom	HIP1 HIP1R	1.00e-04	4	77	2	IPR011417
Domain	ILWEQ	HIP1 HIP1R	1.00e-04	4	77	2	PD011820
Domain	ANTH	HIP1 HIP1R	1.00e-04	4	77	2	PF07651
Domain	-	HIP1 HIP1R	1.00e-04	4	77	2	1.20.1410.10
Domain	IPT	EBF2 EBF3 EBF4	1.84e-04	27	77	3	SM00429
Domain	TIG	EBF2 EBF3 EBF4	2.79e-04	31	77	3	PF01833
Domain	IPT	EBF2 EBF3 EBF4	3.07e-04	32	77	3	IPR002909
Domain	-	EBF2 CNTN4 HSPG2 SEMA7A EBF3 INSRR FSTL4 HCFC2 EBF4 SEMA4C	3.81e-04	663	77	10	2.60.40.10
Domain	ENTH	HIP1 HIP1R	5.93e-04	9	77	2	PS50942
Domain	ENTH	HIP1 HIP1R	5.93e-04	9	77	2	SM00273
Domain	Ig-like_fold	EBF2 CNTN4 HSPG2 SEMA7A EBF3 INSRR FSTL4 HCFC2 EBF4 SEMA4C	6.23e-04	706	77	10	IPR013783
Domain	WD40	WDR91 AAAS WDR5B PLAA WDR5 TEP1	6.99e-04	259	77	6	PF00400
Domain	Gprotein_B	WDR5B WDR5	7.39e-04	10	77	2	IPR001632
Domain	ENTH	HIP1 HIP1R	7.39e-04	10	77	2	IPR013809
Domain	WD40	WDR91 AAAS WDR5B PLAA WDR5 TEP1	8.35e-04	268	77	6	SM00320
Domain	WD40_repeat	WDR91 AAAS WDR5B PLAA WDR5 TEP1	9.01e-04	272	77	6	IPR001680
Domain	WD_REPEATS_1	WDR91 AAAS WDR5B PLAA WDR5 TEP1	1.01e-03	278	77	6	PS00678
Domain	WD_REPEATS_2	WDR91 AAAS WDR5B PLAA WDR5 TEP1	1.03e-03	279	77	6	PS50082
Domain	WD_REPEATS_REGION	WDR91 AAAS WDR5B PLAA WDR5 TEP1	1.03e-03	279	77	6	PS50294
Domain	WD40_repeat_dom	WDR91 AAAS WDR5B PLAA WDR5 TEP1	1.42e-03	297	77	6	IPR017986
Domain	Post-SET_dom	SETD1A KMT2C	1.94e-03	16	77	2	IPR003616
Domain	PostSET	SETD1A KMT2C	1.94e-03	16	77	2	SM00508
Domain	POST_SET	SETD1A KMT2C	1.94e-03	16	77	2	PS50868
Domain	LH2	LOXHD1 PKD1	2.46e-03	18	77	2	SM00308
Domain	Semaphorin	SEMA7A SEMA4C	3.04e-03	20	77	2	IPR027231
Domain	PLAT	LOXHD1 PKD1	3.35e-03	21	77	2	PS50095
Domain	-	LOXHD1 PKD1	3.35e-03	21	77	2	2.60.60.20
Domain	PLAT	LOXHD1 PKD1	3.35e-03	21	77	2	PF01477
Domain	PLAT/LH2_dom	LOXHD1 PKD1	3.35e-03	21	77	2	IPR001024
Domain	Quino_amine_DH_bsu	FSTL4 TEP1	3.67e-03	22	77	2	IPR011044
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	SETD1A KMT2C WDR5 HCFC2	2.75e-05	42	59	4	M48018
Pathway	REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION	SETD1A KMT2C TNRC6A WDR5 TNRC6C	4.94e-05	96	59	5	M27792
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_ATTACHMENT_AND_ENTRY	GPC1 HSPG2 TLR4	1.16e-04	23	59	3	M48234
Pathway	REACTOME_HS_GAG_DEGRADATION	GPC1 HSPG2 HPSE2	1.32e-04	24	59	3	M636
Pubmed	Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate oligo-based direct selection.	EBF2 EBF3 EBF4	5.04e-08	4	82	3	12139918
Pubmed	Expression patterns of the coe/ebf transcription factor genes during chicken and mouse limb development.	EBF2 EBF3 EBF4	1.26e-07	5	82	3	15261831
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	SETD1A KMT2C WDR5 HCFC2	2.03e-07	22	82	4	26886794
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SETD1A HSPG2 KMT2C HIP1 SEMA7A CANT1 CTC1 DOCK9 PKD1 HIP1R APEH SLC10A3 TNRC6C TEP1	2.89e-07	1105	82	14	35748872
Pubmed	Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.	EBF2 EBF3 EBF4	4.39e-07	7	82	3	24786561
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	SETD1A KMT2C WDR5	7.01e-07	8	82	3	22266653
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	SETD1A KMT2C WDR5	1.05e-06	9	82	3	22665483
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	SETD1A KMT2C WDR5	2.74e-06	12	82	3	27563068
Pubmed	An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development.	EBF2 EBF3 EBF4	2.74e-06	12	82	3	30658714
Pubmed	Transient and lineage-restricted requirement of Ebf3 for sternum ossification.	EBF2 EBF3 EBF4	2.74e-06	12	82	3	32398354
Pubmed	Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1.	HIP1 HIP1R	5.49e-06	2	82	2	15121852
Pubmed	Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1.	HIP1 HIP1R	5.49e-06	2	82	2	17452370
Pubmed	Unified nomenclature for the semaphorins/collapsins. Semaphorin Nomenclature Committee.	SEMA7A SEMA4C	5.49e-06	2	82	2	10367884
Pubmed	The effects of hydrated C(60) fullerene on gene expression profile of TRPM2 and TRPM7 in hyperhomocysteinemic mice.	TRPM7 TRPM2	5.49e-06	2	82	2	24646197
Pubmed	HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains.	HIP1 HIP1R	5.49e-06	2	82	2	14732715
Pubmed	The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?	HIP1 HIP1R	5.49e-06	2	82	2	20074057
Pubmed	Is there any difference between endometrial hyperplasia and endometrial carcinoma in terms of expression of TRPM2 and TRPM7 ion channels?	TRPM7 TRPM2	5.49e-06	2	82	2	30997980
Pubmed	Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.	HIP1 HIP1R	5.49e-06	2	82	2	17928447
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	SETD1A KMT2C WDR5 HCFC2	6.09e-06	50	82	4	37974198
Pubmed	SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.	SETD1A KMT2C WDR5	6.92e-06	16	82	3	23870121
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	SETD1A KMT2C WDR5	1.00e-05	18	82	3	17500065
Pubmed	A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.	SETD1A KMT2C WDR5 HCFC2	1.35e-05	61	82	4	20305087
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	SETD1A KMT2C WDR5	1.40e-05	20	82	3	29785026
Pubmed	Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy.	GPC1 HSPG2	1.64e-05	3	82	2	11968010
Pubmed	Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation.	RB1 PKD1	1.64e-05	3	82	2	21900881
Pubmed	HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.	HIP1 HIP1R	1.64e-05	3	82	2	11063258
Pubmed	The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development.	EBF2 EBF3	1.64e-05	3	82	2	9151732
Pubmed	[Allelic variants of immune response genes in children with infectious complications during the treatment of acute leukemia].	TLR4 PTPN22	1.64e-05	3	82	2	28537236
Pubmed	Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling.	TLR4 HPSE2	1.64e-05	3	82	2	31537875
Pubmed	Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.	TNRC6A TNRC6C	1.64e-05	3	82	2	31670606
Pubmed	Deficiency of the Endocytic Protein Hip1 Leads to Decreased Gdpd3 Expression, Low Phosphocholine, and Kypholordosis.	HIP1 HIP1R	1.64e-05	3	82	2	30224518
Pubmed	Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.	TNRC6A TNRC6C	1.64e-05	3	82	2	34108231
Pubmed	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.	TNRC6A TNRC6C	1.64e-05	3	82	2	16880270
Pubmed	Huntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain.	HIP1 HIP1R	1.64e-05	3	82	2	15533941
Pubmed	Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors.	EBF2 EBF3 EBF4	2.47e-05	24	82	3	20826655
Pubmed	Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.	HIP1 HIP1R	3.28e-05	4	82	2	18790740
Pubmed	Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development.	EBF2 EBF3	3.28e-05	4	82	2	9151733
Pubmed	The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets.	TNRC6A TNRC6C	3.28e-05	4	82	2	23172285
Pubmed	Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.	TRPM7 TLR4	3.28e-05	4	82	2	29343440
Pubmed	Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.	TNRC6A TNRC6C	3.28e-05	4	82	2	21063388
Pubmed	Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein.	TNRC6A TNRC6C	3.28e-05	4	82	2	20181956
Pubmed	TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections.	TLR4 UNC93B1	3.28e-05	4	82	2	31433296
Pubmed	Renal tubular cell spliced X-box binding protein 1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation.	TLR4 PKD1	3.28e-05	4	82	2	31601454
Pubmed	Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-κB pathway, NAD(P)H oxidase activation, and transient receptor potential melastatin 7 calcium channel activity.	TRPM7 TLR4	3.28e-05	4	82	2	25130439
Pubmed	Intrasteric inhibition mediates the interaction of the I/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin.	HIP1 HIP1R	3.28e-05	4	82	2	15581353
Pubmed	Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.	ITLN1 MUC19 PTPN22	3.97e-05	28	82	3	18587394
Pubmed	EBF2 determines and maintains brown adipocyte identity.	EBF2 EBF3 EBF4	4.42e-05	29	82	3	23499423
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	KMT2C WAPL PLAA CANT1 CTC1 DOCK9 TLR4 ZNF507 TANGO2 ANKRD50 RPA1	4.75e-05	1084	82	11	11544199
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	SETD1A KMT2C WDR5	5.41e-05	31	82	3	20516061
Pubmed	Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.	SUGT1 RPA1 NEURL4	5.41e-05	31	82	3	22261722
Pubmed	Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires a paired homeodomain transcription factor, Drg11.	EBF2 EBF3	5.47e-05	5	82	2	12917357
Pubmed	Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation.	KMT2C PTPN22	5.47e-05	5	82	2	27653681
Pubmed	Macrophage Mitochondrial Biogenesis and Metabolic Reprogramming Induced by Leishmania donovani Require Lipophosphoglycan and Type I Interferon Signaling.	TLR4 UNC93B1	5.47e-05	5	82	2	36222510
Pubmed	Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte.	TRPM7 TRPM2	5.47e-05	5	82	2	16857711
Pubmed	ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals.	HIP1 HIP1R	5.47e-05	5	82	2	34821552
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPM7 TRPM2 PKD1	6.55e-05	33	82	3	19834762
Pubmed	Sequence specific detection of bacterial 23S ribosomal RNA by TLR13.	TLR4 UNC93B1	8.19e-05	6	82	2	23110254
Pubmed	Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits.	HIP1 HIP1R	8.19e-05	6	82	2	25122462
Pubmed	GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.	SETD1A WDR5	8.19e-05	6	82	2	34933446
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	KMT2C WDR5	8.19e-05	6	82	2	17021013
Pubmed	Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system.	EBF2 EBF3	8.19e-05	6	82	2	9389446
Pubmed	LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1.	TLR4 UNC93B1	8.19e-05	6	82	2	26466955
Pubmed	B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota.	TLR4 UNC93B1	8.19e-05	6	82	2	31433298
Pubmed	Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo.	HIP1 HIP1R	8.19e-05	6	82	2	15533940
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	SUGT1 TRPM7 TNRC6A APEH HCFC2 ANKRD50 ARMCX3 TMEM263 SEMA4C	9.06e-05	777	82	9	35844135
Pubmed	Endotoxin Tolerance Inhibits Lyn and c-Src Phosphorylation and Association with Toll-Like Receptor 4 but Increases Expression and Activity of Protein Phosphatases.	TLR4 PTPN22	1.14e-04	7	82	2	26457672
Pubmed	Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex.	KMT2C WDR5	1.14e-04	7	82	2	26324722
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	TNRC6A TNRC6C	1.14e-04	7	82	2	19383768
Pubmed	Age-dependent enterocyte invasion and microcolony formation by Salmonella.	TLR4 UNC93B1	1.14e-04	7	82	2	25210785
Pubmed	CXXC finger protein 1 contains redundant functional domains that support embryonic stem cell cytosine methylation, histone methylation, and differentiation.	SETD1A WDR5	1.14e-04	7	82	2	19433449
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2C WDR5	1.14e-04	7	82	2	30604749
Pubmed	RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway.	CTC1 RPA1	1.14e-04	7	82	2	19854130
Pubmed	A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.	KMT2C WDR5	1.14e-04	7	82	2	19433796
Pubmed	HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.	HIP1 HIP1R	1.14e-04	7	82	2	11889126
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	TNRC6A TNRC6C	1.14e-04	7	82	2	19470757
Pubmed	The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation.	SETD1A WDR5	1.14e-04	7	82	2	23453808
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	SETD1A KMT2C WDR5	1.46e-04	43	82	3	33472061
Pubmed	CFP1 interacts with DNMT1 independently of association with the Setd1 Histone H3K4 methyltransferase complexes.	SETD1A WDR5	1.52e-04	8	82	2	18680430
Pubmed	CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.	SETD1A WDR5	1.52e-04	8	82	2	16253997
Pubmed	Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.	WDR5 HCFC2	1.52e-04	8	82	2	31804488
Pubmed	Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection.	EBF2 EBF3	1.52e-04	8	82	2	14993187
Pubmed	TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes.	TLR4 UNC93B1	1.52e-04	8	82	2	22745710
Pubmed	A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.	TNRC6A TNRC6C	1.52e-04	8	82	2	24768540
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	SETD1A KMT2C	1.52e-04	8	82	2	23130995
Pubmed	Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.	SETD1A WDR5	1.52e-04	8	82	2	17355966
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	TRPM7 TRPM2 PKD1	1.56e-04	44	82	3	19322198
Pubmed	N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.	WDR91 KMT2C HIP1R TANGO2 ANKRD50	1.67e-04	217	82	5	34048709
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	GPD1L CNTN4 VPS18 RHOBTB1 DYNC2H1 NEURL4 SEMA4C	1.68e-04	493	82	7	15368895
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	SETD1A KMT2C WDR5 HCFC2	1.85e-04	119	82	4	23508102
Pubmed	FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.	AAAS TNRC6A HSD17B12 RPA1 NEURL4	1.89e-04	223	82	5	34226595
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	WDR91 VPS18 AAAS TRPM7 ANKRD50 ARMCX3 SEMA4C	1.92e-04	504	82	7	34432599
Pubmed	IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema.	TLR4 UNC93B1	1.96e-04	9	82	2	20007584
Pubmed	Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.	WDR5 HCFC2	1.96e-04	9	82	2	15199122
Pubmed	Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin.	GPC1 HSPG2	1.96e-04	9	82	2	15381701
Pubmed	A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns.	TLR4 UNC93B1	1.96e-04	9	82	2	30170812
Pubmed	MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice.	TLR4 UNC93B1	1.96e-04	9	82	2	22466646
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	GPC1 HIP1 PLAA DOCK9 HIP1R	2.18e-04	230	82	5	35449600
Pubmed	Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.	SETD1A WDR5	2.44e-04	10	82	2	17998332
Pubmed	Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.	SETD1A WDR5	2.44e-04	10	82	2	18838538
Pubmed	miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.	TNRC6A TNRC6C	2.44e-04	10	82	2	21984185
Interaction	SETD1A interactions	SETD1A KMT2C INSRR KYAT3 WDR5 HCFC2 RPA1	4.67e-06	170	79	7	int:SETD1A
Interaction	SETD1B interactions	SETD1A KMT2C WDR5 HCFC2 RPA1	1.13e-05	75	79	5	int:SETD1B
Interaction	KMT2C interactions	SETD1A KMT2C TNRC6A WDR5 HCFC2 RPA1	1.44e-05	134	79	6	int:KMT2C
Interaction	CNOT7 interactions	TNRC6A APEH TNRC6C HCFC2 PARP14 RPA1	1.85e-05	140	79	6	int:CNOT7
Interaction	NCOA6 interactions	SETD1A KMT2C RB1 TNRC6A WDR5 HCFC2	2.26e-05	145	79	6	int:NCOA6
GeneFamily	WD repeat domain containing	WDR91 AAAS WDR5B PLAA WDR5 TEP1	7.25e-05	262	49	6	362
GeneFamily	Immunoglobulin like domain containing	CNTN4 HSPG2 SEMA7A FSTL4 SEMA4C	1.71e-04	193	49	5	594
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA7A SEMA4C	1.33e-03	20	49	2	736
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC6A TNRC6C	2.07e-03	25	49	2	775
GeneFamily	Transient receptor potential cation channels	TRPM7 TRPM2	2.60e-03	28	49	2	249
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1A KMT2C	3.82e-03	34	49	2	487
Coexpression	NABA_ECM_AFFILIATED	GPC1 SEMA7A ITLN1 MUC19 ANXA9 SEMA4C	9.07e-06	158	80	6	MM17063
Coexpression	NABA_ECM_AFFILIATED	GPC1 SEMA7A ITLN1 MUC19 ANXA9 SEMA4C	1.38e-05	170	80	6	M5880
Coexpression	NABA_MATRISOME_ASSOCIATED	GPC1 SEMA7A ITLN1 MUC19 HPSE2 HABP2 LOXL3 HCFC2 ANXA9 ANGPTL7 SEMA4C	1.47e-05	738	80	11	MM17058
Coexpression	NABA_MATRISOME_ASSOCIATED	GPC1 SEMA7A ITLN1 MUC19 HPSE2 HABP2 LOXL3 HCFC2 ANXA9 ANGPTL7 SEMA4C	1.72e-05	751	80	11	M5885
Coexpression	GSE32901_NAIVE_VS_TH17_NEG_CD4_TCELL_DN	CNTN4 SEMA7A XIRP2 KYAT3 UNC93B1	4.11e-05	125	80	5	M8930
Coexpression	NABA_MATRISOME	GPC1 HSPG2 SEMA7A ITLN1 MUC19 HPSE2 HABP2 LOXL3 HCFC2 ANXA9 ANGPTL7 SEMA4C	5.30e-05	1008	80	12	MM17056
Coexpression	NABA_MATRISOME	GPC1 HSPG2 SEMA7A ITLN1 MUC19 HPSE2 HABP2 LOXL3 HCFC2 ANXA9 ANGPTL7 SEMA4C	6.28e-05	1026	80	12	M5889
Disease	congenital heart disease (implicated_via_orthology)	KMT2C WDR5B WDR5 HCFC2	3.60e-05	69	79	4	DOID:1682 (implicated_via_orthology)
Disease	Disproportionate short stature	HSPG2 DYM CANT1 DYNC2H1	5.55e-05	77	79	4	C0878659
Disease	glypican-1 measurement	GPC1 HABP2	1.47e-04	7	79	2	EFO_0801649
Disease	Moyamoya disease	DOCK9 FSTL4 TSC22D2	1.70e-04	40	79	3	MONDO_0016820
Disease	diabetic neuropathy (implicated_via_orthology)	TLR4 INSRR	6.31e-04	14	79	2	DOID:9743 (implicated_via_orthology)
Disease	temporal arteritis (is_implicated_in)	TLR4 PTPN22	8.29e-04	16	79	2	DOID:13375 (is_implicated_in)
Disease	anorectal malformation	TRPM2 ZNF507	1.18e-03	19	79	2	MONDO_0019938
Disease	osteochondrodysplasia (is_implicated_in)	HSPG2 DYM	1.18e-03	19	79	2	DOID:2256 (is_implicated_in)
Disease	uric acid measurement	CNTN4 TRPM7 DYNC2H1 INSRR ANKRD50 RPA1 ARMCX3	1.25e-03	610	79	7	EFO_0004761
Disease	cardiovascular disease	EBF2 WAPL HSD17B12 KYAT3 TSC22D2 TANGO2	1.43e-03	457	79	6	EFO_0000319
Disease	vitiligo (is_implicated_in)	TLR4 PTPN22	1.44e-03	21	79	2	DOID:12306 (is_implicated_in)
Disease	waist-hip ratio	EBF2 DYM DYNC2H1 PKD1 TNRC6A HIP1R NAV3 HSD17B12 WDR5 TSC22D2	1.58e-03	1226	79	10	EFO_0004343
Disease	Parkinson disease	SETD1A CTC1 TRPM2 HIP1R MUC19	1.72e-03	321	79	5	MONDO_0005180
Disease	Bipolar Disorder	CNTN4 PSEN2 DOCK9 TRPM2 TLR4 HIP1R	1.78e-03	477	79	6	C0005586
Disease	body fat percentage	DYM TRPM2 TNRC6A HSD17B12 TSC22D2 RPA1	1.99e-03	488	79	6	EFO_0007800
Disease	Sezary Syndrome	KMT2C RB1	2.38e-03	27	79	2	C0036920
Disease	neuroblastoma, cutaneous melanoma	HSD17B12 ANXA9	2.56e-03	28	79	2	EFO_0000389, EFO_0000621
Disease	glucose metabolism disease (implicated_via_orthology)	TLR4 INSRR	2.56e-03	28	79	2	DOID:4194 (implicated_via_orthology)
Disease	glomerular filtration rate, response to platinum based chemotherapy	CNTN4 HSD17B12	2.56e-03	28	79	2	EFO_0004647, EFO_0005208

Protein segments in the cluster

Peptide	Gene	Start	Entry
KGALLSVGWSTGRIA	AAAS	466	Q9NRG9
LGSWLGGTQRKEGTG	CTC1	766	Q2NKJ3
GLGGLIVVSKTGDWV	ASRGL1	261	Q7L266
AVLGSVRTGGAGSKW	AFDN-DT	116	Q9Y6Z5
LGSVRTGGAGSKWAV	AFDN-DT	166	Q9Y6Z5
SGWVKRGPTGVIATT	FDXR	396	P22570
DRVGSVKVSSGTWVG	CRYBB1	181	P53674
VSGGGGSKSELVITW	CNTN4	706	Q8IWV2
SEGWTTGGAMVIIIG	EBF2	261	Q9HAK2
ASGVSGKGAAWGVLL	ANKRD50	61	Q9ULJ7
KVGWVTAGLVIGAGA	ARMCX3	6	Q9UH62
LTWEKVSSVDGVLGG	RB1	76	P06400
GVPSATITWRKEGGS	HSPG2	1981	P98160
VKVKIGTSLEWGGTS	PTPN22	646	Q9Y2R2
TSGGGWTIIQRRKSG	ANGPTL7	166	O43827
DMTSGGGGWTLVASV	ITLN1	71	Q8WWA0
GEGRVEVLKASTWGT	LOXL3	316	P58215
GSAIWSIKVGRGSGF	KMT2C	876	Q8NEZ4
GSGVVGWSIPVTKGV	HCFC2	171	Q9Y5Z7
QSIVVSGESGAGKTW	MYO19	126	Q96H55
TDKFWGTSGVESVIG	GPC1	301	P35052
VGSGNWGSAVAKIIG	GPD1L	11	Q8N335
GKGLEWVSSISGGST	IGHV3-38	61	A0A0C4DH36
GKGLEWVSSISGGST	IGHV3-38-3	61	P0DTE1
MTVWTGDVVGGGTDS	LOXHD1	1556	Q8IVV2
VGGLGKEWTTTTGDV	CANT1	226	Q8WVQ1
STSKGSGAGSGPWIK	MCF2L2	971	Q86YR7
VGLVKGALGWSVSRG	PDHX	26	O00330
TPGGATSGGKITSGW	MUC19	2006	Q7Z5P9
WITGPLAGVTGTTGI	MUC19	4461	Q7Z5P9
GTTGLSAWVTGIAGL	MUC19	4621	Q7Z5P9
SAWVTGIAGLSAGVT	MUC19	4626	Q7Z5P9
GTSGTGFKTGTSWVA	MUC19	7386	Q7Z5P9
GFKTGTSWVAPGTTV	MUC19	7391	Q7Z5P9
TIKNVSAITWGGGGG	SLC10A3	116	P09131
SIGVSGKTKWDVLDG	NAV3	1941	Q8IVL0
PWSGGGVTKDITDTL	PRCP	431	P42785
GLASKTAAWGTLGTL	ANXA9	21	O76027
KIWLEGVVTTSAGGT	HPSE2	376	Q8WWQ2
AGPGKTSWEKGSLVS	PARP14	996	Q460N5
IGEGGDSGLTIEKSW	PLEKHG6	131	Q3KR16
KSGGVGGSNTNWKTL	RPA1	431	P27694
VIVGPSGAGKSTLWR	DYNC2H1	1976	Q8NCM8
GWGVTETGKGSRQLL	HABP2	451	Q14520
GLISASKAVGWGATQ	HIP1R	871	O75146
GKSTVGALLASELGW	IDNK	16	Q5T6J7
GWEGGTTAEGRLKQS	CCDC107	266	Q8WV48
ASLGSQKGGITKHGW	DOCK9	166	Q9BZ29
GLWTVFTLGGVGSKA	DYM	256	Q7RTS9
ISPGEGWTTGGATVI	EBF4	261	Q9BQW3
LAEKVFLSTTGGGWV	FMO1	206	Q01740
EVSGIKGGTTVVWVG	FSTL4	826	Q6MZW2
EWAVVTGSTDGIGKS	HSD17B12	51	Q53GQ0
GKGLEWVSAISGSGG	IGHV3-23	61	P01764
GSWVAAGLTIPVGKI	INSRR	426	P14616
KAISPSEGWTTGGAT	EBF3	266	Q9H4W6
SEGWTTGGATVIIIG	EBF3	271	Q9H4W6
AKSAGWTLATLGEQG	SCNN1D	636	P51172
GSAGKTFSVTGWKLG	KYAT3	276	Q6YP21
FPSSATGLKGGSWVV	NEURL4	116	Q96JN8
EILVKTGWGRGSGTT	PKD1	3121	P98161
WGGTGTVSRGKPLST	RTP5	176	Q14D33
GAASVKQTGTGWIGG	TNRC6C	681	Q9HCJ0
SKSLWDSASGGGVVA	TSC22D2	671	O75157
GLISASKAVGWGATV	HIP1	871	O00291
PETQTLTGWSKGFIG	RHOBTB1	366	O94844
IGTGDGWLLKAVSLG	SEMA4C	441	Q9C0C4
LSLVDWAKSGGTTGI	SETD1A	861	O15047
TKGAVGATIGGVAWI	TMEM263	46	Q8WUH6
GATIGGVAWIGGKSL	TMEM263	51	Q8WUH6
GVAWIGGKSLEVTKT	TMEM263	56	Q8WUH6
LTAGGSGGSWKLLTI	APEH	401	P13798
LESGDKTGVWTDTTG	XIRP2	1881	A4UGR9
NFSVTGGKWIVSGSE	WDR5B	261	Q86VZ2
LWGVGSALNKTGLST	UNC93B1	441	Q9H1C4
TAGEDGKVQVWSGSL	TEP1	1901	Q99973
KVAQTTGAWIITGGS	TRPM2	196	O94759
GWNKALGTESSTGPI	VPS18	146	Q9P253
GSTRVAKGWSQGVGE	FAM170A	36	A1A519
EGRWIKIGDVVGSSG	PLAA	371	Q9Y263
WGSTKTGEQDGLIGT	WAPL	946	Q7Z5K2
SVLVGKAAATGSGDW	PSEN2	371	P49810
EPGSSSVWVGGRGKV	SEMA7A	81	O75326
GGTVLSTNWSDVGKR	SUGT1	336	Q9Y2Z0
IGGLIIGWSSSEKKD	ZNF507	451	Q8TCN5
LDGKSWNPEGTVGTG	TLR4	816	O00206
GKSLLSGLATGESGW	WDR91	311	A4D1P6
FSVTGGKWIVSGSED	WDR5	266	P61964
SVWAKTGGTVESDGS	TNRC6A	661	Q8NDV7
IKAAVTTGAWILTGG	TRPM7	161	Q96QT4
KEGGTWLGISTRGKL	TANGO2	56	Q6ICL3