Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	pattern specification process	MEGF8 DLL4 GLI3 DCHS1 APC IRX2 RFX4 HAND2 AXIN2 DNAH11	1.78e-05	526	74	10	GO:0007389
GeneOntologyBiologicalProcess	dorsal/ventral pattern formation	DLL4 GLI3 APC RFX4 AXIN2	4.14e-05	107	74	5	GO:0009953
GeneOntologyBiologicalProcess	spinal cord dorsal/ventral patterning	DLL4 GLI3 RFX4	4.84e-05	20	74	3	GO:0021513
GeneOntologyBiologicalProcess	regionalization	MEGF8 DLL4 GLI3 APC IRX2 RFX4 HAND2 AXIN2 DNAH11	5.20e-05	478	74	9	GO:0003002
GeneOntologyBiologicalProcess	spinal cord patterning	DLL4 GLI3 RFX4	6.50e-05	22	74	3	GO:0021511
GeneOntologyBiologicalProcess	artery development	EFNB2 MEGF8 DLL4 GLI3 HAND2	1.17e-04	133	74	5	GO:0060840
GeneOntologyBiologicalProcess	epithelial tube morphogenesis	EFNB2 MEGF8 DLL4 GLI3 DCHS1 MAP3K7 IRX2 HAND2	1.31e-04	421	74	8	GO:0060562
GeneOntologyBiologicalProcess	heart morphogenesis	MEGF8 DLL4 DCHS1 APC HAND2 AXIN2 DNAH11	1.53e-04	321	74	7	GO:0003007
GeneOntologyBiologicalProcess	heart valve development	DLL4 DCHS1 APC AXIN2	1.78e-04	78	74	4	GO:0003170
HumanPheno	Foot oligodactyly	DLL4 GLI3 APC	2.66e-05	11	29	3	HP:0001849
HumanPheno	Fundic gland polyposis	APC AXIN2	3.13e-05	2	29	2	HP:0033769
MousePheno	abnormal anterior cardinal vein morphology	EFNB2 DLL4 GLI3	1.40e-05	11	63	3	MP:0004784
MousePheno	abnormal mitral valve morphology	EFNB2 MEGF8 DCHS1 DNAH11	3.35e-05	41	63	4	MP:0000286
MousePheno	abnormal myocardial trabeculae morphology	EFNB2 MEGF8 DLL4 MAP3K7 HAND2 DNAH11	4.51e-05	144	63	6	MP:0002189
Domain	Proteasome_bsu_C	PSMB7 PSMB10	1.59e-05	2	75	2	IPR024689
Domain	Pr_beta_C	PSMB7 PSMB10	1.59e-05	2	75	2	PF12465
Domain	Fox-1_C	RBFOX3 RBFOX1	4.76e-05	3	75	2	PF12414
Domain	RNA-bd_Fox-1	RBFOX3 RBFOX1	4.76e-05	3	75	2	IPR017325
Domain	Fox-1_C_dom	RBFOX3 RBFOX1	4.76e-05	3	75	2	IPR025670
Domain	Ephrin_RBD	EFNB2 EFNB3	4.39e-04	8	75	2	IPR001799
Domain	Ephrin	EFNB2 EFNB3	4.39e-04	8	75	2	PF00812
Domain	Ephrin	EFNB2 EFNB3	4.39e-04	8	75	2	PD002533
Domain	Ephrin	EFNB2 EFNB3	4.39e-04	8	75	2	IPR031328
Domain	EPHRIN_RBD_1	EFNB2 EFNB3	4.39e-04	8	75	2	PS01299
Domain	Ephrin_CS	EFNB2 EFNB3	4.39e-04	8	75	2	IPR019765
Domain	EPHRIN_RBD_2	EFNB2 EFNB3	4.39e-04	8	75	2	PS51551
Domain	Pept_T1A_subB	PSMB7 PSMB10	7.01e-04	10	75	2	IPR000243
Domain	BAH	TNRC18 BAHCC1	8.55e-04	11	75	2	SM00439
Domain	Proteasome_suB-type	PSMB7 PSMB10	8.55e-04	11	75	2	IPR023333
Domain	BAH	TNRC18 BAHCC1	8.55e-04	11	75	2	PF01426
Domain	BAH	TNRC18 BAHCC1	8.55e-04	11	75	2	PS51038
Domain	PROTEASOME_BETA_1	PSMB7 PSMB10	8.55e-04	11	75	2	PS00854
Domain	PROTEASOME_BETA_2	PSMB7 PSMB10	8.55e-04	11	75	2	PS51476
Domain	BAH_dom	TNRC18 BAHCC1	8.55e-04	11	75	2	IPR001025
Domain	Proteasome_bsu_CS	PSMB7 PSMB10	1.02e-03	12	75	2	IPR016050
Domain	bZIP_Maf	NFE2L3 NRL	1.21e-03	13	75	2	IPR004826
Domain	bZIP_Maf	NFE2L3 NRL	1.21e-03	13	75	2	PF03131
Domain	-	EFNB2 EFNB3	1.40e-03	14	75	2	2.60.40.420
Domain	Dynein_heavy_chain_D4_dom	DNAH1 DNAH11	1.40e-03	14	75	2	IPR024317
Domain	Dynein_HC_stalk	DNAH1 DNAH11	1.40e-03	14	75	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH1 DNAH11	1.40e-03	14	75	2	IPR013602
Domain	DHC_N2	DNAH1 DNAH11	1.40e-03	14	75	2	PF08393
Domain	MT	DNAH1 DNAH11	1.40e-03	14	75	2	PF12777
Domain	AAA_8	DNAH1 DNAH11	1.40e-03	14	75	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH1 DNAH11	1.40e-03	14	75	2	IPR011704
Domain	AAA_5	DNAH1 DNAH11	1.40e-03	14	75	2	PF07728
Domain	DHC_fam	DNAH1 DNAH11	1.62e-03	15	75	2	IPR026983
Domain	Dynein_heavy_dom	DNAH1 DNAH11	1.62e-03	15	75	2	IPR004273
Domain	Dynein_heavy	DNAH1 DNAH11	1.62e-03	15	75	2	PF03028
Domain	-	NFE2L3 NRL	1.84e-03	16	75	2	1.10.880.10
Domain	RRM_dom	RBMXL2 RBFOX3 RBFOX1 NXF2 BOLL	2.20e-03	227	75	5	IPR000504
Domain	PH	PLEKHG1 AFAP1 CNKSR2 IRS2 GAB2	2.28e-03	229	75	5	PF00169
Domain	RRM	RBMXL2 RBFOX3 RBFOX1 NXF2 BOLL	2.32e-03	230	75	5	PS50102
Domain	Proteasome	PSMB7 PSMB10	2.60e-03	19	75	2	PF00227
Domain	Proteasome_sua/b	PSMB7 PSMB10	2.60e-03	19	75	2	IPR001353
Domain	-	RBMXL2 RBFOX3 RBFOX1 NXF2 BOLL	3.00e-03	244	75	5	3.30.70.330
Domain	Cupredoxin	EFNB2 EFNB3	3.49e-03	22	75	2	IPR008972
Domain	Nucleotide-bd_a/b_plait	RBMXL2 RBFOX3 RBFOX1 NXF2 BOLL	3.80e-03	258	75	5	IPR012677
Domain	-	PSMB7 PSMB10	4.15e-03	24	75	2	3.60.20.10
Domain	PH	PLEKHG1 AFAP1 CNKSR2 IRS2 GAB2	5.21e-03	278	75	5	SM00233
Domain	PH_DOMAIN	PLEKHG1 AFAP1 CNKSR2 IRS2 GAB2	5.29e-03	279	75	5	PS50003
Domain	PH_domain	PLEKHG1 AFAP1 CNKSR2 IRS2 GAB2	5.37e-03	280	75	5	IPR001849
Domain	Ntn_hydrolases_N	PSMB7 PSMB10	7.75e-03	33	75	2	IPR029055
Pubmed	Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardium.	EFNB2 DLL4 IRX2 HAND2	2.40e-07	24	78	4	25497097
Pubmed	EphB6-null mutation results in compromised T cell function.	PTPRC EFNB2 EFNB3	9.03e-07	9	78	3	15599401
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PLEKHG1 FLNC TNRC18 MEGF8 SH3TC1 HELZ2 PSMB10 TMEM187 TBC1D25 IRS2 JADE1 ZDHHC8 BAHCC1	1.02e-06	1105	78	13	35748872
Pubmed	Increasing Sufu gene dosage reveals its unorthodox role in promoting polydactyly and medulloblastoma tumorigenesis.	RBFOX3 GLI3 HAND2	1.29e-06	10	78	3	38358805
Pubmed	Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme.	EFNB2 EFNB3 HAND2 AXIN2	2.23e-06	41	78	4	25139858
Pubmed	Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons.	SEC24D EFNB2 EFNB3 APC	2.46e-06	42	78	4	24997765
Pubmed	Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.	RBFOX3 EFNB2 EFNB3	3.88e-06	14	78	3	21460838
Pubmed	Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors.	RBFOX3 APC AXIN2	3.88e-06	14	78	3	21690300
Pubmed	Eph/Ephrin Signaling Controls Progenitor Identities In The Ventral Spinal Cord.	RBFOX3 EFNB2 EFNB3	4.84e-06	15	78	3	28595615
Pubmed	ETS factors regulate Vegf-dependent arterial specification.	EFNB2 DLL4 AXIN2	4.84e-06	15	78	3	23830865
Pubmed	Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.	APC AXIN2	4.97e-06	2	78	2	21982234
Pubmed	Molecular cloning of the mouse proteasome subunits MC14 and MECL-1: reciprocally regulated tissue expression of interferon-gamma-modulated proteasome subunits.	PSMB7 PSMB10	4.97e-06	2	78	2	9174609
Pubmed	Discerning intersecting fusion-activation pathways in the Nipah virus using machine learning.	EFNB2 EFNB3	4.97e-06	2	78	2	24615845
Pubmed	Lac z Histochemistry and immunohistochemistry reveal ephrin-B ligand expression in the inner ear.	EFNB2 EFNB3	4.97e-06	2	78	2	12486086
Pubmed	Inhibition of henipavirus infection by Nipah virus attachment glycoprotein occurs without cell-surface downregulation of ephrin-B2 or ephrin-B3.	EFNB2 EFNB3	4.97e-06	2	78	2	17251577
Pubmed	RBFOX1 and RBFOX3 mutations in rolandic epilepsy.	RBFOX3 RBFOX1	4.97e-06	2	78	2	24039908
Pubmed	Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors.	APC AXIN2	4.97e-06	2	78	2	11809809
Pubmed	Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control.	EFNB2 EFNB3	4.97e-06	2	78	2	11297511
Pubmed	Tumor-endothelial cell interaction in an experimental model of human hepatocellular carcinoma.	EFNB2 DLL4	4.97e-06	2	78	2	30205087
Pubmed	Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.	DNAH1 DNAH11	4.97e-06	2	78	2	24360805
Pubmed	The role of Delta-like 4 ligand/Notch-ephrin-B2 cascade in the pathogenesis of preeclampsia by regulating functions of endothelial progenitor cell.	EFNB2 DLL4	4.97e-06	2	78	2	26212082
Pubmed	Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade.	EFNB2 DLL4	4.97e-06	2	78	2	19218547
Pubmed	Delta-like 4/Notch signaling promotes Apc Min/+ tumor initiation through angiogenic and non-angiogenic related mechanisms.	DLL4 APC	4.97e-06	2	78	2	28086833
Pubmed	The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.	EFNB2 DLL4 AXIN2	1.02e-05	19	78	3	20627076
Pubmed	Differential Clinical Features in Colombian Patients With Rolandic Epilepsy and Suggestion of Unlikely Association With GRIN2A, RBFOX1, or RBFOX3 Gene Variants.	RBFOX3 RBFOX1	1.49e-05	3	78	2	34039076
Pubmed	Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo.	EFNB2 EFNB3	1.49e-05	3	78	2	11182082
Pubmed	Kaiso overexpression promotes intestinal inflammation and potentiates intestinal tumorigenesis in Apc(Min/+) mice.	APC AXIN2	1.49e-05	3	78	2	26073433
Pubmed	Hippocampal plasticity requires postsynaptic ephrinBs.	EFNB2 EFNB3	1.49e-05	3	78	2	14699416
Pubmed	Coexpression of ephrin-Bs and their receptors in colon carcinoma.	EFNB2 EFNB3	1.49e-05	3	78	2	11920461
Pubmed	Rbfox family proteins make the homo- and hetero-oligomeric complexes.	RBFOX3 RBFOX1	1.49e-05	3	78	2	29170129
Pubmed	Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly.	RBFOX3 RBFOX1	1.49e-05	3	78	2	29398366
Pubmed	Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma.	APC AXIN2	1.49e-05	3	78	2	18384130
Pubmed	Regulation of APC and AXIN2 expression by intestinal tumor suppressor CDX2 in colon cancer cells.	APC AXIN2	1.49e-05	3	78	2	23393221
Pubmed	The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions.	EFNB2 DLL4	1.49e-05	3	78	2	16951162
Pubmed	Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2.	EFNB2 EFNB3	1.49e-05	3	78	2	15047175
Pubmed	Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS.	RBFOX3 EFNB2 EFNB3	1.86e-05	23	78	3	24360543
Pubmed	Rheb1 is required for mTORC1 and myelination in postnatal brain development.	RBFOX3 APC IRS2	2.41e-05	25	78	3	21238928
Pubmed	Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements.	EFNB2 GLI3 HAND2	2.41e-05	25	78	3	25848055
Pubmed	APC controls asymmetric Wnt/β-catenin signaling and cardiomyocyte proliferation gradient in the heart.	APC HAND2 AXIN2	2.72e-05	26	78	3	26493106
Pubmed	Association of XIST/miRNA155/Gab2/TAK1 cascade with the pathogenesis of anti-phospholipid syndrome and its effect on cell adhesion molecules and inflammatory mediators.	MAP3K7 GAB2	2.97e-05	4	78	2	37914735
Pubmed	Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.	DNAH1 DNAH11	2.97e-05	4	78	2	18492703
Pubmed	Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals.	RBFOX3 RBFOX1	2.97e-05	4	78	2	16260614
Pubmed	Eph/ephrinB signalling is involved in the survival of thymic epithelial cells.	EFNB2 EFNB3	2.97e-05	4	78	2	23146940
Pubmed	EphB2 and EphB3 play an important role in the lymphoid seeding of murine adult thymus.	EFNB2 EFNB3	2.97e-05	4	78	2	25810451
Pubmed	Molecular motors: the driving force behind mammalian left-right development.	DNAH1 DNAH11	2.97e-05	4	78	2	10652513
Pubmed	Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer.	APC AXIN2	2.97e-05	4	78	2	24609463
Pubmed	EphB receptors and ephrin-B3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cord.	EFNB2 EFNB3	2.97e-05	4	78	2	16943546
Pubmed	Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice.	PTPRC PSMB10	2.97e-05	4	78	2	21108466
Pubmed	Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-β-catenin signalling.	APC AXIN2	2.97e-05	4	78	2	24251807
Pubmed	A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses.	EFNB2 EFNB3	2.97e-05	4	78	2	21964490
Pubmed	Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma.	PSMB7 PSMB10	2.97e-05	4	78	2	8666937
Pubmed	RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts.	RBFOX3 RBFOX1	2.97e-05	4	78	2	25524026
Pubmed	5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation.	APC AXIN2	2.97e-05	4	78	2	33087710
Pubmed	Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon.	APC AXIN2	2.97e-05	4	78	2	12072559
Pubmed	Fox-3 and PSF interact to activate neural cell-specific alternative splicing.	RBFOX3 RBFOX1	4.94e-05	5	78	2	21177649
Pubmed	The Shh/Gli3 gene regulatory network precedes the origin of paired fins and reveals the deep homology between distal fins and digits.	GLI3 HAND2	4.94e-05	5	78	2	34750251
Pubmed	A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.	APC EIF2A	4.94e-05	5	78	2	31685988
Pubmed	Developmental control of CaV1.2 L-type calcium channel splicing by Fox proteins.	RBFOX3 RBFOX1	4.94e-05	5	78	2	19564422
Pubmed	Hot spots in beta-catenin for interactions with LEF-1, conductin and APC.	APC AXIN2	4.94e-05	5	78	2	10966653
Pubmed	EphB2 and ephrin-B2 regulate the ionic homeostasis of vestibular endolymph.	EFNB2 EFNB3	4.94e-05	5	78	2	17158005
Pubmed	Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.	APC AXIN2	4.94e-05	5	78	2	9554852
Pubmed	Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling.	GLI3 AXIN2	4.94e-05	5	78	2	17331723
Pubmed	Expression pattern of Irx1 and Irx2 during mouse digit development.	GLI3 IRX2	4.94e-05	5	78	2	11472848
Pubmed	The role of primary cilia in corpus callosum formation is mediated by production of the Gli3 repressor.	RBFOX3 GLI3 AXIN2	5.64e-05	33	78	3	26071364
Pubmed	Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities.	RBFOX3 GLI3 RFX4	5.64e-05	33	78	3	30914320
Pubmed	Regulation of PERK-eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes.	RBFOX3 APC EIF2A	5.64e-05	33	78	3	27416896
Pubmed	GLI2 Modulated by SUFU and SPOP Induces Intestinal Stem Cell Niche Signals in Development and Tumorigenesis.	GLI3 APC AXIN2	6.74e-05	35	78	3	31167144
Pubmed	Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity.	EFNB2 DLL4 HAND2	6.74e-05	35	78	3	29540665
Pubmed	Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants.	EFNB2 DLL4	7.40e-05	6	78	2	15466160
Pubmed	Dosage-sensitive requirement for mouse Dll4 in artery development.	EFNB2 DLL4	7.40e-05	6	78	2	15466159
Pubmed	Genetic and molecular control of folate-homocysteine metabolism in mutant mice.	GLI3 APC	7.40e-05	6	78	2	12016514
Pubmed	Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation.	IRS2 GAB2	7.40e-05	6	78	2	12506011
Pubmed	Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice.	APC AXIN2	7.40e-05	6	78	2	31924786
Pubmed	Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function.	GLI3 HAND2	7.40e-05	6	78	2	15973411
Pubmed	Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.	APC AXIN2	7.40e-05	6	78	2	21113151
Pubmed	Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos.	EFNB2 DLL4	7.40e-05	6	78	2	18550715
Pubmed	Crystal structure of an ephrin ectodomain.	EFNB2 EFNB3	7.40e-05	6	78	2	11703926
Pubmed	Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis.	APC AXIN2	7.40e-05	6	78	2	28870287
Pubmed	Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4.	EFNB2 EFNB3	7.40e-05	6	78	2	9630219
Pubmed	Ephrin B1 is expressed on neuroepithelial cells in correlation with neocortical neurogenesis.	EFNB2 EFNB3	7.40e-05	6	78	2	11306625
Pubmed	LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis.	APC AXIN2	7.40e-05	6	78	2	30224759
Pubmed	Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer.	APC AXIN2	7.40e-05	6	78	2	18708403
Pubmed	Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments.	EFNB2 EFNB3	7.40e-05	6	78	2	8808709
Pubmed	Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog ( Shh).	GLI3 HAND2	7.40e-05	6	78	2	14727139
Pubmed	Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage.	PTPRC APC	7.40e-05	6	78	2	25393502
Pubmed	Abnormal hippocampal axon bundling in EphB receptor mutant mice.	EFNB2 EFNB3	7.40e-05	6	78	2	15014111
Pubmed	Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium.	APC AXIN2	7.40e-05	6	78	2	26528816
Pubmed	Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb.	GLI3 HAND2	7.40e-05	6	78	2	15677727
Pubmed	Reelin induces EphB activation.	EFNB2 EFNB3	7.40e-05	6	78	2	23318582
Pubmed	EphB2 and EphB3 forward signalling are required for palate development.	EFNB2 EFNB3	7.40e-05	6	78	2	19032981
Pubmed	Irx1 and Irx2 expression in early lung development.	GLI3 IRX2	7.40e-05	6	78	2	11472847
Pubmed	Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.	EFNB2 DLL4 HAND2	8.65e-05	38	78	3	29743679
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	MEGF8 COQ8A MBOAT7 LINC00299 TBC1D25 DDX51 IRS2 DNAH11	9.31e-05	638	78	8	31182584
Pubmed	The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning.	GLI3 HAND2 AXIN2	1.01e-04	40	78	3	21256124
Pubmed	Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling.	GLI3 HAND2	1.04e-04	7	78	2	11850405
Pubmed	A dual role for Hox genes in limb anterior-posterior asymmetry.	GLI3 HAND2	1.04e-04	7	78	2	15192229
Pubmed	Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues.	EFNB2 EFNB3	1.04e-04	7	78	2	21539827
Pubmed	Autonomous and non-autonomous roles for ephrin-B in interneuron migration.	EFNB2 EFNB3	1.04e-04	7	78	2	28947178
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH1 DNAH11	1.04e-04	7	78	2	9256245
Pubmed	Zic2 Controls the Migration of Specific Neuronal Populations in the Developing Forebrain.	EFNB2 EFNB3	1.04e-04	7	78	2	26269635
Cytoband	20q13.33	SAMD10 HELZ2 FAM217B	3.40e-04	79	78	3	20q13.33
Cytoband	17q25.3	ZNF750 RBFOX3 BAHCC1	6.97e-04	101	78	3	17q25.3
GeneFamily	Ephrins	EFNB2 EFNB3	2.16e-04	8	51	2	546
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG1 AFAP1 CNKSR2 IRS2 GAB2	2.81e-04	206	51	5	682
GeneFamily	Dyneins, axonemal	DNAH1 DNAH11	1.03e-03	17	51	2	536
GeneFamily	RNA binding motif containing	RBMXL2 RBFOX3 RBFOX1 BOLL	3.04e-03	213	51	4	725
GeneFamily	Proteasome	PSMB7 PSMB10	6.54e-03	43	51	2	690
GeneFamily	Basic leucine zipper proteins	NFE2L3 NRL	8.43e-03	49	51	2	506
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#5_top-relative-expression-ranked_100	NFE2L3 CLCA2 ACTG2	4.04e-07	5	74	3	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k5_100
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#5_top-relative-expression-ranked_100	NFE2L3 CLCA2 ACTG2	1.41e-06	7	74	3	gudmap_developingLowerUrinaryTract_e14.5_ urethra_100_k5
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RBFOX3 FSTL5 RBFOX1 BEST3 LINC00299 RFX4	5.65e-07	171	78	6	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	droplet-Marrow-nan-18m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MEGF8 SH3TC1 ZDHHC8 DNAH1 BAHCC1	1.37e-05	174	78	5	55cc8300489d11322724159ec7d0e1d32a702e91
ToppCell	severe-Myeloid-Neutrophils_1\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PTPRC MBOAT7 IRS2 GAB2 TG	1.75e-05	183	78	5	60a6112aa4fc4f5debda4c7e81b37539ba2e4e6e
ToppCell	cellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PLEKHG1 SAMD10 DCHS1 ZDHHC8 FBXL4	2.04e-05	189	78	5	bccb3481ffed597c845fe860da658505316105b5
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC ACTG2 CACNA1G INPP5J FBXL4	2.04e-05	189	78	5	4dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC ACTG2 CACNA1G INPP5J FBXL4	2.04e-05	189	78	5	0d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCell	11.5-Airway-Epithelial-Neuroendocrine\|Airway / Age, Tissue, Lineage and Cell class	DLL4 RBFOX1 BEST3 SLC16A11 HEPACAM2	2.15e-05	191	78	5	c1bb3ae5c297f55cdadf5b6e53d5296389d5099e
ToppCell	distal-3-Epithelial-Ionocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZNF750 EFNB3 BEST3 HEPACAM2 INPP5J	2.43e-05	196	78	5	6ed146481dd04fb271eadc47d68eb3ae38986db6
ToppCell	distal-Epithelial-Ionocyte\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZNF750 EFNB3 BEST3 HEPACAM2 INPP5J	2.49e-05	197	78	5	11a5d2db2561d045756980ead61e1211c7dda100
ToppCell	distal-Epithelial-Ionocyte-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZNF750 EFNB3 BEST3 HEPACAM2 INPP5J	2.49e-05	197	78	5	7a2cd970fe0866057999e40d15367b2b3324ae59
ToppCell	distal-mesenchymal-Mesothelial-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FLNC MELTF GLI3 RBFOX1 HAND2	2.55e-05	198	78	5	431bf719ee5cce4c9e8b6b405819b67e98fad3ca
ToppCell	distal-mesenchymal-Mesothelial\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FLNC MELTF GLI3 RBFOX1 HAND2	2.55e-05	198	78	5	52e3cb45472dd6db31ae533e9ea0c3b550f11496
ToppCell	distal-1-mesenchymal-Mesothelial\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FLNC MELTF GLI3 RBFOX1 HAND2	2.61e-05	199	78	5	8dd5b411d2f1626830b77a1616cc3fb67dc59338
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-OPC_related\|6m / Sample Type, Dataset, Time_group, and Cell type.	FLNC COQ8A VGLL2 KANK4 BEST3	2.68e-05	200	78	5	ea1e3eeddbc398ac97863120f7aa3f17569ca12a
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-OPC_related-Oligodendrocyte/OPC\|6m / Sample Type, Dataset, Time_group, and Cell type.	FLNC COQ8A VGLL2 KANK4 BEST3	2.68e-05	200	78	5	4a57f2f2dc6e2402ac4772b5cd38e033a6f1adee
Drug	Remoxipride Hydrochloride [73220-03-8]; Up 200; 9.8uM; MCF7; HT_HG-U133A	ZNF750 EFNB3 SH3TC1 AP5Z1 RBFOX1 APC IRS2 KDM8	3.23e-07	198	76	8	5443_UP
Drug	Mefenamic acid [61-68-7]; Up 200; 16.6uM; MCF7; HT_HG-U133A	MBOAT7 RBFOX1 APC CACNA1G IRS2 KDM8 INPP5J	4.60e-06	199	76	7	5534_UP
Drug	MEHP	EHHADH FSHB APC AXIN2	2.35e-05	50	76	4	CID000020393
Drug	Leucovorin	FSHB BOLL HAND2 AXIN2	3.69e-05	56	76	4	ctd:D002955
Drug	Althiazide [5588-16-9]; Up 200; 10.4uM; HL60; HT_HG-U133A	FLNC EFNB3 CLCA2 RBFOX1 CACNA1G INPP5J	4.72e-05	194	76	6	2527_UP
Drug	Galanthamine hydrobromide [1953-04-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A	CLCA2 SH3TC1 APC ACTG2 CACNA1G KDM8	5.00e-05	196	76	6	4772_UP
Drug	Azathymine, 6 [932-53-6]; Up 200; 31.4uM; MCF7; HT_HG-U133A	EFNB3 SH3TC1 FSHB RBFOX1 CNKSR2 TG	5.00e-05	196	76	6	4106_UP
Drug	Medrysone [2668-66-8]; Up 200; 11.6uM; PC3; HT_HG-U133A	MELTF MEGF8 CLCA2 AP5Z1 RBFOX1 APC	5.14e-05	197	76	6	4266_UP
Drug	Flavoxate hydrochloride [3717-88-2]; Up 200; 9.4uM; MCF7; HT_HG-U133A	AFAP1 MBOAT7 AP5Z1 DDX51 KDM8 BAHCC1	5.29e-05	198	76	6	5427_UP
Drug	Bergenin monohydrate [477-90-7]; Up 200; 11.6uM; PC3; HT_HG-U133A	CLCA2 RBFOX1 ACTG2 MMP10 INPP5J BAHCC1	5.29e-05	198	76	6	5870_UP
Drug	Bezafibrate [41859-67-0]; Up 200; 11uM; MCF7; HT_HG-U133A	ZNF750 SEC24D EFNB3 MBOAT7 APC INPP5J	5.29e-05	198	76	6	4999_UP
Drug	Pivmecillinam hydrochloride [32887-03-9]; Down 200; 8.4uM; MCF7; HT_HG-U133A	ZNF750 FLNC SEC24D ACTG2 KDM8 INPP5J	5.44e-05	199	76	6	3535_DN
Drug	Methapyrilene hydrochloride [135-23-9]; Up 200; 13.4uM; MCF7; HT_HG-U133A	SEC24D NRL APC CNKSR2 IRS2 INPP5J	5.44e-05	199	76	6	4990_UP
Drug	PF-00562151-00 [351320-12-2]; Down 200; 10uM; MCF7; HT_HG-U133A	AFAP1 MEGF8 EHHADH AP5Z1 FSHB APC	5.59e-05	200	76	6	5917_DN
Disease	Colorectal Carcinoma	FLNC SH3TC1 TOMM40L GLI3 FSTL5 DCHS1 APC CNKSR2 BOLL AXIN2	1.26e-05	702	76	10	C0009402
Disease	varicose veins (is_marker_for)	EFNB2 DLL4	9.75e-05	6	76	2	DOID:799 (is_marker_for)
Disease	gallbladder cancer (is_implicated_in)	APC AXIN2	5.01e-04	13	76	2	DOID:3121 (is_implicated_in)
Disease	receptive language perception, parental genotype effect measurement	PLEKHG1 ACTG2	5.84e-04	14	76	2	EFO_0005686, EFO_0005939
Disease	Colorectal Neoplasms	FLNC SH3TC1 APC BOLL AXIN2	7.54e-04	277	76	5	C0009404
Disease	lower body strength measurement	RBFOX3 RBFOX1	7.67e-04	16	76	2	EFO_0007999
Disease	Benign neoplasm of stomach	APC AXIN2	8.68e-04	17	76	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	APC AXIN2	8.68e-04	17	76	2	C0496905
Disease	Carcinoma in situ of stomach	APC AXIN2	8.68e-04	17	76	2	C0154060
Disease	intellectual disability (implicated_via_orthology)	RBFOX3 RBFOX1 IRS2	9.70e-04	75	76	3	DOID:1059 (implicated_via_orthology)
Disease	Stomach Neoplasms	GLI3 APC IRS2 MMP10 AXIN2	1.03e-03	297	76	5	C0038356
Disease	Malignant neoplasm of stomach	GLI3 APC IRS2 MMP10 AXIN2	1.08e-03	300	76	5	C0024623
Disease	urate measurement, bone density	FSTL5 RBFOX1 HELZ2 FBXL4 DNAH1 DNAH11 TG	1.08e-03	619	76	7	EFO_0003923, EFO_0004531
Disease	Left Ventricle Remodeling	HAND2 AXIN2	1.33e-03	21	76	2	C0600520
Disease	Ventricular Remodeling	HAND2 AXIN2	1.33e-03	21	76	2	C0600519
Disease	Stomach Carcinoma	APC AXIN2	1.33e-03	21	76	2	C0699791
Disease	level of Phosphatidylinositol (18:0_20:4) in blood serum	MBOAT7 KANK4	1.60e-03	23	76	2	OBA_2045158
Disease	neuroimaging measurement	PLEKHG1 AFAP1 GLI3 APC CNKSR2 MAP3K7 BAHCC1 DNAH11 TG	1.68e-03	1069	76	9	EFO_0004346
Disease	Colorectal cancer	APC AXIN2	2.20e-03	27	76	2	cv:C0346629
Disease	COLORECTAL CANCER	APC AXIN2	2.20e-03	27	76	2	114500
Disease	Neoplasm of the large intestine	APC AXIN2	2.20e-03	27	76	2	cv:C0009404
Disease	cortical surface area measurement	PLEKHG1 AFAP1 EFNB2 GLI3 APC AKIP1 MAP3K7 RFX4 DNAH11 TG	2.32e-03	1345	76	10	EFO_0010736
Disease	preterm premature rupture of the membranes, spontaneous preterm birth	FSTL5 CNKSR2	2.37e-03	28	76	2	EFO_0006917, MONDO_0012511
Disease	cardiac troponin T measurement	GLI3 RBFOX1 PSMB7 IRX2	2.49e-03	219	76	4	EFO_0005043

Protein segments in the cluster

Peptide	Gene	Start	Entry
TAAEAPVPTSGGYHH	BEST3	506	Q8N1M1
PALSGHSIDYHFYPR	LINC00299	76	Q6ZSB3
PDHAAPYGVSYAHLK	BAHCC1	431	Q9P281
PTPGHYHVLYRGCGE	DPEP2NB	31	A0A0U1RQF7
VPEPYSDHGVQATYH	BOLL	241	Q8N9W6
YAHPSGTALHYDDVP	AFAP1	491	Q8N556
SVPEEGGATHVYRYH	AKIP1	106	Q9NQ31
PPGYYGLHCEHSTLS	DLL4	351	Q9NR61
EDYGHPPREGAYLHG	DNAH11	4416	Q96DT5
NPYHIGSGYVFAPAT	AXIN2	281	Q9Y2T1
THNVPIYEGYALPHA	ACTG2	161	P63267
YPAPGYAAGVHSVLS	AP5Z1	591	O43299
HDTAISGPLHYAPYH	RFX4	626	Q33E94
YAAADPYHHTIGPAA	RBFOX3	291	A6NFN3
PYHHTIGPAATYSIG	RBFOX3	296	A6NFN3
VDVTGPHLYSIYPHG	PSMB7	146	Q99436
YSFDGPGHSLAHAYP	MMP10	171	P09238
HLYHQTLPSYGGPGA	DCHS1	3001	Q96JQ0
GGYFVPYVHLAPHAL	SLC16A11	256	Q8NCK7
DAPHAGVSPAEYYHQ	GLI3	226	P10071
YSPQESGALYPHDTH	KDM8	341	Q8N371
ASPEHIDVVYLHGYG	EHHADH	641	Q08426
CPHYEKVSGDYGHPV	EFNB2	301	P52799
YFDLHPGQGHTKPEY	FAM217B	126	Q9NTX9
SSHHDLEGAVGGYYP	NFE2L3	456	Q9Y4A8
HGYYPGSPEETGAQH	NRL	111	P54845
HTVHYTPATDGPYTV	FLNC	1501	Q14315
LHGAEPLPYYTAAHA	MAP3K7	116	O43318
GTPPTGLYGHSAVYH	MEGF8	1666	Q7Z7M0
HGLHPGYYLSFLTIP	MBOAT7	356	Q96N66
VPGCAHHADSLYTYP	FSHB	81	P01225
AHPLESHYRSPGGGY	IRX2	436	Q9BZI1
SDVTGTPYVSPDGHY	FSTL5	691	Q8N475
PEYASGAAGLDHSHY	HAND2	66	P61296
HPYPEDYGDIEIGSH	IRS2	626	Q9Y4H2
HSYSASGIYHQIPPT	DNAH1	3911	Q9P2D7
SGIYHQIPPTYDLHG	DNAH1	3916	Q9P2D7
PPGGAESVHSFYHAD	CACNA1G	546	O43497
GKYAFPVGLTHHYVP	DDX51	471	Q8N8A6
YPTAVHVLETYHPGA	FBXL4	136	Q9UKA2
SLGHAHSEGPAPAYV	COQ8A	106	Q8NI60
PGDCLIYPAHDYHGF	ETHE1	186	O95571
KSHPYSVETPYGFHL	KANK4	21	Q5T7N3
GQALYLPVHYGFHTP	HEPACAM2	46	A8MVW5
YYSPHGHILVLAGFG	EIF2A	321	Q9BY44
YFHSHVSGGHPEATP	HELZ2	586	Q9BYK8
PFCPHYEKVSGDYGH	EFNB3	306	Q15768
PAYNHGRHPLYLTGF	PTCHD3	286	Q3KNS1
YEHGGYERPPSHCQE	NXF2	46	Q9GZY0
PGAHHFDSLGYPSTT	GAB2	481	Q9UQC2
PYHHALAPAPTYGVG	RBFOX1	341	Q9NWB1
YYAGPEDGPHLRALH	TBC1D25	301	Q3MII6
TYGLVPAAGEHYAPE	MELTF	431	P08582
PISHHYYDNVLPFSG	ST8SIA1	306	Q92185
SDHYGLYHTSPSLGG	SAMD10	96	Q9BYL1
GPLYTSLAQLYSHHG	SH3TC1	786	Q8TE82
GPQLYGVHPHGSYSR	PSMB10	146	P40306
HQHSDYPYLGLGRVP	JADE1	771	Q6IE81
FAPSPGEYTHRDYGH	RBMXL2	231	O75526
EAVPYAHYEHLGTPF	NCKIPSD	516	Q9NZQ3
LSPPHYGHYGDPSHT	SEC24D	21	O94855
YGHYGDPSHTASPTG	SEC24D	26	O94855
DSPHHYTPIEGTPYC	APC	1841	P25054
AHSIPGSHAMYVPGY	CLCA2	701	Q9UQC9
HLQDHYGPYPLAESE	CNKSR2	816	Q8WXI2
YGPYSAAGLPVEHHT	C10orf53	11	Q8N6V4
LPKGHGDFILGYYSH	INPP5J	811	Q15735
HAHEGFSHLPSGLYP	TNRC18	111	O15417
EYPPHFYTEHGLATI	ZNF750	241	Q32MQ0
FAAADPYSPAALHGH	VGLL2	171	Q8N8G2
AGVGAVLLFHYYTHP	SERINC4	236	A6NH21
DGPRHDTYILYYSGH	TMEM168	491	Q9H0V1
TRPYGFGLNHGHTPY	SLC30A6	406	Q6NXT4
GYEHYAEAPVAGLPA	TMEM187	36	Q14656
LGLPGYHLHAAYAGD	TOMM40L	71	Q969M1
VAGYHSPYLHPGATG	ZDHHC8	501	Q9ULC8
EAPYHQATPDHGYLS	PLEKHG1	796	Q9ULL1
LGIYDADPAHHRGTY	VSIG10L2	561	P0DP72
YPGEPFILHHSTSYN	PTPRC	561	P08575
YHAPENYGHGSLELL	TG	2611	P01266
DSYAPYELHGPHAAP	THEGL	96	P0DJG4
YSYHHPSSAGVDLGA	KRT74	471	Q7RTS7