Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

RNF10 TRIM8 RNF151 TRIM45 LONRF2 OBI1

5.63e-04473446GO:0004842
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

RNF10 TRIM8 RNF151 TRIM45 LONRF2 OBI1

8.52e-04512446GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

RNF10 TRIM8 RNF151 TRIM45 LONRF2 OBI1

1.04e-03532446GO:0016755
GeneOntologyMolecularFunctionubiquitin protein ligase activity

RNF10 TRIM8 RNF151 TRIM45 LONRF2

1.31e-03372445GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

RNF10 TRIM8 RNF151 TRIM45 LONRF2

1.76e-03398445GO:0061659
GeneOntologyMolecularFunctionprotein kinase regulator activity

CCNO ALS2 CCNB3 TRIB1

2.50e-03259444GO:0019887
GeneOntologyMolecularFunctionprotein kinase binding

TRIM8 RHOBTB1 TRIB1 RHOU RHOBTB2 AXIN1 FIZ1

2.78e-03873447GO:0019901
GeneOntologyMolecularFunctiontranscription coactivator activity

TRIM8 ACSS2 FIZ1 NPAT

4.38e-03303444GO:0003713
GeneOntologyMolecularFunctionkinase regulator activity

CCNO ALS2 CCNB3 TRIB1

4.48e-03305444GO:0019207
GeneOntologyBiologicalProcessCdc42 protein signal transduction

RHOBTB1 RHOU RHOBTB2

5.62e-0617433GO:0032488
Domainzf-C3HC4

RNF10 TRIM8 RNF151 TRIM45 LONRF2 OBI1

1.31e-05223446PF00097
DomainRHO

RHOBTB1 RHOU RHOBTB2

1.35e-0520443PS51420
DomainPeptidase_M12B_ADAM-TS

ADAMTSL1 ADAMTS13 ADAMTS6

2.39e-0524443IPR013273
DomainZnf_RING_CS

RNF10 TRIM8 RNF151 TRIM45 LONRF2

3.93e-05163445IPR017907
DomainZF_RING_1

RNF10 TRIM8 RNF151 TRIM45 LONRF2 OBI1

5.83e-05291446PS00518
DomainZF_RING_2

RNF10 TRIM8 RNF151 TRIM45 LONRF2 OBI1

6.65e-05298446PS50089
DomainRING

RNF10 TRIM8 RNF151 TRIM45 LONRF2 OBI1

7.56e-05305446SM00184
DomainZnf_RING

RNF10 TRIM8 RNF151 TRIM45 LONRF2 OBI1

1.09e-04326446IPR001841
DomainTSP_1

ADAMTSL1 ADAMTS13 ADAMTS6

4.39e-0463443PF00090
DomainTSP1

ADAMTSL1 ADAMTS13 ADAMTS6

4.81e-0465443SM00209
DomainTSP1_rpt

ADAMTSL1 ADAMTS13 ADAMTS6

4.81e-0465443IPR000884
DomainTSP1

ADAMTSL1 ADAMTS13 ADAMTS6

4.81e-0465443PS50092
DomainPLAC

ADAMTSL1 ADAMTS6

4.85e-0414442PF08686
Domain-

RNF10 TRIM8 RNF151 TRIM45 LONRF2 OBI1

6.08e-044494463.30.40.10
DomainZnf_RING/FYVE/PHD

RNF10 TRIM8 RNF151 TRIM45 LONRF2 OBI1

6.82e-04459446IPR013083
DomainCyclin_C

CCNO CCNB3

7.21e-0417442PF02984
DomainCyclin_C-dom

CCNO CCNB3

7.21e-0417442IPR004367
DomainCyclin_C

CCNO CCNB3

7.21e-0417442SM01332
DomainPLAC

ADAMTSL1 ADAMTS6

9.04e-0419442PS50900
DomainPLAC

ADAMTSL1 ADAMTS6

9.04e-0419442IPR010909
DomainZINC_PROTEASE

ADAMTS13 ADAMTS6 AMZ1

1.59e-0398443PS00142
DomainCYCLINS

CCNO CCNB3

1.97e-0328442PS00292
DomainCyclin_N

CCNO CCNB3

2.73e-0333442IPR006671
DomainCyclin_N

CCNO CCNB3

2.73e-0333442PF00134
DomainZnf-RING_LisH

TRIM45 LONRF2

2.90e-0334442IPR027370
Domainzf-RING_UBOX

TRIM45 LONRF2

2.90e-0334442PF13445
DomainCYCLIN

CCNO CCNB3

3.61e-0338442SM00385
DomainDISINTEGRIN_1

ADAMTS13 ADAMTS6

4.00e-0340442PS00427
Domain-

CCNO CCNB3

4.00e-03404421.10.472.10
DomainReprolysin

ADAMTS13 ADAMTS6

4.00e-0340442PF01421
DomainADAM_MEPRO

ADAMTS13 ADAMTS6

4.00e-0340442PS50215
DomainDISINTEGRIN_2

ADAMTS13 ADAMTS6

4.00e-0340442PS50214
DomainPeptidase_M12B

ADAMTS13 ADAMTS6

4.00e-0340442IPR001590
DomainRas

RHOBTB1 RHOU RHOBTB2

4.02e-03136443PF00071
DomainDisintegrin_dom

ADAMTS13 ADAMTS6

4.20e-0341442IPR001762
DomainCyclin-like

CCNO CCNB3

4.61e-0343442IPR013763
DomainSmall_GTPase

RHOBTB1 RHOU RHOBTB2

6.32e-03160443IPR001806
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTSL1 ADAMTS13 ADAMTS6

1.01e-0439333M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTSL1 ADAMTS13 ADAMTS6

1.01e-0439333MM15165
PathwayREACTOME_O_LINKED_GLYCOSYLATION

LARGE2 ADAMTSL1 ADAMTS13 ADAMTS6

1.16e-04109334MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

LARGE2 ADAMTSL1 ADAMTS13 ADAMTS6

1.25e-04111334M27416
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTSL1 ADAMTS13 ADAMTS6

5.28e-0468333M27303
Pubmed

Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis.

RHOBTB1 RHOBTB2

4.69e-06344227314390
Pubmed

The Dictyostelium discoideum family of Rho-related proteins.

RHOBTB1 RHOBTB2

4.69e-06344211222756
Pubmed

Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse.

RHOBTB1 RHOBTB2

4.69e-06344212426103
Pubmed

Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism.

RHOBTB1 RHOBTB2

1.56e-05544218835386
Pubmed

Rho GTPases have diverse effects on the organization of the actin filament system.

RHOBTB1 RHOU

1.56e-05544214521508
Pubmed

MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.

RHOBTB1 RHOBTB2

2.34e-05644222709582
Pubmed

Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain.

RHOBTB1 RHOBTB2

4.36e-05844224923387
Pubmed

ADAMTS: a novel family of extracellular matrix proteases.

ADAMTS13 ADAMTS6

6.99e-051044211167130
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

EEFSEC REV3L AASS BCKDK

1.14e-0419744420811636
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTSL1 ADAMTS13 ADAMTS6

1.20e-047544320637190
Pubmed

Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.

DLGAP2 TRIB1

1.86e-041644224886709
Pubmed

A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects.

NPLOC4 AXIN1

2.93e-042044234127677
Pubmed

STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.

OBI1 TRIB1

7.11e-043144228089446
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

RNF10 TRIM45 NEK3 HMGXB3 MAU2 RHOU NPLOC4

8.78e-04124244730973865
Pubmed

DNA sequence and analysis of human chromosome 9.

ACTL7A ADAMTSL1 ADAMTS13 ECPAS

1.22e-0337044415164053
Cytoband10q23

RGR PLCE1

6.96e-051344210q23
GeneFamilyRho family GTPases

RHOBTB1 RHOU RHOBTB2

4.61e-0620303390
GeneFamilyRing finger proteins

RNF10 TRIM8 RNF151 TRIM45 LONRF2 OBI1

5.12e-0627530658
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS13 ADAMTS6

4.47e-041930250
GeneFamilyCyclins

CCNO CCNB3

9.79e-0428302473
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM8 TRIM45

1.08e-029530259
GeneFamilyBasic leucine zipper proteins|BTB domain containing

RHOBTB1 RHOBTB2

2.07e-02134302861
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

SPOCD1 AXIN1

3.61e-02181302694
CoexpressionGSE45365_WT_VS_IFNAR_KO_BCELL_UP

ACSS2 LONRF2 AASS RHOBTB2 NPAT

1.86e-05195445M9984
CoexpressionGSE39820_CTRL_VS_TGFBETA3_IL6_IL23A_CD4_TCELL_DN

CCNO EEFSEC RHOBTB1 NPLOC4 FIZ1

2.05e-05199445M5614
Diseasedevelopmental and epileptic encephalopathy 64 (implicated_via_orthology)

RHOBTB1 RHOBTB2

1.98e-062422DOID:0070375 (implicated_via_orthology)
Diseaseacetate measurement

ACSS2 TRIB1

3.70e-0420422EFO_0010112
Diseaseblood zinc measurement

TRIM45 DLGAP2

4.91e-0423422EFO_0007584
Diseasealkaline phosphatase measurement

RNF10 TRIM8 ADAMTSL1 ADAMTS13 TRIB1 AXIN1 PLCE1

5.26e-041015427EFO_0004533
Diseasepresubiculum volume

ADAMTSL1 REV3L

8.96e-0431422EFO_0009400
Diseaserefractive error

ADAMTSL1 RGR NPLOC4 NPAT

1.18e-03326424MONDO_0004892
Diseaseage at onset, Myopia

ADAMTSL1 RGR NPLOC4

1.28e-03150423EFO_0004847, HP_0000545
Diseaselean body mass

RHOBTB1 TRIB1 AMZ1 PLCE1

2.04e-03379424EFO_0004995
DiseaseMyopia

DLGAP2 ADAMTSL1 RGR NPLOC4

2.16e-03385424HP_0000545
Diseaseomega-6:omega-3 polyunsaturated fatty acid ratio

MAU2 TRIB1

2.32e-0350422EFO_0010732
Diseaserefractive error, age at onset, Myopia

ADAMTSL1 RGR NPLOC4

2.62e-03193423EFO_0004847, HP_0000545, MONDO_0004892
Diseasebody fat distribution

ADAMTSL1 AMZ1 PLCE1

2.98e-03202423EFO_0004341
Diseaseresponse to paliperidone, schizophrenia symptom severity measurement

DLGAP2 ADAMTSL1 TRIB1

3.60e-03216423EFO_0007925, EFO_0007927
DiseaseIntellectual Disability

TRIM8 AASS RHOBTB2 BCKDK

3.69e-03447424C3714756
Diseasefatty acid measurement, linoleic acid measurement

MAU2 TRIB1

4.25e-0368422EFO_0005110, EFO_0006807

Protein segments in the cluster

PeptideGeneStartEntry
CPICLRKLQHVLGFR

AMZ1

296

Q400G9
EVHPPRVKQLLALCC

CCNO

191

P22674
HGDVLPRLQPLCVKC

ALS2

541

Q96Q42
GCPALPHKLVAICDI

AASS

341

Q9UDR5
VLPGILQKHCCILPD

DLGAP2

6

Q9P1A6
GFPVRCCIVVKHLGR

ACSS2

241

Q9NR19
CLPFIIGCNPTILHV

BCKDK

111

O14874
LSKLVPPECHCVREG

ATP2C1

131

P98194
DFCQHLPKPVTVRGC

ADAMTS13

1111

Q76LX8
CTPKCGPGFKHRIVL

ADAMTS6

971

Q9UKP5
ICHFRKPPVLQTTIC

CCNB3

296

Q8WWL7
PPKCELLHVAIVCAG

LARGE2

91

Q8N3Y3
SIVPAAKPCHRRVLC

NPAT

1051

Q14207
CHRPCKIEPVGIQRS

HDX

216

Q7Z353
RVRCHLGLKIPPGCE

ASPHD1

311

Q5U4P2
HCAGKVRPAVQPIAC

ADAMTSL1

1526

Q8N6G6
HICITCPEIKIKPLG

ECPAS

381

Q5VYK3
RHKPRICPSCGVNLA

HMGXB3

636

Q12766
RHGPLGKCVHCVPLE

NPLOC4

131

Q8TAT6
ITCHICLGKVRQPVI

OBI1

16

Q5W0B1
PLGKFRALCAVCAPV

LANCL3

146

Q6ZV70
CRRLLHKPVTLPCGL

LONRF2

146

Q1L5Z9
HKPVTLPCGLTVCKR

LONRF2

151

Q1L5Z9
GVVVCPILRHYVCPV

NANOS2

86

P60321
ILKVCQGCISPLPSH

NEK3

211

P51956
FCKTPELRTPCHLLV

RGR

41

P47804
CVRPACAPVLHVVPA

AXIN1

741

O15169
TERPFPCHICGKGFI

FIZ1

466

Q96SL8
PPKIRLCVHCLQAVF

MAU2

41

Q9Y6X3
IPCCPVHLKRLLIVV

SFTPC

26

P11686
YRCGPLIDLCKGPHV

TARS3

331

A2RTX5
FKAPRLLPCLHTVCT

TRIM45

36

Q9H8W5
SVCHGVLKRPARLPC

RNF151

21

Q2KHN1
VLKRPARLPCSHIFC

RNF151

26

Q2KHN1
HIPGCKVVPFCGVFL

PLCE1

696

Q9P212
IKHFCPRAPVILVGC

RHOBTB2

126

Q9BYZ6
IKHFCPRTPVILVGC

RHOBTB1

126

O94844
CKCGFAGLPRPTHKI

ACTL7A

81

Q9Y615
EIRCHCPKAPIILVG

RHOU

146

Q7L0Q8
FEKPVTCPRLCLVIG

EEFSEC

416

P57772
FCIPEHISPKARCLI

TRIB1

301

Q96RU8
HIPCVSLNCPVLFKL

REV3L

3096

O60673
PAKAKDVCVVRLCPH

SPOCD1

921

Q6ZMY3
PPTAAKITRCGHIFC

RNF10

231

Q8N5U6
VSLGCPVPKAELICH

ZNF264

51

O43296
HCVFCRRGPPLPAQK

TRIM8

91

Q9BZR9