Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	telomere maintenance via recombination	SMC6 SMC5 RAD50	7.98e-06	15	55	3	GO:0000722
GeneOntologyBiologicalProcess	mitotic recombination	SMC6 SMC5 RAD50	5.01e-05	27	55	3	GO:0006312
GeneOntologyCellularComponent	interchromatin granule	SMC6 SMC5	7.01e-05	5	56	2	GO:0035061
GeneOntologyCellularComponent	sex chromosome	SIN3B SMC6 SMC5	2.23e-04	44	56	3	GO:0000803
GeneOntologyCellularComponent	Smc5-Smc6 complex	SMC6 SMC5	2.51e-04	9	56	2	GO:0030915
GeneOntologyCellularComponent	U2-type prespliceosome	LUC7L LUC7L2	1.05e-03	18	56	2	GO:0071004
GeneOntologyCellularComponent	prespliceosome	LUC7L LUC7L2	1.05e-03	18	56	2	GO:0071010
Domain	RecF/RecN/SMC_N	SMC6 SMC5 RAD50	1.34e-06	8	55	3	IPR003395
Domain	SMC_N	SMC6 SMC5 RAD50	1.34e-06	8	55	3	PF02463
Domain	Smc5/Smc6	SMC6 SMC5	8.51e-06	2	55	2	IPR033268
Domain	LUC7	LUC7L LUC7L2	2.55e-05	3	55	2	PF03194
Domain	Luc7-rel	LUC7L LUC7L2	2.55e-05	3	55	2	IPR004882
Domain	CH	LMO7 SYNE2 NAV2 ARHGEF6	3.99e-05	65	55	4	SM00033
Domain	CH	LMO7 SYNE2 NAV2 ARHGEF6	5.34e-05	70	55	4	PF00307
Domain	-	LMO7 SYNE2 NAV2 ARHGEF6	5.65e-05	71	55	4	1.10.418.10
Domain	CH	LMO7 SYNE2 NAV2 ARHGEF6	6.30e-05	73	55	4	PS50021
Domain	CH-domain	LMO7 SYNE2 NAV2 ARHGEF6	7.00e-05	75	55	4	IPR001715
Domain	Spectrin_repeat	DSP SYNE2 PPL	8.36e-05	29	55	3	IPR002017
Domain	Spectrin/alpha-actinin	DSP SYNE2 PPL	1.13e-04	32	55	3	IPR018159
Domain	SPEC	DSP SYNE2 PPL	1.13e-04	32	55	3	SM00150
Domain	Plectin_repeat	DSP PPL	1.77e-04	7	55	2	IPR001101
Domain	Plectin	DSP PPL	1.77e-04	7	55	2	PF00681
Domain	PLEC	DSP PPL	1.77e-04	7	55	2	SM00250
Domain	SH3	CASKIN2 NGEF PACSIN3 MAP3K21 ARHGEF6	4.29e-04	216	55	5	PS50002
Domain	SH3	CASKIN2 NGEF PACSIN3 MAP3K21 ARHGEF6	4.29e-04	216	55	5	SM00326
Domain	SM22_calponin	LMO7 ARHGEF6	4.60e-04	11	55	2	IPR003096
Domain	SH3_domain	CASKIN2 NGEF PACSIN3 MAP3K21 ARHGEF6	4.67e-04	220	55	5	IPR001452
Domain	GrpE_coiled_coil	CCDC186 PACSIN3	5.51e-04	12	55	2	IPR013805
Domain	SH3_1	NGEF PACSIN3 MAP3K21 ARHGEF6	1.38e-03	164	55	4	PF00018
Domain	SH3_9	PACSIN3 MAP3K21 ARHGEF6	1.57e-03	78	55	3	PF14604
Domain	G_patch	SUGP2 AGGF1	2.07e-03	23	55	2	SM00443
Domain	G_patch_dom	SUGP2 AGGF1	2.07e-03	23	55	2	IPR000467
Domain	G-patch	SUGP2 AGGF1	2.07e-03	23	55	2	PF01585
Domain	G_PATCH	SUGP2 AGGF1	2.07e-03	23	55	2	PS50174
Domain	tRNA-bd_arm	DSP CCDC186	2.25e-03	24	55	2	IPR010978
Domain	HR1_rho-bd	PPFIA1 CFAP58	2.45e-03	25	55	2	IPR011072
Domain	GDS_CDC24_CS	NGEF ARHGEF6	5.88e-03	39	55	2	IPR001331
Domain	t-SNARE	CCDC186 DAAM2	7.12e-03	43	55	2	IPR010989
Domain	TBC	TBC1D14 TBC1D25	9.16e-03	49	55	2	SM00164
Domain	RabGAP-TBC	TBC1D14 TBC1D25	1.07e-02	53	55	2	PF00566
Domain	TBC_RABGAP	TBC1D14 TBC1D25	1.14e-02	55	55	2	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D14 TBC1D25	1.14e-02	55	55	2	IPR000195
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	LUC7L HOOK1 LMO7 DSP CASKIN2 PPFIA1 SYNE2 NAV2 MAP3K21 SRRM2	1.04e-06	861	56	10	36931259
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	HOOK1 MYH7B CARD11 MORC2 PPL RAD50	1.08e-06	208	56	6	33230847
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	CHCHD3 SUGP2 DSP MORC2 SRRM2 PPL	1.14e-06	210	56	6	16565220
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	STK10 HOOK1 LMO7 CYP19A1 NAV2 MORC2 SRRM2 ARHGEF6	1.40e-06	503	56	8	16964243
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CCDC27 CHCHD3 HOOK1 SMIM12 LMO7 DSP MYH7B PPFIA1 SYNE2 NAV2 MAP7D2 PPL	2.53e-06	1442	56	12	35575683
Pubmed	Human Smc5/6 recognises transcription-generated positive DNA supercoils.	SMC6 SMC5	2.55e-06	2	56	2	39242537
Pubmed	SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability.	SMC6 SMC5	2.55e-06	2	56	2	31867888
Pubmed	Desmoplakin and periplakin genetically and functionally contribute to eosinophilic esophagitis.	DSP PPL	2.55e-06	2	56	2	34815391
Pubmed	Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells.	SMC6 SMC5	2.55e-06	2	56	2	24258023
Pubmed	Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor.	SMC6 SMC5	2.55e-06	2	56	2	26983541
Pubmed	The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection.	SMC6 SMC5	2.55e-06	2	56	2	28095508
Pubmed	Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex.	SMC6 SMC5	2.55e-06	2	56	2	15601840
Pubmed	Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex.	SMC6 SMC5	2.55e-06	2	56	2	11408570
Pubmed	Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase.	SMC6 SMC5	2.55e-06	2	56	2	32320646
Pubmed	Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency.	SMC6 SMC5	2.55e-06	2	56	2	36376394
Pubmed	The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr.	SMC6 SMC5	2.55e-06	2	56	2	33811831
Pubmed	The maintenance of chromosome structure: positioning and functioning of SMC complexes.	SMC6 SMC5	2.55e-06	2	56	2	25145851
Pubmed	The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine.	SMC6 SMC5	2.55e-06	2	56	2	33301731
Pubmed	Depletion of SMC5/6 sensitizes male germ cells to DNA damage.	SMC6 SMC5	2.55e-06	2	56	2	30281394
Pubmed	Specialized interfaces of Smc5/6 control hinge stability and DNA association.	SMC6 SMC5	2.55e-06	2	56	2	28134253
Pubmed	The SMC5/6 complex: folding chromosomes back into shape when genomes take a break.	SMC6 SMC5	2.55e-06	2	56	2	38375830
Pubmed	Telomeric DNA mediates de novo PML body formation.	SMC6 SMC5	2.55e-06	2	56	2	19793919
Pubmed	The SMC5/6 Complex Interacts with the Papillomavirus E2 Protein and Influences Maintenance of Viral Episomal DNA.	SMC6 SMC5	2.55e-06	2	56	2	29848583
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	HDAC5 LMO7 CASKIN2 CCDC186 PPFIA1 SYNE2	3.19e-06	251	56	6	29778605
Pubmed	Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.	ANKRD44 COG2 HOOK1 LUC7L2 PPFIA1 PACSIN3 AGGF1 AKIRIN2 ODF1 CCDC102B RAB3IL1 AFAP1L1	3.24e-06	1477	56	12	31515488
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	STK10 SUGP2 LMO7 DSP MORC2 SRRM2 ARHGEF6 PPL RAD50	3.80e-06	774	56	9	15302935
Pubmed	The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability.	SMC6 SMC5	7.63e-06	3	56	2	21550342
Pubmed	Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms.	LUC7L LUC7L2	7.63e-06	3	56	2	33852859
Pubmed	Targeted resequencing reveals genetic risks in patients with sporadic idiopathic pulmonary fibrosis.	DSP LAMA3	7.63e-06	3	56	2	29920840
Pubmed	Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication.	SMC6 SMC5	7.63e-06	3	56	2	27626656
Pubmed	The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress.	SMC6 SMC5	7.63e-06	3	56	2	38886582
Pubmed	Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin.	DSP PPL	7.63e-06	3	56	2	9412476
Pubmed	Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress.	SMC6 SMC5	7.63e-06	3	56	2	27792189
Pubmed	Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability.	SMC6 SMC5	7.63e-06	3	56	2	18667531
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	PPP1R21 CHCHD3 LUC7L2 CCDC186 SYNE2 TBC1D14 NGEF CARD11 SMC5 ARHGEF6	1.10e-05	1124	56	10	21900206
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	SIN3B HDAC5 DSP NGEF PACSIN3 MORC2 SMC5	1.10e-05	475	56	7	31040226
Pubmed	Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.	LUC7L2 MORC2 SRRM2 RAD50	1.11e-05	85	56	4	16051665
Pubmed	Coordinated regulation of scaffold opening and enzymatic activity during CARD11 signaling.	RNF31 CARD11	1.52e-05	4	56	2	31391255
Pubmed	DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links.	SMC6 SMC5	2.54e-05	5	56	2	25931565
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	PPP1R21 CHCHD3 DSP CCDC186 SYNE2 SMC6 MORC2 RAD50	2.67e-05	754	56	8	35906200
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	FREM2 SUGP2 LMO7 DSP PPFIA1 NAV2 AGGF1	2.89e-05	552	56	7	10737800
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	HDAC5 LMO7 SYNE2 NAV2 SMC5	3.16e-05	225	56	5	12168954
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	STK10 CHCHD3 CASKIN2 PPFIA1 PACSIN3 DAAM2	3.20e-05	377	56	6	38117590
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	STK10 CHCHD3 CASKIN2 PPFIA1 PACSIN3 NAV2 PPP1R37	3.50e-05	569	56	7	30639242
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	LUC7L CHCHD3 SUGP2 LMO7 DSP SYNE2 PACSIN3 SRRM2 RAD50	3.51e-05	1024	56	9	24711643
Pubmed	Human MMS21/NSE2 is a SUMO ligase required for DNA repair.	SMC6 SMC5	3.80e-05	6	56	2	16055714
Pubmed	PJA1 Coordinates with the SMC5/6 Complex To Restrict DNA Viruses and Episomal Genes in an Interferon-Independent Manner.	SMC6 SMC5	3.80e-05	6	56	2	30185588
Pubmed	Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin.	DSP PPL	3.80e-05	6	56	2	12366696
Pubmed	Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling.	RNF31 CARD11	3.80e-05	6	56	2	27777308
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DSP PPFIA1 NGEF SRRM2 RAD50	3.82e-05	234	56	5	36243803
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	LUC7L LMO7 DSP LUC7L2 PPFIA1 SRRM2 RAD50	4.04e-05	582	56	7	20467437
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	CHCHD3 HDAC5 HOOK1 LMO7 SMC6 TBC1D25 MAP3K21 RAB3IL1 ARHGEF6 RAD50	4.38e-05	1321	56	10	27173435
Pubmed	Exons 5-15 of kazrin are dispensable for murine epidermal morphogenesis and homeostasis.	DSP PPL	5.32e-05	7	56	2	22513779
Pubmed	Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex.	SMC6 SMC5	5.32e-05	7	56	2	18086888
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SIN3B HDAC5 DSP LUC7L2 PPFIA1 RAD50	5.68e-05	418	56	6	34709266
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	LMO7 LUC7L2 PPFIA1 SRRM2 ARHGEF6	5.74e-05	255	56	5	15324660
Pubmed	Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain.	CYP19A1 LAMA3	7.09e-05	8	56	2	9852162
Pubmed	Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-Mediated NF-κB Activation Pathway.	RNF31 CARD11	7.09e-05	8	56	2	33329596
Pubmed	Plakin proteins are coordinately cleaved during apoptosis but preferentially through the action of different caspases.	DSP PPL	9.10e-05	9	56	2	15500642
Pubmed	Molecular Insights into the Architecture of the Human SMC5/6 Complex.	SMC6 SMC5	9.10e-05	9	56	2	32389690
Pubmed	Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks.	SMC6 SMC5	9.10e-05	9	56	2	16810316
Pubmed	Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.	DSP LAMA3	9.10e-05	9	56	2	12482924
Pubmed	Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.	SYNE2 DAAM2 CARD11	9.78e-05	55	56	3	18570454
Pubmed	The functional interactome landscape of the human histone deacetylase family.	SIN3B CHCHD3 HDAC5 SYNE2 SRRM2	1.03e-04	289	56	5	23752268
Pubmed	Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.	SMC6 SMC5	1.14e-04	10	56	2	22751501
Pubmed	Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression.	SMC6 SMC5	1.39e-04	11	56	2	26919979
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	LMO7 LUC7L2 PPFIA1 NAV2 MORC2 SMC5	1.47e-04	497	56	6	36774506
Pubmed	FAM188B enhances cell survival via interaction with USP7.	DSP SRRM2 RAD50	1.61e-04	65	56	3	29795372
Pubmed	SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.	SMC6 SMC5	1.66e-04	12	56	2	28302748
Pubmed	Timeless links replication termination to mitotic kinase activation.	SMC6 SMC5	1.96e-04	13	56	2	21573113
Pubmed	Cytosolic Iron-Sulfur Assembly Is Evolutionarily Tuned by a Cancer-Amplified Ubiquitin Ligase.	SMC6 SMC5	1.96e-04	13	56	2	29225034
Pubmed	The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins.	SMC6 SMC5	1.96e-04	13	56	2	17589526
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	LUC7L HOOK1 DSP LUC7L2 PACSIN3 MAP3K21 SRRM2 AFAP1L1 RAD50	1.97e-04	1284	56	9	17353931
Pubmed	A molecular dissection of the repression circuitry of Ikaros.	SIN3B HDAC5	2.29e-04	14	56	2	12015313
Pubmed	Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.	SIN3B NGEF RAD50	2.66e-04	77	56	3	19505873
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	LUC7L LMO7 CARD11 MAP3K21 SRRM2	2.90e-04	361	56	5	26167880
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	SYNE2 CFAP58 SRRM2 RAD50	2.91e-04	197	56	4	20811636
Pubmed	Docking motif-guided mapping of the interactome of protein phosphatase-1.	PPP1R21 CHCHD3 PPP1R37	2.98e-04	80	56	3	19389623
Pubmed	SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis.	SMC6 SMC5	3.01e-04	16	56	2	33200984
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	FREM2 LAMA3	3.01e-04	16	56	2	16880404
Pubmed	Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.	NGEF ARHGEF6	3.83e-04	18	56	2	12799088
Pubmed	Scrib:Rac1 interactions are required for the morphogenesis of the ventricular myocardium.	DSP ARHGEF6	3.83e-04	18	56	2	25139745
Pubmed	Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier.	DSP PPL	4.28e-04	19	56	2	18166659
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	SIN3B HDAC5 SUGP2 DSP AGGF1 MORC2 RAD50	4.37e-04	857	56	7	25609649
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	LUC7L LMO7 SYNE2	4.49e-04	92	56	3	15840729
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	HDAC5 SUGP2 DAAM2 SMC5 SRRM2	5.01e-04	407	56	5	12693553
Pubmed	PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.	FREM2 LAMA3	5.24e-04	21	56	2	27856617
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	CHCHD3 LMO7 DSP SRRM2 PPL RAD50	6.22e-04	652	56	6	31180492
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SUGP2 DAAM2 SRRM2	6.42e-04	104	56	3	9205841
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	HDAC5 SMC5 PPL	6.60e-04	105	56	3	9628581
Pubmed	Regulation of mesenchymal-to-epithelial transition by PARAXIS during somitogenesis.	DAAM2 ARHGEF6	6.87e-04	24	56	2	24038871
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	ANKRD44 LUC7L CHCHD3 LUC7L2 AGGF1 SRRM2	7.16e-04	670	56	6	22990118
Pubmed	NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.	LMO7 DSP	7.46e-04	25	56	2	30309841
Pubmed	Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome.	PACSIN3 ARHGEF6	7.46e-04	25	56	2	16374509
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	ANKRD44 HDAC5 LMO7 PPFIA1 MAP3K21	7.57e-04	446	56	5	24255178
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	STK10 CASKIN2 CCDC186 PACSIN3 AGGF1 AFAP1L1	8.28e-04	689	56	6	36543142
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CHCHD3 LMO7 DSP PACSIN3 LAMA3 PPL AFAP1L1 RAD50	8.66e-04	1257	56	8	36526897
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SIN3B HOOK1 PPFIA1 SYNE2 NGEF JAKMIP3 RAD50	8.69e-04	963	56	7	28671696
Pubmed	Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.	NAV2 MORC2	8.71e-04	27	56	2	19026994
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	FREM2 LAMA3	1.01e-03	29	56	2	22613833
Interaction	YWHAG interactions	LUC7L HDAC5 RNF31 LMO7 DSP CASKIN2 LUC7L2 PPFIA1 SYNE2 NAV2 MAP3K21 SRRM2 ARHGEF6 AFAP1L1	5.65e-06	1248	56	14	int:YWHAG
Interaction	RAB3IP interactions	CHCHD3 LMO7 TBC1D25 RAB3IL1 PPL	1.68e-05	115	56	5	int:RAB3IP
Interaction	KIF20A interactions	CHCHD3 SUGP2 LMO7 DSP SYNE2 PACSIN3 NAV2 MAP7D2 MORC2 SRRM2 PPL TRIM7	2.54e-05	1052	56	12	int:KIF20A
Interaction	HDAC4 interactions	SIN3B CHCHD3 HDAC5 LMO7 LUC7L2 NGEF PACSIN3 MORC2 SMC5 MAP3K21	3.38e-05	744	56	10	int:HDAC4
Interaction	YWHAH interactions	HDAC5 HOOK1 LMO7 DSP CASKIN2 PPFIA1 SYNE2 NAV2 TBC1D25 MAP3K21 SRRM2 ARHGEF6	4.01e-05	1102	56	12	int:YWHAH
Interaction	HERC2 interactions	LUC7L HOOK1 LUC7L2 CCDC186 PPFIA1 SYNE2 MAP7D2 PPL	7.06e-05	503	56	8	int:HERC2
GeneFamily	Structural maintenance of chromosomes proteins\|SMC5-6 protein complex	SMC6 SMC5	4.82e-05	6	33	2	1034
GeneFamily	Structural maintenance of chromosomes proteins\|Cohesin complex	SMC6 SMC5	6.75e-05	7	33	2	761
GeneFamily	EF-hand domain containing\|Plakins	DSP PPL	8.98e-05	8	33	2	939
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	SUGP2 AGGF1	7.29e-04	22	33	2	579
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PPP1R21 CHCHD3 PPP1R37	4.32e-03	181	33	3	694
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	NGEF ARHGEF6	6.44e-03	66	33	2	722
GeneFamily	Sterile alpha motif domain containing	CASKIN2 PPFIA1	1.12e-02	88	33	2	760
GeneFamily	PDZ domain containing	LMO7 CARD11	3.13e-02	152	33	2	1220
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 MAP3K21 PPL	3.88e-09	188	56	7	0d86044bc340e3efb90d0022dd299873639d831c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 MAP3K21 PPL	4.17e-09	190	56	7	c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCell	PCW_13-14-Epithelial-Epithelial_airway\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 MAP3K21 PPL	4.82e-09	194	56	7	7b2b40a56eb9c7203ca50133b2da4fd8fdd4a5cf
ToppCell	PCW_07-8.5-Epithelial\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 MAP3K21 PPL	4.82e-09	194	56	7	f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 MAP3K21 PPL	5.00e-09	195	56	7	d67a2b489c29bfd575751c13d2a5b1efdec5240a
ToppCell	PCW_10-12-Epithelial\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 MAP3K21 PPL	5.18e-09	196	56	7	9bfb31ff3e4f2c0a9405c418c86bfec5dbca23e2
ToppCell	PCW_13-14-Epithelial\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 MAP3K21 PPL	5.55e-09	198	56	7	48eb6f69a464a34ab32e8d425a22b9d45ec20428
ToppCell	wk_15-18-Epithelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 MAP3K21 PPL	5.55e-09	198	56	7	12bbe77c3d68bf1e545949dbb1eb49ed3641de3d
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	FREM2 HOOK1 LMO7 DSP NAV2 LAMA3 MAP3K21	5.95e-09	200	56	7	eac33be484dc443794e66e473f03e98406c2983e
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP MAP3K21 PPL	1.14e-07	183	56	6	c5b10571599dc26476170b54b53f09c23e6b3117
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating1_(8)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 MAP3K21	1.30e-07	187	56	6	c2940aec30b3c2c113f6a65126dc6f1969cf301e
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LMO7 DSP SYNE2 NAV2 LAMA3 PPL	1.30e-07	187	56	6	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 MAP3K21	1.34e-07	188	56	6	beb2df2332a46cc81b10e8e29fc9829020111f03
ToppCell	11.5-Airway-Epithelial-Bud_tip_adjacent\|Airway / Age, Tissue, Lineage and Cell class	FREM2 HOOK1 LMO7 DSP LAMA3 PPL	1.52e-07	192	56	6	fbb34a959b9bd9cb72a5195a07f4653a957e4ca8
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21 PPL	1.52e-07	192	56	6	b73f24d1c55dfef1eb01c26da117dbf637ea080a
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 PPL	1.52e-07	192	56	6	450baeb5c3df7a9445472530002ce38f177a333c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 MAP3K21	1.52e-07	192	56	6	1aa5e4d9b32013a3f272561dcb8377f6805706df
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating1_(8)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 MAP3K21	1.57e-07	193	56	6	979980369d2dbee9dc4770d72b93037abd7786eb
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21 PPL	1.61e-07	194	56	6	c011cd59bb4ca4134331cba0f5d73bdbd7011d64
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 PPL	1.66e-07	195	56	6	d673f8844896d5c7b76a7bc7f6b88a039f1bc263
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 MAP3K21	1.66e-07	195	56	6	ce1ba5911e8a6ddb07434acc37147c38e94245ff
ToppCell	wk_20-22-Epithelial-Distal_epithelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FREM2 LMO7 DSP LAMA3 MAP3K21 PPL	1.71e-07	196	56	6	cd507ee2baf4f52d6498811b3510d3164b56311f
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21 PPL	1.71e-07	196	56	6	7b17d47b7758d8ccf9dbefd097aeb553791a1eed
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	LMO7 DSP SYNE2 NAV2 LAMA3 MAP7D2	1.77e-07	197	56	6	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	wk_15-18-Epithelial-Distal_epithelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FREM2 LMO7 DSP LAMA3 MAP3K21 PPL	1.77e-07	197	56	6	b7aff83c27606d87565382a768119a863fe1c294
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	LMO7 DSP SYNE2 NAV2 LAMA3 PPL	1.82e-07	198	56	6	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-stalk_late\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 PPL	1.82e-07	198	56	6	1851b7f4198b42c21c934e2fbda39dbd65e2625c
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 PPL	1.82e-07	198	56	6	c477405b093f4e5374e57bcacf1fb204a0f7eb3b
ToppCell	PCW_10-12-Epithelial-Epithelial_airway\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 PPL	1.82e-07	198	56	6	9a12e5e47236433e512c668005fe3f8be6fde95c
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	LMO7 DSP SYNE2 NAV2 LAMA3 PPL	1.88e-07	199	56	6	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-stalk_intermediate\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 PPL	1.88e-07	199	56	6	debdd7dba774d9ccff7effc3f4c132393d203dfa
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 PPL	1.88e-07	199	56	6	af664e0d41a889a75dbf6cf0d50acd26f5ab3a3a
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	HOOK1 DSP PACSIN3 LAMA3 PPL TRIM7	1.93e-07	200	56	6	afac850d5a40de0d6f02857cf81a19443d90b1eb
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	LMO7 DSP SYNE2 NAV2 LAMA3 PPL	1.93e-07	200	56	6	8683445ad5b70748c4a1f12eb77d47623085147e
ToppCell	wk_08-11-Epithelial\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3 PPL	1.93e-07	200	56	6	445fc7995ffc440c6256a6aab0bbf33fb0fea028
ToppCell	wk_15-18-Epithelial-Distal_epithelial-type_I_pneumocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FREM2 LMO7 DSP LAMA3 PPL	2.66e-06	174	56	5	2cd6638b361ca05ab83d09ce657194aed97873b7
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LMO7 DSP NAV2 LAMA3 DAAM2	2.89e-06	177	56	5	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LMO7 DSP NAV2 LAMA3 PPL	3.05e-06	179	56	5	04ce3673e46606f63d9c87bcba3a64c96817d812
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LMO7 DSP NAV2 LAMA3 PPL	3.22e-06	181	56	5	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LMO7 DSP NAV2 LAMA3 PPL	3.40e-06	183	56	5	ff6dde877659cde9daa3263db0932c9c9ef1adac
ToppCell	Control-Epithelial_alveolar-AT_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FREM2 LMO7 DSP NAV2 LAMA3	3.49e-06	184	56	5	51e129b3fcc2df083eda05a3afe3717218b1e52b
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LMO7 DSP NAV2 LAMA3 PPL	3.49e-06	184	56	5	7cc5796557379c3d1db078c1aeda40659c6e401c
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HOOK1 LMO7 NAV2 LAMA3 PPL	3.49e-06	184	56	5	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 LAMA3 MAP3K21	3.49e-06	184	56	5	fa4915b0498f3069fd5ef497286445528f75187e
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LMO7 DSP NAV2 LAMA3 PPL	3.68e-06	186	56	5	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	3.68e-06	186	56	5	bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCell	LPS-antiTNF-Epithelial_alveolar\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HOOK1 LMO7 DSP NAV2 LAMA3	3.78e-06	187	56	5	201ff693e4756ee3e44762885b3a303a77eb535b
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 LAMA3 MAP3K21	3.78e-06	187	56	5	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HOOK1 LMO7 DSP NAV2 LAMA3	3.88e-06	188	56	5	43a0508d2524a5b310e89e9422843dcaab999bc3
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HOOK1 LMO7 NAV2 LAMA3 MAP3K21	3.88e-06	188	56	5	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	3.98e-06	189	56	5	5d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP LAMA3	3.98e-06	189	56	5	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	IPF-Epithelial-Basal\|IPF / Disease state, Lineage and Cell class	HOOK1 LMO7 DSP LAMA3 PPL	4.09e-06	190	56	5	ea19e9ce954f2dfde97388db9695325cd92ab88f
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 LAMA3 MAP3K21	4.09e-06	190	56	5	625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOOK1 DSP CCDC186 SYNE2 SMC5	4.19e-06	191	56	5	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	4.19e-06	191	56	5	63aa671837b79d2feb7ed1e67712cc01caf72bef
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOOK1 DSP CCDC186 SYNE2 SMC5	4.19e-06	191	56	5	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	4.30e-06	192	56	5	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 PPL	4.30e-06	192	56	5	39804d9ddc67c1b41887752df2503389eae44a1a
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	4.30e-06	192	56	5	b7c01e12b3e9be960a741b08835f1dfff65d0d47
ToppCell	IPF-Epithelial-Basal\|World / Disease state, Lineage and Cell class	HOOK1 LMO7 DSP LAMA3 PPL	4.30e-06	192	56	5	9b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating1_(8)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	4.30e-06	192	56	5	8898332387e5d746feb346ce1dabd6b2218fc6e5
ToppCell	PCW_05-06-Epithelial-Epithelial_proliferating\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 LAMA3 MAP3K21	4.41e-06	193	56	5	5f0eba7b1440beb891d94a288f7f18a4e13c3a88
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	4.41e-06	193	56	5	ab78fb1603ea6f720ba2d30148fe65dccf271fe1
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	4.41e-06	193	56	5	4b8202fcfe639a73f69a13f48fc3601ade256346
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	4.52e-06	194	56	5	c197e4acbff42a9f0410b6801c2bfcf6160aefc1
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 LMO7 DSP PPL	4.52e-06	194	56	5	f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	4.52e-06	194	56	5	c47fc3f716ab091a39c20d7639ac783029589ee5
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	4.64e-06	195	56	5	f08e41706680881ebd0afcd08a02f8ac0089f04e
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	4.64e-06	195	56	5	62d369a8af2b76a2553bc8ff9cb89a133b060123
ToppCell	15-Airway-Epithelial\|Airway / Age, Tissue, Lineage and Cell class	FREM2 HOOK1 LMO7 DSP PPL	4.64e-06	195	56	5	cd0af7e260e4f0c5a9ecdfa93619f37b2a9308a5
ToppCell	wk_15-18-Epithelial-Distal_epithelial-type_II_pneumocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FREM2 LMO7 LAMA3 MAP3K21 PPL	4.64e-06	195	56	5	0e3aac1b1a1fd483f5fb9a394eb90c0e1ce63542
ToppCell	wk_20-22-Epithelial-Distal_epithelial-type_I_pneumocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FREM2 LMO7 DSP LAMA3 PPL	4.75e-06	196	56	5	e24a7aaf41793abba66c1189d933ca05b14c1af9
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	4.75e-06	196	56	5	0a34a0009f479384f1994c6f977f942699a132c8
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	4.87e-06	197	56	5	22b26bac3a99b20c73bfa6e6f81026d064eaa9e8
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	HOOK1 LMO7 DSP NAV2 LAMA3	4.87e-06	197	56	5	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	LMO7 DSP SYNE2 LAMA3 MAP3K21	4.87e-06	197	56	5	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	4.87e-06	197	56	5	6852a8ec1397811bbdd1fc625c52ed4fa75a931e
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DSP PACSIN3 LAMA3 MND1 TRIM7	4.87e-06	197	56	5	2430f31d9312338e0ca23bfc6bdb0365340860fd
ToppCell	15-Distal-Epithelial\|Distal / Age, Tissue, Lineage and Cell class	FREM2 HOOK1 LMO7 DSP PPL	4.87e-06	197	56	5	9fbd1abf050b364155a67962a9731118304f72fb
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FREM2 HOOK1 DSP LAMA3 MAP3K21	4.87e-06	197	56	5	2f91b3870a7058168093a143110954c07588cfe9
ToppCell	11.5-Airway-Epithelial\|Airway / Age, Tissue, Lineage and Cell class	FREM2 HOOK1 LMO7 DSP PPL	4.87e-06	197	56	5	e671af1b69566d97afe97f1a959a07b6f4c05620
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	HOOK1 LMO7 DSP NAV2 LAMA3	5.00e-06	198	56	5	50852713c017217c79777c95857097103bcf2fbe
ToppCell	15-Distal-Epithelial-Bud_tip_adjacent\|Distal / Age, Tissue, Lineage and Cell class	FREM2 LMO7 DSP LAMA3 PPL	5.00e-06	198	56	5	f4d9d5995a42f71bf412f0ad299fc963bad3a898
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	HOOK1 LMO7 DSP NAV2 LAMA3	5.00e-06	198	56	5	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	LMO7 DSP SYNE2 NAV2 LAMA3	5.00e-06	198	56	5	b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCell	LPS_anti-TNF-Epithelial_alveolar\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	HOOK1 LMO7 DSP NAV2 LAMA3	5.00e-06	198	56	5	53e9ed1b19cb26be58da0f37057caca0cdfaabeb
ToppCell	Control_saline-Epithelial_alveolar-AT_1\|Control_saline / Treatment groups by lineage, cell group, cell type	LMO7 DSP SYNE2 NAV2 LAMA3	5.00e-06	198	56	5	9b161285df7a4e51618f3517cfc5b8221ba55786
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / Treatment groups by lineage, cell group, cell type	HOOK1 LMO7 DSP SYNE2 LAMA3	5.00e-06	198	56	5	655df75b9692d815c7f6910275e1f684ac63bf62
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DSP PACSIN3 LAMA3 PPL TRIM7	5.00e-06	198	56	5	22935a8afac54021f68b5f7a5accf51523e2f336
ToppCell	LPS_IL1RA-Epithelial_alveolar\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	HOOK1 LMO7 DSP NAV2 LAMA3	5.12e-06	199	56	5	5b140ac88ebc25ce397ae577e48f3e271faf46e7
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	LMO7 DSP SYNE2 NAV2 LAMA3	5.12e-06	199	56	5	1c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	LMO7 DSP SYNE2 NAV2 LAMA3	5.12e-06	199	56	5	a270630626df614f8605abddb7dee7c4d74f6149
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	LMO7 CCDC186 SYNE2 SMC6 RAD50	5.12e-06	199	56	5	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	(01)_IL1RL1+-(2)_GFP_FOXI1\|(01)_IL1RL1+ / shred by cell type by condition	LMO7 CCDC186 SYNE2 SMC6 RAD50	5.12e-06	199	56	5	a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	HOOK1 LMO7 DSP NAV2 LAMA3	5.25e-06	200	56	5	c89f3cb36bb14c476d6a392bfd3ded1c8feecfeb
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	LMO7 DSP SYNE2 NAV2 LAMA3	5.25e-06	200	56	5	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	LMO7 DSP SYNE2 NAV2 LAMA3	5.25e-06	200	56	5	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_basal-Basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	HOOK1 DSP PACSIN3 LAMA3 PPL	5.25e-06	200	56	5	0594ca7bc313b73e1dc800cf058f8f798b0284cb
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-Tfh\|Lung / Manually curated celltypes from each tissue	TRIB2 HOOK1 SYNE2 MND1	3.08e-05	142	56	4	319812c84fad93276bf093f2ad78db02ae745bf4
Computational	Thymus genes.	TRIB2 DSP LAMA3 ODF1 SRRM2 ARHGEF6 PPL	3.80e-05	325	32	7	MODULE_44
Computational	Genes in the cancer module 119.	TRIB2 RNF31 CCDC186 SYNE2	8.09e-04	143	32	4	MODULE_119
Computational	Immune (humoral) and inflammatory response.	TRIB2 LAMA3 ODF1 SRRM2 RAB3IL1 ARHGEF6 PPL	9.30e-04	546	32	7	MODULE_84
Computational	Genes in the cancer module 525.	ANKRD44 STK10 SYNE2	9.66e-04	66	32	3	MODULE_525
Disease	Dental enamel hypoplasia	MYH7B MAP3K21	2.31e-04	12	56	2	EFO_1001304
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	HOOK1 SYNE2	2.31e-04	12	56	2	DOID:11726 (implicated_via_orthology)
Disease	venous thromboembolism	PACSIN3 NAV2 CCDC102B MAP3K21 SRRM2 RAD50	2.33e-04	460	56	6	EFO_0004286
Disease	Osteoporosis	HDAC5 CYP19A1 DAAM2	2.37e-04	63	56	3	C0029456
Disease	beta-amyloid 1-42 measurement	CYP19A1 PPP1R37 CARD11	6.13e-04	87	56	3	EFO_0004670
Disease	eicosapentaenoic acid measurement	NAV2 RAB3IL1	1.59e-03	31	56	2	EFO_0007760

Protein segments in the cluster

Peptide	Gene	Start	Entry
DELRTLRTKVKCLED	CCDC186	496	Q7Z3E2
LRTKVKCLEDERLRT	CCDC186	501	Q7Z3E2
KQCLEEELKSRRDLE	ARHGEF6	736	Q15052
ICERLLKEREEKVRE	AKIRIN2	151	Q53H80
KLERELRSCKRQVRE	AGGF1	31	Q8N302
ERKLTKRDCVISELD	CCDC27	516	Q2M243
KLKDEECERLSKVRE	RAB3IL1	91	Q8TBN0
REKERKLVDCHRELE	RAD50	316	Q92878
RLERKERECETKTLE	DAAM2	461	Q86T65
ECDRRTELAKKRLAE	LUC7L	96	Q9NQ29
TEVEPCRRRKEESDK	LAMA3	2586	Q16787
RLAKERREEREKCLA	MAP7D2	56	Q96T17
LKERTRCRALEEELE	CFAP58	691	Q5T655
RFDKDEREKLCRIVI	FREM2	1951	Q5SZK8
KCKRERELQQSLERE	DCLK3	141	Q9C098
AARRRKLEDECTELK	MYH7B	986	A7E2Y1
KIGRCETEERTRLAK	MND1	111	Q9BWT6
LREEIVDKTRLIERC	PPL	1251	O60437
EITRIKKECEREIRR	JAKMIP3	196	Q5VZ66
RDRVCSKKDIILRTE	LMO7	51	Q8WWI1
REEVRDDKTTIKCET	PPFIA1	726	Q13136
ERARELKEKEATLCL	ANKRD44	501	Q8N8A2
LEKEAKECRLRTEEC	PPP1R21	186	Q6ZMI0
CLLDSVRRDIKKVDR	ODF1	6	Q14990
KKVDRELRQLRCIDE	ODF1	16	Q14990
ESDTVKRRPKCRERE	CASKIN2	986	Q8WXE0
ILRERICSEEERAKA	CHCHD3	106	Q9NX63
EEVEEEAERRKERCK	MORC2	746	Q9Y6X9
CKRNLVLAREREEKE	PPP1R37	451	O75864
EKRRRISTEEKLEEC	CYP19A1	261	P11511
IKRIEERCRRKLEDS	DSP	1906	P15924
KERRIEILESECKVA	HOOK1	641	Q9UJC3
CRKRVQLEELRDDLE	COG2	36	Q14746
KCERIRGRKATLDEI	HDAC5	726	Q9UQL6
KDRVICELRAELERL	CCDC102B	341	Q68D86
EEEFLRVCRLKEKEL	CARD11	1096	Q9BXL7
RKLQERVERCAKEAE	PACSIN3	186	Q9UKS6
DCDRRTEVAKKRLAE	LUC7L2	96	Q9Y383
ERKRRVELRCLELEE	SRRM2	61	Q9UQ35
EEREVVRVRVKKCES	TBC1D25	31	Q3MII6
RLLRACFEETKKEEI	SYNE2	596	Q8WXH0
ELRTKEKELRSREEE	MAP3K21	431	Q5TCX8
KDRTDCKERIRPLSD	MAP3K21	601	Q5TCX8
ICFEERRDELSERLK	KCNV2	201	Q8TDN2
KRAKRKEREEIECIE	PTCHD4	821	Q6ZW05
ILKRVEERSERECTA	NGEF	426	Q8N5V2
EEKCQSEIRKLRREL	NAV2	1686	Q8IVL1
TEKEREKLLCEGRRE	SIN3B	811	O75182
KACRILLRELEETRD	SPATA31E1	121	Q6ZUB1
CRAKEERRIDLELKL	AFAP1L1	676	Q8TED9
DEAVEECVRTRRRKV	RNF31	566	Q96EP0
RKKQLEERCRVEESI	TBC1D14	356	Q9P2M4
LRVLKKELEDCEVFR	TRIM7	181	Q9C029
VRTCKKLREEEAARL	TRIB2	141	Q92519
KRLTTDNRREICDKE	STK10	711	O94804
SRLIEKECLEKESRD	SUGP2	176	Q8IX01
EERLTELKRQCVEKE	SMC6	241	Q96SB8
EKSISERREDRKLDE	SMIM12	46	Q96EX1
LCEGEIIDKRRERET	SMC5	416	Q8IY18