Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phospholipid binding	RAB35 CPNE8 DEPTOR PIGK ANXA8L1 ANXA8 CPS1 TEC DENND1A IQGAP1 ITPR1 CKMT2 MYOF PLD1 MCTP2 PCYT1B	3.22e-06	548	148	16	GO:0005543
GeneOntologyMolecularFunction	lipid binding	RAB35 CPNE8 DEPTOR PIGK ANXA8L1 RBP1 RBP2 ANXA8 FABP9 CPS1 TEC DENND1A FABP4 IQGAP1 ITPR1 CKMT2 MYOF CYP2R1 DROSHA PLD1 MCTP2 PCYT1B	3.77e-06	988	148	22	GO:0008289
GeneOntologyMolecularFunction	formyltetrahydrofolate dehydrogenase activity	ALDH1L1 ALDH1L2	5.46e-05	2	148	2	GO:0016155
GeneOntologyMolecularFunction	calcium ion binding	SPTAN1 ANXA8L1 ANXA8 PCDHA3 CPS1 CALML6 PCDH20 IQGAP1 ITPR1 MYOF CDH20 GUCA1A ANKEF1 MCTP2 CDH7 PCDH9	1.42e-04	749	148	16	GO:0005509
GeneOntologyMolecularFunction	actin filament binding	SYNE1 SPTAN1 ANXA8L1 ANXA8 IQGAP1 FGD4 CTNNA2 PLEC	2.97e-04	227	148	8	GO:0051015
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	GRIN2B GRM1	3.24e-04	4	148	2	GO:0099583
GeneOntologyMolecularFunction	guanine/thymine mispair binding	MSH3 MLH1	3.24e-04	4	148	2	GO:0032137
GeneOntologyMolecularFunction	sodium channel activity	GRIK2 SCN1A SCN2A SCN7A	5.95e-04	52	148	4	GO:0005272
GeneOntologyMolecularFunction	ATP-dependent activity	ATP7B KIF27 KIF21A MSH3 HELQ ACSL4 G3BP1 ATP2C2 ERCC6L2 MLH1 ATP6V0D2 SNRNP200 AQR	6.65e-04	614	148	13	GO:0140657
GeneOntologyMolecularFunction	phosphatase binding	IQGAP1 ITPR1 MAGI2 CSK PIK3R2 SKAP1 DLG3 ANAPC5	8.05e-04	264	148	8	GO:0019902
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN2A SCN7A	9.15e-04	26	148	3	GO:0005248
GeneOntologyMolecularFunction	alkali metal ion binding	CPS1 SCN1A SCN2A	9.15e-04	26	148	3	GO:0031420
GeneOntologyMolecularFunction	protein phosphatase binding	IQGAP1 ITPR1 CSK PIK3R2 SKAP1 DLG3 ANAPC5	9.85e-04	210	148	7	GO:0019903
GeneOntologyMolecularFunction	calcium-dependent phospholipid binding	CPNE8 ANXA8L1 ANXA8 MCTP2	1.02e-03	60	148	4	GO:0005544
GeneOntologyMolecularFunction	glutamate receptor activity	GRIK2 GRIN2B GRM1	1.02e-03	27	148	3	GO:0008066
GeneOntologyMolecularFunction	extracellularly glutamate-gated ion channel activity	GRIK2 GRIN2B	1.12e-03	7	148	2	GO:0005234
GeneOntologyCellularComponent	somatodendritic compartment	PDE9A SYNE1 KIF21A DYNLT1 GRIK2 GRIN2B PALMD GRM1 DCTN1 DENND1A PABPC1 ITPR1 SEMA3A ACSL4 MAGI2 G3BP1 ATP6AP2 SCN1A PALM DLG3 SGCE PLEC EPHA5	1.77e-05	1228	148	23	GO:0036477
GeneOntologyCellularComponent	axon	ABI1 KIF21A SPTAN1 DYNLT1 GRIK2 GRIN2B GRM1 DCTN1 IQGAP1 SEMA3A ATP6AP2 SCN1A SCN2A PALM DLG3 CTNNA2 PLEC PCDH9 EPHA5	1.79e-05	891	148	19	GO:0030424
GeneOntologyCellularComponent	cell-cell junction	ATP7B SPTAN1 TEC IQGAP1 MAGI2 CDH20 CSK SCN1A SCN2A SKAP1 DLG3 CTNNA2 CDH7 PCDH9 EPHA5	2.03e-05	591	148	15	GO:0005911
GeneOntologyCellularComponent	sodium channel complex	GRIK2 SCN1A SCN2A SCN7A	4.99e-05	29	148	4	GO:0034706
GeneOntologyCellularComponent	cell leading edge	ABI1 PDE9A DYNLT1 DCTN1 PABPC1 IQGAP1 CDC37 FGD4 ATP6AP2 PALM SGCE CTNNA2 PLD1	5.82e-05	500	148	13	GO:0031252
GeneOntologyCellularComponent	anchoring junction	ATP7B SPTAN1 TEC PABPC1 IQGAP1 MAGI2 CDH20 G3BP1 CSK PIK3R2 SCN1A SCN2A SKAP1 DLG3 CTNNA2 PLEC CDH7 PCDH9 EPHA5	6.16e-05	976	148	19	GO:0070161
GeneOntologyCellularComponent	dendrite	SYNE1 KIF21A GRIK2 GRIN2B PALMD GRM1 DENND1A PABPC1 ITPR1 SEMA3A MAGI2 ATP6AP2 PALM DLG3 SGCE PLEC EPHA5	1.25e-04	858	148	17	GO:0030425
GeneOntologyCellularComponent	dendritic tree	SYNE1 KIF21A GRIK2 GRIN2B PALMD GRM1 DENND1A PABPC1 ITPR1 SEMA3A MAGI2 ATP6AP2 PALM DLG3 SGCE PLEC EPHA5	1.28e-04	860	148	17	GO:0097447
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN2A SCN7A	2.20e-04	17	148	3	GO:0001518
GeneOntologyCellularComponent	synaptic membrane	SYNE1 GRIK2 GRIN2B GRM1 DENND1A ITPR1 MAGI2 ATP6AP2 SCN1A SCN2A PALM DLG3 CTNNA2	2.65e-04	583	148	13	GO:0097060
GeneOntologyCellularComponent	sarcolemma	PDE9A ANXA8L1 ANXA8 SCN1A SCN2A SGCE PLEC	4.17e-04	190	148	7	GO:0042383
GeneOntologyCellularComponent	asymmetric synapse	ABI1 GRIK2 GRIN2B GRM1 ITPR1 SEMA3A MAGI2 DROSHA PALM DLG3 CTNNA2	6.02e-04	477	148	11	GO:0032279
GeneOntologyCellularComponent	protein complex involved in cell-cell adhesion	LGALS1 IZUMO1	7.33e-04	6	148	2	GO:0098635
GeneOntologyCellularComponent	late endosome	ATP7B ZMPSTE24 VPS33A ANXA8L1 ANXA8 GRIN2B ANKRD27 MAGI2 PLD1	8.55e-04	348	148	9	GO:0005770
GeneOntologyCellularComponent	membrane protein complex	PIGK SYNE1 VPS33A GRIK2 GRIN2B GRM1 DCTN1 TOMM70 CDH20 ATP6AP2 PIK3R2 SCN1A SCN2A SKAP1 SCN7A DLG3 SGCE ATP6V0D2 CTNNA2 SEC63 NNT CDH7	8.67e-04	1498	148	22	GO:0098796
GeneOntologyCellularComponent	neuron to neuron synapse	ABI1 GRIK2 GRIN2B GRM1 ITPR1 SEMA3A MAGI2 DROSHA PALM DLG3 CTNNA2	1.27e-03	523	148	11	GO:0098984
GeneOntologyCellularComponent	postsynaptic density	ABI1 GRIK2 GRIN2B GRM1 ITPR1 MAGI2 DROSHA PALM DLG3 CTNNA2	1.43e-03	451	148	10	GO:0014069
GeneOntologyCellularComponent	catenin complex	CDH20 CTNNA2 CDH7	1.48e-03	32	148	3	GO:0016342
GeneOntologyCellularComponent	platelet dense tubular network membrane	IRAG1 ITPR1	1.73e-03	9	148	2	GO:0031095
GeneOntologyCellularComponent	photoreceptor inner segment	DYNLT1 MAGI2 GUCA1A RP1	2.29e-03	78	148	4	GO:0001917
GeneOntologyCellularComponent	cell body	PDE9A RBP1 DYNLT1 GRIK2 GRIN2B GRM1 DCTN1 DENND1A ITPR1 ACSL4 G3BP1 ATP6AP2 SCN1A DLG3 EPHA5	2.49e-03	929	148	15	GO:0044297
GeneOntologyCellularComponent	filtration diaphragm	IQGAP1 MAGI2	2.63e-03	11	148	2	GO:0036056
GeneOntologyCellularComponent	slit diaphragm	IQGAP1 MAGI2	2.63e-03	11	148	2	GO:0036057
GeneOntologyCellularComponent	mismatch repair complex	MSH3 MLH1	2.63e-03	11	148	2	GO:0032300
GeneOntologyCellularComponent	platelet dense tubular network	IRAG1 ITPR1	2.63e-03	11	148	2	GO:0031094
HumanPheno	Bilateral facial palsy	SYNE1 ITPR1 PLEC	1.55e-06	3	60	3	HP:0430025
HumanPheno	Hypoesthesia	ATP7B SPTAN1 COQ6 FGD4 SMARCB1	8.49e-06	25	60	5	HP:0033748
Domain	iLBP	RBP1 RBP2 FABP9 FABP4	6.06e-06	16	146	4	IPR031259
Domain	Fatty_acid-bd	RBP1 RBP2 FABP9 FABP4	6.06e-06	16	146	4	IPR000463
Domain	FABP	RBP1 RBP2 FABP9 FABP4	6.06e-06	16	146	4	PS00214
Domain	Na_channel_asu	SCN1A SCN2A SCN7A	5.39e-05	10	146	3	IPR001696
Domain	Na_trans_assoc	SCN1A SCN2A SCN7A	5.39e-05	10	146	3	IPR010526
Domain	Na_trans_assoc	SCN1A SCN2A SCN7A	5.39e-05	10	146	3	PF06512
Domain	Paralemmin	PALMD PALM	6.07e-05	2	146	2	IPR004965
Domain	AnnexinVIII	ANXA8L1 ANXA8	6.07e-05	2	146	2	IPR009115
Domain	10_FTHF_DH	ALDH1L1 ALDH1L2	6.07e-05	2	146	2	IPR011407
Domain	Paralemmin	PALMD PALM	6.07e-05	2	146	2	PF03285
Domain	Lipocln_cytosolic_FA-bd_dom	RBP1 RBP2 FABP9 FABP4	1.38e-04	34	146	4	IPR000566
Domain	Lipocalin	RBP1 RBP2 FABP9 FABP4	1.38e-04	34	146	4	PF00061
Domain	-	RBP1 RBP2 FABP9 FABP4	1.55e-04	35	146	4	2.40.128.20
Domain	-	ALDH1L1 ALDH1L2	1.81e-04	3	146	2	3.10.25.10
Domain	GART_AS	ALDH1L1 ALDH1L2	1.81e-04	3	146	2	IPR001555
Domain	Formyl_trans_C	ALDH1L1 ALDH1L2	1.81e-04	3	146	2	PF02911
Domain	Formyl_trans_C	ALDH1L1 ALDH1L2	1.81e-04	3	146	2	IPR005793
Domain	GART	ALDH1L1 ALDH1L2	1.81e-04	3	146	2	PS00373
Domain	Calycin-like	RBP1 RBP2 FABP9 FABP4	1.94e-04	37	146	4	IPR011038
Domain	Calycin	RBP1 RBP2 FABP9 FABP4	1.94e-04	37	146	4	IPR012674
Domain	SH3_1	ABI1 SPTAN1 TEC CSK PIK3R2 SKAP1 DLG3	3.09e-04	164	146	7	PF00018
Domain	Sec63	SEC63 SNRNP200	3.60e-04	4	146	2	PF02889
Domain	Sec63	SEC63 SNRNP200	3.60e-04	4	146	2	SM00973
Domain	Sec63-dom	SEC63 SNRNP200	3.60e-04	4	146	2	IPR004179
Domain	-	ALDH1L1 ALDH1L2	3.60e-04	4	146	2	3.40.50.170
Domain	Formyl_transf_N	ALDH1L1 ALDH1L2	3.60e-04	4	146	2	IPR002376
Domain	Formyl_trans_N	ALDH1L1 ALDH1L2	3.60e-04	4	146	2	PF00551
Domain	-	ALDH1L1 ALDH1L2	5.98e-04	5	146	2	1.10.1200.10
Domain	PHOSPHOPANTETHEINE	ALDH1L1 ALDH1L2	5.98e-04	5	146	2	PS00012
Domain	Formyl_transferase_C-like	ALDH1L1 ALDH1L2	5.98e-04	5	146	2	IPR011034
Domain	PP-binding	ALDH1L1 ALDH1L2	5.98e-04	5	146	2	PF00550
Domain	ACP_DOMAIN	ALDH1L1 ALDH1L2	5.98e-04	5	146	2	PS50075
Domain	Na_trans_cytopl	SCN1A SCN2A	8.92e-04	6	146	2	PF11933
Domain	Na_trans_cytopl	SCN1A SCN2A	8.92e-04	6	146	2	IPR024583
Domain	PP-bd_ACP	ALDH1L1 ALDH1L2	8.92e-04	6	146	2	IPR009081
Domain	-	RPGRIP1 CPNE8 MYOF SEC63 MCTP2 SNRNP200	1.09e-03	148	146	6	2.60.40.150
Domain	Spectrin_repeat	SYNE1 SPTAN1 PLEC	1.47e-03	29	146	3	IPR002017
Domain	SH3	ABI1 SPTAN1 TEC CSK PIK3R2 SKAP1 DLG3	1.57e-03	216	146	7	SM00326
Domain	SH3	ABI1 SPTAN1 TEC CSK PIK3R2 SKAP1 DLG3	1.57e-03	216	146	7	PS50002
Domain	Cadherin_CS	PCDHA3 PCDH20 CDH20 CDH7 PCDH9	1.66e-03	109	146	5	IPR020894
Domain	CH	SYNE1 IQGAP1 PLEC TAGLN	1.68e-03	65	146	4	SM00033
Domain	SH3_domain	ABI1 SPTAN1 TEC CSK PIK3R2 SKAP1 DLG3	1.74e-03	220	146	7	IPR001452
Domain	C2_dom	RPGRIP1 CPNE8 MYOF SEC63 MCTP2 SNRNP200	1.84e-03	164	146	6	IPR000008
Domain	CADHERIN_1	PCDHA3 PCDH20 CDH20 CDH7 PCDH9	1.94e-03	113	146	5	PS00232
Domain	Cadherin	PCDHA3 PCDH20 CDH20 CDH7 PCDH9	1.94e-03	113	146	5	PF00028
Domain	SPEC	SYNE1 SPTAN1 PLEC	1.97e-03	32	146	3	SM00150
Domain	Spectrin/alpha-actinin	SYNE1 SPTAN1 PLEC	1.97e-03	32	146	3	IPR018159
Domain	CADHERIN_2	PCDHA3 PCDH20 CDH20 CDH7 PCDH9	2.02e-03	114	146	5	PS50268
Domain	-	PCDHA3 PCDH20 CDH20 CDH7 PCDH9	2.02e-03	114	146	5	2.60.40.60
Domain	CA	PCDHA3 PCDH20 CDH20 CDH7 PCDH9	2.10e-03	115	146	5	SM00112
Domain	Cadherin-like	PCDHA3 PCDH20 CDH20 CDH7 PCDH9	2.18e-03	116	146	5	IPR015919
Domain	CH	SYNE1 IQGAP1 PLEC TAGLN	2.20e-03	70	146	4	PF00307
Domain	-	SYNE1 IQGAP1 PLEC TAGLN	2.32e-03	71	146	4	1.10.418.10
Domain	Cadherin	PCDHA3 PCDH20 CDH20 CDH7 PCDH9	2.35e-03	118	146	5	IPR002126
Pathway	REACTOME_NEPHRIN_FAMILY_INTERACTIONS	SPTAN1 IQGAP1 MAGI2 PIK3R2	3.65e-05	23	118	4	M913
Pathway	REACTOME_CELL_CELL_COMMUNICATION	SDK2 SPTAN1 IQGAP1 MAGI2 PIK3R2 TNRC6A PLEC CDH7	4.69e-05	155	118	8	M522
Pathway	WP_ADHD_AND_AUTISM_ASD_PATHWAYS	ATG10 DEPTOR GRIN2B ALDH1L1 GRM1 ALDH1L2 PIK3R2 SCN1A SCN2A SCN7A DLG3 ALPI	5.79e-05	367	118	12	M48346
Pathway	REACTOME_CGMP_EFFECTS	PDE9A IRAG1 ITPR1	6.57e-05	10	118	3	MM15054
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTAN1 SCN1A SCN2A SCN7A	1.23e-04	31	118	4	M877
Pathway	REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE	PDE9A IRAG1 ITPR1	1.54e-04	13	118	3	MM15015
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	CCPG1 ZMPSTE24 PIGK KIF21A SPTAN1 VPS33A COQ6 EXOSC3 PABPC1 LGALS1 CDC37 MYOF G3BP1 ATP6AP2 MLH1 HNRNPA0 SMARCB1 PDIA5 TTC17 OXSR1 CTNNA2 SEC63 AQR ALPI	1.84e-09	1297	150	24	33545068
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	CCPG1 RAB25 IRS4 ZMPSTE24 SYNE1 SPTAN1 VPS33A COQ6 ALDH1L1 PABPC1 LGALS1 IQGAP1 CDC37 TOMM70 MYOF GUF1 PLEC NNT SNRNP200	2.31e-09	807	150	19	30575818
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	RAB35 ABI1 PDK1 SPTAN1 VPS33A ANXA8L1 ANXA8 ZDBF2 GRIN2B PALMD CMAS ITPR1 MAGI2 G3BP1 SCN1A TNRC6A HNRNPA0 PALM DLG3 CTNNA2 PLEC	2.25e-08	1139	150	21	36417873
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	KIF27 KIF21A SPTAN1 VPS33A DCTN1 IQGAP1 PPP2R1B CSK YLPM1 MLH1 HNRNPA0 OXSR1 PLEC SNRNP200 AQR	3.85e-08	582	150	15	20467437
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	KRT6A ABI1 PDK1 SYNE1 SPTAN1 GRIN2B ALDH1L1 GRM1 CMAS DCTN1 PABPC1 IQGAP1 MAGI2 TOMM70 G3BP1 FGD4 SCN2A HNRNPA0 PALM DLG3 CTNNA2 PLEC SNRNP200	5.55e-08	1431	150	23	37142655
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	USP34 RAB35 PIGK PDK1 U2AF1L4 PABPC1 F13A1 LGALS1 FABP4 IQGAP1 ITPR1 SEMA3A ACSL4 MAGI2 PNPT1 GUF1 ALDH1L2 SUMF1 PDIA5 PLEC SEC63 SNRNP200 SMAD4	7.12e-08	1451	150	23	30550785
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	USP34 NRDE2 SIK1 TEC CMAS DCTN1 LYST F13A1 LGALS1 DNTTIP2 CDC37 MYOF LIMK2 CSK PIK3R2 PDIA5 PLEC ANAPC5	8.78e-08	910	150	18	36736316
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	NRDE2 KRT6A CPNE8 PIGK SPTAN1 SSRP1 DENND1A PABPC1 IQGAP1 ACSL4 PNPT1 G3BP1 DROSHA YLPM1 TNRC6A SMARCB1 PDIA5 RRP7A CTNNA2 PLD1 PLEC SEC63	1.15e-07	1371	150	22	36244648
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	NRDE2 ABI1 PIGK SYNE1 EXOSC3 SSRP1 CMAS DENND1A IQGAP1 TOMM70 MYOF GUF1 FGD4 DROSHA ATP6AP2 TNRC6A MLH1 DLG3 RRP7A CTNNA2 SEC63 ANAPC5 AQR	1.24e-07	1497	150	23	31527615
Pubmed	NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.	SYNE1 SPTAN1 CPS1 PABPC1 LGALS1 IQGAP1 PNPT1 G3BP1 HNRNPA0 PLEC SNRNP200	2.40e-07	333	150	11	32665550
Pubmed	LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.	RAB35 KRT6A SPTAN1 SSRP1 CPS1 PABPC1 LGALS1 IQGAP1 ACSL4 G3BP1 HNRNPA0 TDRD6 PLEC ALPI	2.48e-07	580	150	14	35676659
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RPGRIP1 KRT6A IRS4 ZMPSTE24 NLRP7 SYNE1 KIF21A SPTAN1 COQ6 SIK1 SSRP1 DCTN1 LYST PABPC1 DNTTIP2 IQGAP1 ACSL4 YLPM1 HNRNPA0 PALM DLG3 PLEC	2.72e-07	1442	150	22	35575683
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	CPNE8 ATP7B PIGK VPS33A LYST ANKRD27 ITPR1 RUFY2 ACSL4 ATP6AP2 PIK3R2 PLD1 SEC63	3.22e-07	504	150	13	34432599
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	KIF21A SPTAN1 EXOSC3 MSH3 SSRP1 CMAS DCTN1 PABPC1 ANKRD27 LGALS1 DNTTIP2 IQGAP1 CDC37 ACSL4 GUF1 G3BP1 MLH1 HNRNPA0 PLEC SNRNP200 AQR	3.95e-07	1353	150	21	29467282
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CPNE8 CCPG1 PDK1 SYNE1 SPTAN1 SSRP1 CMAS DCTN1 DNTTIP2 ITPR1 CDC37 PNPT1 GUF1 ATP6AP2 PIK3R2 HNRNPA0 PALM PDIA5 TTC17 SEC63 SNRNP200 AQR	4.56e-07	1487	150	22	33957083
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	NRDE2 RAB25 ATG10 ODAD4 DCTN1 PABPC1 LGALS1 FABP4 IQGAP1 CDC37 MAGI2 G3BP1 CCNA1 DLG3 OXSR1 TAGLN SEC63 SNRNP200 NACA4P ALPI	7.27e-07	1284	150	20	17353931
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	SYNE1 SPTAN1 SSRP1 CPS1 CMAS DCTN1 PABPC1 LGALS1 DNTTIP2 IQGAP1 ITPR1 G3BP1 HNRNPA0 RRP7A PLEC MCTP2 SNRNP200	8.10e-07	949	150	17	36574265
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	CCPG1 EXOSC3 SSRP1 CPS1 DCTN1 PABPC1 DNTTIP2 G3BP1 DROSHA HNRNPA0 SMARCB1 RRP7A PLD1 DOT1L SNRNP200 AQR	8.76e-07	847	150	16	35850772
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	IRS4 KIF27 SYNE1 SPTAN1 MSH3 SSRP1 GRM1 DCTN1 PABPC1 DNTTIP2 IQGAP1 CDC37 TOMM70 G3BP1 HNRNPA0 RRP7A TDRD6 SEC63 NNT SNRNP200 AQR	9.11e-07	1425	150	21	30948266
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 IRS4 SPTAN1 PABPC1 DNTTIP2 IQGAP1 PNPT1 G3BP1 YLPM1 RRP7A PLEC NNT SNRNP200 AQR	1.01e-06	653	150	14	22586326
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	USP34 CPNE8 IRS4 PIGK NT5C3A SPTAN1 EXOSC3 SSRP1 DENND1A IQGAP1 ITPR1 CDC37 TOMM70 MYOF PPP2R1B G3BP1 HNRNPA0 CTNNA2 SEC63 SNRNP200 ALPI	1.08e-06	1440	150	21	30833792
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	NRDE2 RAB35 KRT6A PDK1 SYNE1 SPTAN1 SSRP1 CMAS PNPT1 DROSHA YLPM1 HNRNPA0 SMARCB1 PDIA5 PLEC SEC63 SNRNP200 AQR	1.08e-06	1082	150	18	38697112
Pubmed	The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.	ABI1 TEC CDC37 CSK PIK3R2 PLEC	1.45e-06	81	150	6	20697350
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	RAB35 KIF21A RBP1 SSRP1 CMAS DCTN1 PABPC1 LGALS1 IQGAP1 CDC37 ACSL4 TOMM70 SETDB1 MYOF PPP2R1B G3BP1 YLPM1 OXSR1 TAGLN NNT	1.90e-06	1367	150	20	32687490
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	KRT6A CPNE8 SPTAN1 BTBD10 EXOSC3 SSRP1 CMAS PABPC1 LGALS1 DNTTIP2 IQGAP1 CDC37 MYOF G3BP1 HNRNPA0 PLEC SEC63 SNRNP200 AQR	2.19e-06	1257	150	19	36526897
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	CPNE8 SDK2 SPTAN1 GRIK2 GRIN2B SCN1A DLG3 CTNNA2	2.43e-06	197	150	8	36604605
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	SYNE1 ANXA8L1 ANXA8 DYNLT1 CPS1 DCTN1 PABPC1 LGALS1 IQGAP1 ITPR1 PPP2R1B CSK YLPM1 HNRNPA0 SMARCB1 ANAPC5 SNRNP200 AQR	2.71e-06	1155	150	18	20360068
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP34 PDE9A SYNE1 KIF21A SPTAN1 MSH3 GRIN2B CMAS DCTN1 IQGAP1 RUFY2 MAGI2 SETDB1 GUF1 DROSHA YLPM1 TTC17 PLEC SNRNP200	3.01e-06	1285	150	19	35914814
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	IRS4 EXOSC3 SSRP1 DNTTIP2 ITPR1 SETDB1 PPP2R1B G3BP1 YLPM1 ANAPC5 AQR	3.62e-06	440	150	11	34244565
Pubmed	Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.	IQGAP1 MYOF G3BP1 PLEC TAGLN SNRNP200 SMAD4	4.63e-06	152	150	7	16009940
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	KIF21A SPTAN1 U2AF1L4 SSRP1 CMAS DCTN1 PABPC1 IQGAP1 CDC37 PNPT1 MYOF G3BP1 PIK3R2 MLH1 HNRNPA0 OXSR1 DOT1L AQR	7.77e-06	1247	150	18	27684187
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	KIF27 SPTAN1 CPS1 DCTN1 IQGAP1 MYOF CTNNA2 PLEC	8.90e-06	235	150	8	28378594
Pubmed	USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells.	SPTAN1 ALDH1L1 CPS1	9.23e-06	10	150	3	36653359
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RAB35 KRT6A CPNE8 IRS4 SYNE1 SSRP1 PABPC1 DNTTIP2 IQGAP1 G3BP1 YLPM1 HNRNPA0 PLEC NNT SNRNP200 AQR	9.77e-06	1024	150	16	24711643
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	SYNE1 SSRP1 PABPC1 PCDH20 DNTTIP2 PNPT1 G3BP1 DROSHA YLPM1 TNRC6A NBPF10 HNRNPA0 SNRNP200 AQR	1.15e-05	807	150	14	22681889
Pubmed	Defining the membrane proteome of NK cells.	KRT6A ATP7B ZMPSTE24 PIGK MSH3 CMAS DCTN1 PABPC1 ANKRD27 ITPR1 ACSL4 TOMM70 MLH1 PLD1 MCTP2 NNT AQR	1.27e-05	1168	150	17	19946888
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	ABI1 SYNE1 SPTAN1 GRIK2 GRIN2B DCTN1 DLG3 CTNNA2	1.43e-05	251	150	8	27507650
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	NRDE2 KRT6A SPTAN1 EXOSC3 PABPC1 MYOF G3BP1 YLPM1 TNRC6A OXSR1 PLEC TAGLN NNT	1.67e-05	724	150	13	36232890
Pubmed	Loss of MSH3 protein expression is frequent in MLH1-deficient colorectal cancer and is associated with disease progression.	MSH3 MLH1	1.85e-05	2	150	2	14871813
Pubmed	Binding affinities of CRBPI and CRBPII for 9-cis-retinoids.	RBP1 RBP2	1.85e-05	2	150	2	21382444
Pubmed	TaqI polymorphisms at the annexin VIII locus (ANX8).	ANXA8L1 ANXA8	1.85e-05	2	150	2	1364010
Pubmed	Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.	SCN1A SCN2A	1.85e-05	2	150	2	10827969
Pubmed	Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.	SCN1A SCN2A	1.85e-05	2	150	2	19694741
Pubmed	Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes.	ANXA8L1 ANXA8	1.85e-05	2	150	2	29306076
Pubmed	Galectin-1 and semaphorin-3A are two soluble factors conferring T-cell immunosuppression to bone marrow mesenchymal stem cell.	LGALS1 SEMA3A	1.85e-05	2	150	2	19886821
Pubmed	Differential expression of two sodium channel subtypes in human brain.	SCN1A SCN2A	1.85e-05	2	150	2	1317301
Pubmed	Bone matrix regulates osteoclast differentiation and annexin A8 gene expression.	ANXA8L1 ANXA8	1.85e-05	2	150	2	21344395
Pubmed	Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein.	RBP1 RBP2	1.85e-05	2	150	2	2992469
Pubmed	Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.	SCN1A SCN2A	1.85e-05	2	150	2	31439038
Pubmed	SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo.	GRIN2B DLG3	1.85e-05	2	150	2	8780649
Pubmed	Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer.	ANXA8L1 ANXA8	1.85e-05	2	150	2	16203777
Pubmed	Frequent LOH at hMLH1, a highly variable SNP in hMSH3, and negligible coding instability in ovarian cancer.	MSH3 MLH1	1.85e-05	2	150	2	12014680
Pubmed	Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.	SCN1A SCN2A	1.85e-05	2	150	2	15249644
Pubmed	Annexins: from structure to function.	ANXA8L1 ANXA8	1.85e-05	2	150	2	11917092
Pubmed	Gecko iota-crystallin: how cellular retinol-binding protein became an eye lens ultraviolet filter.	RBP1 RBP2	1.85e-05	2	150	2	10725366
Pubmed	[Association of genetic polymorphisms and haplotypes in hMLH1 and hMSH3 gene with the risk of papillary thyroid carcinoma].	MSH3 MLH1	1.85e-05	2	150	2	18683134
Pubmed	Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16.	ITPR1 SUMF1	1.85e-05	2	150	2	17932120
Pubmed	Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation.	CDH20 CDH7	1.85e-05	2	150	2	15273735
Pubmed	SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.	SCN1A SCN2A	1.85e-05	2	150	2	30693367
Pubmed	Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.	SCN1A SCN2A	1.85e-05	2	150	2	29649454
Pubmed	Reduced migration of MLH1 deficient colon cancer cells depends on SPTAN1.	SPTAN1 MLH1	1.85e-05	2	150	2	24456667
Pubmed	Deciphering protein dynamics changes along the pathway of retinol uptake by cellular retinol-binding proteins 1 and 2.	RBP1 RBP2	1.85e-05	2	150	2	29567208
Pubmed	Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63.	ANXA8L1 ANXA8	1.85e-05	2	150	2	24769558
Pubmed	Downregulation of SPTAN1 is related to MLH1 deficiency and metastasis in colorectal cancer.	SPTAN1 MLH1	1.85e-05	2	150	2	30856214
Pubmed	Enhanced diacylglycerol production by phospholipase D activation is responsible for abnormal increase in concanavalin A cap formation in polymorphonuclear leukocytes from Chediak-Higashi syndrome (beige) mice.	LYST PLD1	1.85e-05	2	150	2	24830864
Pubmed	Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families.	ITPR1 SUMF1	1.85e-05	2	150	2	18579805
Pubmed	The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes.	RAB35 DENND1A	1.85e-05	2	150	2	20159556
Pubmed	The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene.	RBP1 RBP2	1.85e-05	2	150	2	3029082
Pubmed	Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.	SCN1A SCN2A	1.85e-05	2	150	2	33096315
Pubmed	Annexins: linking Ca2+ signalling to membrane dynamics.	ANXA8L1 ANXA8	1.85e-05	2	150	2	15928709
Pubmed	Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.	SCN1A SCN2A	1.85e-05	2	150	2	26311622
Pubmed	Aberrant methylation of DNA mismatch repair genes in elderly patients with sporadic gastric carcinoma: A comparison with younger patients.	MSH3 MLH1	1.85e-05	2	150	2	19894224
Pubmed	ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase.	ALDH1L1 ALDH1L2	1.85e-05	2	150	2	20498374
Pubmed	A novel form of low-frequency hippocampal mossy fiber plasticity induced by bimodal mGlu1 receptor signaling.	GRIK2 GRM1	1.85e-05	2	150	2	22114260
Pubmed	PALML, a novel paralemmin-related gene mapping on human chromosome 1p21.	PALMD PALM	1.85e-05	2	150	2	11707320
Pubmed	Genetic Polymorphism of Mismatch Repair Genes and Susceptibility to Prostate Cancer.	MSH3 MLH1	1.85e-05	2	150	2	31953835
Pubmed	The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.	SCN1A SCN2A	1.85e-05	2	150	2	21377452
Pubmed	Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.	ANXA8L1 ANXA8	1.85e-05	2	150	2	25803307
Pubmed	Direct amplification of a single dissected chromosomal segment by polymerase chain reaction: a human brain sodium channel gene is on chromosome 2q22-q23.	SCN2A SCN7A	1.85e-05	2	150	2	1846440
Pubmed	Regulation of autophagy by the inositol trisphosphate receptor.	ATG10 ITPR1	1.85e-05	2	150	2	17256008
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	CCPG1 IRS4 GRM1 PABPC1 PIK3R2 SCN1A YLPM1 SGCE OXSR1 PLEC	1.89e-05	430	150	10	35044719
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ABI1 SYNE1 KIF21A SPTAN1 GRIK2 GRIN2B GRM1 DCTN1 PABPC1 IQGAP1 MAGI2 G3BP1 YLPM1 DLG3 CTNNA2	1.95e-05	963	150	15	28671696
Pubmed	Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.	ABI1 KIF21A DCTN1 SGCE	1.97e-05	37	150	4	27565344
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	SPTAN1 CPS1 PABPC1 IQGAP1 MYOF G3BP1 PLEC NNT SNRNP200	1.99e-05	344	150	9	30333137
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	USP34 KRT6A IRS4 TEC DCTN1 PABPC1 G3BP1 ALDH1L2 HNRNPA0 CTNNA2 SEC63 ANAPC5 SNRNP200 AQR SMAD4	2.14e-05	971	150	15	33306668
Pubmed	Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.	GRIK2 GRIN2B GRM1	2.18e-05	13	150	3	20859245
Pubmed	Agrin has a pathological role in the progression of oral cancer.	IRS4 SYNE1 SPTAN1 PABPC1 CDC37 CKMT2 SNRNP200	2.50e-05	197	150	7	29872149
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	KRT6A IRS4 PDK1 SYNE1 NT5C3A ZDBF2 SSRP1 CMAS ITPR1 CDC37 ACSL4 PNPT1 TOMM70 GUF1 ALDH1L2 ATP6AP2 TTC17 SEC63 NNT	2.55e-05	1496	150	19	32877691
Pubmed	Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.	ABI1 GRIN2B GRM1	2.76e-05	14	150	3	21795692
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	KRT6A IRS4 DCTN1 IQGAP1 YLPM1 SNRNP200 AQR	2.93e-05	202	150	7	24639526
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	USP34 NRDE2 CCPG1 ITPR1 MAGI2 MYOF DLG3 PLEC ALPI	3.04e-05	363	150	9	14691545
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	KRT6A SPTAN1 MSH3 PABPC1 DNTTIP2 IQGAP1 MYOF YLPM1 HNRNPA0 PALM PLEC SNRNP200	3.15e-05	660	150	12	32780723
Pubmed	Confirmation of quantitative trait loci for alcohol preference in mice.	SCN1A SCN2A SCN7A	3.44e-05	15	150	3	9726281
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	KRT6A KIF21A SPTAN1 U2AF1L4 EXOSC3 SSRP1 CPS1 DCTN1 PABPC1 LGALS1 DNTTIP2 IQGAP1 PNPT1 G3BP1 HNRNPA0 PLEC SNRNP200 AQR	4.14e-05	1415	150	18	28515276
Pubmed	DNA cloning using in vitro site-specific recombination.	CPNE8 ATG10 DEPTOR NT5C3A ODAD4 GRM1 ANKRD27 LGALS1 CDC37 LIMK2 CCNA1 NNT EPHA5	4.32e-05	794	150	13	11076863
Pubmed	RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells.	RAB35 CSK PIK3R2 PALM	5.13e-05	47	150	4	29212245
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	IRS4 SPTAN1 DCTN1 IQGAP1 ALDH1L2 HNRNPA0 SNRNP200	5.19e-05	221	150	7	29991511
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	IRS4 DYNLT1 DCTN1 PABPC1 IQGAP1 CDC37 PNPT1 G3BP1 YLPM1 HNRNPA0 PLEC ANAPC5 SNRNP200	5.22e-05	809	150	13	32129710
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	IRS4 SSRP1 PABPC1 IQGAP1 ACSL4 G3BP1 PIK3R2 HNRNPA0 SMARCB1 SNRNP200	5.30e-05	486	150	10	30940648
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	SDK2 G3BP1 ATP6AP2 YLPM1 TNRC6A OXSR1 PLEC EPHA5	5.34e-05	302	150	8	30561431
Interaction	AGR2 interactions	CCPG1 RAB25 IRS4 ZMPSTE24 SYNE1 SPTAN1 VPS33A COQ6 ALDH1L1 PABPC1 LGALS1 IQGAP1 CDC37 TOMM70 MYOF GUF1 GUCA1A MLH1 PLEC NNT SNRNP200	3.86e-06	934	146	21	int:AGR2
Interaction	DSCAM interactions	SDK2 SYNE1 KIF21A IQGAP1 RUFY2 MAGI2 GUF1 TTC17 PLEC	4.41e-06	171	146	9	int:DSCAM
Interaction	GRID2 interactions	GRIK2 GRIN2B ITPR1 MAGI2	1.75e-05	22	146	4	int:GRID2
Interaction	KRT6C interactions	KRT6A DCTN1 TRIM7 PIK3R2 SMARCB1 PLEC	1.88e-05	76	146	6	int:KRT6C
Interaction	RAB7A interactions	RAB35 CPNE8 RAB25 ATG10 ATP7B PIGK VPS33A DCTN1 LYST ANKRD27 ITPR1 RUFY2 ACSL4 MYOF PPP2R1B ATP6AP2 PIK3R2 PLD1 SEC63	2.25e-05	886	146	19	int:RAB7A
Interaction	SRC interactions	SPTAN1 GRIN2B GRM1 PABPC1 PCDH20 IQGAP1 TRIM7 CDC37 CSK SKAP1 IZUMO1 CCNA1 HNRNPA0 SMARCB1 PLD1 AQR	2.63e-05	664	146	16	int:SRC
Interaction	SNW1 interactions	KIF27 KIF21A SPTAN1 SSRP1 DCTN1 PABPC1 IQGAP1 PPP2R1B CSK MLH1 HNRNPA0 OXSR1 PLEC DOT1L SNRNP200 AQR SMAD4	3.00e-05	747	146	17	int:SNW1
Interaction	ITGB3 interactions	PDK1 SPTAN1 IQGAP1 MYOF CSK PLEC NNT SNRNP200	3.41e-05	170	146	8	int:ITGB3
Interaction	ROR1 interactions	SSRP1 TEC CDC37 PIK3R2 SMARCB1 PLEC SEC63	3.73e-05	126	146	7	int:ROR1
Interaction	ACER3 interactions	CSK YLPM1 MLH1	5.89e-05	11	146	3	int:ACER3
Interaction	AXDND1 interactions	SYNE1 CSK PLEC	5.89e-05	11	146	3	int:AXDND1
Interaction	EXO1 interactions	MSH3 SSRP1 MLH1 CCNA1 PLEC	6.27e-05	58	146	5	int:EXO1
Interaction	KCTD13 interactions	KRT6A ABI1 PDK1 SYNE1 SPTAN1 GRIN2B ALDH1L1 GRM1 CMAS DCTN1 PABPC1 IQGAP1 CDC37 MAGI2 TOMM70 G3BP1 FGD4 SCN2A HNRNPA0 PALM DLG3 CTNNA2 PLEC SNRNP200	6.33e-05	1394	146	24	int:KCTD13
Interaction	LYN interactions	RAB35 CPNE8 SDK2 ABI1 IRS4 SPTAN1 DYNLT1 TEC IQGAP1 ITPR1 CDC37 CSK PIK3R2 SKAP1 PALM PLD1	6.90e-05	720	146	16	int:LYN
Interaction	KIF20A interactions	PIGK SYNE1 SPTAN1 SIK1 SSRP1 CPS1 DCTN1 PABPC1 LGALS1 TRIM7 ITPR1 ACSL4 PIEZO2 G3BP1 YLPM1 TNRC6A HNRNPA0 SMARCB1 PLEC SNRNP200	7.34e-05	1052	146	20	int:KIF20A
GeneFamily	Fatty acid binding protein family	RBP1 RBP2 FABP9 FABP4	2.31e-06	16	111	4	550
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN2A	1.31e-03	9	111	2	1203
GeneFamily	X-linked mental retardation\|RNA helicases	HELQ SNRNP200	1.98e-03	11	111	2	1168
GeneFamily	Non-clustered protocadherins	PCDH20 PCDH9	2.37e-03	12	111	2	21
GeneFamily	CD molecules\|Type II classical cadherins	CDH20 CDH7	2.79e-03	13	111	2	1186
GeneFamily	Annexins\|Endogenous ligands	ANXA8L1 ANXA8	2.79e-03	13	111	2	404
Coexpression	VECCHI_GASTRIC_CANCER_EARLY_DN	CCPG1 NLRP7 RBP2 PELI2 PCDH20 F13A1 FABP4 MAGI2 CKMT2 ALDH1L2 SCN7A PCDH9	2.04e-06	382	149	12	M15472
Coexpression	BACOLOD_RESISTANCE_TO_ALKYLATING_AGENTS_UP	SEMA3A MYOF PPP2R1B SGCE	1.16e-05	25	149	4	M15908
Coexpression	GSE20715_WT_VS_TLR4_KO_6H_OZONE_LUNG_DN	NRDE2 ANXA8 DYNLT1 DCTN1 ATP6AP2 DLG3 OXSR1 AQR	1.98e-05	200	149	8	M4352
CoexpressionAtlas	DevelopingKidney_e15.5_Peripheral blastema_emap-27731_top-relative-expression-ranked_1000	USP34 PDE9A ADAMTS3 SSRP1 IRAG1 PCDH20 SEMA3A TOMM70 GUF1 PIEZO2 SCN1A SUMF1 SCN2A YLPM1 SCN7A ERCC6L2 SEC63 AQR	1.51e-05	819	147	18	gudmap_developingKidney_e15.5_Peripheral blastema_1000
CoexpressionAtlas	FacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_1000_k-means-cluster#2	PDE9A ADAMTS3 KIF21A GRIK2 FGD4 ZFHX2 CDH7 PCDH9 EPHA5	5.94e-05	248	147	9	Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_1000_K2
CoexpressionAtlas	DevelopingKidney_e13.5_podocyte cells_emap-27773_k-means-cluster#3_top-relative-expression-ranked_1000	SDK2 ADAMTS3 IRAG1 RUFY2 SEMA3A SUMF1 SCN2A MCTP2 AQR	6.32e-05	250	147	9	gudmap_developingKidney_e13.5_podocyte cells_1000_k3
CoexpressionAtlas	DevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_k-means-cluster#4_top-relative-expression-ranked_500	IRAG1 F13A1 LGALS1 SEMA3A SCN7A TAGLN MCTP2 PCDH9	6.57e-05	195	147	8	gudmap_developingKidney_e15.5_Pelvic Mesenchyme_500_k4
ToppCell	IPF-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	RBP1 GRIN2B FABP4 SEMA3A PIEZO2 P3H2 PALM SGCE PLD1 MCTP2	1.28e-09	195	150	10	de88e9d22044b4b3e29676ad02b3e9299cc920ad
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ALDH1L1 GRM1 ITPR1 ACSL4 MALRD1 SKAP1 SCN7A RP1 PCDH9	1.33e-08	184	150	9	e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR ACSL4 MYOF FGD4 SKAP1 SGCE RP1 CTNNA2 PCDH9	1.68e-08	189	150	9	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR ALDH1L1 GRM1 ITPR1 MALRD1 FGD4 SKAP1 RP1 PCDH9	1.76e-08	190	150	9	cc17ab84a9328124f146951c06be3eff9650d9fd
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RPGRIP1 RBP1 GRIN2B FABP4 SEMA3A CKMT2 PIEZO2 IZUMO1	1.17e-07	170	150	8	4848965bc7e9356c6601bb41eeea1553d2eea87e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR GRM1 ITPR1 ACSL4 MALRD1 SKAP1 RP1 PCDH9	2.54e-07	188	150	8	2ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCell	COVID-19-kidney-DCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DEPTOR PDE9A ALDH1L1 ACSL4 SCN2A SKAP1 MAP3K15 ATP6V0D2	2.54e-07	188	150	8	1d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR ITPR1 ACSL4 MALRD1 SCN2A SKAP1 RP1 PCDH9	2.64e-07	189	150	8	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR GRM1 ITPR1 ACSL4 MALRD1 SKAP1 RP1 PCDH9	2.98e-07	192	150	8	562df5e87038c500dd3a003fe5374cb31946b145
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR ACSL4 MYOF FGD4 P3H2 SKAP1 RP1 PCDH9	3.10e-07	193	150	8	80e058c224749b5fe0ba3e944b48317c2371cb63
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR ACSL4 MYOF FGD4 P3H2 SKAP1 RP1 PCDH9	3.10e-07	193	150	8	b991fbbb4618401624f0b3045f0e81a606d3a763
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SDK2 ODAD4 ALDH1L1 PALMD FABP4 SRGN EPHA5	3.31e-07	132	150	7	fc79898eeb39c26505cf04df95c3dd75a6593295
ToppCell	Transverse-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	IRAG1 F13A1 PNPT1 MYOF CYP2R1 P3H2 ERCC6L2 C1QTNF4	3.91e-07	199	150	8	fd75dccb37d96448edf72b7d042b06833d4ead24
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE8 SIK1 F13A1 LGALS1 IQGAP1 ITPR1 MYOF	1.16e-06	159	150	7	323cb4a2416d2e6bff0a3f225d2edeae9ab7dc76
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK2 GRIN2B CPS1 SEMA3A CTNNA2 TDRD6 EPHA5	1.21e-06	160	150	7	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK2 GRIN2B CPS1 SEMA3A CTNNA2 TDRD6 EPHA5	1.21e-06	160	150	7	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 GRIK2 IRAG1 PIEZO2 CCNA1 CDH7 PCDH9	1.81e-06	170	150	7	876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 GRIK2 IRAG1 PIEZO2 CCNA1 CDH7 PCDH9	1.81e-06	170	150	7	1f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SDK2 IRS4 SEMA3A MYOF PPP2R1B MCTP2 CDH7	2.37e-06	177	150	7	57033ee0d49a4a50fc25328a4a44d4de2b35f505
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KRT6A ANXA8L1 ANXA8 PCDH20 TRIM7 MYOF CDH7	2.65e-06	180	150	7	535a890bde0d978b461c2d4c571529b585c76b21
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SDK2 ITPR1 ACSL4 MAGI2 GUCA1A SCN2A ATP6V0D2	2.75e-06	181	150	7	e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR LYST IQGAP1 ACSL4 MYOF RP1 PCDH9	2.85e-06	182	150	7	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR CPS1 ACSL4 MYOF SKAP1 RP1 PCDH9	3.07e-06	184	150	7	8fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCell	facs-BAT-Fat-24m-Epithelial-Epcam+\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT6A RAB25 KIF21A ANXA8 MAGI2 P3H2 ATP2C2	3.29e-06	186	150	7	b18d7398279a2d42414318aeb70514fd402f5a0a
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 GRIK2 IRAG1 LGALS1 FABP4 PIEZO2 PCDH9	3.41e-06	187	150	7	ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR GRM1 ITPR1 MALRD1 SKAP1 RP1 PCDH9	3.41e-06	187	150	7	7ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 GRIK2 IRAG1 LGALS1 FABP4 PIEZO2 PCDH9	3.41e-06	187	150	7	d591a3c216997663ab77710fed0d230ffc37e41a
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 GRIK2 IRAG1 LGALS1 FABP4 PIEZO2 PCDH9	3.41e-06	187	150	7	d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR ACSL4 MYOF SCN2A SKAP1 SCN7A DOT1L	3.41e-06	187	150	7	f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR GRM1 ACSL4 MALRD1 SKAP1 RP1 PCDH9	3.54e-06	188	150	7	3cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR ITPR1 ACSL4 SCN2A SKAP1 RP1 PCDH9	3.79e-06	190	150	7	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR MYOF FGD4 P3H2 SKAP1 RP1 PCDH9	3.92e-06	191	150	7	2fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR GRM1 ITPR1 MALRD1 SCN7A RP1 PCDH9	3.92e-06	191	150	7	963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE8 RBP1 SIK1 IRAG1 SCN7A HNRNPA0 TAGLN	3.92e-06	191	150	7	2f733d510a4862565a817f59829d8387d7ea26d9
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE8 RBP1 SIK1 IRAG1 SCN7A HNRNPA0 TAGLN	3.92e-06	191	150	7	8691eba35793e4e90f93d50c2145847ee51289f7
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RBP1 LGALS1 MYOF PIEZO2 P3H2 SCN7A SGCE	4.06e-06	192	150	7	20ede290e01ad574afd122d72b59dbc52c595fad
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DEPTOR RBP1 LGALS1 PIEZO2 P3H2 SCN7A SGCE	4.20e-06	193	150	7	7cd9671e0ac64f7f3607f564485c63abbb7e7a63
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR SYNE1 MYOF FGD4 P3H2 SKAP1 RP1	4.20e-06	193	150	7	42df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR SYNE1 MYOF FGD4 P3H2 SKAP1 RP1	4.20e-06	193	150	7	f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR MYOF FGD4 P3H2 SKAP1 RP1 PCDH9	4.20e-06	193	150	7	263d185af6ed80e639f864e4966268e0862c61dc
ToppCell	Control-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	SDK2 ITPR1 PIEZO2 FGD4 SRGN SCN7A MCTP2	4.20e-06	193	150	7	5896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SDK2 RBP1 LGALS1 MYOF PIEZO2 SCN7A PCDH9	4.35e-06	194	150	7	5f5f0cdeacd5e1b28717d78dabdb9eb95f661e36
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	RBP1 LGALS1 SEMA3A MAGI2 PIEZO2 SCN7A PCDH9	4.35e-06	194	150	7	a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCell	COVID-19-kidney-TAL\|kidney / Disease (COVID-19 only), tissue and cell type	DEPTOR ACSL4 MYOF FGD4 SKAP1 RP1 PCDH9	4.65e-06	196	150	7	04f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SYNE1 FABP4 SEMA3A PIEZO2 SUMF1 PALM SGCE	4.65e-06	196	150	7	a31e227de2dc077b81881295b012d22fedbd65ed
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SYNE1 FABP4 SEMA3A PIEZO2 SUMF1 PALM SGCE	4.65e-06	196	150	7	b04ca69b0ed44e09c989b575f747e1e819cd8008
ToppCell	Severe-Plasmablast\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CCPG1 PDK1 LGALS1 ALDH1L2 SRGN PDIA5 SEC63	4.81e-06	197	150	7	1089aa7991812378668d0f3d57f8000e6245a713
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CPNE8 SDK2 ADAMTS3 KIF21A F13A1 PIEZO2 PCDH9	4.81e-06	197	150	7	6e111ba16fc8adde782b3f7da250248cddf11228
ToppCell	Macroglial-Astrocytes-SLC14A1---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SYNE1 ALDH1L1 IRAG1 FGD4 NBPF10 PALM CTNNA2	5.31e-06	200	150	7	d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Cortical_neuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	ADAMTS3 SYNE1 SPTAN1 ACSL4 SCN2A CTNNA2 EPHA5	5.31e-06	200	150	7	44bc4d6616fc8d0ad8498e56125939034e8cff01
ToppCell	Brain_organoid-organoid_Tanaka_cellReport\|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.	RBP1 SIK1 LGALS1 IQGAP1 MYOF NBPF10 TAGLN	5.31e-06	200	150	7	b0ba486b55be18a4236bd2644f02352651f4b1fe
ToppCell	Macroglial-Astrocytes-SLC14A1----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SYNE1 ALDH1L1 IRAG1 FGD4 NBPF10 PALM CTNNA2	5.31e-06	200	150	7	f861509b54185d89931db64da1b9d81986cc7938
ToppCell	Macroglial-Astrocytes-SLC14A1\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SYNE1 ALDH1L1 IRAG1 FGD4 NBPF10 PALM CTNNA2	5.31e-06	200	150	7	16f468217427921fa18c6d078ffa990eb019b257
ToppCell	Macroglial-Astrocytes-SLC14A1--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SYNE1 ALDH1L1 IRAG1 FGD4 NBPF10 PALM CTNNA2	5.31e-06	200	150	7	0442894c39eec69850c090957a5dc7bcecd21e04
ToppCell	Macroglial-Astrocytes-SLC14A1-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SYNE1 ALDH1L1 IRAG1 FGD4 NBPF10 PALM CTNNA2	5.31e-06	200	150	7	01819446deeab9054f5cfe889d53bb49d137dbc0
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IRS4 GRIN2B PALMD FAM187A FABP4 RP1	1.61e-05	158	150	6	78b48b110b777bcc4c07cd23388bee911c0231d6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 GRIK2 IRAG1 PIEZO2 CCNA1 PCDH9	1.67e-05	159	150	6	5ca96db4281abb5f646150ccf36adc66ab201c78
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR LYST IQGAP1 SCN2A CTNNA2 PCDH9	1.85e-05	162	150	6	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	normal-na-Lymphocytic_NK-NK_bright-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	SYNE1 KIF21A TEC MAGI2 SRGN MCTP2	1.98e-05	164	150	6	b5a91f2cbfad9a2bc38aea576085a37865df955d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SDK2 PALMD SEMA3A MYOF ATP2C2 MCTP2	2.43e-05	170	150	6	021c3e45955d18e241f7d98acdf22076fee4fc43
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 GRIK2 IRAG1 PIEZO2 CDH7 PCDH9	2.59e-05	172	150	6	08a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KRT6A ANXA8L1 RBP1 ANXA8 MYOF CDH7	2.59e-05	172	150	6	e9095c3dac66cf93d31f5f88364b565abacb1e2d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 GRIK2 IRAG1 PIEZO2 CDH7 PCDH9	2.59e-05	172	150	6	553701349444eb366df3c11f54bb093434f153c6
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SDK2 SEMA3A MYOF ATP2C2 MCTP2 EPHA5	2.77e-05	174	150	6	e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_AB\|TCGA-Thymus / Sample_Type by Project: Shred V9	P3H2 SCN7A CCNA1 PALM SGCE C1QTNF4	2.86e-05	175	150	6	50f9b994bdd389158f92f891944ea81b2fb15eef
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FABP4 PIEZO2 TAGLN CDH7 PCDH9	2.86e-05	175	150	6	1b4cefae400bf756d09ece32d3f5c0bd4c6ad73f
ToppCell	3'_v3-blood-Mast-Mast_cell_granulo-myelo\|blood / Manually curated celltypes from each tissue	SLC2A8 MAGI2 CCNA1 PLD1 SMAD4 PCYT1B	2.95e-05	176	150	6	d421b6b8e13894dbcf29548c0a6516c3dee8f9b1
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPNE8 SDK2 SEMA3A ATP2C2 MCTP2 EPHA5	3.05e-05	177	150	6	4c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell	facs-BAT-Fat-24m\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT6A RAB25 KIF21A ANXA8 FABP9 CKMT2	3.35e-05	180	150	6	3d4a7fbd407d4433bd7d525f785312e90f9a5eb8
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYNE1 NT5C3A TEC IRAG1 LYST SRGN	3.35e-05	180	150	6	4e9e8cde2919610c4ac0025b1c9819808048bc1d
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYNE1 NT5C3A TEC IRAG1 LYST SRGN	3.35e-05	180	150	6	ca2a35bfb67347e47f511589a3d0f763e6664634
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYNE1 NT5C3A TEC IRAG1 LYST SRGN	3.35e-05	180	150	6	466381bf93c3da6a2a241daadb68e9aad2964eae
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FABP4 PIEZO2 TAGLN CDH7 PCDH9	3.45e-05	181	150	6	a2058d658f07ab6f0a28d2622f3090b4cde6f763
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FABP4 PIEZO2 TAGLN CDH7 PCDH9	3.45e-05	181	150	6	526e858a848470b6d2d5248788004d9735ed3add
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITPR1 ACSL4 CKMT2 SCN2A SCN7A MAP3K15	3.56e-05	182	150	6	5f513bbb7125956eb528e3120de3fd776770a7c3
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DEPTOR ALDH1L1 SLC13A1 P3H2 SCN2A SKAP1	3.56e-05	182	150	6	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	Control-Epithelial_alveolar-AT_2-AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAB25 DEPTOR KIF21A ACSL4 P3H2 PDIA5	3.56e-05	182	150	6	e97681a4102f3095d5d9e90ad70f1dc46e90983a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ITPR1 ACSL4 CKMT2 SCN2A SCN7A NNT	3.67e-05	183	150	6	2f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCell	facs-Lung-24m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l14\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KRT6A RAB25 NT5C3A ANXA8 FABP4 ERCC6L2	3.67e-05	183	150	6	6e5b39c0170d62eb7fdd411dcfff51ed176573d0
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIN2B CPS1 GRM1 PIEZO2 SCN2A EPHA5	3.79e-05	184	150	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	Control-Epithelial_alveolar-AT_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAB25 DEPTOR KIF21A ACSL4 P3H2 PDIA5	3.79e-05	184	150	6	51e129b3fcc2df083eda05a3afe3717218b1e52b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR ACSL4 FGD4 SKAP1 RP1 PCDH9	3.79e-05	184	150	6	d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIN2B CPS1 GRM1 PIEZO2 SCN2A EPHA5	3.79e-05	184	150	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIN2B CPS1 GRM1 PIEZO2 SCN2A EPHA5	3.79e-05	184	150	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAB25 DEPTOR KIF21A ACSL4 P3H2 PDIA5	3.90e-05	185	150	6	fefaf227d89f680d6f3e91c4a94e26ab4d0dc6c3
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRAG1 LGALS1 MYOF DLG3 TAGLN DOT1L	3.90e-05	185	150	6	38486b69c48dc5e1c4e1488208fa8954a973eccb
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRAG1 LGALS1 MYOF DLG3 TAGLN DOT1L	3.90e-05	185	150	6	3c28b5ceba3cfdb6f7e32d5b42e03b6a81a7a658
ToppCell	(4)_Lymph_vessel\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	GRIN2B FABP4 SEMA3A PIEZO2 PALM SGCE	4.02e-05	186	150	6	6b3afc2ae870ff73e30a60ce84fcee0eb365d809
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ALDH1L1 ITPR1 MALRD1 FGD4 RP1 PCDH9	4.14e-05	187	150	6	b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR MYOF FGD4 SKAP1 RP1 PCDH9	4.14e-05	187	150	6	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR MYOF FGD4 SKAP1 RP1 PCDH9	4.14e-05	187	150	6	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 GRIK2 IRAG1 PIEZO2 CDH7 PCDH9	4.14e-05	187	150	6	15d6e158562d7d85af3ceaf955439b379c8fce81
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 GRIK2 IRAG1 PIEZO2 CDH7 PCDH9	4.14e-05	187	150	6	f62074b631fd45ad299c69d71b09267b04d656ee
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR MYOF FGD4 SKAP1 RP1 PCDH9	4.14e-05	187	150	6	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	COVID-19-kidney-Mito-rich_Distal\|kidney / Disease (COVID-19 only), tissue and cell type	DEPTOR ACSL4 FGD4 SKAP1 RP1 PCDH9	4.14e-05	187	150	6	2ce8038d9d1302e850c1bb536e755598f77ba4b9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR LYST ACSL4 MYOF SCN2A SKAP1	4.14e-05	187	150	6	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DEPTOR ALDH1L1 SLC13A1 P3H2 SCN2A SKAP1	4.14e-05	187	150	6	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 GRIK2 IRAG1 PIEZO2 CDH7 PCDH9	4.27e-05	188	150	6	32f22a4d8cb98fd8b8fa0fbf28ef9266d711d081
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	IQGAP1 ITPR1 MYOF P3H2 ATP2C2 MCTP2	4.27e-05	188	150	6	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBP1 LYST SEMA3A ZFHX2 PALM PDIA5	4.40e-05	189	150	6	8e583ec4df0f5b79ce5211cc99ecd8616d180bde
Disease	West Syndrome	SPTAN1 SIK1 GRIN2B MAGI2 GUF1 SCN2A	1.40e-09	24	142	6	C0037769
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN2A SCN7A	1.28e-05	10	142	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN2A SCN7A	1.28e-05	10	142	3	DOID:0080422 (implicated_via_orthology)
Disease	fibrinogen measurement	GRIK2 CPS1 ITPR1 PDIA5 TTC17 PLEC	1.51e-05	109	142	6	EFO_0004623
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN2A SCN7A	2.33e-05	12	142	3	DOID:0060170 (implicated_via_orthology)
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN2A TNRC6A	3.01e-05	13	142	3	C0751122
Disease	Early infantile epileptic encephalopathy with suppression bursts	SIK1 SCN1A SCN2A	5.84e-05	16	142	3	C0393706
Disease	cystathionine measurement	TEC CTNNA2 TEC	9.99e-05	19	142	3	EFO_0010474
Disease	Schwannomatosis	COQ6 SMARCB1	1.37e-04	4	142	2	C1335929
Disease	Neurofibromatosis, Type 3, mixed central and peripheral	COQ6 SMARCB1	1.37e-04	4	142	2	C2931480
Disease	tyrosine-protein kinase TEC measurement	TEC TEC	1.37e-04	4	142	2	EFO_0020830
Disease	Colorectal Carcinoma	IRS4 ATP7B SYNE1 ALDH1L1 GRM1 ACSL4 PPP2R1B MLH1 DLG3 SNRNP200 CDH7 SMAD4	1.56e-04	702	142	12	C0009402
Disease	Malignant neoplasm of breast	ATG10 ATP7B SYNE1 SPTAN1 GRIK2 HELQ PABPC1 PCDH20 FABP4 SEMA3A CDH20 FBXO8 P3H2 ANKEF1 ANAPC5	2.17e-04	1074	142	15	C0006142
Disease	Neurofibromatosis 3	COQ6 SMARCB1	2.28e-04	5	142	2	C0917817
Disease	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1	SIK1 SCN1A	3.41e-04	6	142	2	C3463992
Disease	neuroticism measurement, cognitive function measurement	KIF27 PCDHA3 DENND1A SCN2A YLPM1 TNRC6A CCNA1 PALM CDH7 PCDH9	4.31e-04	566	142	10	EFO_0007660, EFO_0008354
Disease	Seizure, Febrile, Simple	SCN1A SCN2A	4.75e-04	7	142	2	C0149886
Disease	Seizure, Febrile, Complex	SCN1A SCN2A	4.75e-04	7	142	2	C0751057
Disease	Adenocarcinoma of lung (disorder)	MSH3 ACSL4 MLH1 MAP3K15 DOT1L EPHA5	5.01e-04	206	142	6	C0152013
Disease	Bipolar Disorder	PDE9A SYNE1 GRIK2 GRIN2B ITPR1 MAGI2 SCN2A DLG3 CDH7	5.25e-04	477	142	9	C0005586
Disease	Early Childhood Epilepsy, Myoclonic	SCN1A TNRC6A	6.32e-04	8	142	2	C0393695
Disease	Idiopathic Myoclonic Epilepsy	SCN1A TNRC6A	6.32e-04	8	142	2	C0338478
Disease	Symptomatic Myoclonic Epilepsy	SCN1A TNRC6A	6.32e-04	8	142	2	C0338479
Disease	X-linked infantile spasms	SIK1 SCN1A	6.32e-04	8	142	2	C4552072
Disease	Benign Infantile Myoclonic Epilepsy	SCN1A TNRC6A	6.32e-04	8	142	2	C0751120
Disease	Myoclonic Encephalopathy	SCN1A TNRC6A	6.32e-04	8	142	2	C0438414
Disease	Myoclonic Absence Epilepsy	SCN1A TNRC6A	6.32e-04	8	142	2	C0393703
Disease	Epilepsy, Cryptogenic	GRIN2B GRM1 SCN1A SCN2A	6.72e-04	82	142	4	C0086237
Disease	Awakening Epilepsy	GRIN2B GRM1 SCN1A SCN2A	6.72e-04	82	142	4	C0751111
Disease	Aura	GRIN2B GRM1 SCN1A SCN2A	6.72e-04	82	142	4	C0236018
Disease	response to anticonvulsant	F13A1 MAGI2 SUMF1 ATP6V0D2	7.70e-04	85	142	4	GO_0036277
Disease	Febrile Convulsions	SCN1A SCN2A	8.10e-04	9	142	2	C0009952
Disease	Myoclonic Epilepsy	SCN1A TNRC6A	8.10e-04	9	142	2	C0014550
Disease	non-syndromic X-linked intellectual disability (implicated_via_orthology)	ACSL4 DLG3	8.10e-04	9	142	2	DOID:0050776 (implicated_via_orthology)
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN2A	8.10e-04	9	142	2	C3502809
Disease	myositis	SDK2 TEC TEC	8.78e-04	39	142	3	EFO_0000783
Disease	Epilepsy, Myoclonic, Infantile	SCN1A TNRC6A	1.01e-03	10	142	2	C0917800
Disease	Neurodevelopmental Disorders	GRIN2B ITPR1 SCN1A SCN2A	1.08e-03	93	142	4	C1535926
Disease	epilepsy (implicated_via_orthology)	GRIN2B SLC13A1 SCN1A SCN2A SCN7A	1.18e-03	163	142	5	DOID:1826 (implicated_via_orthology)
Disease	Schizophrenia	ADAMTS3 RBP1 GRIK2 GRIN2B GRM1 SEMA3A MAGI2 SETDB1 DLG3 OXSR1 CTNNA2 MCTP2	1.19e-03	883	142	12	C0036341
Disease	risk-taking behaviour	ABI1 ATG10 MSH3 GRIN2B DENND1A MAGI2 SUMF1 TNRC6A C1QTNF4 CTNNA2 EPHA5	1.21e-03	764	142	11	EFO_0008579
Disease	Myoclonic Astatic Epilepsy	SCN1A TNRC6A	1.23e-03	11	142	2	C0393702
Disease	endometrial carcinoma (is_implicated_in)	MSH3 SMAD4	1.47e-03	12	142	2	DOID:2871 (is_implicated_in)
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	ZMPSTE24 SYNE1	1.47e-03	12	142	2	DOID:11726 (implicated_via_orthology)
Disease	Abnormality of refraction	RPGRIP1 PCDHA3 GRIN2B DCTN1 SEMA3A MAGI2 SUMF1 SCN2A CTNNA2 PCDH9	1.60e-03	673	142	10	HP_0000539
Disease	Unipolar Depression	ATP7B GRM1 ACSL4 DLG3 MCTP2 CDH7	1.63e-03	259	142	6	C0041696
Disease	Mental Retardation, X-Linked Nonsyndromic	ACSL4 DLG3	1.73e-03	13	142	2	C3501611
Disease	Epilepsy	GRIN2B GRM1 SCN1A SCN2A	1.93e-03	109	142	4	C0014544
Disease	N-acetylglycine measurement	ALDH1L1 CPS1	2.01e-03	14	142	2	EFO_0021002
Disease	Metastatic melanoma	SIK1 MAP3K15 OXSR1	2.26e-03	54	142	3	C0278883
Disease	MMR-related febrile seizures	SCN1A SCN2A	2.32e-03	15	142	2	EFO_0006519
Disease	cortex volume change measurement	MAGI2 SUMF1	2.32e-03	15	142	2	EFO_0021500
Disease	Ischemic stroke, fibrinogen measurement	CPS1 TTC17 PLEC	2.38e-03	55	142	3	EFO_0004623, HP_0002140
Disease	cleft lip	PDE9A SYNE1 SLC13A1 P3H2 SUMF1 ERCC6L2	2.59e-03	284	142	6	EFO_0003959
Disease	nervousness	DENND1A YLPM1	2.64e-03	16	142	2	NCIT_C74532
Disease	cathepsin L1 measurement	GRM1 PIK3R2	2.64e-03	16	142	2	EFO_0010619
Disease	abdominal fat cell number	RAB35 TEC SCN7A CTNNA2 TEC	2.76e-03	198	142	5	EFO_0021534
Disease	fibrinogen measurement, factor VII measurement	CPS1 TTC17 PLEC	2.77e-03	58	142	3	EFO_0004619, EFO_0004623
Disease	cortical thickness	ADAMTS3 MSH3 IRAG1 CMAS DENND1A SEMA3A MALRD1 CDH20 G3BP1 CSK YLPM1 TNRC6A PLEC	2.86e-03	1113	142	13	EFO_0004840
Disease	colon cancer (is_marker_for)	PIK3R2 MLH1 SMAD4	2.91e-03	59	142	3	DOID:219 (is_marker_for)
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN1A SCN2A	3.35e-03	18	142	2	HP_0002373
Disease	Malignant neoplasm of endometrium	PIK3R2 MLH1	3.35e-03	18	142	2	C0007103
Disease	alpha synuclein measurement	PNPT1 OXSR1	3.35e-03	18	142	2	EFO_0009323
Disease	Carcinoma in situ of endometrium	PIK3R2 MLH1	3.35e-03	18	142	2	C0346191
Disease	thrombin activatable fibrinolysis inhibitor activation peptide measurement	DENND1A ITPR1	3.73e-03	19	142	2	EFO_0008582
Disease	Cannabis use, age at onset	CDH20 ATP2C2	3.73e-03	19	142	2	EFO_0004847, EFO_0007585
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	MSH3 MLH1	3.73e-03	19	142	2	C1333991
Disease	ovarian neoplasm	ATP7B GRIK2 SKAP1 MLH1	4.07e-03	134	142	4	C0919267
Disease	Liver Cirrhosis, Experimental	SPTAN1 ALDH1L1 PALMD CPS1 LGALS1 IQGAP1 LIMK2 ALDH1L2 SRGN SMAD4	4.35e-03	774	142	10	C0023893
Disease	Malignant neoplasm of ovary	ATP7B GRIK2 SKAP1 MLH1	4.40e-03	137	142	4	C1140680
Disease	quinolinic acid measurement	CPS1 CDH7	4.55e-03	21	142	2	EFO_0010528
Disease	Vertigo	SDK2 ABI1 MALRD1 DROSHA	4.64e-03	139	142	4	HP_0002321

Protein segments in the cluster

Peptide	Gene	Start	Entry
ESDVMLKEGYENFFD	NT5C3A	176	Q9H0P0
QDEDMDVKYFAQEAI	PPP2R1B	581	P30154
ISMGYFKNEEKTAED	ACSL4	526	O60488
AGEMVFVYENAKEGA	BTBD10	146	Q9BSF8
EEQQDDTVYMGKVTF	DCTN1	1236	Q14203
IQDLGFEAAVMEDYA	ATP7B	546	P35670
NEDVYMATKFEGFIQ	ALDH1L2	396	Q3SY69
EMTNQDVIKAVEEGY	EPHA5	881	P54756
MAVTFDKVYVNIGGD	C1QTNF4	46	Q9BXJ3
FDKDNLDDMGYIVEN	COQ6	131	Q9Y2Z9
KDDELSFMEGAIIYV	ABI1	461	Q8IZP0
DMTIVDNEGKGVLFY	ANKEF1	106	Q9NU02
KVMEGTVAAQDEFYR	CSK	171	P41240
IFKGRSYEEDMEIAE	AQR	981	O60306
MEEDEFIGEKTFQRY	ATG10	1	Q9H0Y0
YDVDIQNSEGMVATF	FAM187A	136	A6NFU0
YGETSFDLVAQMIDE	DOT1L	136	Q8TEK3
KEYKGVFEMFDEEGN	CALML6	36	Q8TD86
EDQEDIYFMKGALEE	ATP2C2	501	O75185
LYGKVDFTEEEINNM	IQGAP1	171	P46940
MGNGTEEDYNFVFKV	RAB25	1	P57735
IFMGYQNVEDEAETK	PALM	301	O75781
ETEDAYKFAGQMGIQ	RAB35	131	Q15286
YEDAGYQTAELVKMD	GUF1	541	Q8N442
TDGAVYAMEINVEKD	PALM2	131	Q8IXS6
IFMGYQNIEDEEETK	PALM2	281	Q8IXS6
TNVYIKNFGEDMDDE	PABPC1	191	P11940
EVMEQVRGYDFKADI	OXSR1	196	O95747
MAQGVIEYKESFGVD	PDK1	156	Q15118
YFQNGEKKTVEDADM	ANAPC5	161	Q9UJX4
IMKAYEEDYGSSLEE	ANXA8	131	P13928
KYVGTMEASEDAAFN	ANKRD27	226	Q96NW4
AADNIYKGQSTFMEE	MSH3	941	P20585
IFMGYQQAEDSEEDK	PALMD	416	Q9NP74
EVYAVDKDTGMNAVI	PCDH20	766	Q8N6Y1
EGVNKDIAYSFNTDM	PCDHA3	271	Q9Y5H8
DLEQAFKGVIYLEMD	MCTP2	611	Q6DN12
ENVEVVFGLYLKEMD	MAGEB17	156	A8MXT2
QDFDYFTVDMEKGAK	MAGI2	1141	Q86UL8
EAINYMAADGDFKIK	LGALS1	116	P09382
MAELVNSGEDVLVFY	ITPR1	1341	Q14643
GMQDLVEDFKNKYED	KRT6A	241	P02538
EMLNGKSYDETVDIF	LIMK2	516	P53671
ETKARMEEEAYSKGF	IRAG1	766	Q9Y6F6
EQDGEGIMETFKTYE	KIF27	1186	Q86VH2
FKGFTVMNEAERYEA	PCYT1B	121	Q9Y5K3
FAVDVDTGMNAELKY	PCDH9	701	Q9HC56
LEEYFMQSDREKSEG	PDE9A	481	O76083
EYVKGFDNAMELVKN	FGD4	301	Q96M96
MDENSIFDNGLYDEK	NRDE2	661	Q9H7Z3
DEGVNYFMSKGILDD	FBXO8	151	Q9NRD0
MDITDTYKFQEGQEE	F13A1	476	P00488
AGVKHYEADDFEMAI	P3H2	216	Q8IVL5
KNMELNVYGDDVEVD	PIGK	106	Q92643
GVAYQALTEAVMFDD	ALPI	341	P09923
GIKNETEDQYALMED	PIK3R2	596	O00459
VFEGQMASTYEQDEV	MALRD1	201	Q5VYJ5
EERVYMVGKANSVFE	ATP6AP2	131	O75787
FDYSGSQAVKAMKEE	CPS1	441	P31327
DGLAGMIKSDNEEYF	ADAMTS3	166	O15072
MKEYEVDNDGVFEKL	CCPG1	711	Q9ULG6
IMKAYEEDYGSSLEE	ANXA8L1	131	Q5VT79
AEMENYEAGVYTEKV	CTNNA2	556	P26232
IKTADRQYMEGFNDE	CDC37	241	Q16543
NAEMKYTIVDGDGAD	CDH20	306	Q9HBT6
FVDAYLDEMDQGKND	CYP2R1	276	Q6VVX0
GTFYDQAVVSNDMEE	G3BP1	171	Q13283
MEDYQAAEETAFVVD	DYNLT1	1	P63172
MAFEDVYEVDTGTLK	CCNA1	156	P78396
EEGVKYERTFMASEF	DEPTOR	156	Q8TB45
NGSDGMFKYEEIVLE	DLG3	121	Q92796
YMNENGEFKLDVDSN	LYST	1891	Q99698
VEQMFETFDFNKDGY	GUCA1A	56	P43080
FSDVFEEEINMGEYA	DENND1A	381	Q8TEH3
ELSLNEDAYMGVVDE	IZUMO1	66	Q8IYV9
EDAYMGVVDEATLQK	IZUMO1	71	Q8IYV9
LVSSENFDDYMKEVG	FABP4	11	P15090
NFDDYMKEVGVGFAT	FABP4	16	P15090
IGANAEMEYKIVDGD	CDH7	291	Q9ULB5
YESMDKFLDGVQEVA	ERCC6L2	1116	Q5T890
NDTIYEVDSKAENGM	HELQ	531	Q8TDG4
AEEDALQMAVGYFEK	CENPI	61	Q92674
EYGAVEDGATMTFFK	GRIK2	681	Q13002
EENYVQDSKMGFVIN	GRM1	401	Q13255
EYSVLNKDIQEDSGM	ZMPSTE24	286	O75844
AEAEVEATQMTYFNG	SLC13A1	161	Q9BZW2
EVQVAYMGSFEEGEK	SDK2	106	Q58EX2
LVSSENFEDYMKELG	FABP9	11	Q0Z7S8
NFEDYMKELGVNFAA	FABP9	16	Q0Z7S8
DLIYGQFVVANKDME	EXOSC3	161	Q9NQT5
AVGEIVQDYDSDKMF	CPNE8	346	Q86YQ8
AGMNVYSSEFENIKE	PDIA5	206	Q14554
VGMVAGDEESYEVFA	CKMT2	106	P17540
QEKMIGQFSYSEERE	RP1	476	P56715
EEEGDYIEVIFNSAM	IRS4	1011	O14654
DSQEIDKFMALVYAG	OR13F1	266	Q8NGS4
AFYDADVAVVDMSDV	MAP3K15	116	Q6ZN16
GGYAKEMSKEFIEAE	NNT	286	Q13423
AEELGMQEYAITNDK	DROSHA	1191	Q9NRR4
AFYPEAEVMSDENIK	RPGRIP1	1126	Q96KN7
FVDYGDREMVSVKNI	TDRD6	851	O60522
GVIDFSMYLKNEEDI	RUFY2	176	Q8WXA3
TAEMYVKADGSVEEA	SYNE1	566	Q8NF91
EEIVVAMYDFQAAEG	TEC	181	P42680
RVGFAFDMDEIEKYQ	NBPF10	911	Q6P3W6
VGFAVDMDEIEKYQE	NBPF10	1156	Q6P3W6
GFAVDMDEIEKYQEV	NBPF10	1401	Q6P3W6
KVAEMIREEGYDSVF	CMAS	156	Q8NFW8
VNAKGYFEDVANAME	PLD1	356	Q13393
YIMDFQVGKEFEEDL	RBP1	61	P09455
QKAETLYTMGDFEFA	ODAD4	86	Q96NG3
VEYTHDKDTDMFQVG	PELI2	91	Q9HAT8
GVNAVMFYAETIFEE	SLC2A8	271	Q9NY64
IAYFEMDVQVGETFK	SMAD4	326	Q13485
IVTEFAKNGEMFDYL	SIK1B	101	A0A0B4J2F2
IVTEFAKNGEMFDYL	SIK1	101	P57059
KFQLEDDGEFYMIGS	SMARCB1	16	Q12824
KGVFLENYMDFELDI	NLRP7	626	Q8WX94
MEQVAQFLKAAEDYG	TAGLN	91	Q01995
VDRVDAEDGQYDVMF	SEMA3A	436	Q14563
AEDGQYDVMFIGTDV	SEMA3A	441	Q14563
MLADYFSLEIDEEGN	MLH1	621	P40692
TDILGIEDYNGDMDF	PNPT1	531	Q8TCS8
IEDYNGDMDFKIAGT	PNPT1	536	Q8TCS8
NDLKEGVYVMVGADV	SGCE	216	O43556
MDAYEVSNTEFEKFV	SUMF1	126	Q8NBK3
NFEGYMKALDIDFAT	RBP2	16	P50120
FADKEGLEMGDEYFA	SETDB1	841	Q15047
NFAYVKREVGIDDMF	SCN1A	1691	P35498
EFNDVYQEVKGSMND	SSRP1	6	Q08945
EGECSIDYVEMAVNK	ALDH1L1	401	O75891
VEVDTFMEAYDQKIA	RRP7A	171	Q9Y3A4
GMSADKNFYLEEEDK	DNTTIP2	496	Q5QJE6
DMLDKEISQFVSEGY	SWI5	171	Q1ZZU3
DLEVGAVSFYAVEDM	TRIM7	466	Q9C029
EENSQIYKFLLDMEG	ZFHX2	846	Q9C0A1
GFVTYSNVEEADAAM	HNRNPA0	51	Q13151
YTMGTGFDVNIVEEE	KIF21A	96	Q7Z4S6
INEKMTLVASEDYGD	SPTAN1	1886	Q13813
GFLTEMEQDYQLVDE	SRGN	111	P10124
NFAYVKREVGIDDMF	SCN2A	1681	Q99250
GAMQFLENYEKEDIT	PIEZO2	2481	Q9H5I5
NEAKGFEIMYDSDVL	ZDBF2	1236	Q9HCK1
FLEDEKYEEVMAVLG	SEC63	426	Q9UGP8
LTDQQQFGKADEMYD	TOMM70	486	O94826
EVAYKRGLFDEEMNE	PLEC	4201	Q15149
FTELQEKYGEIEEMN	U2AF1L4	86	Q8WU68
LGNVYVAMEEFEKAL	TTC17	1091	Q96AE7
KGFEVYLAEMSADNQ	YLPM1	1951	P49750
NMDGTINVDDFKIIY	SNRNP200	526	O75643
ISEEEEMFYGGERSK	SCN7A	881	Q01118
MSGIDTDKVNNYIED	VPS33A	381	Q96AX1
LYEFAKMGEEESQFL	USP34	2446	Q70CQ2
FLSDYQDEGMEDIVK	SKAP1	86	Q86WV1
YFDKDGIVADESQNM	TNRC6A	1276	Q8NDV7
GKTLEDVFYEREVQM	ATP6V0D2	286	Q8N8Y2
SDTYMVFGEAKIEDL	NACA4P	116	Q9BZK3
LMGEFKIDVGFVYDE	MYOF	276	Q9NZM1
AAFMIQEEYVDQVSG	GRIN2B	651	Q13224