Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glycosylceramide flippase activity	ATP10B ATP10D	9.32e-05	3	112	2	GO:0140351
GeneOntologyCellularComponent	synaptic membrane	HTR1B HCN1 CYTH2 CYTH1 HTR3E HTR3C CNKSR2 GRIN1 KCNA2 PTPRD TENM3 IGSF9B CTNNB1	1.33e-05	583	111	13	GO:0097060
GeneOntologyCellularComponent	cell-cell junction	ILDR2 CYTH2 CYTH1 GJC1 APC EVPL KCNA2 PTPRM LMO7 PIK3R1 TLN1 CTNNB1 CTNND2	1.54e-05	591	111	13	GO:0005911
GeneOntologyCellularComponent	adherens junction	CYTH2 CYTH1 APC PTPRM LMO7 TLN1 CTNNB1 CTNND2	1.77e-05	212	111	8	GO:0005912
GeneOntologyCellularComponent	anchoring junction	ILDR2 CYTH2 CYTH1 GJC1 APC EVPL CYFIP1 KCNA2 PTPRM LMO7 PIK3R1 TLN1 SYNE2 CTNNB1 CTNND2 SNTB1	5.70e-05	976	111	16	GO:0070161
GeneOntologyCellularComponent	cell leading edge	MYO1D HCN1 CYTH2 APC GRIN1 CYFIP1 KCNA2 PTPRM TLN1 SYNE2 CTNNB1	7.22e-05	500	111	11	GO:0031252
GeneOntologyCellularComponent	Scrib-APC-beta-catenin complex	APC CTNNB1	8.35e-05	3	111	2	GO:0034750
GeneOntologyCellularComponent	presynaptic membrane	HTR1B HCN1 CYTH1 GRIN1 KCNA2 PTPRD TENM3 CTNNB1	1.17e-04	277	111	8	GO:0042734
GeneOntologyCellularComponent	leading edge membrane	MYO1D HCN1 APC GRIN1 KCNA2 TLN1 SYNE2	1.31e-04	210	111	7	GO:0031256
GeneOntologyCellularComponent	serotonin-activated cation-selective channel complex	HTR3E HTR3C	2.77e-04	5	111	2	GO:1904602
GeneOntologyCellularComponent	serotonin receptor complex	HTR3E HTR3C	2.77e-04	5	111	2	GO:0098665
GeneOntologyCellularComponent	postsynaptic membrane	HCN1 CYTH2 HTR3E HTR3C CNKSR2 GRIN1 KCNA2 IGSF9B CTNNB1	3.12e-04	405	111	9	GO:0045211
GeneOntologyCellularComponent	cell projection membrane	MYO1D HCN1 SLC38A4 APC GRIN1 KCNA2 TLN1 SYNE2 CTNNB1	4.90e-04	431	111	9	GO:0031253
GeneOntologyCellularComponent	dendrite	HTR1B MYO1D HCN1 APC GRIN1 CYFIP1 KCNA2 ABHD13 IGSF9B CTNNB1 CTNND2 MLPH KIF1C	6.28e-04	858	111	13	GO:0030425
GeneOntologyCellularComponent	dendritic tree	HTR1B MYO1D HCN1 APC GRIN1 CYFIP1 KCNA2 ABHD13 IGSF9B CTNNB1 CTNND2 MLPH KIF1C	6.42e-04	860	111	13	GO:0097447
GeneOntologyCellularComponent	bicellular tight junction	ILDR2 CYTH2 CYTH1 APC CTNNB1	6.75e-04	131	111	5	GO:0005923
GeneOntologyCellularComponent	extrinsic component of plasma membrane	CYTH2 CYTH1 APC CNKSR2 CTNNB1	8.26e-04	137	111	5	GO:0019897
GeneOntologyCellularComponent	extrinsic component of synaptic membrane	CYTH2 CYTH1 CNKSR2	8.43e-04	35	111	3	GO:0099243
GeneOntologyCellularComponent	tight junction	ILDR2 CYTH2 CYTH1 APC CTNNB1	8.82e-04	139	111	5	GO:0070160
GeneOntologyCellularComponent	postsynapse	RPL36 HCN1 CYTH2 HTR3E APC HTR3C CNKSR2 GRIN1 CYFIP1 KCNA2 PLCB1 IGSF9B CTNNB1 CTNND2	9.93e-04	1018	111	14	GO:0098794
GeneOntologyCellularComponent	endoplasmic reticulum membrane	ILDR2 UBE2J1 GJC1 SRP9 CASQ1 ATP10B GRIN1 SPPL2B SEC22A ATP10D ADGRG6 BCAP31 KCNA2 PIK3R1 SYNE2 OTULINL	1.31e-03	1293	111	16	GO:0005789
GeneOntologyCellularComponent	glutamatergic synapse	HCN1 CYTH2 ADGRB2 APC CNKSR2 GRIN1 KCNA2 PTPRD TENM3 PLCB1 CTNNB1 CTNND2	1.33e-03	817	111	12	GO:0098978
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	ILDR2 UBE2J1 GJC1 SRP9 CASQ1 ATP10B GRIN1 SPPL2B SEC22A ATP10D ADGRG6 BCAP31 KCNA2 PIK3R1 SYNE2 OTULINL	1.37e-03	1299	111	16	GO:0098827
GeneOntologyCellularComponent	lamellipodium	APC CYFIP1 KCNA2 PTPRM SYNE2 CTNNB1	1.44e-03	230	111	6	GO:0030027
GeneOntologyCellularComponent	extrinsic component of membrane	CYTH2 CYTH1 APC CNKSR2 PIK3R1 CTNNB1	1.44e-03	230	111	6	GO:0019898
GeneOntologyCellularComponent	neuron projection terminus	HTR1B HCN1 APC GRIN1 CYFIP1 KCNA2	1.54e-03	233	111	6	GO:0044306
GeneOntologyCellularComponent	apical junction complex	ILDR2 CYTH2 CYTH1 APC CTNNB1	1.56e-03	158	111	5	GO:0043296
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	ILDR2 UBE2J1 GJC1 SRP9 CASQ1 ATP10B GRIN1 SPPL2B SEC22A ATP10D ADGRG6 BCAP31 KCNA2 PIK3R1 SYNE2 OTULINL	1.71e-03	1327	111	16	GO:0042175
GeneOntologyCellularComponent	extrinsic component of postsynaptic specialization membrane	CYTH2 CNKSR2	1.78e-03	12	111	2	GO:0098892
GeneOntologyCellularComponent	beta-catenin destruction complex	APC CTNNB1	2.10e-03	13	111	2	GO:0030877
GeneOntologyCellularComponent	neurotransmitter receptor complex	HTR3E HTR3C GRIN1	2.38e-03	50	111	3	GO:0098878
GeneOntologyCellularComponent	phospholipid-translocating ATPase complex	ATP10B ATP10D	2.44e-03	14	111	2	GO:1990531
GeneOntologyCellularComponent	nuclear membrane	NUP98 APC CEP128 DNAJC2 SYNE2 PLCB1 CTNNB1	2.62e-03	349	111	7	GO:0031965
GeneOntologyCellularComponent	nuclear envelope	NUP98 APC CEP128 DNAJC2 LMO7 SYNE2 PLCB1 OTULINL CTNNB1	3.00e-03	560	111	9	GO:0005635
GeneOntologyCellularComponent	Wnt signalosome	APC CTNNB1	3.19e-03	16	111	2	GO:1990909
HumanPheno	Infection-related seizure	CPA6 HCN1 CHD2 CNKSR2 GRIN1 WAC KCNA2	2.43e-05	145	32	7	HP:0032892
HumanPheno	Seizure precipitated by febrile infection	CPA6 HCN1 CHD2 CNKSR2 GRIN1 WAC KCNA2	2.43e-05	145	32	7	HP:0032894
HumanPheno	Febrile seizure (within the age range of 3 months to 6 years)	CPA6 HCN1 CHD2 CNKSR2 GRIN1 WAC KCNA2	2.43e-05	145	32	7	HP:0002373
HumanPheno	Borderline personality disorder	WAC RORA	3.82e-05	2	32	2	HP:0012076
HumanPheno	Brain neoplasm	FLI1 POLE APC	1.19e-04	16	32	3	HP:0030692
MousePheno	increased intestinal adenocarcinoma incidence	POLE APC RNF20 CTNNB1	9.84e-06	22	88	4	MP:0002957
MousePheno	increased large intestine adenocarcinoma incidence	POLE APC RNF20	1.32e-05	8	88	3	MP:0009310
Domain	DUF4414	HUWE1 REV1	3.44e-05	2	110	2	PF14377
Domain	DUF4414	HUWE1 REV1	3.44e-05	2	110	2	IPR025527
Domain	-	FLI1 ERG CNKSR2 SCML2 L3MBTL1	4.09e-04	106	110	5	1.10.150.50
Domain	SAM/pointed	FLI1 ERG CNKSR2 SCML2 L3MBTL1	6.42e-04	117	110	5	IPR013761
Domain	Arm	APC CTNNB1 CTNND2	7.92e-04	31	110	3	PF00514
Domain	ARM-like	APC FRYL HUWE1 RIC8B ULK4 CTNNB1 CTNND2	1.10e-03	270	110	7	IPR011989
Domain	MBT	SCML2 L3MBTL1	1.20e-03	9	110	2	SM00561
Domain	MBT	SCML2 L3MBTL1	1.20e-03	9	110	2	PS51079
Domain	Sulfotransfer_1	NDST1 CHST1 SULT2A1	1.23e-03	36	110	3	PF00685
Domain	Sulfotransferase_dom	NDST1 CHST1 SULT2A1	1.23e-03	36	110	3	IPR000863
Domain	MBT	SCML2 L3MBTL1	1.50e-03	10	110	2	PF02820
Domain	Mbt	SCML2 L3MBTL1	1.50e-03	10	110	2	IPR004092
Domain	Hydrolase_3	ATP10B ATP10D	1.50e-03	10	110	2	PF08282
Domain	ARM_REPEAT	APC CTNNB1 CTNND2	1.68e-03	40	110	3	PS50176
Domain	ARM	APC CTNNB1 CTNND2	1.68e-03	40	110	3	SM00185
Domain	PNT	FLI1 ERG	1.83e-03	11	110	2	PS51433
Domain	SAM_PNT	FLI1 ERG	1.83e-03	11	110	2	PF02198
Domain	XK-related	XKR6 XKR4	1.83e-03	11	110	2	PF09815
Domain	XK_rel	XKR6 XKR4	1.83e-03	11	110	2	IPR018629
Domain	Pointed_dom	FLI1 ERG	1.83e-03	11	110	2	IPR003118
Domain	SAM_PNT	FLI1 ERG	1.83e-03	11	110	2	SM00251
Domain	-	APC FRYL RIC8B ULK4 CTNNB1 CTNND2	2.02e-03	222	110	6	1.25.10.10
Domain	Armadillo	APC CTNNB1 CTNND2	2.67e-03	47	110	3	IPR000225
Domain	P_typ_ATPase_c	ATP10B ATP10D	2.99e-03	14	110	2	IPR032630
Domain	P-type_ATPase_N	ATP10B ATP10D	2.99e-03	14	110	2	IPR032631
Domain	P-type_ATPase_IV	ATP10B ATP10D	2.99e-03	14	110	2	IPR006539
Domain	PhoLip_ATPase_C	ATP10B ATP10D	2.99e-03	14	110	2	PF16212
Domain	PhoLip_ATPase_N	ATP10B ATP10D	2.99e-03	14	110	2	PF16209
Domain	-	ARID4B ARID5B	3.43e-03	15	110	2	1.10.150.60
Domain	BRIGHT	ARID4B ARID5B	3.43e-03	15	110	2	SM00501
Domain	EF-hand_like	PLCB1 PLCL1	3.43e-03	15	110	2	PF09279
Domain	ARID_dom	ARID4B ARID5B	3.43e-03	15	110	2	IPR001606
Domain	ARID	ARID4B ARID5B	3.43e-03	15	110	2	PS51011
Domain	PI-PLC-Y	PLCB1 PLCL1	3.43e-03	15	110	2	PF00387
Domain	PLCYc	PLCB1 PLCL1	3.43e-03	15	110	2	SM00149
Domain	PLipase_C_Pinositol-sp_Y	PLCB1 PLCL1	3.43e-03	15	110	2	IPR001711
Domain	-	CYTH2 CYTH1	3.43e-03	15	110	2	1.10.1000.11
Domain	PIPLC_Y_DOMAIN	PLCB1 PLCL1	3.43e-03	15	110	2	PS50008
Domain	ARID	ARID4B ARID5B	3.43e-03	15	110	2	PF01388
Domain	Sec7	CYTH2 CYTH1	3.43e-03	15	110	2	PF01369
Domain	PI-PLC_fam	PLCB1 PLCL1	3.43e-03	15	110	2	IPR001192
Domain	PLC_EF-hand-like	PLCB1 PLCL1	3.43e-03	15	110	2	IPR015359
Domain	Sec7_alpha_orthog	CYTH2 CYTH1	3.43e-03	15	110	2	IPR023394
Domain	SEC7	CYTH2 CYTH1	3.91e-03	16	110	2	PS50190
Domain	Sec7	CYTH2 CYTH1	3.91e-03	16	110	2	SM00222
Domain	Sec7_dom	CYTH2 CYTH1	3.91e-03	16	110	2	IPR000904
Domain	ARM-type_fold	APC FRYL HUWE1 RIC8B ULK4 CTNNB1 CTNND2	3.94e-03	339	110	7	IPR016024
Domain	PI-PLC-X	PLCB1 PLCL1	4.95e-03	18	110	2	PF00388
Domain	PLCXc	PLCB1 PLCL1	4.95e-03	18	110	2	SM00148
Domain	PIPLC_X_DOMAIN	PLCB1 PLCL1	5.51e-03	19	110	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCB1 PLCL1	5.51e-03	19	110	2	IPR000909
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RABEP2 HCN1 CYTH2 CYTH1 ADGRB2 APC CNKSR2 ZNF318 GRIN1 HUWE1 MYEF2 FAM171A1 CYFIP1 KCNA2 PTPRD SYNE2 PLCB1 PLCL1 CTNNB1 CTNND2	4.04e-11	963	113	20	28671696
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	HCN1 ADGRB2 CNKSR2 GRIN1 CYFIP1 KCNA2 PLCB1 PLCL1 CTNNB1 CTNND2	1.04e-08	251	113	10	27507650
Pubmed	E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.	APC HUWE1 CTNNB1	3.34e-08	3	113	3	28137882
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	HCN1 APC CNKSR2 GRIN1 XKR4 KCNA2 DYRK1B PLCB1 CTNNB1 CTNND2	2.15e-07	347	113	10	17114649
Pubmed	Huntingtin interacting proteins are genetic modifiers of neurodegeneration.	SRP9 WAC SLC25A3 BCAP31 PIK3R1 RNF20 CTNNB1	3.91e-06	197	113	7	17500595
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	NDST1 CENPB APC PSMC6 CNKSR2 CEP192 SEC22A CNNM3 TENM3 PTPRM GALNT5 MLPH	4.10e-06	719	113	12	35337019
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	GJC1 SLC25A3 CNNM3 CYFIP1 PTPRM SLC20A1 PLCB1 CTNNB1 SNTB1	4.16e-06	377	113	9	38117590
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	LMCD1 HCN1 ADGRB2 XKR4 CNNM3 KCNA2 SLC20A1 PLCB1 CTNND2	7.40e-06	405	113	9	38187761
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ARID4B MYO1D POLE CHD2 DNAH7 MYEF2 CYFIP1 SYNE2 ARID5B PLCB1 CTNND2	7.79e-06	638	113	11	31182584
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RABEP2 RPL36 MYO1D NUP98 PSMC6 CEP192 HUWE1 FAM171A1 CNNM3 PTPRD PTPRM PIK3R1 SYNE2 SNTB1	8.11e-06	1049	113	14	27880917
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	FAM171A1 CNNM3 CYFIP1 TENM3 PTPRM PIK3R1 PLCB1 CTNNB1 SNTB1	1.01e-05	421	113	9	36976175
Pubmed	Tumor Suppressor Adenomatous Polyposis Coli Sustains Dendritic Cell Tolerance through IL-10 in a β-Catenin-Dependent Manner.	APC CTNNB1	1.05e-05	2	113	2	37000474
Pubmed	APC/CTNNB1 (beta-catenin) pathway alterations in human prostate cancers.	APC CTNNB1	1.05e-05	2	113	2	11921277
Pubmed	5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option.	HTR3E HTR3C	1.05e-05	2	113	2	23928294
Pubmed	ERG and FLI1 protein expression in epithelioid sarcoma.	FLI1 ERG	1.05e-05	2	113	2	24072183
Pubmed	Testing models of the APC tumor suppressor/β-catenin interaction reshapes our view of the destruction complex in Wnt signaling.	APC CTNNB1	1.05e-05	2	113	2	24931405
Pubmed	Loss of Apc Cooperates with Activated Oncogenes to Induce Liver Tumor Formation in Mice.	APC CTNNB1	1.05e-05	2	113	2	33545120
Pubmed	In utero and neonatal sensitivity of ApcMin/+ mice to radiation-induced intestinal neoplasia.	APC CTNNB1	1.05e-05	2	113	2	16638711
Pubmed	Recurrent Mutations in APC and CTNNB1 and Activated Wnt/β-catenin Signaling in Intraductal Papillary Neoplasms of the Bile Duct: A Whole Exome Sequencing Study.	APC CTNNB1	1.05e-05	2	113	2	30212390
Pubmed	Synergistic Role of Endothelial ERG and FLI1 in Mediating Pulmonary Vascular Homeostasis.	FLI1 ERG	1.05e-05	2	113	2	28248553
Pubmed	Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein.	APC CTNNB1	1.05e-05	2	113	2	12628243
Pubmed	H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes.	PIK3R1 CTNNB1	1.05e-05	2	113	2	10477752
Pubmed	APC/β-catenin-rich complexes at membrane protrusions regulate mammary tumor cell migration and mesenchymal morphology.	APC CTNNB1	1.05e-05	2	113	2	23302090
Pubmed	The APC/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: a mutational analysis.	APC CTNNB1	1.05e-05	2	113	2	11920497
Pubmed	Regulation of the phosphorylation and nuclear import and export of β-catenin by APC and its cancer-related truncated form.	APC CTNNB1	1.05e-05	2	113	2	24496450
Pubmed	The p85 subunit of phosphoinositide 3-kinase is associated with beta-catenin in the cadherin-based adhesion complex.	PIK3R1 CTNNB1	1.05e-05	2	113	2	11716761
Pubmed	CTNNB1 and APC Mutations in Sinonasal Myxoma : Expanding the Spectrum of Tumors Driven By WNT/β-catenin Pathway.	APC CTNNB1	1.05e-05	2	113	2	37589277
Pubmed	A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation.	APC CTNNB1	1.05e-05	2	113	2	22509309
Pubmed	The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells.	APC CTNNB1	1.05e-05	2	113	2	8670282
Pubmed	CARD9 Promotes Sex-Biased Colon Tumors in the APCmin Mouse Model.	APC CARD9	1.05e-05	2	113	2	25941350
Pubmed	No difference in the occurrence of mismatch repair defects and APC and CTNNB1 genes mutation in a multi-racial colorectal carcinoma patient cohort.	APC CTNNB1	1.05e-05	2	113	2	17454753
Pubmed	Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC.	APC CTNNB1	1.05e-05	2	113	2	16382042
Pubmed	[Abnormalities of chromosome 8, APC and beta-catenin genes in aggressive fibromatosis].	APC CTNNB1	1.05e-05	2	113	2	18646694
Pubmed	Hypermethylation of APC promoter 1A is associated with moderate activation of Wnt signalling pathway in a subset of colorectal serrated adenomas.	APC CTNNB1	1.05e-05	2	113	2	19912361
Pubmed	The Ets family member Erg gene is expressed in mesodermal tissues and neural crests at fundamental steps during mouse embryogenesis.	FLI1 ERG	1.05e-05	2	113	2	10704859
Pubmed	Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.	FLI1 ERG	1.05e-05	2	113	2	30500808
Pubmed	Transdifferentiation of erythroblasts to megakaryocytes using FLI1 and ERG transcription factors.	FLI1 ERG	1.05e-05	2	113	2	26063314
Pubmed	β-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53.	APC CTNNB1	1.05e-05	2	113	2	38324534
Pubmed	Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling.	APC CTNNB1	1.05e-05	2	113	2	12426568
Pubmed	Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling.	APC CTNNB1	1.05e-05	2	113	2	21949247
Pubmed	Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription.	APC CTNNB1	1.05e-05	2	113	2	12606575
Pubmed	APC mutations in sporadic medulloblastomas.	APC CTNNB1	1.05e-05	2	113	2	10666372
Pubmed	Fibro-osseous lesions of the craniofacial bones: β-catenin immunohistochemical analysis and CTNNB1 and APC mutation analysis.	APC CTNNB1	1.05e-05	2	113	2	24664543
Pubmed	Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.	FLI1 ERG	1.05e-05	2	113	2	33275876
Pubmed	Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas.	APC CTNNB1	1.05e-05	2	113	2	15563600
Pubmed	ERG and FLI1 are useful immunohistochemical markers in phosphaturic mesenchymal tumors.	FLI1 ERG	1.05e-05	2	113	2	26122367
Pubmed	Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level.	APC CTNNB1	1.05e-05	2	113	2	10545404
Pubmed	Nesprins are mechanotransducers that discriminate epithelial-mesenchymal transition programs.	SYNE2 CTNNB1	1.05e-05	2	113	2	32790861
Pubmed	Association analysis of Wnt pathway genes on prostate-specific antigen recurrence after radical prostatectomy.	APC CTNNB1	1.05e-05	2	113	2	19777185
Pubmed	The APC network regulates the removal of mutated cells from colonic crypts.	APC CTNNB1	1.05e-05	2	113	2	24685131
Pubmed	Further upregulation of beta-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice.	APC CTNNB1	1.05e-05	2	113	2	18204079
Pubmed	MSK1-Mediated β-Catenin Phosphorylation Confers Resistance to PI3K/mTOR Inhibitors in Glioblastoma.	RPS6KA5 CTNNB1	1.05e-05	2	113	2	27196759
Pubmed	Inhibition of WNT signaling in the bone marrow niche prevents the development of MDS in the Apcdel/+ MDS mouse model.	APC CTNNB1	1.05e-05	2	113	2	28348148
Pubmed	The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.	APC CTNNB1	1.05e-05	2	113	2	12045208
Pubmed	Low frequency of beta-catenin gene mutations in pilomatricoma.	APC CTNNB1	1.05e-05	2	113	2	12575848
Pubmed	The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma.	APC CTNNB1	1.05e-05	2	113	2	34986841
Pubmed	Activation of beta-catenin is a late event in the pathogenesis of nephroblastomas and rarely correlated with genetic changes of the APC gene.	APC CTNNB1	1.05e-05	2	113	2	22081130
Pubmed	Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability.	APC CTNNB1	1.05e-05	2	113	2	20544848
Pubmed	Apc tumor suppressor gene is the "zonation-keeper" of mouse liver.	APC CTNNB1	1.05e-05	2	113	2	16740478
Pubmed	A genetic study of the role of the Wnt/beta-catenin signalling in Paneth cell differentiation.	APC CTNNB1	1.05e-05	2	113	2	18948094
Pubmed	β-Catenin signaling dosage dictates tissue-specific tumor predisposition in Apc-driven cancer.	APC CTNNB1	1.05e-05	2	113	2	23045279
Pubmed	Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation.	APC CTNNB1	1.05e-05	2	113	2	33060621
Pubmed	N-terminal nesprin-2 variants regulate β-catenin signalling.	SYNE2 CTNNB1	1.05e-05	2	113	2	27321956
Pubmed	Loss of adenomatous polyposis coli gene function disrupts thymic development.	APC CTNNB1	1.05e-05	2	113	2	16025118
Pubmed	Determination of Rate-Limiting Factor for Formation of Beta-Catenin Destruction Complexes Using Absolute Protein Quantification.	APC CTNNB1	1.05e-05	2	113	2	28810742
Pubmed	RPTP delta and the novel protein tyrosine phosphatase RPTP psi are expressed in restricted regions of the developing central nervous system.	PTPRD PTPRM	1.05e-05	2	113	2	8989520
Pubmed	Common genetic variants in Wnt signaling pathway genes as potential prognostic biomarkers for colorectal cancer.	APC CTNNB1	1.05e-05	2	113	2	23405266
Pubmed	Adenomatous polyposis coli regulates endothelial cell migration independent of roles in beta-catenin signaling and cell-cell adhesion.	APC CTNNB1	1.05e-05	2	113	2	20519433
Pubmed	CTNNB1 genotyping and APC screening in pediatric desmoid tumors: a proposed algorithm.	APC CTNNB1	1.05e-05	2	113	2	22372443
Pubmed	Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex.	PLCB1 CTNNB1	1.05e-05	2	113	2	16339037
Pubmed	The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells.	APC CTNNB1	1.05e-05	2	113	2	28010732
Pubmed	Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.	FLI1 ERG	1.05e-05	2	113	2	19666492
Pubmed	Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor.	CYTH2 CYTH1	1.05e-05	2	113	2	9050849
Pubmed	Analysis of APC/beta-catenin genes mutations and Wnt signalling pathway in desmoid-type fibromatosis.	APC CTNNB1	1.05e-05	2	113	2	17558858
Pubmed	Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells.	APC CTNNB1	1.05e-05	2	113	2	11157977
Pubmed	Direct metabolic regulation of beta-catenin activity by the p85alpha regulatory subunit of phosphoinositide 3-OH kinase.	PIK3R1 CTNNB1	1.05e-05	2	113	2	15817165
Pubmed	Exploration of the APC/beta-catenin (WNT) pathway and a histologic classification system for pulmonary artery intimal sarcoma. A study of 18 cases.	APC CTNNB1	1.05e-05	2	113	2	18807072
Pubmed	The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance.	HTR3E HTR3C	1.05e-05	2	113	2	15157181
Pubmed	APC germline pathogenic variants and epithelial ovarian cancer: causal or coincidental findings?	APC CTNNB1	1.05e-05	2	113	2	36270768
Pubmed	APC and CTNNB1 mutations are rare in sporadic ependymomas.	APC CTNNB1	1.05e-05	2	113	2	16843107
Pubmed	Desmoid tumor: a disease opportune for molecular insights.	APC CTNNB1	1.05e-05	2	113	2	17952864
Pubmed	Apc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms.	APC CTNNB1	1.05e-05	2	113	2	23547052
Pubmed	Aberrant beta-catenin expression and adenomatous polyposis coli gene mutation in ameloblastoma and odontogenic carcinoma.	APC CTNNB1	1.05e-05	2	113	2	18486530
Pubmed	Lower Rate of CTNNB1 Mutations and Higher Rate of APC Mutations in Desmoid Fibromatosis of the Breast: A Series of 134 Tumors.	APC CTNNB1	1.05e-05	2	113	2	32590455
Pubmed	Hepatocellular Carcinomas With Mutational Activation of Beta-Catenin Require Choline and Can Be Detected by Positron Emission Tomography.	APC CTNNB1	1.05e-05	2	113	2	31194980
Pubmed	β-Catenin Is a Candidate Therapeutic Target for Myeloid Neoplasms with del(5q).	APC CTNNB1	1.05e-05	2	113	2	28611040
Pubmed	Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients.	APC CTNNB1	1.05e-05	2	113	2	19966865
Pubmed	Regulated Wnt/beta-catenin signaling sustains adult spermatogenesis in mice.	APC CTNNB1	1.05e-05	2	113	2	24258210
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SCRN3 APC CHD2 FRYL ZNF318 CEP192 HUWE1 SPPL2B SCML2 SLC20A1 PIK3R1 NKAPD1 ARID5B OTULINL	1.17e-05	1084	113	14	11544199
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ILDR2 RPL36 MYO1D CYTH2 APC CNKSR2 GRIN1 MYEF2 SLC25A3 CYFIP1 CLCN6 LMO7 TLN1 PLCL1 CTNNB1 CTNND2	1.60e-05	1431	113	16	37142655
Pubmed	Mapping of unconventional myosins in mouse and human.	HTR1B MYO1D APC RORA	1.84e-05	48	113	4	8884266
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	MYO1D APC ZNF318 CEP192 HUWE1 ALKBH5 CYFIP1 LMO7 ARID5B CTNNB1	2.31e-05	588	113	10	38580884
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	RABEP2 ERG NUP98 APC EVPL LMO7 TLN1 RNF20	2.43e-05	360	113	8	33111431
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	HIPK4 APC FRYL CEP192 DYRK4 DNAH7 FAM171A1 LMO7 SYNE2 DYRK1B R3HDM1 KIF1C	2.46e-05	861	113	12	36931259
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	RPL36 ARID4B RPS6KA5 APC PSMC6 MYEF2 DNAJC2 PLCB1 IGSF9B	2.61e-05	475	113	9	31040226
Pubmed	CRL7SMU1 E3 ligase complex-driven H2B ubiquitylation functions in sister chromatid cohesion by regulating SMC1 expression.	APC HUWE1 RNF20	2.63e-05	18	113	3	29507117
Pubmed	Proteomic analysis of in vivo phosphorylated synaptic proteins.	SLC20A1 DYRK1B PLCB1 CTNND2	2.74e-05	53	113	4	15572359
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RPL36 MYO1D NUP98 ZNF318 HUWE1 MYEF2 SLC25A3 CNNM3 LMO7 SLC20A1 TLN1 SYNE2 CTNNB1	2.94e-05	1024	113	13	24711643
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	PSMC6 HUWE1 MYEF2 CYFIP1 TLN1 CTNNB1	3.00e-05	182	113	6	31067453
Pubmed	A human MAP kinase interactome.	ARID4B RPS6KA5 CYTH2 NUP98 APC EVPL PIK3R1 DYRK1B PLCB1	3.12e-05	486	113	9	20936779
Interaction	DLGAP1 interactions	ADGRB2 APC CNKSR2 GRIN1 HUWE1 CYFIP1 KCNA2 CTNNB1 CTNND2	6.84e-07	180	111	9	int:DLGAP1
Interaction	PRKCG interactions	CYTH2 CNKSR2 GRIN1 HUWE1 SLC25A3 CYFIP1 CTNNB1	4.79e-06	121	111	7	int:PRKCG
Interaction	TNIK interactions	HCN1 APC CNKSR2 GRIN1 HUWE1 DNAJC2 CYFIP1 PTPRD SYNE2 CTNNB1 CTNND2	8.34e-06	381	111	11	int:TNIK
Interaction	HDAC4 interactions	RPL36 ARID4B RPS6KA5 APC PSMC6 HUWE1 MYEF2 DNAJC2 SLC25A3 BCAP31 LMO7 PLCB1 IGSF9B CTNNB1 KIF1C	1.41e-05	744	111	15	int:HDAC4
Interaction	ETV1 interactions	ERG RPS6KA5 KCNA2 ETAA1	1.86e-05	29	111	4	int:ETV1
Interaction	TAX1BP3 interactions	CYTH2 CYTH1 APC ETAA1 CTNNB1	3.17e-05	66	111	5	int:TAX1BP3
Interaction	SYNE3 interactions	UBE2J1 NUP98 APC ZNF318 CEP192 CEP128 BCAP31 LMO7 SYNE2 ETAA1 OTULINL	3.43e-05	444	111	11	int:SYNE3
Interaction	NYAP1 interactions	CYFIP1 PIK3R1 TLN1	4.47e-05	13	111	3	int:NYAP1
Interaction	SYNGAP1 interactions	CYTH2 ADGRB2 CNKSR2 GRIN1 HUWE1 CYFIP1 SYNE2 PLCL1 CTNNB1	5.10e-05	307	111	9	int:SYNGAP1
Interaction	RAB35 interactions	UBE2J1 MYO1D APC MYEF2 FAM171A1 CNNM3 BCAP31 CYFIP1 PIK3R1 SYNE2 PLCB1 CTNNB1	7.59e-05	573	111	12	int:RAB35
Interaction	NR3C1 interactions	RABEP2 ARID4B MYO1D CENPB RPS6KA5 POLE NUP98 CHD2 DNAH7 MYEF2 CYFIP1 SYNE2 ARID5B PLCB1 CTNNB1 CTNND2	8.53e-05	974	111	16	int:NR3C1
Interaction	GJA1 interactions	ILDR2 UBE2J1 MYO1D GJC1 APC HTR3C FAM171A1 CNNM3 BCAP31 PIK3R1 SYNE2 CTNNB1	8.94e-05	583	111	12	int:GJA1
Cytoband	Xp22.12	CNKSR2 BCLAF3	1.67e-04	8	113	2	Xp22.12
Cytoband	1p35	MAN1C1 ADGRB2	4.60e-04	13	113	2	1p35
GeneFamily	5-hydroxytryptamine receptors, ionotropic	HTR3E HTR3C	1.92e-04	5	80	2	172
GeneFamily	Sterile alpha motif domain containing\|MBT domain containing	SCML2 L3MBTL1	6.82e-04	9	80	2	1263
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	APC CTNNB1 CTNND2	9.06e-04	43	80	3	409
GeneFamily	Blood group antigens\|XK related family	XKR6 XKR4	1.04e-03	11	80	2	955
GeneFamily	AT-rich interaction domain containing	ARID4B ARID5B	1.96e-03	15	80	2	418
GeneFamily	ATPase phospholipid transporting	ATP10B ATP10D	1.96e-03	15	80	2	1210
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCB1 PLCL1	3.15e-03	19	80	2	832
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRD PTPRM	3.84e-03	21	80	2	813
GeneFamily	DNA polymerases	POLE REV1	4.61e-03	23	80	2	535
GeneFamily	Fibronectin type III domain containing	MYOM3 PTPRD PTPRM IGSF9B	5.55e-03	160	80	4	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MYOM3 PTPRD PTPRM IGSF9B	5.67e-03	161	80	4	593
GeneFamily	ETS transcription factor family	FLI1 ERG	6.78e-03	28	80	2	534
GeneFamily	Sterile alpha motif domain containing	CNKSR2 SCML2 L3MBTL1	6.99e-03	88	80	3	760
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	MYO1D APC CEP192 PLCL1	8.51e-03	181	80	4	694
Coexpression	GSE19825_NAIVE_VS_IL2RAHIGH_DAY3_EFF_CD8_TCELL_UP	CASQ1 CHST1 SCML2 CYFIP1 KCNA2 PTPRM IGSF9B PLCL1	2.58e-06	200	113	8	M4299
Coexpression	GAO_LARGE_INTESTINE_24W_C5_LGR5POS_STEM_CELL	CPA6 SLC38A4 MYOM3 EVPL ATP10B	6.16e-06	60	113	5	M39155
Coexpression	LAKE_ADULT_KIDNEY_C26_MESANGIAL_CELLS	MYO1D PTPRD PTPRM LMO7 ARID5B RORA PLCL1	1.20e-05	177	113	7	M39245
CoexpressionAtlas	kidney_adult_RenCorpuscGlomer_k-means-cluster#4_top-relative-expression-ranked_1000	MYO1D LMCD1 LMO7 PIK3R1 ARID5B PLCL1 SNTB1	1.36e-05	148	112	7	gudmap_kidney_adult_RenCorpuscGlomer_k4_1000
CoexpressionAtlas	kidney_adult_RenCorpuscGlomer_top-relative-expression-ranked_1000	ILDR2 FLI1 ERG MYO1D LMCD1 FRYL CHST1 PTPRM LMO7 PIK3R1 ARID5B PLCB1 RORA PLCL1 SNTB1 KIF1C	1.47e-05	878	112	16	gudmap_kidney_adult_RenCorpuscGlomer_1000
CoexpressionAtlas	kidney_adult_Mesangium_Meis_top-relative-expression-ranked_500	ACP6 FLI1 MYO1D LMCD1 ATP10D LMO7 PIK3R1 ARID5B PLCL1 SNTB1	9.22e-05	429	112	10	gudmap_kidney_adult_Mesangium_Meis_500
CoexpressionAtlas	facebase_RNAseq_e10.5_MaxArch_2500_K3	FLI1 UBE2J1 ERG ARID4B POLE APC CNKSR2 CEP192 CEP128 DNAJC2 WAC BCLAF3 SLC20A1 NKAPD1 SYNE2 ETAA1 R3HDM1 ZNF654	9.45e-05	1252	112	18	facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlas	kidney_adult_Mesangium_Meis_k-means-cluster#2_top-relative-expression-ranked_1000	ACP6 LMCD1 ADGRG6 BCLAF3 LMO7 PIK3R1 ARID5B PLCL1 SNTB1	9.61e-05	348	112	9	gudmap_kidney_adult_Mesangium_Meis_k2_1000
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ARID4B CHD2 HUWE1 SLC20A1 SYNE2 PLCB1 RORA CTNNB1	2.82e-08	188	113	8	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CNKSR2 XKR4 CEP128 RGS16 KCNA2 CLCN6 TENM3	4.25e-07	182	113	7	a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ILDR2 ADGRB2 XKR4 ADGRG6 RIC8B TENM3 IGSF9B	5.29e-07	188	113	7	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ILDR2 ADGRB2 XKR4 ADGRG6 RIC8B TENM3 IGSF9B	5.29e-07	188	113	7	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FLI1 ERG LMCD1 ADGRG6 FAM171A1 PTPRM PLCB1	6.31e-07	193	113	7	9ba688b35a9ead5d04691b3f3f15484f02dbbd0d
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLI1 ERG MYO1D FAM171A1 PTPRD PTPRM CTNND2	6.31e-07	193	113	7	e1d546165dcc2392f540162206852c4717d7306f
ToppCell	mild-Treg\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LMCD1 CEP128 PIK3R1 SYNE2 ARID5B RORA PLCL1	7.24e-07	197	113	7	39800e6e83f2d333b753d121c7aeb2912b91faa2
ToppCell	severe-Treg\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LMCD1 CEP128 PIK3R1 SYNE2 ARID5B RORA PLCL1	7.49e-07	198	113	7	4935b40fc848037a06055f30d90bde940b9d5321
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Vein\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FLI1 ERG LMCD1 ADGRG6 FAM171A1 SYNE2 PLCB1	8.01e-07	200	113	7	7eb366b2c5394af7c77650bde6261e7dac67154e
ToppCell	TCGA-Mesothelium-Primary_Tumor-Mesothelioma-Biphasic-6\|TCGA-Mesothelium / Sample_Type by Project: Shred V9	FLI1 NDST1 HTR1B GJC1 CHST1 PTPRM	3.28e-06	159	113	6	85501c636cd04f15ba1be24df1ba7ac909633ce8
ToppCell	normal-na-Lymphocytic_T-T4_reg-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CPA6 ARID4B PIK3R1 SYNE2 ARID5B RORA	3.78e-06	163	113	6	43887e7687fc6367efac0c1f56a9534b06f47b7f
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LMCD1 CEP128 SYNE2 ARID5B RORA PLCL1	4.06e-06	165	113	6	dbe231d00843cae917efd1abea6079ace3b45cdf
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LMCD1 CEP128 SYNE2 ARID5B RORA PLCL1	4.06e-06	165	113	6	9ccce713d4122054bf4bef4a7126d90cf9141b84
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ILDR2 XKR4 DNAH7 ADGRG6 TENM3 SYNE2	4.50e-06	168	113	6	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	COVID-19_Severe-Treg\|COVID-19_Severe / disease group, cell group and cell class	RPS6KA5 PIK3R1 SYNE2 ARID5B RORA PLCL1	4.82e-06	170	113	6	d61269a51283125835884c4aa50623756c4fdda2
ToppCell	Healthy_donor-Treg\|World / disease group, cell group and cell class (v2)	LMCD1 KCNA2 SYNE2 ARID5B RORA PLCL1	5.51e-06	174	113	6	dc3b06420b0ad9c7060571e7bf5714e028d598bf
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERG LMCD1 EVPL ADGRG6 LMO7 MLPH	6.48e-06	179	113	6	a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCell	COVID-19-Heart-EC_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FLI1 ERG FRYL PTPRM SYNE2 PLCB1	6.48e-06	179	113	6	2a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ERG CEP128 SEC22A ADGRG6 PTPRM MLPH	6.68e-06	180	113	6	baa5825e6ce23a98d9c21d024a4b0ab8ba353d0c
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ERG CEP128 SEC22A ADGRG6 PTPRM MLPH	6.68e-06	180	113	6	2d608b9394d28d19cfc85c6ac94003d5177c8a92
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ERG CEP128 SEC22A ADGRG6 PTPRM MLPH	6.68e-06	180	113	6	0f9b27054358c4737eed06c8ea01987cccc3cb55
ToppCell	(2)_NK/T-(230)_CD4+/CD25+_Reg_T_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	RPL36 LMCD1 CNKSR2 CEP128 KCNA2 ARID5B	6.90e-06	181	113	6	ad14c7111d4fb924afd233cb114447f195373a7c
ToppCell	facs-Lung-Endomucin-24m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LMCD1 GJC1 AGBL3 ADGRG6 CARD9 MLPH	7.12e-06	182	113	6	be9c312a44868d4ee266a64d066feb8c5bce5687
ToppCell	facs-Lung-Endomucin-24m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LMCD1 GJC1 AGBL3 ADGRG6 CARD9 MLPH	7.12e-06	182	113	6	74dbb706bcaa0f8c922bf3b0424bce5bb27167fa
ToppCell	Control-Endothelial_cells-Pulmonary_venous_endothelial_cells\|Control / group, cell type (main and fine annotations)	FLI1 ERG LMCD1 ADGRG6 FAM171A1 PLCB1	7.35e-06	183	113	6	46be9f96755c7b65aeac061d95d15abeb6466034
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	TENM3 PTPRM PLCB1 RORA CTNND2 SNTB1	7.82e-06	185	113	6	1d874608aa2062024323512f68889219471b2f00
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO1D CNKSR2 PTPRD LMO7 PIK3R1 R3HDM1	8.06e-06	186	113	6	84ba666237c18189d7e7556bd92dd953af733c00
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	FLI1 ERG FRYL PTPRM SYNE2 PLCB1	8.31e-06	187	113	6	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	droplet-Tongue-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPL36 ARID4B CHD2 WAC SYNE2 ARID5B	8.57e-06	188	113	6	d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCell	COVID-19-Heart-EC_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FLI1 ERG PTPRM SYNE2 PLCB1 OPN5	8.83e-06	189	113	6	fe49852ba15f948b384d6b4c258927c70b741357
ToppCell	Control-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLI1 ERG FAM171A1 PTPRD CTNND2 SNTB1	8.83e-06	189	113	6	5d7ae1ead7f4fbaeec26f651833c9c2106e1e4d1
ToppCell	COVID-19-lung-Artery_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ERG FRYL ADGRG6 FAM171A1 PTPRM PLCB1	9.10e-06	190	113	6	07b675befcd1d0a9c90cb17b5d22323468325d51
ToppCell	COVID-19-Heart-EC_3\|Heart / Disease (COVID-19 only), tissue and cell type	FLI1 ERG ADGRG6 PTPRM PLCB1 MLPH	9.10e-06	190	113	6	78e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCell	RA-09._Endothelium_I\|World / Chamber and Cluster_Paper	FLI1 ERG ADGRG6 PTPRM SYNE2 PLCB1	9.38e-06	191	113	6	c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYOM3 PIK3R1 NKAPD1 RORA PLCL1 OTULINL	9.66e-06	192	113	6	1c0ce299cee9ab5cdea256f3e8c1e5598577a8b6
ToppCell	COVID-19_Moderate-CD4+_Tcm\|World / disease group, cell group and cell class	RPL36 RGS16 PIK3R1 SYNE2 ARID5B RORA	9.66e-06	192	113	6	5f94310f1470487816fce697ffcdc2627fc66878
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	ARID4B CHD2 SLC20A1 SYNE2 RORA PLCL1	9.66e-06	192	113	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	COVID-19_Severe-CD4+_Tcm\|World / disease group, cell group and cell class	RGS16 PIK3R1 SYNE2 ARID5B RORA PLCL1	9.66e-06	192	113	6	3352f13a6e706991dcf3ec173587bb6aba36a385
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADGRB2 CNKSR2 PTPRD LMO7 PIK3R1 R3HDM1	9.66e-06	192	113	6	5c7e8b80b44d9ce55c797cdf8267ac5382e26cac
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLI1 ERG FAM171A1 PTPRM PLCB1 CTNND2	9.95e-06	193	113	6	e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLI1 ERG FAM171A1 PTPRM PLCB1 CTNND2	9.95e-06	193	113	6	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLI1 ERG FAM171A1 PTPRM PLCB1 CTNND2	9.95e-06	193	113	6	af5108260783e69a7d67896c5bf64f862525926d
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-Tregs\|blood / Manually curated celltypes from each tissue	LMCD1 CEP128 SYNE2 ARID5B RORA PLCL1	9.95e-06	193	113	6	2ffe44edf2b02d11a7c10513692eb697a10f911e
ToppCell	RV-09._Endothelium_I\|World / Chamber and Cluster_Paper	FLI1 ERG FRYL PTPRM SYNE2 PLCB1	9.95e-06	193	113	6	e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCell	RV-09._Endothelium_I\|RV / Chamber and Cluster_Paper	FLI1 ERG FRYL PTPRM SYNE2 PLCB1	1.02e-05	194	113	6	7b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1D XKR4 DNAH7 LMO7 SYNE2 PLCB1	1.02e-05	194	113	6	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLI1 ERG FAM171A1 PTPRM PLCB1 CTNND2	1.02e-05	194	113	6	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	Endothelial-endothelial_cell_of_vein\|World / Lineage, Cell type, age group and donor	FLI1 ERG LMCD1 ADGRG6 FAM171A1 PLCB1	1.02e-05	194	113	6	3cbd9622a68e89add90e589867d88c83c5a33476
ToppCell	LV-09._Endothelium_I\|World / Chamber and Cluster_Paper	FLI1 ERG FRYL PTPRM SYNE2 PLCB1	1.06e-05	195	113	6	19e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCell	COVID-19-Heart-EC_1\|Heart / Disease (COVID-19 only), tissue and cell type	FLI1 ERG FRYL PTPRM SYNE2 PLCB1	1.06e-05	195	113	6	50a193475db1bb1e05b8590225a553688c372c14
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNKSR2 KCNA2 PTPRD PLCB1 RORA R3HDM1	1.06e-05	195	113	6	787e95fb59c40bba784544b662fac37606ae1427
ToppCell	MatrixFB-Fibroblast-B_(Myofibroblast)\|MatrixFB / shred on cell class and cell subclass (v4)	LMCD1 RGS16 ADGRG6 ARID5B RORA OTULINL	1.09e-05	196	113	6	38ea0eaf42f95c321ca23570d0d7752980cf00f8
ToppCell	LV-09._Endothelium_I\|LV / Chamber and Cluster_Paper	FLI1 ERG FRYL PTPRM SYNE2 PLCB1	1.12e-05	197	113	6	f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCell	MS-IIF-Lymphocyte-T/NK-Treg\|IIF / Disease, condition lineage and cell class	RPL36 CNKSR2 PIK3R1 SYNE2 ARID5B PLCL1	1.15e-05	198	113	6	7bbf8403ecf9f8e403b04f18d265ece977cc49e7
ToppCell	severe-Treg\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LMCD1 CEP128 SYNE2 ARID5B RORA PLCL1	1.15e-05	198	113	6	377980b9f7d02818e1d145e6884604f8bfacc4f2
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HCN1 CNKSR2 XKR6 XKR4 PLCB1 R3HDM1	1.15e-05	198	113	6	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	FLI1 ERG LMCD1 GJC1 PTPRM PLCB1	1.15e-05	198	113	6	8689090bce9ab6e8f122426a404037e572c6713b
ToppCell	lymphoid-NK_cell-NK_cell\|NK_cell / Lineage, cell class and subclass	ARID4B WAC PIK3R1 SYNE2 RORA OTULINL	1.18e-05	199	113	6	945fbf5845403a8b22d04963f50ad69c414b6153
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Vein\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FLI1 ERG LMCD1 ADGRG6 FAM171A1 PLCB1	1.18e-05	199	113	6	cfb624c7728046fc7f3ef071f57e4d7b013f3fef
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ARID4B CYTH1 CHD2 FRYL PIK3R1 SYNE2	1.22e-05	200	113	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LMCD1 SYNE2 ARID5B RORA PLCL1	2.04e-05	130	113	5	d47d4ff1263815896470d854d25306eb36919e70
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_B\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	RABEP2 LMCD1 GRIN1 ADGRG6 RORA	2.72e-05	138	113	5	8d70e64843f7c3be8ee4203cc126fdf1001f0df5
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr\|Thalamus / BrainAtlas - Mouse McCarroll V32	CYTH2 MYOM3 ATP10B CCDC183	3.59e-05	73	113	4	f2361804ed2e052efc1236d8abfa39ab7cb68dd8
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr-Polydendrocyte.Tnr.Ctps_(Ctps)\|Thalamus / BrainAtlas - Mouse McCarroll V32	CYTH2 MYOM3 ATP10B CCDC183	3.59e-05	73	113	4	0ea6106a85b31d037c9aa16e1ad6a9bcb5b2eda9
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EVPL KCNA2 SYNE2 RORA CCDC183	3.68e-05	147	113	5	5e6dd2ddc67b3722f6528e7277cbc7f296098687
ToppCell	E18.5-samps-Mesenchymal-Pericyte-pericyte_B\|E18.5-samps / Age Group, Lineage, Cell class and subclass	LMCD1 RGS16 CARD9 SLC20A1 GALNT5	4.18e-05	151	113	5	8ba15ab24fe2e71df0a2a7511ca451ad2376bd91
ToppCell	severe_COVID-19-Treg\|severe_COVID-19 / disease group, cell group and cell class (v2)	LMCD1 GJC1 SYNE2 ARID5B RORA	4.18e-05	151	113	5	bef8f31d5c4345a346fcf15db0fa36265ac304e7
ToppCell	Bac-SEP-Lymphocyte-T_NK-CD4_TEM\|Bac-SEP / Disease, Lineage and Cell Type	HCN1 PTPRM PIK3R1 SYNE2 RORA	4.88e-05	156	113	5	ef6bad99bcb30956863cd490c613e251f3b27ba0
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-CD4_TEM\|ICU-NoSEP / Disease, Lineage and Cell Type	RPL36 KCNA2 SULT2A1 SYNE2 RORA	5.18e-05	158	113	5	8616b308d5c1a1042b23a9aaca971029ba732eb8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CPA6 MYO1D CASQ1 RGS16 PLCL1	5.34e-05	159	113	5	5ca96db4281abb5f646150ccf36adc66ab201c78
ToppCell	COVID-19_Moderate-MAIT\|World / disease group, cell group and cell class	EVPL SYNE2 PLCB1 RORA IGSF9B	5.50e-05	160	113	5	bf73c5fe87c1f243edec17d7a2c30fae5e2cfd6b
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-gdT\|ICU-NoSEP / Disease, Lineage and Cell Type	FAM171A1 PTPRM SYNE2 ARID5B RORA	5.50e-05	160	113	5	2798c5bd971407f27dd4d3a4831d63d9c88003c3
ToppCell	Healthy/Control-Treg\|World / Disease group and Cell class	LMCD1 SYNE2 ARID5B RORA PLCL1	5.67e-05	161	113	5	457297cda5c9cee3bcc069fdecbbe24def027e5f
ToppCell	COVID-19_Severe-Treg\|World / disease group, cell group and cell class	RPS6KA5 SYNE2 ARID5B RORA PLCL1	5.67e-05	161	113	5	c6eade2c60c572d823e6e81b5e8d47078671e9b0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIK3R1 SYNE2 RORA PLCL1 CCDC183	5.84e-05	162	113	5	80317c4253bf8e897782e562f29835f181c65b98
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CEP128 PIK3R1 SYNE2 RORA PLCL1	6.01e-05	163	113	5	4dfd408aa700e307478ee35f6b902f68719d8d9e
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	LMCD1 CHST1 RGS16 AGBL3 PLCL1	6.19e-05	164	113	5	67c636a2cc32e56c6186dc7e779cc19af04639d2
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CYTH1 PIK3R1 SYNE2 RORA PLCL1	6.74e-05	167	113	5	83969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ILDR2 EVPL XKR4 PTPRD SYNE2	6.74e-05	167	113	5	c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ILDR2 EVPL XKR4 PTPRD SYNE2	6.74e-05	167	113	5	351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCell	COVID-19_Moderate-Treg\|COVID-19_Moderate / disease group, cell group and cell class	LMCD1 SYNE2 ARID5B RORA PLCL1	6.74e-05	167	113	5	4ddb21421cbe72c06b61dd3a5eb1337e59de42e5
ToppCell	mild_COVID-19-Treg\|World / disease group, cell group and cell class (v2)	LMCD1 SYNE2 ARID5B RORA PLCL1	6.74e-05	167	113	5	69330689b6e353c8ee9ea1b63a5eac6ab38d456f
ToppCell	severe-CD4+_T_naive\|severe / disease stage, cell group and cell class	MAN1C1 CNKSR2 L3MBTL1 LMO7 PLCL1	6.74e-05	167	113	5	02a8215fca59c357c1cdaa5738849eacf98c0bcc
ToppCell	367C-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SCRN3 MYO1D AGBL3 BCLAF3 PIK3R1	6.93e-05	168	113	5	80233a13135fd159f5764336a1fe67fba237776b
ToppCell	severe_influenza-CD4+_CTL\|severe_influenza / disease group, cell group and cell class (v2)	PIK3R1 SYNE2 ARID5B RORA IGSF9B	6.93e-05	168	113	5	50697fda702a09d9a621e9f79c2b52d53792dd2a
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D175\|Adult / Lineage, Cell type, age group and donor	ERG LMCD1 DYRK4 ADGRG6 FAM171A1	7.13e-05	169	113	5	e1f0298236e4a1c59077c14f0dd29a78fac12648
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|390C / Donor, Lineage, Cell class and subclass (all cells)	CYTH2 NUP98 XKR6 ARID5B RORA	7.13e-05	169	113	5	cfc9ff103d13a2d5eacc457e800f53fdd29f7738
ToppCell	COVID-19_Moderate-Treg\|World / disease group, cell group and cell class	LMCD1 SYNE2 ARID5B RORA PLCL1	7.13e-05	169	113	5	27ad11239559b025bef582f89b2a83501d9d3993
ToppCell	normal-na-Lymphocytic_T-T4_em-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	ARID4B PIK3R1 SYNE2 ARID5B RORA	7.54e-05	171	113	5	61318a7aaf3bd8bdd28f8a8614ab4fdf2964b3a3
ToppCell	mild_COVID-19-Treg\|mild_COVID-19 / disease group, cell group and cell class (v2)	LMCD1 SYNE2 ARID5B RORA PLCL1	7.75e-05	172	113	5	77af6324c06b67867e7ce07706536fe38de5ed7b
ToppCell	10x5'-blood-Lymphocytic_Invariant-Inducer-like\|blood / Manually curated celltypes from each tissue	MYO1D DNAH7 SYNE2 RORA CTNND2	8.18e-05	174	113	5	51be6f29308c01593978cbee92114151a5916c9c
ToppCell	Int-URO-Lymphocyte-T_NK-MAIT\|Int-URO / Disease, Lineage and Cell Type	FAM171A1 SYNE2 PLCB1 RORA IGSF9B	8.18e-05	174	113	5	5227ed29f5f0d3e0aaa7f3cfd362f96d3e2660f7
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D231\|Adult / Lineage, Cell type, age group and donor	ERG LMCD1 ADGRG6 FAM171A1 PLCB1	8.18e-05	174	113	5	2dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCell	Healthy_donor-Treg\|Healthy_donor / disease group, cell group and cell class (v2)	LMCD1 SYNE2 ARID5B RORA PLCL1	8.18e-05	174	113	5	1d76921c8404b5be5fbe9f3157d53578033f2ad2
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FAM171A1 LMO7 PIK3R1 PLCB1 PLCL1	8.40e-05	175	113	5	e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCell	10x5'-Lung-Lymphocytic_Invariant-Inducer-like-MAIT\|Lung / Manually curated celltypes from each tissue	MYO1D ATP10B SULT2A1 SYNE2 RORA	8.40e-05	175	113	5	f6663e5a9c87e27f3459a6481768b03aff7d0855
ToppCell	AT1_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	NDST1 EVPL CNKSR2 CTNND2 TUBAL3	8.63e-05	176	113	5	458720776b0151cd55acc352d509599cb62f0ca8
ToppCell	Adult-Endothelial-endothelial_cell_of_vein\|Adult / Lineage, Cell type, age group and donor	ERG LMCD1 ADGRG6 FAM171A1 PLCB1	8.63e-05	176	113	5	043683c61c5d1a7f8a4666a612310246bd3d83a2
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CNKSR2 GRIN1 KCNA2 L3MBTL1 ZNF654	8.87e-05	177	113	5	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	10x5'-Lung-Lymphocytic_Invariant-Inducer-like\|Lung / Manually curated celltypes from each tissue	MYO1D ATP10B SULT2A1 SYNE2 RORA	9.10e-05	178	113	5	bb5dc22f6bcde1ce29598ae4e839e98a7caa07b6
Drug	clofibrate; Up 200; 150uM; MCF7; HG-U133A	HTR1B ZNF318 GRIN1 HUWE1 L3MBTL1 CARD9 OTULINL SNTB1	5.37e-06	194	112	8	263_UP
Drug	Hydrocotarnine hydrobromide [5985-00-2]; Up 200; 13.2uM; PC3; HT_HG-U133A	ERG APC GRIN1 SCML2 PTPRD DYRK1B PLCB1 RORA	6.01e-06	197	112	8	4489_UP
Drug	Methapyrilene hydrochloride [135-23-9]; Up 200; 13.4uM; MCF7; HT_HG-U133A	HTR1B ERG ATP10B HUWE1 ATP10D L3MBTL1 TLN1 KIF1C	6.47e-06	199	112	8	3205_UP
Disease	ovarian cancer (implicated_via_orthology)	POLE APC CTNNB1	2.86e-06	8	111	3	DOID:2394 (implicated_via_orthology)
Disease	prostate cancer (implicated_via_orthology)	POLE APC CHD2 CTNNB1	7.13e-06	33	111	4	DOID:10283 (implicated_via_orthology)
Disease	endometrial carcinoma (is_implicated_in)	POLE APC PIK3R1	1.11e-05	12	111	3	DOID:2871 (is_implicated_in)
Disease	colon adenocarcinoma (implicated_via_orthology)	APC CTNNB1	1.40e-05	2	111	2	DOID:234 (implicated_via_orthology)
Disease	Childhood Medulloblastoma	FLI1 APC SCML2 CTNNB1	2.09e-05	43	111	4	C0278510
Disease	Melanotic medulloblastoma	FLI1 APC SCML2 CTNNB1	2.09e-05	43	111	4	C1275668
Disease	Medullomyoblastoma	FLI1 APC SCML2 CTNNB1	2.09e-05	43	111	4	C0205833
Disease	Desmoplastic Medulloblastoma	FLI1 APC SCML2 CTNNB1	2.09e-05	43	111	4	C0751291
Disease	Adult Medulloblastoma	FLI1 APC SCML2 CTNNB1	2.09e-05	43	111	4	C0278876
Disease	Medulloblastoma	FLI1 APC SCML2 CTNNB1	3.82e-05	50	111	4	C0025149
Disease	Aberrant Crypt Foci	APC CTNNB1	4.20e-05	3	111	2	C1879526
Disease	progressive familial intrahepatic cholestasis (implicated_via_orthology)	ATP10B ATP10D	4.20e-05	3	111	2	DOID:0070221 (implicated_via_orthology)
Disease	glycosyl ceramide (d16:1/24:1, d18:1/22:1) measurement	ATP10D SYNE2	4.20e-05	3	111	2	EFO_0800530
Disease	Fibromatosis, Aggressive	APC CTNNB1	4.20e-05	3	111	2	C0079218
Disease	monoclonal gammopathy	CNKSR2 PTPRD ULK4 RORA	4.82e-05	53	111	4	EFO_0000203
Disease	pathological myopia	FLI1 XKR4 PTPRD CTNND2 SNTB1	6.42e-05	111	111	5	EFO_0004207
Disease	Extra-osseous Ewing's sarcoma	FLI1 ERG	8.37e-05	4	111	2	C0279980
Disease	attention deficit hyperactivity disorder, schizophrenia	HCN1 ARID5B RORA PLCL1	1.01e-04	64	111	4	EFO_0003888, MONDO_0005090
Disease	Epileptic encephalopathy	CHD2 GRIN1 KCNA2	1.95e-04	30	111	3	C0543888
Disease	Corneal astigmatism	FLI1 KCNU1 PIK3R1 CTNND2	2.08e-04	77	111	4	EFO_1002040
Disease	Hepatoblastoma	APC CTNNB1	2.08e-04	6	111	2	C0206624
Disease	Abnormality of refraction	ERG MYO1D HCN1 CNKSR2 CHST1 ULK4 RORA CTNNB1 CTNND2 SNTB1	2.32e-04	673	111	10	HP_0000539
Disease	autism spectrum disorder (implicated_via_orthology)	NDST1 CHD2 GRIN1 CTNNB1 CTNND2	2.81e-04	152	111	5	DOID:0060041 (implicated_via_orthology)
Disease	glycosyl ceramide (d18:1/20:0, d16:1/22:0) measurement	ATP10D SYNE2	2.91e-04	7	111	2	EFO_0800551
Disease	Colorectal Carcinoma	POLE APC HTR3C CNKSR2 WAC PTPRD LMO7 ETAA1 CTNNB1 CTNND2	3.25e-04	702	111	10	C0009402
Disease	endometrial cancer (is_implicated_in)	POLE APC PIK3R1	3.38e-04	36	111	3	DOID:1380 (is_implicated_in)
Disease	Ewings sarcoma	FLI1 ERG	3.87e-04	8	111	2	C0553580
Disease	Adenocarcinoma of large intestine	POLE APC PIK3R1 CTNNB1	4.83e-04	96	111	4	C1319315
Disease	HEPATOCELLULAR CARCINOMA	APC CTNNB1	4.96e-04	9	111	2	114550
Disease	Hepatocellular carcinoma	APC CTNNB1	4.96e-04	9	111	2	cv:C2239176
Disease	Alzheimer disease, APOE carrier status	CHD2 RORA CTNND2 MLPH	5.22e-04	98	111	4	EFO_0007659, MONDO_0004975
Disease	medulloblastoma (is_implicated_in)	APC CTNNB1	6.19e-04	10	111	2	DOID:0050902 (is_implicated_in)
Disease	acute insulin response measurement	CHST1 CARD9	7.54e-04	11	111	2	EFO_0006831
Disease	kidney cancer	CARD9 RORA	7.54e-04	11	111	2	MONDO_0002367
Disease	birth weight, parental genotype effect measurement	SLC38A4 ADGRG6 CNNM3 PIK3R1 RORA	8.13e-04	192	111	5	EFO_0004344, EFO_0005939
Disease	Intestinal Neoplasms	APC CTNNB1	9.03e-04	12	111	2	C0021841
Disease	Intestinal Cancer	APC CTNNB1	9.03e-04	12	111	2	C0346627
Disease	obsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa	HCN1 SYNE2 RORA IGSF9B PLCL1	9.75e-04	200	111	5	EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
Disease	Cocaine-Related Disorders	HTR1B RPS6KA5 GRIN1 TENM3	1.01e-03	117	111	4	C0236736
Disease	Modic type vertebral endplate changes	XKR4 PTPRD	1.06e-03	13	111	2	HP_0030775
Disease	Psychosis, Brief Reactive	HTR1B GRIN1	1.24e-03	14	111	2	C0033958
Disease	unipolar depression, mood disorder, response to antidepressant	ERG PTPRD	1.24e-03	14	111	2	EFO_0003761, EFO_0004247, GO_0036276
Disease	cerebellum cortex volume change measurement	PTPRD PTPRM	1.24e-03	14	111	2	EFO_0021497
Disease	unipolar depression, anxiety	CYTH1 PTPRD	1.24e-03	14	111	2	EFO_0003761, EFO_0005230
Disease	Schizophreniform Disorders	HTR1B GRIN1	1.24e-03	14	111	2	C0036358
Disease	neuroticism measurement, cognitive function measurement	HCN1 APC XKR6 TENM3 RORA IGSF9B PLCL1 CTNND2	1.37e-03	566	111	8	EFO_0007660, EFO_0008354
Disease	Cocaine Abuse	HTR1B RPS6KA5 GRIN1 TENM3	1.37e-03	127	111	4	C0009171
Disease	Opioid use measurement	PTPRD SNTB1	1.43e-03	15	111	2	EFO_0009937
Disease	diffuse idiopathic skeletal hyperostosis	PIK3R1 RORA	1.43e-03	15	111	2	EFO_0007236
Disease	B-cell acute lymphoblastic leukemia	ERG ARID5B	1.43e-03	15	111	2	EFO_0000094
Disease	age-related hearing impairment	ADGRB2 ZNF318 DNAJC2 LMO7 ARID5B PRR14L	1.44e-03	324	111	6	EFO_0005782
Disease	Intellectual Disability	NDST1 APC GRIN1 WAC ADPRS KCNA2 RORA	1.54e-03	447	111	7	C3714756
Disease	nose morphology measurement	MAN1C1 HCN1 ARID5B ETAA1 RORA PLCL1	1.56e-03	329	111	6	EFO_0007843
Disease	blood urea nitrogen measurement	HCN1 SLC38A4 ZNF318 PIK3R1 ARID5B PLCB1 RORA	1.64e-03	452	111	7	EFO_0004741
Disease	Benign neoplasm of stomach	POLE APC	1.84e-03	17	111	2	C0153943
Disease	Eye Abnormalities	NDST1 APC	1.84e-03	17	111	2	C0015393
Disease	Neoplasm of uncertain or unknown behavior of stomach	POLE APC	1.84e-03	17	111	2	C0496905
Disease	Carcinoma in situ of stomach	POLE APC	1.84e-03	17	111	2	C0154060
Disease	Cocaine Dependence	HTR1B RPS6KA5 GRIN1 TENM3	1.91e-03	139	111	4	C0600427
Disease	chronic kidney disease	HCN1 COL6A5 FAM171A1 PTPRM PLCB1	1.98e-03	235	111	5	EFO_0003884
Disease	androstenedione measurement, estrone measurement	PTPRD PTPRM	2.06e-03	18	111	2	EFO_0007970, EFO_0007972
Disease	Malignant neoplasm of endometrium	POLE CTNNB1	2.06e-03	18	111	2	C0007103
Disease	Carcinoma in situ of endometrium	POLE CTNNB1	2.06e-03	18	111	2	C0346191
Disease	aggressive behaviour measurement, ADHD symptom measurement	HCN1 XKR6 PLCL1	2.17e-03	68	111	3	EFO_0007826, EFO_0007860
Disease	physical activity measurement	MYOM3 APC XKR6 RGS16 ARID5B	2.38e-03	245	111	5	EFO_0008002
Disease	pantothenic acid mesurement	ERG PIK3R1	2.55e-03	20	111	2	EFO_0010519
Disease	temporal lobe epilepsy (is_marker_for)	HCN1 CYFIP1	2.55e-03	20	111	2	DOID:3328 (is_marker_for)
Disease	temporal horn of lateral ventricle volume measurement	PTPRM PLCB1 SNTB1	2.56e-03	72	111	3	EFO_0010333
Disease	endometriosis	CNKSR2 XKR6 XKR4 ETAA1 PLCB1	2.68e-03	252	111	5	EFO_0001065
Disease	Stomach Carcinoma	POLE APC	2.81e-03	21	111	2	C0699791
Disease	anxiety disorder (implicated_via_orthology)	HTR1B HCN1	3.08e-03	22	111	2	DOID:2030 (implicated_via_orthology)
Disease	Autistic Disorder	HTR1B MYO1D APC HTR3C RORA	3.12e-03	261	111	5	C0004352
Disease	eosinophilic esophagitis	XKR6 PTPRD RORA SNTB1	3.40e-03	163	111	4	EFO_0004232
Disease	Myopia	FLI1 MYO1D PTPRD ULK4 IGSF9B CTNNB1	3.41e-03	385	111	6	HP_0000545
Disease	alcohol drinking	RORA PLCL1 CTNND2	3.57e-03	81	111	3	EFO_0004329

Protein segments in the cluster

Peptide	Gene	Start	Entry
SKMKIAYKDTPRNRL	nan	76	A8MVM7
MKQLYELSPSRTKRL	ABHD13	276	Q7L211
MGSLERKKLRYSDLD	ADGRB2	1456	O60241
LYKFMEDRGTPINKR	ARID4B	316	Q4LE39
EYSAKRTPKRAAVMI	HTR1B	156	P28222
SRGMRPLFYSEKEAK	AGBL3	236	Q8NEM8
LKDYGDPQGIKRMRS	CEP128	131	Q6ZU80
LLDMYRSAPKEQRDK	RNF20	646	Q5VTR2
NEGRIRYKKPMKVDS	HTR3E	146	A5X5Y0
KLRRDYPSKILMNLS	ADGRG6	891	Q86SQ4
GYTDLREKLKSMTSR	ALKBH5	6	Q6P6C2
SKPNMNYDKLSRALR	ERG	356	P11308
GDSDKLSYSLKKRMP	FAM220BP	21	B1ANY3
SEGRIKYDKPMRVTS	HTR3C	146	Q8WXA8
ALRKDSKMYKDRIEA	CARD9	331	Q9H257
KEALLTYKSDPAMRK	CPA6	211	Q8N4T0
ITKAYEMLSDPVKRR	DNAJC2	141	Q99543
SPREMISLKERKTDY	CTNND2	1076	Q9UQB3
MLDQAPKARKYFERL	DYRK1B	336	Q9Y463
MCELYSKRDTLGLRK	ETNPPL	1	Q8TBG4
MLNNSGPRYKRSKIE	ATP10B	296	O94823
MLNNSGPRYKRSKLE	ATP10D	301	Q9P241
KLPRKMLSRDSSQEY	R3HDM1	131	Q15032
RAYPLDSLEKQMEKA	RABEP2	131	Q9H5N1
ERLDAKMKRLESKYA	CYFIP1	1041	Q7L576
RMSEDKPQDYKKRLS	CTNNB1	661	P35222
LSLRQRKPDEDMKLY	NUP98	1201	P52948
LKARKSMEREGYESS	FAM171A1	466	Q5VUB5
ETLLGDPKKRMRYFD	KCNA2	56	P16389
RDAAPKMYKEEGLKA	SLC25A3	201	Q00325
LLKYRAREPFTKAEM	MAGEA12	121	P43365
RPLERRKYMLKSLDQ	HIPK4	276	Q8NE63
AMRKQSEGLTKEYDR	BCAP31	211	P51572
MKKRKRREYQSPSEE	L3MBTL1	216	Q9Y468
LSYKEAMGRCRKDPL	EVPL	1991	Q92817
NKDPKMSRVALESLY	FRYL	346	O94915
YMSSRRKKKLRPAEI	OPN5	56	Q6U736
ISRDPFYEMLAARKK	CYTH1	376	Q15438
KSKGRKYPEMDLDSR	NDST1	831	P52848
ALKMRELCRTYGKPD	KIF1C	776	O43896
KDDMSYRRISAVEPK	LMO7	291	Q8WWI1
PSYRQKKDDMLTRKI	LMO7	631	Q8WWI1
MPLRASNYTRKELKD	KCNU1	736	A8MYU2
DPNKRLKMSGLRYNE	RPS6KA5	671	O75582
NRSMSRKLEDYGEQK	POLE	1036	Q07864
YREIDKRMNSIKPDL	PIK3R1	556	P27986
YRELHRKSPEEMKNR	HUWE1	4031	Q7Z6Z7
DRKIGRLLMDSKYST	LMCD1	66	Q9NZU5
GETPRNKLMRKAYEE	OTULINL	106	Q9NUU6
RYETPKRALKMDSLS	ETAA1	76	Q9NY74
RGKKRYPDSKDLTMV	DYRK4	351	Q9NR20
KYLKALDTRMAAESR	CENPB	276	P07199
ETMDNKKGRRYEAVK	CLCN6	66	P51797
KGMDSEVYKTARALR	HCN1	241	O60741
RLMRKKKEYTDVATG	BCLAF3	696	A2AJT9
EIYMLPRIRSSTKKA	CHD2	1066	O14647
EADKKAARSKPYAMR	GJC1	106	P36383
YSFPKDRMKTVERNL	GALNT5	731	Q7Z7M9
RSTLRKLKPESMYET	CASQ1	261	P31415
IRRAINKYPTEDMKA	COL6A5	2491	A8TX70
SVDPFYEMLAARKKR	CYTH2	376	Q99418
ETEKKIDTTRMGYRP	DNAH7	3191	Q8WXX0
SKPNMNYDKLSRALR	FLI1	326	Q01543
DVYRQKSRKLISDMG	HYAL4	161	Q2M3T9
KETSEKYRRGQMDLD	CCDC183	256	Q5T5S1
GMEERPYSSRLKKIG	ADPRS	236	Q9NX46
RYAMGKNELRPLTKD	MAN1C1	191	Q9NR34
YKDKLPDSGDSMLRI	CEP192	701	Q8TEP8
APYERRAMELLKVSK	RPL36	51	Q9Y3U8
YFKMLSRKLAQLPDR	SEC22A	36	Q96IW7
PNADSKKRIRMDSYT	SLC20A1	451	Q8WUM9
SEAKAMAVPYLLRRK	MLPH	536	Q9BV36
SSELLPMAKSYKRLR	PRR14L	1641	Q5THK1
DSAKKDENRMKNRYG	PTPRM	916	P28827
YRLKFGRKDMEPLTT	PTPRD	856	P23468
KDLLIYDSMPRRKEA	SNTB1	351	Q13884
KSSPSYAMRRKIEEI	SYNE2	3681	Q8WXH0
KALETMNKYDLSGRP	MYEF2	156	Q9P2K5
LNFMEKRIDKGSSYR	RIC8B	346	Q9NVN3
IAREHPDMRNYAKRK	SCRN3	196	Q0VDG4
DMNEYLLSRKPNRKT	PDIK1L	126	Q8N165
NKMLRRSDSPENKYS	WAC	56	Q9BTA9
MERLTGEYSRKTKLE	TUBAL3	161	A6NHL2
SSKAKVIYLMRNPRD	SULT2A1	111	Q06520
PIYSELKDRSRRKMQ	SLC38A4	351	Q969I6
RYRSMLKRIQDKPSS	ARID5B	186	Q14865
LRNLMANRPAKYKDA	APC	726	P25054
RYEDLARNPMKKTEE	CHST1	301	O43916
DYEDPNKMKRDSRRE	CNKSR2	451	Q8WXI2
YRDTVVKRKPASLMA	CNNM3	456	Q8NE01
LEKQMEDAYRGTKRK	NKAPD1	36	Q6ZUT1
EDAYRGTKRKMLPSS	NKAPD1	41	Q6ZUT1
LDPSQKKLYRDVMRE	ZNF564	21	Q8TBZ8
KKFLSRIYPSAMRID	PLCL1	636	Q15111
LLRDSRDDKKSMSYR	XKR6	341	Q5GH73
RDDKKSMSYRGAIIQ	XKR6	346	Q5GH73
LARMATRKAKPDGQY	REV1	616	Q9UBZ9
KRMLSPTREKELSLY	IGSF9B	806	Q9UPX0
GRMSKKQRDSLYAEV	RORA	146	P35398
LKSLTRDRGMLYKDV	SCML2	331	Q9UQR0
KGYRIQADKERDSMK	ILDR2	296	Q71H61
GDTMEYRKKQRPLKI	TLN1	76	Q9Y490
RYMKHKRDDGPEKQE	SPPL2B	201	Q8TCT7
LDERYLSMPKRRKFL	ZNF654	1056	Q8IZM8
ALRDSRDDKKPISYM	XKR4	356	Q5GH76
METRYNLKSPAVKRL	UBE2J1	1	Q9Y385
MDVKERRPYCSLTKS	TENM3	1	Q9P273
MDSATAPDKIRKLYL	ACP6	316	Q9NPH0
QGKTRTLMEKDSYPR	RGS16	156	O15492
KMQLSRIYPKGTRVD	PLCB1	591	Q9NQ66
MADPRDKALQDYRKK	PSMC6	1	P62333
SRAAEKLYLADPMKA	SRP9	11	P49458
AKRPRYDDTVKINSM	ZNF318	271	Q5VUA4
VMYIERDSRKTTPGK	ULK4	776	Q96C45
IADAAYKAMKRRSKD	MYO1D	81	O94832
KKDKGIYRAMVSDDR	MYOM3	1181	Q5VTT5
TEKPRGYQMSTRLKI	GRIN1	386	Q05586