Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontetrahydrofolyl-poly(glutamate) polymer binding

FOLH1 FOLH1B

8.58e-062592GO:1904493
GeneOntologyMolecularFunctionAc-Asp-Glu binding

FOLH1 FOLH1B

8.58e-062592GO:1904492
GeneOntologyMolecularFunction5'-nucleotidase activity

NT5DC4 ACP3 NT5C2

1.09e-0515593GO:0008253
GeneOntologyMolecularFunctionacyltransferase activity

ACSM3 KAT5 NEDD4L FBXO3 DZIP3 NT5C2 HMGCS1 TMEM68 HERC4 UBE2Z NEDD4

1.43e-057755911GO:0016746
GeneOntologyMolecularFunctionnucleotidase activity

NT5DC4 ACP3 NT5C2

1.94e-0518593GO:0008252
GeneOntologyMolecularFunctionUDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity

B4GALT6 B4GALT5

2.57e-053592GO:0008489
GeneOntologyMolecularFunctionpropionate-CoA ligase activity

ACSM3 ACSS3

5.13e-054592GO:0050218
GeneOntologyMolecularFunctionshort-chain fatty acid-CoA ligase activity

ACSM3 ACSS3

5.13e-054592GO:0031955
GeneOntologyMolecularFunctionsodium channel inhibitor activity

NEDD4L NEDD4

2.38e-048592GO:0019871
GeneOntologyMolecularFunctionXMP 5'-nucleosidase activity

ACP3 NT5C2

2.38e-048592GO:0106411
GeneOntologyMolecularFunctionexopeptidase activity

GGH FOLH1 FOLH1B ENPEP

3.14e-04110594GO:0008238
GeneOntologyMolecularFunctionmedium-chain fatty acid-CoA ligase activity

ACSM3 ACSS3

4.64e-0411592GO:0031956
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

NEDD4L FBXO3 DZIP3 NT5C2 HERC4 UBE2Z NEDD4

4.71e-04473597GO:0004842
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

NEDD4L FBXO3 DZIP3 NT5C2 HERC4 UBE2Z NEDD4

7.53e-04512597GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

NEDD4L FBXO3 DZIP3 NT5C2 HERC4 UBE2Z NEDD4

9.42e-04532597GO:0016755
GeneOntologyMolecularFunctionmetalloexopeptidase activity

FOLH1 FOLH1B ENPEP

1.17e-0370593GO:0008235
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH12 DNAH6

1.27e-0318592GO:0008569
GeneOntologyMolecularFunctiondipeptidase activity

FOLH1 FOLH1B

1.27e-0318592GO:0016805
GeneOntologyMolecularFunctionphosphatase activity

PTPDC1 NT5DC4 ACP3 NT5C2 CDC25B

1.57e-03287595GO:0016791
GeneOntologyMolecularFunctionoligopeptide binding

FOLH1 FOLH1B

1.58e-0320592GO:1900750
GeneOntologyMolecularFunctioncysteine-type peptidase activity

GGH USP34 ATG4C USP47

2.50e-03192594GO:0008234
GeneOntologyMolecularFunctionfatty acid ligase activity

ACSM3 ACSS3

2.67e-0326592GO:0015645
GeneOntologyMolecularFunctionCoA-ligase activity

ACSM3 ACSS3

2.87e-0327592GO:0016405
GeneOntologyMolecularFunctionpeptidase activity

GGH USP34 FOLH1 FOLH1B ATG4C ENPEP USP47

3.05e-03654597GO:0008233
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH12 DNAH6

3.09e-0328592GO:0051959
GeneOntologyMolecularFunctionhexosyltransferase activity

B3GALT9 B4GALT6 B4GALT5 PIGM

3.50e-03211594GO:0016758
GeneOntologyMolecularFunctionprotein tyrosine phosphatase activity

PTPDC1 ACP3 CDC25B

3.51e-03103593GO:0004725
GeneOntologyMolecularFunctionacid-thiol ligase activity

ACSM3 ACSS3

3.78e-0331592GO:0016878
GeneOntologyMolecularFunctionmetallocarboxypeptidase activity

FOLH1 FOLH1B

3.78e-0331592GO:0004181
GeneOntologyMolecularFunctionUDP-galactosyltransferase activity

B4GALT6 B4GALT5

4.02e-0332592GO:0035250
GeneOntologyMolecularFunctiongalactosyltransferase activity

B4GALT6 B4GALT5

4.80e-0335592GO:0008378
GeneOntologyMolecularFunctionubiquitin protein ligase activity

NEDD4L DZIP3 NT5C2 HERC4 NEDD4

4.80e-03372595GO:0061630
GeneOntologyMolecularFunctiontranscription regulator inhibitor activity

TRAPPC2B TRAPPC2

5.07e-0336592GO:0140416
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH12 DNAH6

5.35e-0337592GO:0045505
GeneOntologyMolecularFunctionphosphoric ester hydrolase activity

PTPDC1 NT5DC4 ACP3 NT5C2 CDC25B

5.60e-03386595GO:0042578
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

NEDD4L DZIP3 NT5C2 HERC4 NEDD4

6.36e-03398595GO:0061659
GeneOntologyMolecularFunctionligase activity, forming carbon-sulfur bonds

ACSM3 ACSS3

6.54e-0341592GO:0016877
GeneOntologyMolecularFunctionsodium channel regulator activity

NEDD4L NEDD4

7.50e-0344592GO:0017080
GeneOntologyMolecularFunctionion channel inhibitor activity

NEDD4L NEDD4

8.87e-0348592GO:0008200
GeneOntologyMolecularFunctioncarboxypeptidase activity

FOLH1 FOLH1B

9.23e-0349592GO:0004180
GeneOntologyBiologicalProcesspost-translational protein modification

USP34 NEDD4L FBXO3 FOLH1 NQO1 DZIP3 NT5C2 FOLH1B ATG4C HERC4 UBE2Z USP47 NEDD4

5.54e-0610745713GO:0043687
GeneOntologyBiologicalProcessadenosine metabolic process

ACP3 NT5C2 ADA2

1.59e-0518573GO:0046085
GeneOntologyBiologicalProcessC-terminal protein amino acid modification

FOLH1 FOLH1B ATG4C

1.88e-0519573GO:0018410
GeneOntologyBiologicalProcesspurine ribonucleoside metabolic process

ACP3 NT5C2 ADA2

9.38e-0532573GO:0046128
GeneOntologyBiologicalProcessganglioside biosynthetic process via lactosylceramide

B4GALT6 B4GALT5

1.12e-046572GO:0010706
GeneOntologyBiologicalProcessC-terminal protein deglutamylation

FOLH1 FOLH1B

1.12e-046572GO:0035609
GeneOntologyBiologicalProcessfolic acid-containing compound metabolic process

GGH FOLH1 FOLH1B

1.13e-0434573GO:0006760
GeneOntologyBiologicalProcesspurine nucleoside metabolic process

ACP3 NT5C2 ADA2

1.45e-0437573GO:0042278
GeneOntologyBiologicalProcesspteridine-containing compound metabolic process

GGH FOLH1 FOLH1B

1.84e-0440573GO:0042558
GeneOntologyBiologicalProcessprotein deglutamylation

FOLH1 FOLH1B

2.08e-048572GO:0035608
GeneOntologyBiologicalProcesssodium ion transmembrane transport

NEDD4L SCN10A SLC6A15 ATP1B2 NEDD4

2.72e-04208575GO:0035725
GeneOntologyBiologicalProcessribonucleoside metabolic process

ACP3 NT5C2 ADA2

3.17e-0448573GO:0009119
GeneOntologyBiologicalProcessregulation protein catabolic process at postsynapse

NEDD4L NEDD4

3.33e-0410572GO:0140252
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

USP34 NEDD4L FBXO3 NQO1 DZIP3 NT5C2 HERC4 UBE2Z USP47 NEDD4

3.98e-0410095710GO:0070647
GeneOntologyBiologicalProcessamide metabolic process

ACSM3 NT5C2 ACOT1 HMGCS1 ENPEP B4GALT6 B4GALT5

4.98e-04511577GO:0043603
GeneOntologyCellularComponentinner dynein arm

DNAH12 DNAH6

3.36e-0410582GO:0036156
GeneOntologyCellularComponentTRAPPII protein complex

TRAPPC2B TRAPPC2

4.91e-0412582GO:1990071
GeneOntologyCellularComponentTRAPPIII protein complex

TRAPPC2B TRAPPC2

4.91e-0412582GO:1990072
GeneOntologyCellularComponentTRAPP complex

TRAPPC2B TRAPPC2

1.00e-0317582GO:0030008
DomainHECT

NEDD4L HERC4 NEDD4

6.36e-0527543PF00632
DomainHECTc

NEDD4L HERC4 NEDD4

6.36e-0527543SM00119
DomainHECT_dom

NEDD4L HERC4 NEDD4

6.36e-0527543IPR000569
DomainHECT

NEDD4L HERC4 NEDD4

6.36e-0527543PS50237
DomainTFR_dimer

FOLH1 FOLH1B

1.22e-046542PF04253
Domain-

FOLH1 FOLH1B

1.22e-0465421.20.930.40
DomainGalactosyl_T

B4GALT6 B4GALT5

1.71e-047542IPR003859
DomainGalactosyl_T_C

B4GALT6 B4GALT5

1.71e-047542IPR027791
DomainGalactosyl_T_N

B4GALT6 B4GALT5

1.71e-047542IPR027995
DomainTFR-like_dimer_dom

FOLH1 FOLH1B

1.71e-047542IPR007365
DomainGlyco_transf_7C

B4GALT6 B4GALT5

1.71e-047542PF02709
DomainGlyco_transf_7N

B4GALT6 B4GALT5

1.71e-047542PF13733
DomainPeptidase_M28

FOLH1 FOLH1B

5.32e-0412542PF04389
DomainPeptidase_M28

FOLH1 FOLH1B

5.32e-0412542IPR007484
DomainATPase_dyneun-rel_AAA

DNAH12 DNAH6

7.30e-0414542IPR011704
DomainDynein_heavy_chain_D4_dom

DNAH12 DNAH6

7.30e-0414542IPR024317
DomainDynein_heavy_dom-2

DNAH12 DNAH6

7.30e-0414542IPR013602
DomainDHC_N2

DNAH12 DNAH6

7.30e-0414542PF08393
DomainAAA_8

DNAH12 DNAH6

7.30e-0414542PF12780
DomainAAA_5

DNAH12 DNAH6

7.30e-0414542PF07728
DomainDHC_fam

DNAH12 DNAH6

8.41e-0415542IPR026983
DomainDynein_heavy_dom

DNAH12 DNAH6

8.41e-0415542IPR004273
DomainDynein_heavy

DNAH12 DNAH6

8.41e-0415542PF03028
DomainAMP-bd_C

ACSM3 ACSS3

1.09e-0317542IPR025110
DomainAMP-binding_C

ACSM3 ACSS3

1.09e-0317542PF13193
DomainAMP-binding_CS

ACSM3 ACSS3

2.55e-0326542IPR020845
DomainAMP_BINDING

ACSM3 ACSS3

2.96e-0328542PS00455
DomainAMP-binding

ACSM3 ACSS3

3.39e-0330542PF00501
DomainAMP-dep_Synth/Lig

ACSM3 ACSS3

3.39e-0330542IPR000873
DomainWW

NEDD4L NEDD4

8.16e-0347542PF00397
DomainWW

NEDD4L NEDD4

8.50e-0348542SM00456
DomainWW_DOMAIN_2

NEDD4L NEDD4

9.56e-0351542PS50020
DomainWW_DOMAIN_1

NEDD4L NEDD4

9.56e-0351542PS01159
DomainWW_dom

NEDD4L NEDD4

9.92e-0352542IPR001202
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

NEDD4L SCN10A NEDD4

1.38e-061360315123669
Pubmed

Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation.

NEDD4L NEDD4

2.93e-06260211502596
Pubmed

Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate.

FOLH1 FOLH1B

2.93e-06260212358725
Pubmed

Mice lacking glutamate carboxypeptidase II develop normally, but are less susceptible to traumatic brain injury.

FOLH1 FOLH1B

2.93e-06260225872793
Pubmed

β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5.

B4GALT6 B4GALT5

2.93e-06260223882130
Pubmed

Glutamate carboxypeptidase II gene knockout attenuates oxidative stress and cortical apoptosis after traumatic brain injury.

FOLH1 FOLH1B

2.93e-06260227091009
Pubmed

Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs.

B4GALT6 B4GALT5

2.93e-06260224498430
Pubmed

Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen.

FOLH1 FOLH1B

2.93e-0626028417812
Pubmed

Expression pattern of mouse homolog of prostate-specific membrane antigen (FOLH1) in the transgenic adenocarcinoma of the mouse prostate model.

FOLH1 FOLH1B

2.93e-06260212712410
Pubmed

GCPII Inhibition Promotes Remyelination after Peripheral Nerve Injury in Aged Mice.

FOLH1 FOLH1B

2.93e-06260239000003
Pubmed

Nedd4 and Nedd4-2: ubiquitin ligases at work in the neuron.

NEDD4L NEDD4

2.93e-06260223262292
Pubmed

A novel PSMA/GCPII-deficient mouse model shows enlarged seminal vesicles upon aging.

FOLH1 FOLH1B

2.93e-06260230256431
Pubmed

Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2.

NEDD4L NEDD4

2.93e-06260219602703
Pubmed

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.

NEDD4L NEDD4

2.93e-06260211149908
Pubmed

Dietary sodium modulates nephropathy in Nedd4-2-deficient mice.

NEDD4L NEDD4

2.93e-06260231802037
Pubmed

Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction.

FOLH1 FOLH1B

2.93e-06260216809768
Pubmed

Metabolite differences between glutamate carboxypeptidase II gene knockout mice and their wild-type littermates after traumatic brain injury: a 7-tesla 1H-MRS study.

FOLH1 FOLH1B

2.93e-06260230458729
Pubmed

Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene.

FOLH1 FOLH1B

2.93e-06260214716746
Pubmed

Detailed genetic mapping around a putative prostate-specific membrane antigen locus on human chromosome 11p11.2.

FOLH1 FOLH1B

2.93e-0626029691167
Pubmed

Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not.

TRAPPC2B TRAPPC2

2.93e-06260214597397
Pubmed

Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda.

TRAPPC2B TRAPPC2

2.93e-06260210431248
Pubmed

Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.

NEDD4L NEDD4

2.93e-06260237962894
Pubmed

Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis.

FOLH1 FOLH1B

2.93e-06260223169655
Pubmed

Distinguishing Plasmodium falciparum treatment failures from reinfections by restrictions fragment length polymorphism and polymerase chain reaction genotyping.

FOLH1 FOLH1B

2.93e-0626029347959
Pubmed

Early embryonic death of glutamate carboxypeptidase II (NAALADase) homozygous mutants.

FOLH1 FOLH1B

2.93e-06260214556233
Pubmed

Glutamate carboxypeptidase II and folate deficiencies result in reciprocal protection against cognitive and social deficits in mice: implications for neurodevelopmental disorders.

FOLH1 FOLH1B

2.93e-06260222076974
Pubmed

Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene.

FOLH1 FOLH1B

2.93e-0626029838072
Pubmed

Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400).

TRAPPC2B TRAPPC2

2.93e-06260212939648
Pubmed

Cloning, expression, genomic localization, and enzymatic activities of the mouse homolog of prostate-specific membrane antigen/NAALADase/folate hydrolase.

FOLH1 FOLH1B

2.93e-06260211210180
Pubmed

Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice.

B4GALT6 B4GALT5

2.93e-06260230114188
Pubmed

Mice lacking glutamate carboxypeptidase II are protected from peripheral neuropathy and ischemic brain injury.

FOLH1 FOLH1B

2.93e-06260216190866
Pubmed

Phenotypic characterization of mice heterozygous for a null mutation of glutamate carboxypeptidase II.

FOLH1 FOLH1B

2.93e-06260219347959
Pubmed

RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.

NEDD4L DZIP3 NEDD4

3.26e-061760328292929
Pubmed

Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain.

NEDD4L NEDD4

8.77e-06360218498246
Pubmed

Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.

NEDD4L NEDD4

8.77e-06360221852580
Pubmed

Prostate specific membrane antigen (PSMA) regulates angiogenesis independently of VEGF during ocular neovascularization.

FOLH1 FOLH1B

8.77e-06360222815987
Pubmed

The high-affinity choline transporter CHT1 is regulated by the ubiquitin ligase Nedd4-2.

NEDD4L NEDD4

8.77e-06360222361880
Pubmed

Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination.

NEDD4L NEDD4

8.77e-06360215217910
Pubmed

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.

B4GALT6 B4GALT5

8.77e-06360225216636
Pubmed

Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C.

NEDD4L NEDD4

8.77e-06360219423771
Pubmed

Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.

NEDD4L NEDD4

8.77e-06360212050153
Pubmed

Biochemical characterization of human glutamate carboxypeptidase III.

FOLH1 FOLH1B

8.77e-06360217241121
Pubmed

Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation.

NEDD4L NEDD4

8.77e-06360220730100
Pubmed

Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1.

NEDD4L NEDD4

8.77e-06360226823285
Pubmed

Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy.

NEDD4L NEDD4

8.77e-06360223686771
Pubmed

Molecular evolution of the transferrin receptor/glutamate carboxypeptidase II family.

FOLH1 FOLH1B

8.77e-06360217160644
Pubmed

Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long-term benefits in mice with traumatic brain injury.

FOLH1 FOLH1B

8.77e-06360237349952
Pubmed

Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition.

FOLH1 FOLH1B

8.77e-06360238377674
Pubmed

Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.

NEDD4L NEDD4

8.77e-06360211779188
Pubmed

Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3.

FOLH1 FOLH1B

8.77e-06360221908619
Pubmed

Characterization of the interactions between Nedd4-2, ENaC, and sgk-1 using surface plasmon resonance.

NEDD4L NEDD4

8.77e-06360212729930
Pubmed

14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.

NEDD4L NEDD4

8.77e-06360215677482
Pubmed

Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice.

SLC26A3 FOLH1 FOLH1B

9.63e-062460328818950
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

NEDD4L HERC4 NEDD4

1.23e-052660326949039
Pubmed

SGK1/Nedd4-2 signaling pathway regulates the activity of human organic anion transporters 3.

NEDD4L NEDD4

1.75e-05460228608480
Pubmed

The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.

NEDD4L NEDD4

1.75e-05460220026598
Pubmed

C2-lacking isoform of Nedd4-2 regulates excitatory synaptic strength through GluA1 ubiquitination-independent mechanisms.

NEDD4L NEDD4

1.75e-05460231357244
Pubmed

A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1.

TRAPPC2B TRAPPC2

1.75e-05460211134351
Pubmed

Kir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron.

NEDD4L NEDD4

1.75e-05460229897283
Pubmed

The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation.

NEDD4L NEDD4

1.75e-05460227466427
Pubmed

GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2.

NEDD4L NEDD4

1.75e-05460217544362
Pubmed

Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli.

NEDD4L SCN10A

1.75e-05460227604420
Pubmed

NEDD4-2 associates with gamma(c) and regulates its degradation rate.

NEDD4L NEDD4

1.75e-05460219615332
Pubmed

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels.

NEDD4L NEDD4

1.75e-05460222024150
Pubmed

Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.

NEDD4L NEDD4

1.75e-05460211696533
Pubmed

Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1.

NEDD4L NEDD4

1.75e-05460221463633
Pubmed

PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer.

FOLH1 FOLH1B

2.92e-05560228292957
Pubmed

Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly.

NEDD4L NEDD4

2.92e-05560230287686
Pubmed

An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel.

NEDD4L NEDD4

2.92e-05560218687683
Pubmed

Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.

NEDD4L NEDD4

2.92e-05560221478478
Pubmed

The ESCRT pathway and HIV-1 budding.

NEDD4L NEDD4

2.92e-05560219143627
Pubmed

Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway.

NEDD4L NEDD4

2.92e-05560219617352
Pubmed

Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.

NEDD4L NEDD4

2.92e-05560225631046
Pubmed

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.

NEDD4L NEDD4

2.92e-05560217289006
Pubmed

Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.

NEDD4L NEDD4

2.92e-05560215548568
Pubmed

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.

NEDD4L NEDD4

2.92e-05560225157163
Pubmed

Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis.

NEDD4L NEDD4

2.92e-05560227793840
Pubmed

The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation.

NEDD4L NEDD4

2.92e-05560222385262
Pubmed

NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.

NEDD4L NEDD4

2.92e-05560231867777
Pubmed

Identification of a Spinal Circuit for Mechanical and Persistent Spontaneous Itch.

TLR5 SCN10A

2.92e-05560231324538
Pubmed

A Nedd4 E3 Ubiquitin Ligase Pathway Inhibits Robo1 Repulsion and Promotes Commissural Axon Guidance across the Midline.

NEDD4L NEDD4

2.92e-05560236002265
Pubmed

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.

NEDD4L NEDD4

2.92e-05560219706893
Pubmed

Inactivation of Fgf3 and Fgf4 within the Fgf3/Fgf4/Fgf15 gene cluster reveals their redundant requirement for mouse inner ear induction and embryonic survival.

FGF4 FOXG1

2.92e-05560234719815
Pubmed

The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels.

NEDD4L NEDD4

2.92e-05560218577513
Pubmed

N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.

NEDD4L NEDD4

4.37e-05660215252135
Pubmed

Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).

NEDD4L NEDD4

4.37e-05660227445338
Pubmed

Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination.

NEDD4L NEDD4

4.37e-05660216701206
Pubmed

Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3.

NEDD4L NEDD4

4.37e-05660226854353
Pubmed

β-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.

NEDD4L NEDD4

4.37e-05660229964046
Pubmed

The expanding beta 4-galactosyltransferase gene family: messages from the databanks.

B4GALT6 B4GALT5

4.37e-0566029597550
Pubmed

Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice.

NEDD4L NEDD4

4.37e-05660237156795
Pubmed

N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.

NEDD4L NEDD4

4.37e-05660211748237
Pubmed

A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.

NEDD4L NEDD4

6.11e-05760230587574
Pubmed

Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.

NEDD4L NEDD4

6.11e-05760220051513
Pubmed

HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.

NEDD4L NEDD4

6.11e-05760220086093
Pubmed

Systematic discovery of nonobvious human disease models through orthologous phenotypes.

FOLH1 FOLH1B

6.11e-05760220308572
Pubmed

Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.

NEDD4L NEDD4

6.11e-05760224831002
Pubmed

Functional organization of the yeast proteome by systematic analysis of protein complexes.

TRAPPC2B TRAPPC2

6.11e-05760211805826
Pubmed

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.

NEDD4L NEDD4

6.11e-05760211046148
Pubmed

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.

NEDD4L NEDD4

6.11e-05760223644597
InteractionSCN10A interactions

NEDD4L SCN10A NEDD4

3.48e-0611573int:SCN10A
InteractionCLIC2 interactions

NEDD4L NEDD4 TRAPPC2

2.36e-0520573int:CLIC2
GeneFamilyDyneins, axonemal

DNAH12 DNAH6

6.04e-0417392536
GeneFamilyBeta 4-glycosyltransferases

B4GALT6 B4GALT5

6.04e-0417392425
GeneFamilyAcyl-CoA synthetase family

ACSM3 ACSS3

1.43e-032639240
GeneFamilyUbiquitin specific peptidases

USP34 USP47

6.49e-0356392366
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 NQO1 DZIP3 DNAH6 HYDIN

2.10e-07189606b4b93bd10b7e3cc16e54ff73beac230f519c010a
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 NQO1 DZIP3 DNAH6 HYDIN

2.45e-071946063cd90d01ed5a5ce65aad8284dab2537ec16e3d7c
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 NQO1 DZIP3 DNAH6 HYDIN

2.45e-07194606a46238514bca920c3e3713d23c18ba24a09e2a29
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 NQO1 DZIP3 DNAH6 HYDIN

2.53e-07195606db4270c135c392ed443670981656e3cd5b95939d
ToppCellNS-critical-d_07-13-Epithelial-Ciliated-diff|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH12 TEX26 NQO1 DZIP3 DNAH6 HYDIN

2.69e-0719760632484fb5dde0a4525dd8028dde01ca5a4e51e4b6
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 NQO1 DZIP3 DNAH6 HYDIN

2.69e-0719760687db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 NQO1 DZIP3 DNAH6 HYDIN

2.69e-0719760691637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 NQO1 DZIP3 DNAH6 HYDIN

2.69e-0719760622c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 NQO1 DZIP3 DNAH6 HYDIN

2.69e-071976063bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 NQO1 DZIP3 HYDIN

4.43e-06180605adf5db5bfa9a38b1227ab0beccd8d6f3eea67ac0
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 NQO1 DNAH6 HYDIN

4.43e-061806051f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 NQO1 DNAH6 HYDIN

5.91e-06191605683e5c7e6173644f01e67c98ab7b75d7cb9cce99
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DNAH12 NQO1 DZIP3 DNAH6 HYDIN

6.06e-0619260503acd4a26b986e34eee608747347791122f1aa52
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DNAH12 NQO1 DZIP3 DNAH6 HYDIN

6.06e-0619260531c6046589e2fbb0486fd044c5b128099d37872f
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 DZIP3 DNAH6 HYDIN

6.22e-06193605e1b76102f812c433195d1e8811fdd3293a7bc22e
ToppCell15-Trachea-Epithelial-Multiciliated_cell|Trachea / Age, Tissue, Lineage and Cell class

DNAH12 TEX26 DZIP3 DNAH6 HYDIN

6.22e-06193605aa3acc7571405169efb656d214f3a8cbf988362e
ToppCellBronchial_Brush-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

DNAH12 NQO1 DZIP3 DNAH6 HYDIN

6.38e-061946057a7ddccfe72a4a0dc4d1a5c809988f0069f9f1a3
ToppCellBronchial_Brush-Epithelial-Ciliated_1|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

DNAH12 NQO1 DZIP3 DNAH6 HYDIN

6.38e-06194605b4ce60c06568123008b1081d644733cb91c28f51
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 DZIP3 DNAH6 HYDIN

6.54e-0619560593b1559382a12cfb158aa5fac7386e38b4f87989
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 NQO1 DZIP3 DNAH6 HYDIN

6.54e-06195605649fd2336e963f6a150d182a53ad5dd838ca80b1
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 NQO1 DZIP3 DNAH6 HYDIN

6.54e-0619560579dc031258579ea328181dda33710dd897f1064a
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 NQO1 DZIP3 HYDIN

6.54e-06195605d211a836cf711fdb91b10d512f09d462be937cc5
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 DZIP3 DNAH6 HYDIN

6.54e-061956050e763f36786515698b593e5c93f6a56619c1242d
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 NQO1 DZIP3 DNAH6 HYDIN

6.54e-06195605129ad5f4253ecb1a8477cc38773e6e91ea9570b0
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 NQO1 DZIP3 DNAH6 HYDIN

6.54e-061956053e70ee987d66d450062d5df3d7c733ccc7344470
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 NQO1 DZIP3 DNAH6 HYDIN

6.54e-061956056365e3893e38231090ec2dbef010dec71dea3d07
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 DZIP3 DNAH6 HYDIN

6.54e-06195605581b04220587e1d5198b1abd6965965ace7803e7
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated-diff|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH12 TEX26 NQO1 DNAH6 HYDIN

6.70e-061966059a91a6e5f93ce3bb5a0fc63677553f4c2df95c43
ToppCellNS-critical-d_0-4-Epithelial-Ciliated-diff|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH12 TEX26 NQO1 DZIP3 HYDIN

6.87e-0619760562e20ef825b92908d7732aa625dcff7b95ef6ca8
ToppCellSubstantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC26A3 DNAH12 DNAH6 HYDIN

3.42e-0513660467d736096d6b6ddb4722809557f5e987063b8d23
ToppCellSubstantia_nigra-Macroglia-CSF_related|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC26A3 DNAH12 DNAH6 HYDIN

3.42e-0513660447663c5d81c766a333207a44fc5b58b07309ee76
ToppCellSubstantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)--|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC26A3 DNAH12 DNAH6 HYDIN

3.42e-051366046d2e5b871f4cf8d64e6fe0be666fb3490797c635
ToppCellSubstantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC26A3 DNAH12 DNAH6 HYDIN

3.42e-05136604fd4269d194c7c11c6ab4383393a01efab05cbace
ToppCellSubstantia_nigra-Macroglia-CSF_related-EPENDYMAL|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC26A3 DNAH12 DNAH6 HYDIN

3.42e-051366043f6cec8d52c84191f7f6e2dd4dc47524dfd5b21b
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

DNAH12 NEDD4L DNAH6 HYDIN

5.14e-051516048216462e723fec2797387929dde095370947e10a
ToppCellCiliated_cells-B-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

DNAH12 TEX26 DNAH6 HYDIN

7.08e-051646040e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACSM3 HYKK NQO1 ACOT1

7.25e-05165604082f62f759a0b16ab56fad6dd4c4dd70b4f18a5c
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACSM3 HYKK NQO1 ACOT1

7.42e-051666040868f45d8d39ad39b5cee5e81ac3dd4dc512775d
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FBXO3 ATP1B2 HYDIN TRAPPC2

7.59e-051676043b717d33aaf1ef0869cc4bca8432ba8008875cc5
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACSM3 HYKK SLC6A15 B4GALT5

7.77e-0516860435ce3b2b9c9997d4c101da5949c7271d6a6b8f12
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DNAH12 NQO1 DNAH6 HYDIN

7.77e-051686049a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 DZIP3 DNAH6 HYDIN

7.95e-0516960414aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_ventral_progenitors|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

NEDD4L OVOS2 CDC25B FOXG1

8.13e-0517060473601c873b177d5d134618d8e228c51381119f7d
ToppCelldroplet-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACSM3 HYKK HMGCS1 B4GALT5

8.32e-0517160405fcc72df50a380a913821b5781d9621df37d328
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACSM3 HYKK HMGCS1 B4GALT5

8.32e-0517160448fc4eca18b102b5ec5050f758281292ee8e10c6
ToppCellCiliated_cells-B-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

DNAH12 TEX26 DZIP3 HYDIN

8.51e-05172604187ae91148d293537afc77e10da2b64302322224
ToppCelldroplet-Lung-nan-3m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPDC1 HEBP1 TLR5 ACOT1

9.72e-05178604de6cd81e6d58e7687386df163471bf1901b9c0aa
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-VLMC-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NEDD4L HEBP1 NQO1 ACOT1

9.93e-05179604381ac15d59f31bc613828bdcfbc9192b106b4d18
ToppCell(05)_Ciliated-(4)_1wkpi|(05)_Ciliated / shred by cell type and Timepoint

USP34 DNAH12 TEX26 ACOT1

1.01e-0418060485fc9b164147b28545e2397d32302eea03ef6346
ToppCell368C-Epithelial_cells-Epithelial-F_(Ciliated)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DNAH12 DZIP3 DNAH6 HYDIN

1.06e-04182604f8c28fa76751062c4cfba0db8af1b377f947f739
ToppCell368C-Epithelial_cells-Epithelial-F_(Ciliated)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DNAH12 DZIP3 DNAH6 HYDIN

1.06e-04182604975f6275777fc578eba528e50f69891c66ec44ad
ToppCellCiliated_cells-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

DNAH12 DZIP3 DNAH6 HYDIN

1.06e-04182604e93968f800bfeb258e4e834fc8bf92d1cb72cd73
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH12 TEX26 DNAH6 HYDIN

1.10e-04184604797b6a6d6f6aafae98f75ca8bffe8263f8d3ff9b
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH12 TEX26 DNAH6 HYDIN

1.10e-0418460477d5b60a20b277f589b18f7a131142a7ef2dac17
ToppCellCiliated_cells-B-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

DNAH12 TEX26 DNAH6 HYDIN

1.13e-041856044fc7113d3dadc716ec5a8e62b58543cc00ce5b16
ToppCellCiliated_cells-B-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

DNAH12 DZIP3 DNAH6 HYDIN

1.13e-04185604f012c243343e1d1956db19b34d062e9b13de2b2a
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH12 DZIP3 DNAH6 HYDIN

1.15e-0418660476033438426d8f9c72cd6691a7baf92104c9f03d
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH12 TEX26 DNAH6 HYDIN

1.15e-0418660485787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCellCiliated_cells-B-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

DNAH12 DZIP3 DNAH6 HYDIN

1.17e-041876046fa38dbccca36bc7a4fef46de74c6688f599f421
ToppCell(7)_Epithelial_cells-(7)_Epithelial-F_(Ciliated)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

DNAH12 DZIP3 DNAH6 HYDIN

1.20e-041886045ba5cbb403518026e9040379fb5d99339ea977d8
ToppCell21-Trachea-Epithelial-Multiciliated_cell|Trachea / Age, Tissue, Lineage and Cell class

DNAH12 TEX26 DNAH6 HYDIN

1.20e-04188604803bf76a85b3033d2a04b08dd2c03ce9c15529ba
ToppCell343B-Epithelial_cells-Epithelial-F_(Ciliated)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DNAH12 DZIP3 DNAH6 HYDIN

1.22e-0418960457ab947b81dbd9d3e896be89e28c4a62cf720837
ToppCell343B-Epithelial_cells-Epithelial-F_(Ciliated)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DNAH12 DZIP3 DNAH6 HYDIN

1.22e-04189604ebc16b8eab84167d74446783d7e802acedc6b9c6
ToppCellcellseq2-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH12 TEX26 DNAH6 HYDIN

1.22e-04189604a3cd4c2da4feb9bdcd8957f3e344d095da1367b8
ToppCellMulticiliated|World / shred by cell class for nasal brushing

DNAH12 TEX26 DNAH6 HYDIN

1.22e-0418960434b110aef839376228c5a403a6b5047a945f472b
ToppCellcellseq2-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH12 TEX26 DNAH6 HYDIN

1.22e-0418960493b1026bb1ba759e5704561c9a5de14a30c08894
ToppCellEpithelial_cells-Ciliated_cells-B|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

DNAH12 DZIP3 DNAH6 HYDIN

1.25e-04190604426a4806f6e39d4d57c6746609d30bb3ca62df7d
ToppCellNasal_Brush-Epithelial-Ciliated_2|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

DNAH12 TEX26 DNAH6 HYDIN

1.25e-041906049ce7df056bfb24d70db4c3c4a2c57d89115de877
ToppCell343B-Epithelial_cells-Epithelial-F_(Ciliated)|343B / Donor, Lineage, Cell class and subclass (all cells)

DNAH12 TEX26 DNAH6 HYDIN

1.25e-04190604169e600e95878000acf5d11f813f9028c7249646
ToppCell343B-Epithelial_cells-Epithelial-F_(Ciliated)-|343B / Donor, Lineage, Cell class and subclass (all cells)

DNAH12 TEX26 DNAH6 HYDIN

1.25e-041906040cc36117c793d83cf4a1f66f47758a07d6712bd3
ToppCellNasal_Brush-Epithelial-Ciliated_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

DNAH12 TEX26 DNAH6 HYDIN

1.25e-04190604833481ace2800354712e2ce709d5cdfd0aed3d42
ToppCellcellseq2-Epithelial-Epithelial_Airway|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH12 TEX26 DNAH6 HYDIN

1.25e-0419060417829f4de31b3d9e4d71ba4817d18842aa699773
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 NQO1 DNAH6 FOXG1

1.25e-041906042fdc024d3d673a0134b74b4c5a63afe924995730
ToppCellBAL-Control-Epithelial-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH12 TEX26 DNAH6 HYDIN

1.27e-04191604df8a1a6e78aa0cb941b94cb676bd6891d79f3687
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH12 TEX26 DNAH6 HYDIN

1.27e-041916047b5da29109aa28768c67653a1bc0f385c2d2269b
ToppCellASK428-Epithelial-Ciliated|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

DNAH12 NQO1 DZIP3 HYDIN

1.27e-041916040c4b926a28bc94f3cf4d68a911c0a189f6ff505e
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 TEX26 NQO1 DZIP3

1.27e-041916043cffaa64b9e2410daa8ec1f91cf03e49b89b51e7
ToppCellBAL-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH12 TEX26 DNAH6 HYDIN

1.27e-041916049f19098f260d5542aa8ba7eb6f91b44d0db6e0a4
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH12 TEX26 DNAH6 HYDIN

1.27e-04191604fa9f8b50bfc7911c858bc2f9dcd204873d97ac61
ToppCellControl-Epithelial|Control / Disease group,lineage and cell class (2021.01.30)

DNAH12 TEX26 DNAH6 HYDIN

1.27e-04191604b78547dae8328244a47c83346447bdd787efbcae
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DNAH12 TEX26 DNAH6 HYDIN

1.27e-04191604b4e335e798c9617356b8e24412f9270c42dce656
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH12 TEX26 DNAH6 HYDIN

1.27e-04191604c4b223b33c020a064f576711a3d700eb60a2d737
ToppCellBAL-Control-Epithelial-Epithelial|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH12 TEX26 DNAH6 HYDIN

1.27e-04191604c50d6a1a6209ed4157f7c00fc24d4ecb43790f44
ToppCellBAL-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH12 TEX26 DNAH6 HYDIN

1.27e-041916045129f778a9283bfac4ff322c21c5ca71da4b7174
ToppCellControl-Epithelial-Ciliated|Control / Disease group,lineage and cell class (2021.01.30)

DNAH12 TEX26 DNAH6 HYDIN

1.27e-04191604cdc08e95a0c8f5c7a8d01b6bbaafdb54ef2f0d12
ToppCell10x5'-Liver-Myeloid_Mac-Macrophage|Liver / Manually curated celltypes from each tissue

TLR5 NQO1 EEF1AKMT1 NEDD4

1.27e-04191604bd7fd445e3d6316d0336c109889e7e6dc394a55e
ToppCellmoderate-Epithelial-Ciliated-diff|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH12 TEX26 NQO1 DZIP3

1.27e-04191604b1bb27aab6ec651b45d5eea0a6b61a1da0fc6204
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DNAH12 B3GALT9 NQO1 DZIP3

1.30e-04192604dcf2d0c2e8868104c4dba410456207f0d947029a
ToppCellmulticiliated|World / shred by cell class for turbinate

DNAH12 TEX26 DNAH6 HYDIN

1.30e-041926040f89ea0deb651ca11531c51ee94e0233608d22ea
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

DNAH12 DZIP3 DNAH6 HYDIN

1.30e-04192604be592e661367affced9ebe80849b466e6adb3a34
ToppCell15-Trachea-Epithelial-Intermediate_ciliated|Trachea / Age, Tissue, Lineage and Cell class

DNAH12 TEX26 HYDIN B4GALT5

1.30e-041926049cbe961a800c981cdc742a47ed18e9c8eb6430bd
ToppCellASK428-Epithelial-Ciliated|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

DNAH12 NQO1 DZIP3 HYDIN

1.30e-04192604356ebddd03aec341b79890977edb8ff0804999a1
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DNAH12 B3GALT9 NQO1 DZIP3

1.30e-04192604a22952b885c8a7704a4a9602fa03e4f2c786bf75
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

DNAH12 DZIP3 DNAH6 HYDIN

1.33e-041936040b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCellBronchial_Brush|World / Tissue, Lineage and Cell class of Lung Cells from 10X

DNAH12 DZIP3 DNAH6 HYDIN

1.33e-041936043e693ac4c92576e3f2c9efdd3f1d96d3d336e260
ToppCellControl-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DNAH12 DZIP3 DNAH6 HYDIN

1.33e-041936040e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH12 NEDD4L DNAH6 HYDIN

1.33e-04193604bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCellASK440-Epithelial-Ciliated|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

DNAH12 DZIP3 DNAH6 HYDIN

1.33e-04193604a0baa8be6f590b2031fede22be588715ae458e93
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DNAH12 DZIP3 DNAH6 HYDIN

1.33e-04193604ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellwk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

DNAH12 TEX26 DNAH6 HYDIN

1.35e-04194604756082a0f5953b52229bb60d40b84701cb6cb23d
DiseaseX-linked spondyloepiphyseal dysplasia tarda (implicated_via_orthology)

TRAPPC2B TRAPPC2

3.67e-062572DOID:0080362 (implicated_via_orthology)
DiseaseLiddle syndrome (implicated_via_orthology)

NEDD4L NEDD4

2.19e-054572DOID:0050477 (implicated_via_orthology)
Diseasespondyloepiphyseal dysplasia congenita (implicated_via_orthology)

TRAPPC2B TRAPPC2

5.47e-056572DOID:14789 (implicated_via_orthology)
DiseasePR segment

SCN10A EEF1AKMT1

1.63e-0410572EFO_0005095
Diseaseurate measurement

USP34 PTPDC1 ACSM3 NT5C2 FGF4 HERC4 B4GALT5

1.63e-03895577EFO_0004531
DiseaseBladder Neoplasm

GGH PSMB2 NQO1

2.54e-03140573C0005695
DiseaseMalignant neoplasm of urinary bladder

GGH PSMB2 NQO1

2.59e-03141573C0005684
Diseaseschizophrenia, type 2 diabetes mellitus

NT5C2 UBE2Z

3.15e-0343572MONDO_0005090, MONDO_0005148
DiseaseParoxysmal atrial fibrillation

USP34 SCN10A ZPBP2

3.44e-03156573C0235480
Diseasefamilial atrial fibrillation

USP34 SCN10A ZPBP2

3.44e-03156573C3468561
DiseasePersistent atrial fibrillation

USP34 SCN10A ZPBP2

3.44e-03156573C2585653
DiseaseAtrial Fibrillation

USP34 SCN10A ZPBP2

3.69e-03160573C0004238
Diseasemultiple sclerosis (is_marker_for)

B4GALT6 B4GALT5

4.07e-0349572DOID:2377 (is_marker_for)
DiseaseL2 Acute Lymphoblastic Leukemia

NQO1 NT5C2

4.23e-0350572C0023453

Protein segments in the cluster

PeptideGeneStartEntry
KGFAVMALAYYNYED

ACOT1

181

Q86TX2
EHYDPKEYDPFYMSK

FAM228B

126

P0C875
FDMDYTLAVYKSPEY

NT5C2

51

P49902
KYMYLLPYTEFFGGV

B4GALT5

261

O43286
YYFAGFQDDSLIYMD

ATG4C

331

Q96DT6
AYDFYKPDMLSEYPI

HMGCS1

201

Q01581
FCMEYEKYPDEYKGY

CHM

301

P24386
YDGEMDYKTYLDFVL

PPP2R3C

321

Q969Q6
SKEMFNPYYGLFEYS

NEDD4

1016

P46934
EAAYDPYAYPSDYDM

EIF3L

11

Q9Y262
LMKAIDFEYYGYLDE

ISY1

151

Q9ULR0
GNIDLMYFPYYGKKF

ATP1B2

221

P14415
YETYELVEKFYDPMF

FOLH1

556

Q04609
YDTDPFLFYVMTEYD

KAT5

331

Q92993
MEGYYTFHFLYFKDK

FBXO3

376

Q9UK99
GIYEFIMKNFPYYRE

FOXG1

206

P55316
YNAYESYKYPGMFIA

FGF4

166

P08620
LDPKYGMFRYYEDSR

HERC4

766

Q5GLZ8
YELVEKFYDPMFKYH

FOLH1B

251

Q9HBA9
CPFDEKGLVYDYMYE

DNAH12

1821

Q6ZR08
KRFAMYGEEFIFYDY

EEF1AKMT1

106

Q8WVE0
YPEMYILKGGYKEFF

CDC25B

516

P30305
YDYSYPFLDETIMKS

FMO6P

331

O60774
DYFEEYFAMNYSLPK

ENPEP

331

Q07075
TYLPEAFMEAGIYFY

PTPDC1

141

A2A3K4
MVYDYYEKDGEAFLL

OVOS2

1416

Q6IE36
DEMPIFKLDYNYFYH

DZIP3

381

Q86Y13
FIGEFAYTYAAMYDK

NQO1

121

P15559
AYTYAAMYDKGPFRS

NQO1

126

P15559
TELYFEKGEYFVEMY

ACP3

316

P15309
FDMDYTLAAYKSPAY

NT5DC4

21

Q86YG4
YKYSESGIYFAPMAD

DNAH6

3781

Q9C0G6
FKKYVMSTETYYFGP

HYDIN

2816

Q4G0P3
ILDFGDMSYGYYVFE

HYKK

251

A2RU49
YMYILPYKEFFGGVS

B4GALT6

256

Q9UBX8
EFISTMEGYKYPVYG

GGH

226

Q92820
FGAKGLSYDFYEVFM

ADA2

446

Q9NZK5
DLKDMLGFAPSRYYY

SLC6A15

556

Q9H2J7
YYMDYLAALAKAPFA

PSMB2

116

P49721
IFYDLKDPFDAAGYY

SH3TC1

1246

Q8TE82
YYDMYEPEGVKIFRC

SLC26A3

526

P40879
YLNMDKVPGFYQFFY

URB1

1761

O60287
KYYPDYCSGEAFIMS

B3GALT9

236

A8MXE2
LYFEKFPGYYDTMDA

ACSS3

526

Q9H6R3
FPGYYDTMDAGYMDE

ACSS3

531

Q9H6R3
FYITGDRGYMDKDGY

ACSM3

456

Q53FZ2
GAIPIDFYYFMAKIF

TMEM68

131

Q96MH6
EMVFKIIAFDPYYYF

SCN10A

711

Q9Y5Y9
SAFYLSYFDMLYPED

SPDEF

56

O95238
FFMEQYKYERYSPSS

SLCO1C1

131

Q9NYB5
YMYFKAEPYAADEGS

USP47

1031

Q96K76
MEKSFLEYYDFYEVA

UBE2Z

271

Q9H832
DVYDLYIKFSMNPFY

TRAPPC2

101

P0DI81
YQSDYDKTYPDFLML

TEX26

236

Q8N6G2
EYFAFLYEFAKMGEE

USP34

2441

Q70CQ2
TEPDMYKYDAYLCFS

TLR5

686

O60602
DVYDLYIKFSMNPFY

TRAPPC2B

101

P0DI82
FSPYFYMLYLTAESK

PIGM

271

Q9H3S5
MFPAGIYDTKYAAEF

TOE1

221

Q96GM8
DFMVFAYREPDYSYQ

ZPBP2

131

Q6X784
YSMQFGGYAKEADYV

HEBP1

131

Q9NRV9
LSKEMFNPYYGLFEY

NEDD4L

671

Q96PU5