Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alkaline phosphatase activity	ALPL ALPP ALPG	7.50e-07	6	68	3	GO:0004035
GeneOntologyCellularComponent	side of membrane	SELP IL12RB1 CRLF1 HLA-DQA2 FCRLA TECTA ITGA9 RYR1 ALPL ALPP ALPG TFRC	3.05e-05	875	70	12	GO:0098552
GeneOntologyCellularComponent	external side of plasma membrane	SELP IL12RB1 CRLF1 HLA-DQA2 FCRLA ITGA9 ALPP ALPG TFRC	5.66e-05	519	70	9	GO:0009897
GeneOntologyCellularComponent	lysosomal lumen	LGMN HSPG2 MAN2B2 TPP1	3.29e-04	98	70	4	GO:0043202
Domain	Alk_phosphatase	ALPL ALPP ALPG	1.84e-07	4	68	3	PF00245
Domain	Alkaline_phosphatase_AS	ALPL ALPP ALPG	1.84e-07	4	68	3	IPR018299
Domain	Alkaline_phosphatase	ALPL ALPP ALPG	1.84e-07	4	68	3	IPR001952
Domain	alkPPc	ALPL ALPP ALPG	1.84e-07	4	68	3	SM00098
Domain	ALKALINE_PHOSPHATASE	ALPL ALPP ALPG	1.84e-07	4	68	3	PS00123
Domain	DnaJ_C	DNAJB1 DNAJB4 DNAJB5	3.82e-06	9	68	3	IPR002939
Domain	DnaJ_C	DNAJB1 DNAJB4 DNAJB5	3.82e-06	9	68	3	PF01556
Domain	HSP40/DnaJ_pept-bd	DNAJB1 DNAJB4 DNAJB5	3.82e-06	9	68	3	IPR008971
Domain	TIL	FCGBP TECTA MUC6	9.92e-06	12	68	3	PF01826
Domain	C8	FCGBP TECTA MUC6	9.92e-06	12	68	3	PF08742
Domain	Unchr_dom_Cys-rich	FCGBP TECTA MUC6	1.29e-05	13	68	3	IPR014853
Domain	C8	FCGBP TECTA MUC6	1.29e-05	13	68	3	SM00832
Domain	TIL_dom	FCGBP TECTA MUC6	1.63e-05	14	68	3	IPR002919
Domain	EGF	SELP HSPG2 CELSR1 FCGBP FAT3 TECTA TNR	2.31e-05	235	68	7	SM00181
Domain	VWD	FCGBP TECTA MUC6	2.50e-05	16	68	3	SM00216
Domain	VWF_type-D	FCGBP TECTA MUC6	2.50e-05	16	68	3	IPR001846
Domain	VWFD	FCGBP TECTA MUC6	2.50e-05	16	68	3	PS51233
Domain	VWD	FCGBP TECTA MUC6	2.50e-05	16	68	3	PF00094
Domain	EGF-like_dom	SELP HSPG2 CELSR1 FCGBP FAT3 TECTA TNR	3.34e-05	249	68	7	IPR000742
Domain	TILa	FCGBP TECTA	3.91e-05	3	68	2	PF12714
Domain	TILa_dom	FCGBP TECTA	3.91e-05	3	68	2	IPR025615
Domain	VWC_out	FCGBP TECTA MUC6	4.29e-05	19	68	3	SM00215
Domain	Myotonic_dystrophy_kinase_coil	CDC42BPG CDC42BPA	7.80e-05	4	68	2	IPR014930
Domain	Myotonic_dystrophy_kinase_coil	CDC42BPG CDC42BPA	7.80e-05	4	68	2	PD011252
Domain	DMPK_coil	CDC42BPG CDC42BPA	7.80e-05	4	68	2	PF08826
Domain	DnaJ_domain_CS	DNAJB1 DNAJB4 DNAJB5	1.27e-04	27	68	3	IPR018253
Domain	Alkaline_phosphatase_core	ALPL ALPP ALPG	1.93e-04	31	68	3	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ALPL ALPP ALPG	1.93e-04	31	68	3	IPR017849
Domain	-	ALPL ALPP ALPG	1.93e-04	31	68	3	3.40.720.10
Domain	PbH1	SHCBP1 PKHD1L1	1.94e-04	6	68	2	SM00710
Domain	PbH1	SHCBP1 PKHD1L1	1.94e-04	6	68	2	IPR006626
Domain	LAM_G_DOMAIN	HSPG2 CELSR1 FAT3	3.55e-04	38	68	3	PS50025
Domain	Pectin_lyase_fold/virulence	SHCBP1 PKHD1L1	3.61e-04	8	68	2	IPR011050
Domain	Laminin_G_2	HSPG2 CELSR1 FAT3	4.14e-04	40	68	3	PF02210
Domain	VWF_dom	FCGBP TECTA MUC6	4.79e-04	42	68	3	IPR001007
Domain	LamG	HSPG2 CELSR1 FAT3	5.49e-04	44	68	3	SM00282
Domain	GAIN_dom_N	CELSR1 ADGRB2	7.03e-04	11	68	2	IPR032471
Domain	GAIN	CELSR1 ADGRB2	7.03e-04	11	68	2	PF16489
Domain	DnaJ	DNAJB1 DNAJB4 DNAJB5	7.10e-04	48	68	3	PF00226
Domain	DNAJ_1	DNAJB1 DNAJB4 DNAJB5	7.54e-04	49	68	3	PS00636
Domain	DNAJ_2	DNAJB1 DNAJB4 DNAJB5	7.54e-04	49	68	3	PS50076
Domain	DnaJ	DNAJB1 DNAJB4 DNAJB5	7.54e-04	49	68	3	SM00271
Domain	-	DNAJB1 DNAJB4 DNAJB5	7.54e-04	49	68	3	1.10.287.110
Domain	DnaJ_domain	DNAJB1 DNAJB4 DNAJB5	8.48e-04	51	68	3	IPR001623
Domain	EGF	SELP HSPG2 CELSR1 TECTA	1.15e-03	126	68	4	PF00008
Domain	CNH	CDC42BPG CDC42BPA	1.16e-03	14	68	2	SM00036
Domain	ConA-like_dom	HSPG2 CELSR1 FAT3 TRIM17 RYR1	1.21e-03	219	68	5	IPR013320
Domain	Laminin_G	HSPG2 CELSR1 FAT3	1.23e-03	58	68	3	IPR001791
Domain	CNH	CDC42BPG CDC42BPA	1.33e-03	15	68	2	PF00780
Domain	CNH	CDC42BPG CDC42BPA	1.33e-03	15	68	2	PS50219
Domain	CNH_dom	CDC42BPG CDC42BPA	1.33e-03	15	68	2	IPR001180
Domain	EGF_3	SELP HSPG2 CELSR1 FAT3 TNR	1.65e-03	235	68	5	PS50026
Domain	EGF_1	SELP HSPG2 CELSR1 FAT3 TNR	2.36e-03	255	68	5	PS00022
Domain	CRIB	CDC42BPG CDC42BPA	2.38e-03	20	68	2	PS50108
Domain	EGF-like_CS	SELP HSPG2 CELSR1 FAT3 TNR	2.61e-03	261	68	5	IPR013032
Domain	CRIB_dom	CDC42BPG CDC42BPA	2.62e-03	21	68	2	IPR000095
Domain	-	IL12RB1 HSPG2 CRLF1 HLA-DQA2 FCRLA KIR2DL4 TNR PKHD1L1	2.73e-03	663	68	8	2.60.40.10
Domain	EGF_2	SELP HSPG2 CELSR1 FAT3 TNR	2.79e-03	265	68	5	PS01186
Domain	HormR	CELSR1 ADGRB2	3.71e-03	25	68	2	SM00008
Pathway	KEGG_FOLATE_BIOSYNTHESIS	ALPL ALPP ALPG	8.11e-06	11	53	3	M2220
Pubmed	Structural evidence of functional divergence in human alkaline phosphatases.	ALPL ALPP ALPG	2.99e-08	4	69	3	12372831
Pubmed	Stage-specific expression patterns of alkaline phosphatase during development of the first arch skeleton in inbred C57BL/6 mouse embryos.	ALPL ALPP ALPG	2.99e-08	4	69	3	9061447
Pubmed	Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.	ALPL ALPP ALPG	2.99e-08	4	69	3	9056646
Pubmed	Central role of pyrophosphate in acellular cementum formation.	ALPL ALPP ALPG	7.45e-08	5	69	3	22675556
Pubmed	Two alkaline phosphatase genes are expressed during early development in the mouse embryo.	ALPL ALPP ALPG	7.45e-08	5	69	3	2133555
Pubmed	Germ cell nuclear antigen (GCNA1) expression does not require a gonadal environment or steroidogenic factor 1: examination of GCNA1 in ectopic germ cells and in Ftz-F1 null mice.	ALPL ALPP ALPG	7.45e-08	5	69	3	9291464
Pubmed	Dissection of the odontoblast differentiation process in vitro by a combination of FGF1, FGF2, and TGFbeta1.	ALPL ALPP ALPG	1.49e-07	6	69	3	10878613
Pubmed	Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters.	APC ALPP ALPG	2.60e-07	7	69	3	26831517
Pubmed	TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors.	ALPL ALPP ALPG	1.62e-06	12	69	3	31289197
Pubmed	General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions.	APC ALPP ALPG	2.68e-06	14	69	3	36639541
Pubmed	Malignant hyperthermia, environmental heat stress, and intracellular calcium dysregulation in a mouse model expressing the p.G2435R variant of RYR1.	RYR1 ALPL	3.88e-06	2	69	2	30236258
Pubmed	Hsc40, a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 in mammalian cells.	DNAJB1 DNAJB5	3.88e-06	2	69	2	10570961
Pubmed	Mutation of a single amino acid converts germ cell alkaline phosphatase to placental alkaline phosphatase.	ALPP ALPG	3.88e-06	2	69	2	1939159
Pubmed	Purification and partial sequencing of human placental alkaline phosphatase.	ALPP ALPG	3.88e-06	2	69	2	6651840
Pubmed	Modifications in a flexible surface loop modulate the isozyme-specific properties of mammalian alkaline phosphatases.	ALPL ALPP	3.88e-06	2	69	2	8244974
Pubmed	Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.	ALPP ALPG	3.88e-06	2	69	2	11124260
Pubmed	Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids.	ALPP ALPG	3.88e-06	2	69	2	3461452
Pubmed	Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning.	ALPL ALPG	3.88e-06	2	69	2	9823315
Pubmed	Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells.	ALPP ALPG	3.88e-06	2	69	2	3459156
Pubmed	Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein.	ALPP ALPG	3.88e-06	2	69	2	1730777
Pubmed	Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase.	ALPP ALPG	3.88e-06	2	69	2	2153284
Pubmed	Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA.	ALPP ALPG	3.88e-06	2	69	2	3001717
Pubmed	Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse.	RYR1 ALPL	3.88e-06	2	69	2	17122579
Pubmed	Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage.	RYR1 ALPL	3.88e-06	2	69	2	22131268
Pubmed	Mammalian alkaline phosphatase catalysis requires active site structure stabilization via the N-terminal amino acid microenvironment.	ALPL ALPP	3.88e-06	2	69	2	16893177
Pubmed	Molecular cloning and sequence analysis of human placental alkaline phosphatase.	ALPP ALPG	3.88e-06	2	69	2	3512548
Pubmed	P-Selectin-Mediated Adhesion between Platelets and Tumor Cells Promotes Intestinal Tumorigenesis in Apc(Min/+) Mice.	SELP APC	3.88e-06	2	69	2	25999791
Pubmed	Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution.	ALPP ALPG	3.88e-06	2	69	2	3042787
Pubmed	Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme.	ALPP ALPG	3.88e-06	2	69	2	3422741
Pubmed	Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification.	FAT3 GATA2 TECTA	9.69e-06	21	69	3	32492250
Pubmed	Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature.	DNAJB1 DNAJB4 DNAJB5	1.12e-05	22	69	3	11147971
Pubmed	The defect seen in the phosphatidylinositol hydrolysis pathway in HIV-infected lymphocytes and lymphoblastoid cells is due to inhibition of the inositol 1,4,5-trisphosphate 1,3,4,5-tetrakisphosphate 5-phosphomonoesterase.	ALPL ALPP	1.16e-05	3	69	2	1321014
Pubmed	Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases.	ALPP ALPG	1.16e-05	3	69	2	3443302
Pubmed	Assignment of the perlecan (heparan sulfate proteoglycan) gene to mouse chromosome 4.	HSPG2 ALPL	1.16e-05	3	69	2	1686572
Pubmed	Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.	ALPP ALPG	1.16e-05	3	69	2	19407215
Pubmed	Plakophilin3 loss leads to increased adenoma formation and rectal prolapse in APCmin mice.	PKP3 APC	1.16e-05	3	69	2	34823217
Pubmed	Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes.	ALPP ALPG	1.16e-05	3	69	2	2286375
Pubmed	Intestinal Alkaline Phosphatase Regulates Tight Junction Protein Levels.	ALPP ALPG	1.16e-05	3	69	2	27106638
Pubmed	Organic pyrophosphates as substrates for human alkaline phosphatases.	ALPP ALPG	1.16e-05	3	69	2	16742561
Pubmed	Effects of disruption of the embryonic alkaline phosphatase gene on preimplantation development of the mouse.	ALPP ALPG	1.16e-05	3	69	2	10767088
Pubmed	Function assignment to conserved residues in mammalian alkaline phosphatases.	ALPP ALPG	1.16e-05	3	69	2	11937510
Pubmed	Genetic Factors Involved in Mandibular Prognathism.	HSPG2 ALPL	1.16e-05	3	69	2	28570402
Pubmed	MUSEAP, a novel reporter gene for the study of long-term gene expression in immunocompetent mice.	ALPP ALPG	1.16e-05	3	69	2	11722850
Pubmed	A novel phosphatase upregulated in Akp3 knockout mice.	ALPP ALPG	1.16e-05	3	69	2	17901166
Pubmed	The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.	DNAJB1 DNAJB4 DNAJB5	1.29e-05	23	69	3	21231916
Pubmed	Interactions between CD36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet.	ALPP ALPG	2.32e-05	4	69	2	21900644
Pubmed	Novel Role of the ALPI Gene Associated with Constipation Caused by Complement Component 3 Deficiency.	ALPP ALPG	2.32e-05	4	69	2	39273477
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	CYP2D6 ATXN7 GDPD3 SEZ6L2 SNX19 RCN3	3.15e-05	303	69	6	25056061
Pubmed	Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding.	CDC42BPG CDC42BPA	5.79e-05	6	69	2	15194684
Pubmed	Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study.	NPAS3 TNR	5.79e-05	6	69	2	18521090
Pubmed	Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia.	NPAS3 TNR	5.79e-05	6	69	2	19573479
Pubmed	Hydrolysis and absorption of pantothenate and its coenzymes in the rat small intestine.	ALPP ALPG	5.79e-05	6	69	2	6619987
Pubmed	Quantitative genetics of age-related retinal degeneration: a second F1 intercross between the A/J and C57BL/6 strains.	GATA2 APLF	5.79e-05	6	69	2	17277741
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	HSPG2 SLC38A4 RCC1 SEZ6L2 RYR1	6.87e-05	214	69	5	22199357
Pubmed	MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.	CDC42BPG CDC42BPA	8.09e-05	7	69	2	29162624
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	DNAJB1 CNOT11 POC1A SHCBP1 APC DNAJB4 XPC ALPP ALPG TFRC	9.01e-05	1155	69	10	20360068
Pubmed	Population study of genetic polymorphisms and superficial bladder cancer risk in Han-Chinese smokers in Shanghai.	CYP2D6 XPC	1.38e-04	9	69	2	19350405
Pubmed	In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells.	IL12RB1 APC	1.38e-04	9	69	2	18504307
Pubmed	Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.	CELSR1 ITGA9	1.38e-04	9	69	2	28705793
Pubmed	A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation.	ALPP ALPG	1.38e-04	9	69	2	21324897
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PLEKHH1 HIVEP3 CDC42BPG MAN2B2 CDC42BPA COQ8A ATXN7 PKP3 ANKRD17 RAPGEF2 TECTA	1.59e-04	1489	69	11	28611215
Pubmed	Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis.	ALPP ALPG	1.73e-04	10	69	2	37709732
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	DNAJB1 HSPG2 FCGBP CDC42BPA GDPD3 TPP1 TECTA RYR1 ALPL	1.76e-04	1016	69	9	19056867
Pubmed	Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.	DNAJB1 DNAJB4	2.11e-04	11	69	2	24318877
Pubmed	IFN-λ derived from nonsusceptible enterocytes acts on tuft cells to limit persistent norovirus.	ALPP ALPG	2.11e-04	11	69	2	37703370
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	LGMN HSPG2 MAN2B2 TPP1 ALPL ALPP TFRC	2.14e-04	613	69	7	22268729
Pubmed	GATA-1 self-association controls erythroid development in vivo.	GATA2 TFRC	2.53e-04	12	69	2	17374603
Pubmed	A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis.	ALPP ALPG	2.53e-04	12	69	2	27802136
Pubmed	CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1.	LGMN HSPG2 TFRC	2.86e-04	64	69	3	36369321
Pubmed	VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance.	GATA2 ITGA9	2.98e-04	13	69	2	31461654
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CDC42BPG TMEM62 COQ8A TPP1 SHCBP1 APC ANKRD17	3.05e-04	650	69	7	38777146
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	HSPG2 PKP3 ANKRD17 ALPL TFRC	3.21e-04	298	69	5	30737378
Pubmed	Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.	CELSR1 FAT3 TFRC	3.27e-04	67	69	3	21875946
Pubmed	Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.	CELSR1 TPP1 ATP8A2	4.04e-04	72	69	3	25917818
Pubmed	Hdac3 regulates lymphovenous and lymphatic valve formation.	GATA2 ITGA9	4.57e-04	16	69	2	29035278
Pubmed	Tracing the origin of adult intestinal stem cells.	ALPP ALPG	4.57e-04	16	69	2	31092921
Pubmed	Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.	GATA2 ITGA9	4.57e-04	16	69	2	26542011
Pubmed	A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).	SELP IL12RB1 HSPG2 TNR	5.22e-04	186	69	4	20673868
Pubmed	Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.	SELP IL12RB1 HSPG2 TNR	5.22e-04	186	69	4	20452482
Pubmed	GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126.	GATA2 ITGA9	5.81e-04	18	69	2	31582413
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	LGMN HSPG2 CELSR1 MAN2B2 CRLF1 DNAJB4 SEZ6L2 RCN3 TFRC	5.97e-04	1201	69	9	35696571
Pubmed	HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.	ALPP ALPG	6.49e-04	19	69	2	31345929
Pubmed	Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.	ALPP ALPG	7.20e-04	20	69	2	26023099
Pubmed	Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates.	ALPP ALPG	7.20e-04	20	69	2	19531352
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ATXN7 PKP3 SHCBP1 ANKRD17 RCC1 XPC MN1	8.58e-04	774	69	7	15302935
Pubmed	The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.	GDPD3 PKP3	8.73e-04	22	69	2	16949565
Pubmed	Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.	GATA2 TFRC	8.73e-04	22	69	2	26166573
Pubmed	Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice.	ALPP ALPG	9.55e-04	23	69	2	24680895
Pubmed	Continued expression of GATA3 is necessary for cochlear neurosensory development.	GATA2 TECTA	1.04e-03	24	69	2	23614009
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	PKP3 SHCBP1 APC	1.11e-03	102	69	3	15778465
Pubmed	Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction.	DNAJB1 DNAJB4	1.13e-03	25	69	2	27483141
Pubmed	TFAM is required for maturation of the fetal and adult intestinal epithelium.	ALPP ALPG	1.22e-03	26	69	2	29684311
Pubmed	Retinoic acid deficiency impairs the vestibular function.	GATA2 TECTA	1.22e-03	26	69	2	23536097
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	LGMN HSPG2 FCGBP MAN2B2 GDPD3 TPP1 PABPC3 ALPL	1.24e-03	1070	69	8	23533145
Pubmed	Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.	HSPG2 ITGA9	1.32e-03	27	69	2	31541017
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	CNOT11 ATG2B APC ANKRD17	1.39e-03	242	69	4	34011540
Pubmed	Genome-wide association study of hematological and biochemical traits in a Japanese population.	RCN3 ALPL TFRC	1.61e-03	116	69	3	20139978
Pubmed	Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1.	ALPP ALPG	1.63e-03	30	69	2	26057579
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	PABPC3 ADGRB2 APC RAPGEF2 TNR	1.66e-03	430	69	5	32581705
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	PLEKHH1 COQ8A ATXN7 ANKRD17 XPC RYR1	1.68e-03	638	69	6	31182584
Interaction	C2CD4B interactions	CNOT11 CELSR1 FAT3 APC	1.54e-05	44	69	4	int:C2CD4B
Interaction	KHDC1 interactions	POC1A DNAJB4 DNAJB5	2.08e-05	16	69	3	int:KHDC1
Interaction	NLRP8 interactions	DNAJB4 DNAJB5	3.46e-05	3	69	2	int:NLRP8
Cytoband	2q37	ALPP ALPG	1.04e-03	31	70	2	2q37
Cytoband	11p15	TPP1 PKP3	1.99e-03	43	70	2	11p15
GeneFamily	Alkaline phosphatases	ALPL ALPP ALPG	1.01e-07	4	54	3	1072
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJB1 DNAJB4 DNAJB5	4.21e-04	49	54	3	584
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	SELP HSPG2 GATA2 SCD5 TECTA ITGA9 PKHD1L1 ALPL	7.76e-10	194	70	8	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	SELP HSPG2 GATA2 TECTA ITGA9 PKHD1L1 ALPL	1.84e-08	187	70	7	7876dcb4800c2e54874df3d933efb79307a64a97
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 CELSR1 SLC38A4 ATP8A2 NPAS3 PKHD1L1	5.49e-07	190	70	6	f50b9814a1beac67dc042a8c27dfd085ceeda3a6
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 CELSR1 SLC38A4 ATP8A2 NPAS3 PKHD1L1	5.49e-07	190	70	6	a22a510b4a257eb0eaf09c7ae7978d3d2f07a58c
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 CELSR1 SLC38A4 ATP8A2 NPAS3 PKHD1L1	5.49e-07	190	70	6	57c136bf6d7feafb4a220877bed0cc8fdf314db2
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELP LGMN CELSR1 ATP8A2 GATA2 PKHD1L1	6.58e-07	196	70	6	7d5eaed189aa6116f3799be010139fb675ec65e0
ToppCell	Biopsy_Other_PF-Epithelial-KRT5-/KRT17+\|Biopsy_Other_PF / Sample group, Lineage and Cell type	CDC42BPG CELSR1 CRLF1 PKP3 SCD5 SEZ6L2	7.41e-07	200	70	6	077e6b9340686de9d0f11b035a8954e1f6a1b790
ToppCell	facs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELP LGMN CELSR1 SLC38A4 PKHD1L1	6.61e-06	167	70	5	a4a795751644b22af616335379e64ae95175180c
ToppCell	mild-Others-CD34+_GATA2+_cells\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	HSPG2 GATA2 ITGA9 SEZ6L2 MN1	7.63e-06	172	70	5	379f6f271e653d5e404851e51a189bd582bb0f43
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SELP HSPG2 NPAS3 ITGA9 PKHD1L1	8.76e-06	177	70	5	d68132e145bd413404fdbe215b5dbe520e756e50
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL12RB1 CNOT11 POC1A SHCBP1 RCC1	1.00e-05	182	70	5	0370b395ceb9d4d66f80cf60dd8c28ac60af5c7b
ToppCell	droplet-Lung-nan-21m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 SLC38A4 ATP8A2 NPAS3 PKHD1L1	1.09e-05	185	70	5	3a4ae836e882e8d29eb0a2dfab5677f10f2d365f
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D175\|Adult / Lineage, Cell type, age group and donor	LGMN NPAS3 ITGA9 RYR1 RCN3	1.09e-05	185	70	5	ab5704b96f1d368911308797d10c7c52766ab134
ToppCell	droplet-Lung-nan-21m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 SLC38A4 ATP8A2 NPAS3 PKHD1L1	1.09e-05	185	70	5	224f0b022c21dd40bf1f7503f00b3107ef958975
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FAT3 ADGRB2 NPAS3 TECTA TNR	1.11e-05	186	70	5	bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell-B_cell\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CELSR1 PABPC3 FCRLA TNR APLF	1.17e-05	188	70	5	99fdd305f75ed38dd507e7a17ffe27c26b86e454
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CELSR1 PABPC3 FCRLA TNR APLF	1.17e-05	188	70	5	5a0519b189e96001d95f9d24363448e8602b8d4d
ToppCell	3'_v3-Lung-Myeloid_Dendritic-Cycling_Dendritic\|Lung / Manually curated celltypes from each tissue	POC1A HLA-DQA2 SHCBP1 SLC12A8 ALPL	1.17e-05	188	70	5	0e8ac42c439f30a05e015210e1d5c2dcb9d9d471
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell-B_cell-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CELSR1 PABPC3 FCRLA TNR APLF	1.17e-05	188	70	5	e8b7c1c2eb2e390ad79b358236468b0f15ea58a5
ToppCell	COVID-19-Heart-EC_(POSTN)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SELP HSPG2 SCD5 ITGA9 PKHD1L1	1.20e-05	189	70	5	7346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCell	10x5'v1-week_14-16-Myeloid_macrophage-stroma-erythroid_macrophage\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	LGMN FCGBP FAT3 RCN3 ALPL	1.23e-05	190	70	5	cf463b2f227f3cc7d3fd296c810c0cbe51cbee72
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CELSR1 ATP8A2 NPAS3 ITGA9 PKHD1L1	1.23e-05	190	70	5	a1514d2186eb4fe569971ab22dc0c17d353fb94a
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CELSR1 ATP8A2 NPAS3 ITGA9 PKHD1L1	1.23e-05	190	70	5	0bb954a94317cfc742b9b6221bb80f8baa6d3ff1
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CELSR1 ATP8A2 NPAS3 ITGA9 PKHD1L1	1.23e-05	190	70	5	26e2237f65cb43723c5da853831b40df2982d6e4
ToppCell	facs-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 ATP8A2 NPAS3 ITGA9 PKHD1L1	1.27e-05	191	70	5	48823a97c38263f2c6e58348214f5b62773a6368
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 ATP8A2 NPAS3 ITGA9 PKHD1L1	1.27e-05	191	70	5	0eedc66e967b1837ce2c14f8c14b3c1eba868c76
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	SELP HSPG2 SCD5 ITGA9 PKHD1L1	1.30e-05	192	70	5	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A4 PKP3 SHCBP1 GATA2 MUC6	1.30e-05	192	70	5	d5ec4cdb15620a5abfc83577353501186c2bc86a
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	SELP HSPG2 SCD5 ITGA9 PKHD1L1	1.33e-05	193	70	5	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-airway_progenitor_early\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	DNAJB1 CELSR1 CRLF1 PKP3 ALPL	1.33e-05	193	70	5	de569c6e507856fd3ac2311f246cb597074ed30c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A4 PKP3 SHCBP1 GATA2 MUC6	1.33e-05	193	70	5	5da60321bcf761913eb30779b6d8b1e933c5e51e
ToppCell	severe-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SELP CELSR1 APC FCRLA PKHD1L1	1.36e-05	194	70	5	2fee6083fb56b16d1f04fd0b92ec622fd26ba3fa
ToppCell	severe-B_cell\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CELSR1 HLA-DQA2 APC FCRLA PKHD1L1	1.40e-05	195	70	5	0fc3c605609c9e6bdea15d73c45def2188ae5fb1
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SELP HSPG2 HLA-DQA2 SHCBP1 PKHD1L1	1.43e-05	196	70	5	eb8c9a4a5eb21d43ff7b25deae5896c236f669b9
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELP LGMN CELSR1 ATP8A2 PKHD1L1	1.43e-05	196	70	5	dbf154b3d166ffd07be717dac8d8a3350ac63e16
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SELP HSPG2 POC1A SHCBP1 PKHD1L1	1.47e-05	197	70	5	76b61e60a757e58b465569538e632d6d9953e89a
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SCNN1D SLC12A8 XPC FCRLA TNR	1.47e-05	197	70	5	b8dc192fc98428bbb701cc2ea57fc8ad93397785
ToppCell	Influenza-Influenza_Severe-Lymphocyte-B-B_intermediate\|Influenza_Severe / Disease, condition lineage and cell class	LGMN HLA-DQA2 SLC12A8 FCRLA PKHD1L1	1.51e-05	198	70	5	ab622fee61714471af3a7be0af356e8a484dcaff
ToppCell	severe_influenza-B_cell\|severe_influenza / disease group, cell group and cell class (v2)	ATXN7 HLA-DQA2 GDPD3 FCRLA	4.96e-05	128	70	4	92b250186d6bb08ce4f2f5cc4fb93928f6b92d3a
ToppCell	AT2_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	CDC42BPG HSPG2 CRLF1 SCD5	5.42e-05	131	70	4	ff4e618bd944f852bbd34438f740187aca82460f
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHH1 HOXD1 ADGRB2 SEZ6L2	5.59e-05	132	70	4	3661665ed5b257f51530122cb9a9c849b5baa1fb
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SELP CRLF1 NPAS3 TECTA	8.04e-05	145	70	4	78f5f4b96420c7f391e4d32a9ed151ed95fad90b
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC38A4 PKP3 SHCBP1 MUC6	8.04e-05	145	70	4	bfa196ac1db7acbfcbb2ba9f137036a95e16e091
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC38A4 SLC12A8 MUC6 SNX19	1.15e-04	159	70	4	4000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC38A4 SLC12A8 MUC6 SNX19	1.15e-04	159	70	4	7619d0d49738dd08daf01b42664691a5323aa793
ToppCell	wk_15-18-Hematologic-Meg-ery-Platelet\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SELP GATA2 PKHD1L1 APLF	1.18e-04	160	70	4	768f3cefc3ad4cda229e598cce8bde574cf64bb2
ToppCell	lymphoid-T_cell-pro-T_cell\|T_cell / Lineage, cell class and subclass	HLA-DQA2 GATA2 PKHD1L1 ALPG	1.18e-04	160	70	4	66fe86d2f37983761141e5bb3de127f0b4bb0951
ToppCell	BL-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	GATA2 ADGRB2 ITGA9 APLF	1.23e-04	162	70	4	25ec9df914445b4daae4fd28fd0e60b64797c46d
ToppCell	droplet-Marrow-nan-21m-Hematologic-erythroid_progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL12RB1 CELSR1 RYR1 RCN3	1.23e-04	162	70	4	d0ffebf5adee8a3ac9b81a4b793184f54010489a
ToppCell	droplet-Heart-nan-18m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKP3 SHCBP1 FCRLA RYR1	1.23e-04	162	70	4	7f425a3983325a5a3ea33f812b15aa010cc55de0
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_mature_unknown_2\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PLEKHH1 FAT3 MINDY4 ALPL	1.26e-04	163	70	4	e393e5ff885a42b2b44e430d3d5a58f5e50eb732
ToppCell	IIF-Other-HSPC\|IIF / Disease, Lineage and Cell Type	GATA2 ITGA9 SEZ6L2 MN1	1.26e-04	163	70	4	1e0d38fbed38ac48478868a1480172a1a3f7c1b7
ToppCell	390C-Fibroblasts-Fibroblast-F\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SELP POC1A KIR2DL4 SCD5	1.29e-04	164	70	4	2957065d7f1332c5280d47be7cc342286f84be3e
ToppCell	390C-Fibroblasts-Fibroblast-F-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SELP POC1A KIR2DL4 SCD5	1.29e-04	164	70	4	82e57d618c6e59bca4a03d31caf35b6043dfcf52
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.4\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HIVEP3 CRLF1 MINDY4 ALPP	1.32e-04	165	70	4	4d364e1aae41aea483d1311e5e8ef4fc33e30d5e
ToppCell	facs-Heart-RA-24m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKP3 FCRLA RYR1 ALPG	1.32e-04	165	70	4	36415924d05373e9dd3665be599f4f3f40bf0497
ToppCell	facs-Heart-RA-24m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKP3 FCRLA RYR1 ALPG	1.32e-04	165	70	4	56310fddd3d8e4afdfde066d26cee9747e5b8c6a
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC38A4 SLC12A8 MUC6 SNX19	1.36e-04	166	70	4	bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAN2B2 SHCBP1 ITGA9 TNR	1.36e-04	166	70	4	43f84d3cd58e93ce00c241656c4cba27604b4932
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SELP HSPG2 NPAS3 DNAJB5	1.36e-04	166	70	4	9d4b44eb56ad38c26aed73444edf389abca6bdf6
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC38A4 SLC12A8 MUC6 SNX19	1.36e-04	166	70	4	5e3b998d740b24f790fad37350d704ca0ea10b77
ToppCell	facs-Heart-RA-24m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKP3 FCRLA RYR1 ALPG	1.45e-04	169	70	4	dcf92121fb00e3b6498e2648363e90ac044ea396
ToppCell	3'_v3-Lung-Myeloid_Mac-Intestinal_macrophages\|Lung / Manually curated celltypes from each tissue	LGMN FCGBP HLA-DQA2 ITGA9	1.45e-04	169	70	4	241644823e6f949aaf4c671d4579721d7ef6b0e5
ToppCell	droplet-Lung-30m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IL12RB1 CNOT11 ADGRB2 RCC1	1.45e-04	169	70	4	822e5b6c1e55e196e6d2a38bf183fd220c45703e
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAJB1 HSPG2 ALPP ALPG	1.45e-04	169	70	4	cd16e8462ee09877be962fbd9a3badcb825820b0
ToppCell	NS-critical-LOC-Epithelial-FOXN4+\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	POC1A ADGRB2 MINDY4 SEZ6L2	1.49e-04	170	70	4	f6a0162bb690dbc19ff1cec64cb933744ad3b496
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GATA2 SCNN1D ITGA9 RYR1	1.49e-04	170	70	4	be2a34c70665d8d11332b1a70eda03d77cb7f7dd
ToppCell	URO-Lymphocyte-B-B_intermediate\|URO / Disease, Lineage and Cell Type	CELSR1 HLA-DQA2 FCRLA PKHD1L1	1.49e-04	170	70	4	e11d1510518cedabeece96d4adbb90999e6326fa
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-ABC_aged-B_naive\|bone_marrow / Manually curated celltypes from each tissue	FCGBP HLA-DQA2 FCRLA RYR1	1.52e-04	171	70	4	fcc31a9a69f96de10d1324a5a4fbfe4289bf4984
ToppCell	Influenza_Severe-B_intermediate\|World / Disease group and Cell class	LGMN HLA-DQA2 SLC12A8 FCRLA	1.52e-04	171	70	4	4d33e1dc1efc423dbdd5f4cca6d6440a68add8d0
ToppCell	droplet-Heart-HEART-1m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 ATP8A2 NPAS3 PKHD1L1	1.59e-04	173	70	4	9dc7746a84f0e268a7c061e1bbcd5e31903034dc
ToppCell	droplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	POC1A SHCBP1 ADGRB2 SCD5	1.59e-04	173	70	4	c399786aa25bdbe3394988db6955842b5b7e6b41
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRLF1 SLC38A4 FCRLA ITGA9	1.59e-04	173	70	4	e944ea3a0a368f856efacbda4600605cf751dd9c
ToppCell	368C-Myeloid-Mast_cell\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	GATA2 ADGRB2 DNAJB4 ITGA9	1.59e-04	173	70	4	8cffb4a37d30b6626188309b868ac4a62e91262f
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRLF1 SLC38A4 FCRLA ITGA9	1.59e-04	173	70	4	85fa5918e9c1f6bb4757e3350cfc71ee75c55640
ToppCell	368C-Myeloid-Mast_cell-\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	GATA2 ADGRB2 DNAJB4 ITGA9	1.59e-04	173	70	4	fb87ea74bf70aa83b458edf728c81857c8b8eb96
ToppCell	Influenza_Severe-B_intermediate\|Influenza_Severe / Disease group and Cell class	LGMN HLA-DQA2 SLC12A8 FCRLA	1.62e-04	174	70	4	4276bdaac53aebd3084323a90ecde572d3177446
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXD1 RCC1 FCRLA ALPL	1.62e-04	174	70	4	021ebc6ec022b992d7b25333ba0b7416371e041b
ToppCell	3'-GW_trimst-1-LargeIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXD1 ETHE1 PKP3 UGT2B10	1.62e-04	174	70	4	ca067e8ec55bbc3deafc09f08bc13af08364d165
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXD1 RCC1 FCRLA ALPL	1.62e-04	174	70	4	c2fc78dd6c440737ded59676961e4c7b923084ce
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 SLC38A4 ATP8A2 PKHD1L1	1.66e-04	175	70	4	f6e1d7297a4dbb38e1ab4f738d91f0e62abaee69
ToppCell	metastatic_Brain-Endothelial_cells-Lymphatic_ECs\|Endothelial_cells / Location, Cell class and cell subclass	CELSR1 SLC38A4 PKP3 SEZ6L2	1.70e-04	176	70	4	42541dfe20eb29625d47c0bb79bf3c21a2460340
ToppCell	COPD-Epithelial-Aberrant_Basaloid\|COPD / Disease state, Lineage and Cell class	CELSR1 CRLF1 PKP3 SCD5	1.70e-04	176	70	4	11d867bcb4f2471b4e13a5f7dc1c24286197f26d
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LGMN FCGBP ITGA9 TFRC	1.73e-04	177	70	4	382f0d6bbff01e84b0c7840e74ac865864e6da89
ToppCell	P28-Endothelial-lymphatic_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CELSR1 ATP8A2 ITGA9 PKHD1L1	1.73e-04	177	70	4	6e330aa3c87fd640526b746a9deb3b2250d2518c
ToppCell	P28-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CELSR1 ATP8A2 ITGA9 PKHD1L1	1.73e-04	177	70	4	e96a7e4544710aaab8bd2800ecff9667880a8bf4
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HSPG2 CELSR1 SCD5 ITGA9	1.73e-04	177	70	4	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKP3 FAT3 GATA2 RCN3	1.73e-04	177	70	4	c1f838e425ebb04482829b1957e3c1347127e6de
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRB2 MN1 RCN3 ALPL	1.77e-04	178	70	4	27497dbfcf9bb4dd0bf7caa0bd78c7e85f5c18ee
ToppCell	3'_v3-Lung-Myeloid_Mac-Erythrophagocytic_macrophages\|Lung / Manually curated celltypes from each tissue	LGMN HLA-DQA2 ITGA9 MN1	1.77e-04	178	70	4	b63cee443cc1b7416112bf610d7c9d41e4fa37ed
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LGMN RYR1 RCN3 TFRC	1.77e-04	178	70	4	24e8c62060455159235985f456af0c5023a7f3f5
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRB2 MN1 RCN3 ALPL	1.77e-04	178	70	4	d348a9550db940d204706529759dc51e30506b5f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LGMN RYR1 RCN3 TFRC	1.77e-04	178	70	4	4f1cc954d4d9b5b2b75a4cf995ba81e2ada27084
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	POC1A GDPD3 SHCBP1 DNAJB5	1.77e-04	178	70	4	c7e890cd02206c516cf1d7692ea7abc8ce746482
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRLF1 FAT3 SLC12A8 ITGA9	1.77e-04	178	70	4	ccea3c8908d72f5fecd151a133048c8e9758304c
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CELSR1 GATA2 ITGA9 PKHD1L1	1.77e-04	178	70	4	4b3ea0921bc598ebb9f63780ecdf8ad4349f3666
ToppCell	10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-early_osteoblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FAT3 TRIM17 RCN3 ALPL	1.77e-04	178	70	4	e32f5ed7a492edfa7073416008b1fcfae6b854ad
ToppCell	COVID-19_Mild-Hematopoietic_SC-HSPC\|COVID-19_Mild / Disease group, lineage and cell class	HSPG2 CDC42BPA GATA2 ITGA9	1.81e-04	179	70	4	19fcf48f5e02e4cb2b328efb4502f337e1282f72
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HSPG2 CDC42BPA GATA2 ITGA9	1.81e-04	179	70	4	4bb2debfc9e9f258cd38e797ef160bd440aad6af
ToppCell	droplet-Lung-nan-18m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL12RB1 HOXD1 PKP3 TECTA	1.81e-04	179	70	4	8ebd0c7ac99ac8194fa1a2aac88a893739a97725
Drug	BIAP	ALPL ALPP ALPG	4.13e-06	11	68	3	CID005487027
Drug	AttoPhos	ALPL ALPP ALPG	4.13e-06	11	68	3	CID000188920
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A	HIVEP3 DNAJB1 TPP1 DNAJB4 DNAJB5 ITGA9	1.69e-05	181	68	6	5578_UP
Drug	lead nitrate	ATP8A2 ITGA9 ALPL ALPP	1.77e-05	52	68	4	CID000024924
Drug	17-DMAG; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA	DNAJB1 TPP1 DNAJB4 RAPGEF2 DNAJB5 RYR1	2.29e-05	191	68	6	993_UP
Drug	Indomethacin [53-86-1]; Down 200; 11.2uM; PC3; HT_HG-U133A	ATXN7 TPP1 PKP3 GATA2 DNAJB4 SCD5	2.50e-05	194	68	6	5049_DN
Drug	15d-PGJ2; Down 200; 10uM; PC3; HT_HG-U133A	IL12RB1 CDC42BPA HOXD1 ADGRB2 RCC1 DNAJB5	2.50e-05	194	68	6	4455_DN
Drug	Tiabendazole [148-79-8]; Down 200; 19.8uM; MCF7; HT_HG-U133A	IL12RB1 TMEM62 HOXD1 RCC1 DNAJB5 SCD5	2.57e-05	195	68	6	4402_DN
Drug	5-hydroxycytidine	ALPL ALPP	2.63e-05	3	68	2	CID000198207
Drug	Alphostatin	ALPL ALPP	2.63e-05	3	68	2	CID000174788
Drug	Ethamsylate [2624-44-4]; Up 200; 15.2uM; HL60; HT_HG-U133A	IL12RB1 CDC42BPA HOXD1 PKP3 SLC12A8 TECTA	2.65e-05	196	68	6	2915_UP
Drug	alpha-estradiol; Up 200; 0.01uM; HL60; HT_HG-U133A	CRLF1 PKP3 DNAJB5 TECTA MN1 MUC6	2.65e-05	196	68	6	2670_UP
Drug	genistein; Down 200; 10uM; MCF7; HT_HG-U133A	CRLF1 ATXN7 PKP3 GATA2 SLC12A8 RCN3	2.72e-05	197	68	6	5595_DN
Drug	Meclofenamic acid sodium salt monohydrate [6385-02-0]; Up 200; 11.8uM; MCF7; HT_HG-U133A	ATP8A2 APC DNAJB5 SCD5 MN1 ALPG	2.72e-05	197	68	6	2291_UP
Drug	Sulfachloropyridazine [80-32-0]; Down 200; 14uM; PC3; HT_HG-U133A	HOXD1 ATXN7 ADGRB2 APC RCC1 DNAJB5	2.72e-05	197	68	6	3769_DN
Drug	lead phosphate	ATP8A2 ALPL ALPP	2.80e-05	20	68	3	CID000024009
Drug	Enalapril maleate [76095-16-4]; Up 200; 8.2uM; HL60; HT_HG-U133A	CDC42BPA TPP1 NPAS3 APC SLC12A8 TECTA	2.80e-05	198	68	6	2397_UP
Drug	S(+)-Terguride [37686-84-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A	HIVEP3 IL12RB1 CDC42BPA HOXD1 RCC1 RAPGEF2	2.80e-05	198	68	6	6459_DN
Drug	Methimazole [60-56-0]; Down 200; 35uM; HL60; HT_HG-U133A	HIVEP3 IL12RB1 CDC42BPA APC SLC12A8 RCN3	2.80e-05	198	68	6	2570_DN
Drug	2-propylpentanoic acid; Up 200; 50uM; PC3; HT_HG-U133A	HOXD1 GDPD3 PKP3 APC RAPGEF2 MN1	2.80e-05	198	68	6	1222_UP
Drug	3-indoxyl phosphate	ALPL ALPP	5.25e-05	4	68	2	CID000026292
Drug	ammediol	ALPL ALPP	5.25e-05	4	68	2	CID000001531
Drug	p-bromotetramisole	ALPL ALPP	5.25e-05	4	68	2	CID000005121
Drug	ethylethanolamine	ALPL ALPP	5.25e-05	4	68	2	CID000008072
Drug	flecainide	CYP2D6 GDPD3 SCNN1D RYR1	6.08e-05	71	68	4	CID000003355
Drug	SMR 6	ALPL ALPP	8.74e-05	5	68	2	CID006439864
Drug	ranelic acid	ALPL ALPP	8.74e-05	5	68	2	CID003052774
Drug	Fast Blue RR	ALPL ALPP	8.74e-05	5	68	2	CID000093116
Drug	mitomycin phosphate	ALPL ALPP	8.74e-05	5	68	2	CID000130219
Drug	Smoke	DNAJB1 CELSR1 GDPD3 ATP8A2 PKP3 XPC RYR1 ALPL ALPP ALPG TFRC	9.67e-05	937	68	11	ctd:D012906
Drug	5-fluorosalicylic acid	ALPL ALPP	1.31e-04	6	68	2	CID000067658
Drug	FADP	ALPL ALPP	1.31e-04	6	68	2	CID003081481
Drug	hexamethylphosphoramide	ADGRB2 ALPL ALPP	1.70e-04	36	68	3	CID000012679
Drug	Phenoxybenzamine hydrochloride [63-92-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A	DNAJB1 HSPG2 TPP1 DNAJB4 XPC	1.74e-04	174	68	5	5613_UP
Drug	p-aminodiphenylamine	ALPL ALPP	1.83e-04	7	68	2	CID000007564
Drug	norfluoxetine	CYP2D6 ALPP	1.83e-04	7	68	2	ctd:C036139
Drug	1-octen-3-one	RYR1 ALPL	1.83e-04	7	68	2	CID000061346
Drug	naphthol-AS-BI	MAN2B2 ALPL ALPP	1.84e-04	37	68	3	CID000071060
Drug	4-nitrophenol	CYP2D6 UGT2B10 ALPL ALPP ALPG	1.88e-04	177	68	5	CID000000980
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A_EA	COQ8A TPP1 ETHE1 ATG2B DNAJB4	2.04e-04	180	68	5	1065_UP
Drug	tetramisole	APC ALPL ALPP ALPG	2.05e-04	97	68	4	CID000003913
Drug	SCH 23390	DNAJB1 DNAJB4 DNAJB5 TECTA MN1 RYR1	2.08e-04	285	68	6	ctd:C534628
Drug	Etoposide [33419-42-0]; Up 200; 6.8uM; MCF7; HT_HG-U133A	COQ8A TPP1 APC XPC DNAJB5	2.20e-04	183	68	5	5027_UP
Drug	17-AAG; Up 200; 1uM; HL60; HT_HG-U133A	DNAJB1 CRLF1 DNAJB4 MUC6 ALPP	2.25e-04	184	68	5	2686_UP
Drug	ferric chloride hexahydrate	SELP ALPL TFRC	2.33e-04	40	68	3	CID000024810
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A	HIVEP3 DNAJB1 DNAJB4 DNAJB5 RYR1	2.37e-04	186	68	5	5566_UP
Drug	Loperamide hydrochloride [34552-83-5]; Up 200; 7.8uM; MCF7; HT_HG-U133A	HIVEP3 HSPG2 ADGRB2 SLC12A8 RYR1	2.37e-04	186	68	5	1533_UP
Drug	fosfosal	ALPL ALPP	2.43e-04	8	68	2	CID000003418
Drug	orellanine	ALPL ALPP	2.43e-04	8	68	2	CID000089579
Drug	iopentol	ALPL ALPP	2.43e-04	8	68	2	CID000056016
Drug	(1S,2E,3S)-2-[(2E)-2-[(7aR)-7a-methyl-1-[(E,1R,4R)-1,4,5-trimethylhex-2-enyl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-3-methyl-cyclohexanol	ALPL ALPP	2.43e-04	8	68	2	CID011953890
Drug	BCIP	ALPL ALPP ALPG	2.50e-04	41	68	3	CID000065409
Drug	carbamazepine; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA	DNAJB1 CDC42BPA CRLF1 TPP1 RCC1	2.55e-04	189	68	5	835_UP
Drug	geldanamycin; Up 200; 1uM; MCF7; HG-U133A	HIVEP3 DNAJB1 SHCBP1 DNAJB4 RAPGEF2	2.55e-04	189	68	5	611_UP
Drug	Flumethasone [2135-17-3]; Down 200; 9.8uM; PC3; HT_HG-U133A	HIVEP3 HOXD1 PKP3 ADGRB2 APC	2.81e-04	193	68	5	3712_DN
Drug	Pivampicillin [33817-20-8]; Down 200; 8.6uM; PC3; HT_HG-U133A	SLF2 TPP1 SLC12A8 RCC1 RAPGEF2	2.81e-04	193	68	5	5046_DN
Drug	Estrone [53-16-7]; Down 200; 14.8uM; PC3; HT_HG-U133A	APC SLC12A8 RCC1 MN1 RCN3	2.88e-04	194	68	5	6647_DN
Drug	ST021200; Down 200; 10uM; PC3; HT_HG-U133A	ATG2B GATA2 ADGRB2 APC DNAJB4	2.95e-04	195	68	5	7493_DN
Drug	Acenocoumarol [152-72-7]; Up 200; 11.4uM; PC3; HT_HG-U133A	GDPD3 TPP1 ATP8A2 APC RCC1	2.95e-04	195	68	5	5878_UP
Drug	Glafenine hydrochloride [65513-72-6]; Down 200; 9.8uM; MCF7; HT_HG-U133A	TMEM62 CDC42BPA ATXN7 DNAJB4 SLC12A8	2.95e-04	195	68	5	7018_DN
Drug	Doxylamine succinate [562-10-7]; Down 200; 10.2uM; PC3; HT_HG-U133A	HIVEP3 HOXD1 PKP3 ADGRB2 RCN3	2.95e-04	195	68	5	4235_DN
Drug	Antipyrine [60-80-0]; Down 200; 21.2uM; PC3; HT_HG-U133A	IL12RB1 PKP3 ADGRB2 SLC12A8 RCN3	2.95e-04	195	68	5	4251_DN
Drug	ICI182,780; Up 200; 1uM; MCF7; HT_HG-U133A	HIVEP3 CDC42BPA HOXD1 TPP1 APC	3.02e-04	196	68	5	5926_UP
Drug	Aceclofenac [89796-99-6]; Up 200; 11.2uM; PC3; HT_HG-U133A	HIVEP3 GATA2 APC RCC1 RAPGEF2	3.02e-04	196	68	5	7269_UP
Drug	Canrenoic acid potassium salt [2181-04-6]; Down 200; 10uM; PC3; HT_HG-U133A	ATXN7 GATA2 DNAJB4 SLC12A8 RCC1	3.02e-04	196	68	5	2065_DN
Drug	Mimosine [500-44-7]; Down 200; 20.2uM; PC3; HT_HG-U133A	HIVEP3 HOXD1 PKP3 SLC12A8 DNAJB5	3.02e-04	196	68	5	6703_DN
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A	IL12RB1 HOXD1 COQ8A RCC1 DNAJB5	3.02e-04	196	68	5	5236_UP
Drug	Hydrochlorothiazide [58-93-5]; Up 200; 13.4uM; MCF7; HT_HG-U133A	HIVEP3 SLC12A8 RAPGEF2 DNAJB5 SCD5	3.02e-04	196	68	5	1487_UP
Drug	Metanephrine hydrochloride DL [881-95-8]; Up 200; 17.2uM; HL60; HG-U133A	HIVEP3 CDC42BPA ATXN7 RCC1 SNX19	3.02e-04	196	68	5	2015_UP
Drug	deferoxamine mesylate salt; Down 200; 100uM; MCF7; HG-U133A	HIVEP3 IL12RB1 CDC42BPA SLF2 RAPGEF2	3.02e-04	196	68	5	485_DN
Drug	Famprofazone [22881-35-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A	IL12RB1 CRLF1 PKP3 SNX19 RCN3	3.02e-04	196	68	5	6029_DN
Drug	Atractyloside potassium salt [102130-43-8]; Down 200; 5uM; HL60; HT_HG-U133A	HOXD1 TPP1 APC SLC12A8 RCN3	3.09e-04	197	68	5	2573_DN
Drug	Ampicillin trihydrate [7177-48-2]; Up 200; 10uM; MCF7; HT_HG-U133A	APC SLC12A8 DNAJB5 MN1 ALPG	3.09e-04	197	68	5	1530_UP
Drug	15(S)-15-methyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	HIVEP3 CDC42BPA TPP1 APC TNR	3.09e-04	197	68	5	7521_UP
Drug	Bethanechol chloride [590-63-6]; Down 200; 20.4uM; PC3; HT_HG-U133A	TPP1 PKP3 ADGRB2 APC DNAJB5	3.09e-04	197	68	5	5114_DN
Drug	Ethamivan [304-84-7]; Up 200; 18uM; PC3; HT_HG-U133A	HIVEP3 GATA2 DNAJB4 RCC1 DNAJB5	3.09e-04	197	68	5	7260_UP
Drug	Ketoconazole [65277-42-1]; Up 200; 7.6uM; MCF7; HT_HG-U133A	CELSR1 CDC42BPA TECTA MN1 ALPL	3.09e-04	197	68	5	5685_UP
Drug	(S)-(-)-Cycloserine [339-72-0]; Down 200; 39.2uM; MCF7; HT_HG-U133A	IL12RB1 CDC42BPA CRLF1 APC DNAJB5	3.09e-04	197	68	5	3870_DN
Drug	Norfloxacin [70458-96-7]; Up 200; 12.6uM; PC3; HT_HG-U133A	MAN2B2 PKP3 APC SLC12A8 DNAJB5	3.09e-04	197	68	5	7283_UP
Drug	Pentamidine isethionate [140-64-7]; Down 200; 6.8uM; PC3; HT_HG-U133A	HSPG2 TPP1 GATA2 RCC1 SCD5	3.09e-04	197	68	5	4573_DN
Drug	Ethisterone [434-03-7]; Up 200; 12.8uM; HL60; HT_HG-U133A	IL12RB1 HSPG2 SLC12A8 SEZ6L2 MUC6	3.09e-04	197	68	5	2366_UP
Drug	Bicuculline (+) [485-49-4]; Down 200; 10.8uM; MCF7; HT_HG-U133A	HSPG2 CDC42BPA SLC12A8 RAPGEF2 DNAJB5	3.09e-04	197	68	5	2796_DN
Drug	Lomefloxacin hydrochloride [98079-52-8]; Down 200; 10.4uM; MCF7; HT_HG-U133A	GATA2 APC RCC1 RAPGEF2 RCN3	3.09e-04	197	68	5	4745_DN
Drug	Prednisone [53-03-2]; Down 200; 11.2uM; PC3; HT_HG-U133A	HIVEP3 TPP1 ADGRB2 RCC1 DNAJB5	3.09e-04	197	68	5	4577_DN
Drug	Methoxamine hydrochloride [61-16-5]; Up 200; 16.2uM; HL60; HT_HG-U133A	PKP3 SLC12A8 ITGA9 MUC6 RYR1	3.09e-04	197	68	5	2488_UP
Drug	Idazoxan hydrochloride [79944-56-2]; Up 200; 16.6uM; PC3; HT_HG-U133A	HOXD1 ATP8A2 DNAJB5 SCD5 RYR1	3.09e-04	197	68	5	6747_UP
Drug	C75; Up 200; 10uM; MCF7; HT_HG-U133A	IL12RB1 ATXN7 ATP8A2 NPAS3 SCD5	3.09e-04	197	68	5	6423_UP
Drug	Aphos	ALPL ALPP	3.12e-04	9	68	2	CID000053051
Drug	naphthol AS-TR	ALPL ALPP	3.12e-04	9	68	2	CID000066718
Drug	aminohexane	ALPL ALPP	3.12e-04	9	68	2	CID000201427
Drug	phenolphthalein monophosphate	ALPL ALPP	3.12e-04	9	68	2	CID000128862
Drug	fosfluconazole	ALPL ALPP	3.12e-04	9	68	2	CID000214356
Drug	Novobiocin sodium salt [1476-53-5]; Down 200; 6.4uM; PC3; HT_HG-U133A	CDC42BPA TPP1 ADGRB2 SLC12A8 RCC1	3.16e-04	198	68	5	4569_DN
Drug	Pergolide mesylate [66104-23-2]; Down 200; 9.8uM; MCF7; HT_HG-U133A	CDC42BPA GATA2 DNAJB4 SLC12A8 RCC1	3.16e-04	198	68	5	7031_DN
Drug	Benzamil hydrochloride [2898-76-2]; Down 200; 11.2uM; PC3; HT_HG-U133A	HIVEP3 PKP3 ADGRB2 APC ALPP	3.16e-04	198	68	5	3738_DN
Drug	Betazole hydrochloride; Up 200; 27uM; MCF7; HT_HG-U133A	CRLF1 ADGRB2 SLC12A8 RCC1 DNAJB5	3.16e-04	198	68	5	1690_UP
Drug	Ketorolac tromethamine [74103-07-4]; Down 200; 10.6uM; MCF7; HT_HG-U133A	HIVEP3 HSPG2 APC RCC1 RAPGEF2	3.16e-04	198	68	5	6489_DN
Drug	Quinethazone [73-49-4]; Down 200; 13.8uM; MCF7; HT_HG-U133A	HIVEP3 CDC42BPA CRLF1 HOXD1 SNX19	3.16e-04	198	68	5	4351_DN
Drug	Aceclofenac [89796-99-6]; Down 200; 11.2uM; PC3; HT_HG-U133A	HSPG2 CELSR1 GDPD3 SLC12A8 RCC1	3.16e-04	198	68	5	2117_DN
Drug	Catechin-(+,-) hydrate [7295-85-4]; Down 200; 13.8uM; PC3; HT_HG-U133A	HIVEP3 CRLF1 HOXD1 TPP1 ADGRB2	3.24e-04	199	68	5	4255_DN
Disease	autosomal dominant limb-girdle muscular dystrophy type 1 (implicated_via_orthology)	DNAJB1 DNAJB4 DNAJB5	4.47e-08	4	67	3	DOID:0110305 (implicated_via_orthology)
Disease	congenital myopathy 21 (implicated_via_orthology)	DNAJB1 DNAJB4 DNAJB5	4.47e-08	4	67	3	DOID:0081353 (implicated_via_orthology)
Disease	Milroy Disease	CELSR1 GATA2	5.06e-05	5	67	2	C1704423
Disease	cerebral cavernous malformation (implicated_via_orthology)	CDC42BPG CDC42BPA	2.76e-04	11	67	2	DOID:0060669 (implicated_via_orthology)
Disease	myeloid leukemia (is_implicated_in)	GATA2 MN1	3.90e-04	13	67	2	DOID:8692 (is_implicated_in)
Disease	urolithiasis	MINDY4 ALPL ALPP	4.03e-04	63	67	3	MONDO_0024647
Disease	lysophosphatidylethanolamine 16:0 measurement	ANKRD17 TNR	1.59e-03	26	67	2	EFO_0010366
Disease	azoospermia (implicated_via_orthology)	CDC42BPG CDC42BPA	1.72e-03	27	67	2	DOID:14227 (implicated_via_orthology)
Disease	Oral ulcer	IL12RB1 CRLF1 HLA-DQA2	1.88e-03	107	67	3	HP_0000155
Disease	Early Pregnancy Loss	TNR ALPG TFRC	1.98e-03	109	67	3	C3830362
Disease	Miscarriage	TNR ALPG TFRC	1.98e-03	109	67	3	C4552766
Disease	Spontaneous abortion	TNR ALPG TFRC	1.98e-03	109	67	3	C0000786
Disease	Abortion, Tubal	TNR ALPG TFRC	1.98e-03	109	67	3	C0000822
Disease	caudate nucleus volume	FAT3 NPAS3	2.12e-03	30	67	2	EFO_0004830
Disease	pancreatic cancer (is_implicated_in)	APC XPC ITGA9	2.14e-03	112	67	3	DOID:1793 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RDGSFHYVHSTPFGN	TMEM62	166	Q0P6H9
HTEGYPSFLSVDHSG	ADGRB2	1391	O60241
GSSGSFHYTFHGDPH	DNAJB5	81	O75953
FHYTFHGDPHATFAS	DNAJB5	86	O75953
HGDPHATFASFFGGS	DNAJB5	91	O75953
VHFQHFSHPGDSDYG	APLF	391	Q8IW19
EHYSFGVEAVDHGSP	CELSR1	651	Q9NYQ6
SGTFHQHVPAGYMDF	ANKRD17	2511	O75179
NGTSFSYTFHGDPHA	DNAJB1	86	P25685
GPTYASFSHHFISDA	ATG2B	1466	Q96BY7
PHGYAFSQEEHGAVS	ATP8A2	1156	Q9NTI2
ATYGHYAPGEEFHDV	RCN3	141	Q96D15
FTFAISHEGHVYGFG	RCC1	251	P18754
FHDDGFLAFPGHVFS	HSPG2	4206	P98160
FSGHHLPFVGFTYTS	CDC42BPG	386	Q6DT37
GHFSTFDHHVYDFSG	MUC6	51	Q6W4X9
HGGFVTYVDFHPSGT	POC1A	186	Q8NBT0
SHGPSGQYTHEFDGD	HLA-DQA2	41	P01906
DDGGSHVHYATSAVF	HOXD1	126	Q9GZZ0
EVYFSPGHFAHGSDR	GDPD3	116	Q7L5L3
VSFAHLHFAGGYLPS	GPR151	16	Q8TDV0
YSGHHPQPASFCTFG	ATXN7	511	O15265
GSKGYGFVHFETHEA	PABPC3	136	Q9H361
HDGDTVSVHRPGFYA	PIPSL	371	A2A3N6
PATHGETYRCFGSFH	KIR2DL4	186	Q99706
VTADHSHVFSFGGYP	ALPP	376	P05187
DHSHVFSFGGYPLRG	ALPG	376	P10696
TADHSHVFTFGGYTP	ALPL	376	P05186
YLGYAVTAGHFSHPS	ITGA9	246	Q13797
AAHDYSSGLFHPGGF	GATA2	256	P23769
HGDPHATFAAFFGGS	DNAJB4	91	Q9UDY4
ASGDPHYTTFDGHRF	FCGBP	3656	Q9Y6R7
ADSGHYHCSGIFQSP	FCRLA	136	Q7L513
SHHGVFAFLVSPSPY	CYP2D6	476	P10635
TGPLGFHFTHSIYNA	FAT3	36	Q8TDW7
EGEFHFSVPHAAGAS	COQ8A	76	Q8NI60
IYPAHDYHGFTVSTV	ETHE1	191	O95571
TYHFGGNASAAGTPH	IL12RB1	436	P42701
PHSHLGTYGVFTNAA	SELP	811	P16109
ASSDAGPAGHFASVY	MAN2B2	466	Q9Y2E5
IPFGVAYHHSGLTSD	HELQ	636	Q8TDG4
TPGAHGETFLHTNYS	CRLF1	156	O75462
SFTHLDPEHGFIGYS	SLC12A8	201	A0AV02
TFHHPTYGSCYTVDG	SCNN1D	441	P51172
SDYFDTTPHGFETHT	RYR1	4966	P21817
GHVSPGTFFDKYSAA	MN1	951	Q10571
PAFFTFFTHHFGGHT	OR52N1	256	Q8NH53
AIGEGFHNYHHTFPF	SCD5	266	Q86SK9
GSSVFDYVHPGDHVE	NPAS3	191	Q8IXF0
FGFSGSHSYSPITVE	SEZ6L2	876	Q6UXD5
SQSSDYTGHVHPGTY	SLF2	651	Q8IX21
PGHYVVHGTFSIADS	SHCBP1	386	Q8NEM2
YADEHHPGTTSFGMS	SLC38A4	66	Q969I6
AFSGHHLPFVGFTYT	CDC42BPA	391	Q5VT25
SFFGHAHLGTGDPYT	TFRC	296	P02786
GSFAFDSPHHYTPIE	APC	1836	P25054
GGSTFEGLSTAFHHY	CNOT11	81	Q9UKZ1
SGHLPDVHGFNSYGS	PKP3	291	Q9Y446
TCVVFGEPHYHTFDG	TECTA	321	O75443
TLPFGHTHFDYSGDP	RAPGEF2	1271	Q9Y4G8
DFDVPTSHLIGAHGY	MINDY4	586	Q4G0A6
YIPHCSGHGNFSFES	TNR	171	Q92752
STPHHPFRGSYSFDD	HIVEP3	551	Q5T1R4
SYTHFAEKYHVPGTG	PKHD1L1	3231	Q86WI1
AFHHGFSPAIGVFGT	PKHD1L1	3341	Q86WI1
AREHSGTGFHPYTLY	SNX19	541	Q92543
VHFTNGTYHVVGFDG	PLEKHH1	1001	Q9ULM0
DGSHLHTYSQATFPG	TRIM17	436	Q9Y577
HSFSPGYSFERHSGG	UGT2B10	171	P36537
VQAITGFDFHGGYSH	XPC	791	Q01831
PGDCAGFAAHHAVSY	TMEM271	311	A0A286YF58
AEFHHYVGGPTETHV	TPP1	136	O14773
GPQDHVFIYFTDHGS	LGMN	136	Q99538