Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DENND2A TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I DENND11 TBC1D3G PLEKHG5 TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.41e-10	507	58	14	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DENND2A TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I DENND11 TBC1D3G PLEKHG5 TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.41e-10	507	58	14	GO:0030695
GeneOntologyMolecularFunction	GTPase activator activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	4.14e-10	279	58	11	GO:0005096
GeneOntologyMolecularFunction	enzyme regulator activity	CASP8AP2 DENND2A NCOR1 TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D EGFR TBC1D3I DENND11 TBC1D3G PLEKHG5 TBC1D3C TBC1D3B RCAN3 RCAN2 TBC1D3K TBC1D3F	8.68e-09	1418	58	19	GO:0030234
GeneOntologyMolecularFunction	enzyme activator activity	CASP8AP2 TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D EGFR TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	3.73e-08	656	58	13	GO:0008047
GeneOntologyMolecularFunction	molecular function activator activity	CASP8AP2 TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D EGFR SEMA3B TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	8.50e-06	1233	58	14	GO:0140677
GeneOntologyMolecularFunction	calcium-dependent protein serine/threonine phosphatase regulator activity	RCAN3 RCAN2	8.25e-05	5	58	2	GO:0008597
GeneOntologyMolecularFunction	sodium channel activity	TRPM2 CACNA1I GRIK4	4.65e-04	52	58	3	GO:0005272
GeneOntologyBiologicalProcess	activation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	8.06e-15	109	57	11	GO:0090630
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	5.79e-11	244	57	11	GO:0043547
GeneOntologyBiologicalProcess	positive regulation of hydrolase activity	CASP8AP2 TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D FGFR2 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	7.72e-10	499	57	13	GO:0051345
GeneOntologyBiologicalProcess	regulation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.67e-09	335	57	11	GO:0043087
GeneOntologyBiologicalProcess	positive regulation of catalytic activity	CASP8AP2 TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D EGFR FGFR2 TBC1D3I TOPORS TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	8.08e-08	1028	57	15	GO:0043085
GeneOntologyBiologicalProcess	regulation of hydrolase activity	CASP8AP2 TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D FGFR2 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	5.93e-07	878	57	13	GO:0051336
GeneOntologyBiologicalProcess	positive regulation of molecular function	ABRA CASP8AP2 TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D EGFR FGFR2 TBC1D3I TOPORS TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.00e-06	1430	57	16	GO:0044093
GeneOntologyBiologicalProcess	regulation of miRNA transcription	NCOR1 NCOR2 EGFR MYB	8.19e-05	83	57	4	GO:1902893
GeneOntologyBiologicalProcess	miRNA transcription	NCOR1 NCOR2 EGFR MYB	8.58e-05	84	57	4	GO:0061614
GeneOntologyBiologicalProcess	regulation of miRNA metabolic process	NCOR1 NCOR2 EGFR MYB	1.89e-04	103	57	4	GO:2000628
GeneOntologyBiologicalProcess	miRNA metabolic process	NCOR1 NCOR2 EGFR MYB	3.29e-04	119	57	4	GO:0010586
HumanPheno	Abnormality of the incisor	NECTIN1 HMGB3 CACNA1I FGFR2 VPS13B	1.42e-05	108	16	5	HP:0000676
HumanPheno	Abnormal incisor morphology	NECTIN1 CACNA1I FGFR2 VPS13B	3.25e-05	62	16	4	HP:0011063
HumanPheno	Recurrent mycobacterial infections	TYK2 SPAG1 IRF1 DNAH11	3.25e-05	62	16	4	HP:0011274
HumanPheno	Macrodontia	NECTIN1 CACNA1I VPS13B	1.08e-04	31	16	3	HP:0001572
MousePheno	abnormal heart ventricle size	TYK2 NCOR1 EGFR TRPM2 FGFR2 DNAH11	2.68e-05	228	37	6	MP:0031543
Domain	TBC	USP6 TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	2.05e-18	49	57	11	SM00164
Domain	RabGAP-TBC	USP6 TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	5.31e-18	53	57	11	PF00566
Domain	TBC_RABGAP	USP6 TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	8.29e-18	55	57	11	PS50086
Domain	Rab-GTPase-TBC_dom	USP6 TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	8.29e-18	55	57	11	IPR000195
Domain	N-CoR_GPS2_interact	NCOR1 NCOR2	9.15e-06	2	57	2	IPR031557
Domain	GPS2_interact	NCOR1 NCOR2	9.15e-06	2	57	2	PF15784
Domain	Calcipressin	RCAN3 RCAN2	2.74e-05	3	57	2	PF04847
Domain	Calcipressin	RCAN3 RCAN2	2.74e-05	3	57	2	IPR006931
Domain	Myb_DNA-binding	NCOR1 NCOR2 MYB	1.65e-04	35	57	3	PF00249
Domain	MYB_LIKE	NCOR1 NCOR2 MYB	2.11e-04	38	57	3	PS50090
Domain	SANT	NCOR1 NCOR2 MYB	4.77e-04	50	57	3	SM00717
Domain	SANT/Myb	NCOR1 NCOR2 MYB	5.36e-04	52	57	3	IPR001005
Domain	DUF1605	DHX15 YTHDC2	1.21e-03	17	57	2	IPR011709
Domain	OB_NTP_bind	DHX15 YTHDC2	1.21e-03	17	57	2	PF07717
Domain	HA2	DHX15 YTHDC2	1.36e-03	18	57	2	SM00847
Domain	HA2	DHX15 YTHDC2	1.36e-03	18	57	2	PF04408
Domain	Helicase-assoc_dom	DHX15 YTHDC2	1.36e-03	18	57	2	IPR007502
Domain	TyrKc	TYK2 EGFR FGFR2	2.46e-03	88	57	3	SM00219
Domain	Tyr_kinase_cat_dom	TYK2 EGFR FGFR2	2.46e-03	88	57	3	IPR020635
Domain	SANT_dom	NCOR1 NCOR2	2.84e-03	26	57	2	IPR017884
Domain	PROTEIN_KINASE_TYR	TYK2 EGFR FGFR2	3.24e-03	97	57	3	PS00109
Domain	Tyr_kinase_AS	TYK2 EGFR FGFR2	3.24e-03	97	57	3	IPR008266
Domain	SANT	NCOR1 NCOR2	3.29e-03	28	57	2	PS51293
Domain	PTPc	PTPRN PTPN21	5.39e-03	36	57	2	SM00194
Domain	DEAH_ATP_HELICASE	DHX15 YTHDC2	6.00e-03	38	57	2	PS00690
Domain	TYR_PHOSPHATASE_PTP	PTPRN PTPN21	6.31e-03	39	57	2	PS50055
Domain	PTPase_domain	PTPRN PTPN21	6.95e-03	41	57	2	IPR000242
Domain	Y_phosphatase	PTPRN PTPN21	6.95e-03	41	57	2	PF00102
Domain	Pkinase_Tyr	TYK2 EGFR FGFR2	7.18e-03	129	57	3	PF07714
Pathway	WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K	1.06e-11	99	42	9	M46448
Pathway	REACTOME_LOSS_OF_MECP2_BINDING_ABILITY_TO_THE_NCOR_SMRT_COMPLEX	NCOR1 NCOR2	1.80e-04	7	42	2	M27899
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	CASP8AP2 NCOR2 TOPORS	2.99e-04	44	42	3	M27295
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS	NCOR1 NCOR2	3.08e-04	9	42	2	M29809
Pathway	PID_HES_HEY_PATHWAY	NCOR1 NCOR2 MYB	3.87e-04	48	42	3	M288
Pathway	BIOCARTA_EGFR_SMRTE_PATHWAY	NCOR2 EGFR	4.69e-04	11	42	2	MM1432
Pathway	BIOCARTA_EGFR_SMRTE_PATHWAY	NCOR2 EGFR	4.69e-04	11	42	2	M18837
Pubmed	TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.01e-31	11	58	11	16863688
Pubmed	Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.	USP6 TBC1D3 TBC1D3D TBC1D3F	6.96e-12	4	58	4	8406013
Pubmed	The Tre2 (USP6) oncogene is a hominoid-specific gene.	USP6 TBC1D3 TBC1D3D TBC1D3C	3.48e-11	5	58	4	12604796
Pubmed	Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.	USP6 TBC1D3 TBC1D3D TBC1D3F	3.48e-11	5	58	4	8471161
Pubmed	DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.	TBC1D3E TBC1D3 TBC1D3H TBC1D3D TBC1D3G TBC1D3B TBC1D3F	4.07e-11	74	58	7	16625196
Pubmed	PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.	TBC1D3 TBC1D3D TBC1D3F	1.76e-08	4	58	3	12359748
Pubmed	PTPD1 supports receptor stability and mitogenic signaling in bladder cancer cells.	EGFR PTPN21	2.73e-06	2	58	2	20923765
Pubmed	CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.	NCOR1 NCOR2	2.73e-06	2	58	2	27733359
Pubmed	Loss of protocadherin-17 (PCDH-17) promotes metastasis and invasion through hyperactivation of EGFR/MEK/ERK signaling pathway in hepatocellular carcinoma.	EGFR PCDH17	2.73e-06	2	58	2	26386721
Pubmed	Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes.	NCOR1 NCOR2	2.73e-06	2	58	2	22944139
Pubmed	Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants.	NCOR1 NCOR2	2.73e-06	2	58	2	21131350
Pubmed	Promoter region of the murine fibroblast growth factor receptor 2 (bek/KGFR) gene.	EGFR FGFR2	2.73e-06	2	58	2	1408137
Pubmed	Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways.	NCOR1 NCOR2	2.73e-06	2	58	2	19299558
Pubmed	Unique forms of human and mouse nuclear receptor corepressor SMRT.	NCOR1 NCOR2	2.73e-06	2	58	2	10077563
Pubmed	Nuclear Receptor Corepressors NCOR1 and SMRT Regulate Metabolism via Intestinal Regulation of Carbohydrate Transport.	NCOR1 NCOR2	2.73e-06	2	58	2	39106294
Pubmed	Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals.	NCOR1 NCOR2	2.73e-06	2	58	2	31208445
Pubmed	NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.	NCOR1 NCOR2	2.73e-06	2	58	2	29531310
Pubmed	The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR.	EGFR RNF11	2.73e-06	2	58	2	27872256
Pubmed	Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma.	EGFR FGFR2	2.73e-06	2	58	2	24550739
Pubmed	Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling.	NCOR1 NCOR2	2.73e-06	2	58	2	26166430
Pubmed	Functional interactions with Pit-1 reorganize co-repressor complexes in the living cell nucleus.	NCOR1 NCOR2	8.19e-06	3	58	2	16030140
Pubmed	Involvement of SMRT corepressor in transcriptional repression by the vitamin D receptor.	NCOR1 NCOR2	8.19e-06	3	58	2	19098224
Pubmed	The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor.	NCOR1 NCOR2	8.19e-06	3	58	2	16373395
Pubmed	Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action.	NCOR1 NCOR2	8.19e-06	3	58	2	31404087
Pubmed	Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo.	NCOR1 NCOR2	8.19e-06	3	58	2	23292142
Pubmed	Diversity of human copy number variation and multicopy genes.	TBC1D3E TBC1D3G	8.19e-06	3	58	2	21030649
Pubmed	Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.	NCOR1 NCOR2	8.19e-06	3	58	2	24268577
Pubmed	Oligomerization of ETO is obligatory for corepressor interaction.	NCOR1 NCOR2	8.19e-06	3	58	2	11113190
Pubmed	Organic dust induces inflammatory gene expression in lung epithelial cells via ROS-dependent STAT-3 activation.	TYK2 EGFR	8.19e-06	3	58	2	31042082
Pubmed	Dynamic recruitment of protein tyrosine phosphatase PTPD1 to EGF stimulation sites potentiates EGFR activation.	EGFR PTPN21	8.19e-06	3	58	2	25062045
Pubmed	EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding.	NCOR1 NCOR2	8.19e-06	3	58	2	21518914
Pubmed	Co-regulation of B-Myb expression by E2F1 and EGF receptor.	EGFR MYB	8.19e-06	3	58	2	16299810
Pubmed	Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT.	NCOR1 NCOR2	8.19e-06	3	58	2	15802375
Pubmed	SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling.	NCOR1 NCOR2	8.19e-06	3	58	2	36238311
Pubmed	The murine DSCR1-like (Down syndrome candidate region 1) gene family: conserved synteny with the human orthologous genes.	RCAN3 RCAN2	8.19e-06	3	58	2	11080588
Pubmed	The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking.	TBC1D3 EGFR	8.19e-06	3	58	2	18319245
Pubmed	Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor.	NCOR1 NCOR2	8.19e-06	3	58	2	18852122
Pubmed	Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy.	EGFR FGFR2	8.19e-06	3	58	2	21173787
Pubmed	Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.	NCOR1 NCOR2	8.19e-06	3	58	2	22337871
Pubmed	Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors.	NCOR1 NCOR2	8.19e-06	3	58	2	15016838
Pubmed	PIAS1 interacts with FLASH and enhances its co-activation of c-Myb.	CASP8AP2 MYB	8.19e-06	3	58	2	21338522
Pubmed	FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci.	CASP8AP2 MYB	8.19e-06	3	58	2	18408764
Pubmed	A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2).	RCAN3 RCAN2	8.19e-06	3	58	2	10756093
Pubmed	Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis.	NCOR1 NCOR2	8.19e-06	3	58	2	34390859
Pubmed	RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding.	NCOR1 NCOR2	8.19e-06	3	58	2	12011091
Pubmed	Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.	RCAN3 RCAN2	8.19e-06	3	58	2	17595344
Pubmed	It's not just baby's babble/Babel: recent progress in understanding the language of early mammalian development: a minireview.	EGFR FGFR2	8.19e-06	3	58	2	9890755
Pubmed	The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD.	NCOR1 NCOR2	8.19e-06	3	58	2	10406466
Pubmed	Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.	NCOR1 NCOR2	8.19e-06	3	58	2	36316474
Pubmed	The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha.	NCOR1 NCOR2	8.19e-06	3	58	2	18052923
Pubmed	The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.	NCOR1 NCOR2	8.19e-06	3	58	2	11997503
Pubmed	Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation.	TYK2 EGFR FGFR2	9.86e-06	25	58	3	11294897
Pubmed	Silencing mediator for retinoid and thyroid hormone receptor and nuclear receptor corepressor attenuate transcriptional activation by the beta-catenin-TCF4 complex.	NCOR1 NCOR2	1.64e-05	4	58	2	18632669
Pubmed	A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones.	NCOR1 NCOR2	1.64e-05	4	58	2	19147680
Pubmed	NCoR1 and SMRT play unique roles in thyroid hormone action in vivo.	NCOR1 NCOR2	1.64e-05	4	58	2	25421714
Pubmed	Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK.	NCOR1 NCOR2	1.64e-05	4	58	2	15878880
Pubmed	FBI-1 functions as a novel AR co-repressor in prostate cancer cells.	NCOR1 NCOR2	1.64e-05	4	58	2	20812024
Pubmed	The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3.	NCOR1 NCOR2	1.64e-05	4	58	2	11509652
Pubmed	The retinoid X receptor binding to the thyroid hormone receptor: relationship with cofactor binding and transcriptional activity.	NCOR1 NCOR2	1.64e-05	4	58	2	19211732
Pubmed	A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.	NCOR1 NCOR2	1.64e-05	4	58	2	20543827
Pubmed	GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression.	NCOR1 NCOR2	1.64e-05	4	58	2	26712002
Pubmed	Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex.	NCOR1 NCOR2	1.64e-05	4	58	2	26712006
Pubmed	MicroRNAs are mediators of androgen action in prostate and muscle.	NCOR1 NCOR2	1.64e-05	4	58	2	21048966
Pubmed	Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.	NCOR1 NCOR2	1.64e-05	4	58	2	9819405
Pubmed	Vitamin D-dependent recruitment of corepressors to vitamin D/retinoid X receptor heterodimers.	NCOR1 NCOR2	1.64e-05	4	58	2	18362166
Pubmed	Dichotomous engagement of HDAC3 activity governs inflammatory responses.	NCOR1 NCOR2	1.64e-05	4	58	2	32760002
Pubmed	A cell type-specific expression map of NCoR1 and SMRT transcriptional co-repressors in the mouse brain.	NCOR1 NCOR2	1.64e-05	4	58	2	32072640
Pubmed	EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells.	EGFR IRF1	1.64e-05	4	58	2	17918184
Pubmed	Direct association between the CREB-binding protein (CBP) and nuclear receptor corepressor (N-CoR).	NCOR1 NCOR2	1.64e-05	4	58	2	17073437
Pubmed	The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.	NCOR1 NCOR2	1.64e-05	4	58	2	16024608
Pubmed	Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint.	NCOR1 NCOR2	1.64e-05	4	58	2	19595715
Pubmed	The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11.	EGFR RNF11	1.64e-05	4	58	2	18724389
Pubmed	Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1.	NCOR1 NCOR2	1.64e-05	4	58	2	16121196
Pubmed	EGF-responsive neural stem cells are a transient population in the developing mouse spinal cord.	EGFR FGFR2	1.64e-05	4	58	2	11553295
Pubmed	A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation.	NCOR1 NCOR2	1.64e-05	4	58	2	12840002
Pubmed	Nuclear receptor coregulator SNP discovery and impact on breast cancer risk.	NCOR1 NCOR2	1.64e-05	4	58	2	20003447
Pubmed	p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation.	EGFR NECTIN1 FGFR2	1.73e-05	30	58	3	16524929
Pubmed	Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases.	TYK2 EGFR	2.72e-05	5	58	2	9038232
Pubmed	ERbeta Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus.	NCOR1 NCOR2	2.72e-05	5	58	2	12904255
Pubmed	Genomic profiling in a homogeneous molecular subtype of non-small cell lung cancer: An effort to explore new drug targets.	EGFR FGFR2	2.72e-05	5	58	2	26853422
Pubmed	RCAN 1 and 3 proteins regulate thymic positive selection.	RCAN3 RCAN2	2.72e-05	5	58	2	25783055
Pubmed	Epigenetic control of a VDR-governed feed-forward loop that regulates p21(waf1/cip1) expression and function in non-malignant prostate cells.	NCOR1 NCOR2	2.72e-05	5	58	2	21088000
Pubmed	Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells.	NCOR1 NCOR2	2.72e-05	5	58	2	23703729
Pubmed	Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.	NCOR1 NCOR2	2.72e-05	5	58	2	15531890
Pubmed	Combinatorial roles of the nuclear receptor corepressor in transcription and development.	NCOR1 NCOR2	2.72e-05	5	58	2	11030619
Pubmed	The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures.	NCOR1 NCOR2	2.72e-05	5	58	2	16033423
Pubmed	Botch promotes neurogenesis by antagonizing Notch.	EGFR FGFR2	2.72e-05	5	58	2	22445366
Pubmed	Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells.	NCOR1 NCOR2	2.72e-05	5	58	2	15729358
Pubmed	Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas.	NCOR1 NCOR2	2.72e-05	5	58	2	21143702
Pubmed	The histone deacetylase-3 complex contains nuclear receptor corepressors.	NCOR1 NCOR2	2.72e-05	5	58	2	10860984
Pubmed	A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.	NCOR1 NCOR2	2.72e-05	5	58	2	10809664
Pubmed	Mouse germline restriction of Oct4 expression by germ cell nuclear factor.	NCOR1 NCOR2	2.72e-05	5	58	2	11702949
Pubmed	Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.	NCOR1 NCOR2	2.72e-05	5	58	2	7566114
Pubmed	Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.	NCOR1 NCOR2	2.72e-05	5	58	2	15175761
Pubmed	Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor.	NCOR1 NCOR2	2.72e-05	5	58	2	14593076
Pubmed	Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.	NCOR1 NCOR2	2.72e-05	5	58	2	11865059
Pubmed	Nectin-1 binds and signals through the fibroblast growth factor receptor.	NECTIN1 FGFR2	2.72e-05	5	58	2	22955284
Pubmed	Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction.	NCOR1 NCOR2	2.72e-05	5	58	2	29033129
Pubmed	The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.	USP6 TBC1D3	2.72e-05	5	58	2	12612085
Pubmed	Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex.	NCOR1 NCOR2	2.72e-05	5	58	2	16712523
Interaction	TBC1D3L interactions	TBC1D3L EGFR	7.58e-06	2	56	2	int:TBC1D3L
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	5.77e-17	149	58	11	chr17q12
Cytoband	17q12	TBC1D3 TBC1D3H TBC1D3C TBC1D3B TBC1D3F	1.76e-07	99	58	5	17q12
Cytoband	8q22.2	SPAG1 VPS13B	3.90e-04	23	58	2	8q22.2
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	NCOR1 NCOR2 MYB	1.22e-04	53	33	3	532
GeneFamily	Calcium voltage-gated channel subunits	CACNG8 CACNA1I	1.02e-03	26	33	2	253
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	TYK2 PTPN21	3.75e-03	50	33	2	1293
CoexpressionAtlas	Mesoderm Day 15_vs_Mesoderm Day 30-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	2.63e-12	90	58	9	PCBC_ratio_MESO-15_vs_MESO-30_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TYK2 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TRPM2 TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	2.35e-10	281	58	11	PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05	TYK2 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TRPM2 TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	2.35e-10	281	58	11	PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G PLEKHG5 TBC1D3C TBC1D3B TBC1D3K TBC1D3F BAHCC1	9.30e-10	320	58	11	PCBC_ratio_MESO-5_vs_DE_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-reprogram_OSKM-L_vs_Endoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	6.04e-09	213	58	9	PCBC_ratio_DE_from-OSKM-L_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-method_mRNA_vs_Endoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	6.04e-09	213	58	9	PCBC_ratio_DE_from-mRNA_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	DE cord blood_vs_DE blastocyst-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.83e-08	242	58	9	PCBC_ratio_DE cord blood_vs_DE blastocyst_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05	DENND2A TBC1D3 TBC1D3H TBC1D3L TBC1D3D TRPM2 PTPN21 TBC1D3G PLEKHG5 TBC1D3C TBC1D3B RCAN3 RCAN2 TBC1D3K TBC1D3F BAHCC1	4.74e-08	1153	58	16	PCBC_ratio_MESO-5_vs_SC_cfr-2X-p05
CoexpressionAtlas	Ectoderm Differentiated Cells_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	DENND2A DMXL2 TBC1D3 TBC1D3H TBC1D3L TBC1D3D NECTIN1 SEMA3B FGFR2 TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F BAHCC1	1.28e-07	1075	58	15	PCBC_ratio_ECTO_vs_DE_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 15_vs_Mesoderm Day 5-Confounder_removed-fold2.0_adjp0.05	TYK2 AFMID TBC1D3 TBC1D3H TBC1D3L TBC1D3D EGFR SEMA3B TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	3.84e-06	1049	58	13	PCBC_ratio_MESO-15_vs_MESO-5_cfr-2X-p05
CoexpressionAtlas	Ectoderm Differentiated Cells_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05	DENND2A DMXL2 TBC1D3 TBC1D3H TBC1D3L TBC1D3D SEMA3B FGFR2 PTPN21 TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F BAHCC1	6.32e-06	1466	58	15	PCBC_ratio_ECTO_vs_SC_cfr-2X-p05
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRPM2 FOXI2 HMGB3 PWWP3B RCAN2	2.59e-06	167	58	5	49d9220f22d10ff06c0512c9c40c26ad51728e4f
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRPM2 FOXI2 HMGB3 PWWP3B RCAN2	2.59e-06	167	58	5	7ec032a98a13504d15c7e3a4e259278d07f40180
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRPM2 FOXI2 HMGB3 PWWP3B RCAN2	2.59e-06	167	58	5	5e3588eee73693a996bb4846427cf0038ceafbca
ToppCell	Nasal_Brush-Epithelial-Ionocytes\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	USP6 MAFA FOXI2 PCDH17 RCAN2	3.00e-06	172	58	5	04fabb40fa9357d8902f3b04adc15231626cd9f8
ToppCell	Nasal_Brush-Epithelial-Ionocytes\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	USP6 MAFA FOXI2 PCDH17 RCAN2	3.00e-06	172	58	5	dd3a23dc78dc6939f41126f8d7bd23a2e4713647
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EGFR TRPM2 FOXI2 HMGB3 RCAN2	4.16e-06	184	58	5	a60802e11dcc5f932811260b08a95a32f60f6b19
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EGFR TRPM2 FOXI2 HMGB3 RCAN2	4.16e-06	184	58	5	39c230d32e4259bc784e0edfd9e2884c96898564
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EGFR TRPM2 FOXI2 HMGB3 RCAN2	4.16e-06	184	58	5	2a2fb691cc9414ef5b06c26239d2da03d6d7e5c2
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EGFR HMGB3 FGFR2 PCDH17	5.23e-05	157	58	4	6ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL16A1 EGFR CPEB1 DNAH11	5.49e-05	159	58	4	7ed659163f45e0c4df4782997c0786900c8186c8
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VSIG2 PTPRN MAFA CFAP65	6.80e-05	168	58	4	38ba7737ae0afffcbd3aa499403e83c24a922127
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TBC1D3L PTPRN MAFA CFAP65	6.80e-05	168	58	4	0f736d58cb0ff042fa3ce58e36bde37b6976f8fc
ToppCell	Ciliated_cells-A-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	PCDH17 MYB CPEB1 DNAH11	7.12e-05	170	58	4	8b7ef1464ea589886b575ebad5447b085cbdcdba
ToppCell	Control-Epithelial_cells-Airway_basal\|Control / group, cell type (main and fine annotations)	EGFR NECTIN1 HMGB3 FGFR2	7.28e-05	171	58	4	3965ced4be6db14265a90673502fceee425837ca
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EGFR FOXI2 PCDH17 RCAN2	7.79e-05	174	58	4	b7f5492ce8098f7eb0aef30ee558d00738d59d0e
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	EGFR FOXI2 PCDH17 RCAN2	7.79e-05	174	58	4	71730503be3d9c839c4c9e950145e2101d682a1c
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	EGFR FOXI2 PCDH17 RCAN2	7.79e-05	174	58	4	ee8ac51fa0b426ad7b7453371bb79c8bf8c1d358
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EGFR FOXI2 PCDH17 RCAN2	7.79e-05	174	58	4	cafe4d6b5f08d8888e9db6e196c66df991c03e7b
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 VSIG2 PCDH17 BAHCC1	8.14e-05	176	58	4	27e5115fae5f0f63b333bc99fbf6a6d4c9182c46
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UBR1 EGFR NECTIN1 PLEKHG5	8.32e-05	177	58	4	a235ff4f37a7622216526191efc4832fb8ed6957
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EGFR NECTIN1 HMGB3 FGFR2	8.32e-05	177	58	4	cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EGFR NECTIN1 HMGB3 FGFR2	8.32e-05	177	58	4	ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPRN MAFA RCAN3 CFAP65	8.32e-05	177	58	4	43dce527392f3b8364bb6a55268ce9d6518d3a29
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EGFR HMGB3 FGFR2 PCDH17	8.51e-05	178	58	4	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRN TRPM2 PWWP3B CPEB1	8.51e-05	178	58	4	30ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCell	Epithelial-basal_cell\|World / Lineage, Cell type, age group and donor	EGFR NECTIN1 HMGB3 FGFR2	8.69e-05	179	58	4	d9be6647ec7b22747dc00dce4ea307b6af412dfa
ToppCell	5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPRN FOXI2 HMGB3 RCAN2	8.88e-05	180	58	4	5286e66ff6b7154390b3e9c189704a71d56bc89c
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VSIG2 PTPRN MAFA CFAP65	8.88e-05	180	58	4	d553aba594f5304f1c09ff9c6d49b64cd7ee7850
ToppCell	5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPRN FOXI2 HMGB3 RCAN2	8.88e-05	180	58	4	2b6b295b5c21b829828afae9ab4c3eb9233f6f45
ToppCell	5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPRN FOXI2 HMGB3 RCAN2	8.88e-05	180	58	4	bf587387145a2b5e83766fbccf76eecc6d5e8241
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EGFR FOXI2 PTPN21 RCAN2	9.07e-05	181	58	4	40df0afcb6848202da54670e84f22d7c3a515d01
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EGFR FOXI2 PTPN21 RCAN2	9.07e-05	181	58	4	2b53a65ca5616a7b9f64232c3e0b7212d1e2f063
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EGFR FOXI2 PTPN21 RCAN2	9.07e-05	181	58	4	6aef84616e8d2faf54b7e9e6cd02f33c3066dabc
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EGFR FOXI2 PTPN21 RCAN2	9.07e-05	181	58	4	40d3829ae4aaf81e8616c3499ff8933137fc1cc4
ToppCell	10x5'-bone_marrow-Lymphocytic_B-Pre-B\|bone_marrow / Manually curated celltypes from each tissue	DENND2A MAFA MYB BAHCC1	9.27e-05	182	58	4	a5fd392178c2f533e265d2e3ce63b90c2553e4c1
ToppCell	cellseq-Epithelial-Epithelial_Neuro-Secretory-Ionocyte\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TRPM2 FOXI2 HMGB3 RCAN2	9.27e-05	182	58	4	6e7dac78dc030f74e546b9f6db07556e9bb13ac2
ToppCell	COPD-Epithelial-ATI\|World / Disease state, Lineage and Cell class	VSIG2 EGFR SEMA3B PTPN21	9.27e-05	182	58	4	e95d946a43b1579af199900bb0e3eacbb9d65300
ToppCell	Children_(3_yrs)-Immune-enucleated_erythrocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SPAG1 SEMA3B HMGB3 PCDH17	9.27e-05	182	58	4	3fddadb2ff75013ec6eeb415872667a6bae1da2d
ToppCell	cellseq-Epithelial-Epithelial_Neuro-Secretory-Ionocyte-Ionocyte\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TRPM2 FOXI2 HMGB3 RCAN2	9.27e-05	182	58	4	cd972d30519db706477c6b0c901165b81b74abed
ToppCell	Adult-Epithelial-basal_cell\|Adult / Lineage, Cell type, age group and donor	EGFR HMGB3 PWWP3B FGFR2	9.47e-05	183	58	4	00a6b19ca49e3b8e0d1cd387a3515b0ff4b81c81
ToppCell	Control-Epithelial-ATI\|World / Disease state, Lineage and Cell class	VSIG2 EGFR SEMA3B PTPN21	9.87e-05	185	58	4	0563d5042bb96ecce8446fbf26d05ef7a45e23c5
ToppCell	COPD-Epithelial-ATI\|COPD / Disease state, Lineage and Cell class	VSIG2 EGFR SEMA3B PTPN21	1.01e-04	186	58	4	df0977f6f48a2d4e11b59971f098b01204242f0f
ToppCell	droplet-Heart-HEART-1m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL16A1 SEMA3B GRIK4 DNAH11	1.01e-04	186	58	4	fddc6b93f98b10aaf8d4ebc142b46d8213f3129d
ToppCell	Control-Epithelial-ATI\|Control / Disease state, Lineage and Cell class	VSIG2 EGFR SEMA3B PTPN21	1.03e-04	187	58	4	fdd1c57b61ca9392ac27661a82729f37593df63c
ToppCell	moderate-Epithelial-Ionocyte\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	EGFR FOXI2 PTPN21 RCAN2	1.03e-04	187	58	4	3e3fe2d5712a0ac477cddefe56705d4b8d8f7eac
ToppCell	COVID-19-Epithelial_cells-Airway_basal\|COVID-19 / group, cell type (main and fine annotations)	EGFR NECTIN1 HMGB3 FGFR2	1.03e-04	187	58	4	8407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCell	droplet-Heart-HEART-1m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL16A1 SEMA3B GRIK4 DNAH11	1.07e-04	189	58	4	a618a1ddf5097a010c6c2c7341f3a0bd46a29c02
ToppCell	droplet-Heart-HEART-1m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL16A1 SEMA3B GRIK4 DNAH11	1.07e-04	189	58	4	4e61f9cd1c06bddb47ebf98affc0f97770e26e8c
ToppCell	ASK440-Epithelial-Secretory\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	EGFR SEMA3B HMGB3 FGFR2	1.16e-04	193	58	4	50e98d91697c7af6a3de39e52edde6dd2b67b512
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DENND2A CACNG8 EGFR PCDH17	1.19e-04	194	58	4	8b81f039f5b25d35a4d5a41b27d4d9360ba22f15
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRPM2 FOXI2 PWWP3B PCDH17	1.23e-04	196	58	4	ef650ff106a76c1e926e13c7f002fbc452cc48ae
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Mucous-Mucous\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	VSIG2 HMGB3 HDLBP CFAP65	1.23e-04	196	58	4	357a5440aeebf69688bfe9fbc8585950ad00906b
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRPM2 FOXI2 PWWP3B PCDH17	1.23e-04	196	58	4	72b6a68ee760599ea86cd2d712bfd17b7b4ee417
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Mucous\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	VSIG2 HMGB3 HDLBP CFAP65	1.23e-04	196	58	4	98e3f9c886063def16c74ab75fc81511a7872f1c
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Basal_1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	EGFR HMGB3 PWWP3B RCAN2	1.28e-04	198	58	4	f632342e1e8911dd82b5df171776a84c7dc3f931
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NECTIN1 FGFR2 PCDH17 CPEB1	1.31e-04	199	58	4	5d2e85e40b6b52b1809e680b952913d77215b3d0
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NECTIN1 FGFR2 PCDH17 CPEB1	1.31e-04	199	58	4	9dd4b17fb8c70ab9e126b23b72600463f3db832d
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EGFR NECTIN1 HMGB3 FGFR2	1.31e-04	199	58	4	4099df3c052a9536d72ba01492317be7d83a79ad
ToppCell	distal-Epithelial-Mucous-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	VSIG2 HMGB3 PWWP3B FGFR2	1.31e-04	199	58	4	35fb7bd35e53d8ca189fe8c7744211a5201081f6
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NECTIN1 FGFR2 PCDH17 CPEB1	1.31e-04	199	58	4	6fb5f931e6217142de38c1fffc011e63bda4772b
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NECTIN1 FGFR2 PCDH17 CPEB1	1.31e-04	199	58	4	1bb5797e8e0552bf9b44bf4c958d1aa6dbe6c756
ToppCell	distal-2-Epithelial-Basal\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NECTIN1 SEMA3B HMGB3 FGFR2	1.33e-04	200	58	4	9beb128841c50241aa819261f21bf66f881ea125
Drug	2-Aminobenzenesulfonamide [3306-62-5]; Down 200; 23.2uM; MCF7; HT_HG-U133A	YTHDC2 FGFR2 PTPN21 VPS13B RCAN3 MYB	4.37e-06	192	51	6	3400_DN
Disease	Endometrial adenocarcinoma	EGFR FGFR2	1.68e-05	4	50	2	C1153706
Disease	myelofibrosis (implicated_via_orthology)	NCOR2 MYB	4.20e-05	6	50	2	DOID:4971 (implicated_via_orthology)
Disease	macrophage inflammatory protein 1b measurement	TBC1D3 FOXI2 TBC1D3B TBC1D3F	8.43e-05	136	50	4	EFO_0008219
Disease	estrogen-receptor positive breast cancer	IRF1 FGFR2	1.01e-04	9	50	2	EFO_1000649
Disease	Head and Neck Carcinoma	EGFR FGFR2	1.26e-04	10	50	2	C3887461
Disease	Gastric cancer	IRF1 FGFR2	1.53e-04	11	50	2	cv:C0024623
Disease	Neoplasm of stomach	IRF1 FGFR2	1.53e-04	11	50	2	cv:C0038356
Disease	GASTRIC CANCER	IRF1 FGFR2	1.53e-04	11	50	2	613659
Disease	Nonorganic psychosis	TRPM2 GRIK4 FGFR2	2.22e-04	69	50	3	C0349204
Disease	Endometrial Carcinoma	EGFR SEMA3B FGFR2	2.51e-04	72	50	3	C0476089
Disease	Lung cancer	EGFR IRF1	2.53e-04	14	50	2	cv:C0242379
Disease	LUNG CANCER	EGFR IRF1	2.53e-04	14	50	2	211980
Disease	Neoplasm of lung	EGFR IRF1	2.53e-04	14	50	2	cv:C0024121
Disease	Down syndrome (implicated_via_orthology)	RCAN3 RCAN2	2.91e-04	15	50	2	DOID:14250 (implicated_via_orthology)
Disease	Benign neoplasm of stomach	IRF1 FGFR2	3.77e-04	17	50	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	IRF1 FGFR2	3.77e-04	17	50	2	C0496905
Disease	Carcinoma in situ of stomach	IRF1 FGFR2	3.77e-04	17	50	2	C0154060
Disease	thyroxine measurement	DHX15 NCOR1 PWWP3B	3.82e-04	83	50	3	EFO_0005130
Disease	Malignant neoplasm of endometrium	EGFR FGFR2	4.23e-04	18	50	2	C0007103
Disease	Carcinoma in situ of endometrium	EGFR FGFR2	4.23e-04	18	50	2	C0346191
Disease	CCL4 measurement	TBC1D3 TBC1D3F	5.24e-04	20	50	2	EFO_0004751
Disease	fetal hemoglobin measurement	YTHDC2 MYB	5.79e-04	21	50	2	EFO_0004576
Disease	Stomach Carcinoma	IRF1 FGFR2	5.79e-04	21	50	2	C0699791
Disease	Tinnitus, wellbeing measurement	VSIG2 FOXI2 PTPN21	5.85e-04	96	50	3	EFO_0007869, HP_0000360
Disease	portal hypertension (biomarker_via_orthology)	FGFR2 CPEB1	6.36e-04	22	50	2	DOID:10762 (biomarker_via_orthology)
Disease	Psychotic Disorders	TRPM2 GRIK4 FGFR2	6.79e-04	101	50	3	C0033975
Disease	Carcinoma of lung	EGFR IRF1	6.96e-04	23	50	2	C0684249
Disease	Intrahepatic Cholangiocarcinoma	EGFR FGFR2	7.58e-04	24	50	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	EGFR FGFR2	7.58e-04	24	50	2	C3805278
Disease	Cholangiocarcinoma	EGFR FGFR2	8.91e-04	26	50	2	C0206698
Disease	platelet crit	TYK2 DENND2A EGFR IRF1 BTBD2 RCAN2 MYB	1.06e-03	952	50	7	EFO_0007985
Disease	Squamous cell carcinoma of lung	EGFR FGFR2	1.35e-03	32	50	2	C0149782
Disease	Head and Neck Neoplasms	EGFR FGFR2	1.44e-03	33	50	2	C0018671
Disease	prostate cancer (implicated_via_orthology)	FGFR2 HDLBP	1.44e-03	33	50	2	DOID:10283 (implicated_via_orthology)
Disease	verbal-numerical reasoning measurement	DMXL2 COL16A1 CACNA1I	1.44e-03	131	50	3	EFO_0008394
Disease	lung disease (biomarker_via_orthology)	EGFR IRF1	1.62e-03	35	50	2	DOID:850 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
YAHLKAEGKGERRPG	BAHCC1	441	Q9P281
HPGYLVEKGEKGDQG	COL16A1	966	Q07092
TKKTKEDYGHPPREG	DNAH11	4411	Q96DT5
LGYPGGKAKVIHKES	DMXL2	2646	Q8TDJ6
EDYPSGKKRAGTDGK	DHX15	11	O43143
GHPEKYGKGEPKTES	CASP8AP2	286	Q9UKL3
KLGPGEKYELHAGTE	RCAN2	141	Q14206
SKLGPGEKYELHAGT	RCAN3	176	Q9UKA8
EYSHPQLGGGKGKKK	PCDH17	746	O14917
HTGRYKAGEKEPDPK	IRF1	61	P10914
KSLLHVPYGDGEGEK	AFMID	61	Q63HM1
IKHVEKNGSKYGPDG	FGFR2	291	P21802
DSLPKGHVIYEGKKG	NCOR2	1261	Q9Y618
GYEKEGLGDRGEKPA	PTPRN	311	Q16849
KEKYEKLAGRGGPGS	MAFA	311	Q8NHW3
PEHYPGLGKKEEGEE	CFAP65	1751	Q6ZU64
SKYGLKHLAEEKPDG	CBWD2	171	Q8IUF1
KKVPRDEDDPGKGNY	FOXI2	161	Q6ZQN5
GDYKGEEKDRAPGEK	ISM2	251	Q6H9L7
YDGLLPKSGKRHLGK	MYB	26	P10242
GPEEAEGLRYGHKKS	PTPN21	686	Q16825
LLGAEEKEYHAEGGK	EGFR	861	P00533
GEPGPKRDEEKKNHY	CACNG8	186	Q8WXS5
RTFKHAGEGDKDGKP	DENND2A	271	Q9ULE3
FYEDKKGVLHAGPGR	DENND11	191	A4D1U4
AKEPRHYHGKTKGQG	CACNA1I	481	Q9P0X4
YDREMKDYGPAKGGK	HMGB3	71	O15347
GIDTDKHKYPIGSGR	CPEB1	461	Q9BZB8
GGKCPKEEDHRAKGL	GRIK4	786	Q16099
LKGPDSHYGTKGLRK	BTBD2	471	Q9BX70
PKGVYDPGRDGSEKK	RNF11	81	Q9Y3C5
HKKYRKDEGDLPGCL	PWWP3B	131	Q5H9M0
ADAKKDPAFGGKHEA	NCOR1	141	O75376
KYEKGHRAGLPEDKG	TBC1D3L	21	B9A6J9
STRLHKGDEGYGRPK	ABRA	276	Q8N0Z2
KGDEGYGRPKEGTKT	ABRA	281	Q8N0Z2
KYEKGHRAGLPEDKG	TBC1D3B	21	A6NDS4
KYEKGHRAGLPEDKG	TBC1D3H	21	P0C7X1
HYLRVKAPAKPGDEG	PLEKHG5	141	O94827
KYEKGHRAGLPEDKG	TBC1D3F	21	A6NER0
IEDGKGKSPYDPRHR	SEMA3B	161	Q13214
GGRKKTEEPGDSYHV	TRPM2	1226	O94759
RKHEDGGGDKKPAEP	SPAG1	356	Q07617
KKPGVSGHGVYELKD	UBR1	811	Q8IWV7
KYEKGHRAGLPEDKG	TBC1D3E	21	A0A087X179
KYKDRGILHPKRGTE	YTHDC2	1231	Q9H6S0
KPGGKRKYKTRHLEG	TOPORS	791	Q9NS56
YRGKLSKPKIHGDGV	VPS13B	2101	Q7Z7G8
KYEKGHRAGLPEDKG	TBC1D3D	21	A0A087WVF3
PEYHKFLIGKGGGKI	HDLBP	736	Q00341
AKGLLDKVKDGGYRP	ZBED1	501	O96006
GKKPKETYGGSDLRE	VSIG2	271	Q96IQ7
KYEKGHRAGLPEDKG	TBC1D3G	21	Q6DHY5
KYEKGHRAGLPEDKG	TBC1D3	21	Q8IZP1
KYEKGHRAGLPEDKG	TBC1D3K	21	A0A087X1G2
KYDKGHRAGLPEDKG	USP6	21	P35125
KYEKGHRAGLPEDKG	TBC1D3I	21	A0A087WXS9
KYEKGHRAGLPEDKG	TBC1D3C	21	Q6IPX1
YLKKIRDLGEGHFGK	TYK2	896	P29597
RKVGGPHPKYDEDAK	NECTIN1	451	Q15223