Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH17 DNAH9 DNAH11

5.40e-0518833GO:0008569
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH17 DNAH9 DNAH11

2.10e-0428833GO:0051959
DomainAcetyltransf_13

ESCO2 ESCO1

1.86e-052812PF13880
Domainzf-C2H2_3

ESCO2 ESCO1

1.86e-052812PF13878
DomainESCO_Acetyltransf_dom

ESCO2 ESCO1

1.86e-052812IPR028009
DomainAcTrfase_ESCO_Znf_dom

ESCO2 ESCO1

1.86e-052812IPR028005
Domain-

DST MACF1

2.76e-0468123.90.1290.10
DomainGAR

DST MACF1

2.76e-046812PS51460
Domain-

DST MACF1

2.76e-0468123.30.920.20
DomainGAS_dom

DST MACF1

2.76e-046812IPR003108
DomainGAS2

DST MACF1

2.76e-046812PF02187
DomainGAS2

DST MACF1

2.76e-046812SM00243
DomainUmuC

ESCO2 ESCO1

2.76e-046812IPR001126
DomainPlectin_repeat

DST MACF1

3.85e-047812IPR001101
DomainPlectin

DST MACF1

3.85e-047812PF00681
DomainPLEC

DST MACF1

3.85e-047812SM00250
DomainDHC_N1

DNAH9 DNAH11

5.11e-048812PF08385
DomainDynein_heavy_dom-1

DNAH9 DNAH11

5.11e-048812IPR013594
DomainDOCK_C

DOCK4 DOCK9

9.96e-0411812IPR010703
DomainDHR-1_domain

DOCK4 DOCK9

9.96e-0411812IPR027007
DomainDHR_2

DOCK4 DOCK9

9.96e-0411812PS51651
DomainDHR_1

DOCK4 DOCK9

9.96e-0411812PS51650
DomainDOCK-C2

DOCK4 DOCK9

9.96e-0411812PF14429
DomainDHR-2

DOCK4 DOCK9

9.96e-0411812IPR027357
DomainDHR-2

DOCK4 DOCK9

9.96e-0411812PF06920
DomainDOCK

DOCK4 DOCK9

9.96e-0411812IPR026791
DomainQuinoprotein_ADH-like_supfam

WDR75 WDR88 FBXW2

1.57e-0353813IPR011047
DomainDynein_heavy_chain_D4_dom

DNAH9 DNAH11

1.63e-0314812IPR024317
DomainDynein_HC_stalk

DNAH9 DNAH11

1.63e-0314812IPR024743
DomainDynein_heavy_dom-2

DNAH9 DNAH11

1.63e-0314812IPR013602
DomainDHC_N2

DNAH9 DNAH11

1.63e-0314812PF08393
DomainMT

DNAH9 DNAH11

1.63e-0314812PF12777
DomainAAA_8

DNAH9 DNAH11

1.63e-0314812PF12780
DomainTIL_dom

LRP2 MUC2

1.63e-0314812IPR002919
DomainATPase_dyneun-rel_AAA

DNAH9 DNAH11

1.63e-0314812IPR011704
DomainAAA_5

DNAH9 DNAH11

1.63e-0314812PF07728
DomainDHC_fam

DNAH9 DNAH11

1.88e-0315812IPR026983
DomainDynein_heavy_dom

DNAH9 DNAH11

1.88e-0315812IPR004273
DomainDynein_heavy

DNAH9 DNAH11

1.88e-0315812PF03028
DomainKinase-like_dom

TGFBR2 AKT3 DST PIK3CA MAP3K10 MACF1 MELK ARAF

2.40e-03542818IPR011009
PathwayKEGG_MEDICUS_REFERENCE_NRG_ERBB4_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA NRG3

1.37e-0511633M47756
PathwayREACTOME_SIGNALING_BY_ERBB2

USP8 AKT3 PIK3CA NRG3

4.30e-0544634MM14520
PathwayREACTOME_SIGNALING_BY_ERBB2

USP8 AKT3 PIK3CA NRG3

7.15e-0550634M553
PathwayKEGG_COLORECTAL_CANCER

TGFBR2 AKT3 PIK3CA ARAF

1.66e-0462634M14631
PathwayKEGG_MEDICUS_REFERENCE_COHESIN_ACETYLATION

ESCO2 ESCO1

1.95e-045632M49003
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING

USP8 AKT3 NRG3

2.06e-0426633MM15501
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH17 DNAH9 DNAH11

2.30e-0427633M47755
PathwayKEGG_PANCREATIC_CANCER

TGFBR2 AKT3 PIK3CA ARAF

2.66e-0470634M9726
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING

USP8 AKT3 NRG3

2.86e-0429633M27756
PathwayKEGG_CHRONIC_MYELOID_LEUKEMIA

TGFBR2 AKT3 PIK3CA ARAF

3.13e-0473634M321
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PI3K_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

4.07e-047632M47407
PathwayKEGG_MEDICUS_REFERENCE_ACH_CHRN_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

4.07e-047632M47790
PathwayWP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION

AKT3 PIK3CA ITPR1

4.22e-0433633M39745
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

5.41e-048632M47399
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

5.41e-048632M47394
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

5.41e-048632M47395
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

5.41e-048632M47404
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

5.41e-048632M47405
PathwayKEGG_MEDICUS_REFERENCE_P4_PR_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

5.41e-048632M47803
PathwayKEGG_MEDICUS_VARIANT_TGFA_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

5.41e-048632M47482
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

5.41e-048632M47498
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_RET_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

5.41e-048632M47715
PathwayREACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING

PIK3CA NRG3

5.41e-048632MM14532
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

AKT3 PIK3CA ITPR1

5.47e-0436633M1315
PathwayKEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION

AKT3 PIK3CA ANAPC5 ARAF

5.59e-0485634M3578
PathwayKEGG_ERBB_SIGNALING_PATHWAY

AKT3 PIK3CA NRG3 ARAF

6.11e-0487634M12467
PathwayWP_PANCREATIC_ADENOCARCINOMA_PATHWAY

TGFBR2 AKT3 PIK3CA ARAF

6.66e-0489634M39732
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

6.93e-049632M47397
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

6.93e-049632M47392
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

6.93e-049632M47391
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

6.93e-049632M47402
PathwayKEGG_MEDICUS_REFERENCE_MEMBRANE_INITIATED_PROGESTERONE_SIGNALING_PATHWAY

AKT3 PIK3CA

6.93e-049632M47802
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_MET_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

6.93e-049632M47490
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

6.93e-049632M47481
PathwayWP_ERBB_SIGNALING

AKT3 PIK3CA NRG3 ARAF

7.54e-0492634M39715
PathwayKEGG_MEDICUS_VARIANT_EGFR_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

8.64e-0410632M47400
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

8.64e-0410632M47401
PathwayKEGG_MEDICUS_REFERENCE_CD80_CD86_CD28_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

8.64e-0410632M47615
PathwayREACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING

PIK3CA NRG3

8.64e-0410632M568
PathwayKEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT

DNAH17 DNAH9 DNAH11

9.24e-0443633M47669
PathwayKEGG_MEDICUS_ENV_FACTOR_NICOTINE_NNK_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

1.05e-0311632M47797
PathwayKEGG_MEDICUS_REFERENCE_KITLG_KIT_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

1.05e-0311632M47403
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

1.05e-0311632M47406
PathwayREACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION

ESCO2 ESCO1

1.05e-0311632M27177
PathwayREACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION

ESCO2 ESCO1

1.05e-0311632MM14891
PathwayKEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

1.05e-0311632M47484
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

1.05e-0311632M47499
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01339

AKT3 PIK3CA

1.05e-0311632M47791
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

1.05e-0311632M47501
PathwaySIG_CHEMOTAXIS

AKT3 PIK3CA ITPR1

1.06e-0345633M5193
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH17 DNAH9 DNAH11

1.06e-0345633M47670
PathwayWP_ERBB_SIGNALING_PATHWAY

AKT3 NRG3 ARAF

1.13e-0346633MM15950
PathwaySIG_BCR_SIGNALING_PATHWAY

AKT3 PIK3CA ITPR1

1.13e-0346633M8626
PathwayKEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

1.26e-0312632M47393
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01350

AKT3 PIK3CA

1.26e-0312632M47798
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY

AKT3 PIK3CA

1.26e-0312632M47558
PathwayKEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY

AKT3 PIK3CA

1.26e-0312632M47559
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING

USP8 AKT3

1.26e-0312632MM14550
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

1.49e-0313632M47398
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

1.49e-0313632M47603
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING

USP8 AKT3

1.49e-0313632M549
PathwayKEGG_ENDOMETRIAL_CANCER

AKT3 PIK3CA ARAF

1.61e-0352633M19877
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

1.73e-0314632M47390
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGFR_PI3K_NFKB_SIGNALING_PATHWAY

AKT3 PIK3CA

1.73e-0314632M47467
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY

AKT3 PIK3CA

1.73e-0314632M47536
PathwayREACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING

PIK3CA NRG3

1.73e-0314632MM14761
PathwayKEGG_NON_SMALL_CELL_LUNG_CANCER

AKT3 PIK3CA ARAF

1.79e-0354633M19818
PathwayWP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS

AKT3 PIK3CA MAP3K10 ITPR1

1.96e-03119634M48309
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

1.99e-0315632M47389
PathwayKEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

1.99e-0315632M47663
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY

AKT3 PIK3CA

1.99e-0315632M47475
PathwayWP_RIOK1_AND_RIOK2_IN_EGFR_AND_PI3KMEDIATED_TUMORIGENESIS

AKT3 PIK3CA

1.99e-0315632M48306
PathwayKEGG_ACUTE_MYELOID_LEUKEMIA

AKT3 PIK3CA ARAF

2.10e-0357633M19888
PathwayREACTOME_SIGNALING_BY_GPCR

GHSR AKT3 DRD2 PIK3CA NPSR1 C5 TAS2R31 BDKRB2 ITPR1

2.18e-03646639MM14962
PathwayREACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING

PIK3CA NRG3

2.27e-0316632M570
PathwayWP_MET_IN_TYPE_1_PAPILLARY_RENAL_CELL_CARCINOMA

AKT3 PIK3CA ARAF

2.31e-0359633M39750
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

GHSR PIK3CA NPSR1 BDKRB2 ITPR1

2.44e-03210635MM15043
PathwaySA_PTEN_PATHWAY

AKT3 PIK3CA

2.56e-0317632M12771
PathwaySA_TRKA_RECEPTOR

AKT3 PIK3CA

2.56e-0317632M18895
PathwayWP_ENDOMETRIAL_CANCER

AKT3 PIK3CA ARAF

2.79e-0363633M39623
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

GHSR PIK3CA NPSR1 BDKRB2 ITPR1

2.81e-03217635M18437
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

ESCO2 ZWILCH AKT3 WDR75 ALDH1L2 DOCK9 UGGT1 DTL LRP2 MACF1 RTN4IP1 XPA SBNO2 LRRC71 ITPR1

3.88e-081084831511544199
Pubmed

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

DNAH17 DNAH9 DNAH11

4.56e-07783331178125
Pubmed

Temporal Regulation of ESCO2 Degradation by the MCM Complex, the CUL4-DDB1-VPRBP Complex, and the Anaphase-Promoting Complex.

ESCO2 MCM10 ESCO1

2.13e-061183330100344
Pubmed

A protein interaction landscape of breast cancer.

DOCK4 AKT3 DST PIK3CA UGGT1 MACF1 MYO1B MCM10 NOP2 ARAF

2.78e-06634831034591612
Pubmed

Knockdown of AKT3 (PKBγ) and PI3KCA suppresses cell viability and proliferation and induces the apoptosis of glioblastoma multiforme T98G cells.

AKT3 PIK3CA

5.63e-06283224967401
Pubmed

Combination Therapy with AKT3 and PI3KCA siRNA Enhances the Antitumor Effect of Temozolomide and Carmustine in T98G Glioblastoma Multiforme Cells.

AKT3 PIK3CA

5.63e-06283226902608
Pubmed

Acf7 (MACF) is an actin and microtubule linker protein whose expression predominates in neural, muscle, and lung development.

DST MACF1

5.63e-06283211002341
Pubmed

GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.

GHSR DRD2

5.63e-06283229632174
Pubmed

PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia.

AKT3 PIK3CA

5.63e-06283225722288
Pubmed

Genomic, Transcriptomic, Epigenetic, and Immune Profiling of Mucinous Breast Cancer.

PIK3CA MUC2

5.63e-06283230789657
Pubmed

Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion.

ESCO2 ESCO1

5.63e-06283215958495
Pubmed

Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells.

CLCN5 LRP2

5.63e-06283217369355
Pubmed

DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation.

DOCK4 MUC2

5.63e-06283233559155
Pubmed

Esco1 and Esco2 regulate distinct cohesin functions during cell cycle progression.

ESCO2 ESCO1

5.63e-06283228847955
Pubmed

Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers.

GHSR DRD2

5.63e-06283233264473
Pubmed

Bradykinin B2 and dopamine D2 receptors form a functional dimer.

DRD2 BDKRB2

5.63e-06283228757212
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

DST DIS3L UGGT1 AOAH TMEM266 UGT8 RRM1 TTF1 MELK PLEKHO1 SBNO2 DOP1B ZNF3

1.15e-051293831315342556
Pubmed

Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.

DST DNAH17 MACF1

1.45e-052083321689717
Pubmed

Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway.

PIK3CA MUC2

1.69e-05383220718712
Pubmed

Expression of the mouse Macf2 gene during inner ear development.

DST MACF1

1.69e-05383212399109
Pubmed

Non-redundant roles in sister chromatid cohesion of the DNA helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2.

ESCO2 ESCO1

1.69e-05383231935221
Pubmed

Mutational analysis of PHEX, FGF23 and CLCN5 in patients with hypophosphataemic rickets.

PHEX CLCN5

1.69e-05383228383812
Pubmed

Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis.

AKT3 PIK3CA

1.69e-05383225122428
Pubmed

Possible involvement of type 1 inositol 1,4,5-trisphosphate receptors up-regulated by dopamine D1 and D2 receptors in mouse nucleus accumbens neurons in the development of methamphetamine-induced place preference.

DRD2 ITPR1

1.69e-05383223000618
Pubmed

Short-term functional adaptation of aquaporin-1 surface expression in the proximal tubule, a component of glomerulotubular balance.

CLCN5 LRP2

1.69e-05383225270072
Pubmed

Knockdown of the AKT3 (PKBγ), PI3KCA, and VEGFR2 genes by RNA interference suppresses glioblastoma multiforme T98G cells invasiveness in vitro.

AKT3 PIK3CA

1.69e-05383225501707
Pubmed

Alternative catalytic residues in the active site of Esco acetyltransferases.

ESCO2 ESCO1

1.69e-05383232555289
Pubmed

Mutational analysis of PHEX, FGF23, DMP1, SLC34A3 and CLCN5 in patients with hypophosphatemic rickets.

PHEX CLCN5

1.69e-05383222695891
Pubmed

Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules.

CLCN5 LRP2

1.69e-05383212815097
Pubmed

Regulation of type 1 IP₃ receptor expression by dopamine D2-like receptors via AP-1 and NFATc4 activation.

DRD2 ITPR1

1.69e-05383223597509
Pubmed

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly.

AKT3 PIK3CA

1.69e-05383222729223
Pubmed

De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes.

AKT3 PIK3CA

1.69e-05383222729224
Pubmed

Regulation of type 1 inositol 1,4,5-triphosphate receptor by dopamine receptors in cocaine-induced place conditioning.

DRD2 ITPR1

1.69e-05383222033896
Pubmed

Human parietal epithelial cells (PECs) and proteinuria in lupus nephritis: a role for ClC-5, megalin, and cubilin?

CLCN5 LRP2

1.69e-05383237594671
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

DOCK4 MCTP1 LRP2 IL6ST

2.59e-057183433541421
Pubmed

A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunction.

CLCN5 LRP2

3.37e-05483218322545
Pubmed

Expressed Gene Fusions as Frequent Drivers of Poor Outcomes in Hormone Receptor-Positive Breast Cancer.

AKT3 PIK3CA

3.37e-05483229242214
Pubmed

Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries.

DNAH9 DNAH11

3.37e-05483236140829
Pubmed

Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate.

CLCN5 LRP2

3.37e-05483224950692
Pubmed

Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP).

RTN4 RTN4IP1

3.37e-05483212067236
Pubmed

Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins.

DST MACF1

3.37e-0548328954775
Pubmed

Ubiquitin-specific peptidase 8 (USP8) regulates endosomal trafficking of the epithelial Na+ channel.

USP8 SCNN1B

3.37e-05483223297398
Pubmed

Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.

AKT3 PLEKHO1

3.37e-05483217942896
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DOCK4 USP8 DST DTL MAP3K10 MACF1 MLXIP MELK ARAF DOP1B

3.91e-05861831036931259
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

KLHL29 TRANK1 PIEZO1 RNF213 MLXIP MUC2 ITPR1 DNAH11

5.32e-0555283810737800
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

KLHL29 DOCK4 USP8 DOCK9 MACF1 MLXIP DOP1B

5.52e-0540783712693553
Pubmed

USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-β receptor TβRII.

TGFBR2 USP8

5.60e-05583235811497
Pubmed

Expression of matrix metalloproteinase-13 is controlled by IL-13 via PI3K/Akt3 and PKC-δ in normal human dermal fibroblasts.

AKT3 PIK3CA

5.60e-05583221191416
Pubmed

DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes.

DNAH9 DNAH11

5.60e-05583226909801
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

USP8 DST NUDT5 DOCK9 RTN4 MACF1 MYO1B IL6ST

6.26e-0556583825468996
Pubmed

Cohesin acetylation speeds the replication fork.

ESCO2 ESCO1

8.39e-05683219907496
Pubmed

Epithelial sodium channel regulated by differential composition of a signaling complex.

PIK3CA SCNN1B

8.39e-05683219380724
Pubmed

TLR4 ligand/H₂O₂ enhances TGF-β1 signaling to induce metastatic potential of non-invasive breast cancer cells by activating non-Smad pathways.

TGFBR2 PIK3CA

8.39e-05683223734265
Pubmed

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.

DNAH9 DNAH11

8.39e-05683233347437
Pubmed

The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas.

AKT3 PIK3CA

8.39e-05683222107784
Pubmed

Mutational and immunohistochemical study of the PI3K/Akt pathway in papillary thyroid carcinoma in Greece.

AKT3 PIK3CA

8.39e-05683220186503
Pubmed

Lysine acetylation targets protein complexes and co-regulates major cellular functions.

USP8 RNF213 ARAF

1.04e-043883319608861
Pubmed

New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo.

XPA MELK

1.17e-0478329136115
Pubmed

CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.

DNAH17 DNAH11

1.17e-04783233139725
Pubmed

Epidemiology of the antibiotic resistance of Helicobacter pylori in Canada.

ESCO2 ESCO1

1.17e-04783211111111
Pubmed

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

ANO2 ALDH1L2 NPSR1 NRG3 IL6ST

1.18e-0419983523382691
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

WDR75 PIEZO1 PRC1 TTF1 NOP2

1.52e-0421083516565220
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

RBM25 DST WDR75 UGGT1 MACF1 MYO1B TTF1 NOP2

1.69e-0465383822586326
Pubmed

Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.

ESCO2 TRANK1 RNF213 NOP2

1.76e-0411683421282530
Pubmed

Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein.

PIK3CA ARAF

2.00e-04983211969417
Pubmed

Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat.

AKT3 PIK3CA

2.00e-04983221765914
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

DST WDR75 ALDH1L2 RTN4 DTL LRP2 RNF213 RTN4IP1 DBT NOP2 ARAF ITPR1

2.20e-041496831232877691
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

DST LMLN TTF1 DNAH9

2.21e-0412383426912792
Pubmed

Sororin mediates sister chromatid cohesion by antagonizing Wapl.

ESCO2 ESCO1

2.50e-041083221111234
Pubmed

Cohesion establishment factor, Eco1 represses transcription via association with histone demethylase, LSD1.

ESCO2 ESCO1

2.50e-041083220331966
Pubmed

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

AKT3 PIK3CA

3.05e-041183218449193
Pubmed

Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta.

AKT3 PIK3CA

3.05e-041183223077641
Pubmed

The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.

DST MACF1

3.05e-041183216815997
Pubmed

HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway.

AKT3 PIK3CA

3.05e-041183225104021
Pubmed

Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development.

AKT3 PIK3CA

3.66e-041283220665729
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

FAT4 DST LRP2 RNF213 TAS2R31 NIPAL3 ESCO1 DOP1B

3.78e-0473683829676528
Pubmed

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.

RTN4 RNF213 MYO1B NOP2

4.02e-0414483435681168
Pubmed

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

WDR75 UGGT1 RNF213 NOP2 SBNO2

4.20e-0426283536880596
Pubmed

Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.

AKT3 PIK3CA

4.31e-04138329394803
Pubmed

Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos.

TGFBR2 AKT3

5.03e-041483212773577
Pubmed

Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.

AKT3 PIK3CA

5.03e-041483217157319
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH17 DNAH11

5.03e-04148329373155
Pubmed

TGF-β specifies TFH versus TH17 cell fates in murine CD4+ T cells through c-Maf.

TGFBR2 IL6ST

5.03e-041483238427718
Pubmed

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

DOCK4 DOCK9

5.03e-041483212432077
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

FAT4 POMGNT2 PIEZO1 RTN4 UGGT1 UGT8 RNF213 RRM1 IL6ST ITPR1

5.75e-041201831035696571
Pubmed

Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.

DOCK4 PIK3CA UGGT1

5.87e-046883325754235
Pubmed

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.

DOCK4 GGA2 MACF1 ARAF

5.98e-0416083431678930
Pubmed

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

DST CSTL1 UGGT1 C5 ESCO1

6.05e-0428483529459677
Pubmed

Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation.

AKT3 PIK3CA

6.61e-041683221029719
Pubmed

Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders.

AKT3 PIK3CA

6.61e-041683220818790
Pubmed

HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.

AKT3 PIK3CA

6.61e-041683216524887
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

KLHL29 ANO2 AOAH MYO1B XPA NRG3 SDK1 ITPR1

7.32e-0481483823251661
Pubmed

Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.

MACF1 ITPR1

7.48e-041783220395553
Pubmed

Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes.

AKT3 PIK3CA

7.48e-041783223251686
Pubmed

Identification of novel human WW domain-containing proteins by cloning of ligand targets.

CLCN5 SCNN1B

8.40e-04188329169421
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

ESCO2 DST NUDT5 MCM10 DBT PRC1 NOP2

8.97e-0464583725281560
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

DOCK4 GGA2 NUDT5 DIS3L LRP2 MLXIP DBT ARAF

9.89e-0485383828718761
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

RBM25 DST WDR75 UGGT1 MACF1 PRC1 NOP2

1.03e-0366083732780723
Pubmed

Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.

MCM10 MUC2

1.04e-032083226023099
Pubmed

Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.

FBXW2 RRM1

1.04e-032083222632967
GeneFamilyDyneins, axonemal

DNAH17 DNAH9 DNAH11

1.96e-0517573536
GeneFamilyEF-hand domain containing|Plakins

DST MACF1

2.70e-048572939
CoexpressionLAKE_ADULT_KIDNEY_C22_ENDOTHELIAL_CELLS_GLOMERULAR_CAPILLARIES

DOCK4 TGFBR2 AKT3 MACF1 NRG3 IL6ST

4.96e-06137836M39241
CoexpressionSTEIN_ESRRA_TARGETS_RESPONSIVE_TO_ESTROGEN_DN

ZWILCH DTL MCM10 RRM1

8.66e-0641834M19002
CoexpressionMORI_LARGE_PRE_BII_LYMPHOCYTE_UP

DTL PRC1 RRM1 MELK ANAPC5

8.98e-0688835M19287
CoexpressionLAKE_ADULT_KIDNEY_C24_ENDOTHELIAL_CELLS_AEA_AND_DVR

DOCK4 AKT3 DST DOCK9 MACF1 IL6ST

9.00e-06152836M39243
CoexpressionGRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_DN

DTL MCM10 PRC1 RRM1 MELK

9.50e-0689835M5198
CoexpressionMORI_IMMATURE_B_LYMPHOCYTE_DN

DTL MCM10 PRC1 RRM1 MELK

1.06e-0591835M18917
CoexpressionMORI_IMMATURE_B_LYMPHOCYTE_DN

DTL MCM10 PRC1 RRM1 MELK

1.18e-0593835MM1138
CoexpressionMORI_LARGE_PRE_BII_LYMPHOCYTE_UP

DTL PRC1 RRM1 MELK ANAPC5

1.18e-0593835MM1137
CoexpressionLAKE_ADULT_KIDNEY_C26_MESANGIAL_CELLS

DOCK4 AKT3 DST NRG3 IL6ST ITPR1

2.14e-05177836M39245
CoexpressionGEORGES_TARGETS_OF_MIR192_AND_MIR215

ESCO2 DST TENT4A DIS3L LMLN DTL UGT8 MACF1 FBXW2 MCM10 DBT IL6ST

2.36e-058928312M18120
CoexpressionHOSHIDA_LIVER_CANCER_SURVIVAL_DN

DOCK4 DST XPA C5 RRM1

3.03e-05113835M5451
CoexpressionFLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_DN

ESCO2 DTL UGT8 C5 PRC1 MELK

3.18e-05190836M761
CoexpressionTRAVAGLINI_LUNG_ALVEOLAR_EPITHELIAL_TYPE_1_CELL

DOCK4 TGFBR2 DST PIEZO1 SCNN1B RNF213 MYO1B PLEKHO1

3.40e-05391838M41659
CoexpressionFUJII_YBX1_TARGETS_DN

DTL MCM10 RRM1 MELK ITPR1 POLR3F

3.58e-05194836M14340
CoexpressionGSE5589_WT_VS_IL6_KO_LPS_STIM_MACROPHAGE_45MIN_UP

TGFBR2 GGA2 MCTP1 PIK3CA ESCO1 DOP1B

4.12e-05199836M6638
CoexpressionLAZARO_GENETIC_MOUSE_MODEL_HIGH_GRADE_LARGE_CELL_NEUROENDOCRINE_LUNG_CARCINOMA_UP

ESCO2 ZWILCH CLCN5 DTL MCM10 PRC1 RRM1 MELK

4.13e-05402838MM454
CoexpressionGSE30962_ACUTE_VS_CHRONIC_LCMV_SECONDARY_INF_CD8_TCELL_DN

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1

4.24e-05200836M5052
CoexpressionGSE15750_DAY6_VS_DAY10_TRAF6KO_EFF_CD8_TCELL_UP

ESCO2 ZWILCH DTL MCM10 RRM1 MELK

4.24e-05200836M3580
CoexpressionGSE22313_HEALTHY_VS_SLE_MOUSE_CD4_TCELL_DN

AOAH DTL MCM10 PRC1 RRM1 MELK

4.24e-05200836M8584
CoexpressionGSE10239_NAIVE_VS_DAY4.5_EFF_CD8_TCELL_DN

ZWILCH NUDT5 DTL PRC1 RRM1 MELK

4.24e-05200836M3072
CoexpressionGEORGES_CELL_CYCLE_MIR192_TARGETS

TENT4A DTL MACF1 MCM10

4.53e-0562834M11038
CoexpressionSENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP

ESCO2 DOCK4 AKT3 DTL PRC1 RRM1 MELK

5.26e-05305837M19875
CoexpressionVAN_DEN_BIGGELAAR_PBMC_PREVNAR_9MO_INFANT_STIMULATED_VS_UNSTIMULATED_9MO_UP

ESCO2 DTL MCM10 PRC1 MELK

5.29e-05127835M40952
CoexpressionGSE11884_WT_VS_FURIN_KO_NAIVE_CD4_TCELL_DN

DST CSTL1 MLXIP BDKRB2 SBNO2

5.50e-05128835M410
CoexpressionLAKE_ADULT_KIDNEY_C2_PODOCYTES

KLHL29 DOCK4 AKT3 DST MACF1 MYO1B

5.86e-05212836M39221
CoexpressionDUTERTRE_ESTRADIOL_RESPONSE_24HR_UP

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

7.53e-05323837M2156
CoexpressionSENESE_HDAC1_TARGETS_UP

ESCO2 DOCK4 TGFBR2 AKT3 CARNMT1 ANAPC5 IL6ST ITPR1

9.22e-05451838M14973
CoexpressionMORI_PRE_BI_LYMPHOCYTE_UP

DTL PRC1 RRM1 MELK

1.29e-0481834M1395
CoexpressionSTEIN_ESR1_TARGETS

ZWILCH DTL MCM10 RRM1

1.42e-0483834M9678
CoexpressionKOBAYASHI_EGFR_SIGNALING_24HR_DN

ZWILCH DTL MCM10 PRC1 RRM1 MELK

1.55e-04253836M16010
CoexpressionLAKE_ADULT_KIDNEY_C29_UNKNOWN_NOVEL_PT_CFH_POS_SUBPOPULATION_S2

AKT3 DST MACF1 NRG3

1.63e-0486834M39248
CoexpressionMORI_PRE_BI_LYMPHOCYTE_UP

DTL PRC1 RRM1 MELK

1.70e-0487834MM1136
CoexpressionSENESE_HDAC3_TARGETS_UP

DOCK4 TGFBR2 AKT3 GGA2 DST CLCN5 MYO1B IL6ST

1.75e-04495838M8451
CoexpressionGCNP_SHH_UP_LATE.V1_UP

CLCN5 PIK3CA MCM10 PRC1 RRM1

2.79e-04181835M2641
CoexpressionBURTON_ADIPOGENESIS_3

DTL MCM10 PRC1 RRM1

3.02e-04101834M1577
CoexpressionGSE14415_TCONV_VS_FOXP3_KO_INDUCED_TREG_DN

DTL PRC1 RRM1 NOP2 ANAPC5

3.09e-04185835M2965
CoexpressionGSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_12H_UP

ESCO2 PRC1 RRM1 PLEKHO1 ANAPC5

3.24e-04187835M2984
CoexpressionBURTON_ADIPOGENESIS_3

DTL MCM10 PRC1 RRM1

3.38e-04104834MM1180
CoexpressionZHAN_MULTIPLE_MYELOMA_MF_DN

TRANK1 DOCK9 NRG3

3.45e-0443833M513
CoexpressionBASAKI_YBX1_TARGETS_UP

ZWILCH NUDT5 DTL MCM10 PRC1 MELK

3.46e-04294836M14985
CoexpressionCUI_TCF21_TARGETS_2_DN

DOCK4 TGFBR2 DST PIK3CA MACF1 MYO1B DBT ESCO1 ARAF IL6ST

3.63e-048548310M1533
CoexpressionZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_DN

GGA2 DTL RTN4IP1 MCM10

3.63e-04106834M9160
CoexpressionBURTON_ADIPOGENESIS_PEAK_AT_24HR

PRC1 RRM1 MELK

3.69e-0444833M1591
CoexpressionWEST_ADRENOCORTICAL_TUMOR_UP

ZWILCH RTN4 DTL PRC1 MELK MVD

3.72e-04298836M1918
CoexpressionGSE1791_CTRL_VS_NEUROMEDINU_IN_T_CELL_LINE_12H_DN

ESCO2 FAT4 DTL PLEKHO1 MVD

3.75e-04193835M6169
CoexpressionGSE21546_ELK1_KO_VS_SAP1A_KO_AND_ELK1_KO_DP_THYMOCYTES_DN

GGA2 DIS3L MCM10 RRM1 TTF1

4.12e-04197835M7546
CoexpressionGSE21927_SPLEEN_VS_4T1_TUMOR_MONOCYTE_BALBC_DN

TMEM266 CARNMT1 NOP2 ARAF SBNO2

4.12e-04197835M7560
CoexpressionGSE29949_MICROGLIA_BRAIN_VS_CD8_NEG_DC_SPLEEN_DN

CLCN5 AOAH MAP3K10 MYO1B DNAH9

4.21e-04198835M8400
CoexpressionGSE3982_CENT_MEMORY_CD4_TCELL_VS_TH2_UP

TRANK1 UGT8 MACF1 MUC2 IL6ST

4.21e-04198835M5591
CoexpressionZHAN_MULTIPLE_MYELOMA_PR_UP

ZWILCH MCM10 PRC1

4.21e-0446833M4888
CoexpressionGSE41867_NAIVE_VS_DAY8_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN

AKT3 MCTP1 PIK3CA FBXW2 XPA

4.31e-04199835M9498
CoexpressionGSE36392_TYPE_2_MYELOID_VS_EOSINOPHIL_IL25_TREATED_LUNG_UP

PIEZO1 DTL ANAPC5 IL6ST ZNF3

4.31e-04199835M5270
CoexpressionGSE25123_CTRL_VS_ROSIGLITAZONE_STIM_PPARG_KO_MACROPHAGE_DN

SCNN1B C5 SDK1 ESCO1 IL6ST

4.31e-04199835M7998
CoexpressionGSE7548_NAIVE_VS_DAY28_PCC_IMMUNIZATION_CD4_TCELL_UP

DOCK4 AKT3 PIK3CA LRP2 RRM1

4.31e-04199835M6839
CoexpressionGSE20727_DNFB_ALLERGEN_VS_ROS_INH_AND_DNFB_ALLERGEN_TREATED_DC_DN

ESCO2 DTL CARNMT1 MCM10 MELK

4.31e-04199835M9256
CoexpressionGSE2770_IL12_AND_TGFB_VS_IL4_TREATED_ACT_CD4_TCELL_6H_DN

CLCN5 C5 IL6ST MVD ACOT12

4.31e-04199835M6066
CoexpressionLEE_EARLY_T_LYMPHOCYTE_UP

DTL MCM10 PRC1 MELK

4.33e-04111834M7357
CoexpressionGSE2585_AIRE_KO_VS_WT_CD80_HIGH_MTEC_DN

TGFBR2 DIS3L LMLN NIPAL3 IL6ST

4.41e-04200835M6273
CoexpressionGSE25088_IL4_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_DAY10_UP

ESCO2 AKT3 CLCN5 RTN4IP1 MELK

4.41e-04200835M7981
CoexpressionGSE15750_DAY6_VS_DAY10_EFF_CD8_TCELL_UP

ESCO2 MCM10 PRC1 RRM1 MELK

4.41e-04200835M3577
CoexpressionHALLMARK_COMPLEMENT

PHEX DOCK4 USP8 PIK3CA DOCK9

4.41e-04200835M5921
CoexpressionGSE14350_TREG_VS_TEFF_DN

DRD2 POMGNT2 ALDH1L2 UGT8 RRM1

4.41e-04200835M3418
CoexpressionGSE29164_CD8_TCELL_VS_CD8_TCELL_AND_IL12_TREATED_MELANOMA_DAY3_UP

MCTP1 TENT4A PIEZO1 DBT POLR3F

4.41e-04200835M8491
CoexpressionGSE39110_DAY3_VS_DAY6_POST_IMMUNIZATION_CD8_TCELL_DN

ESCO2 DTL MCM10 MELK PLEKHO1

4.41e-04200835M9277
CoexpressionGSE21670_UNTREATED_VS_TGFB_TREATED_CD4_TCELL_UP

DRD2 DNAH17 LRP2 SDK1 ACOT12

4.41e-04200835M7471
CoexpressionGSE40666_WT_VS_STAT1_KO_CD8_TCELL_WITH_IFNA_STIM_90MIN_DN

ZWILCH RNF213 MCM10 MELK PLEKHO1

4.41e-04200835M9215
CoexpressionGOLDRATH_EFF_VS_MEMORY_CD8_TCELL_UP

CLCN5 DTL MCM10 PRC1 RRM1

4.41e-04200835M3041
CoexpressionGSE10239_MEMORY_VS_DAY4.5_EFF_CD8_TCELL_DN

ZWILCH NUDT5 MCM10 RRM1 ITPR1

4.41e-04200835M3074
CoexpressionHEVNER_CORTEX_RADIAL_GLIA_PROGENITORS

ZWILCH NUDT5 DTL LRP2 MCM10 PRC1 MELK

4.45e-04432837MM419
CoexpressionDODD_NASOPHARYNGEAL_CARCINOMA_UP

ESCO2 DOCK4 ZWILCH AKT3 WDR75 DTL RNF213 MCM10 PRC1 RRM1 NOP2 MELK ANAPC5

4.60e-0414078313M14427
CoexpressionBURTON_ADIPOGENESIS_PEAK_AT_24HR

PRC1 RRM1 MELK

4.78e-0448833MM1181
CoexpressionHE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL

ESCO2 ZWILCH PIK3CA PIEZO1 UGGT1 DTL UGT8 PRC1 MELK ARAF POLR3F

4.82e-0410548311M45798
CoexpressionCUI_TCF21_TARGETS_2_DN

DOCK4 TGFBR2 DST PIK3CA MACF1 MYO1B DBT ESCO1 ARAF IL6ST

4.92e-048888310MM1018
CoexpressionGOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK PLEKHO1

4.93e-04578838M2368
CoexpressionVANTVEER_BREAST_CANCER_POOR_PROGNOSIS

DTL PRC1 MELK

5.08e-0449833M14693
CoexpressionSANSOM_APC_TARGETS

DIS3L PIEZO1 DTL MYO1B CARNMT1

5.39e-04209835M1755
CoexpressionMEBARKI_HCC_PROGENITOR_FZD8CRD_UP

ESCO2 ZWILCH MCM10 PRC1 RRM1 NIPAL3 MELK PLEKHO1

5.51e-04588838M38992
CoexpressionLEE_BMP2_TARGETS_DN

KLHL29 ZWILCH NUDT5 WDR75 DTL CARNMT1 MCM10 RRM1 NOP2 MELK

5.66e-049048310M2325
CoexpressionGOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK PLEKHO1

6.09e-04597838MM1309
CoexpressionLEE_BMP2_TARGETS_DN

KLHL29 ZWILCH NUDT5 WDR75 DTL CARNMT1 MCM10 RRM1 NOP2 MELK

6.59e-049228310MM1068
CoexpressionLAKE_ADULT_KIDNEY_C23_ENDOTHELIAL_CELLS_AVR

DOCK4 TGFBR2 AKT3 IL6ST

6.98e-04126834M39242
CoexpressionKINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP

ZWILCH GGA2 NUDT5 DTL RTN4IP1 CARNMT1 MCM10 PRC1 RRM1 TTF1 MELK POLR3F

7.31e-0412908312M80
CoexpressionBLANCO_MELO_COVID19_SARS_COV_2_INFECTION_CALU3_CELLS_UP

TRANK1 ALDH1L2 DNAH17 LRP2 RNF213 BDKRB2

7.32e-04339836M34012
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_7DY_NEGATIVE

TGFBR2 AKT3 RBM25 WDR75 DOCK9 IL6ST SBNO2

7.70e-04474837M40991
CoexpressionDESCARTES_FETAL_THYMUS_VASCULAR_ENDOTHELIAL_CELLS

ANO2 DOCK9 MYO1B NRG3

8.07e-04131834M40316
CoexpressionAtlasB cells, B.GC.Sp, CD19+ IgM+ IgD- GL7+ PNA+, Spleen, avg-3

ESCO2 ZWILCH GGA2 DTL RTN4IP1 MCM10 PRC1 RRM1 MELK

1.17e-05380799GSM538207_500
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#5_top-relative-expression-ranked_500

ESCO2 DOCK4 RNF213 SNX16 ESCO1

2.27e-0591795gudmap_developingGonad_e12.5_ovary_k5_500
CoexpressionAtlasDevelopingGonad_P2_ovary_emap-30224_k-means-cluster#4_top-relative-expression-ranked_1000

ESCO2 DOCK9 RNF213 CARNMT1 SNX16 ESCO1

3.87e-05168796gudmap_developingGonad_P2_ovary_1000_k4
CoexpressionAtlasdev gonad_e11.5_F_PrimGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_1000

ESCO2 ZWILCH WDR75 RTN4IP1 MCM10 PRC1 NOP2 MELK POLR3F

5.49e-05463799gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_k3_1000
CoexpressionAtlasB cells, proB.FrA.BM, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Bone marrow, avg-2

ESCO2 ZWILCH MCTP1 DTL MCM10 PRC1 RRM1 ITPR1

9.73e-05388798GSM538352_500
CoexpressionAtlasalpha beta T cells, NKT.44-NK1.1-.Th, aGC CD1d tet CD3e, Thymus, avg-2

ESCO2 ZWILCH DTL C5 MCM10 PRC1 RRM1 MELK

1.16e-04398798GSM538338_500
CoexpressionAtlasStem Cells, SC.MEP.BM, Lineage- Kit+ Sca1- CD34- FcgR-/low, Bone marrow, avg-2

ESCO2 ZWILCH NUDT5 DTL CARNMT1 MCM10 PRC1 RRM1

1.22e-04401798GSM791108_500
CoexpressionAtlasStem Cells, SC.MDP.BM, Sca1- Flt3+ MCSFR+ cKithi, Bone marrow, avg-3

ESCO2 ZWILCH MCTP1 DTL MCM10 PRC1 RRM1 MELK

1.24e-04402798GSM791105_500
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#3_top-relative-expression-ranked_1000

ESCO2 KLHL29 PHEX FAT4 PIK3CA DTL MCM10

1.47e-04307797gudmap_developingKidney_e15.5_Peripheral blastema_1000_k3
CoexpressionAtlasB cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-2

ESCO2 ZWILCH MCTP1 DTL MCM10 PRC1 RRM1 MELK

1.65e-04419798GSM538348_500
CoexpressionAtlasgamma delta T cells, Tgd.vg3+24alo.e17.Th, TCRd+ Vg3+ CD24-, Fetal Thymus, avg-3

ESCO2 ZWILCH AOAH DTL MCM10 PRC1 RRM1 MELK

1.65e-04419798GSM476664_500
CoexpressionAtlasdev gonad_e11.5_F_PrimGermCell_Oct_top-relative-expression-ranked_1000

ESCO2 ZWILCH WDR75 UGT8 RTN4IP1 CARNMT1 MCM10 PRC1 NOP2 MELK POLR3F

1.75e-047997911gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_1000
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#5_top-relative-expression-ranked_1000

DOCK4 DOCK9 RNF213 CARNMT1 SNX16 ESCO1

2.18e-04230796gudmap_developingGonad_e18.5_ovary_1000_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder detrusor (LCM)_emap-30376_k-means-cluster#2_top-relative-expression-ranked_500

ALDH1L2 FBXW2 NIPAL3 PLEKHO1 IL6ST

3.01e-04157795gudmap_developingLowerUrinaryTract_P2_bladder detrusor (LCM)_500_k2
CoexpressionAtlasdev gonad_e11.5_M_PrimGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_1000

ESCO2 ZWILCH WDR75 RTN4IP1 PRC1 MELK

4.02e-04258796gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_k2_1000
CoexpressionAtlasgamma delta T cells, Tgd.vg1+vd6-.Th, TCRd+ Vg1.1+, Thymus, avg-3

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

4.78e-04373797GSM605781_500
CoexpressionAtlasDevelopingKidney_e15.5_cortic collect duct_emap-28132_k-means-cluster#4_top-relative-expression-ranked_1000

AKT3 PIK3CA UGT8 FBXW2 IL6ST ITPR1 POLR3F

4.93e-04375797gudmap_developingKidney_e15.5_cortic collect duct_1000_k4
CoexpressionAtlasalpha beta T cells, T.DN4.Th, Lin-/lo CD25- CD44- CD28+, Thymus, avg-3

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

5.01e-04376797GSM791154_500
CoexpressionAtlasdev gonad_e13.5_F_DevVascOvary_Flk_k-means-cluster#2_top-relative-expression-ranked_1000

DOCK4 FAT4 DOCK9

5.13e-0442793gudmap_dev gonad_e13.5_F_gudmap_devVascOvary_Flk_k2_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_1000

KLHL29 PHEX SPTLC3 FAT4 AKT3 DST PIK3CA UGT8 FBXW2 IL6ST

5.52e-047697910gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000
CoexpressionAtlasDevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_1000

AKT3 PIK3CA SCNN1B LRP2 UGT8 FBXW2 IL6ST DOP1B ITPR1 POLR3F

5.80e-047747910gudmap_developingKidney_e15.5_cortic collect duct_1000
CoexpressionAtlasDevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#5_top-relative-expression-ranked_1000

ESCO2 DOCK4 SNX16 ESCO1

6.38e-04105794gudmap_developingGonad_e11.5_ovary + mesonephros_k5_1000
CoexpressionAtlasalpha beta T cells, NKT.44+NK1.1-.Th, aGC CD1d tet CD3 CD44, Thymus, avg-3

ESCO2 ZWILCH DTL C5 PRC1 RRM1 MELK

6.41e-04392797GSM538335_500
CoexpressionAtlasB cells, B.Pl.AA4-.BM, CD138+ AA4.1- CD43+, Bone marrow, avg-2

ESCO2 ZWILCH MCTP1 AOAH DTL PRC1 RRM1

6.61e-04394797GSM777030_500
CoexpressionAtlasdev gonad_e11.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000

DOCK4 FAT4 TRANK1 DST PIEZO1 DOCK9 RNF213 ESCO1 IL6ST ITPR1

6.86e-047917910gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_1000
CoexpressionAtlasalpha beta T cells, preT.DN3-4.Th, Lin-/lo CD25int CD44- CD28+, Thymus, avg-3

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

6.91e-04397797GSM791143_500
CoexpressionAtlasalpha beta T cells, T.DPbl.Th, 4+ 8+ TCR-/lo FSChi, Thymus, avg-3

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

7.01e-04398797GSM399397_500
CoexpressionAtlasdev gonad_e12.5_M_GermCellTestis_Oct_top-relative-expression-ranked_1000

ESCO2 ZWILCH WDR75 UGT8 RTN4IP1 MCM10 PRC1 NOP2 MELK POLR3F

7.13e-047957910gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_1000
CoexpressionAtlasB cells, proB.FrBC.FL, CD19+ IgM- CD43+ CD24+ AA4.1+ CD45R+, Fetal Liver, avg-3

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

7.22e-04400797GSM538358_500
CoexpressionAtlasStem Cells, SC.CDP.BM, Sca1- Flt3+ MCSFR+ cKitlo, Bone marrow, avg-3

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

7.33e-04401797GSM791114_500
CoexpressionAtlasB cells, proB.FrBC.BM, CD19+ IgM- CD43+ AA4.1+ CD45R+, Bone marrow, avg-2

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

7.33e-04401797GSM399450_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#1_top-relative-expression-ranked_100

SPTLC3 DST

7.36e-0411792gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_100_k1
CoexpressionAtlasalpha beta T cells, T.8Eff.Sp.OT1.d6.LisOva, CD8+ CD45.1+, Spleen, avg-3

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

7.44e-04402797GSM605898_500
CoexpressionAtlasB cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

8.23e-04409797GSM399452_500
CoexpressionAtlasdev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_1000

ESCO2 ZWILCH WDR75 UGT8 RNF213 RTN4IP1 MCM10 NOP2 MELK POLR3F

8.23e-048107910gudmap_dev gonad_e13.5_M_GermCell_Oct_1000
CoexpressionAtlasFetal Liver, SC.STSL.FL, IgM- CD24- CD117+ IL7R- CD150- CD48- AA4.1+ CD43+, Fetal Liver, avg-2

ESCO2 ZWILCH MCTP1 DTL MCM10 PRC1 RRM1

8.34e-04410797GSM791122_500
CoexpressionAtlasalpha beta T cells, T.8Eff.Sp.OT1.d5.VSVOva, CD8+ CD45.1+, Spleen, avg-3

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

8.34e-04410797GSM538387_500
CoexpressionAtlasStem Cells, SC.ST34F.BM, Lineage- cKit+ Sca-1+ flk2- CD34+, Bone marrow, avg-2

ESCO2 ZWILCH NUDT5 MCTP1 DTL PRC1 RRM1

8.46e-04411797GSM791112_500
CoexpressionAtlasalpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3

ZWILCH NUDT5 DTL MCM10 PRC1 RRM1 MELK

8.71e-04413797GSM791149_500
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#5_top-relative-expression-ranked_200

KLHL29 PHEX

8.80e-0412792gudmap_developingKidney_e15.5_Peripheral blastema_200_k5
CoexpressionAtlasgamma delta T cells, Tgd.vg2+24ahi.e17.Th, TCRd+ Vg2+ CD24+, Fetal Thymus, avg-3

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

8.83e-04414797GSM476660_500
CoexpressionAtlasdev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_1000

ESCO2 ZWILCH WDR75 UGT8 RNF213 RTN4IP1 CARNMT1 MCM10 PRC1 MELK

9.21e-048227910gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_1000
CoexpressionAtlasalpha beta T cells, T.ISP.Th, 4- 8+ TCR-/lo 24hi, Thymus, avg-3

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.21e-04417797GSM399403_500
CoexpressionAtlasB cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Fetal Liver, avg-1

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.34e-04418797GSM538350_500
CoexpressionAtlasDevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#5_top-relative-expression-ranked_1000

AKT3 PIK3CA FBXW2 ITPR1 POLR3F

9.66e-04203795gudmap_developingKidney_e15.5_Ureteral Smooth Musc_1000_k5
CoexpressionAtlasgamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.87e-04422797GSM476658_500
CoexpressionAtlasB cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Fetal Liver, avg-1

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.87e-04422797GSM538357_500
CoexpressionAtlasB cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R+ CD, Fetal Liver, avg-2

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.87e-04422797GSM538355_500
CoexpressionAtlasFetal Liver, SC.LTSL.FL, IgM- CD24- CD117+ IL7R- CD150+ CD48- AA4.1+ CD43+, Fetal Liver, avg-3

ESCO2 ZWILCH MCTP1 DTL MCM10 PRC1 RRM1

1.00e-03423797GSM791126_500
CoexpressionAtlasB cells, MLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-3

ZWILCH MCTP1 DTL MCM10 PRC1 RRM1 MELK

1.03e-03425797GSM791131_500
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#1_top-relative-expression-ranked_1000

ESCO2 UGT8 SNX16 ESCO1 ARAF

1.12e-03210795gudmap_developingGonad_e14.5_ ovary_1000_k1
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FAT4 DST MCTP1 DOCK9 DTL RNF213 MACF1 PLEKHO1

3.93e-09200838dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell343B-Myeloid-Dendritic-cDC_proliferating_1|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 ZWILCH NUDT5 DTL MCM10 PRC1 RRM1 MELK

3.93e-092008385f2fbd789cc16af411a01c3199583888b260ae91
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 DTL MCM10 PRC1 RRM1 MELK BDKRB2

3.04e-08169837a949f547b53126a208819bade74a1ac9b2a36ea7
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 DTL MCM10 PRC1 RRM1 MELK BDKRB2

3.04e-08169837195d5cd60d646ac6d40a3321b2f739917e7aef14
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 FAT4 TRANK1 LRP2 DNAH9 SDK1 DNAH11

5.45e-081848372cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 FAT4 TRANK1 LRP2 DNAH9 SDK1 DNAH11

5.45e-08184837ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 FAT4 TRANK1 LRP2 DNAH9 SDK1 DNAH11

5.45e-081848372b19a8c5f823e00812908b23e66bb4e563278aff
ToppCelldroplet-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

6.31e-081888370ec2a1b0505501ba18f10a5fce68c306a6292419
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

7.04e-0819183750854384fdaa0efa2e3227659d544ed09ac102f2
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic-lymphocyte-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ESCO2 DTL SCNN1B MCM10 PRC1 RRM1 MELK

7.04e-0819183756b45259dfc38bd5ea43b0e3adf47e7e2c043a5d
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT4 AKT3 DST MCTP1 DOCK9 DTL MACF1

7.83e-081948370b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCelldroplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

8.11e-08195837c1435e61e4f0cf457f26ae436936048932ceb0db
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

8.39e-081968379591a6a3477ed6a1e2e016f7542e38603d8b16cb
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

8.39e-081968371d2e0b328eb822db7521b5f5724d4bd17c0bad5f
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

8.69e-081978374b13335a43b9d6abc8e542e72440da7feb82fbe6
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic-lymphocyte-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

8.69e-0819783721861d8b389fafbdb7c3499684c9b6deee3dbd5e
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

8.69e-081978378b616cde333bdbc0c591035ad9e4949155866245
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic-lymphocyte|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

8.69e-08197837ffb004c37cdd26cb7cdcd80f769a2eded65416dc
ToppCellCOVID-19_Severe-T/NK_proliferative|World / disease group, cell group and cell class

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

8.99e-0819883748045689d0969ff0a14eee7086b8e19b0d6b6065
ToppCell343B-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

8.99e-08198837281fc2536cdc4c717b30de156e563c0e4baba99d
ToppCellBiopsy_Control_(H.)-Epithelial-Proliferating_Epithelial_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.31e-081998374fcf5bec207e4384fd73c5e8801a7e414e3ee7b0
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.31e-0819983788d130e2451e61afb710edf552e6b346b9fcfb2b
ToppCellCOVID-19_Severe-T/NK_proliferative|COVID-19_Severe / disease group, cell group and cell class

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.31e-08199837af78837f3a7641a5bd98765eef9cb4f86034048c
ToppCellsevere-Lymphocytic-Prol._cells|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.31e-08199837b24315952b6ac6c8d2d3a7bd949a5b5392624d4e
ToppCelldistal-2-Hematologic-Proliferating_Macrophage|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.63e-082008370cd3b01fb7f579e5abf000adb8ec8adc7cd779c4
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MCTP1 DOCK9 RNF213 MACF1 MYO1B PLEKHO1 BDKRB2

9.63e-082008372d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCellBiopsy_Control_(H.)-Immune-Proliferating_Macrophages|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.63e-08200837ce9fad55f779afd3d6c5a9c5a15e2d9f548b7c7e
ToppCellNS-critical-LOC-Lymphoid-Treg|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.63e-08200837d51e5c8c154b073caaf0cc09a3a3c0aafd57e44b
ToppCellSepsis-ICU-NoSEP-Lymphocyte-T/NK-T/NK_proliferative|ICU-NoSEP / Disease, condition lineage and cell class

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.63e-08200837f70cc9198339eab7fbc68f5d9b75dfb28c9afc89
ToppCell356C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.63e-082008372afbb5b5742b956993796621fea7e0c9888754a1
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.63e-0820083743571c9284d4e41402a2d1eefc1efe2ce8476d4a
ToppCell356C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.63e-082008374462ebd5d4632788f10a93fadd2babae701c754f
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.63e-0820083738665128b54f4a81b53c961427aed67bf4e2510b
ToppCellICU-NoSEP-Lymphocyte-T_NK-T_NK_proliferative|ICU-NoSEP / Disease, Lineage and Cell Type

ESCO2 ZWILCH DTL MCM10 PRC1 RRM1 MELK

9.63e-08200837d86119766b9c4f1570cd8045313345f9be46d431
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

RBM25 TENT4A DOCK9 RNF213 MACF1 IL6ST

4.78e-071568361545169694f686d28648a68b552c2ae606599d66
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ESCO2 ZWILCH DTL MCM10 PRC1 MELK

5.75e-071618360dd1401b4c990d49fccb702a9f9867590a58e203
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1-Mitotic.MkI67_(Mitotic.MkI67)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ESCO2 ZWILCH DTL MCM10 PRC1 MELK

5.75e-07161836b6a31c033edc74f23a20aab1f18e80cc83ffee4c
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P5|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ESCO2 ZWILCH DTL MCM10 PRC1 MELK

5.75e-07161836efb811dda4d73107983a5f68302bdcf4f408d5b4
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1-Mitotic.MkI67_(Mitotic.MkI67)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ESCO2 ZWILCH DTL MCM10 PRC1 MELK

5.75e-0716183628d5dbd20c9f8e0069f172d552997a044790e1a7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 DTL SCNN1B MCM10 RRM1 MELK

7.12e-07167836108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCelldroplet-Lung-immune-endo-depleted-3m-Lymphocytic-Proliferating_NK|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 ZWILCH DTL PRC1 RRM1 MELK

8.18e-071718361eebd7138c3b20ddc1104f21615f9df0e776bbe6
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 ZWILCH DTL PRC1 RRM1 ANAPC5

8.46e-071728362b6cd84c946b1e800caba452ae70145ea285fec1
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 ZWILCH DTL PRC1 RRM1 MELK

9.05e-07174836c988471207ba06195bc3e41056435e8c31c20bbe
ToppCell3'_v3-Lung-Lymphocytic_T_CD4/8-lo-Cycling_T|Lung / Manually curated celltypes from each tissue

ESCO2 DTL MCM10 PRC1 RRM1 MELK

9.67e-07176836a40dfd8c4ba16757ff929b2f03a0628acf334de4
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 ZWILCH RTN4IP1 PRC1 NIPAL3 MELK

9.67e-071768368385435074cc5235b7af7424974f609388fc2cff
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.00e-06177836f925a15d2162d166a5b60edac3517c6b2d6cfbea
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.10e-06180836f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4/8-lo-Cycling_T|bone_marrow / Manually curated celltypes from each tissue

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.21e-06183836a48a6313f2f144586951cece97ec31f6d72361df
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P5|Striatum / BrainAtlas - Mouse McCarroll V32

ESCO2 ZWILCH DTL MCM10 PRC1 MELK

1.21e-06183836f20b0d71f857ac35868fd80531050ad8b6091716
ToppCellIIF-Lymphocyte-T_NK-T_NK_proliferative|IIF / Disease, Lineage and Cell Type

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.25e-06184836ab8b45ce40e8c5f66e5c23332a591b4f9cba4ce1
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 DTL MCM10 PRC1 MELK BDKRB2

1.25e-061848366b2449ac65a2322aa0479fba0d89828f243aabbe
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 DTL MCM10 PRC1 MELK BDKRB2

1.25e-06184836e90622b82fa7f16a1faaf7a4724c958f2d83341d
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l33-52|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ESCO2 LMLN DTL MCM10 PRC1 RRM1

1.29e-0618583647c69500877b851c0c9744f5e1ef2ee0bff99168
ToppCelldroplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.29e-0618583657c1eb50a4456d20953e48d5dc3b0ea3d0d81b6d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AKT3 MCTP1 SCNN1B MYO1B SDK1 ACOT12

1.38e-06187836e3095455d2f255854f339f6b05fa87852af0700f
ToppCellFibroblast-E_(Early_Fibroblastic_progenitor)|World / shred on cell class and cell subclass (v4)

ESCO2 ANO2 DTL PRC1 RRM1 MELK

1.42e-06188836be3db9768364568f44e32ae6b3bf99e49b0978bb
ToppCellMultiple_Sclerosis-Lymphocyte-T_NK-T_NK_proliferative|Multiple_Sclerosis / Disease, Lineage and Cell Type

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.42e-061888366c05797a5d0635d89ffcf4aca52178687129ccb4
ToppCell367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.42e-06188836f5102e8d95506c25c675094b86162a6a50087b64
ToppCellNS-critical-d_0-4-Lymphoid-NKT-proliferating|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ESCO2 ZWILCH DTL MCM10 PRC1 MELK

1.46e-06189836d6bd46abb072b13a6b72f1ca25d19f218cceb1ff
ToppCellnormal-na-Lymphocytic|normal / PBMC cell types (v2) per disease, treatment status, and sex

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.46e-061898361d382f8eb998c6a30e09fddc9a427afc8f5f7323
ToppCellnormal-na-Lymphocytic-lymphocyte|normal / PBMC cell types (v2) per disease, treatment status, and sex

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.46e-06189836b83fd81ecc5ef363be7435ee12cb7079e2434af7
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.46e-06189836fd8834d1feb7f63911c5fa51efb1f679a8baddeb
ToppCellnormal-na-Lymphocytic-lymphocyte-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.46e-061898363db4177d68cab4cd16842d2ebcaca28f69300e44
ToppCellnormal_Pleural_Fluid-T/NK_cells-Undetermined|normal_Pleural_Fluid / Location, Cell class and cell subclass

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.51e-06190836165c61443ff0c8efbdad3b052bb00f46d81c5203
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.56e-0619183615dbc5a03bfab8931c0fd385b0f25874736ae874
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.56e-06191836d6e158f16a183c9203c057192342e9b83e79bc89
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.56e-061918367cb5c6f2cf27f3503d1b313e402a7410dfe6473e
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD4/8-lo-Cycling_T|bone_marrow / Manually curated celltypes from each tissue

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.56e-06191836210a0f1a71df2508cbfc73d6868a2122338b9a1c
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.56e-0619183645c15f5ce4a207ac944bed65d45f06c1657d1a6d
ToppCellP03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ESCO2 ZWILCH MCM10 PRC1 RRM1 MELK

1.56e-06191836b978afe76754cc56e1672abca27be289bb56375b
ToppCellProliferating|World / shred by cell class for mouse tongue

ESCO2 ZWILCH MCM10 PRC1 RRM1 MELK

1.60e-06192836f081f3f957cc782294e118fcc1055f6a4264ee98
ToppCellNS-moderate-d_0-4-Lymphoid|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ESCO2 AOAH DTL MCM10 PRC1 MELK

1.60e-06192836905217dcfc843d3469e9e71bd33707863b14cc82
ToppCellRV-10._Endothelium_II|RV / Chamber and Cluster_Paper

DOCK4 ANO2 AKT3 DOCK9 NRG3 IL6ST

1.65e-0619383601c2df9206f1527c578e808978e58196c35e72f5
ToppCellSevere_COVID-19-Myeloid-proliferating_Myeloid_cells|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

ESCO2 DST DTL MCM10 PRC1 RRM1

1.65e-061938360d85025690c9cd545cba30abc38acbdd6a39b153
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 TGFBR2 FAT4 AKT3 NRG3 IL6ST

1.65e-06193836456aa8a8f1f9cbba0bd618a5f623909079c0f56b
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

DOCK4 ANO2 AKT3 DOCK9 NRG3 IL6ST

1.65e-061938362531266bc57339d4e2b22a88817008e32b8c1598
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.65e-06193836e45ce9cf8421512b57f157c24b64793b47b4ba4b
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.70e-06194836f39a471293ecc5c5967b00e772b8f48ebc9affbe
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ESCO2 DST DTL MCM10 PRC1 RRM1

1.70e-06194836cb39850e9577015b6b9834e98c36b412bae7d462
ToppCell3'_v3-Lung-Myeloid_Mac-Cycling_Myeloid-Mac|Lung / Manually curated celltypes from each tissue

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.70e-06194836a8ae49157ca3f9e8b3f1750a995aee012dc859b6
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ESCO2 DST DTL MCM10 PRC1 RRM1

1.70e-06194836408597c9aa302a44b112c1d612c21fbb0227a82a
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ESCO2 DST DTL MCM10 PRC1 RRM1

1.70e-06194836193cc20fefbd795a4ad59e401a95af47d30603e7
ToppCellBAL-Severe-Myeloid-Myeloid|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ESCO2 DST DTL MCM10 PRC1 RRM1

1.70e-061948362360b5f995b360419de41612368cab9fb61781a1
ToppCellwk_20-22-Hematologic_Lymphocytic-B-Pro-B|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.70e-061948363590ff471f74a361ee5bf02a58e3104cd3bf7d00
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.70e-06194836f9070035553bc68106a9e0bdf4b507715a138aba
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ESCO2 DST DTL MCM10 PRC1 RRM1

1.70e-06194836903ae11708b0cb24538c6982abd57fe6fa95b8d3
ToppCellControl-Lymphoid_T/NK-T/NK_proliferative|Control / Disease group, lineage and cell class

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.70e-061948369bbb124001fba7450f4639f47f9b720a483e7242
ToppCellLPS-IL1RA-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT4 AKT3 DST MCTP1 DOCK9 DTL

1.70e-0619483643f92b0533e26633dc94cce554045d641ef8fd76
ToppCellControl-Lymphocyte-T_NK-T_NK_proliferative|Control / Disease, Lineage and Cell Type

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.70e-06194836844731b7943d1cfca819b7b89e4e62067bfa0230
ToppCellBAL-Severe-Myeloid-Myeloid|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ESCO2 DST DTL MCM10 PRC1 RRM1

1.70e-0619483658406502a8cbcc3037f79a1b6a683df408297ae5
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.70e-06194836a75ecd0b0a928d4646602f7d16a645f6b3df3af5
ToppCellLPS-IL1RA-Endothelial-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT4 AKT3 DST MCTP1 DOCK9 DTL

1.70e-061948361d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.70e-061948364c1d13d8cb6fb424655c67755ee6dbaf59d6b418
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.70e-0619483617744fd6645cf5a447a01a83f07e8d305c2bcd9c
ToppCell(7)_Epithelial_cells-(7)_Epithelial-J_(AT1-AT2_progenitors)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

ESCO2 ZWILCH MCM10 PRC1 RRM1 MELK

1.70e-061948364d6ae2b25db11a4ae6dadee83be5c8c05b1225c3
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating|367C / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 ZWILCH DTL MCM10 PRC1 MELK

1.70e-06194836a12b64945e10f00aa983678a02586c59badc1570
ToppCellcontrol-Lymphocytic-Prol._cells|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ESCO2 ZWILCH DTL MCM10 RRM1 MELK

1.70e-061948364c76508de3291c952386caffda2d559629ba5998
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ESCO2 DTL MCM10 PRC1 RRM1 MELK

1.70e-06194836e14f66f7584909621b776292fbd52808273fd2ee
ToppCell(7)_Epithelial-J_(AT1-AT2_progenitors)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

ESCO2 ZWILCH MCM10 PRC1 RRM1 MELK

1.76e-0619583670e6b58c502a2abeb4e36bed179020c675468bd4
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ESCO2 ZWILCH DTL MCM10 RRM1 MELK

1.76e-06195836cec7df321f372d05c94f97d6bb18891a5cc3dec3
Drugbenzoyl-S-CoA

ESCO2 DBT ESCO1 ARAF ACOT12

2.24e-0658835CID000122174
DrugGuanabenz acetate [23256-50-0]; Up 200; 13.8uM; PC3; HT_HG-U133A

AKT3 GGA2 CLCN5 DBT ANAPC5 ITPR1 ZNF3

7.03e-061948374642_UP
DrugFluoxetine hydrochloride [59333-67-4]; Down 200; 11.6uM; PC3; HT_HG-U133A

USP8 AKT3 GGA2 DBT PLEKHO1 SBNO2 ITPR1

7.52e-061968376757_DN
DrugC04424

ESCO2 DBT ESCO1

7.55e-0611833CID011953835
DrugNaringin hydrate [11032-30-7]; Down 200; 6.6uM; HL60; HT_HG-U133A

GGA2 MACF1 C5 SNX16 DBT RRM1 TTF1

8.03e-061988372425_DN
DrugC05118

ESCO2 DBT ESCO1

1.00e-0512833CID000440565
DrugC05119

ESCO2 DBT ESCO1

1.00e-0512833CID000440566
DrugAC1L9EUB

ESCO2 DBT ESCO1

1.30e-0513833CID000443527
DrugAC1LCVO5

ESCO2 DBT ESCO1

1.65e-0514833CID000656890
DrugAC1L9EU8

ESCO2 DBT ESCO1

1.65e-0514833CID000443526
DrugIC261

LMLN DNAH17 DNAH9 BDKRB2 DNAH11

2.69e-0596835CID000003674
DrugAC1L9ASI

ESCO2 DBT ESCO1

3.06e-0517833CID000441230
Drug2,4,4'-trichlorobiphenyl

ESCO2 SPTLC3 ZWILCH AKT3 TRANK1 MCTP1 MYO1B MCM10 MLXIP NRG3 PRC1 RRM1 MELK ESCO1 MPTX1 ITPR1

4.33e-0514118316ctd:C081766
Drug2,4,5,2',5'-pentachlorobiphenyl

ESCO2 SPTLC3 ZWILCH AKT3 TRANK1 MCTP1 MYO1B MCM10 MLXIP NRG3 PRC1 RRM1 MELK ESCO1 MPTX1 ITPR1

5.57e-0514418316ctd:C009828
DrugHomatropine hydrobromide (R,S) [51-56-9]; Down 200; 11.2uM; PC3; HT_HG-U133A

TGFBR2 GGA2 UGT8 SNX16 DBT ANAPC5

7.32e-051928365058_DN
Drug2-propylpentanoic acid; Down 200; 50uM; MCF7; HT_HG-U133A

GGA2 PIK3CA MYO1B C5 RRM1 ANAPC5

7.32e-051928361647_DN
DrugSTOCK1N-35215; Up 200; 10uM; MCF7; HT_HG-U133A

PHEX SPTLC3 AKT3 DNAH17 SCNN1B ZNF3

7.54e-051938366422_UP
DrugProchlorperazine dimaleate [84-02-6]; Up 200; 6.6uM; MCF7; HT_HG-U133A

KLHL29 FAT4 DOCK9 DBT IL6ST SBNO2

8.44e-051978362641_UP
DrugThiorphan [76721-89-6]; Up 200; 15.8uM; MCF7; HT_HG-U133A

DOCK4 DRD2 DBT DNAH9 IL6ST ITPR1

8.44e-051978362752_UP
DrugFluorocurarine chloride [22273-09-2]; Up 200; 11.6uM; MCF7; HT_HG-U133A

ANO2 DRD2 SCNN1B LRP2 NIPAL3 ITPR1

8.44e-051978366083_UP
DrugDebrisoquin sulfate [581-88-4]; Up 200; 9uM; PC3; HT_HG-U133A

PHEX AKT3 DRD2 DOCK9 MYO1B MLXIP

8.44e-051978366688_UP
DrugClindamycin hydrochloride [21462-39-5]; Up 200; 8.6uM; PC3; HT_HG-U133A

KLHL29 DRD2 GGA2 DOCK9 DBT IL6ST

8.68e-051988362057_UP
Drug5140203; Up 200; 15uM; MCF7; HT_HG-U133A_EA

SPTLC3 CLCN5 MYO1B C5 ANAPC5 BDKRB2

8.68e-05198836908_UP
DrugEthotoin [86-35-1]; Up 200; 19.6uM; MCF7; HT_HG-U133A

KLHL29 ANO2 DOCK9 DNAH17 MUC2 ITPR1

8.68e-051988363892_UP
DrugNifedipine [21829-25-4]; Down 200; 11.6uM; PC3; HT_HG-U133A

TGFBR2 GGA2 MCTP1 XPA C5 DBT

8.68e-051988367303_DN
DiseaseVitamin D-Resistant Rickets, X-Linked

PHEX CLCN5

7.44e-062812C3536984
DiseaseHypophosphatemic Rickets, X-Linked Dominant

PHEX CLCN5

7.44e-062812C0733682
DiseaseRickets, X-Linked Hypophosphatemic

PHEX CLCN5

7.44e-062812C3540852
DiseaseHypophosphatemic Rickets, X-Linked Recessive

PHEX CLCN5

7.44e-062812C1845168
DiseaseWeight Gain

ZWILCH DRD2 PIK3CA MYO1B DNAH11

9.30e-06102815C0043094
Diseasehair morphology measurement

MCTP1 AOAH MLXIP NRG3

1.50e-0554814EFO_0007821
Diseaseamino acid measurement

KLHL29 ANO2 FAT4 NPSR1 SCNN1B LRP2 C5 MLXIP NRG3 MUC2

1.66e-056788110EFO_0005134
DiseaseFamilial Hypophosphatemic Rickets

PHEX CLCN5

2.23e-053812C3536983
Diseasemorphine dependence (biomarker_via_orthology)

DRD2 NPSR1

2.23e-053812DOID:2560 (biomarker_via_orthology)
DiseaseMegalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome

AKT3 PIK3CA

4.45e-054812C1863924
DiseaseRoberts syndrome (implicated_via_orthology)

ESCO2 ESCO1

4.45e-054812DOID:5325 (implicated_via_orthology)
DiseaseCleft palate

PHEX POMGNT2 SCNN1B NIPAL3

4.45e-0571814HP_0000175
DiseaseHypophosphatemic rickets

PHEX CLCN5

7.40e-055812cv:C1704375
DiseaseHereditary hypophosphatemic rickets

PHEX CLCN5

7.40e-055812cv:CN296404
DiseaseRickets

PHEX CLCN5

7.40e-055812cv:C0035579
DiseaseHemimegalencephaly

AKT3 PIK3CA

1.11e-046812C0431391
Diseaseasthma (implicated_via_orthology)

C5 BDKRB2 ITPR1

1.22e-0435813DOID:2841 (implicated_via_orthology)
Diseaseprimary immunodeficiency disease (is_implicated_in)

MCM10 IL6ST POLR3F

2.12e-0442813DOID:612 (is_implicated_in)
DiseaseBipolar Disorder

DRD2 TRANK1 DOCK9 NRG3 PLEKHO1 BDKRB2 ITPR1

3.43e-04477817C0005586
DiseaseC-reactive protein measurement

DOCK4 AKT3 RBM25 TRANK1 DNAH17 MACF1 ANAPC5 MPTX1 ITPR1 DNAH11 ZNF3

4.48e-0412068111EFO_0004458
DiseaseIntestinal Neoplasms

XPA MUC2

4.83e-0412812C0021841
DiseaseIntestinal Cancer

XPA MUC2

4.83e-0412812C0346627
Diseasemelanoma

FAT4 AKT3 PIK3CA MYO1B XPA

6.14e-04248815C0025202
DiseaseMalformations of Cortical Development

AKT3 PIK3CA

6.63e-0414812C1955869
DiseaseCortical Dysplasia

AKT3 PIK3CA

6.63e-0414812C0431380
Diseasecancer (implicated_via_orthology)

AKT3 DST MACF1 NOP2 ARAF

8.69e-04268815DOID:162 (implicated_via_orthology)
Diseaseasthma (is_implicated_in)

NPSR1 C5 MUC2 BDKRB2

9.34e-04157814DOID:2841 (is_implicated_in)
Diseaseadenosine monophosphate measurement

MYO1B RRM1

1.11e-0318812EFO_0010454
Diseasesensorineural hearing loss (implicated_via_orthology)

DNAH17 DNAH9

1.23e-0319812DOID:10003 (implicated_via_orthology)
DiseaseCorneal astigmatism

DOCK9 AOAH BDKRB2

1.26e-0377813EFO_1002040
DiseaseBronchiectasis

SCNN1B DNAH11

1.66e-0322812C0006267
Diseasevisual epilepsy (biomarker_via_orthology)

RTN4 RRM1 IL6ST

1.97e-0390813DOID:11832 (biomarker_via_orthology)
Diseasegout

DST LRP2 MLXIP BDKRB2

2.11e-03196814EFO_0004274
DiseaseHereditary non-polyposis colorectal cancer syndrome

TGFBR2 PIK3CA

2.50e-0327812C1112155
DiseaseAdenocarcinoma of lung (disorder)

PIK3CA RRM1 TTF1 ARAF

2.52e-03206814C0152013
DiseasePigmented Basal Cell Carcinoma

PIK3CA XPA

2.69e-0328812C1368275
DiseaseLiver carcinoma

PIK3CA DTL MCM10 PRC1 RRM1 MELK

2.73e-03507816C2239176

Protein segments in the cluster

PeptideGeneStartEntry
IVREKLYKGISWVEV

TTF1

711

Q15361
GVIEDWKRITKLDIY

ACSM6

351

Q6P461
VYVIVGKRFRKKSWE

BDKRB2

331

P30411
VIDYIDTIWKILKPG

CARNMT1

321

Q8N4J0
WRVKGKTIKEVAEAY

ALDH1L2

81

Q3SY69
KIQKYVVWIEARDGG

FAT4

2631

Q6V0I7
LKGLWDVIIYVRRSI

DNAH11

1326

Q96DT5
RGWEVTSTVEKIKIY

ACOT12

366

Q8WYK0
VDGIIKVWDLRKNYT

DTL

236

Q9NZJ0
LDEIYGAVAKWLTKI

ANO2

596

Q9NQ90
IVKEGWVQKRGEYIK

AKT3

6

Q9Y243
IRPWINKKIIEYIGE

RBM25

771

P49756
LKGDAWVYKRLVEDI

MELK

631

Q14680
IKDWVTPYKIAVLVL

ANAPC5

26

Q9UJX4
TVGIKEKSIYLRLWK

AOAH

311

P28039
LKWIVVGSVKEYVPT

NRG3

86

P56975
IREVTVKEWYVKEGD

DBT

76

P11182
KVYRALWRGEEVAVK

MAP3K10

111

Q02779
IASAIIGIIFIKEKW

NIPAL3

111

Q6P499
LRYIVLVWGINKFTK

MCTP1

936

Q6DN14
GIVIRTIWIKSKTYE

NPSR1

231

Q6W5P4
QLRSIVEKSELWVYK

ITPR1

1131

Q14643
IKRLYKLLEIWIEFG

DST

331

Q03001
TYEIIFKIVGTKWLA

DOP1B

86

Q9Y3R5
LGLYQWSDKVVRKVE

LMLN

311

Q96KR4
YIISEELISEGKWVK

NUDT5

16

Q9UKK9
IIVIWDKRTTVFIKL

MUC2

966

Q02817
TGVEYIVTVKIGWTK

CSTL1

76

Q9H114
VNIAVIKYWGKRDEE

MVD

16

P53602
IKYWGKRDEELVLPI

MVD

21

P53602
DSKSVKEIYIRGWKV

LRRC71

136

Q8N4P6
KEIYIRGWKVEERIL

LRRC71

141

Q8N4P6
KVKGRVIEILFSWTV

GGA2

126

Q9UJY4
IEVAKLDGRYRKWLI

LRP2

4166

P98164
EIDWVTFGVILKKVT

MCM10

291

Q7L590
KVREVKYEVWLQEQG

POMGNT2

516

Q8NAT1
SDLVEIYLWKLVKGI

CHRDL2

361

Q6WN34
IYNKLDKGQIIVVIW

PIK3CA

181

P42336
KGRIEELYKLLEVWI

MACF1

371

Q9UPN3
ELYKLLEVWIEFGRI

MACF1

376

Q9UPN3
KVTQEVIDYRRWIKE

TENT4A

516

Q5XG87
TEGKYWKSRIEIVIR

MLXIP

206

Q9HAP2
VYRLIKGRKTVTAWD

ARAF

61

P10398
VEWTTPRESVKKYIL

IL6ST

441

P40189
RDLIKVLKWYVDRIT

DOCK4

676

Q8N1I0
KKRDVVETQVGYSWL

DOCK9

746

Q9BZ29
VGWYNEIKTIVKAVE

DNAH17

721

Q9UFH2
TKGRVKLVIFVIWAV

GHSR

156

Q92847
EIKKVWYGRTIIRSA

DIS3L

571

Q8TF46
TWFGKEILVKTLRVV

C5

916

P01031
GILLEWKTVTEKELY

UGT8

396

Q16880
IIRGYLGKWTLVIKT

CLCN5

251

P51795
EGIKYVGWKKERVVA

ESCO2

416

Q56NI9
SAVKYVGWKKERILA

ESCO1

646

Q5FWF5
VIKWSYQVQVVLKRE

DNAH9

221

Q9NYC9
VVYLEVVGEWKFSRI

DRD2

91

P14416
ADKYEIKIWPIGREI

FBXW2

296

Q9UKT8
QRWLKVRDLTKGVTY

SDK1

1861

Q7Z5N4
GEIIIDFVWITIIKL

SCNN1B

541

P51168
WVIDKYGKNEVLRFT

RTN4IP1

46

Q8WWV3
VDLLYWRDIKKTGVV

RTN4

1006

Q9NQC3
EIVRTKEYEGNLTWK

TAS2R31

151

P59538
LSVLRQVRYWVKGEK

TAS2R31

291

P59538
KKVIEAIRVELVQYW

PRC1

291

O43663
EERKTELGKQYWLIT

TGFBR2

311

P37173
QVVFYKISVDRGLKW

SBNO2

1036

Q9Y2G9
VWKGYSVGEEAKIIL

MPTX1

56

A8MV57
VWKYICELGISKVEL

POLR3F

216

Q9H1D9
RRAWKKILILVEGVY

SPTLC3

296

Q9NUV7
WVVDYALKKRNVRLV

NOP2

526

P46087
IFREIWKNRYVVLKG

PLEKHO1

36

Q53GL0
TYVKEIEVWRRLVEI

RNF213

931

Q63HN8
WRVEIYSGQKKIKTV

ZWILCH

531

Q9H900
VAVYFIRKEWKRLEP

ZNF3

56

P17036
TGKLLWKVRYDTFIV

WDR88

176

Q6ZMY6
RKVVKAQQLWYAIIE

RRM1

381

P23921
TIKLWDYIDGILIKT

WDR75

81

Q8IWA0
QFDWLGYIKKVIDTR

PHEX

311

P78562
YLKLQIVKRSLEVWG

XPA

181

P23025
KLVALYTVWVALKEV

PIEZO1

816

Q92508
KSGRIYTEIIRIWDI

TRANK1

886

O15050
VYKILVKKTPEESWV

SNX16

126

P57768
TWKKRGNVEYVVLLD

USP8

246

P40818
RIVVLGIWDYIENKI

TMEM266

156

Q2M3C6
KQRIIWGYKILFLDV

UGGT1

1331

Q9NYU2
TKAEELVYETVIKWI

KLHL29

491

Q96CT2
VIQSYIRGWKARKIL

MYO1B

756

O43795