Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cadherin binding	MMP24 SND1 DOCK9 SPTBN1 EIF5 MACF1 NCK1 SEPTIN7	5.30e-05	339	78	8	GO:0045296
GeneOntologyMolecularFunction	eukaryotic initiation factor eIF2 binding	EIF5 NCK1	8.99e-05	4	78	2	GO:0071074
GeneOntologyMolecularFunction	phosphatidic acid transfer activity	PRELID3A PRELID3B	3.12e-04	7	78	2	GO:1990050
GeneOntologyMolecularFunction	cell adhesion molecule binding	MMP24 TENM3 SND1 DOCK9 SPTBN1 EIF5 MACF1 NCK1 SEPTIN7	5.35e-04	599	78	9	GO:0050839
GeneOntologyBiologicalProcess	dense core granule docking	UNC13B UNC13A	1.38e-05	2	77	2	GO:0061790
GeneOntologyBiologicalProcess	regulation of embryonic cell shape	DAG1 SEPTIN7	4.12e-05	3	77	2	GO:0016476
GeneOntologyBiologicalProcess	dense core granule priming	UNC13B UNC13A	8.21e-05	4	77	2	GO:0061789
GeneOntologyBiologicalProcess	microtubule-based movement	FSIP2 SLC9C1 SYNE2 SPG11 CFAP43 CFAP61 DNAH8 MADD HNRNPU	9.03e-05	493	77	9	GO:0007018
GeneOntologyCellularComponent	cytoplasmic region	UNC13B ARFGEF2 CFAP43 CFAP61 SEPTIN7 DNAH8 UNC13A MADD HNRNPU	7.73e-06	360	78	9	GO:0099568
GeneOntologyCellularComponent	cell cortex	UNC13B SPTBN1 DVL2 OSBPL8 MACF1 SEPTIN7 UNC13A ITPR2	7.25e-05	371	78	8	GO:0005938
GeneOntologyCellularComponent	axon	UNC13B TENM3 SCN1A SPTBN1 DNM3 DAG1 SPG11 SEPTIN7 UNC13A MADD CA2 ITPR2	1.09e-04	891	78	12	GO:0030424
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	ARFGEF2 CFAP43 CFAP61 SEPTIN7 DNAH8 MADD HNRNPU	1.81e-04	317	78	7	GO:0032838
GeneOntologyCellularComponent	proteasome core complex, alpha-subunit complex	PSMA2 PSMA8	3.79e-04	8	78	2	GO:0019773
GeneOntologyCellularComponent	axoneme	ARFGEF2 CFAP43 CFAP61 SEPTIN7 DNAH8	1.07e-03	207	78	5	GO:0005930
GeneOntologyCellularComponent	ciliary plasm	ARFGEF2 CFAP43 CFAP61 SEPTIN7 DNAH8	1.09e-03	208	78	5	GO:0097014
HumanPheno	Absent sperm flagella	FSIP2 CFAP43 CFAP61 DNAH8	1.81e-05	28	30	4	HP:0032558
HumanPheno	Coiled sperm flagella	FSIP2 CFAP43 CFAP61 DNAH8	3.14e-05	32	30	4	HP:0032560
HumanPheno	Short sperm flagella	FSIP2 CFAP43 CFAP61 DNAH8	3.55e-05	33	30	4	HP:0032559
HumanPheno	Irregularly shaped sperm tail	FSIP2 CFAP61 DNAH8	8.00e-05	15	30	3	HP:0033393
HumanPheno	Abnormal sperm tail morphology	FSIP2 CFAP43 CFAP61 DNAH8	1.03e-04	43	30	4	HP:0012868
Domain	Unc-13	UNC13B UNC13A	5.02e-05	3	77	2	IPR027080
Domain	Actinin_actin-bd_CS	SPTBN1 SYNE2 MACF1	1.12e-04	23	77	3	IPR001589
Domain	Spectrin	SPTBN1 SYNE2 MACF1	1.12e-04	23	77	3	PF00435
Domain	ACTININ_2	SPTBN1 SYNE2 MACF1	1.12e-04	23	77	3	PS00020
Domain	ACTININ_1	SPTBN1 SYNE2 MACF1	1.12e-04	23	77	3	PS00019
Domain	Munc13_dom-2	UNC13B UNC13A	1.66e-04	5	77	2	IPR014772
Domain	Membr_traf_MHD	UNC13B UNC13A	1.66e-04	5	77	2	PF10540
Domain	MHD2	UNC13B UNC13A	1.66e-04	5	77	2	PS51259
Domain	Munc13_subgr_dom-2	UNC13B UNC13A	1.66e-04	5	77	2	IPR019558
Domain	DUF1041	UNC13B UNC13A	1.66e-04	5	77	2	SM01145
Domain	Spectrin_repeat	SPTBN1 SYNE2 MACF1	2.28e-04	29	77	3	IPR002017
Domain	PRELI_MSF1	PRELID3A PRELID3B	2.49e-04	6	77	2	PS50904
Domain	PRELI	PRELID3A PRELID3B	2.49e-04	6	77	2	PF04707
Domain	PRELI/MSF1_dom	PRELID3A PRELID3B	2.49e-04	6	77	2	IPR006797
Domain	Spectrin/alpha-actinin	SPTBN1 SYNE2 MACF1	3.07e-04	32	77	3	IPR018159
Domain	SPEC	SPTBN1 SYNE2 MACF1	3.07e-04	32	77	3	SM00150
Domain	DUF1041	UNC13B UNC13A	3.48e-04	7	77	2	PF06292
Domain	Munc13_1	UNC13B UNC13A	3.48e-04	7	77	2	IPR014770
Domain	CAPS_dom	UNC13B UNC13A	3.48e-04	7	77	2	IPR010439
Domain	MHD1	UNC13B UNC13A	3.48e-04	7	77	2	PS51258
Domain	Proteasome_suA-type	PSMA2 PSMA8	4.62e-04	8	77	2	IPR023332
Domain	Proteasome_asu_N	PSMA2 PSMA8	4.62e-04	8	77	2	IPR000426
Domain	Proteasome_A_N	PSMA2 PSMA8	4.62e-04	8	77	2	SM00948
Domain	Proteasome_A_N	PSMA2 PSMA8	4.62e-04	8	77	2	PF10584
Domain	PROTEASOME_ALPHA_2	PSMA2 PSMA8	4.62e-04	8	77	2	PS51475
Domain	PROTEASOME_ALPHA_1	PSMA2 PSMA8	4.62e-04	8	77	2	PS00388
Domain	C1_1	UNC13B DGKZ UNC13A	1.68e-03	57	77	3	PF00130
Domain	Diacylglycerol_kinase_cat_dom	CERKL DGKZ	1.70e-03	15	77	2	IPR001206
Domain	DAGK_cat	CERKL DGKZ	1.70e-03	15	77	2	PF00781
Domain	DAGK	CERKL DGKZ	1.70e-03	15	77	2	PS50146
Domain	NAD/diacylglycerol_kinase	CERKL DGKZ	2.19e-03	17	77	2	IPR016064
Domain	ZF_DAG_PE_1	UNC13B DGKZ UNC13A	2.34e-03	64	77	3	PS00479
Domain	ZF_DAG_PE_2	UNC13B DGKZ UNC13A	2.34e-03	64	77	3	PS50081
Domain	C1	UNC13B DGKZ UNC13A	2.45e-03	65	77	3	SM00109
Domain	CH	SPTBN1 SYNE2 MACF1	2.45e-03	65	77	3	SM00033
Domain	PE/DAG-bd	UNC13B DGKZ UNC13A	2.56e-03	66	77	3	IPR002219
Domain	Proteasome	PSMA2 PSMA8	2.74e-03	19	77	2	PF00227
Domain	Proteasome_sua/b	PSMA2 PSMA8	2.74e-03	19	77	2	IPR001353
Domain	CH	SPTBN1 SYNE2 MACF1	3.02e-03	70	77	3	PF00307
Domain	-	SPTBN1 SYNE2 MACF1	3.15e-03	71	77	3	1.10.418.10
Domain	CH	SPTBN1 SYNE2 MACF1	3.41e-03	73	77	3	PS50021
Domain	CH-domain	SPTBN1 SYNE2 MACF1	3.68e-03	75	77	3	IPR001715
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	CMBL RALGAPA1 SND1 BCLAF1 SPTBN1 EIF5 DVL2 OSBPL8 MACF1 NCK1 PEAK1 SEPTIN7 HNRNPU ANKS1A	5.69e-10	708	78	14	39231216
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	RBSN MIA3 BCLAF1 SCN1A DOCK9 SPTBN1 DVL2 OSBPL8 DAG1 MACF1 PEAK1 SEPTIN7 UNC13A YARS1 MADD HNRNPU	4.03e-09	1139	78	16	36417873
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	RALGAPA1 SND1 BCLAF1 SPTBN1 OSBPL8 ARFGEF2 MACF1 DGKZ PEAK1 SEPTIN7 NDUFB5 UNC13A YARS1 MADD CA2 HNRNPU ITPR2	1.47e-08	1431	78	17	37142655
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	TENM3 SND1 DOCK9 SPTBN1 EIF5 LRATD2 DAG1 MACF1 NCK1 PEAK1 SEPTIN7	5.50e-08	565	78	11	25468996
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	MIA3 SND1 BCLAF1 SPTBN1 ZNF280C MACF1 CHD1L YARS1 HNRNPU	1.20e-07	360	78	9	33111431
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	RALGAPA1 KRT17 BCLAF1 PSMA2 SPTBN1 MACF1 CHD1L SEPTIN7 MADD HNRNPU	3.54e-07	538	78	10	28524877
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RALGAPA1 FSIP2 RBSN SPTBN1 SYNE2 EIF5 OSBPL8 MACF1 PEAK1 MAP3K3 MADD ANKS1A	4.77e-07	861	78	12	36931259
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MIA3 BCLAF1 SPTBN1 SYNE2 DVL2 DNM3 MACF1 DGKZ SEPTIN7 UNC13A HNRNPU ANKS1A	1.54e-06	963	78	12	28671696
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	CMBL RBSN SYNE2 DVL2 OSBPL8 MACF1 SEPTIN7 HNRNPU ANKS1A	1.79e-06	498	78	9	36634849
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	MIA3 BCLAF1 PSMA2 SPTBN1 EIF5 DNM3 MACF1 DGKZ SEPTIN7 NDUFB5 HNRNPU	2.95e-06	847	78	11	35235311
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	KRT17 DCPS SND1 PSMA2 SPTBN1 EIF5 DVL2 ARFGEF2 MACF1 SEPTIN7 USP19 YARS1 HNRNPU ANKS1A	3.94e-06	1455	78	14	22863883
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	TENM3 BCLAF1 SCN1A SYNE2 DNAH8 HNRNPU	4.15e-06	187	78	6	26460568
Pubmed	Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming.	UNC13B UNC13A	4.97e-06	2	78	2	12070347
Pubmed	Regulation of insulin exocytosis by Munc13-1.	UNC13B UNC13A	4.97e-06	2	78	2	12871971
Pubmed	Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity.	UNC13B UNC13A	4.97e-06	2	78	2	17561838
Pubmed	Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors.	UNC13B UNC13A	4.97e-06	2	78	2	23070049
Pubmed	Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.	UNC13B UNC13A	4.97e-06	2	78	2	28489077
Pubmed	Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.	UNC13B UNC13A	4.97e-06	2	78	2	10440375
Pubmed	Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.	UNC13B UNC13A	4.97e-06	2	78	2	22066784
Pubmed	Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.	UNC13B UNC13A	4.97e-06	2	78	2	32187536
Pubmed	Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.	UNC13B UNC13A	4.97e-06	2	78	2	28772123
Pubmed	Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.	UNC13B UNC13A	4.97e-06	2	78	2	17267576
Pubmed	Role of mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1) in the recruitment of newcomer insulin granules in both first and second phases of glucose-stimulated insulin secretion in mouse islets.	UNC13B UNC13A	4.97e-06	2	78	2	22814762
Pubmed	Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.	UNC13B UNC13A	4.97e-06	2	78	2	28426965
Pubmed	A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution.	UNC13B UNC13A	4.97e-06	2	78	2	35613050
Pubmed	Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling.	UNC13B UNC13A	4.97e-06	2	78	2	23770256
Pubmed	Membrane bridging by Munc13-1 is crucial for neurotransmitter release.	UNC13B UNC13A	4.97e-06	2	78	2	30816091
Pubmed	A common molecular basis for membrane docking and functional priming of synaptic vesicles.	UNC13B UNC13A	4.97e-06	2	78	2	19558619
Pubmed	Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C.	UNC13B UNC13A	4.97e-06	2	78	2	18701688
Pubmed	Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses.	UNC13B UNC13A	4.97e-06	2	78	2	31851910
Pubmed	Differential control of vesicle priming and short-term plasticity by Munc13 isoforms.	UNC13B UNC13A	4.97e-06	2	78	2	11832228
Pubmed	Munc13 controls the location and efficiency of dense-core vesicle release in neurons.	UNC13B UNC13A	4.97e-06	2	78	2	23229896
Pubmed	Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs.	UNC13B UNC13A	4.97e-06	2	78	2	11792326
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	UNC13B SUPT20H SPTBN1 OSBPL8 DNM3 ARFGEF2 MACF1 NCK1 SEPTIN7 SKIL NDUFB5 YARS1 MADD	5.32e-06	1285	78	13	35914814
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	DCPS SND1 BCLAF1 SPTBN1 SYNE2 EIF5 DVL2 DAG1 FAM114A2 SIN3A SEPTIN7 USP19 HNRNPU	1.03e-05	1367	78	13	32687490
Pubmed	Munc13- and SNAP25-dependent molecular bridges play a key role in synaptic vesicle priming.	UNC13B UNC13A	1.49e-05	3	78	2	37343100
Pubmed	The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.	UNC13B UNC13A	1.49e-05	3	78	2	23658173
Pubmed	Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.	UNC13B UNC13A	1.49e-05	3	78	2	17639022
Pubmed	Association Study of GWAS-Derived Loci with Height in Brazilian Children: Importance of MAP3K3, MMP24 and IGF1R Polymorphisms for Height Variation.	MMP24 MAP3K3	1.49e-05	3	78	2	26304632
Pubmed	Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.	UNC13B UNC13A	1.49e-05	3	78	2	33105896
Pubmed	Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.	UNC13B UNC13A	1.49e-05	3	78	2	22966208
Pubmed	Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.	UNC13B UNC13A	1.49e-05	3	78	2	15988013
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	RALGAPA1 RBSN SYNE2 OSBPL8 ARFGEF2 SPG11 MADD ITPR2	1.77e-05	504	78	8	34432599
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KRT17 SND1 BCLAF1 PSMA2 SPTBN1 SYNE2 PKHD1 MACF1 FAM114A2 SPG11 DNAH8 PSMA8 HNRNPU	1.81e-05	1442	78	13	35575683
Pubmed	Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity.	CMBL METTL21A OR2T35 BCLAF1 PSMA2 HNRNPU ANKS1A	2.16e-05	374	78	7	23824909
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	MIA3 SND1 SYNE2 EIF5 DVL2 OSBPL8 ITPR2	2.19e-05	375	78	7	32788342
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	RALGAPA1 AIFM2 MIA3 SND1 BCLAF1 SPTBN1 SYNE2 OSBPL8 MACF1 SPG11 PEAK1 NDUFB5 ITPR2	2.50e-05	1487	78	13	33957083
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	BCLAF1 SPTBN1 SIN3A MADD HNRNPU	2.76e-05	156	78	5	22952844
Pubmed	Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo.	UNC13B UNC13A	2.97e-05	4	78	2	10488064
Pubmed	Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.	UNC13B UNC13A	2.97e-05	4	78	2	19996097
Pubmed	Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing.	UNC13B UNC13A	2.97e-05	4	78	2	15123597
Pubmed	ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.	UNC13B UNC13A	2.97e-05	4	78	2	28264913
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	UNC13B TENM3 DOCK9 DNM3 MACF1 USP19 MADD	3.69e-05	407	78	7	12693553
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	MIA3 SPTBN1 SYNE2 EIF5 DVL2 OSBPL8 FAM114A2 NCK1	4.14e-05	568	78	8	37774976
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	SND1 BCLAF1 ZNF280C EIF5 DVL2 MACF1 FAM114A2 SIN3A HNRNPU ANKS1A	4.49e-05	934	78	10	33916271
Pubmed	An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.	UNC13B UNC13A	4.94e-05	5	78	2	34706221
Pubmed	Viral ski inhibits retinoblastoma protein (Rb)-mediated transcriptional repression in a dominant negative fashion.	SIN3A SKIL	4.94e-05	5	78	2	9988677
Pubmed	A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.	UNC13B UNC13A	4.94e-05	5	78	2	32755572
Pubmed	RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.	UNC13B UNC13A	4.94e-05	5	78	2	22248876
Pubmed	Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission.	UNC13B UNC13A	4.94e-05	5	78	2	33139401
Pubmed	Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.	UNC13B UNC13A	4.94e-05	5	78	2	26575293
Pubmed	Genome-wide association study of smoking behaviours among Bangladeshi adults.	TENM3 ACOT12 ITPR2	6.18e-05	34	78	3	24665060
Pubmed	DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.	SND1 SIN3A HNRNPU	6.74e-05	35	78	3	24515614
Pubmed	Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles.	UNC13B UNC13A	7.40e-05	6	78	2	28635948
Pubmed	Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.	NCK1 SEPTIN7	7.40e-05	6	78	2	17803907
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	MIA3 BCLAF1 PSMA2 SPTBN1 ZNF280C OSBPL8 DAG1 SIN3A NDUFB5 CA2 HNRNPU	7.55e-05	1203	78	11	29180619
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	CMBL MIA3 SND1 PSMA2 SPTBN1 MACF1 PEAK1 CA2 HNRNPU	8.14e-05	807	78	9	30575818
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	RALGAPA1 TINF2 PSMA2 SYNE2 MACF1	8.37e-05	197	78	5	20811636
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	MIA3 TENM3 TINF2 SYNE2 MACF1 PEAK1	8.82e-05	322	78	6	26514267
Pubmed	Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins.	DAG1 NCK1	1.04e-04	7	78	2	11724572
Pubmed	A role for SKIP in EBNA2 activation of CBF1-repressed promoters.	SND1 SIN3A	1.04e-04	7	78	2	10644367
Pubmed	An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*.	SIN3A SKIL	1.04e-04	7	78	2	11306568
Pubmed	A genome-wide association meta-analysis of preschool internalizing problems.	PDE6C TENM3	1.04e-04	7	78	2	24839885
Pubmed	Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression.	SIN3A SKIL	1.04e-04	7	78	2	18212064
Pubmed	SNAREs and traffic.	UNC13B UNC13A	1.04e-04	7	78	2	15893389
Pubmed	Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.	UNC13B UNC13A	1.04e-04	7	78	2	36398873
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	KIAA0408 KRT17 XIRP2 DOCK9 SPTBN1 SYNE2 MACF1	1.29e-04	497	78	7	23414517
Pubmed	Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor.	SIN3A SKIL	1.38e-04	8	78	2	10049357
Pubmed	Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.	UNC13B UNC13A	1.38e-04	8	78	2	25609709
Pubmed	CFAP43 modulates ciliary beating in mouse and Xenopus.	CFAP43 SEPTIN7	1.38e-04	8	78	2	31884020
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	DOCK9 SYNE2 OSBPL8 DNM3 MACF1	1.56e-04	225	78	5	12168954
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	FSIP2 SND1 BCLAF1 SYNE2	1.74e-04	123	78	4	26912792
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	SND1 SPTBN1 SEPTIN7 PSMA8 YARS1	1.76e-04	231	78	5	36597993
Pubmed	RNF12 catalyzes BRF1 ubiquitination and regulates RNA polymerase III-dependent transcription.	KRT17 SND1 HNRNPU	1.97e-04	50	78	3	30413534
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	DOCK9 DNM3 MACF1 MADD	2.02e-04	128	78	4	30995482
Pubmed	Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis.	DAG1 MACF1	2.21e-04	10	78	2	33773096
Pubmed	SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming.	UNC13B UNC13A	2.21e-04	10	78	2	21040848
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	RALGAPA1 MIA3 OSBPL8 SPG11 NCK1 MADD ITPR2 ANKS1A	2.40e-04	733	78	8	34672954
Pubmed	FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy.	DCPS PSMA2 SEPTIN7 YARS1 HNRNPU	2.45e-04	248	78	5	32963011
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	SPTBN1 MACF1 DGKZ SEPTIN7 ANKS1A	2.59e-04	251	78	5	27507650
Pubmed	The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones.	UNC13B UNC13A	2.70e-04	11	78	2	25374362
Pubmed	Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors.	SPTBN1 MACF1	2.70e-04	11	78	2	39256359
Pubmed	Molecular and functional architecture of striatal dopamine release sites.	UNC13B UNC13A	2.70e-04	11	78	2	34767769
Pubmed	Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.	MIA3 EIF5 DAG1 DGKZ	3.09e-04	143	78	4	32560809
Pubmed	Many sequence variants affecting diversity of adult human height.	MMP24 DNM3 MAP3K3 ANKS1A	3.09e-04	143	78	4	18391951
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	MIA3 DVL2 MACF1 PEAK1 ANKS1A	3.20e-04	263	78	5	34702444
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	SND1 BCLAF1 SPTBN1 ZNF280C EIF5 PEAK1 SEPTIN7 USP19 YARS1 CA2 HNRNPU	3.29e-04	1425	78	11	30948266
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	SND1 SPTBN1 ARFGEF2 MACF1 CHD1L SEPTIN7 HNRNPU	3.36e-04	582	78	7	20467437
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	KRT17 SPTBN1 DNM3 PEAK1 HNRNPU	3.38e-04	266	78	5	19380743
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	RBSN FAT1 KRT17 TENM3 BCLAF1 ARFGEF2 PEAK1 USP19	3.54e-04	777	78	8	35844135
Interaction	KCNA3 interactions	CMBL RALGAPA1 SND1 BCLAF1 SPTBN1 EIF5 DVL2 PKHD1 OSBPL8 MACF1 NCK1 PEAK1 SEPTIN7 HNRNPU ANKS1A	8.75e-07	871	77	15	int:KCNA3
Interaction	LAMP2 interactions	RALGAPA1 RBSN SPTBN1 SYNE2 OSBPL8 ARFGEF2 SPG11 CHD1L PEAK1 SEPTIN7 USP19 HNRNPU	3.18e-06	609	77	12	int:LAMP2
Interaction	KCTD13 interactions	RALGAPA1 SND1 BCLAF1 SPTBN1 OSBPL8 ARFGEF2 MACF1 DGKZ PEAK1 SEPTIN7 NDUFB5 UNC13A YARS1 MADD CA2 HNRNPU ITPR2	1.59e-05	1394	77	17	int:KCTD13
Interaction	UBASH3B interactions	KRT17 SPTBN1 DNM3 NCK1 PEAK1 HNRNPU	3.05e-05	157	77	6	int:UBASH3B
Interaction	GAN interactions	KRT17 TENM3 BCLAF1 SCN1A SYNE2 DNAH8 HNRNPU	5.15e-05	253	77	7	int:GAN
Cytoband	2q24.3	XIRP2 SCN1A	3.37e-04	16	78	2	2q24.3
GeneFamily	UNC13 homologs	UNC13B UNC13A	4.85e-05	4	52	2	836
GeneFamily	SEC14 family\|PRELI domain containing	PRELID3A PRELID3B	1.21e-04	6	52	2	1295
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_500_k-means-cluster#4	UNC13B AIFM2 SYNE2 MACF1 DHX32	2.53e-05	98	75	5	Facebase_RNAseq_e10.5_Olfactory Pit_500_K4
ToppCell	Control-Control-Lymphocyte-T/NK-CD4+_T_activated\|Control / Disease, condition lineage and cell class	CERKL MMP24 ZNF37A DOCK9 SPTBN1 SYNE2 MACF1	5.83e-08	198	78	7	ee71543559836fd59adc0da877b2ca538cba60cb
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	MIA3 ZNF37A CFAP43 USP19 HNRNPU ANKS1A	4.75e-07	166	78	6	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CERKL ARMH2 NEK5 VWA3B CFAP43 CFAP61	8.40e-07	183	78	6	58847e8f3a7ce3e33adba9477bcd55e769a64a90
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CERKL NEK5 VWA3B CFAP43 CFAP61	1.53e-05	178	78	5	de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCell	droplet-Heart-nan-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE2 DNM3 NCK1 PEAK1 ITPR2	1.66e-05	181	78	5	92d44892bb15771f0ab5fe61879b204b0acbd9b3
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CERKL NEK5 VWA3B CFAP43 CFAP61	1.80e-05	184	78	5	5daff849625f2f41d56615569c0ed59cd733b34c
ToppCell	Adult-Epithelial-ciliated_cell-D175\|Adult / Lineage, Cell type, age group and donor	CERKL NEK5 VWA3B CFAP43 CFAP61	1.84e-05	185	78	5	30f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CERKL NEK5 VWA3B CFAP43 CFAP61	1.84e-05	185	78	5	3e39a3cb534dfe2301930f3e2f7e8cefb522c158
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	CERKL NEK5 VWA3B CFAP43 CFAP61	1.84e-05	185	78	5	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CERKL NEK5 VWA3B CFAP43 CFAP61	1.94e-05	187	78	5	9e10ed56090d82589bc457788282f664b70ace4b
ToppCell	Epithelial-ciliated_cell\|World / Lineage, Cell type, age group and donor	CERKL NEK5 VWA3B CFAP43 CFAP61	1.99e-05	188	78	5	61a459f3fe57e5728efc72637ff2edc2d343492b
ToppCell	Adult-Epithelial-ciliated_cell-D231\|Adult / Lineage, Cell type, age group and donor	CERKL NEK5 VWA3B CFAP43 CFAP61	1.99e-05	188	78	5	34b11f72ca73153d02edcd09b38983ad1a504659
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CERKL NEK5 VWA3B CFAP43 CFAP61	1.99e-05	188	78	5	2b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CERKL NEK5 VWA3B CFAP43 CFAP61	2.04e-05	189	78	5	68a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCell	COVID-19-Heart-EC_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC9C1 DOCK9 SPTBN1 SYNE2 PEAK1	2.04e-05	189	78	5	fe49852ba15f948b384d6b4c258927c70b741357
ToppCell	Adult-Epithelial-ciliated_cell\|Adult / Lineage, Cell type, age group and donor	CERKL NEK5 VWA3B CFAP43 CFAP61	2.04e-05	189	78	5	b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCell	COVID-19-lung-Ciliated\|lung / Disease (COVID-19 only), tissue and cell type	CERKL NEK5 VWA3B CFAP43 CFAP61	2.04e-05	189	78	5	27329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FAT1 SYNE2 PKHD1 DNM3 CFAP43	2.15e-05	191	78	5	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	ILEUM-non-inflamed-(6)_ILC3\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	MMP24 VWA3B SKIL IL23R CA2	2.15e-05	191	78	5	6eaf72b41084404bee0db04e4605db745a74995f
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UNC13B NEK5 SCN1A VWA3B CFAP43	2.26e-05	193	78	5	bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCell	Control-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	SLC9C1 NEK5 VWA3B CFAP43 CFAP61	2.32e-05	194	78	5	958e648138676d46698090b4046cb484083ae449
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	NEK5 SPTBN1 SYNE2 VWA3B CFAP43	2.37e-05	195	78	5	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	NEK5 SYNE2 VWA3B CFAP43 CFAP61	2.37e-05	195	78	5	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	NEK5 SPTBN1 SYNE2 VWA3B CFAP43	2.37e-05	195	78	5	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	(05)_Ciliated\|World / shred by cell type and Timepoint	CMBL RTP3 NEK5 CFAP43 CFAP61	2.49e-05	197	78	5	fee3cd16af8eea697cd64e8f64af505aaa2ac4b0
ToppCell	systemic_lupus_erythematosus-treated\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PSMA2 SYNE2 DGKZ SEPTIN7 HNRNPU	2.55e-05	198	78	5	8165ff735095c52994fb5057d89be93cc378b7da
ToppCell	systemic_lupus_erythematosus-flare\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PSMA2 SYNE2 MACF1 SEPTIN7 HNRNPU	2.55e-05	198	78	5	4c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL NEK5 VWA3B CFAP43 CFAP61	2.61e-05	199	78	5	2498237b9e895ca4826a3378d9d40989968df72b
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL NEK5 VWA3B CFAP43 CFAP61	2.61e-05	199	78	5	542ec45c931b40738df1f3777b00c83be33a514a
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DOCK9 SPTBN1 SYNE2 MACF1 DGKZ	2.68e-05	200	78	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL NEK5 VWA3B CFAP43 CFAP61	2.68e-05	200	78	5	52aef65f01b06cd98056f17977efe525aee6eb6f
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL NEK5 VWA3B CFAP43 CFAP61	2.68e-05	200	78	5	55c148238d5c80c1faa3428a917ae8075be2c145
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL NEK5 VWA3B CFAP43 CFAP61	2.68e-05	200	78	5	31d75c26055177d656df1fbb10b764cebd61e122
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL NEK5 VWA3B CFAP43 CFAP61	2.68e-05	200	78	5	926a7ea94b5908aebf103893ea83ce9d25285b65
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL NEK5 VWA3B CFAP43 CFAP61	2.68e-05	200	78	5	af6a551f83808c1c839df7ba7b1702ca28ea6e1b
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL NEK5 VWA3B CFAP43 CFAP61	2.68e-05	200	78	5	85c98da55f7cd4ffdf9d309b56c8cc5d43f3c04c
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL NEK5 VWA3B CFAP43 CFAP61	2.68e-05	200	78	5	e1dce91c6c531bb212002a14705e496d77ad3490
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL NEK5 VWA3B CFAP43 CFAP61	2.68e-05	200	78	5	73ac1cf40ddd764be1100cbfaaa29563665457d8
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL NEK5 VWA3B CFAP43 CFAP61	2.68e-05	200	78	5	12bc7d95c4166d12487081a76d210b7abe5991b0
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL NEK5 VWA3B CFAP43 CFAP61	2.68e-05	200	78	5	06ce6e03498ba38ef6a06eaf2731e3b2eeda59eb
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	BCLAF1 SYNE2 EIF5 MACF1 HNRNPU	2.68e-05	200	78	5	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	Ciliated_cells-B-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	CERKL NEK5 VWA3B CFAP43	1.36e-04	149	78	4	6399c5a2f06d79f020dece252526f1c0c110d569
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CERKL DHX32 CHD1L CA2	1.59e-04	155	78	4	d76a0f99ec35560d18820f9c92b69364ef2250e3
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	RALGAPA1 DOCK9 SYNE2 MACF1	1.62e-04	156	78	4	1545169694f686d28648a68b552c2ae606599d66
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	RALGAPA1 SPTBN1 SYNE2 MACF1	1.88e-04	162	78	4	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	Ciliated_cells-B-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	CERKL NEK5 VWA3B CFAP43	1.97e-04	164	78	4	0e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCell	Mild-MAIT\|World / Disease group and Cell class	MMP24 ABCA10 IL23R CA2	1.97e-04	164	78	4	21dc02997dfae73cf70ce291661928526605dba1
ToppCell	COVID-19_Mild-PLT_0\|COVID-19_Mild / Disease Group and Platelet Clusters	NEK5 SCN1A MACF1 CFAP43	2.01e-04	165	78	4	083a14d3b0162cee4e79f7398b8fb739582b39ff
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FAT1 TENM3 SYNE2 PKHD1	2.16e-04	168	78	4	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEK5 VWA3B CFAP43 CFAP61	2.21e-04	169	78	4	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	Ciliated_cells-A-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	NEK5 VWA3B CFAP43 CFAP61	2.26e-04	170	78	4	3d3a03979014df3a05c49be18010c6b94d786707
ToppCell	normal-na-Lymphocytic_T-T4_em-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	SYNE2 OSBPL8 LRATD2 MACF1	2.31e-04	171	78	4	61318a7aaf3bd8bdd28f8a8614ab4fdf2964b3a3
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	RALGAPA1 SYNE2 MACF1 HNRNPU	2.31e-04	171	78	4	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE6C NEK5 VWA3B CFAP43	2.41e-04	173	78	4	c3762655caa79ac4879876f470d32578a3c93b01
ToppCell	facs-Trachea-nan-24m-Mesenchymal-chondrocyte\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALX3 CMBL MMP24 PSMA8	2.41e-04	173	78	4	2226505610af1becc253d0a5550627144ef0ed6b
ToppCell	facs-Heart-RV-18m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RTP3 DOCK9 SPTBN1 DNM3	2.58e-04	176	78	4	fb3d03f64592e1df1d9785d9f2e70938d7ff9ce8
ToppCell	facs-Heart-RV-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RTP3 DOCK9 SPTBN1 DNM3	2.58e-04	176	78	4	3270a36fc91a5583646ffeb70bfcbc5af7292aac
ToppCell	facs-Heart-RV-18m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RTP3 DOCK9 SPTBN1 DNM3	2.58e-04	176	78	4	99410c121f55adbc7fcc013c8fa8905a45dba76b
ToppCell	Ciliated_cells-B-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	CERKL NEK5 VWA3B CFAP43	2.63e-04	177	78	4	c38138fb5ad9766c2d240811210c854338cd612e
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARMH2 KRT17 TENM3 BCAR3	2.69e-04	178	78	4	a107dd98a07086ed0429116095ecda60c9dbef1e
ToppCell	Ciliated_cells-A-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	ARMH2 NEK5 VWA3B CFAP43	2.69e-04	178	78	4	255473ee6df8a13079fb3bb61038162a40cb4c2c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENM3 NEK5 DVL2 CFAP43	2.69e-04	178	78	4	6178706db4a855d72abc156537604d575624df56
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FAT1 TENM3 SYNE2 PKHD1	2.69e-04	178	78	4	544379f5a6145429762258d426b876bb36c112f5
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENM3 NEK5 DVL2 CFAP43	2.69e-04	178	78	4	f02076ece0fa899e620971c887ad4da7f48684ed
ToppCell	normal-na-Lymphocytic_NK-T_mait-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	SYNE2 MACF1 SEPTIN7 IL23R	2.81e-04	180	78	4	e66a8a61b3576ac37de7c559d16d4ed4f7a2fc78
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARMH2 NEK5 VWA3B CFAP43	2.81e-04	180	78	4	92fb01b91261b3103454924cde56add337b41844
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_OPC-D\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KIAA0408 METTL21A NEK5 PRSS48	2.87e-04	181	78	4	493a0222923ea04dadf17927c208671a046cd6df
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CERKL VWA3B CFAP43 CFAP61	2.87e-04	181	78	4	dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCell	Adult-Epithelial-ciliated_cell-D122\|Adult / Lineage, Cell type, age group and donor	NEK5 VWA3B CFAP43 CFAP61	2.93e-04	182	78	4	7ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCell	Control-Epithelial_cells-Airway_ciliated\|Control / group, cell type (main and fine annotations)	NEK5 VWA3B CFAP43 CFAP61	2.93e-04	182	78	4	fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell	droplet-Heart-nan-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE2 DNM3 NCK1 ITPR2	2.93e-04	182	78	4	81279877b920b5a1bc991a07d3031d6458700fe3
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 FAT1 XIRP2 PKHD1	3.05e-04	184	78	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 FAT1 XIRP2 PKHD1	3.05e-04	184	78	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 FAT1 XIRP2 PKHD1	3.05e-04	184	78	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CERKL NEK5 VWA3B CFAP43	3.11e-04	185	78	4	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	COVID-19_Convalescent-PLT_4\|World / Disease Group and Platelet Clusters	RBSN XIRP2 EIF5 LRATD2	3.18e-04	186	78	4	5954a1e3ffafb33f2a9bc87af3343f304fda4c92
ToppCell	NS-critical-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CERKL NEK5 VWA3B CFAP43	3.18e-04	186	78	4	76033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell	tumor_Lung-Epithelial_cells-tS3\|Epithelial_cells / Location, Cell class and cell subclass	NEK5 VWA3B CFAP43 CFAP61	3.24e-04	187	78	4	3cea677279e71fdb9879530dea10a5e6393beacd
ToppCell	COPD-Epithelial-Ciliated\|COPD / Disease state, Lineage and Cell class	NEK5 VWA3B CFAP43 CFAP61	3.24e-04	187	78	4	f0fd0792f6926f705d175f6e6fd480f12c7a3bd4
ToppCell	Ciliated_cells-B-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	ARMH2 NEK5 VWA3B CFAP43	3.24e-04	187	78	4	6fa38dbccca36bc7a4fef46de74c6688f599f421
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RALGAPA1 BCLAF1 SYNE2 MACF1	3.31e-04	188	78	4	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	tumor_Lung-Epithelial_cells-tS3\|tumor_Lung / Location, Cell class and cell subclass	NEK5 VWA3B CFAP43 CFAP61	3.31e-04	188	78	4	26326b4e298e33f9ba393fc632238aa8c54b1ea3
ToppCell	Control-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	UNC13B FAT1 SPTBN1 CA2	3.31e-04	188	78	4	88b3415e33db81726dd29c1f50c886e057af50a0
ToppCell	ILEUM-inflamed-(1)_Cytotoxic_CD8_Trm\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	RALGAPA1 SYNE2 IL23R CA2	3.31e-04	188	78	4	d26894d1066a70e4b32ae41fff1c4718f2591ba9
ToppCell	COVID-19-lung-Ciliated\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CERKL NEK5 VWA3B CFAP43	3.38e-04	189	78	4	a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCell	Control-Epithelial-Ciliated\|Control / Disease state, Lineage and Cell class	NEK5 VWA3B CFAP43 CFAP61	3.38e-04	189	78	4	c007fccd08728db3ea99af9da91d67b9b16dabb3
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FAT1 SYNE2 PKHD1 CFAP43	3.38e-04	189	78	4	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FAT1 TENM3 SYNE2 PKHD1	3.38e-04	189	78	4	28b502611829e4a24caff2562545c7db97686099
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	NEK5 VWA3B CFAP43 CFAP61	3.38e-04	189	78	4	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CERKL SPTBN1 SYNE2 MACF1	3.44e-04	190	78	4	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN1 SYNE2 SEPTIN7 ITPR2	3.51e-04	191	78	4	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NEK5 VWA3B CFAP43 CFAP61	3.51e-04	191	78	4	e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NEK5 VWA3B CFAP43 CFAP61	3.51e-04	191	78	4	9d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN1 SYNE2 SEPTIN7 ITPR2	3.51e-04	191	78	4	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NEK5 VWA3B CFAP43 CFAP61	3.51e-04	191	78	4	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK9 SPTBN1 SYNE2 DNM3	3.58e-04	192	78	4	27ff3621e177e7932dd44dd6baa81551ea75a874
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIAA0408 FAT1 SCN1A CA2	3.58e-04	192	78	4	63d1b3efe93e5ff939278ebe40bacb38218ea09b
ToppCell	PBMC-Control-cDC_6\|Control / Compartment, Disease Groups and Clusters	BCLAF1 EIF5 OSBPL8 SEPTIN7	3.58e-04	192	78	4	41a7201febb7d88a39e4ee64df04cce18c691df8
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	RALGAPA1 DOCK9 SYNE2 MACF1	3.58e-04	192	78	4	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	IPF-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	NEK5 VWA3B CFAP43 CFAP61	3.58e-04	192	78	4	d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
Computational	Genes upregulated in subsets of cells of a given type within various tumors	FAT1 MACF1 PEAK1 HNRNPU	4.47e-05	50	43	4	GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_4
Drug	estradiol, USP; Down 200; 0.1uM; HL60; HT_HG-U133A	RALGAPA1 PDE6C BCAR3 SKIL UNC13A HNRNPU ITPR2	4.70e-06	197	77	7	2668_DN
Disease	Congenital muscular dystrophy (disorder)	SYNE2 DAG1	9.50e-05	6	75	2	C0699743
Disease	plasma renin activity measurement	TENM3 XIRP2	2.27e-04	9	75	2	EFO_0006828
Disease	coffee consumption measurement, insomnia	SUPT20H KRT17	2.83e-04	10	75	2	EFO_0004698, EFO_0006781
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	SYNE2 MACF1 SPG11 MADD	5.05e-04	144	75	4	EFO_0004611, EFO_0020943
Disease	platelet component distribution width	SUPT20H DOCK9 PRELID3B DNM3 MACF1 NCK1 SIN3A ANKS1A	6.60e-04	755	75	8	EFO_0007984
Disease	autoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis	TENM3 DAG1 IL23R	7.64e-04	70	75	3	EFO_0000384, EFO_0000676, EFO_0000729, EFO_0001060, EFO_0002609, EFO_0003898, EFO_0005140, EFO_0006812, MONDO_0005147, MONDO_0007915, MONDO_0015517
Disease	Child Behaviour Checklist assessment	PDE6C TENM3	9.50e-04	18	75	2	EFO_0005661
Disease	Intellectual Disability	RALGAPA1 SCN1A MACF1 SIN3A CA2 HNRNPU	9.75e-04	447	75	6	C3714756
Disease	Autism Spectrum Disorders	SCN1A SIN3A CA2	1.34e-03	85	75	3	C1510586
Disease	HDL cholesterol change measurement	SYNE2 ABCA10	1.70e-03	24	75	2	EFO_0007805
Disease	Squamous cell carcinoma of esophagus	FAT1 KRT17 CA2	1.85e-03	95	75	3	C0279626
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	SYNE2 MACF1 SPG11	2.32e-03	103	75	3	EFO_0008595, EFO_0020944

Protein segments in the cluster

Peptide	Gene	Start	Entry
HISVEIKGEEKVAPY	UNC13A	801	Q9UPW8
ISVYDKESPQVVHKA	CFAP43	456	Q8NDM7
AKHVVLSTDEIVPYD	CFAP61	751	Q8NHU2
EEEPVITASCLHKEY	ABCA10	1191	Q8WWZ4
LDPTVEYVKFSKERH	BCAR3	111	O75815
EELEKVFQKTHYPDV	ALX3	166	O95076
IPSAETYFHEEKIVV	ARMH2	46	H3BNL8
IVFYPATSKKEDAEH	ARFGEF2	1566	Q9Y6D5
TSTVEKIKIYTLEEH	ACOT12	371	Q8WYK0
DHIDKKYFPLTASEV	ANKS1A	421	Q92625
EVKNKHPVEVVYLSE	DHX32	236	Q7L7V1
DVKTTVVYPATEKHL	DCPS	126	Q96C86
VGETKVIYHLDEEET	DVL2	11	O14641
IDEKEHTPDIVKLYE	RBSN	266	Q9H1K0
EIPTKITIHEYDSIT	ITPR2	806	Q14571
AFDVVVEVTEEHKPS	FAT1	2046	Q14517
VPYHEIKSDRKEADI	MMP24	206	Q9Y5R2
EFVPEIKEVVSHKYK	MADD	1596	Q8WXG6
ELVEHYKKAPIFTSE	NCK1	351	P16333
DDPHKEEEIRKYSAI	NAB1	241	Q13506
PEKSSEDDVYLHTVI	DAG1	741	Q14118
KEEKNLVTEPTHYFI	FSIP2	6776	Q5CZC0
SIEHEVEAYKNFKPE	DNM3	306	Q9UQ16
ISHTYEEIETESKVP	PEAK1	661	Q9H792
TEEEAIKYVTVDPTK	PDE6C	696	P51160
EPEENSKISHKTYLV	NEK5	491	Q6P3R8
PVTDYEVLHKTRKEL	DNAH8	1261	Q96JB1
TEKIPVRHLYTKDID	HNRNPU	341	Q00839
SAKIIDLYHEKTIPE	KIAA0408	61	Q6ZU52
DLYHEKTIPEKVIES	KIAA0408	66	Q6ZU52
EKLTHLSYKEVPTAD	LRATD2	6	Q96KN1
HTPEKDKVVSAFYTI	OR2T35	266	Q8NGX2
VDKDVFSVETPKKEH	MACF1	2151	Q9UPN3
AKVVLTDPEAAKYVH	GBA	331	P04062
VEPLKETTYTEQSHE	OSBPL8	371	Q9BZF1
FTVRKVHYDPEKDVH	METTL21A	191	Q8WXB1
IEVVYSKAASVPKVE	EIF5	401	P55010
EDAHLTQYKKEPVTT	KRT17	391	Q04695
DKLPVHVYEVDEEVD	DOCK9	146	Q9BZ29
YVVERPSTTKDKHKE	BCLAF1	466	Q9NYF8
VATELPKKTEVVIYH	CHD1L	266	Q86WJ1
TKYVVHVKSLETEEE	IL23R	156	Q5VWK5
FVETYTVEEVKVHPR	CERKL	486	Q49MI3
EVTVETDKKTHYGLL	FAM114A2	226	Q9NRY5
YTDEPVSKILSHVEE	DGKZ	396	Q13574
SRPVKYEDVEHKVTT	MAP3K3	61	Q99759
TPRVHSIYKVEEVVK	RTP3	176	Q9BQQ7
ITVEKHPDADSLYVE	YARS1	376	P54577
TYVQEHSVVDPVEKT	PRELID3B	76	Q9Y3B1
YDHPEIAVTVKTKEE	SLC9C1	796	Q4G0N8
VPTVKKEHLDDYGEA	SKIL	46	P12757
AEEVKDKVPSLTTYE	SYNE2	2786	Q8WXH0
HEYTKEELQVPTDET	MIA3	106	Q5JRA6
IKTEYPEKEVTLIHS	AIFM2	161	Q9BRQ8
TYIREHSVVDPVEKK	PRELID3A	76	Q96N28
ESVHLETYPKERATE	SIN3A	526	Q96ST3
EKVESPAKIHVFYID	SND1	751	Q7KZF4
SSYEPHEAEVLTVKE	PKHD1	2901	P08F94
YDRVTKPIVEKHEQE	SCN1A	1986	P35498
KIHRAEVTEEFKDPS	SNAPC1	151	Q16533
ISVDHPDEKSIITYV	SPTBN1	256	Q01082
VDIDTHTAKYDPSLK	CA2	31	P00918
QVEHIKAYVTKSPVD	CMBL	26	Q96DG6
EKHEIIHSEEEPSEY	ZNF37A	106	P17032
DEYDVHENVPKVKES	SPG11	666	Q96JI7
YHEVTTVKKEEVIHG	XIRP2	1156	A4UGR9
EKGPDSVVVHVYVKE	USP19	291	O94966
PHYVVIKKDAETNEA	RALGAPA1	276	Q6GYQ0
QEHKIKIYEFPETDD	SEPTIN7	216	Q16181
SKPESKEEHAIYTAD	TINF2	301	Q9BSI4
AIPSEVDVEKYAKVE	SUPT20H	301	Q8NEM7
ENSEFVAYVKKEIPH	ZBED8	251	Q8IZ13
HTEYKELTAEPTIVA	THTPA	76	Q9BU02
YETIDKELIDHSPKA	NDUFB5	171	O43674
LYDERSVHKVEPITK	PSMA2	56	P25787
NPASKIHDVKDYITD	TENM3	2391	Q9P273
ISVEIKGEEKVAPYH	UNC13B	726	O14795
KIVIHPKYQDTTADV	PRSS48	101	Q7RTY5
RHEGVTEKEPKTYTT	ZNF280C	301	Q8ND82
YVPVLDKHVVSKVFD	VWA3B	876	Q502W6
SHKLTVEDPVTVEYI	PSMA8	101	Q8TAA3