Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionLIM domain binding

LDB2 LDB1

2.75e-059182GO:0030274
GeneOntologyMolecularFunctionpyridoxal phosphate binding

SPTLC3 MOCOS

1.15e-0356182GO:0030170
GeneOntologyMolecularFunctionvitamin B6 binding

SPTLC3 MOCOS

1.19e-0357182GO:0070279
GeneOntologyCellularComponentacrosomal vesicle

CRCP SEMG2 BSG

8.13e-04206193GO:0001669
DomainLIM-bd/SEUSS

LDB2 LDB1

8.77e-072182IPR029005
Domain-

SPTLC3 MOCOS

5.12e-04351823.90.1150.10
DomainPyrdxlP-dep_Trfase_major_sub2

SPTLC3 MOCOS

5.42e-0436182IPR015422
Domain-

SPTLC3 MOCOS

6.36e-04391823.40.640.10
DomainPyrdxlP-dep_Trfase

SPTLC3 MOCOS

7.04e-0441182IPR015424
DomainPyrdxlP-dep_Trfase_major_sub1

SPTLC3 MOCOS

7.04e-0441182IPR015421
Domain-

ZNF534 ZNF681 ZNF680 ZNF292

3.53e-036791843.30.160.60
Domainzf-C2H2

ZNF534 ZNF681 ZNF680 ZNF292

3.79e-03693184PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF534 ZNF681 ZNF680 ZNF292

3.81e-03694184IPR013087
DomainKRAB

ZNF534 ZNF681 ZNF680

4.60e-03358183PS50805
DomainKRAB

ZNF534 ZNF681 ZNF680

4.60e-03358183PF01352
DomainKRAB

ZNF534 ZNF681 ZNF680

5.01e-03369183SM00349
DomainKRAB

ZNF534 ZNF681 ZNF680

5.04e-03370183IPR001909
DomainZINC_FINGER_C2H2_2

ZNF534 ZNF681 ZNF680 ZNF292

5.65e-03775184PS50157
DomainZINC_FINGER_C2H2_1

ZNF534 ZNF681 ZNF680 ZNF292

5.70e-03777184PS00028
DomainZnf_C2H2-like

ZNF534 ZNF681 ZNF680 ZNF292

6.21e-03796184IPR015880
DomainZnf_C2H2

ZNF534 ZNF681 ZNF680 ZNF292

6.46e-03805184IPR007087
DomainZnF_C2H2

ZNF534 ZNF681 ZNF680 ZNF292

6.55e-03808184SM00355
Pubmed

Spliced isoforms of LIM-domain-binding protein (CLIM/NLI/Ldb) lacking the LIM-interaction domain.

LDB2 LDB1

3.14e-07220216815859
Pubmed

Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2.

LDB2 LDB1

3.14e-07220210083735
Pubmed

Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI.

LDB2 LDB1

3.14e-0722029799849
Pubmed

The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration.

LDB2 LDB1

9.42e-07320219675209
Pubmed

Cofactors of LIM Domains Associate with Estrogen Receptor α to Regulate the Expression of Noncoding RNA H19 and Corneal Epithelial Progenitor Cell Function.

LDB2 LDB1

9.42e-07320227129775
Pubmed

Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins.

LDB2 LDB1

9.42e-0732028918878
Pubmed

Isl1 and Ldb co-regulators of transcription are essential early determinants of mouse limb development.

LDB2 LDB1

3.14e-06520222411555
Pubmed

Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators.

LDB2 LDB1

3.14e-0652029860983
Pubmed

A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins.

LDB2 LDB1

4.71e-0662029192866
Pubmed

Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.

LDB2 LDB1

1.72e-051120211882901
Pubmed

Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells.

LDB2 LDB1

2.07e-051220217991461
Pubmed

Dynamic spatiotemporal expression of LIM genes and cofactors in the embryonic and postnatal cerebral cortex.

LDB2 LDB1

2.07e-051220212619132
Pubmed

RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.

LDB2 LDB1

2.07e-051220210431247
Pubmed

Tagging genes with cassette-exchange sites.

BSG TMEM131 ZNF681 ZNF292

3.63e-0533520415741177
Pubmed

LDB1 Is Required for the Early Development of the Dorsal Telencephalon and the Thalamus.

LDB2 LDB1

3.75e-051620230873428
Pubmed

LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem.

LDB2 LDB1

5.34e-051920211165475
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

UHRF2 LDB2 ZNF681 ZNF292 LDB1

7.75e-0580820520412781
Pubmed

LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth.

LDB2 LDB1

9.35e-052520219304889
Pubmed

The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis.

LDB2 LDB1

1.01e-042620227697904
Pubmed

Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation.

LDB2 LDB1

1.64e-043320226830346
Pubmed

Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor.

LDB2 LDB1

3.06e-044520223193182
Pubmed

Functional proteomics mapping of a human signaling pathway.

UHRF2 LDB2 LDB1 CCDC181

3.22e-0459120415231748
InteractionLMX1A interactions

LDB2 LDB1

3.77e-0510192int:LMX1A
InteractionLHX5 interactions

LDB2 LDB1

4.61e-0511192int:LHX5
Cytoband7q11.21

CRCP ZNF680

6.01e-04832027q11.21
CytobandEnsembl 112 genes in cytogenetic band chr7q11

CRCP ZNF680

6.15e-03271202chr7q11
CytobandEnsembl 112 genes in cytogenetic band chr20q13

FAM217B SEMG2

1.44e-02422202chr20q13
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF534 ZNF681 ZNF680 ZNF292

7.84e-057187428
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8|TCGA-Bladder / Sample_Type by Project: Shred V9

SRRM5 ZNF681 ZNF680

3.38e-051501931aa9320d97ff10994ea024751790524fe133aba9
ToppCellPND10-Epithelial-Epithelial_Airway-Basal-Basal-Basal_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SPTLC3 SERPINB12 MOCOS

5.26e-0517419397d4a40b536a67fa52f055eab26106d041bf3220
ToppCellPND10-Epithelial-Epithelial_Airway-Basal-Basal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SPTLC3 SERPINB12 MOCOS

5.26e-05174193f9f399244c7d12caf8118ec3117d477a39e35c3b
ToppCellPND10-Epithelial-Epithelial_Airway-Basal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SPTLC3 SERPINB12 MOCOS

5.26e-05174193e8440eea7c81864defa57c89e9b569ad8033e5c5
ToppCellDiffer-KC|World / shred by cell class for mouse tongue

BSG SERPINB12 MOCOS

6.52e-0518719308f70e5103c6dd96f439f0cceda878963d26850d
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-keratinocyte|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTLC3 SERPINB12 MOCOS

7.38e-05195193c54b19e31efe2c9ae690062569da7c0f1120a1d8
Diseasethird ventricle volume measurement

LDB2 LDB1

4.10e-0515192EFO_0010335
Diseaseeosinophil percentage of leukocytes

UHRF2 SERPINB12 TMEM131 ZNF292

1.16e-03746194EFO_0007991
DiseaseColorectal Carcinoma

UHRF2 ZNF292 LDB1

9.78e-03702193C0009402
Diseaseeosinophil count

UHRF2 SERPINB12 TMEM131 ZNF292

1.36e-021488194EFO_0004842

Protein segments in the cluster

PeptideGeneStartEntry
GGNTNNSNSKKKSPA

LDB1

311

Q86U70
NSKGGRKNKRANSSG

HECA

6

Q9UBI9
SAGNNANSTGSKKKT

LDB2

271

O43679
QHSKNSSGKRQSKSQ

FAM217B

11

Q9NTX9
KQSSNSQRNAKKKHG

MOCOS

706

Q96EN8
VNSDRSKGNGKSNHR

CCDC181

306

Q5TID7
KSSGQHQNDKGKNVR

BSG

366

P35613
QRKESGKNKHSSGQQ

CRCP

26

O75575
QNAKGKSGQSADSKQ

SEMG2

521

Q02383
NGKLHNHKKQSNGSQ

SPTLC3

11

Q9NUV7
KSNKQKAGSLNNESG

SERPINB12

76

Q96P63
KNGSSCKRTNGNIKH

UHRF2

166

Q96PU4
QKNLGSSKDSGGHKN

SPEM3

831

A0A1B0GUW6
QSRSHSKGKSQNQSR

SRRM5

331

B3KS81
AGRKSKGAKQSQHGS

TMEM131

1276

Q92545
NTGNKKGSHSNSRKN

ZNF292

2616

O60281
SSAGNKSLKNQHGLT

ZNF534

111

Q76KX8
GKAFNQSSNLTGHKK

ZNF681

596

Q96N22
FSNSNSHKKRNTGKK

ZNF680

166

Q8NEM1
QNSQSRQAKGHKSGQ

ULK4

316

Q96C45