Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainNUT

NUTM2B NUTM2A

2.01e-055272IPR024310
DomainNUT_N

NUTM2B NUTM2A

2.01e-055272IPR024309
DomainNUT

NUTM2B NUTM2A

2.01e-055272PF12881
DomainPROTEIN_KINASE_TYR

DDR1 LMTK3

8.61e-0397272PS00109
Pubmed

NUTM2A-CIC fusion small round cell sarcoma: a genetically distinct variant of CIC-rearranged sarcoma.

CIC NUTM2A

7.19e-07230228188754
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

RELB PRR14 LMTK3 CIC VASP SYNGAP1

1.59e-0643030635044719
Pubmed

The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.

NUTM2B NUTM2A

2.16e-06330222456610
Pubmed

The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.

NUTM2E NUTM2B

2.16e-06330226542179
Pubmed

Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.

NPC1 CGAS

7.18e-06530234290407
Pubmed

IRF3 and type I interferons fuel a fatal response to myocardial infarction.

TICAM1 CGAS

1.08e-05630229106401
Pubmed

STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus.

TICAM1 CGAS

1.08e-05630231249303
Pubmed

De novo gene disruptions in children on the autistic spectrum.

LMTK3 CIC

1.08e-05630222542183
Pubmed

The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis.

TICAM1 CGAS

1.51e-05730235545033
Pubmed

The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake.

TICAM1 CGAS

2.01e-05830233979578
Pubmed

Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection.

TICAM1 CGAS

2.58e-05930230923196
Pubmed

Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF.

RELB TICAM1

2.58e-05930234529751
Pubmed

Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.

RELB ADCY6

3.94e-051130211299302
Pubmed

Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner.

TICAM1 CGAS

4.72e-051230229632368
Pubmed

Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway.

TICAM1 CGAS

4.72e-051230224743339
Pubmed

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.

LMTK3 CIC

6.50e-051430228263302
Pubmed

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.

TICAM1 CGAS

7.50e-051530229056340
Pubmed

Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality.

TICAM1 CGAS

8.57e-051630227793594
Pubmed

Brg1 determines urothelial cell fate during ureter development.

SMARCA4 UPK3B

8.57e-051630223449535
Pubmed

Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies.

PAX1 ARL13B

8.57e-051630222228095
Pubmed

Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.

TICAM1 CGAS

1.35e-042030232150572
Pubmed

Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling.

ADCY6 ARL13B

1.35e-042030232702291
Pubmed

Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.

SMARCA4 RELB

1.50e-042130220460684
Pubmed

IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.

TICAM1 CGAS

1.80e-042330229576451
Pubmed

Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor.

TICAM1 CGAS

1.96e-042430234526512
Pubmed

Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation.

SMARCA4 RELB

2.68e-042830230037996
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NPC1 RELB HES2 INF2 CIC KCNH3

3.13e-04110530635748872
Pubmed

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.

SMARCA4 RELB INF2

3.61e-0416130332572027
Pubmed

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

DDR1 PSORS1C2 SYNGAP1

4.60e-0417530319851445
Pubmed

Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.

SMARCA4 SYNGAP1

6.35e-044330236950384
CytobandEnsembl 112 genes in cytogenetic band chr10q22

NUTM2E C10orf55 NUTM2B

3.40e-04208303chr10q22
Cytoband10q22.3

NUTM2E NUTM2B

3.67e-044330210q22.3
Cytoband6p21.3

DDR1 PSORS1C2 SYNGAP1

5.81e-042503036p21.3
CytobandEnsembl 112 genes in cytogenetic band chr19q13

RELB LMTK3 CIC VASP C19orf84

9.72e-041192305chr19q13
Cytoband19q13.32

RELB VASP

1.08e-037430219q13.32
CytobandEnsembl 112 genes in cytogenetic band chr6p21

DDR1 PSORS1C2 SYNGAP1

4.26e-03503303chr6p21
GeneFamilyReceptor Tyrosine Kinases|CD molecules

DDR1 LMTK3

5.62e-0440162321
ToppCelldroplet-Lung-LUNG-30m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDR1 RELB GRIN2C ADCY6

4.77e-061683040e8b0e6399c6c82c9c0e546f7316f902de0765d3
ToppCell15-Airway-Epithelial-Club-like_secretory|Airway / Age, Tissue, Lineage and Cell class

PAX1 PLSCR2 LMTK3 UPK3B

4.99e-061703041418031cc4b4a87a48621eb53a3c819cd713ddd0
ToppCellfacs-Brain_Non-Myeloid-Cortex|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 DDR1 GRIN2C GPR37

8.76e-06196304256fe9bc0815f66a9afe11ba3507ef1372b52fd3
ToppCellfacs-Aorta-Heart-24m-Endothelial-coronary_vascular_endothelial_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INF2 VASP TICAM1

1.80e-041643035ee3729fab794d7acb172d14ec5d91aa1a61cd61
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.3|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C10orf55 TICAM1 C19orf84

1.83e-0416530376abebe80e5f8bf44825bb619ae86fcb6f66ffeb
ToppCellPND10-Immune-Immune_Myeloid-DC-maDC-maDC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELB ADCY6 KCNH3

1.96e-04169303a83e4078db91ecedee637b28b12ec38640fe45f9
ToppCellPND10-Immune-Immune_Myeloid-DC-maDC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELB ADCY6 KCNH3

1.96e-04169303f914aa8899fa170a09da31e5fad86de897ea789b
ToppCellfacs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELB INF2 ADCY6

2.07e-0417230348d0cfc37d1b1ae48ed8f8b2711abeb609d2bb6e
ToppCell11.5-Airway-Epithelial-Basal_cell|Airway / Age, Tissue, Lineage and Cell class

DDR1 PAX1 LMTK3

2.07e-041723039d4d92e2d16dfc8a394f2641653bb97de20a2530
ToppCellfacs-Lung-EPCAM-18m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELB INF2 ADCY6

2.07e-041723037c085c02b59e24e2a2cd393b5e692f9fb19257fe
ToppCellfacs-Lung-EPCAM-18m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELB INF2 ADCY6

2.07e-04172303c5caae0b21e35a2d5dcd898fbfa1ef33f92c019f
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLSCR2 GRIN2C UPK3B

2.10e-041733033725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Tall_Cell|TCGA-Thryoid / Sample_Type by Project: Shred V9

NPC1 C10orf55 HES2

2.10e-041733032e9dc137f3675eee07f941eb4cfcaf24a83ab0fb
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLSCR2 GRIN2C UPK3B

2.10e-04173303ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCellAT1_cells-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

RELB TICAM1 ARL13B

2.10e-04173303b29816427428c7053017477f59b828bf1357f3b2
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)-|367C / Donor, Lineage, Cell class and subclass (all cells)

DDR1 PLSCR2 UPK3B

2.14e-04174303edf839d79ac58921f4e788f3b2cb2ae0d6af4b9e
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMARCA4 HES2 PSORS1C2

2.14e-04174303c2fc78dd6c440737ded59676961e4c7b923084ce
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMARCA4 HES2 PSORS1C2

2.14e-04174303021ebc6ec022b992d7b25333ba0b7416371e041b
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)|367C / Donor, Lineage, Cell class and subclass (all cells)

DDR1 PLSCR2 UPK3B

2.14e-0417430365539f69100db0b7d90b1b39ee15ab8281f86461
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELB GRIN2C ADCY6

2.17e-0417530391cb819a1786020713b7e64480de0545380daae9
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.4.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LMTK3 TICAM1 CGAS

2.21e-0417630323bde9b9b4977b8cfe7d2a3ab8e8088ce9c6012c
ToppCelldroplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELB GRIN2C ADCY6

2.25e-041773034672cc75225a4a23b298afa8ce439628262519db
ToppCellfacs-Heart-RA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDR1 ADCY6 VASP

2.48e-041833032f0dcc65ad4d90ef946919b4462280fdd20c5ea0
ToppCellfacs-Heart-RA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDR1 ADCY6 VASP

2.48e-041833030f02136359787bd78146617990968baa47a65d86
ToppCelldroplet-Limb_Muscle-nan-3m-Endothelial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLSCR2 ADCY6 PSORS1C2

2.72e-0418930316a4c92dd7a0d60f3691bd3130a091a9a54730f1
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DDR1 GRIN2C GPR37

2.77e-0419030307f21386ea6eb23416a537d2250e3042efe93fb0
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DDR1 LMTK3 KCNH3

2.85e-04192303dcf2d0c2e8868104c4dba410456207f0d947029a
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DDR1 LMTK3 KCNH3

2.85e-04192303a22952b885c8a7704a4a9602fa03e4f2c786bf75
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 DDR1 GPR37

3.12e-0419830343a2ce64fa309bac89a44ea320e87ae2cc39f782
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 DDR1 GPR37

3.12e-04198303a7e5de81eb7d3d23812c179a001adbaab1506596
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 DDR1 GPR37

3.12e-04198303731a90f7e68b19e387499d63e3979af78b503b0c
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 DDR1 GPR37

3.12e-0419830327f0654fb0857e93f030e1a4b1c307b31576bbcd
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 DDR1 GPR37

3.22e-0420030356f1f007ba8c9188a4b10e52744f1e50dc0f155a
DrugSKF 38393

RELB GRIN2C ADCY6 HRH3

1.12e-05110294CID000001242
DrugAC1O5LBK

NPC1 RELB CIC VASP KCNH3

1.25e-05242295CID006436256
Drug6-OHDA

RELB GRIN2C GPR37 ADCY6 HRH3

1.62e-05255295CID000004624
DrugLY 171555

RELB GRIN2C ADCY6 HRH3

3.05e-05142294CID000001257
DrugAC1L1EKQ

GRIN2C ADCY6 VASP

3.94e-0552293CID000002834
DiseaseEndometrial Stromal Sarcoma

NUTM2B NUTM2A

8.05e-065272C0206630
DiseaseClear cell sarcoma of kidney

NUTM2E NUTM2B

1.21e-056272C0334488
Diseaselevel of Sterol ester (27:1/18:1) in blood serum

SMARCA4 RELB

9.60e-0516272OBA_2045195
DiseaseSarcoma

SMARCA4 CIC

1.68e-0421272C1261473
Diseaselevel of Sterol ester (27:1/18:2) in blood serum

SMARCA4 RELB

2.59e-0426272OBA_2045194
Diseaselevel of Sterol ester (27:1/16:0) in blood serum

SMARCA4 RELB

2.59e-0426272OBA_2045191
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GRIN2C SYNGAP1

9.23e-0449272DOID:0060037 (implicated_via_orthology)
Diseaseintermediate density lipoprotein measurement

SMARCA4 RELB

2.88e-0387272EFO_0008595
Diseaseapolipoprotein B measurement

SMARCA4 RELB VASP PSORS1C2

2.94e-03663274EFO_0004615
Diseasecholesteryl ester measurement, intermediate density lipoprotein measurement

SMARCA4 RELB

3.35e-0394272EFO_0008595, EFO_0010351
Diseaselipid measurement, intermediate density lipoprotein measurement

SMARCA4 RELB

3.49e-0396272EFO_0004529, EFO_0008595
DiseaseHIV-1 infection

DDR1 PSORS1C2

3.63e-0398272EFO_0000180
Diseasephospholipid measurement, intermediate density lipoprotein measurement

SMARCA4 RELB

3.70e-0399272EFO_0004639, EFO_0008595
Diseasetotal cholesterol measurement, intermediate density lipoprotein measurement

SMARCA4 RELB

3.70e-0399272EFO_0004574, EFO_0008595
Diseasenon-high density lipoprotein cholesterol measurement

NPC1 SMARCA4 VASP PSORS1C2

3.81e-03713274EFO_0005689
Diseasecholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

SMARCA4 RELB

4.00e-03103272EFO_0008595, EFO_0020944
Diseasefree cholesterol measurement, intermediate density lipoprotein measurement

SMARCA4 RELB

4.08e-03104272EFO_0008591, EFO_0008595
Diseasefamilial hyperlipidemia

SMARCA4 RELB

4.23e-03106272MONDO_0001336
DiseaseOral ulcer

TICAM1 PSORS1C2

4.31e-03107272HP_0000155
Diseaseremnant cholesterol measurement

SMARCA4 RELB

4.39e-03108272EFO_0010815

Protein segments in the cluster

PeptideGeneStartEntry
EPPSPTPAGPPRCPW

ADCY6

51

O43306
PPAPWWPPGPPPTNF

DDR1

381

Q08345
GTEPWPPAPLPAPPP

C19orf84

21

I3L1E1
SPTPPPPPPPVGWGT

ARL13B

371

Q3SXY8
KPRPPPGPWDVPSPG

CGAS

131

Q8N884
GPVAPPATPPPWGCP

RELB

96

Q01201
PGPPPLMAPWPWGPP

KCNH3

966

Q9ULD8
PVPSPPSPPCGPGLW

HES2

156

Q9Y543
PPPPPPRDGPFPWPW

LMTK3

421

Q96Q04
GRPEGVPWMPAPPPP

PLSCR2

66

Q9NRY7
GWGPPPPPPPLLPCT

INF2

511

Q27J81
VCGPKPQPPPPPAPW

NPC1

246

O15118
PPWPPAQGPPLAPPG

PAX1

391

P15863
AAGPPGPPTRPPGPW

GPR37

106

O15354
PEAQPSPPPPPGCWG

HRH3

246

Q9Y5N1
GEGPLCYWPPPGSPP

RTL8C

21

O15255
GGWSQGLPLPPPPPP

NUTM2A

271

Q8IVF1
GGWSQGLPLPPPPPP

NUTM2B

271

A6NNL0
GGWSQGLPLPPPPPP

NUTM2E

271

B1AL46
GPGTCTWPPAPPQPS

PRR14

341

Q9BWN1
PPAPGVSWGPPPPGA

FBXL22

186

Q6P050
PPGGPPKPWPEGPMA

SMARCA4

276

P51532
PGWEGAPQPSPPPPG

CIC

1586

Q96RK0
PPLPPCPISWGESGP

C10orf55

126

Q5SWW7
LAPPWNGLAPPAPPP

SYNGAP1

1311

Q96PV0
GAPPPFPTWPGCPQP

TICAM1

616

Q8IUC6
PGPPPQPQPLAWPLC

UPK3B

296

Q9BT76
GGPPPPPALPTWSVP

VASP

116

P50552
PTLPQGPPVPGDPWP

PSORS1C2

41

Q9UIG4
GPPVPGDPWPGAPPL

PSORS1C2

46

Q9UIG4
PPPEPSPTGWGPPDG

GRIN2C

951

Q14957