Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K27 methyltransferase activity	JARID2 EHMT2	7.41e-05	6	45	2	GO:0046976
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	JARID2 SETD1B EHMT2	1.33e-04	44	45	3	GO:0140938
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	JARID2 SETD1B EHMT2	4.84e-04	68	45	3	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	JARID2 SETD1B EHMT2	5.05e-04	69	45	3	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	JARID2 SETD1B EHMT2	5.49e-04	71	45	3	GO:0042054
GeneOntologyMolecularFunction	G-protein beta/gamma-subunit complex binding	PLCB2 PIK3R5	1.44e-03	25	45	2	GO:0031683
GeneOntologyMolecularFunction	protein methyltransferase activity	JARID2 SETD1B EHMT2	1.62e-03	103	45	3	GO:0008276
GeneOntologyMolecularFunction	N-methyltransferase activity	JARID2 SETD1B EHMT2	1.71e-03	105	45	3	GO:0008170
GeneOntologyBiologicalProcess	chromatin organization	PAXIP1 NAP1L2 ZNF462 MYCN JARID2 SETD1B RAD54L2 EP400 YTHDC1 EHMT2	1.82e-05	896	45	10	GO:0006325
GeneOntologyBiologicalProcess	chromatin remodeling	PAXIP1 NAP1L2 MYCN JARID2 SETD1B RAD54L2 EP400 YTHDC1 EHMT2	2.63e-05	741	45	9	GO:0006338
GeneOntologyBiologicalProcess	protein-DNA complex organization	PAXIP1 NAP1L2 ZNF462 MYCN JARID2 SETD1B RAD54L2 EP400 YTHDC1 EHMT2	4.60e-05	999	45	10	GO:0071824
GeneOntologyCellularComponent	histone methyltransferase complex	PAXIP1 JARID2 SETD1B PELP1	2.04e-05	75	45	4	GO:0035097
GeneOntologyCellularComponent	methyltransferase complex	PAXIP1 JARID2 SETD1B PELP1	8.53e-05	108	45	4	GO:0034708
GeneOntologyCellularComponent	chromatin	NAP1L2 MYCN ZFHX2 JARID2 TIMELESS IRX6 ZEB1 EP400 PELP1 EHMT2 ZHX1	2.32e-04	1480	45	11	GO:0000785
GeneOntologyCellularComponent	transferase complex	PAXIP1 JARID2 CDK11A SETD1B EP400 DCAF8L1 PELP1 PIK3R5	9.31e-04	963	45	8	GO:1990234
Domain	Post-SET_dom	SETD1B EHMT2	6.67e-04	16	45	2	IPR003616
Domain	PostSET	SETD1B EHMT2	6.67e-04	16	45	2	SM00508
Domain	POST_SET	SETD1B EHMT2	6.67e-04	16	45	2	PS50868
Domain	Homeodomain-like	ZFHX2 IRX6 ZEB1 EP400 ZHX1	1.17e-03	332	45	5	IPR009057
Domain	Homeobox	ZFHX2 IRX6 ZEB1 ZHX1	2.39e-03	234	45	4	PF00046
Domain	HOMEOBOX_1	ZFHX2 IRX6 ZEB1 ZHX1	2.47e-03	236	45	4	PS00027
Domain	HOX	ZFHX2 IRX6 ZEB1 ZHX1	2.50e-03	237	45	4	SM00389
Domain	Homeobox_dom	ZFHX2 IRX6 ZEB1 ZHX1	2.58e-03	239	45	4	IPR001356
Domain	HOMEOBOX_2	ZFHX2 IRX6 ZEB1 ZHX1	2.58e-03	239	45	4	PS50071
Domain	SNF2_N	RAD54L2 EP400	2.69e-03	32	45	2	PF00176
Domain	SNF2_N	RAD54L2 EP400	2.69e-03	32	45	2	IPR000330
Domain	Znf_C2H2-like	ZNF462 ZFHX2 ZNF326 ZEB1 WIZ ZHX1 ZNF316	2.74e-03	796	45	7	IPR015880
Domain	Znf_C2H2	ZNF462 ZFHX2 ZNF326 ZEB1 WIZ ZHX1 ZNF316	2.92e-03	805	45	7	IPR007087
Domain	ZnF_C2H2	ZNF462 ZFHX2 ZNF326 ZEB1 WIZ ZHX1 ZNF316	2.98e-03	808	45	7	SM00355
Domain	SET	SETD1B EHMT2	4.38e-03	41	45	2	PF00856
Domain	-	ZFHX2 IRX6 ZEB1 ZHX1	4.72e-03	283	45	4	1.10.10.60
Domain	SET	SETD1B EHMT2	5.49e-03	46	45	2	SM00317
Domain	SET_dom	SETD1B EHMT2	6.46e-03	50	45	2	IPR001214
Domain	SET	SETD1B EHMT2	6.46e-03	50	45	2	PS50280
Domain	ZINC_FINGER_C2H2_2	ZNF462 ZFHX2 ZEB1 WIZ ZHX1 ZNF316	1.03e-02	775	45	6	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF462 ZFHX2 ZEB1 WIZ ZHX1 ZNF316	1.04e-02	777	45	6	PS00028
Domain	BBOX	TRIM63 TRIM26	1.20e-02	69	45	2	SM00336
Domain	-	TRIM63 TRIM26	1.27e-02	71	45	2	4.10.45.10
Domain	zf-B_box	TRIM63 TRIM26	1.30e-02	72	45	2	PF00643
Pubmed	Interaction network of human early embryonic transcription factors.	PAXIP1 ZNF462 ZEB1 RAD54L2 WIZ EP400 EHMT2 ZHX1	1.86e-08	351	46	8	38297188
Pubmed	Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex.	ZEB1 WIZ EHMT2	4.72e-07	12	46	3	17967884
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	PAXIP1 ZNF462 CDK11A RAD54L2 WIZ EP400	4.78e-07	222	46	6	37071664
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MYCN CDK11A TIMELESS PDE4C ZEB1 EP400 YTHDC1 ZHX1 CCDC9	6.74e-07	774	46	9	15302935
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	ZNF462 ZNF326 WIZ EP400 EHMT2	1.45e-06	146	46	5	23892456
Pubmed	Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.	ZNF462 JARID2 WIZ EHMT2	1.51e-06	63	46	4	25680957
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	MYCN CDK11A ZNF326 WIZ EP400 PELP1 YTHDC1 PHF23 WDR70	1.56e-06	857	46	9	25609649
Pubmed	Loss of circadian gene Timeless induces EMT and tumor progression in colorectal cancer via Zeb1-dependent mechanism.	TIMELESS ZEB1	1.71e-06	2	46	2	35034102
Pubmed	A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.	JARID2 WIZ EHMT2	1.74e-06	18	46	3	29628311
Pubmed	Human transcription factor protein interaction networks.	PAXIP1 ZNF462 CDK11A ZNF326 ZEB1 RAD54L2 WIZ EP400 EHMT2 PHF23 ZHX1	1.92e-06	1429	46	11	35140242
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	ZNF462 CDK11A EP400 PELP1 EHMT2 TRIM26	1.92e-06	282	46	6	23667531
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	ZNF462 JARID2 EP400 PELP1 YTHDC1 EHMT2 CCDC9	2.64e-06	469	46	7	27634302
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	PAXIP1 ZNF462 JARID2 SETD1B WIZ EHMT2 ZNF316	3.76e-06	495	46	7	27705803
Pubmed	KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m6A reader YTHDC1 protein degradation.	MYCN YTHDC1	5.13e-06	3	46	2	38745192
Pubmed	A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease.	SLC24A1 CNGB1	5.13e-06	3	46	2	26246500
Pubmed	Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma.	ZEB1 TRIM26	5.13e-06	3	46	2	33649471
Pubmed	The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression.	WIZ EHMT2	1.03e-05	4	46	2	25789554
Pubmed	Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.	WIZ EHMT2	1.71e-05	5	46	2	16702210
Pubmed	A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9.	JARID2 EHMT2	1.71e-05	5	46	2	19010785
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	ZNF326 WIZ PELP1 YTHDC1 TRIM26	2.03e-05	251	46	5	28077445
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	ZNF462 MYCN ZFHX2 JARID2 ZEB1	2.03e-05	251	46	5	29031500
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	JARID2 CDK11A ZNF326 WIZ UTP25 EP400 YTHDC1 EHMT2 ZHX1 TRIM26	2.09e-05	1497	46	10	31527615
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	ZEB1 RAD54L2 EP400 ZHX1 CCDC9 ZNF316	2.85e-05	453	46	6	29656893
Pubmed	LPCAT3 Is Transcriptionally Regulated by YAP/ZEB/EP300 and Collaborates with ACSL4 and YAP to Determine Ferroptosis Sensitivity.	ZEB1 EHMT2	3.58e-05	7	46	2	37166352
Pubmed	Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.	PAXIP1 EHMT2	3.58e-05	7	46	2	20670891
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	WIZ EP400 PELP1 EHMT2	4.71e-05	150	46	4	28242625
Pubmed	Interaction of ZEB and histone deacetylase with the PLDLS-binding cleft region of monomeric C-terminal binding protein 2.	ZEB1 EHMT2	4.77e-05	8	46	2	19754958
Pubmed	G9a coordinates with the RPA complex to promote DNA damage repair and cell survival.	WIZ EHMT2	4.77e-05	8	46	2	28698370
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	JARID2 SETD1B EP400 EHMT2	5.63e-05	157	46	4	30186101
Pubmed	ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.	JARID2 EHMT2	7.65e-05	10	46	2	20569692
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF462 MYCN JARID2 ZNF326 ZEB1 WIZ PHF23	8.66e-05	808	46	7	20412781
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	PAXIP1 ZNF326 RAD54L2 WIZ EP400 EHMT2	1.15e-04	583	46	6	29844126
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	CDK11A SETD1B RAD54L2 EP400 TRIM26 TPRN	1.20e-04	588	46	6	38580884
Pubmed	Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.	ZNF462 WIZ EHMT2	1.31e-04	74	46	3	29795351
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF462 TIMELESS WIZ EHMT2 ZHX1 WDR70	1.44e-04	608	46	6	36089195
Pubmed	Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.	ZNF462 WIZ EHMT2	1.48e-04	77	46	3	19505873
Pubmed	Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.	SETD1B EHMT2	1.78e-04	15	46	2	35907431
Pubmed	Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.	ZNF462 WIZ EHMT2	1.85e-04	83	46	3	20562864
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	PAXIP1 SETD1B	2.03e-04	16	46	2	24368734
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	RAD54L2 EP400 PHF23 TSPOAP1 ZHX1	2.55e-04	430	46	5	35044719
Pubmed	Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate.	WIZ EHMT2	2.88e-04	19	46	2	34150743
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	PAXIP1 SETD1B	3.20e-04	20	46	2	29785026
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	ZNF462 WIZ EHMT2	3.49e-04	103	46	3	32744500
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	RAD54L2 PELP1 TRIM26	3.80e-04	106	46	3	19394292
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	PAXIP1 SETD1B	3.89e-04	22	46	2	26886794
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZNF462 MYO15B EP400	3.90e-04	107	46	3	11347906
Pubmed	Genome-wide association study identifies five new schizophrenia loci.	PLCB2 TRIM26	4.25e-04	23	46	2	21926974
Pubmed	CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.	JARID2 EP400	4.25e-04	23	46	2	31281901
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	PAXIP1 EP400	4.25e-04	23	46	2	9225980
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	PAXIP1 WIZ EP400 EHMT2	4.36e-04	268	46	4	33640491
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	WIZ PELP1 EHMT2	4.94e-04	116	46	3	21549307
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	EP400 EHMT2 ZHX1	4.94e-04	116	46	3	30804394
Pubmed	P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma.	MYCN EP400	5.04e-04	25	46	2	36708875
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	CDK11A WIZ EP400 WDR70	5.35e-04	283	46	4	30585729
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PAXIP1 SETD1B WIZ EP400 WDR70 TMEM132A ZNF316	5.81e-04	1105	46	7	35748872
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	ZNF462 RAD54L2 EHMT2	6.15e-04	125	46	3	32891193
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	WIZ UTP25 EP400 EHMT2 TPRN WWC1 ZNF316	6.16e-04	1116	46	7	31753913
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	PAXIP1 SETD1B	7.77e-04	31	46	2	20516061
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	ZNF462 ZNF326 WIZ PELP1 YTHDC1 EHMT2	8.37e-04	847	46	6	35850772
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	ZNF326 PELP1 YTHDC1 TRIM26	9.49e-04	330	46	4	33301849
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZNF462 TIMELESS ZEB1 PELP1 YTHDC1 TMEM132A ZNF316	9.58e-04	1203	46	7	29180619
Pubmed	Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.	ZNF462 ZFHX2 WIZ EHMT2	9.70e-04	332	46	4	30595499
Pubmed	A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.	MYCN EP400	9.90e-04	35	46	2	20946988
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	NAP1L2 MYCN JARID2 TIMELESS IRX6 EHMT2	1.00e-03	877	46	6	20211142
Pubmed	G9a histone methyltransferase activity in retinal progenitors is essential for proper differentiation and survival of mouse retinal cells.	MYCN EHMT2	1.11e-03	37	46	2	23223288
Interaction	FEV interactions	PAXIP1 ZNF462 ZEB1 RAD54L2 WIZ EP400 EHMT2 ZHX1	1.45e-08	203	45	8	int:FEV
Interaction	CRX interactions	PAXIP1 ZNF462 IRX6 MYO15B WIZ EP400 EHMT2 ZHX1	8.22e-08	254	45	8	int:CRX
Interaction	CBX3 interactions	ZNF462 MYCN CDK11A ZEB1 AMER1 RAD54L2 WIZ EP400 EHMT2 WDR70 ZNF316	1.27e-07	646	45	11	int:CBX3
Interaction	PAX6 interactions	PAXIP1 ZNF462 PDE4C ZEB1 WIZ EP400 EHMT2 ZHX1	1.31e-06	366	45	8	int:PAX6
Interaction	HNF4A interactions	PAXIP1 ZNF462 RAD54L2 WIZ EP400 EHMT2 ZHX1	2.38e-06	275	45	7	int:HNF4A
Interaction	EN1 interactions	PAXIP1 ZEB1 WIZ UTP25 EP400	4.54e-06	110	45	5	int:EN1
Interaction	XAGE2 interactions	ZNF462 WIZ EHMT2	4.65e-06	15	45	3	int:XAGE2
Interaction	NUP43 interactions	ZNF462 TIMELESS SETD1B RAD54L2 EP400 PELP1 YTHDC1 ZHX1 ZNF316	8.18e-06	625	45	9	int:NUP43
Interaction	NANOG interactions	PAXIP1 ZNF462 JARID2 ZNF326 WIZ EP400 PELP1 EHMT2	9.86e-06	481	45	8	int:NANOG
Interaction	POLR1E interactions	PAXIP1 ZNF462 MYCN CDK11A WIZ UTP25 EHMT2	1.15e-05	350	45	7	int:POLR1E
Interaction	ZNF460 interactions	TRIM63 CDK11A UTP25 TRIM26 ZNF316	1.37e-05	138	45	5	int:ZNF460
Interaction	PHF19 interactions	MYCN JARID2 PELP1 YTHDC1	1.41e-05	66	45	4	int:PHF19
Interaction	ESRRB interactions	ZNF462 ZNF326 RAD54L2 WIZ EP400 EHMT2	2.43e-05	262	45	6	int:ESRRB
Interaction	HNRNPCL2 interactions	PLCB2 TIMELESS RAD54L2 YTHDC1 ZHX1 TRIM26	3.12e-05	274	45	6	int:HNRNPCL2
Interaction	EGR2 interactions	PAXIP1 ZNF462 RAD54L2 WIZ EP400	3.85e-05	171	45	5	int:EGR2
Interaction	NHLH1 interactions	ZEB1 WIZ EP400 EHMT2	4.41e-05	88	45	4	int:NHLH1
Interaction	TEAD1 interactions	PAXIP1 ZNF462 ZEB1 WIZ EHMT2	4.42e-05	176	45	5	int:TEAD1
Interaction	SP7 interactions	PAXIP1 MYCN CDK11A WIZ EP400 EHMT2	5.57e-05	304	45	6	int:SP7
Interaction	MYOD1 interactions	PAXIP1 ZEB1 WIZ EP400 EHMT2	7.02e-05	194	45	5	int:MYOD1
Interaction	KLF12 interactions	ZEB1 WIZ EP400 EHMT2 ZHX1	7.02e-05	194	45	5	int:KLF12
Interaction	PGGHG interactions	PAXIP1 YTHDC1	7.27e-05	6	45	2	int:PGGHG
Interaction	SNRNP40 interactions	ZNF462 MYCN ZNF326 WIZ EP400 PELP1 YTHDC1 ZNF316	7.31e-05	637	45	8	int:SNRNP40
Interaction	GATA2 interactions	PAXIP1 MYCN ZEB1 WIZ EHMT2	7.91e-05	199	45	5	int:GATA2
Interaction	CBX4 interactions	MYCN TRANK1 WIZ PELP1 EHMT2	9.10e-05	205	45	5	int:CBX4
Interaction	ARL6IP4 interactions	TRIM63 MYCN CCDC9 TMEM132A	1.02e-04	109	45	4	int:ARL6IP4
Interaction	RNF2 interactions	PAXIP1 MYCN CDK11A ZNF326 WIZ EP400 PELP1 EHMT2 TRIM26	1.05e-04	866	45	9	int:RNF2
Interaction	RBBP7 interactions	PAXIP1 ZNF462 JARID2 CDK11A EP400 PHF23 ZHX1	1.21e-04	507	45	7	int:RBBP7
Interaction	FOXK2 interactions	MYCN CDK11A SETD1B YTHDC1 PHF23	1.41e-04	225	45	5	int:FOXK2
Interaction	NFIX interactions	PAXIP1 ZEB1 WIZ EP400 EHMT2	1.47e-04	227	45	5	int:NFIX
Interaction	ELK3 interactions	WIZ EP400 EHMT2 ZHX1	1.48e-04	120	45	4	int:ELK3
Interaction	KLF3 interactions	ZEB1 WIZ EP400 EHMT2 ZHX1	1.50e-04	228	45	5	int:KLF3
Interaction	GAGE8 interactions	WIZ EHMT2	1.74e-04	9	45	2	int:GAGE8
Interaction	NOM1 interactions	PAXIP1 MYCN UTP25 YTHDC1	2.01e-04	130	45	4	int:NOM1
Interaction	COIL interactions	ZNF462 MYCN CDK11A MYO15B WIZ YTHDC1 EHMT2	2.05e-04	552	45	7	int:COIL
Interaction	ZNF653 interactions	TRIM63 UTP25 ZHX1	2.13e-04	52	45	3	int:ZNF653
Interaction	PRR3 interactions	MYCN ZNF326 YTHDC1 ZCRB1 ZNF316	2.13e-04	246	45	5	int:PRR3
Interaction	MYB interactions	PAXIP1 ZEB1 WIZ EHMT2	2.19e-04	133	45	4	int:MYB
Interaction	H3-3A interactions	MYCN TIMELESS SETD1B WIZ PELP1 EHMT2 ZHX1 WDR70	2.23e-04	749	45	8	int:H3-3A
Interaction	MAX interactions	MYCN WIZ EP400 PELP1 EHMT2	2.34e-04	251	45	5	int:MAX
Interaction	SLX4 interactions	PAXIP1 ZNF462 CDK11A RAD54L2 WIZ EP400 WDR70	2.54e-04	572	45	7	int:SLX4
Interaction	RBBP4 interactions	ZNF462 JARID2 CDK11A ZEB1 EHMT2 PHF23 ZHX1	2.57e-04	573	45	7	int:RBBP4
Interaction	KIAA0825 interactions	TRIM63 MYCN	2.65e-04	11	45	2	int:KIAA0825
Interaction	TLX2 interactions	PAXIP1 MYCN WIZ EHMT2	2.81e-04	142	45	4	int:TLX2
Interaction	LHX6 interactions	PAXIP1 ZEB1 EHMT2	2.95e-04	58	45	3	int:LHX6
Interaction	ABT1 interactions	MYCN ZEB1 AMER1 UTP25 ZCRB1 ZNF316	3.36e-04	423	45	6	int:ABT1
Interaction	SRSF7 interactions	PAXIP1 MYCN CDK11A ZNF326 YTHDC1 CCDC9	3.45e-04	425	45	6	int:SRSF7
Interaction	XAGE1B interactions	PAXIP1 TRIM63	3.74e-04	13	45	2	int:XAGE1B
Interaction	MEN1 interactions	PAXIP1 ZNF462 ZNF326 SETD1B WIZ EP400 PELP1 YTHDC1 EHMT2	3.83e-04	1029	45	9	int:MEN1
Interaction	PPIE interactions	TRIM63 MYCN ZNF326 YTHDC1 WDR70	4.00e-04	282	45	5	int:PPIE
Interaction	ELF2 interactions	MYCN ZEB1 EP400 EHMT2	4.02e-04	156	45	4	int:ELF2
Interaction	CSNK2B interactions	PAXIP1 CDK11A WIZ EP400 YTHDC1 EHMT2 ZHX1	4.34e-04	625	45	7	int:CSNK2B
Interaction	PRPF40A interactions	PAXIP1 MYCN CDK11A PELP1 ZHX1 CCDC9	4.45e-04	446	45	6	int:PRPF40A
Interaction	NKAPD1 interactions	MYCN MYO15B YTHDC1 CCDC9	4.53e-04	161	45	4	int:NKAPD1
Interaction	H3C2 interactions	TIMELESS WIZ EHMT2	4.71e-04	68	45	3	int:H3C2
Interaction	ZNF462 interactions	ZNF462 WIZ EHMT2	4.71e-04	68	45	3	int:ZNF462
Interaction	HCFC1 interactions	PAXIP1 MYCN SETD1B EP400 PELP1	4.76e-04	293	45	5	int:HCFC1
Interaction	SUZ12 interactions	PAXIP1 MYCN JARID2 ZNF326 EP400 YTHDC1 EHMT2	5.20e-04	644	45	7	int:SUZ12
Interaction	PNN interactions	MYCN CDK11A YTHDC1 CNGB1 CCDC9	5.47e-04	302	45	5	int:PNN
Interaction	HDAC2 interactions	MYCN JARID2 ZEB1 WIZ EP400 PELP1 EHMT2 ZHX1	5.86e-04	865	45	8	int:HDAC2
Interaction	FBXW11 interactions	ZNF326 AMER1 WIZ YTHDC1 WWC1 INKA1	6.07e-04	473	45	6	int:FBXW11
Interaction	TLX1 interactions	PAXIP1 ZNF462 WIZ EHMT2	6.20e-04	175	45	4	int:TLX1
Interaction	RPS6 interactions	MYCN ZEB1 WIZ UTP25 PELP1 TRIM26 WDR70 ZCRB1	6.27e-04	874	45	8	int:RPS6
Interaction	CNGA1 interactions	SLC24A1 WWC1	6.49e-04	17	45	2	int:CNGA1
Interaction	EHMT2 interactions	ZNF462 JARID2 ZEB1 WIZ EHMT2	6.61e-04	315	45	5	int:EHMT2
Interaction	POLR1G interactions	MYCN CDK11A WIZ EP400 PELP1 WDR70	7.22e-04	489	45	6	int:POLR1G
Interaction	DPRX interactions	RAD54L2 EHMT2	7.29e-04	18	45	2	int:DPRX
Interaction	LHX2 interactions	PAXIP1 WIZ EP400 EHMT2	7.33e-04	183	45	4	int:LHX2
Interaction	ZNF644 interactions	ZNF462 WIZ YTHDC1 EHMT2	7.79e-04	186	45	4	int:ZNF644
Interaction	GATA3 interactions	PAXIP1 TRIM63 MYCN WIZ	7.95e-04	187	45	4	int:GATA3
Interaction	KLF8 interactions	ZEB1 WIZ EP400 EHMT2 ZHX1	8.04e-04	329	45	5	int:KLF8
Interaction	HP1BP3 interactions	PAXIP1 MYCN ZNF326 WDR70 ZCRB1	8.04e-04	329	45	5	int:HP1BP3
Interaction	ELAVL2 interactions	MYCN ZNF326 YTHDC1 CCDC9	8.11e-04	188	45	4	int:ELAVL2
Interaction	EHMT1 interactions	ZNF462 JARID2 WIZ EHMT2	8.11e-04	188	45	4	int:EHMT1
Interaction	HNF1B interactions	PAXIP1 ZEB1 WIZ EP400	8.43e-04	190	45	4	int:HNF1B
Interaction	PRH1 interactions	WIZ EHMT2	9.03e-04	20	45	2	int:PRH1
Interaction	INKA1 interactions	TRIM63 INKA1	9.03e-04	20	45	2	int:INKA1
Interaction	HIRIP3 interactions	CDK11A EHMT2 CCDC9	9.67e-04	87	45	3	int:HIRIP3
Interaction	XAGE3 interactions	WIZ EHMT2	9.97e-04	21	45	2	int:XAGE3
Interaction	ZNF211 interactions	EHMT2 ZNF316	9.97e-04	21	45	2	int:ZNF211
Interaction	CDY2A interactions	WIZ EHMT2	9.97e-04	21	45	2	int:CDY2A
Interaction	TFAP2D interactions	MYCN ZEB1 RAD54L2	1.03e-03	89	45	3	int:TFAP2D
Interaction	RARRES1 interactions	WIZ EHMT2	1.09e-03	22	45	2	int:RARRES1
Interaction	ZNF518B interactions	WIZ EHMT2	1.09e-03	22	45	2	int:ZNF518B
Interaction	EZH1 interactions	JARID2 WIZ EHMT2	1.14e-03	92	45	3	int:EZH1
Interaction	PYHIN1 interactions	ZNF326 WIZ PELP1 YTHDC1 TRIM26	1.17e-03	358	45	5	int:PYHIN1
Interaction	CDYL2 interactions	WIZ EHMT2	1.20e-03	23	45	2	int:CDYL2
Interaction	ZMYND11 interactions	EP400 PELP1 ZHX1	1.21e-03	94	45	3	int:ZMYND11
Interaction	KHDRBS3 interactions	MYCN ZNF326 YTHDC1	1.21e-03	94	45	3	int:KHDRBS3
Interaction	NFIC interactions	PAXIP1 WIZ EHMT2 ZHX1	1.22e-03	210	45	4	int:NFIC
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZFHX2 ZEB1 ZHX1	2.26e-06	15	32	3	529
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF462 ZFHX2 ZNF326 ZEB1 WIZ ZHX1 ZNF316	2.14e-04	718	32	7	28
GeneFamily	Ataxins\|Trinucleotide repeat containing	PAXIP1 EP400	8.88e-04	25	32	2	775
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1B EHMT2	1.64e-03	34	32	2	487
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM63 TRIM26	1.22e-02	95	32	2	59
Coexpression	GSE45365_HEALTHY_VS_MCMV_INFECTION_CD11B_DC_UP	PDE4C SETD1B WIZ EP400 PELP1	1.60e-05	189	44	5	M9978
Coexpression	GSE31622_WT_VS_KLF3_KO_BCELL_DN	NAP1L2 TIMELESS UTP25 EHMT2 PIK3R5	2.10e-05	200	44	5	M8471
Coexpression	GSE3982_DC_VS_CENT_MEMORY_CD4_TCELL_DN	PAXIP1 NAP1L2 CDK11A ZEB1 TSPOAP1	2.10e-05	200	44	5	M5477
Disease	sex interaction measurement, ulcerative colitis	EHMT2 TRIM26	2.91e-04	17	44	2	EFO_0000729, EFO_0008343
Disease	Bilateral Wilms Tumor	MYCN AMER1	8.60e-04	29	44	2	C2930471
Disease	Neoplastic Cell Transformation	MYCN ZEB1 EHMT2	1.18e-03	139	44	3	C0007621
Disease	Nephroblastoma	MYCN AMER1	1.33e-03	36	44	2	C0027708
Disease	Takayasu arteritis	TRANK1 EHMT2 TRIM26	1.41e-03	148	44	3	EFO_1001857

Protein segments in the cluster

Peptide	Gene	Start	Entry
SEEELEEEEEEEEVE	ERICH6	21	Q7L0X2
EEEVEEEEEEVEEEE	ERICH6	31	Q7L0X2
EEEEEVEEEEEEVEE	ERICH6	36	Q7L0X2
VEEEEEEVEEEEEEV	ERICH6	41	Q7L0X2
EEVEEEEEEVVEEEL	ERICH6	46	Q7L0X2
DDEVDDEEETIEEEE	EP400	946	Q96L91
EEEEEEEVELEEEEE	AMER1	381	Q5JTC6
EQLSEEEEEEEEEEE	EHMT2	296	Q96KQ7
DVELEDAEEEEEEEE	RAD54L2	16	Q9Y4B4
DAEEEEEEEEVAVEE	RAD54L2	21	Q9Y4B4
SEEEEEVEDEEEEVE	CCER1	301	Q8TC90
EVEDEEEEVEDEEEE	CCER1	306	Q8TC90
EEEVEDEEEEEVEEA	CCER1	311	Q8TC90
DEEEEEVEEAEYVEE	CCER1	316	Q8TC90
AVEEEEEEEEEDDIE	NAP1L2	211	Q9ULW6
QEEEEEEEEEEEEEL	TSPOAP1	1261	O95153
EEEEEEEEAEDEEVV	IRX6	261	P78412
IIYEEEEEEEEEEEE	PAXIP1	186	Q6ZW49
EEEEEEEEEEVENEE	PAXIP1	191	Q6ZW49
EEEEEEEEAVVTEDR	INKA1	66	Q96EL1
EEEQEEEEEEEEQEE	SLC24A1	866	O60721
EAVAEEEEEEVEEEE	WWC1	851	Q8IX03
EEEEEVEEEEGEEDV	WWC1	856	Q8IX03
EEEELEEEEEEEEET	CFAP65	1771	Q6ZU64
EEEEEEEEETEEEEL	CFAP65	1776	Q6ZU64
ETSEEEEEEEEEEEE	PERCC1	31	A0A1W2PR82
TLEEAEEEDEEEEEE	PDE4C	661	Q08493
EEEEDEEEEEELEEV	PELP1	946	Q8IZL8
QEEEEEEEEEEEQEE	MYO15B	1001	Q96JP2
EEEEEEEQEEQEVET	MYO15B	1006	Q96JP2
DISEDEEEEEIEVEE	CCDC9	426	Q9Y3X0
EEEEEIEVEEGDEEE	CCDC9	431	Q9Y3X0
SEEEEEEEEEEEEET	CDK11A	311	Q9UQ88
EETEREEEEEEMEEE	DCAF8L1	96	A6NGE4
DEEEVEEEDDETEDV	JARID2	181	Q92833
NVSEEEEEDEEEEEE	UTP25	81	Q68CQ4
EEEDEEEEEEEDSIV	UTP25	86	Q68CQ4
EETEAREEEEEEEEE	TMEM132A	821	Q24JP5
QESTEEEEEAEEEEE	SETD1B	1071	Q9UPS6
EDEEEVVAREEEEEE	SETD1B	1176	Q9UPS6
SEEEEEEEEEEDVVL	WIZ	566	O95785
EEEEEEEEEEEVTEV	CNGB1	361	Q14028
TDEEEEEFIEEEDQE	TRIM63	326	Q969Q1
EEEEEEEEEEEEELQ	TIMELESS	666	Q9UNS1
ERGEEEEEVEEEEVE	ZFHX2	1706	Q9C0A1
EDDEEEDEEEEIDVV	MYCN	266	P04198
EEEEEEEEEVEEDLE	PIK3R5	321	Q8WYR1
LNEEEEEAEEEEEEE	WDR70	146	Q9NW82
EEEDEVIDDQEEDEE	ZHX1	836	Q9UKY1
DEEEEEEEEEEEVLE	TRIM26	421	Q12899
EEEEEEEEEEEMATV	PHF23	251	Q9BUL5
EEEGVEEDVEEDEEV	YTHDC1	201	Q96MU7
EEDVEEDEEVEEDAE	YTHDC1	206	Q96MU7
EDEEVEEDAEEDEEV	YTHDC1	211	Q96MU7
EGTELEEEEVEEEEE	PLCB2	501	Q00722
EEEEEEVEEEEVEEA	ZEB1	1066	P37275
EEEEEIVVEEEEEGV	ZNF316	46	A6NFI3
EEVDQQEEEEEEEEE	TPRN	601	Q4KMQ1
EEEIEEVEESEDEGE	ZCRB1	146	Q8TBF4
EDDEEEEEDNEVEIE	ZNF462	721	Q96JM2
EEEDEEEEDSIEVET	TRANK1	1091	O15050
EEEAEEVGEVEEVEE	ZNF326	506	Q5BKZ1
GEEEVEEEEEEENVE	AK7	421	Q96M32