Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cell adhesion molecule binding	JUP PTPRB PTPRJ CD40LG OBSCN ADAMTS5 ITGA4 FSCN1 LDHA CDH1	1.23e-04	599	79	10	GO:0050839
GeneOntologyMolecularFunction	L-lactate dehydrogenase activity	LDHA LDHC	1.53e-04	5	79	2	GO:0004459
GeneOntologyMolecularFunction	lactate dehydrogenase activity	LDHA LDHC	2.29e-04	6	79	2	GO:0004457
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	TH PAH	3.20e-04	7	79	2	GO:0016714
GeneOntologyMolecularFunction	cadherin binding	JUP PTPRB PTPRJ OBSCN FSCN1 LDHA CDH1	3.89e-04	339	79	7	GO:0045296
GeneOntologyMolecularFunction	sodium channel regulator activity	PRSS8 TMEM168 CAV3	7.02e-04	44	79	3	GO:0017080
GeneOntologyCellularComponent	receptor complex	CACNG2 PTPRB TIE1 ITGA4 IKBKB LRP1B CHRNA2 IL6ST GABBR1 GABRA3	7.30e-05	581	80	10	GO:0043235
Domain	Fascin	FSCN2 FSCN1	5.15e-05	3	78	2	PF06268
Domain	Fascin	FSCN2 FSCN1	5.15e-05	3	78	2	IPR010431
Domain	Fascin_metazoans	FSCN2 FSCN1	5.15e-05	3	78	2	IPR024703
Domain	Fascin-domain	FSCN2 FSCN1	5.15e-05	3	78	2	IPR022768
Domain	Biopterin_H	TH PAH	1.03e-04	4	78	2	PF00351
Domain	-	TH PAH	1.03e-04	4	78	2	1.10.800.10
Domain	Tyrosine_3-monooxygenase-like	TH PAH	1.03e-04	4	78	2	IPR019773
Domain	Aromatic-AA_hydroxylase_C	TH PAH	1.03e-04	4	78	2	IPR019774
Domain	ArAA_hydroxylase_Fe/CU_BS	TH PAH	1.03e-04	4	78	2	IPR018301
Domain	Actin_cross-linking	FSCN2 FSCN1	1.03e-04	4	78	2	IPR008999
Domain	BH4_AAA_HYDROXYL_2	TH PAH	1.03e-04	4	78	2	PS51410
Domain	ArAA_hydroxylase	TH PAH	1.03e-04	4	78	2	IPR001273
Domain	BH4_AAA_HYDROXYL_1	TH PAH	1.03e-04	4	78	2	PS00367
Domain	L-lactate_DH	LDHA LDHC	1.71e-04	5	78	2	IPR011304
Domain	L-lactate_DH_AS	LDHA LDHC	1.71e-04	5	78	2	IPR018177
Domain	L_LDH	LDHA LDHC	1.71e-04	5	78	2	PS00064
Domain	FN3_dom	PTPRB PTPRJ TIE1 OBSCN F3 IL6ST	2.40e-04	209	78	6	IPR003961
Domain	-	HPSE2 FUCA1 SLC3A1	4.17e-04	35	78	3	3.20.20.80
Domain	L-lactate/malate_DH	LDHA LDHC	4.74e-04	8	78	2	IPR001557
Domain	Ldh_1_N	LDHA LDHC	4.74e-04	8	78	2	PF00056
Domain	Lactate/malate_DH_N	LDHA LDHC	4.74e-04	8	78	2	IPR001236
Domain	ANF_lig-bd_rcpt	GUCY2C GRM4 GABBR1	4.92e-04	37	78	3	IPR001828
Domain	ANF_receptor	GUCY2C GRM4 GABBR1	4.92e-04	37	78	3	PF01094
Domain	Glyco_hydro_catalytic_dom	HPSE2 FUCA1 SLC3A1	5.32e-04	38	78	3	IPR013781
Domain	Peripla_BP_I	GUCY2C GRM4 GABBR1	5.75e-04	39	78	3	IPR028082
Domain	fn3	PTPRB PTPRJ TIE1 OBSCN IL6ST	5.85e-04	162	78	5	PF00041
Domain	-	LDHA LDHC	6.08e-04	9	78	2	3.90.110.10
Domain	Lactate/malate_DH_C	LDHA LDHC	6.08e-04	9	78	2	IPR022383
Domain	Lactate_DH/Glyco_Ohase_4_C	LDHA LDHC	6.08e-04	9	78	2	IPR015955
Domain	Ldh_1_C	LDHA LDHC	6.08e-04	9	78	2	PF02866
Domain	FN3	PTPRB PTPRJ TIE1 OBSCN IL6ST	1.06e-03	185	78	5	SM00060
Domain	FAD-dep_OxRdtase	DMGDH PCYOX1	1.11e-03	12	78	2	IPR006076
Domain	DAO	DMGDH PCYOX1	1.11e-03	12	78	2	PF01266
Domain	Glycoside_hydrolase_SF	HPSE2 FUCA1 SLC3A1	1.41e-03	53	78	3	IPR017853
Domain	FN3	PTPRB PTPRJ TIE1 OBSCN IL6ST	1.47e-03	199	78	5	PS50853
Domain	-	MAN2A1 FUCA1	1.52e-03	14	78	2	2.60.40.1180
Domain	Glyco_hydro_b	MAN2A1 FUCA1	1.75e-03	15	78	2	IPR013780
Domain	7tm_3	GRM4 GABBR1	3.77e-03	22	78	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	GRM4 GABBR1	3.77e-03	22	78	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM4 GABBR1	3.77e-03	22	78	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM4 GABBR1	3.77e-03	22	78	2	PS00979
Domain	G_PROTEIN_RECEP_F3_4	GRM4 GABBR1	3.77e-03	22	78	2	PS50259
Domain	GPCR_3_C	GRM4 GABBR1	3.77e-03	22	78	2	IPR017978
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	EPHX1 JUP MAN2A1 PTPRJ PGAP1 KDELR1 CACYBP BACE2 LRP1B PLBD2 IL6ST STT3B PCYOX1 COL1A1	5.72e-07	1201	80	14	35696571
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	JUP VPS13D PRSS8 MAN2A1 PTPRJ PIK3C2A SPON2 ESD FUCA1 LDHA SLC3A1 PCYOX1	3.51e-06	1016	80	12	19056867
Pubmed	CD148 tyrosine phosphatase promotes cadherin cell adhesion.	PTPRJ CDH1	5.23e-06	2	80	2	25386896
Pubmed	Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways.	TH PAH	5.23e-06	2	80	2	2872999
Pubmed	Prognostic significance of fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma.	FSCN1 CDH1	5.23e-06	2	80	2	19741544
Pubmed	Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A.	LDHA LDHC	5.23e-06	2	80	2	30590713
Pubmed	E3 Ubiquitin Ligase APC/CCdh1 Regulation of Phenylalanine Hydroxylase Stability and Function.	PAH CDH1	5.23e-06	2	80	2	33260674
Pubmed	Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.	JUP CDH1	5.23e-06	2	80	2	8207061
Pubmed	Reduced E-cadherin expression correlates with disease progression in Paget's disease of the vulva but not Paget's disease of the breast.	JUP CDH1	5.23e-06	2	80	2	18469796
Pubmed	CpG island hypermethylation of E-cadherin (CDH1) and integrin alpha4 is associated with recurrence of early stage esophageal squamous cell carcinoma.	ITGA4 CDH1	5.23e-06	2	80	2	18697202
Pubmed	Mutagenic insertion and chromosome engineering resource (MICER).	PGAP1 LRP1B	5.23e-06	2	80	2	15235602
Pubmed	Generation of an inducible mouse model to reversibly silence Stat3.	IL6ST COL1A1	5.23e-06	2	80	2	28170160
Pubmed	Human lactate dehydrogenase A (LDHA) rescues mouse Ldhc-null sperm function.	LDHA LDHC	5.23e-06	2	80	2	23467744
Pubmed	Abundance of repetitive sequence elements in the mouse testis-specific lactate dehydrogenase-C gene.	LDHA LDHC	5.23e-06	2	80	2	14581519
Pubmed	The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.	JUP CDH1	5.23e-06	2	80	2	10959047
Pubmed	Platelet-CD40 ligand interaction with melanoma cell and monocyte CD40 enhances cellular procoagulant activity.	CD40LG F3	5.23e-06	2	80	2	12192302
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	PTPRB TIE1 ARHGAP29 PCNX1 GRM4 SLC3A1 GABRA3 COL1A1	5.74e-06	420	80	8	28065597
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	ICOSLG PRSS8 MAN2A1 PTPRJ SPON2 ESD FUCA1 LDHA CDH1 LDHC PLBD2 IL6ST	5.94e-06	1070	80	12	23533145
Pubmed	Genetic predictors of fibrin D-dimer levels in healthy adults.	PTPRJ ARHGAP29 F3	6.42e-06	16	80	3	21502573
Pubmed	Beta-catenin is essential for pancreatic acinar but not islet development.	JUP CPA1 CDH1	7.79e-06	17	80	3	16192304
Pubmed	High expression of SALL4 and fascin, and loss of E-cadherin expression in undifferentiated/dedifferentiated carcinomas of the endometrium: An immunohistochemical and clinicopathologic study.	FSCN2 CDH1	1.57e-05	3	80	2	28272224
Pubmed	Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes.	JUP CDH1	1.57e-05	3	80	2	15023540
Pubmed	Differential expression of fascin, E-cadherin and vimentin: Proteins associated with survival of cholangiocarcinoma patients.	FSCN1 CDH1	1.57e-05	3	80	2	23221510
Pubmed	Collagen regulates the ability of endothelial progenitor cells to protect hypoxic myocardium through a mechanism involving miR-377/VE-PTP axis.	PTPRB COL1A1	1.57e-05	3	80	2	30044046
Pubmed	VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF.	JUP PTPRB	1.57e-05	3	80	2	19015309
Pubmed	A bone mineralization defect in the Pahenu2 model of classical phenylketonuria involves compromised mesenchymal stem cell differentiation.	PAH COL1A1	1.57e-05	3	80	2	30201326
Pubmed	Fascin1 is dispensable for mouse development but is favorable for neonatal survival.	FSCN2 FSCN1	1.57e-05	3	80	2	19343791
Pubmed	Beta-agonists enhance the lactic dehydrogenase (LDH) expression in serum and ventricular myocytes of mice.	LDHA LDHC	1.57e-05	3	80	2	17853776
Pubmed	Immunohistochemical expression of NEDD9, E-cadherin and γ-catenin and their prognostic significance in pancreatic ductal adenocarcinoma (PDAC).	JUP CDH1	1.57e-05	3	80	2	29924959
Pubmed	Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli.	LDHA LDHC	1.57e-05	3	80	2	1996957
Pubmed	Developmental regulation of expression of the lactate dehydrogenase (LDH) multigene family during mouse spermatogenesis.	LDHA LDHC	1.57e-05	3	80	2	2401207
Pubmed	Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation?	LDHA LDHC	1.57e-05	3	80	2	17178662
Pubmed	Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.	JUP CDH1	1.57e-05	3	80	2	1639850
Pubmed	Mesenchymal to Epithelial Transition Mediated by CDH1 Promotes Spontaneous Reprogramming of Male Germline Stem Cells to Pluripotency.	CDH1 COL1A1	1.57e-05	3	80	2	28065642
Pubmed	COL1A1, PRPF40A, and UCP2 correlate with hypoxia markers in non-small cell lung cancer.	PRPF40A COL1A1	1.57e-05	3	80	2	28258342
Pubmed	Association between serum lactate dehydrogenase and 60-day mortality in Chinese Hakka patients with acute myeloid leukemia: A cohort study.	LDHA LDHC	1.57e-05	3	80	2	34708888
Pubmed	Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice.	FSCN2 FSCN1	1.57e-05	3	80	2	25765874
Pubmed	Different stabilities and denaturation pathways for structurally related aromatic amino acid hydroxylases.	TH PAH	1.57e-05	3	80	2	15135070
Pubmed	Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes.	FSCN2 FSCN1	1.57e-05	3	80	2	10783262
Pubmed	Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL.	BCL2L1 COL1A1	1.57e-05	3	80	2	27048913
Pubmed	Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.	LDHA LDHC	1.57e-05	3	80	2	11276087
Pubmed	Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair.	MRC1 CDH1 COL1A1	2.29e-05	24	80	3	28237967
Pubmed	Protective effect of glutathione in HIV-1 lytic peptide 1-induced cell death in human neuronal cells.	LDHA LDHC	3.13e-05	4	80	2	11582518
Pubmed	Mesothelium of the murine allantois exhibits distinct regional properties.	ITGA4 CDH1	3.13e-05	4	80	2	21284019
Pubmed	Multiple post-translational modifications regulate E-cadherin transport during apoptosis.	JUP CDH1	3.13e-05	4	80	2	22375065
Pubmed	Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes.	JUP CDH1	3.13e-05	4	80	2	7876318
Pubmed	Direct role of plasma membrane-expressed gp120/41 in toxicity to human astrocytes induced by HIV-1-infected macrophages.	LDHA LDHC	3.13e-05	4	80	2	11125887
Pubmed	Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas.	JUP CDH1	3.13e-05	4	80	2	18837082
Pubmed	Plakoglobin is O-glycosylated close to the N-terminal destruction box.	JUP CDH1	3.13e-05	4	80	2	12847106
Pubmed	Expression of the E-cadherin-catenin complex in patients with pancreatic ductal adenocarcinoma.	JUP CDH1	3.13e-05	4	80	2	20529828
Pubmed	The expression of E-cadherin-catenin complex in patients with advanced gastric cancer: role in formation of metastasis.	JUP CDH1	3.13e-05	4	80	2	20529814
Pubmed	Cadherin and catenin expression in normal human bronchial epithelium and non-small cell lung cancer.	JUP CDH1	3.13e-05	4	80	2	10460003
Pubmed	Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion.	JUP CDH1	3.13e-05	4	80	2	7982500
Pubmed	hph-1: a mouse mutant with hereditary hyperphenylalaninemia induced by ethylnitrosourea mutagenesis.	ESD PAH	3.13e-05	4	80	2	3360305
Pubmed	Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland.	CDH1 COL1A1	3.13e-05	4	80	2	27340177
Pubmed	M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway.	MRC1 COL1A1	3.13e-05	4	80	2	24019537
Pubmed	Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation.	JUP CDH1	3.13e-05	4	80	2	8074697
Pubmed	The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin.	JUP CDH1	3.13e-05	4	80	2	11348595
Pubmed	Asymmetrical morphogenesis and medio-lateral positioning of molars during mouse development.	JUP CDH1	3.13e-05	4	80	2	11878758
Pubmed	Altered expression of cell adhesion molecules leads to differential uptake of hypericin in urothelial cancer.	JUP CDH1	3.13e-05	4	80	2	20933443
Pubmed	NF-κB signaling in fetal lung macrophages disrupts airway morphogenesis.	IKBKB CDH1	3.13e-05	4	80	2	21775686
Pubmed	Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking.	ITGA4 F3	3.13e-05	4	80	2	28495929
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	EPHX1 JUP FARSA MAP7D3 ARHGAP29 OCRL CACYBP PRPF40A STT3B	3.65e-05	708	80	9	39231216
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	JUP PTPRJ ARHGAP29 FSCN1 LDHA CDH1 IL6ST TPD52	4.80e-05	565	80	8	25468996
Pubmed	Sex differences in expression and subcellular localization of heart rhythm determinant proteins.	JUP CAV3	5.20e-05	5	80	2	21296051
Pubmed	Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton.	KDELR1 CDH1	5.20e-05	5	80	2	15084279
Pubmed	Defining the molecular basis of interaction between R3 receptor-type protein tyrosine phosphatases and VE-cadherin.	PTPRB PTPRJ	5.20e-05	5	80	2	28926625
Pubmed	Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions.	JUP CDH1	5.20e-05	5	80	2	10910767
Pubmed	The Mafb cleft-associated variant H131Q is not required for palatogenesis in the mouse.	ARHGAP29 CDH1	5.20e-05	5	80	2	33715275
Pubmed	The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin.	JUP CDH1	5.20e-05	5	80	2	7890674
Pubmed	The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.	JUP CDH1	5.20e-05	5	80	2	2788574
Pubmed	Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis.	CDH1 COL1A1	5.20e-05	5	80	2	31367040
Pubmed	Expression and interaction of different catenins in colorectal carcinoma cells.	JUP CDH1	5.20e-05	5	80	2	11712088
Pubmed	Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins.	BCL2L1 LDHA	5.20e-05	5	80	2	19838163
Pubmed	Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.	JUP CDH1	5.20e-05	5	80	2	2349235
Pubmed	Establishment of cadherin-based intercellular junctions in the dermal papilla of the developing hair follicle.	CDH1 COL1A1	5.20e-05	5	80	2	12524684
Pubmed	Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas.	CPA1 CDH1	5.20e-05	5	80	2	20807526
Pubmed	Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.	JUP CDH1	5.20e-05	5	80	2	7542250
Pubmed	The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin.	JUP CDH1	5.20e-05	5	80	2	7651399
Pubmed	Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.	LDHA LDHC	5.20e-05	5	80	2	21124955
Pubmed	Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes.	JUP CDH1	5.20e-05	5	80	2	10868478
Pubmed	Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro.	IL6ST COL1A1	5.20e-05	5	80	2	14617570
Pubmed	Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development.	ITGA4 ZDHHC17	5.20e-05	5	80	2	25478910
Pubmed	Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease.	ITGA4 CDH1	5.20e-05	5	80	2	34467254
Pubmed	Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme.	CDH1 COL1A1	5.20e-05	5	80	2	29290586
Pubmed	Polycystin: new aspects of structure, function, and regulation.	JUP CDH1	5.20e-05	5	80	2	11274246
Pubmed	Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells.	CD40LG BCL2L1	5.20e-05	5	80	2	23382671
Pubmed	ARHGAP29 Mutation Is Associated with Abnormal Oral Epithelial Adhesions.	ARHGAP29 CDH1	5.20e-05	5	80	2	28817352
Pubmed	Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation.	BCL2L1 IKBKB	5.20e-05	5	80	2	23332762
Pubmed	Impaired spleen formation perturbs morphogenesis of the gastric lobe of the pancreas.	CPA1 CDH1	5.20e-05	5	80	2	21738788
Pubmed	Live visualization of a functional RET-EGFP chimeric receptor in homozygous knock-in mice.	TH CDH1	5.20e-05	5	80	2	34324195
Pubmed	Mechanosignalling via integrins directs fate decisions of pancreatic progenitors.	CPA1 CDH1 COL1A1	5.54e-05	32	80	3	30487608
Pubmed	Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin.	ADAMTS5 CDH1 COL1A1	7.27e-05	35	80	3	16452166
Pubmed	Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth.	CPA1 CDH1	7.79e-05	6	80	2	20059954
Pubmed	Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer.	CDH1 COL1A1	7.79e-05	6	80	2	31771969
Pubmed	Lack of beta-catenin affects mouse development at gastrulation.	JUP CDH1	7.79e-05	6	80	2	8582267
Pubmed	The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites.	PTPRB PTPRJ	7.79e-05	6	80	2	26063811
Pubmed	Secreted heat shock protein 90α (HSP90α) induces nuclear factor-κB-mediated TCF12 protein expression to down-regulate E-cadherin and to enhance colorectal cancer cell migration and invasion.	IKBKB CDH1	7.79e-05	6	80	2	23386606
Pubmed	Localization of antigens associated with adherens junctions, desmosomes, and hemidesmosomes during murine molar morphogenesis.	JUP CDH1	7.79e-05	6	80	2	9615388
Pubmed	Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex.	JUP CDH1	7.79e-05	6	80	2	11226248
Cytoband	Ensembl 112 genes in cytogenetic band chrXq26	MAP7D3 CD40LG OCRL ADGRG4	2.36e-04	171	80	4	chrXq26
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	MRC1 ICOSLG PTPRJ CD40LG ITGA4 CDH1 F3 IL6ST	1.14e-05	394	50	8	471
GeneFamily	Fascins	FSCN2 FSCN1	2.24e-05	3	50	2	3
GeneFamily	Fibronectin type III domain containing	PTPRB PTPRJ TIE1 OBSCN IL6ST	7.83e-05	160	50	5	555
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRB PTPRJ	1.52e-03	21	50	2	813
Coexpression	ERWIN_COHEN_BLOOD_LIVE_VACCINE_TC_83_AGE_23_48YO_VACCINATED_VS_CONTROL_14DY_UP	MAN2A1 TMEM168 PIK3C2A TTC14 ITGA4 CACYBP TRIM22 PRPF40A IL6ST STT3B TPD52	6.64e-06	687	79	11	M41022
Coexpression	MURARO_PANCREAS_ALPHA_CELL	MRC1 MAP7D3 PGAP1 ELAPOR1 KDELR1 PCNX1 OCRL GRM4 TPD52 MTSS2	7.95e-06	568	79	10	M39168
Coexpression	LI_AMPLIFIED_IN_LUNG_CANCER	JUP KDELR1 FSCN1 LDHA CDH1 COL1A1	1.94e-05	183	79	6	M5792
Coexpression	GSE2826_WT_VS_XID_BCELL_UP	EPHX1 PTPRJ GUCY2C KDELR1 ARHGAP29 LDHC	3.20e-05	200	79	6	M4895
Coexpression	GSE17721_0.5H_VS_12H_CPG_BMDC_UP	EPHX1 MRC1 FUCA1 LDHA STT3B TPD52	3.20e-05	200	79	6	M4119
Coexpression	GSE38304_MYC_NEG_VS_POS_GC_BCELL_UP	EPHX1 PIK3C2A ARHGAP29 ZDHHC17 IL6ST STT3B	3.20e-05	200	79	6	M9273
Coexpression	AIZARANI_LIVER_C9_LSECS_1	MRC1 PTPRB MAP7D3 TIE1 ARHGAP29 FSCN1 IL6ST	3.74e-05	304	79	7	M39113
CoexpressionAtlas	facebase_RNAseq_e14.5_palate_poster_distal_ERK2_WT_2500_K4	EPHX1 MRC1 MAN2A1 ADAMTS5 ITGA4 ZNF804A IL6ST	1.42e-05	215	78	7	facebase_RNAseq_e14.5_palate_poster_distal_ERK2_WT_2500_K4
CoexpressionAtlas	gudmap_RNAseq_e15.5_Mesangium_2500_K4	TH SPON2 BACE2 CDH1 PCYOX1 TPD52	2.93e-05	162	78	6	gudmap_RNAseq_e15.5_Mesangium_2500_K4
ToppCell	EC-Sinusoidal_ECs\|World / Lineage and Cell class	MRC1 PTPRB TIE1 ARHGAP29 FSCN1 BACE2 IL6ST	5.06e-08	189	80	7	9a0956c8a7069ba3bd0fa56d052d6e514453e578
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	PTPRB TIE1 PIK3C2A ARHGAP29 BCL2L1 BACE2 IL6ST	5.84e-08	193	80	7	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	facs-Lung-nan-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 JUP PTPRB TIE1 ARHGAP29 LARS2 STT3B	6.27e-08	195	80	7	7f9b7f15006610ad591063d90e90367bd6083c7f
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB MAN2A1 TIE1 FSCN1 BACE2 IL6ST	6.72e-08	197	80	7	deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB MAN2A1 TIE1 FSCN1 BACE2 IL6ST	6.72e-08	197	80	7	a6aaa6faea348291023f0bc4b0f83fbc67d91da6
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB MAN2A1 TIE1 FSCN1 BACE2 IL6ST	6.96e-08	198	80	7	f0f1816a0ed3ae8207442602f5cbe4de0382e4b3
ToppCell	Control_saline-Endothelial-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	JUP PTPRB TIE1 ARHGAP29 ITGA4 FSCN1 TRIM22	7.45e-08	200	80	7	e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCell	Biopsy_IPF-Epithelial-KRT5-/KRT17+\|Biopsy_IPF / Sample group, Lineage and Cell type	JUP PRSS8 PLD5 FSCN1 CDH1 F3 COL1A1	7.45e-08	200	80	7	2fc7a3b3aea711ad3d96fd9513f4b40533056d86
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	JUP PTPRB TIE1 ARHGAP29 FSCN1 BACE2 TRIM22	7.45e-08	200	80	7	58a7ece7dfdf6c46f2a50cbcb580574dec14c748
ToppCell	Control_saline-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	JUP PTPRB TIE1 ARHGAP29 ITGA4 FSCN1 TRIM22	7.45e-08	200	80	7	3372c488a39fe812fa94e4f0564594186fea3db5
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ICOSLG MAN2A1 SPON2 OBSCN F3 COL1A1	5.93e-07	168	80	6	d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCell	Endothelial-B-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	ZNF676 TIE1 ARHGAP29 ADAMTS5 FSCN1 BACE2	7.03e-07	173	80	6	a81992965137195d20fc498f750975303961a828
ToppCell	COPD-Epithelial-Aberrant_Basaloid\|World / Disease state, Lineage and Cell class	JUP PLD5 BACE2 CDH1 F3 COL1A1	8.04e-07	177	80	6	22b7cda748cf5e665be54ca5bae89f0c130d5e7f
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	JUP PTPRB TIE1 FSCN2 ARHGAP29 FSCN1	8.04e-07	177	80	6	0e74980a7686c31fcf1476b8f19a3392541df240
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ICOSLG SPON2 ADAMTS5 BACE2 F3 COL1A1	8.87e-07	180	80	6	9adebde5f4ca6dcb90e9113622862e14298465ac
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB TIE1 IL6ST GABBR1 MTSS2	9.46e-07	182	80	6	b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ICOSLG SPON2 ADAMTS5 F3 GABRA3 COL1A1	1.07e-06	186	80	6	7c1807fca590cdccf7f5734460bac228d33964ca
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB TIE1 FSCN1 BACE2 IL6ST	1.25e-06	191	80	6	1924af7d8b0a0b892e480a9fd6d874941b0c0b5d
ToppCell	facs-Bladder-nan-18m-Epithelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX1 JUP FSCN1 BACE2 CDH1 TPD52	1.25e-06	191	80	6	b842647caf05d39f602de83c647d5c224715d19f
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB TIE1 FSCN1 BACE2 IL6ST	1.25e-06	191	80	6	88f91e57a1409bdeb91e9bf47510a6fb998a1bf5
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ICOSLG ADAMTS5 BACE2 F3 GABRA3 COL1A1	1.29e-06	192	80	6	7b48df661f61ce494bf6f0b9a74b0422e29c24bf
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JUP PTPRB TIE1 ARHGAP29 LARS2 STT3B	1.29e-06	192	80	6	4bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ICOSLG ADAMTS5 BACE2 F3 GABRA3 COL1A1	1.29e-06	192	80	6	32acd89617934016cd135d2cc797e8e79ae1b37f
ToppCell	(4)_Endothelial_cells\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	MRC1 PTPRB TIE1 ARHGAP29 ADAMTS5 IL6ST	1.33e-06	193	80	6	ae6ba13d4d9f2a700887cdda2790c32007b29ac8
ToppCell	RV-10._Endothelium_II\|RV / Chamber and Cluster_Paper	PTPRB TIE1 PIK3C2A ARHGAP29 BACE2 IL6ST	1.33e-06	193	80	6	01c2df9206f1527c578e808978e58196c35e72f5
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPON2 ADAMTS5 BACE2 F3 GABRA3 COL1A1	1.33e-06	193	80	6	858a186804b36d45957238d3d3eed2768b961641
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB TIE1 FSCN1 BACE2 IL6ST	1.33e-06	193	80	6	4a8c97ff2dffc5c06351d1cb107e21e58250aa55
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB TIE1 FSCN1 BACE2 IL6ST	1.33e-06	193	80	6	d5f6d6e2c36d4e80af4d39cdfc0b18df295a587b
ToppCell	EC-Sinusoidal_ECs\|EC / Lineage and Cell class	MRC1 ARHGAP29 ADAMTS5 FSCN1 BACE2 IL6ST	1.33e-06	193	80	6	1291b1d3494dcb4b9309f8bff63fb662e7eca0c8
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPON2 ADAMTS5 BACE2 F3 GABRA3 COL1A1	1.33e-06	193	80	6	7865e7ec0a288249540d4cba94ae01c93e1b617c
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPON2 ADAMTS5 BACE2 F3 GABRA3 COL1A1	1.33e-06	193	80	6	e27885a9e1a2a3e165c5366d4cfcda05c5454483
ToppCell	facs-Liver-Non-hepatocytes-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB TIE1 BACE2 LARS2 IL6ST	1.33e-06	193	80	6	8084fa0ce61f1f4a728423b6b81df04eaa5af5b6
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPON2 ADAMTS5 CAV3 F3 GABRA3 COL1A1	1.37e-06	194	80	6	ca1f24070424b44b7a442e4fca761ebfbe24b063
ToppCell	droplet-Liver-LIVER-NPC-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB TIE1 FSCN1 BACE2 IL6ST	1.41e-06	195	80	6	f55ab1018a6cde7d517b53e6ce44c3f7bde485c4
ToppCell	(0)_Normal/No_Treatment-(1)_VE-Cad+_vascular_cells\|(0)_Normal/No_Treatment / Stress and Cell class	MRC1 JUP TIE1 ARHGAP29 BACE2 IL6ST	1.41e-06	195	80	6	e8ab3122f81cb22920becd6611cbd9f00db19d50
ToppCell	droplet-Liver-LIVER-NPC-1m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB TIE1 FSCN1 BACE2 IL6ST	1.41e-06	195	80	6	ea1b00805391dca8be0883b635768b296369919a
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB TIE1 FSCN1 BACE2 IL6ST	1.41e-06	195	80	6	12ba6d95e42d06b1991b011043c0e3370a7b4131
ToppCell	droplet-Liver-LIVER-NPC-1m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB TIE1 FSCN1 BACE2 IL6ST	1.41e-06	195	80	6	126f46dd15dddcf5701144718bb8ba1ce84b2d1d
ToppCell	droplet-Liver-LIVER-NPC-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB TIE1 FSCN1 BACE2 IL6ST	1.41e-06	195	80	6	85df110f753f58ab017018c54ee454edb4428e29
ToppCell	Nasal_Brush-Epithelial-Goblet_1\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	PRSS8 ELAPOR1 ARHGAP29 LDHA F3 TPD52	1.46e-06	196	80	6	e16f0831f1f677b28e4a8014f0aede7e713d4f04
ToppCell	droplet-Liver-LIVER-NPC-1m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB TIE1 FSCN1 BACE2 IL6ST	1.46e-06	196	80	6	0dfa2dc1ec527d40005614c00ed0e5f3a566c2e2
ToppCell	critical-Epithelial-Secretory\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	EPHX1 ELAPOR1 BACE2 CDH1 F3 TPD52	1.46e-06	196	80	6	7da687eb983a54c28ee990424cc52e01caf5f4aa
ToppCell	droplet-Liver-LIVER-NPC\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB TIE1 FSCN1 BACE2 IL6ST	1.46e-06	196	80	6	a3513c91afdc2d363e1c57071ae2399f9b7e6263
ToppCell	Nasal_Brush-Epithelial-Goblet_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	PRSS8 ELAPOR1 ARHGAP29 LDHA F3 TPD52	1.46e-06	196	80	6	71e88d9ca28168732bd91f2d4f8f53bb4187963a
ToppCell	390C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	EPHX1 MRC1 JUP TIE1 ADAMTS5 FSCN1	1.50e-06	197	80	6	c84e988c2ad06087aafda9e3b68e9e72fd0e75f1
ToppCell	390C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	EPHX1 MRC1 JUP TIE1 ADAMTS5 FSCN1	1.50e-06	197	80	6	6195f945b3fd6da07907619267d49e96d1044f8f
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB TIE1 PIK3C2A ARHGAP29 FSCN1 IL6ST	1.59e-06	199	80	6	14e09eaa2335d4503de50250eb4258dd5b85b304
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PTPRB TIE1 PIK3C2A ARHGAP29 FSCN1 TRIM22	1.64e-06	200	80	6	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	JUP PTPRB TIE1 ARHGAP29 FSCN1 TRIM22	1.64e-06	200	80	6	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	Tracheal-10x5prime-Epithelial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	JUP PRSS8 ELAPOR1 CDH1 F3 TPD52	1.64e-06	200	80	6	efd461c687155c84ef590352207e6fe4ba392a90
ToppCell	Control_saline-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control_saline / Treatment groups by lineage, cell group, cell type	JUP TIE1 ARHGAP29 ITGA4 FSCN1 TRIM22	1.64e-06	200	80	6	041a34080120c9f613373c20dcc366292f558040
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_only / Treatment groups by lineage, cell group, cell type	JUP PTPRB TIE1 ARHGAP29 FSCN1 TRIM22	1.64e-06	200	80	6	b1fadb2b5e37e0f51e079d8409c2647eef68dc3b
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	JUP PTPRB TIE1 ARHGAP29 FSCN1 TRIM22	1.64e-06	200	80	6	f15fffefe372005c33e31845982e2d2714ac26af
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	JUP TIE1 ARHGAP29 FSCN1 BACE2 TRIM22	1.64e-06	200	80	6	89a6da2bdedc6b1ad0675c8753bf2b763a99af6a
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	LPIN1 VPS13D HPSE2 LRP1B GABBR1	1.07e-05	161	80	5	347edb0de10850b7d16c40945751033289289c9b
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)\|368C / Donor, Lineage, Cell class and subclass (all cells)	ZNF676 TIE1 ARHGAP29 ADAMTS5 FSCN1	1.31e-05	168	80	5	a74c8a9e3299183fba31ce3053ef325b5dbcd104
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	ZNF676 TIE1 ARHGAP29 ADAMTS5 FSCN1	1.31e-05	168	80	5	dae37b316ce80dfe4236c4ed7f0d4e7c340fa7b6
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTPRB TIE1 OBSCN PCNX1 BACE2	1.39e-05	170	80	5	af8b56555cbd5a1016ab9ec2ce88225c58c89648
ToppCell	COPD-Epithelial-Aberrant_Basaloid\|COPD / Disease state, Lineage and Cell class	JUP PLD5 CDH1 F3 COL1A1	1.64e-05	176	80	5	11d867bcb4f2471b4e13a5f7dc1c24286197f26d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L3-6_PVALB_MFI2_(Chandelier_2)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HPSE2 ZNF75CP PLD5 ADAMTS5 ZNF804A	1.69e-05	177	80	5	4f88ea4cfcfa8a9af5a14ab6f6be3b2aa015852e
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MRC1 PTPRB TIE1 ARHGAP29 UBE2U	1.78e-05	179	80	5	abc6797bd3884aa75dca58fcb2523ee321243ab1
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MRC1 PTPRB TIE1 ARHGAP29 UBE2U	1.78e-05	179	80	5	0b996d6e881f31e6b80d359f7caac70ecdeb9982
ToppCell	AT1-AT2_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SPON2 PLD5 ADAMTS5 FSCN1 COL1A1	1.83e-05	180	80	5	3c7b2033821f9e34e2924bd8655f566edcbcc7d3
ToppCell	Control-Epithelial-Goblet\|Control / Disease state, Lineage and Cell class	JUP ELAPOR1 BACE2 CDH1 F3	1.83e-05	180	80	5	5293d23b8b8ea587239ffde561b70bad01632521
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRRG1 PTPRB TIE1 ARHGAP29 BACE2	1.88e-05	181	80	5	4df7972f88117108698efd06b124b232f8588981
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	PPP1R10 MAN2A1 TTC14 IKBKB IL6ST	1.88e-05	181	80	5	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRRG1 PTPRB TIE1 ARHGAP29 BACE2	1.88e-05	181	80	5	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	droplet-Liver-Npc-21m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB TIE1 IL6ST GABBR1 MTSS2	1.93e-05	182	80	5	dc55de945c6f78f32eb3a1b3520835eb8417e068
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB TIE1 IL6ST GABBR1 MTSS2	1.93e-05	182	80	5	010a7364da46101cb5068891fd7bc712ea8f13bd
ToppCell	LA-11._Adipocyte\|World / Chamber and Cluster_Paper	LPIN1 HPSE2 F3 LRP1B ZNF804A	1.98e-05	183	80	5	b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCell	LA-11._Adipocyte\|LA / Chamber and Cluster_Paper	LPIN1 HPSE2 F3 LRP1B ZNF804A	1.98e-05	183	80	5	3f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-luminal_bladder_epithelial_cell_(umbrella_cell)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 PGAP1 BACE2 CDH1 PCYOX1	2.03e-05	184	80	5	382b1e90b3f437af596750669c0465a169d97095
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PTPRB BACE2 IL6ST MTSS2	2.09e-05	185	80	5	742350093d90f96735dc73e3360cdd749bae63fd
ToppCell	Control-Epithelial-Goblet\|World / Disease state, Lineage and Cell class	JUP ELAPOR1 BACE2 CDH1 F3	2.09e-05	185	80	5	9a793e6016295a63820e9d7563f195494ac692e7
ToppCell	ILEUM-inflamed-(7)_Lymphatics\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	EPHX1 JUP TIE1 ARHGAP29 UBE2U	2.09e-05	185	80	5	d711dd2e91cfee723dae1ccb2b910b8cf3becc3b
ToppCell	3'-Child09-12-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHX1 TIE1 ARHGAP29 FSCN1 UBE2U	2.09e-05	185	80	5	9de1db2ce9e44956b1214daf6e1e161334679c88
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D231\|Adult / Lineage, Cell type, age group and donor	PRRG1 PTPRB TIE1 ARHGAP29 FSCN1	2.09e-05	185	80	5	07f9f38f0739d7c830641723a38385550ac1ac92
ToppCell	3'-Child09-12-SmallIntestine-Endothelial-lymphatic_endothelial\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHX1 TIE1 ARHGAP29 FSCN1 UBE2U	2.09e-05	185	80	5	18f5d9438c76e37988a7d17aa2a080af6bedbfc4
ToppCell	Endoth-Lymph\|World / shred by cell class for parenchyma	MRC1 TIE1 ARHGAP29 ADAMTS5 FSCN1	2.09e-05	185	80	5	97a6c4cd00684d4085d36ef32f7dbb99563ed357
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Tcf7l2_(Entopeduncular_Nucleus_(Ent))--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	TH GUCY2C PTCH2 SLC3A1	2.11e-05	90	80	4	27865bd63dda0624e62a3b713464a490b588d3ae
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Tcf7l2_(Entopeduncular_Nucleus_(Ent))\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	TH GUCY2C PTCH2 SLC3A1	2.11e-05	90	80	4	8c2eb7444f938faade7c81a60c004252d588c80b
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Tcf7l2_(Entopeduncular_Nucleus_(Ent))-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	TH GUCY2C PTCH2 SLC3A1	2.11e-05	90	80	4	4bc53b521abb79fc53ac912f1dc2e3c55426b2e0
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB TIE1 ARHGAP29 BACE2 IL6ST	2.14e-05	186	80	5	41f1674afc17661eccaa779cdeb663db5e45685d
ToppCell	droplet-Lung-LUNG-30m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB TIE1 ARHGAP29 BACE2 IL6ST	2.14e-05	186	80	5	aa006650cf21a2c51dfe1091681f67fdad939107
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	PTPRB TIE1 PIK3C2A ARHGAP29 IL6ST	2.20e-05	187	80	5	7876dcb4800c2e54874df3d933efb79307a64a97
ToppCell	facs-Aorta-Heart-3m-Endothelial-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JUP PTPRB TIE1 ARHGAP29 BCL2L1	2.20e-05	187	80	5	df0279b7e94e26f5541b0e2a0ce56befa96ec8ca
ToppCell	Monocytes-M2-like_CD16+_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	EPHX1 MRC1 FUCA1 IKBKB FSCN1	2.20e-05	187	80	5	59e31c51183ed4c9a3d0792c8005ea3a12b28dfa
ToppCell	facs-Trachea-nan-3m-Epithelial-basal_epithelial_cell_of_tracheobronchial_tree\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 ELAPOR1 LARS2 CDH1 F3	2.20e-05	187	80	5	fe9fc21192ede2eea61f419d20ccda254569d0a6
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHX1 ELAPOR1 CDH1 F3 TPD52	2.25e-05	188	80	5	a6cbe58c5029acefbfbb64c3bff570de4e5e2449
ToppCell	myeloid-macrophage\|myeloid / Lineage and Cell class	EPHX1 MRC1 FUCA1 FSCN1 BACE2	2.31e-05	189	80	5	7c7dc5361250d6848c4050f8ef995561a0984a44
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	PTPRB PIK3C2A ARHGAP29 BACE2 IL6ST	2.31e-05	189	80	5	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	PTPRB TIE1 PIK3C2A ARHGAP29 IL6ST	2.31e-05	189	80	5	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	Control-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTPRB TIE1 FSCN1 BACE2 TRIM22	2.31e-05	189	80	5	5d7ae1ead7f4fbaeec26f651833c9c2106e1e4d1
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPON2 ADAMTS5 F3 GABRA3 COL1A1	2.31e-05	189	80	5	6b3b42d758b63a0df62310c34fa3bde421c1afd7
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPON2 ADAMTS5 F3 GABRA3 COL1A1	2.31e-05	189	80	5	344b23d3c47d0665dda1cd4856a5e72f1c28cfb3
ToppCell	P07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PTPRB PTPRJ TIE1 BACE2 IL6ST	2.37e-05	190	80	5	e1b721bb74561fe51c53328a0394c9954e489049
ToppCell	(2)_5-FU-(1)_VE-Cad+_vascular_cells\|World / Stress and Cell class	MRC1 JUP MAN2A1 TIE1 IL6ST	2.37e-05	190	80	5	6b391b8a3ffcbdec3acaf242bc52fc3fc9da77c8
ToppCell	21-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	MRC1 PTPRB TIE1 ARHGAP29 FSCN1	2.37e-05	190	80	5	bce09634acbc2cfd53666328e8aed8bf8835f845
ToppCell	P15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PTPRB MAN2A1 PTPRJ BACE2 IL6ST	2.37e-05	190	80	5	d072bb285bd34d518b958e7c9ad44739c60b359c
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JUP PTPRB TIE1 ARHGAP29 FSCN1	2.37e-05	190	80	5	c8370c922e0cf0e0c36e02e1ed2b4053ad6a8073
Drug	decoxymethanol	PTPRJ CD40LG HPSE2 ITGA4 LDHA LDHC	1.58e-07	70	79	6	CID004629337
Drug	Lancer	TIE1 PIK3C2A F3	1.39e-06	7	79	3	CID000040521
Drug	L-Phenylalanine	TH FARSA PAH	1.39e-06	7	79	3	DB00120
Drug	Dipyridamole	TH CD40LG BCL2L1 IKBKB COL1A1	2.08e-06	60	79	5	ctd:D004176
Drug	Nicorette	DMGDH TH PIK3C2A CD40LG BCL2L1 GRM4 F3 CHRNA2 IL6ST GABBR1 COL1A1	2.08e-06	529	79	11	CID000000942
Drug	UR-12633	LDHA F3 LDHC	2.22e-06	8	79	3	CID000128030
Drug	3-nitropropionic acid	TH PAH BCL2L1 ZDHHC17 LDHA PRPF40A LDHC	2.86e-06	178	79	7	CID000001678
Drug	latrunculin A	FSCN2 FSCN1 CDH1	4.74e-06	10	79	3	ctd:C037067
Drug	Hexestrol [84-16-2]; Down 200; 14.8uM; HL60; HT_HG-U133A	LPIN1 ICOSLG JUP VPS13D LARS2 TPD52 MTSS2	5.05e-06	194	79	7	2515_DN
Drug	Nalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; MCF7; HT_HG-U133A	PTCH2 PCNX1 HPSE2 ADAMTS5 CHRNA2 MTSS2 COL1A1	5.23e-06	195	79	7	2225_UP
Drug	Carbenoxolone disodium salt [7421-40-1]; Up 200; 6.6uM; HL60; HT_HG-U133A	ICOSLG PGAP1 KDELR1 PCNX1 BCL2L1 LARS2 IL6ST	5.59e-06	197	79	7	3014_UP
Drug	AC1L1KMJ	PTPRB PIK3C2A CAV3 ITGA4 IKBKB LDHA CDH1 LDHC TPD52 COL1A1	5.76e-06	476	79	10	CID000030956
Drug	Fursultiamine Hydrochloride [2105-43-3]; Up 200; 9.2uM; MCF7; HT_HG-U133A	VPS13D PCNX1 FSCN1 F3 ZNF783 MTSS2 COL1A1	5.78e-06	198	79	7	7349_UP
Drug	Isocarboxazid [59-63-2]; Down 200; 17.2uM; HL60; HT_HG-U133A	FAM120C OCRL FSCN1 ZNF783 SLC3A1 TPD52 COL1A1	5.97e-06	199	79	7	2562_DN
Drug	Paclitaxel	MRC1 TMEM168 PIK3C2A CD40LG BCL2L1 ADAMTS5 IKBKB FSCN1 LDHA F3 TPD52 COL1A1	6.72e-06	720	79	12	ctd:D017239
Drug	carvedilol	TH JUP BCL2L1 IKBKB F3 COL1A1	7.90e-06	136	79	6	ctd:C043211
Drug	phosphorothioate	CPA1 BCL2L1 ITGA4 IKBKB F3 PCYOX1 GABRA3 COL1A1	8.71e-06	296	79	8	CID000167253
Drug	Vincristine	EPHX1 PPP1R10 VPS13D MAN2A1 PIK3C2A ESD PCNX1 BCL2L1 ITGA4 LARP1B FSCN1 CDH1 F3 TRIM22 TPD52	1.16e-05	1182	79	15	ctd:D014750
Drug	oudenone	TH PAH	1.19e-05	2	79	2	CID000160199
Drug	amino N	PIK3C2A LDHA	1.19e-05	2	79	2	CID000193718
Drug	hydroxyl radicals	EPHX1 DMGDH TH PTPRB MAN2A1 PTPRJ GUCY2C ESD PGAP1 PAH CPA1 FUCA1 OCRL LRP1B PCYOX1 COL1A1	1.22e-05	1341	79	16	CID000000961
Drug	A26752	TH FARSA PAH	1.42e-05	14	79	3	CID000011479
Drug	Aminosweet	PAH BACE2 GRM4 STT3B	1.49e-05	43	79	4	CID000002242
Drug	N-methyl-DL-aspartic acid	CACNG2 TH PIK3C2A GUCY2C PAH ZDHHC17 GRM4 LDHA LDHC CHRNA2 GABRA3	1.57e-05	655	79	11	CID000004376
Drug	sodium	TH PRSS8 PTPRB GUCY2C CPA1 CAV3 LDHA F3 LDHC PLBD2 CHRNA2 SLC3A1 GABRA3	2.06e-05	944	79	13	CID000000923
Drug	Verteporfin [129497-78-5]; Down 200; 2.8uM; MCF7; HT_HG-U133A	EPHX1 PRRG1 MAN2A1 CDH1 IL6ST PCYOX1	2.07e-05	161	79	6	3556_DN
Drug	potassium citrate	LDHA LDHC SLC3A1	2.18e-05	16	79	3	CID000013344
Drug	tripotassium citrate monohydrate	LDHA LDHC SLC3A1	2.18e-05	16	79	3	CID002735208
Drug	vitamin E	PIK3C2A GUCY2C ZDHHC17 LDHA F3 LRP1B LDHC CHRNA2 COL1A1	2.19e-05	441	79	9	CID000002116
Drug	gossypol	TH PAH BCL2L1 ZDHHC17 LDHA PRPF40A LDHC	2.42e-05	247	79	7	CID000003503
Drug	acromelic acid A	GRM4 LDHA LDHC	3.16e-05	18	79	3	CID000108086
Drug	lithocholyltaurine	TH PAH ZDHHC17 LDHA PRPF40A LDHC	3.31e-05	175	79	6	CID000010595
Drug	DMPH2	TH PAH	3.56e-05	3	79	2	CID006453850
Drug	7,8-Dihydrobiopterin	TH PAH	3.56e-05	3	79	2	DB04400
Drug	BNPS-skatole	CPA1 FSCN1 LDHA LDHC	3.72e-05	54	79	4	CID000094388
Drug	quinolinic acid	TH PAH ZDHHC17 GRM4 PRPF40A IL6ST	3.75e-05	179	79	6	CID000001066
Drug	Papaverine hydrochloride [61-25-6]; Down 200; 10.6uM; HL60; HG-U133A	LPIN1 ICOSLG FARSA PCNX1 ITGA4 F3	3.99e-05	181	79	6	1755_DN
Drug	Mevalonic Acid	TH CD40LG BCL2L1 F3 COL1A1	4.25e-05	111	79	5	ctd:D008798
Drug	L-Phe-pro	IKBKB BACE2 F3 STT3B	4.30e-05	56	79	4	CID000162656
Drug	OOS-TMP	ESD LDHA LDHC	4.39e-05	20	79	3	CID000009039
Drug	17-isoprogesterone	LPIN1 TH GUCY2C HPSE2 BCL2L1 ITGA4 GRM4 LDHA F3 PRPF40A CHRNA2 IL6ST GABRA3 COL1A1	4.50e-05	1170	79	14	CID000004920
Drug	CTK8G2960	TH PAH ZDHHC17 IKBKB F3 PRPF40A	4.65e-05	186	79	6	CID005361912
Drug	Dicloxacillin sodium salt [13412-64-1]; Up 200; 8.2uM; MCF7; HT_HG-U133A	LPIN1 FARSA SPON2 PCNX1 IKBKB CDH1	4.79e-05	187	79	6	5012_UP
Drug	2-propylpentanoic acid; Up 200; 1000uM; MCF7; HT_HG-U133A_EA	LPIN1 PRSS8 PCNX1 MORC4 FSCN1 LARS2	4.79e-05	187	79	6	1047_UP
Drug	isoflurane	ICOSLG PIK3C2A GRM4 LDHA LDHC CHRNA2 GABRA3	5.25e-05	279	79	7	CID000003763
Drug	thiobarbituric acid	FARSA PIK3C2A SPON2 LDHA LDHC	5.70e-05	118	79	5	CID002723628
Drug	Prilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; MCF7; HT_HG-U133A	KDELR1 PCNX1 BCL2L1 FSCN1 CDH1 COL1A1	5.71e-05	193	79	6	3624_DN
Drug	Sulfamonomethoxine [1220-83-3]; Down 200; 14.2uM; HL60; HT_HG-U133A	LPIN1 ICOSLG VPS13D PCNX1 IL6ST COL1A1	5.87e-05	194	79	6	2742_DN
Drug	Zoxazolamine [61-80-3]; Down 200; 23.8uM; HL60; HT_HG-U133A	LPIN1 VPS13D MAP7D3 ITGA4 ZDHHC17 TPD52	6.04e-05	195	79	6	1270_DN
Drug	Molindone hydrochloride [15622-65-8]; Down 200; 12.8uM; PC3; HT_HG-U133A	PTPRB BCL2L1 FSCN1 GRM4 MTSS2 COL1A1	6.04e-05	195	79	6	4199_DN
Drug	Clorsulon [60200-06-8]; Down 200; 10.6uM; MCF7; HT_HG-U133A	ICOSLG VPS13D IKBKB FSCN1 IL6ST SLC3A1	6.04e-05	195	79	6	2884_DN
Drug	Meropenem [96036-03-2]; Down 200; 10.4uM; HL60; HT_HG-U133A	ICOSLG PGAP1 PCNX1 OCRL PCYOX1 COL1A1	6.22e-05	196	79	6	6141_DN
Drug	Nizatidine [76963-41-2]; Up 200; 12uM; PC3; HT_HG-U133A	TH VPS13D PCNX1 OCRL IKBKB MTSS2	6.22e-05	196	79	6	6305_UP
Drug	Phenformin hydrochloride [834-28-6]; Down 200; 16.6uM; MCF7; HT_HG-U133A	LPIN1 SPON2 PCNX1 FSCN1 F3 COL1A1	6.22e-05	196	79	6	2312_DN
Drug	Ethamsylate [2624-44-4]; Up 200; 15.2uM; MCF7; HT_HG-U133A	VPS13D PCNX1 IL6ST ZNF783 MTSS2 COL1A1	6.22e-05	196	79	6	7335_UP
Drug	Aminopurine, 6-benzyl [1214-39-7]; Down 200; 17.8uM; MCF7; HT_HG-U133A	ICOSLG VPS13D FSCN1 F3 ZNF783 COL1A1	6.22e-05	196	79	6	3623_DN
Drug	clozapine; Up 200; 10uM; MCF7; HT_HG-U133A	PRRG1 LPIN1 PGAP1 ZDHHC17 CHRNA2 MTSS2	6.40e-05	197	79	6	5589_UP
Drug	Metoclopramide monohydrochloride [7232-21-5]; Up 200; 11.8uM; HL60; HT_HG-U133A	ICOSLG JUP PTPRB SPON2 ZNF783 MTSS2	6.40e-05	197	79	6	2353_UP
Drug	16-phenyl tetranor Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	TH FAM120C PGAP1 OCRL CDH1 TPD52	6.40e-05	197	79	6	7505_UP
Drug	Altretamine [654-05-6]; Down 200; 19uM; PC3; HT_HG-U133A	PTPRB FAM120C IKBKB CDH1 MTSS2 COL1A1	6.58e-05	198	79	6	4627_DN
Drug	Cytisine (-) [485-35-8]; Down 200; 21uM; HL60; HG-U133A	VPS13D MAP7D3 PCNX1 OCRL F3 ZNF783	6.58e-05	198	79	6	1766_DN
Drug	2-propylpentanoic acid; Down 200; 50uM; HL60; HT_HG-U133A	FAM120C BCL2L1 ADAMTS5 FSCN1 ZNF783 MTSS2	6.76e-05	199	79	6	2682_DN
Drug	Halcinonide [3093-35-4]; Up 200; 8.8uM; MCF7; HT_HG-U133A	LPIN1 ICOSLG PTPRB CAV3 ITGA4 TRIM22	6.76e-05	199	79	6	6040_UP
Drug	Hesperetin [520-33-2]; Up 200; 13.2uM; MCF7; HT_HG-U133A	ICOSLG PGAP1 PCNX1 IKBKB CHRNA2 IL6ST	6.76e-05	199	79	6	1531_UP
Drug	SB 203580; Up 200; 1uM; PC3; HT_HG-U133A	PTPRB PCNX1 IKBKB TRIM22 LDHC CHRNA2	6.95e-05	200	79	6	6894_UP
Drug	Tetrahydrobiopterin	TH PAH	7.10e-05	4	79	2	DB00360
Drug	ox-Q	LDHA LDHC	7.10e-05	4	79	2	CID000448650
Drug	L75-4	TH PAH	7.10e-05	4	79	2	CID000151513
Drug	MK-801	TH FSCN1 GRM4 LDHA LDHC CHRNA2 GABRA3	7.62e-05	296	79	7	CID000001207
Drug	phorbol acetate myristate	CACNG2 PTPRJ TIE1 PIK3C2A ESD CD40LG HPSE2 BCL2L1 ITGA4 IKBKB FSCN1 CDH1 F3 IL6ST COL1A1	8.10e-05	1399	79	15	CID000004792
Drug	glycolic acid	HPSE2 LDHA LDHC COL1A1	8.22e-05	66	79	4	CID000000757
Drug	phenylalanine	TH FARSA PAH CPA1 F3 SLC3A1	8.63e-05	208	79	6	CID000000994
Drug	creatinine	PIK3C2A GUCY2C OCRL LDHA F3 LDHC COL1A1	8.64e-05	302	79	7	CID000000588
Drug	AC1L1FHZ	MRC1 TH PAH ZDHHC17 LDHA PRPF40A	1.04e-04	215	79	6	CID000003244
Drug	ethidium homodimer	BACE2 LDHA LDHC	1.11e-04	27	79	3	CID004072365
Drug	spirobishexahydropyrimidine	LDHA LDHC	1.18e-04	5	79	2	CID000100750
Drug	AC1O5TJF	LDHA LDHC	1.18e-04	5	79	2	CID006440410
Drug	1,4-diethoxybutane	LDHA LDHC	1.18e-04	5	79	2	CID000232578
Drug	C4H3NO4	LDHA LDHC	1.18e-04	5	79	2	CID000448651
Drug	S-lac-NAD	LDHA LDHC	1.18e-04	5	79	2	CID000194292
Drug	sorbarin	LDHA LDHC	1.18e-04	5	79	2	CID009824100
Drug	AC1O5ZB9	LDHA LDHC	1.18e-04	5	79	2	CID006443605
Drug	AC1L49DG	LDHA LDHC	1.18e-04	5	79	2	CID000152931
Drug	4-vinylcatechol	TH PAH	1.18e-04	5	79	2	CID000151398
Drug	N-trifluoroacetyl-glycine	LDHA LDHC	1.18e-04	5	79	2	CID000136227
Drug	acetylphosphonic acid	LDHA LDHC	1.18e-04	5	79	2	CID000081311
Drug	NSC-60195	LDHA LDHC	1.18e-04	5	79	2	CID000020481
Drug	ethyl gossypol	LDHA LDHC	1.18e-04	5	79	2	CID000374353
Drug	oxyayanin A	LDHA LDHC	1.18e-04	5	79	2	CID005281676
Drug	B-HAD	LDHA LDHC	1.18e-04	5	79	2	CID000131338
Drug	SQ 31,486	LDHA LDHC	1.18e-04	5	79	2	CID000130015
Drug	BMS-188107	LDHA LDHC	1.18e-04	5	79	2	CID000192297
Drug	APDC	PIK3C2A CD40LG BCL2L1 IKBKB FSCN1 GRM4 F3	1.19e-04	318	79	7	CID000065351
Drug	Hypertensin II	PIK3C2A CAV3 IKBKB BACE2 F3 LRP1B SLC3A1 COL1A1	1.21e-04	429	79	8	CID000025476
Drug	theaflavin	KDELR1 FUCA1 BCL2L1 IKBKB F3 IL6ST	1.30e-04	224	79	6	CID000114777
Drug	Sulfasalazine	EPHX1 IKBKB CDH1 F3 COL1A1	1.32e-04	141	79	5	ctd:D012460
Drug	borane (2	TH PAH BCL2L1 FSCN1	1.35e-04	75	79	4	CID000139760
Drug	17alpha-estradiol	TH PIK3C2A GUCY2C HPSE2 BCL2L1 CAV3 LDHA LRP1B LDHC CHRNA2 IL6ST TPD52 GABRA3 COL1A1	1.42e-04	1303	79	14	CID000000450
Drug	mazindol	TH PIK3C2A LDHA LDHC	1.42e-04	76	79	4	CID000004020
Drug	zoledronic acid	LPIN1 ICOSLG MAP7D3 PIK3C2A CD40LG ARHGAP29 PLD5 FUCA1 BCL2L1 FSCN1 F3 TRIM22 SLC3A1 PCYOX1 COL1A1	1.43e-04	1472	79	15	ctd:C088658
Disease	diabetes mellitus (is_marker_for)	CD40LG FUCA1 CDH1 F3	4.47e-06	41	79	4	DOID:9351 (is_marker_for)
Disease	Myoglobinuria	LPIN1 LDHA	7.08e-06	2	79	2	C0027080
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	EPHX1 PTPRJ CDH1	1.74e-05	19	79	3	C1333991
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	EPHX1 PTPRJ CDH1	1.74e-05	19	79	3	C2936783
Disease	Prostatic Neoplasms	EPHX1 JUP PRSS8 SPON2 KDELR1 CDH1 LRP1B IL6ST TPD52	3.99e-05	616	79	9	C0033578
Disease	Malignant neoplasm of prostate	EPHX1 JUP PRSS8 SPON2 KDELR1 CDH1 LRP1B IL6ST TPD52	3.99e-05	616	79	9	C0376358
Disease	thrombosis (is_marker_for)	CD40LG F3	4.23e-05	4	79	2	DOID:0060903 (is_marker_for)
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	EPHX1 PTPRJ CDH1	4.59e-05	26	79	3	C0009405
Disease	Hereditary non-polyposis colorectal cancer syndrome	EPHX1 PTPRJ CDH1	5.16e-05	27	79	3	C1112155
Disease	Hereditary Nonpolyposis Colorectal Cancer	EPHX1 PTPRJ CDH1	6.42e-05	29	79	3	C1333990
Disease	D dimer measurement	PTPRJ ARHGAP29 F3	7.12e-05	30	79	3	EFO_0004507
Disease	familial hyperlipidemia (is_marker_for)	CD40LG F3	1.05e-04	6	79	2	DOID:1168 (is_marker_for)
Disease	Cleft palate with cleft lip	ARHGAP29 CDH1	2.52e-04	9	79	2	C0158646
Disease	Bipolar Disorder	TH GRM4 LDHA LARS2 ZNF804A CHRNA2 GABRA3	2.94e-04	477	79	7	C0005586
Disease	pneumonia (implicated_via_orthology)	ITGA4 IKBKB	3.14e-04	10	79	2	DOID:552 (implicated_via_orthology)
Disease	hypertension (biomarker_via_orthology)	TH IKBKB LDHA F3 GABBR1	3.66e-04	227	79	5	DOID:10763 (biomarker_via_orthology)
Disease	Pneumonia	CD40LG IKBKB IL6ST	4.15e-04	54	79	3	C0032285
Disease	Lobar Pneumonia	CD40LG IKBKB IL6ST	4.15e-04	54	79	3	C0032300
Disease	Pneumonitis	CD40LG IKBKB IL6ST	4.15e-04	54	79	3	C3714636
Disease	Experimental Lung Inflammation	CD40LG IKBKB IL6ST	4.15e-04	54	79	3	C0887898
Disease	diabetic angiopathy (is_marker_for)	CD40LG F3	4.59e-04	12	79	2	DOID:11713 (is_marker_for)
Disease	type 2 diabetes mellitus (is_marker_for)	PIK3C2A CD40LG FUCA1 F3	4.96e-04	136	79	4	DOID:9352 (is_marker_for)
Disease	anti-basement membrane glomerulonephritis (implicated_via_orthology)	CD40LG ITGA4	6.31e-04	14	79	2	DOID:4780 (implicated_via_orthology)
Disease	sickle cell anemia (is_marker_for)	CD40LG F3	6.31e-04	14	79	2	DOID:10923 (is_marker_for)
Disease	Alzheimer's disease (is_marker_for)	EPHX1 CD40LG BCL2L1 BACE2 IL6ST	6.43e-04	257	79	5	DOID:10652 (is_marker_for)
Disease	myocardial infarction (biomarker_via_orthology)	CAV3 CACYBP F3 COL1A1	9.12e-04	160	79	4	DOID:5844 (biomarker_via_orthology)
Disease	lupus nephritis (is_marker_for)	CD40LG COL1A1	9.38e-04	17	79	2	DOID:0080162 (is_marker_for)
Disease	Carcinomatosis	EPHX1 BCL2L1 CDH1 IL6ST	9.77e-04	163	79	4	C0205699
Disease	Carcinoma, Spindle-Cell	EPHX1 BCL2L1 CDH1 IL6ST	9.77e-04	163	79	4	C0205697
Disease	Undifferentiated carcinoma	EPHX1 BCL2L1 CDH1 IL6ST	9.77e-04	163	79	4	C0205698
Disease	Anaplastic carcinoma	EPHX1 BCL2L1 CDH1 IL6ST	9.77e-04	163	79	4	C0205696
Disease	Carcinoma	EPHX1 BCL2L1 CDH1 IL6ST	9.99e-04	164	79	4	C0007097
Disease	feeling miserable measurement	PTPRJ CACYBP GABBR1	1.26e-03	79	79	3	EFO_0009598
Disease	disease of metabolism (implicated_via_orthology)	LDHA LDHC	1.44e-03	21	79	2	DOID:0014667 (implicated_via_orthology)
Disease	Nerve Degeneration	TH GRM4 CDH1	1.45e-03	83	79	3	C0027746
Disease	FEV change measurement, response to zileuton	PCNX1 CHRNA2	2.04e-03	25	79	2	EFO_0005921, EFO_0007676
Disease	L lactate dehydrogenase measurement	PTPRJ LDHA	2.21e-03	26	79	2	EFO_0004808
Disease	Nephrotic Syndrome	F3 COL1A1	2.38e-03	27	79	2	C0027726
Disease	Pancreatic Neoplasm	BCL2L1 LDHA CDH1	2.48e-03	100	79	3	C0030297
Disease	Malignant neoplasm of pancreas	BCL2L1 LDHA CDH1	2.62e-03	102	79	3	C0346647
Disease	brain ischemia (biomarker_via_orthology)	TH BCL2L1 IL6ST	2.62e-03	102	79	3	DOID:2316 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
YLGTDQSKWKAYDAT	ESD	191	P10768
KGFDVTVKYTQGSWT	BACE2	141	Q9Y5Z0
SSKTTSVLQWAEKGY	CD40LG	131	P29965
TASKYKGTYKWLLTN	ADGRG4	2391	Q8IZF6
KTKKKYYSTSSHGNW	ADAMTS5	556	Q9UNA0
SGSTIDWTYSQGIKY	CPA1	361	P15085
LKWNYVSTVASEGSY	GRM4	216	Q14833
WAIVNATGTYNSKKY	CHRNA2	231	Q15822
DFLSYKLSQKGYSWS	BCL2L1	11	Q07817
SWSTSYVYKNGTETE	GUCY2C	186	P25092
ESAYEVIKLKGYTSW	LDHA	236	P00338
KSDSKKNSYSYGWSF	CACNG2	166	Q9Y698
AYSSYSLIVSWQKAA	PTPRB	1006	P23467
NVKTVSGDSWKTYSK	PTPRB	1331	P23467
WKVSDNESSSNYTYK	PTPRJ	386	Q12913
YIYWTDGKTKSLSRA	LRP1B	3226	Q9NZR2
VQFSWYGTTIKRDKS	MAN2A1	791	Q16706
QQKYTVTVDYWSFGT	IKBKB	196	O14920
GYYDSTKDDLSWSKT	GABBR1	551	Q9UBS5
ETWKGSKGKQSYTYI	ELAPOR1	526	Q6UXG2
YYVTTSSKLEEWLAN	PCNX1	1706	Q96RV3
GTYVWKIFSQETLTK	PCYOX1	401	Q9UHG3
IKDLKGSDYSWSYQT	MTSS2	246	Q765P7
SKETVKWYQLTAATY	PIK3C2A	1671	O00443
YTVKISNYGWDQSDK	CACYBP	71	Q9HB71
KNTTSVWYTSKGSAV	FUCA1	381	P04066
QSAYEIIKLKGYTSW	LDHC	236	P07864
VVKIGSKYYNWTTAA	LPIN1	506	Q14693
TAEVVYSWTLGKNKS	GABRA3	216	P34903
KYSASKKYNISWELG	HPSE2	246	Q8WWQ2
IKVTEWQQTYTYDSG	JUP	11	P14923
TWGTVFKTLKSLYKT	PAH	186	P00439
TYYYNTETKQSTWEK	PRPF40A	156	O75400
YVYWQTSESKTVVTY	ICOSLG	51	O75144
EVTWYKDGKKLSSSS	OBSCN	1196	Q5VST9
EVTWYKDGKKLSSSS	OBSCN	1656	Q5VST9
ELALSYAKTWSKYTK	ARHGAP29	206	Q52LW3
YWTTGTIISSQRFYK	EPHX1	361	P07099
KYNIQYRTKDASTWS	IL6ST	256	P40189
GAYNIKDSTGKYWTV	FSCN1	421	Q16658
SYYSSHALKLSWNGK	FAM120C	271	Q9NX05
GVWKVSYTTFTVSKY	CAV3	56	P56539
RYGKWTTTQYTEAKA	DMGDH	431	Q9UI17
KRLSSYTECYKWSSS	MAP7D3	486	Q8IWC1
WTGSLFVYNITTNKY	ITGA4	221	P13612
YSKIYSSNISSTVWG	ACOD1	56	A6NK06
SQSVSSSYLTWYQQK	IGKV3-7	46	A0A075B6H7
SFTTVWLIYSKFKAT	KDELR1	71	P24390
YAWDSTYRKFSTKVT	CDH1	101	P12830
WAYLKYSQSKTQSID	LARP1B	816	Q659C4
KYFWTGLSDIQTKGT	MRC1	561	P22897
KKCTFYSSTGGYWTL	FSCN2	301	O14926
AKYSITFTGKWSQTA	SPON2	41	Q9BUD6
YSSVKQQDYSASVWL	PLD5	41	Q8N7P1
KTYWVSKGSAFSTSI	FARSA	171	Q9Y285
YSATGKWTKEYTLQT	LARS2	41	Q15031
TASKVQVSLYGKSWD	PTCH2	141	Q9Y6C5
IYSTQEAEGLYWSKK	MORC4	816	Q8TE76
NIKTVWITSFYKSSL	SLC3A1	156	Q07837
LVKVSKWTYVAYNES	PGAP1	351	Q75T13
YTLASSYASWIQSKV	PRSS8	271	Q16651
TVTWKTYHTYIKASG	ABCC12	776	Q96J65
TYKYDSKTDRWDSSG	OCRL	476	Q01968
AWGKTVIEYKTTKTS	COL1A1	1421	P02452
KAFNWSSTLTYYKSI	ZNF676	176	Q8N7Q3
NYSVYTTKSDVWSFG	TIE1	1026	P35590
QFTYYLWVKSVKTGS	STT3B	231	Q8TCJ2
SWYGKSISYDTNLQT	ZNF75CP	351	Q92670
SPASSEYSWKSVEKY	TTC14	671	Q96N46
QTWSRIATSKATEYY	UBE2U	181	Q5VVX9
TVKAVYGVSKRWSDY	TMEM168	611	Q9H0V1
YTVQISTKSGDWKSK	F3	66	P13726
TLYYWKSSSSGKKTA	F3	186	P13726
TYTKDGFWTYITQIA	ZDHHC17	511	Q8IUH5
KTKEFWSTYTKAQQG	PRRG1	56	O14668
ADKTSELYQKTYWAS	PLBD2	411	Q8NHP8
GWQDVTATSAYKKTS	TPD52	126	P55327
GYKLLNNWLTYSKTT	PPP1R10	71	Q96QC0
SSGKYYWEVDVSGKI	TRIM22	351	Q8IYM9
EKNSYLYSTEITLWT	ZNF783	31	Q6ZMS7
TWNTEYNTYDTISSK	ZNF804A	676	Q7Z570
ATWKEVYTTLKGLYA	TH	261	P07101
QQKGESYWYSVTASV	VPS13D	126	Q5THJ4