Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP17L21 USP17L2 UFSP2 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.42e-201378817GO:0019783
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP17L21 USP17L2 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

4.41e-201148816GO:0004843
GeneOntologyMolecularFunctiondeubiquitinase activity

USP17L21 USP17L2 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

1.79e-191248816GO:0101005
GeneOntologyMolecularFunctioncysteine-type peptidase activity

USP17L21 USP17L2 UFSP2 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

8.46e-181928817GO:0008234
GeneOntologyMolecularFunctionpeptidase activity

USP17L21 USP17L2 UFSP2 USP17L23 USP17L12 PAMR1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 YME1L1 USP17L15 PRSS46P USP17L8 USP17L13 USP17L18

5.79e-126548820GO:0008233
GeneOntologyMolecularFunctionhistone H3K9 acetyltransferase activity

KAT2B KAT2A

5.74e-053882GO:0043992
GeneOntologyMolecularFunctionphosphatidylinositol-3-phosphate binding

PLEKHA5 DENND1A VPS13B

1.24e-0348883GO:0032266
GeneOntologyBiologicalProcessprotein deubiquitination

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

5.04e-181258815GO:0016579
GeneOntologyBiologicalProcessprotein modification by small protein removal

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

4.45e-171448815GO:0070646
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 RNF44 USP17L24 USP17L6P USP17L5 AMBRA1 USP17L19 MED27 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.08e-0710098818GO:0070647
GeneOntologyBiologicalProcesspost-translational protein modification

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 RNF44 USP17L24 USP17L6P USP17L5 AMBRA1 USP17L19 MED27 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

5.20e-0710748818GO:0043687
GeneOntologyBiologicalProcessregulation of tubulin deacetylation

FRY KAT2B KAT2A

1.09e-0422883GO:0090043
GeneOntologyBiologicalProcesstubulin deacetylation

FRY KAT2B KAT2A

1.42e-0424883GO:0090042
GeneOntologyCellularComponentendoplasmic reticulum membrane

USP17L21 PIGT USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

3.91e-0412939015GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

USP17L21 PIGT USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

4.10e-0412999015GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

USP17L21 PIGT USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

5.13e-0413279015GO:0042175
GeneOntologyCellularComponentSAGA-type complex

KAT2B KAT2A TAF4

6.30e-0439903GO:0070461
MousePhenoincreased trophectoderm apoptosis

USP17L2 USP17L15 USP17L13

4.15e-068603MP:0012119
DomainHABP4_PAI-RBP1

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L13 USP17L18

6.30e-26168512PF04774
DomainHABP4_PAIRBP1-bd

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L13 USP17L18

6.30e-26168512IPR006861
DomainUSP_CS

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18

2.32e-18668513IPR018200
DomainUSP_1

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18

5.31e-18708513PS00972
DomainUCH

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18

6.48e-18718513PF00443
DomainUSP_2

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18

6.48e-18718513PS00973
DomainUSP_3

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18

7.88e-18728513PS50235
DomainUSP_dom

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18

7.88e-18728513IPR028889
DomainPeptidase_C19_UCH

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18

7.88e-18728513IPR001394
DomainPCAF_N

KAT2B KAT2A

2.05e-052852IPR009464
DomainHist_acetylase_PCAF

KAT2B KAT2A

2.05e-052852IPR016376
DomainPCAF_N

KAT2B KAT2A

2.05e-052852PF06466
DomainTRPM_tetra

TRPM6 TRPM7

1.22e-044852IPR032415
DomainTRPM_tetra

TRPM6 TRPM7

1.22e-044852PF16519
DomainAlpha_kinase

TRPM6 TRPM7

3.03e-046852PF02816
DomainALPHA_KINASE

TRPM6 TRPM7

3.03e-046852PS51158
DomainAlpha_kinase

TRPM6 TRPM7

3.03e-046852SM00811
DomainMHCK_EF2_kinase

TRPM6 TRPM7

3.03e-046852IPR004166
PathwayREACTOME_RAS_PROCESSING

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

1.32e-22456814MM15671
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 KAT2A USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

1.30e-141916815MM15289
PathwayREACTOME_DEUBIQUITINATION

USP17L21 KAT2B USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 KAT2A USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

7.95e-142626816MM15286
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 KAT2A USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

1.12e-132216815M27578
PathwayREACTOME_DEUBIQUITINATION

USP17L21 KAT2B USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 KAT2A USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

6.12e-132996816M27574
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

USP17L21 USP17L2 USP17L12 RASA2 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.16e-113186815MM15278
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

OTOA USP17L21 KAT2B PIGT USP17L2 USP17L12 USP17L17 RBBP7 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 KAT2A TECTA USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

5.20e-0613896820MM15307
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

OTOA USP17L21 KAT2B PIGT USP17L2 USP17L12 USP17L17 RBBP7 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 KAT2A TECTA USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

1.29e-0514756820M19806
Pubmed

DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.82e-3221911411468161
Pubmed

The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.82e-322191148756639
Pubmed

DUB-1, a deubiquitinating enzyme with growth-suppressing activity.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.82e-322191148622927
Pubmed

DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.82e-3221911414583620
Pubmed

Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.82e-3221911412447969
Pubmed

DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.82e-3221911418980247
Pubmed

JAK2 is required for induction of the murine DUB-1 gene.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

7.75e-322291149154835
Pubmed

DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

4.73e-312491148995226
Pubmed

Cdc25A and Dub3 in a high-stakes balancing act.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

5.46e-3133911520228807
Pubmed

Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

9.74e-3134911520715989
Pubmed

Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

9.74e-313491159806828
Pubmed

The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

9.74e-3134911520368735
Pubmed

The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

9.74e-3134911515780755
Pubmed

The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

9.74e-3134911520403174
Pubmed

USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

9.74e-3134911519188362
Pubmed

Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

9.74e-3134911517109758
Pubmed

Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

9.74e-3134911511941478
Pubmed

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

9.74e-3134911520388806
Pubmed

DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

9.74e-3134911514699124
Pubmed

The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

9.74e-3134911510936051
Pubmed

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

9.74e-3134911521448158
Pubmed

Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

1.07e-3025911421115691
Pubmed

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

1.70e-3035911521239494
Pubmed

Cytokine-regulated protein degradation by the ubiquitination system.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

1.70e-3035911516611142
Pubmed

Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.32e-3026911435816173
Pubmed

The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.91e-3036911520147298
Pubmed

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

4.89e-3037911520228808
Pubmed

Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

1.85e-2929911432527007
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.15e-2550911431806660
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

USP17L21 FAT2 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 KLHL34 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.25e-11674911637196079
Pubmed

High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.

USP17L2 USP17L6P USP17L15 USP17L8

9.10e-091091424207026
Pubmed

Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.

USP17L2 USP17L6P USP17L15 USP17L8

2.14e-081291424695638
Pubmed

A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.

USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L19 USP17L18

2.93e-0811991728625976
Pubmed

ES cell neural differentiation reveals a substantial number of novel ESTs.

USP17L2 USP17L6P USP17L15 USP17L8

4.30e-081491411793228
Pubmed

Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.

USP17L2 USP17L15 USP17L13

6.92e-08491322984479
Pubmed

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.

USP17L2 USP17L6P USP17L15 USP17L8

1.65e-071991428067227
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

LIMK2 HIVEP1 DLC1 FAM171A2 TRPM7 RBBP7 PAK5 MAGI3 PLEKHA5 SIPA1L2 DENND1A DOP1A MAP3K2

3.88e-07861911336931259
Pubmed

Transcriptional coactivator p300/CBP-associated factor and p300/CBP-associated factor type B are required for normal estrogen response of the mouse uterus.

KAT2B KAT2A

6.77e-06291215502373
Pubmed

The channel kinases TRPM6 and TRPM7 are functionally nonredundant.

TRPM6 TRPM7

6.77e-06291216150690
Pubmed

TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP.

TRPM6 TRPM7

6.77e-06291228821869
Pubmed

Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.

TRPM6 TRPM7

6.77e-06291216636202
Pubmed

Recent developments in intestinal magnesium absorption.

TRPM6 TRPM7

6.77e-06291218301276
Pubmed

Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia.

TRPM6 TRPM7

6.77e-06291221602712
Pubmed

The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC.

TRPM6 TRPM7

6.77e-06291218675813
Pubmed

Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin.

TRPM6 TRPM7

6.77e-06291226563869
Pubmed

The Different Roles of The Channel-Kinases TRPM6 and TRPM7.

TRPM6 TRPM7

6.77e-06291226179995
Pubmed

Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis.

TRPM6 TRPM7

6.77e-06291216075242
Pubmed

Evidence for the expression of TRPM6 and TRPM7 in cardiomyocytes from all four chamber walls of the human heart.

TRPM6 TRPM7

6.77e-06291234326388
Pubmed

TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.

TRPM6 TRPM7

6.77e-06291224858416
Pubmed

Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis.

KAT2B KAT2A

6.77e-06291211027331
Pubmed

Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases.

TRPM6 TRPM7

6.77e-06291228220887
Pubmed

Differential mRNA expression and glucocorticoid-mediated regulation of TRPM6 and TRPM7 in the heart and kidney throughout murine pregnancy and development.

TRPM6 TRPM7

6.77e-06291225692682
Pubmed

TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon.

TRPM6 TRPM7

6.77e-06291229912157
Pubmed

Divergent functions of histone acetyltransferases KAT2A and KAT2B in keratinocyte self-renewal and differentiation.

KAT2B KAT2A

6.77e-06291237259855
Pubmed

Magnesium and its transporters in cancer: a novel paradigm in tumour development.

TRPM6 TRPM7

6.77e-06291222671428
Pubmed

Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5.

KAT2B KAT2A

6.77e-06291229555684
Pubmed

The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels.

TRPM6 TRPM7

6.77e-06291224385424
Pubmed

Acetylation of the influenza A virus polymerase subunit PA in the N-terminal domain positively regulates its endonuclease activity.

KAT2B KAT2A

6.77e-06291234270849
Pubmed

Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women.

TRPM6 TRPM7

6.77e-06291219149903
Pubmed

Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7.

TRPM6 TRPM7

6.77e-06291218365021
Pubmed

Gene variation of the transient receptor potential cation channel, subfamily M, members 6 (TRPM6) and 7 (TRPM7), and type 2 diabetes mellitus: a case-control study.

TRPM6 TRPM7

6.77e-06291220875900
Pubmed

Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.

TRPM6 TRPM7

6.77e-06291214976260
Pubmed

Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1.

KAT2B KAT2A

6.77e-06291225269644
Pubmed

Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension.

TRPM6 TRPM7

6.77e-06291218192217
Pubmed

Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells.

KAT2B KAT2A

6.77e-06291228678170
Pubmed

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

DLC1 HELZ2 AMBRA1 PLEKHA5 ZYG11B

7.48e-0610291511214970
Pubmed

Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis.

KAT2B KAT2A TAF4

7.71e-061591312601814
Pubmed

Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.

KAT2B KAT2A TAF4

1.91e-052091310373431
Pubmed

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

KAT2B RBBP7 POGZ KAT2A TAF4

1.93e-0512491520850016
Pubmed

Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22.

OTOA TECTA

2.03e-05391211972037
Pubmed

Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding.

KAT2B KAT2A

2.03e-05391212374802
Pubmed

Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription.

KAT2B KAT2A

2.03e-05391218250157
Pubmed

TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction.

TRPM6 TRPM7

2.03e-05391229515374
Pubmed

Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells.

SPI1 KAT2A

2.03e-05391222904310
Pubmed

GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action.

KAT2B KAT2A

2.03e-05391225426559
Pubmed

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.

KAT2B KAT2A

2.03e-05391227796307
Pubmed

Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.

KAT2B KAT2A

2.03e-05391229174768
Pubmed

In-vitro acetylation of SARS-CoV and SARS-CoV-2 nucleocapsid proteins by human PCAF and GCN5.

KAT2B KAT2A

2.03e-05391233894414
Pubmed

N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation.

TRPM6 TRPM7

2.03e-05391225277194
Pubmed

Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication.

KAT2B KAT2A

2.03e-05391211956210
Pubmed

Interaction network of human early embryonic transcription factors.

KMT2C KAT2B HIVEP1 ATN1 NAB1 POGZ TAF4

3.93e-0535191738297188
Pubmed

Intracellular interleukin-1alpha functionally interacts with histone acetyltransferase complexes.

KAT2B KAT2A

4.05e-05491214612453
Pubmed

The transcriptional co-activator PCAF regulates cdk2 activity.

KAT2B KAT2A

4.05e-05491219773423
Pubmed

Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton.

KAT2B KAT2A

4.05e-05491218430026
Pubmed

The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness.

KAT2B KAT2A

4.05e-05491210022868
Pubmed

P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein.

KAT2B KAT2A

4.05e-05491212878208
Pubmed

Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5.

KAT2B KAT2A

4.05e-05491217301242
Pubmed

The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.

KAT2B KAT2A TAF4

5.41e-052891319114550
Pubmed

Human and mouse proteases: a comparative genomic approach.

USP17L2 USP17L6P USP17L15 USP17L8

6.25e-058191412838346
Pubmed

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.

KAT2B KAT2A TAF4

6.68e-053091318206972
Pubmed

Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5.

KAT2B KAT2A

6.74e-05591210747963
Pubmed

Identification and mapping of human histone acetylation modifier gene homologues.

KAT2B KAT2A

6.74e-0559129722949
Pubmed

Regulation of insulin gene transcription by multiple histone acetyltransferases.

KAT2B KAT2A

6.74e-05591221774670
Pubmed

Gcn5 and PCAF regulate PPARγ and Prdm16 expression to facilitate brown adipogenesis.

KAT2B KAT2A

6.74e-05591225071153
Pubmed

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.

KAT2B KAT2A

6.74e-05591221131905
Pubmed

Acetyltransferases GCN5 and PCAF Are Required for B Lymphocyte Maturation in Mice.

KAT2B KAT2A

6.74e-05591235053209
Pubmed

Ada3 requirement for HAT recruitment to estrogen receptors and estrogen-dependent breast cancer cell proliferation.

KAT2B KAT2A

6.74e-05591218089809
Pubmed

p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation.

KAT2B KAT2A

6.74e-05591218834332
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

KMT2C RBBP7 POGZ TAF4 MED27

8.01e-0516791520362541
Pubmed

Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.

KAT2B KAT2A TAF4

8.93e-053391311564863
Cytoband4p16.1

USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18

5.68e-247991144p16.1
CytobandEnsembl 112 genes in cytogenetic band chr4p16

USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18

1.94e-172229114chr4p16
Cytoband16p12.2

OTOA NPIPB5

2.47e-033791216p12.2
GeneFamilyPHD finger proteins|NuRD complex

RBBP7 CHD5

5.67e-04125421305
GeneFamilyATAC complex

KAT2B KAT2A

6.69e-04135421058
GeneFamilyLysine acetyltransferases|ATAC complex|SAGA complex|GCN5 related N-acetyltransferases

KAT2B KAT2A

1.16e-03175421059
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

KAT2B KAT2A

1.16e-0317542486
GeneFamilyGCN5 related N-acetyltransferases

KAT2B KAT2A

2.32e-03245421134
GeneFamilyTransient receptor potential cation channels

TRPM6 TRPM7

3.15e-0328542249
GeneFamilyActins|Deafness associated genes

OTOA ILDR1 TECTA

4.68e-031135431152
CoexpressionMADAN_DPPA4_TARGETS

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.46e-20868714MM1312
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

1.22e-181128714MM1095
CoexpressionGERY_CEBP_TARGETS

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.06e-161608714MM1155
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP

BRIX1 USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 CPT2 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

3.69e-106478716MM981
CoexpressionBRUINS_UVC_RESPONSE_LATE

USP17L21 USP17L2 UFSP2 USP17L12 RASA2 USP17L17 USP17L20 USP17L11 NAB1 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 EPHA1 USP17L13 USP17L18

6.43e-0811988718MM1062
CoexpressionGRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP

BRIX1 USP17L21 POLR3D USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 HELZ2 USP17L6P USP17L5 USP17L19 CPT2 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

9.09e-0812268718MM979
CoexpressionMARSON_BOUND_BY_FOXP3_STIMULATED

USP17L21 KAT2B USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

2.27e-0610728715MM1031
CoexpressionACEVEDO_METHYLATED_IN_LIVER_CANCER_DN

KMT2C FAT2 PAMR1 HDGFL1 AMBRA1 MAGI3 POGZ LRRC4C OR2V2 SIPA1L2 DENND1A DOP1A

3.09e-058738712M16009
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KMT2C ARHGAP26 AMBRA1 NPIPB5 DENND1A VPS13B

1.54e-06193826779276e775cb2492e8dd36436295a536084a6415
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

KMT2C ARHGAP26 AMBRA1 MAGI3 DENND1A VPS13B

1.84e-0619982694b94b17ca18b8dc27b91da1f2ccf89e03cc7035
Diseaseprimary ovarian insufficiency (implicated_via_orthology)

USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

5.60e-28468215DOID:5426 (implicated_via_orthology)
Diseasecongenital heart disease (implicated_via_orthology)

USP17L21 KMT2C USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18

4.54e-27698216DOID:1682 (implicated_via_orthology)
DiseaseColorectal Neoplasms

DLC1 PTPRD SULT2B1 TRPM7 CHD5 EPHA1

1.25e-04277826C0009404
Diseaseheart disease (implicated_via_orthology)

KAT2B LIPE KAT2A

1.63e-0438823DOID:114 (implicated_via_orthology)
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

OTOA ILDR1 TECTA

3.91e-0451823cv:CN043650
DiseaseNonsyndromic genetic hearing loss

OTOA ILDR1 TECTA

1.26e-0376823cv:C5680182
Diseasethrombin activatable fibrinolysis inhibitor activation peptide measurement

OTOA DENND1A

1.27e-0319822EFO_0008582
Diseaselate-onset Alzheimers disease

DLC1 SPI1 FAM171A2 TECTA EPHA1

1.34e-03292825EFO_1001870
Diseaseserum carcinoembryonic antigen measurement

CA11 SULT2B1

1.40e-0320822EFO_0005760
DiseaseNonsyndromic Deafness

OTOA ILDR1 TECTA

1.51e-0381823C3711374
Diseaseurate measurement, bone density

TRPM6 PTPRD HELZ2 MAGI3 LRRC4C LCP1 DENND1A

1.69e-03619827EFO_0003923, EFO_0004531
Diseasemean reticulocyte volume

LIMK2 KAT2B RASA2 NUP210L HELZ2 KAT2A TAF4 LCP1

1.70e-03799828EFO_0010701
Diseasehearing impairment

OTOA ILDR1 TECTA

2.60e-0398823C1384666
Diseasestimulant use measurement

HIVEP1 DLC1

2.75e-0328822EFO_0600076

Protein segments in the cluster

PeptideGeneStartEntry
NPHSLRTIANFDPRM

EPHA1

886

P21709
QDPNHPAMALNARLA

CHD5

1816

Q8TDI0
MHPAARLSPQQAFPR

BEGAIN

556

Q9BUH8
LSPAISRHSPVQMNR

FCHO2

386

Q0JRZ9
NDPLARLQMLNVTPH

ATN1

1036

P54259
NPHYQSPNMHRRVIR

BRIX1

256

Q8TDN6
QPMTSLQYLHAQPIT

DOP1A

1621

Q5JWR5
MHSLRLLSQNPPSQI

CA11

266

O75493
NVLYPMPADQRRHVS

AMBRA1

996

Q9C0C7
QPPQLGRTNMHYSKL

C5orf64

21

Q2M2E5
TPSLAMMNIRFNHPL

GKN3P

16

P0CG01
QRSIVPTMHYQDSLP

CPT2

36

P23786
RQMATQRFPNDPHVQ

RASA2

486

Q15283
VGLQNVFSHQLPRMP

KAT2A

521

Q92830
SPPLLMHQNRVASLQ

ANKRD34B

251

A5PLL1
SYLNQTSPQPTMRQR

PAK5

271

Q9P286
PNSRQDLHPLLQNMA

OTOA

26

Q7RTW8
DVLQMFLPQRSHPAN

FAM189A1

206

O60320
LNYHTTPSRQPLMQG

KLHL34

256

Q8N239
QLLPIHNQDAFSRMP

KMT2C

1546

Q8NEZ4
RQSPALQHRPMGQSQ

MAGI3

951

Q5TCQ9
PARIEHMTQPNRYQV

HDGFL1

26

Q5TGJ6
VGLQNVFSHQLPRMP

KAT2B

516

Q92831
LRMPNLQNRQPHHFV

NAB1

426

Q13506
NRMHISPNNRNAIHP

LIMK2

186

P53671
RHVIPMNPNTNDLFN

LCP1

141

P13796
PRYSNQNLEDLMPSR

FAT2

4241

Q9NYQ8
AISHPLHYPILMNQR

OR2V2

126

Q96R30
PSLQNRRYPSMARIH

PDE8B

431

O95263
SQVSSYPMHPLLQRD

ILDR1

246

Q86SU0
KSRMPRAQSYPDNHQ

MAP3K2

231

Q9Y2U5
HPQLHPQQMIISRYL

NPIPB5

596

A8MRT5
TLHPQQIMIGPRFNR

LRRC4C

6

Q9HCJ2
LHYQLPQMPDVVVRS

MED27

251

Q6P2C8
QLMHQLPIYDQDPSR

LMCD1

156

Q9NZU5
VNRARYMPQNPHIIA

RBBP7

126

Q16576
NVYRNVMPTLVIPAH

FAM171A2

531

A8MVW0
HPQLHPQQMIISRYL

NPIPB11

611

E5RHQ5
MATLFVRHSPPQQNP

SMPD2

276

O60906
MRNHNSLLSLPQEPY

GAA

671

P10253
HRSQPNLSALSMPNL

DENND1A

881

Q8TEH3
PTTHPNGRQIMLTYL

FRY

1346

Q5TBA9
PISPTNYRQRMHQFL

HELZ2

336

Q9BYK8
NQMLLHPYSRLPTSE

ERVFC1

556

P60507
HQRPENSTQLPLTRM

PRSS46P

101

E5RG02
LNHLLRTNTFRPTMP

ENPP2

531

Q13822
HPRRSSQGATQMPLY

LIPE

946

Q05469
HFMSLQPPLAQSRLQ

NUP210L

1866

Q5VU65
PMQVQSRETPLHQLY

PAMR1

361

Q6UXH9
LRRLNFQTPGMASHP

PTPRD

1321

P23468
ILAIHSDPRLQNPMY

OR1L3

46

Q8NH93
TQTPMVALRQPHNRI

TAF4

761

O00268
NDTRNMPVQLPLAHS

POLR3D

171

P05423
QYSPRLMSSHLPIQI

SULT2B1

116

O00204
PNTNMANVLSSRIYP

SAMD7

56

Q7Z3H4
TMSPLLFQAQPLSHR

SPATA31A6

461

Q5VVP1
YANHMINNHVPRKSP

POGZ

786

Q7Z3K3
VPDMPLTNAQLHLSR

ARHGAP26

571

Q9UNA1
HVSTLLPYMPNNRQQ

SIPA1L2

681

Q9P2F8
VNRQHKYNSVIPMRP

TICAM2

161

Q86XR7
VQPPQLQQLYRHMEL

SPI1

76

P17947
LPQSIQQAMRYLRNH

DLC1

1091

Q96QB1
AVRLNISYPPQNLTM

SIGLEC12

356

Q96PQ1
MAQRQPHSPNQTLIS

BRS3

1

P32247
IRNPHTYLNPPNMET

UFSP2

261

Q9NUQ7
ALVQHQAQPRELMYP

TECTA

16

O75443
RNHPMNLPVQLAASA

ZYG11B

371

Q9C0D3
NNLMRLSQTIPFTPV

TRPM6

1716

Q9BX84
NIIRLYDMQHTPTPI

MIOS

291

Q9NXC5
YQPAQDRLQPHLLEM

PIGT

416

Q969N2
GQFVSLQTQHPRMPL

RNF44

201

Q7L0R7
LQTQHPRMPLQRLDN

RNF44

206

Q7L0R7
TPPLANYMLSREHSQ

USP17L18

101

D6R9N7
ASARHMALNRPQQPP

WASF3

291

Q9UPY6
TPPLANYMLSREHSQ

USP17L5

101

A8MUK1
TPPLANYMLSREHSQ

USP17L21

101

D6R901
TPPLANYMLSREHSQ

USP17L13

101

C9JLJ4
TPPLANYMLSREHSQ

USP17L19

101

D6RCP7
PMHPYSRQTINQLLA

YME1L1

451

Q96TA2
TPPLANYMLSREHSQ

USP17L12

101

C9JPN9
TPPLANYMLSREHSQ

USP17L24

101

Q0WX57
YQPQKRTSRHMQQQP

VPS13B

966

Q7Z7G8
TPPLANYMLSREHSQ

USP17L8

101

P0C7I0
TPPLANYMLSREHSQ

USP17L6P

101

Q6QN14
YQTLPRNMPSHRAQI

PLEKHA5

436

Q9HAU0
TPPLANYMLSREHSQ

USP17L22

101

D6RA61
TPPLANYMLSREHSQ

USP17L15

101

C9J2P7
TPPLANYMLSREHSQ

USP17L17

101

D6RBQ6
LHSQQQSRTPYNMVP

HIVEP1

2386

P15822
NNLMRLSQSIPFTPV

TRPM7

1561

Q96QT4
TPPLANYMLSREHSQ

USP17L23

101

D6RBM5
TPPLANYMLSREHSQ

USP17L2

101

Q6R6M4
TPPLANYMLSREHSQ

USP17L20

101

D6RJB6
TPPLANYMLSREHSQ

USP17L11

101

C9JVI0