| GeneOntologyMolecularFunction | ubiquitin-like protein peptidase activity | USP17L21 USP17L2 UFSP2 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.42e-20 | 137 | 88 | 17 | GO:0019783 |
| GeneOntologyMolecularFunction | cysteine-type deubiquitinase activity | USP17L21 USP17L2 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 4.41e-20 | 114 | 88 | 16 | GO:0004843 |
| GeneOntologyMolecularFunction | deubiquitinase activity | USP17L21 USP17L2 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 1.79e-19 | 124 | 88 | 16 | GO:0101005 |
| GeneOntologyMolecularFunction | cysteine-type peptidase activity | USP17L21 USP17L2 UFSP2 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 8.46e-18 | 192 | 88 | 17 | GO:0008234 |
| GeneOntologyMolecularFunction | peptidase activity | USP17L21 USP17L2 UFSP2 USP17L23 USP17L12 PAMR1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 YME1L1 USP17L15 PRSS46P USP17L8 USP17L13 USP17L18 | 5.79e-12 | 654 | 88 | 20 | GO:0008233 |
| GeneOntologyMolecularFunction | histone H3K9 acetyltransferase activity | KAT2B KAT2A | 5.74e-05 | 3 | 88 | 2 | GO:0043992 |
| GeneOntologyMolecularFunction | phosphatidylinositol-3-phosphate binding | PLEKHA5 DENND1A VPS13B | 1.24e-03 | 48 | 88 | 3 | GO:0032266 |
| GeneOntologyBiologicalProcess | protein deubiquitination | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 5.04e-18 | 125 | 88 | 15 | GO:0016579 |
| GeneOntologyBiologicalProcess | protein modification by small protein removal | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 4.45e-17 | 144 | 88 | 15 | GO:0070646 |
| GeneOntologyBiologicalProcess | protein modification by small protein conjugation or removal | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 RNF44 USP17L24 USP17L6P USP17L5 AMBRA1 USP17L19 MED27 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.08e-07 | 1009 | 88 | 18 | GO:0070647 |
| GeneOntologyBiologicalProcess | post-translational protein modification | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 RNF44 USP17L24 USP17L6P USP17L5 AMBRA1 USP17L19 MED27 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 5.20e-07 | 1074 | 88 | 18 | GO:0043687 |
| GeneOntologyBiologicalProcess | regulation of tubulin deacetylation | FRY KAT2B KAT2A | 1.09e-04 | 22 | 88 | 3 | GO:0090043 |
| GeneOntologyBiologicalProcess | tubulin deacetylation | FRY KAT2B KAT2A | 1.42e-04 | 24 | 88 | 3 | GO:0090042 |
| GeneOntologyCellularComponent | endoplasmic reticulum membrane | USP17L21 PIGT USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 3.91e-04 | 1293 | 90 | 15 | GO:0005789 |
| GeneOntologyCellularComponent | endoplasmic reticulum subcompartment | USP17L21 PIGT USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 4.10e-04 | 1299 | 90 | 15 | GO:0098827 |
| GeneOntologyCellularComponent | nuclear outer membrane-endoplasmic reticulum membrane network | USP17L21 PIGT USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 5.13e-04 | 1327 | 90 | 15 | GO:0042175 |
| GeneOntologyCellularComponent | SAGA-type complex | KAT2B KAT2A TAF4 | 6.30e-04 | 39 | 90 | 3 | GO:0070461 |
| MousePheno | increased trophectoderm apoptosis | USP17L2 USP17L15 USP17L13 | 4.15e-06 | 8 | 60 | 3 | MP:0012119 |
| Domain | HABP4_PAI-RBP1 | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L13 USP17L18 | 6.30e-26 | 16 | 85 | 12 | PF04774 |
| Domain | HABP4_PAIRBP1-bd | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L13 USP17L18 | 6.30e-26 | 16 | 85 | 12 | IPR006861 |
| Domain | USP_CS | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18 | 2.32e-18 | 66 | 85 | 13 | IPR018200 |
| Domain | USP_1 | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18 | 5.31e-18 | 70 | 85 | 13 | PS00972 |
| Domain | UCH | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18 | 6.48e-18 | 71 | 85 | 13 | PF00443 |
| Domain | USP_2 | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18 | 6.48e-18 | 71 | 85 | 13 | PS00973 |
| Domain | USP_3 | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18 | 7.88e-18 | 72 | 85 | 13 | PS50235 |
| Domain | USP_dom | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18 | 7.88e-18 | 72 | 85 | 13 | IPR028889 |
| Domain | Peptidase_C19_UCH | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18 | 7.88e-18 | 72 | 85 | 13 | IPR001394 |
| Domain | PCAF_N | KAT2B KAT2A | 2.05e-05 | 2 | 85 | 2 | IPR009464 |
| Domain | Hist_acetylase_PCAF | KAT2B KAT2A | 2.05e-05 | 2 | 85 | 2 | IPR016376 |
| Domain | PCAF_N | KAT2B KAT2A | 2.05e-05 | 2 | 85 | 2 | PF06466 |
| Domain | TRPM_tetra | TRPM6 TRPM7 | 1.22e-04 | 4 | 85 | 2 | IPR032415 |
| Domain | TRPM_tetra | TRPM6 TRPM7 | 1.22e-04 | 4 | 85 | 2 | PF16519 |
| Domain | Alpha_kinase | TRPM6 TRPM7 | 3.03e-04 | 6 | 85 | 2 | PF02816 |
| Domain | ALPHA_KINASE | TRPM6 TRPM7 | 3.03e-04 | 6 | 85 | 2 | PS51158 |
| Domain | Alpha_kinase | TRPM6 TRPM7 | 3.03e-04 | 6 | 85 | 2 | SM00811 |
| Domain | MHCK_EF2_kinase | TRPM6 TRPM7 | 3.03e-04 | 6 | 85 | 2 | IPR004166 |
| Pathway | REACTOME_RAS_PROCESSING | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 1.32e-22 | 45 | 68 | 14 | MM15671 |
| Pathway | REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 KAT2A USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 1.30e-14 | 191 | 68 | 15 | MM15289 |
| Pathway | REACTOME_DEUBIQUITINATION | USP17L21 KAT2B USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 KAT2A USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 7.95e-14 | 262 | 68 | 16 | MM15286 |
| Pathway | REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 KAT2A USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 1.12e-13 | 221 | 68 | 15 | M27578 |
| Pathway | REACTOME_DEUBIQUITINATION | USP17L21 KAT2B USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 KAT2A USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 6.12e-13 | 299 | 68 | 16 | M27574 |
| Pathway | REACTOME_MAPK_FAMILY_SIGNALING_CASCADES | USP17L21 USP17L2 USP17L12 RASA2 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.16e-11 | 318 | 68 | 15 | MM15278 |
| Pathway | REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION | OTOA USP17L21 KAT2B PIGT USP17L2 USP17L12 USP17L17 RBBP7 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 KAT2A TECTA USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 5.20e-06 | 1389 | 68 | 20 | MM15307 |
| Pathway | REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION | OTOA USP17L21 KAT2B PIGT USP17L2 USP17L12 USP17L17 RBBP7 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 KAT2A TECTA USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 1.29e-05 | 1475 | 68 | 20 | M19806 |
| Pubmed | DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.82e-32 | 21 | 91 | 14 | 11468161 |
| Pubmed | The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.82e-32 | 21 | 91 | 14 | 8756639 |
| Pubmed | DUB-1, a deubiquitinating enzyme with growth-suppressing activity. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.82e-32 | 21 | 91 | 14 | 8622927 |
| Pubmed | DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.82e-32 | 21 | 91 | 14 | 14583620 |
| Pubmed | Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.82e-32 | 21 | 91 | 14 | 12447969 |
| Pubmed | DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.82e-32 | 21 | 91 | 14 | 18980247 |
| Pubmed | JAK2 is required for induction of the murine DUB-1 gene. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 7.75e-32 | 22 | 91 | 14 | 9154835 |
| Pubmed | DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 4.73e-31 | 24 | 91 | 14 | 8995226 |
| Pubmed | Cdc25A and Dub3 in a high-stakes balancing act. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 5.46e-31 | 33 | 91 | 15 | 20228807 |
| Pubmed | Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 9.74e-31 | 34 | 91 | 15 | 20715989 |
| Pubmed | Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 9.74e-31 | 34 | 91 | 15 | 9806828 |
| Pubmed | The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 9.74e-31 | 34 | 91 | 15 | 20368735 |
| Pubmed | The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 9.74e-31 | 34 | 91 | 15 | 15780755 |
| Pubmed | The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 9.74e-31 | 34 | 91 | 15 | 20403174 |
| Pubmed | USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 9.74e-31 | 34 | 91 | 15 | 19188362 |
| Pubmed | Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 9.74e-31 | 34 | 91 | 15 | 17109758 |
| Pubmed | Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 9.74e-31 | 34 | 91 | 15 | 11941478 |
| Pubmed | The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 9.74e-31 | 34 | 91 | 15 | 20388806 |
| Pubmed | DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 9.74e-31 | 34 | 91 | 15 | 14699124 |
| Pubmed | The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 9.74e-31 | 34 | 91 | 15 | 10936051 |
| Pubmed | The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 9.74e-31 | 34 | 91 | 15 | 21448158 |
| Pubmed | Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 1.07e-30 | 25 | 91 | 14 | 21115691 |
| Pubmed | Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 1.70e-30 | 35 | 91 | 15 | 21239494 |
| Pubmed | Cytokine-regulated protein degradation by the ubiquitination system. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 1.70e-30 | 35 | 91 | 15 | 16611142 |
| Pubmed | Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.32e-30 | 26 | 91 | 14 | 35816173 |
| Pubmed | The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.91e-30 | 36 | 91 | 15 | 20147298 |
| Pubmed | Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 4.89e-30 | 37 | 91 | 15 | 20228808 |
| Pubmed | Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 1.85e-29 | 29 | 91 | 14 | 32527007 |
| Pubmed | DUX is a non-essential synchronizer of zygotic genome activation. | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.15e-25 | 50 | 91 | 14 | 31806660 |
| Pubmed | USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. | USP17L21 FAT2 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 KLHL34 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.25e-11 | 674 | 91 | 16 | 37196079 |
| Pubmed | High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency. | USP17L2 USP17L6P USP17L15 USP17L8 | 9.10e-09 | 10 | 91 | 4 | 24207026 |
| Pubmed | Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells. | USP17L2 USP17L6P USP17L15 USP17L8 | 2.14e-08 | 12 | 91 | 4 | 24695638 |
| Pubmed | A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. | USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L19 USP17L18 | 2.93e-08 | 119 | 91 | 7 | 28625976 |
| Pubmed | ES cell neural differentiation reveals a substantial number of novel ESTs. | USP17L2 USP17L6P USP17L15 USP17L8 | 4.30e-08 | 14 | 91 | 4 | 11793228 |
| Pubmed | Embryonic demise caused by targeted disruption of a cysteine protease Dub-2. | USP17L2 USP17L15 USP17L13 | 6.92e-08 | 4 | 91 | 3 | 22984479 |
| Pubmed | CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1. | USP17L2 USP17L6P USP17L15 USP17L8 | 1.65e-07 | 19 | 91 | 4 | 28067227 |
| Pubmed | A central chaperone-like role for 14-3-3 proteins in human cells. | LIMK2 HIVEP1 DLC1 FAM171A2 TRPM7 RBBP7 PAK5 MAGI3 PLEKHA5 SIPA1L2 DENND1A DOP1A MAP3K2 | 3.88e-07 | 861 | 91 | 13 | 36931259 |
| Pubmed | Transcriptional coactivator p300/CBP-associated factor and p300/CBP-associated factor type B are required for normal estrogen response of the mouse uterus. | KAT2B KAT2A | 6.77e-06 | 2 | 91 | 2 | 15502373 |
| Pubmed | The channel kinases TRPM6 and TRPM7 are functionally nonredundant. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 16150690 |
| Pubmed | TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 28821869 |
| Pubmed | Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 16636202 |
| Pubmed | Recent developments in intestinal magnesium absorption. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 18301276 |
| Pubmed | Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 21602712 |
| Pubmed | The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 18675813 |
| Pubmed | Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 26563869 |
| Pubmed | The Different Roles of The Channel-Kinases TRPM6 and TRPM7. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 26179995 |
| Pubmed | Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 16075242 |
| Pubmed | Evidence for the expression of TRPM6 and TRPM7 in cardiomyocytes from all four chamber walls of the human heart. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 34326388 |
| Pubmed | TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 24858416 |
| Pubmed | Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis. | KAT2B KAT2A | 6.77e-06 | 2 | 91 | 2 | 11027331 |
| Pubmed | Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 28220887 |
| Pubmed | Differential mRNA expression and glucocorticoid-mediated regulation of TRPM6 and TRPM7 in the heart and kidney throughout murine pregnancy and development. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 25692682 |
| Pubmed | TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 29912157 |
| Pubmed | Divergent functions of histone acetyltransferases KAT2A and KAT2B in keratinocyte self-renewal and differentiation. | KAT2B KAT2A | 6.77e-06 | 2 | 91 | 2 | 37259855 |
| Pubmed | Magnesium and its transporters in cancer: a novel paradigm in tumour development. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 22671428 |
| Pubmed | Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5. | KAT2B KAT2A | 6.77e-06 | 2 | 91 | 2 | 29555684 |
| Pubmed | The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 24385424 |
| Pubmed | Acetylation of the influenza A virus polymerase subunit PA in the N-terminal domain positively regulates its endonuclease activity. | KAT2B KAT2A | 6.77e-06 | 2 | 91 | 2 | 34270849 |
| Pubmed | Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 19149903 |
| Pubmed | Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 18365021 |
| Pubmed | Gene variation of the transient receptor potential cation channel, subfamily M, members 6 (TRPM6) and 7 (TRPM7), and type 2 diabetes mellitus: a case-control study. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 20875900 |
| Pubmed | Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 14976260 |
| Pubmed | Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1. | KAT2B KAT2A | 6.77e-06 | 2 | 91 | 2 | 25269644 |
| Pubmed | Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension. | TRPM6 TRPM7 | 6.77e-06 | 2 | 91 | 2 | 18192217 |
| Pubmed | Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells. | KAT2B KAT2A | 6.77e-06 | 2 | 91 | 2 | 28678170 |
| Pubmed | Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. | DLC1 HELZ2 AMBRA1 PLEKHA5 ZYG11B | 7.48e-06 | 102 | 91 | 5 | 11214970 |
| Pubmed | Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis. | KAT2B KAT2A TAF4 | 7.71e-06 | 15 | 91 | 3 | 12601814 |
| Pubmed | Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. | KAT2B KAT2A TAF4 | 1.91e-05 | 20 | 91 | 3 | 10373431 |
| Pubmed | Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. | KAT2B RBBP7 POGZ KAT2A TAF4 | 1.93e-05 | 124 | 91 | 5 | 20850016 |
| Pubmed | Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22. | OTOA TECTA | 2.03e-05 | 3 | 91 | 2 | 11972037 |
| Pubmed | Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. | KAT2B KAT2A | 2.03e-05 | 3 | 91 | 2 | 12374802 |
| Pubmed | Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription. | KAT2B KAT2A | 2.03e-05 | 3 | 91 | 2 | 18250157 |
| Pubmed | TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction. | TRPM6 TRPM7 | 2.03e-05 | 3 | 91 | 2 | 29515374 |
| Pubmed | Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells. | SPI1 KAT2A | 2.03e-05 | 3 | 91 | 2 | 22904310 |
| Pubmed | GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action. | KAT2B KAT2A | 2.03e-05 | 3 | 91 | 2 | 25426559 |
| Pubmed | KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification. | KAT2B KAT2A | 2.03e-05 | 3 | 91 | 2 | 27796307 |
| Pubmed | Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development. | KAT2B KAT2A | 2.03e-05 | 3 | 91 | 2 | 29174768 |
| Pubmed | In-vitro acetylation of SARS-CoV and SARS-CoV-2 nucleocapsid proteins by human PCAF and GCN5. | KAT2B KAT2A | 2.03e-05 | 3 | 91 | 2 | 33894414 |
| Pubmed | N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation. | TRPM6 TRPM7 | 2.03e-05 | 3 | 91 | 2 | 25277194 |
| Pubmed | Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication. | KAT2B KAT2A | 2.03e-05 | 3 | 91 | 2 | 11956210 |
| Pubmed | Interaction network of human early embryonic transcription factors. | KMT2C KAT2B HIVEP1 ATN1 NAB1 POGZ TAF4 | 3.93e-05 | 351 | 91 | 7 | 38297188 |
| Pubmed | Intracellular interleukin-1alpha functionally interacts with histone acetyltransferase complexes. | KAT2B KAT2A | 4.05e-05 | 4 | 91 | 2 | 14612453 |
| Pubmed | The transcriptional co-activator PCAF regulates cdk2 activity. | KAT2B KAT2A | 4.05e-05 | 4 | 91 | 2 | 19773423 |
| Pubmed | Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton. | KAT2B KAT2A | 4.05e-05 | 4 | 91 | 2 | 18430026 |
| Pubmed | The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness. | KAT2B KAT2A | 4.05e-05 | 4 | 91 | 2 | 10022868 |
| Pubmed | P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein. | KAT2B KAT2A | 4.05e-05 | 4 | 91 | 2 | 12878208 |
| Pubmed | Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5. | KAT2B KAT2A | 4.05e-05 | 4 | 91 | 2 | 17301242 |
| Pubmed | The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. | KAT2B KAT2A TAF4 | 5.41e-05 | 28 | 91 | 3 | 19114550 |
| Pubmed | Human and mouse proteases: a comparative genomic approach. | USP17L2 USP17L6P USP17L15 USP17L8 | 6.25e-05 | 81 | 91 | 4 | 12838346 |
| Pubmed | A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. | KAT2B KAT2A TAF4 | 6.68e-05 | 30 | 91 | 3 | 18206972 |
| Pubmed | Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. | KAT2B KAT2A | 6.74e-05 | 5 | 91 | 2 | 10747963 |
| Pubmed | Identification and mapping of human histone acetylation modifier gene homologues. | KAT2B KAT2A | 6.74e-05 | 5 | 91 | 2 | 9722949 |
| Pubmed | Regulation of insulin gene transcription by multiple histone acetyltransferases. | KAT2B KAT2A | 6.74e-05 | 5 | 91 | 2 | 21774670 |
| Pubmed | Gcn5 and PCAF regulate PPARγ and Prdm16 expression to facilitate brown adipogenesis. | KAT2B KAT2A | 6.74e-05 | 5 | 91 | 2 | 25071153 |
| Pubmed | Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. | KAT2B KAT2A | 6.74e-05 | 5 | 91 | 2 | 21131905 |
| Pubmed | Acetyltransferases GCN5 and PCAF Are Required for B Lymphocyte Maturation in Mice. | KAT2B KAT2A | 6.74e-05 | 5 | 91 | 2 | 35053209 |
| Pubmed | Ada3 requirement for HAT recruitment to estrogen receptors and estrogen-dependent breast cancer cell proliferation. | KAT2B KAT2A | 6.74e-05 | 5 | 91 | 2 | 18089809 |
| Pubmed | p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation. | KAT2B KAT2A | 6.74e-05 | 5 | 91 | 2 | 18834332 |
| Pubmed | An Oct4-centered protein interaction network in embryonic stem cells. | KMT2C RBBP7 POGZ TAF4 MED27 | 8.01e-05 | 167 | 91 | 5 | 20362541 |
| Pubmed | Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. | KAT2B KAT2A TAF4 | 8.93e-05 | 33 | 91 | 3 | 11564863 |
| Cytoband | 4p16.1 | USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18 | 5.68e-24 | 79 | 91 | 14 | 4p16.1 |
| Cytoband | Ensembl 112 genes in cytogenetic band chr4p16 | USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18 | 1.94e-17 | 222 | 91 | 14 | chr4p16 |
| Cytoband | 16p12.2 | OTOA NPIPB5 | 2.47e-03 | 37 | 91 | 2 | 16p12.2 |
| GeneFamily | PHD finger proteins|NuRD complex | RBBP7 CHD5 | 5.67e-04 | 12 | 54 | 2 | 1305 |
| GeneFamily | ATAC complex | KAT2B KAT2A | 6.69e-04 | 13 | 54 | 2 | 1058 |
| GeneFamily | Lysine acetyltransferases|ATAC complex|SAGA complex|GCN5 related N-acetyltransferases | KAT2B KAT2A | 1.16e-03 | 17 | 54 | 2 | 1059 |
| GeneFamily | Zinc fingers ZZ-type|Lysine acetyltransferases | KAT2B KAT2A | 1.16e-03 | 17 | 54 | 2 | 486 |
| GeneFamily | GCN5 related N-acetyltransferases | KAT2B KAT2A | 2.32e-03 | 24 | 54 | 2 | 1134 |
| GeneFamily | Transient receptor potential cation channels | TRPM6 TRPM7 | 3.15e-03 | 28 | 54 | 2 | 249 |
| GeneFamily | Actins|Deafness associated genes | OTOA ILDR1 TECTA | 4.68e-03 | 113 | 54 | 3 | 1152 |
| Coexpression | MADAN_DPPA4_TARGETS | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.46e-20 | 86 | 87 | 14 | MM1312 |
| Coexpression | GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 1.22e-18 | 112 | 87 | 14 | MM1095 |
| Coexpression | GERY_CEBP_TARGETS | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.06e-16 | 160 | 87 | 14 | MM1155 |
| Coexpression | GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP | BRIX1 USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 CPT2 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 3.69e-10 | 647 | 87 | 16 | MM981 |
| Coexpression | BRUINS_UVC_RESPONSE_LATE | USP17L21 USP17L2 UFSP2 USP17L12 RASA2 USP17L17 USP17L20 USP17L11 NAB1 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 EPHA1 USP17L13 USP17L18 | 6.43e-08 | 1198 | 87 | 18 | MM1062 |
| Coexpression | GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP | BRIX1 USP17L21 POLR3D USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 HELZ2 USP17L6P USP17L5 USP17L19 CPT2 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 9.09e-08 | 1226 | 87 | 18 | MM979 |
| Coexpression | MARSON_BOUND_BY_FOXP3_STIMULATED | USP17L21 KAT2B USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 2.27e-06 | 1072 | 87 | 15 | MM1031 |
| Coexpression | ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN | KMT2C FAT2 PAMR1 HDGFL1 AMBRA1 MAGI3 POGZ LRRC4C OR2V2 SIPA1L2 DENND1A DOP1A | 3.09e-05 | 873 | 87 | 12 | M16009 |
| ToppCell | nucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2 | KMT2C ARHGAP26 AMBRA1 NPIPB5 DENND1A VPS13B | 1.54e-06 | 193 | 82 | 6 | 779276e775cb2492e8dd36436295a536084a6415 |
| ToppCell | Tracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations | KMT2C ARHGAP26 AMBRA1 MAGI3 DENND1A VPS13B | 1.84e-06 | 199 | 82 | 6 | 94b94b17ca18b8dc27b91da1f2ccf89e03cc7035 |
| Disease | primary ovarian insufficiency (implicated_via_orthology) | USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 5.60e-28 | 46 | 82 | 15 | DOID:5426 (implicated_via_orthology) |
| Disease | congenital heart disease (implicated_via_orthology) | USP17L21 KMT2C USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18 | 4.54e-27 | 69 | 82 | 16 | DOID:1682 (implicated_via_orthology) |
| Disease | Colorectal Neoplasms | DLC1 PTPRD SULT2B1 TRPM7 CHD5 EPHA1 | 1.25e-04 | 277 | 82 | 6 | C0009404 |
| Disease | heart disease (implicated_via_orthology) | KAT2B LIPE KAT2A | 1.63e-04 | 38 | 82 | 3 | DOID:114 (implicated_via_orthology) |
| Disease | Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive | OTOA ILDR1 TECTA | 3.91e-04 | 51 | 82 | 3 | cv:CN043650 |
| Disease | Nonsyndromic genetic hearing loss | OTOA ILDR1 TECTA | 1.26e-03 | 76 | 82 | 3 | cv:C5680182 |
| Disease | thrombin activatable fibrinolysis inhibitor activation peptide measurement | OTOA DENND1A | 1.27e-03 | 19 | 82 | 2 | EFO_0008582 |
| Disease | late-onset Alzheimers disease | DLC1 SPI1 FAM171A2 TECTA EPHA1 | 1.34e-03 | 292 | 82 | 5 | EFO_1001870 |
| Disease | serum carcinoembryonic antigen measurement | CA11 SULT2B1 | 1.40e-03 | 20 | 82 | 2 | EFO_0005760 |
| Disease | Nonsyndromic Deafness | OTOA ILDR1 TECTA | 1.51e-03 | 81 | 82 | 3 | C3711374 |
| Disease | urate measurement, bone density | TRPM6 PTPRD HELZ2 MAGI3 LRRC4C LCP1 DENND1A | 1.69e-03 | 619 | 82 | 7 | EFO_0003923, EFO_0004531 |
| Disease | mean reticulocyte volume | LIMK2 KAT2B RASA2 NUP210L HELZ2 KAT2A TAF4 LCP1 | 1.70e-03 | 799 | 82 | 8 | EFO_0010701 |
| Disease | hearing impairment | OTOA ILDR1 TECTA | 2.60e-03 | 98 | 82 | 3 | C1384666 |
| Disease | stimulant use measurement | HIVEP1 DLC1 | 2.75e-03 | 28 | 82 | 2 | EFO_0600076 |