Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ARM-type_fold	RALGAPA1 MROH5 ECPAS PUM1 CLHC1	4.30e-03	339	59	5	IPR016024
Domain	SNF2_N	CHD3 SRCAP	4.58e-03	32	59	2	IPR000330
Domain	SNF2_N	CHD3 SRCAP	4.58e-03	32	59	2	PF00176
Domain	Ank_2	ANKRD31 ANKFY1 ANK3 ASB7	4.74e-03	215	59	4	PF12796
Domain	P-loop_NTPase	NPHP3 MYO1D MCM3 CHD3 RAB20 SRCAP DNA2 DNAH8	4.98e-03	848	59	8	IPR027417
Domain	Ank	ANKRD31 ANKFY1 ANK3 ASB7	5.83e-03	228	59	4	PF00023
Domain	-	ANKRD31 ANKFY1 ANK3 ASB7	7.80e-03	248	59	4	1.25.40.20
Domain	ANK	ANKRD31 ANKFY1 ANK3 ASB7	8.13e-03	251	59	4	SM00248
Domain	ANK_REPEAT	ANKRD31 ANKFY1 ANK3 ASB7	8.36e-03	253	59	4	PS50088
Domain	Ankyrin_rpt-contain_dom	ANKRD31 ANKFY1 ANK3 ASB7	8.47e-03	254	59	4	IPR020683
Domain	ANK_REP_REGION	ANKRD31 ANKFY1 ANK3 ASB7	8.47e-03	254	59	4	PS50297
Domain	-	NPHP3 MCM3 CHD3 RAB20 SRCAP DNA2 DNAH8	8.86e-03	746	59	7	3.40.50.300
Domain	Cyt_P450_E_grp-I	CYP4Z1 CYP24A1	8.90e-03	45	59	2	IPR002401
Domain	Ankyrin_rpt	ANKRD31 ANKFY1 ANK3 ASB7	9.42e-03	262	59	4	IPR002110
Pubmed	Genome-wide association study identifies five new schizophrenia loci.	CNNM2 ANK3 PLCB2 ITIH3	7.39e-08	23	61	4	21926974
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RALGAPA1 LRIG3 TTLL4 KDM2B SPG11 SMG5 ECPAS DNA2	3.94e-06	529	61	8	14621295
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	MYO1D HSPA4L CIAO3 SUPT16H BEND3 SPG11 CHD3 STOX1 SRCAP SCIMP IL1R1 DNAH8	6.53e-06	1442	61	12	35575683
Pubmed	The Expression of HSPD1, SCUBE3, CXCL14 and Its Relations with the Prognosis in Osteosarcoma.	SCUBE3 CXCL14	9.07e-06	3	61	2	27259322
Pubmed	Role of Polymorphisms of FAM13A, PHLDB1, and CYP24A1 in Breast Cancer Risk.	FAM13A CYP24A1	9.07e-06	3	61	2	31215377
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LRIG3 ANKFY1 CDK19 BEND3 MED13L PUM1	7.98e-05	407	61	6	12693553
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ANKFY1 KDM2B BEND3 CHD3 RABGAP1 ECPAS	9.24e-05	418	61	6	34709266
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	ANKFY1 HSPA4L SUPT16H MCM3 DNAJB5 ECPAS PUM1	1.25e-04	638	61	7	33239621
Pubmed	A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.	SUPT16H MCM3	1.35e-04	10	61	2	21055985
Pubmed	Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication.	SUPT16H MCM3	1.35e-04	10	61	2	16902406
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	BRD7 KDM2B CHD3 SRCAP	1.71e-04	157	61	4	30186101
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	MAGED1 BRD7 SUPT16H BEND3 CHD3 DNA2	1.73e-04	469	61	6	27634302
Pubmed	Human transcription factor protein interaction networks.	MAGED1 MYO1D HSPA4L BRD7 KDM2B BEND3 CHD3 SMG5 SRCAP PUM1	1.77e-04	1429	61	10	35140242
Pubmed	Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation.	PLCB2 IL1R1	1.97e-04	12	61	2	25959047
Pubmed	Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.	CNNM2 ANK3 ITIH3	2.08e-04	65	61	3	23453885
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	RALGAPA1 ARHGAP1 ANK3 HSPA4L MCM3 MPHOSPH9 ECPAS	2.36e-04	708	61	7	39231216
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	RALGAPA1 ARHGAP1 OXA1L MAGED1 ANK3 HSPA4L SUPT16H SPG11 DNAJB5 DNA2	2.44e-04	1487	61	10	33957083
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	OXA1L MAGED1 ANK3 BEND3 MCM3 RABGAP1	2.85e-04	515	61	6	31617661
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	RALGAPA1 POLR3B MAGED1 TTLL4 SPG11 MPHOSPH9 PUM1	2.92e-04	733	61	7	34672954
Pubmed	Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization.	MAGED1 CDK19 MALSU1	3.05e-04	74	61	3	15031102
Pubmed	MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.	CIAO3 DNA2	3.13e-04	15	61	2	22678361
Pubmed	Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.	ANK3 ECPAS	4.55e-04	18	61	2	31910261
Pubmed	Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.	HSPA4L MCM3 ECPAS	5.24e-04	89	61	3	27034005
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	MAGED1 MYO1D KDM2B MCM3 RABGAP1 SRCAP	5.75e-04	588	61	6	38580884
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	NPHP3 ANK3 TTLL4 CHD3 SRCAP CPLANE1 PUM1 DNA2	5.91e-04	1084	61	8	11544199
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	HSPA4L BRD7 SUPT16H CHD3 SRCAP	6.43e-04	394	61	5	27248496
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ANKFY1 CDK19 SMG5 MED13L	6.67e-04	225	61	4	12168954
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	POLR3B MSMO1 HSPA4L MCM3 CHD3 RABGAP1 SRCAP	6.90e-04	847	61	7	35235311
Pubmed	The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.	HSPA4L DNAJB5	7.48e-04	23	61	2	21231916
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	MAGED1 MPHOSPH9 PUM1	7.57e-04	101	61	3	24613305
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	CDK19 SMG5 MED13L	8.24e-04	104	61	3	10470851
Pubmed	A protein interaction landscape of breast cancer.	ANK3 HSPA4L BRD7 SUPT16H SMG5 ECPAS	8.50e-04	634	61	6	34591612
Pubmed	Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.	SUPT16H MCM3	8.84e-04	25	61	2	15385968
Pubmed	RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.	POLR3B SUPT16H MCM3 CHD3 PUM1	9.03e-04	425	61	5	21081503
Pubmed	Genome-wide association analysis identifies 13 new risk loci for schizophrenia.	CNNM2 MPHOSPH9 ITIH3	9.44e-04	109	61	3	23974872
Pubmed	ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.	SUPT16H MCM3	9.57e-04	26	61	2	34162889
Pubmed	MxA interacts with and is modified by the SUMOylation machinery.	BRD7 CHD3	1.03e-03	27	61	2	25447205
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	HSPA4L BRD7 SUPT16H MCM3 SRCAP	1.05e-03	440	61	5	34244565
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	ARHGAP1 ANKFY1 MAGED1 FAM13A HSPA4L MCM3 ECPAS	1.09e-03	916	61	7	32203420
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	RALGAPA1 MAGED1 MPHOSPH9 ECPAS PUM1	1.12e-03	446	61	5	24255178
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	ARHGAP1 OXA1L MYO1D HSPA4L BRD7 SUPT16H BEND3 RABGAP1 MALSU1	1.13e-03	1496	61	9	32877691
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	BRD7 KDM2B CHD3 MED13L	1.27e-03	268	61	4	33640491
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	TTLL4 BRD7 SUPT16H MCM3 DNA2	1.63e-03	486	61	5	30940648
Pubmed	Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex.	LRIG3 STOX1	1.64e-03	34	61	2	25391964
Pubmed	Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.	CNNM2 ANK3	1.73e-03	35	61	2	22688191
GeneFamily	Ankyrin repeat domain containing	ANKRD31 ANKFY1 ANK3 ASB7	1.62e-03	242	38	4	403
GeneFamily	Cyclins\|Mediator complex	CDK19 MED13L	2.18e-03	33	38	2	1061
Disease	attention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia	CNNM2 ANK3 IL1R1 ITIH3	4.76e-05	101	58	4	EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
Disease	JT interval	LRIG3 FADS1 BEND3 CFAP70 DNAJB5	1.28e-04	248	58	5	EFO_0007885
Disease	Intellectual Disability	RALGAPA1 POLR3B SUPT16H CHD3 MED13L PUM1	2.43e-04	447	58	6	C3714756
Disease	unipolar depression, bipolar disorder	CNNM2 ANK3 KDM2B ITIH3	2.55e-04	156	58	4	EFO_0003761, MONDO_0004985
Disease	free cholesterol in large VLDL measurement	ANKRD31 FADS1 ITIH3	3.30e-04	68	58	3	EFO_0022265
Disease	albumin:globulin ratio measurement	FADS1 MPHOSPH9 IL1R1	4.07e-04	73	58	3	EFO_0005128
Disease	alkaline phosphatase measurement	RALGAPA1 CNNM2 NPHP3 FADS1 CYP24A1 SCUBE3 CHD3 ITIH3	7.96e-04	1015	58	8	EFO_0004533
Disease	Bell's palsy	MAGED1 DNAH8 SLC38A3	1.08e-03	102	58	3	EFO_0007167
Disease	Ciliopathies	NPHP3 CPLANE1 DNAH8	1.34e-03	110	58	3	C4277690
Disease	granulocyte percentage of myeloid white cells	FADS1 SCUBE3 BEND3 MED13L	1.92e-03	268	58	4	EFO_0007997

Protein segments in the cluster

Peptide	Gene	Start	Entry
YGEFLKKYHKKKKIM	FAM227B	121	Q96M60
KKAYRKMALKYHPDK	DNAJB5	21	O75953
LPIAKVMKDYLKHKF	ASB7	301	Q9H672
YMEKHKVKPDSKVFL	CDK19	296	Q9BWU1
IYYKAAKKLLHSGMK	BRD7	216	Q9NPI1
KKISHYYEHLKKKFM	C5orf52	116	A6NGY3
ALYKKILKYKMLDEQ	RAB20	156	Q9NX57
SYKKPLYGISHKIME	BEND3	126	Q5T5X7
YSDHMYKMPEKILPK	ANKRD31	401	Q8N7Z5
YKMIKSKTEYPLHKA	ANKFY1	211	Q9P2R3
PYMKKYKIQKDKPET	MSMO1	76	Q15800
QKKLKKYEKEYHTMR	RABGAP1	811	Q9Y3P9
YFYPMVLKKKEESKE	MED13L	241	Q71F56
NKLVKYLMLKDYTKV	MAGED1	476	Q9Y5V3
LMDHYEPSYIKKKEC	LRIG3	956	Q6UXM1
KMYKVYLGDIPLKTK	ECPAS	301	Q5VYK3
YHKELPENYKTMKGI	NUDT6	301	P53370
AKTVMVKAYLKKYDP	DNAH8	2461	Q96JB1
NEMKLPSLKDIYYKK	MPHOSPH9	251	Q99550
EMALYQKKHGIKLYK	OXA1L	201	Q15070
PMAEEYSEYKHIKAK	FAM13A	991	O94988
IRYSDVKKLEMKPKY	CXCL14	46	O95715
YGKHILAKLEKYYMK	PUM1	1156	Q14671
AFMKKYIHVAKIIKP	MCM3	566	P25205
PKKLYPEYHKVYHMM	OSGIN2	346	Q9Y236
NAIAEMKYPKVKKYC	KDM2B	216	Q8NHM5
LVEYHKKYGKIFRMK	CYP24A1	86	Q07973
PGKVKYMSKPSYIHK	CPLANE1	3021	Q9H799
KRKVKDPHYAEMEEK	CHD3	606	Q12873
AEQAYKYMIKLKLKD	CFAP70	1086	Q5T0N1
KKHPEKEMYVYQKDL	ANK3	2351	Q12955
KQKKKYMPYNHQHKY	FADS1	251	O60427
YVVKMYKHLKCKRDP	MALSU1	141	Q96EH3
GVKIHRGYKTKYKIM	DNA2	281	P51530
NYFKYTEKHKEMLPK	SCUBE3	961	Q8IX30
YEKMPESIKFIKQKH	IL1R1	496	P14778
DPFHLKYIIKKIKNM	MROH5	101	Q6ZUA9
IYTELKDPSKKKMQH	SLC38A3	306	Q99624
KPLKHKQVDEEKMYE	SCIMP	56	Q6UWF3
YDKAAKMYHQLKKCE	SMG5	256	Q9UPR3
LYKKMGKLDKAVPLY	NPHP3	1186	Q7Z494
KRHKGKYEMYLKVQP	ITIH3	161	Q06033
YKKNIKALYIVHPTM	ARHGAP1	151	Q07960
VKVDVEKQMPKKYEH	SRCAP	841	Q6ZRS2
SYSVMDSPKKLKHKL	THAP6	141	Q8TBB0
EPHIREMKIYIDKKY	SUPT16H	521	Q9Y5B9
DKIYHVTVMPCYDKK	CIAO3	236	Q9H6Q4
KYMKHLEDKYAEIKQ	CLHC1	181	Q8NHS4
SPDYKQAMEYKKKHS	C10orf120	116	Q5SQS8
EIKPLRKMEKSKSYY	CNNM2	176	Q9H8M5
YPVKEFEVYHKLMEK	CYP4Z1	61	Q86W10
KKHYFEVLMRKKLDP	SPG11	2181	Q96JI7
MLTDKYKQGKLHAYK	RALGAPA1	1136	Q6GYQ0
LKKYGQPIQMKYMEH	HSPA4L	681	O95757
KHTVLMQKYEEQKKY	STOX1	376	Q6ZVD7
PVYYQKLKHMVLDKM	POLR3B	1006	Q9NW08
KAKPYMTKEHLTKFI	PLCB2	231	Q00722
MPYNVKTHISKKYLK	ZNF347	226	Q96SE7
KKMTFPEKPSHKKYR	ZRSR2P1	11	Q15695
PEHVTAQKMKKAYYL	TTLL4	971	Q14679
DRHLYKMDPTKQYKV	MYO1D	881	O94832