Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetyl-CoA carboxylase activity	ACACA ACACB	4.97e-06	2	45	2	GO:0003989
GeneOntologyMolecularFunction	semaphorin receptor binding	SEMA6C SEMA3F SEMA4C	1.84e-05	23	45	3	GO:0030215
GeneOntologyMolecularFunction	GTPase activator activity	DOCK5 DEPDC1 RASA3 PREX1 SRGAP3 RGS12	3.63e-05	279	45	6	GO:0005096
GeneOntologyMolecularFunction	chemorepellent activity	SEMA6C SEMA3F SEMA4C	3.75e-05	29	45	3	GO:0045499
GeneOntologyMolecularFunction	CoA carboxylase activity	ACACA ACACB	7.41e-05	6	45	2	GO:0016421
GeneOntologyMolecularFunction	biotin binding	ACACA ACACB	7.41e-05	6	45	2	GO:0009374
GeneOntologyMolecularFunction	ligase activity, forming carbon-carbon bonds	ACACA ACACB	1.04e-04	7	45	2	GO:0016885
GeneOntologyMolecularFunction	molecular function activator activity	DOCK5 SEMA6C SEMA3F DEPDC1 RASA3 PREX1 SRGAP3 CWF19L1 RGS12 SEMA4C	3.40e-04	1233	45	10	GO:0140677
GeneOntologyMolecularFunction	enzyme activator activity	DOCK5 DEPDC1 RASA3 PREX1 SRGAP3 CWF19L1 RGS12	6.12e-04	656	45	7	GO:0008047
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK5 DEPDC1 RASA3 PREX1 SRGAP3 RGS12	9.14e-04	507	45	6	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK5 DEPDC1 RASA3 PREX1 SRGAP3 RGS12	9.14e-04	507	45	6	GO:0030695
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	GRIN2B RASA3	2.22e-03	31	45	2	GO:0099604
GeneOntologyBiologicalProcess	malonyl-CoA biosynthetic process	ACACA ACACB	4.87e-06	2	46	2	GO:2001295
GeneOntologyBiologicalProcess	malonyl-CoA metabolic process	ACACA ACACB	7.26e-05	6	46	2	GO:2001293
Domain	AcCoA_COase_cen	ACACA ACACB	5.93e-06	2	46	2	IPR013537
Domain	ACC_central	ACACA ACACB	5.93e-06	2	46	2	PF08326
Domain	Semaphorin	SEMA6C SEMA3F SEMA4C	1.55e-05	20	46	3	IPR027231
Domain	COA_CT_N	ACACA ACACB	3.55e-05	4	46	2	IPR011762
Domain	COA_CT_C	ACACA ACACB	3.55e-05	4	46	2	IPR011763
Domain	Carboxyl_trans	ACACA ACACB	3.55e-05	4	46	2	PF01039
Domain	COA_CT_CTER	ACACA ACACB	3.55e-05	4	46	2	PS50989
Domain	Carboxyl_trans	ACACA ACACB	3.55e-05	4	46	2	IPR000022
Domain	COA_CT_NTER	ACACA ACACB	3.55e-05	4	46	2	PS50980
Domain	Biotin_BS	ACACA ACACB	5.91e-05	5	46	2	IPR001882
Domain	Biotin_carb_C	ACACA ACACB	5.91e-05	5	46	2	SM00878
Domain	Biotin_carb_C	ACACA ACACB	5.91e-05	5	46	2	PF02785
Domain	Biotin_carboxylation_dom	ACACA ACACB	5.91e-05	5	46	2	IPR011764
Domain	CPSASE_1	ACACA ACACB	5.91e-05	5	46	2	PS00866
Domain	Biotin_COase_C	ACACA ACACB	5.91e-05	5	46	2	IPR005482
Domain	BIOTIN	ACACA ACACB	5.91e-05	5	46	2	PS00188
Domain	BC	ACACA ACACB	5.91e-05	5	46	2	PS50979
Domain	Sema	SEMA6C SEMA3F SEMA4C	5.99e-05	31	46	3	SM00630
Domain	Semap_dom	SEMA6C SEMA3F SEMA4C	5.99e-05	31	46	3	IPR001627
Domain	Sema	SEMA6C SEMA3F SEMA4C	5.99e-05	31	46	3	PF01403
Domain	SEMA	SEMA6C SEMA3F SEMA4C	5.99e-05	31	46	3	PS51004
Domain	CPSASE_2	ACACA ACACB	8.85e-05	6	46	2	PS00867
Domain	Rudment_hybrid_motif	ACACA ACACB	8.85e-05	6	46	2	IPR011054
Domain	CPSase_L_D2	ACACA ACACB	1.24e-04	7	46	2	PF02786
Domain	CbamoylP_synth_lsu-like_ATP-bd	ACACA ACACB	1.24e-04	7	46	2	IPR005479
Domain	BC-like_N	ACACA ACACB	1.24e-04	7	46	2	IPR005481
Domain	Biotin_carb_N	ACACA ACACB	1.24e-04	7	46	2	PF00289
Domain	PSI	SEMA6C SEMA3F SEMA4C	1.73e-04	44	46	3	IPR016201
Domain	PSI	SEMA6C SEMA3F SEMA4C	1.97e-04	46	46	3	SM00423
Domain	Biotin_lipoyl	ACACA ACACB	2.11e-04	9	46	2	PF00364
Domain	Biotin_lipoyl	ACACA ACACB	2.64e-04	10	46	2	IPR000089
Domain	BIOTINYL_LIPOYL	ACACA ACACB	2.64e-04	10	46	2	PS50968
Domain	-	PLEKHA2 NIBAN2 RASA3 PREX1 MTMR10 RGS12	3.74e-04	391	46	6	2.30.29.30
Domain	Single_hybrid_motif	ACACA ACACB	3.86e-04	12	46	2	IPR011053
Domain	-	ACACA ACACB	4.55e-04	13	46	2	3.40.50.20
Domain	ATP-grasp	ACACA ACACB	5.30e-04	14	46	2	IPR011761
Domain	PreATP-grasp_dom	ACACA ACACB	5.30e-04	14	46	2	IPR016185
Domain	ATP_GRASP	ACACA ACACB	5.30e-04	14	46	2	PS50975
Domain	PH_dom-like	PLEKHA2 NIBAN2 RASA3 PREX1 MTMR10 RGS12	5.88e-04	426	46	6	IPR011993
Domain	-	ACACA ACACB	6.11e-04	15	46	2	3.30.1490.20
Domain	ATP_grasp_subdomain_1	ACACA ACACB	8.85e-04	18	46	2	IPR013815
Domain	-	ACACA ACACB	8.85e-04	18	46	2	3.30.470.20
Domain	-	ACACA ACACB	1.21e-03	21	46	2	3.90.226.10
Domain	ClpP/crotonase-like_dom	ACACA ACACB	1.21e-03	21	46	2	IPR029045
Domain	Rho_GTPase_activation_prot	DEPDC1 RASA3 SRGAP3	1.33e-03	88	46	3	IPR008936
Domain	DEP	DEPDC1 PREX1	1.33e-03	22	46	2	PF00610
Domain	DEP	DEPDC1 PREX1	1.33e-03	22	46	2	PS50186
Domain	DEP	DEPDC1 PREX1	1.33e-03	22	46	2	SM00049
Domain	DEP_dom	DEPDC1 PREX1	1.45e-03	23	46	2	IPR000591
Domain	ATP_grasp_subdomain_2	ACACA ACACB	2.64e-03	31	46	2	IPR013816
Domain	PSI	SEMA6C SEMA4C	2.81e-03	32	46	2	PF01437
Domain	Plexin_repeat	SEMA6C SEMA4C	2.81e-03	32	46	2	IPR002165
Domain	UBIQUITIN_1	SACS TBCEL	3.74e-03	37	46	2	PS00299
Domain	PH	PLEKHA2 NIBAN2 RASA3 PREX1	4.80e-03	278	46	4	SM00233
Domain	PH_DOMAIN	PLEKHA2 NIBAN2 RASA3 PREX1	4.86e-03	279	46	4	PS50003
Domain	PH_domain	PLEKHA2 NIBAN2 RASA3 PREX1	4.92e-03	280	46	4	IPR001849
Pathway	REACTOME_CHREBP_ACTIVATES_METABOLIC_GENE_EXPRESSION	ACACA ACACB	1.57e-04	8	34	2	M26991
Pathway	WP_BIOTIN_METABOLISM_INCLUDING_IMDS	ACACA ACACB	2.01e-04	9	34	2	M40064
Pathway	KEGG_AXON_GUIDANCE	SEMA6C SEMA3F SRGAP3 SEMA4C	2.51e-04	129	34	4	M5539
Pathway	REACTOME_BIOTIN_TRANSPORT_AND_METABOLISM	ACACA ACACB	3.06e-04	11	34	2	M27086
Pathway	REACTOME_BIOTIN_TRANSPORT_AND_METABOLISM	ACACA ACACB	3.06e-04	11	34	2	MM14764
Pathway	WP_IL18_SIGNALING	SEMA6C GRIN2B MMP1 ACACB RASA3	4.61e-04	273	34	5	M39818
Pathway	REACTOME_CARNITINE_METABOLISM	ACACA ACACB	5.05e-04	14	34	2	M27098
Pathway	REACTOME_CARNITINE_METABOLISM	ACACA ACACB	5.05e-04	14	34	2	MM14788
Pubmed	De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.	ACACA ACACB	1.71e-06	2	46	2	25282359
Pubmed	Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.	ACACA ACACB	1.71e-06	2	46	2	27693630
Pubmed	AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis.	ACACA ACACB	1.71e-06	2	46	2	29433631
Pubmed	Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue.	ACACA ACACB	1.71e-06	2	46	2	32215608
Pubmed	Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.	ACACA ACACB	1.71e-06	2	46	2	29772612
Pubmed	Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin.	ACACA ACACB	1.71e-06	2	46	2	29976587
Pubmed	Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.	ACACA ACACB	1.71e-06	2	46	2	24944901
Pubmed	Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin.	ACACA ACACB	1.71e-06	2	46	2	36076520
Pubmed	AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation.	ACACA ACACB	1.71e-06	2	46	2	25001074
Pubmed	Structure and regulation of acetyl-CoA carboxylase genes of metazoa.	ACACA ACACB	1.71e-06	2	46	2	15749055
Pubmed	The subcellular localization of acetyl-CoA carboxylase 2.	ACACA ACACB	1.71e-06	2	46	2	10677481
Pubmed	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.	ACACA ACACB	1.71e-06	2	46	2	28290443
Pubmed	Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.	ACACA ACACB	1.71e-06	2	46	2	30244972
Pubmed	Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription.	ACACA ACACB	1.71e-06	2	46	2	20139635
Pubmed	Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.	ACACA ACACB	1.71e-06	2	46	2	28081256
Pubmed	Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2.	ACACA ACACB	1.71e-06	2	46	2	24338821
Pubmed	Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.	ACACA ACACB	1.71e-06	2	46	2	26976583
Pubmed	Neurites from trigeminal ganglion explants grown in vitro are repelled or attracted by tooth-related tissues depending on developmental stage.	SEMA6C SEMA3F SEMA4C	2.07e-06	19	46	3	15051154
Pubmed	Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity.	SEMA6C SEMA3F SEMA4C	2.83e-06	21	46	3	36240771
Pubmed	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	ACACA ACACB	5.13e-06	3	46	2	28877461
Pubmed	AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue.	ACACA ACACB	5.13e-06	3	46	2	34668531
Pubmed	Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.	ACACA ACACB	5.13e-06	3	46	2	20457939
Pubmed	AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.	ACACA ACACB	5.13e-06	3	46	2	30018077
Pubmed	Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.	ACACA ACACB	5.13e-06	3	46	2	36417534
Pubmed	Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas.	ACACA ACACB	5.13e-06	3	46	2	17521700
Pubmed	Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.	ACACA ACACB	5.13e-06	3	46	2	18455495
Pubmed	Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis.	ACACA ACACB	5.13e-06	3	46	2	31990961
Pubmed	The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.	ACACA ACACB	5.13e-06	3	46	2	27381369
Pubmed	Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice.	ACACA ACACB	5.13e-06	3	46	2	17210641
Pubmed	Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.	ACACA ACACB	5.13e-06	3	46	2	19846279
Pubmed	Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels.	ACACA ACACB	5.13e-06	3	46	2	18031993
Pubmed	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	ACACA ACACB	5.13e-06	3	46	2	28768177
Pubmed	Noggin is required for correct guidance of dorsal root ganglion axons.	SEMA6C SEMA3F SEMA4C	7.72e-06	29	46	3	12435358
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	DOCK5 CPNE8 NIBAN2 CLCN7 MTMR10 RGS12 SEMA4C	9.31e-06	569	46	7	30639242
Pubmed	Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.	ACACA ACACB	1.03e-05	4	46	2	24185692
Pubmed	Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.	ACACA ACACB	1.03e-05	4	46	2	38447582
Pubmed	Crystal structure of Spot 14, a modulator of fatty acid synthesis.	ACACA ACACB	1.03e-05	4	46	2	20952656
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA6C SEMA3F DISP2 ACACA CLCN7 RASA3 PREX1 POLE POLR2A	1.22e-05	1105	46	9	35748872
Pubmed	Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.	ACACA ACACB	1.71e-05	5	46	2	37163372
Pubmed	Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss.	ACACA ACACB	1.71e-05	5	46	2	32694673
Pubmed	TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.	ACACA ACACB	1.71e-05	5	46	2	16794074
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	PLEKHA2 NIBAN2 ACACA ACACB RASA3 SEMA4C	1.89e-05	421	46	6	36976175
Pubmed	Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum.	PRKAR2A GRIN2B	2.56e-05	6	46	2	25762721
Pubmed	TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.	SEMA6C SEMA3F SEMA4C	3.37e-05	47	46	3	35462405
Pubmed	Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling.	GRIN2B RASA3	3.58e-05	7	46	2	20661302
Pubmed	An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.	SEMA6C SEMA3F SEMA4C	4.57e-05	52	46	3	26633812
Pubmed	Genomic analysis of mouse retinal development.	SEMA3F PRKAR2A FTL TSPAN14 NXNL1 RASA3 SRGAP3 POLR2A	4.69e-05	1006	46	8	15226823
Pubmed	The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations.	ACACA ACACB	4.77e-05	8	46	2	36001969
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	DOCK5 MIEF1 DGCR8 ACACA ACACB GTF3C3 SEMA4C	6.78e-05	777	46	7	35844135
Pubmed	SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase.	ACACA ACACB	7.65e-05	10	46	2	19720090
Pubmed	HDAC1/NFκB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation.	ACACA ACACB	1.12e-04	12	46	2	21344388
Pubmed	AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress.	ACACA ACACB	1.12e-04	12	46	2	21436046
Pubmed	Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion.	DGCR8 GRIN2B	1.32e-04	13	46	2	23332760
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	CPNE8 NIBAN2 CLCN7 RASA3 MTMR10	1.39e-04	377	46	5	38117590
Pubmed	Balance between BDNF and Semaphorins gates the innervation of the mammary gland.	SEMA3F SEMA4C	2.03e-04	16	46	2	30628891
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	PLEKHA2 RERE ACACA ACACB GTF3C3	2.24e-04	418	46	5	34709266
Pubmed	Armc5 deletion causes developmental defects and compromises T-cell immune responses.	CDCA7L POLR2A	2.30e-04	17	46	2	28169274
Pubmed	Will diverse Tat interactions lead to novel antiretroviral drug targets?	PRKAR2A POLR2A	2.30e-04	17	46	2	17168834
Pubmed	Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.	ACACA ACACB PREX1	2.59e-04	93	46	3	27689697
Pubmed	Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development.	SEMA6C SEMA3F	3.20e-04	20	46	2	30819894
Pubmed	AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.	ACACA ACACB	3.54e-04	21	46	2	19217427
Pubmed	Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).	ACACA ACACB	3.89e-04	22	46	2	20965718
Pubmed	ATP-citrate lyase deficiency in the mouse.	ACACA ACACB	4.25e-04	23	46	2	14662765
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	MIEF1 CPNE8 TSPAN14 NRAP PREX1 MTMR10	4.43e-04	750	46	6	11230166
Pubmed	A semaphorin code defines subpopulations of spinal motor neurons during mouse development.	SEMA6C SEMA3F	4.64e-04	24	46	2	15869472
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	PRKAR2A GRIN2B SACS SRGAP3	5.21e-04	281	46	4	28706196
Pubmed	siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.	ACACA POLE	5.45e-04	26	46	2	23435420
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	PLEKHA2 CLCN7 SEMA4C	6.15e-04	125	46	3	29467281
Pubmed	Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.	SEMA3F SRGAP3	6.33e-04	28	46	2	18617019
Pubmed	WWP2 is an E3 ubiquitin ligase for PTEN.	ACACA ACACB	6.79e-04	29	46	2	21532586
Pubmed	Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals.	DGCR8 NRAP	8.28e-04	32	46	2	38110169
Pubmed	Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.	CPNE8 PDE11A	8.80e-04	33	46	2	23583979
Pubmed	Role of Tat protein in HIV neuropathogenesis.	GRIN2B POLR2A	8.80e-04	33	46	2	19526283
Pubmed	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	SEMA3F MARCHF10 RGS12	8.89e-04	142	46	3	19851296
Pubmed	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	SEMA3F MARCHF10 RGS12	9.08e-04	143	46	3	20198315
Pubmed	Inceptor counteracts insulin signalling in β-cells to control glycaemia.	ACACA ACACB	9.35e-04	34	46	2	33505018
Pubmed	LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.	ACACA ACACB	9.35e-04	34	46	2	26378152
Pubmed	The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.	POLE POLR2A	1.23e-03	39	46	2	9121429
Pubmed	A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells.	PRKAR2A TSPAN14	1.29e-03	40	46	2	17540781
Pubmed	Genome-scale RNAi screen for host factors required for HIV replication.	GRIN2B ACACB GTF3C3 POLE	1.32e-03	361	46	4	18976975
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA6C SEMA3F SEMA4C	4.15e-06	20	29	3	736
Coexpression	GSE14350_TREG_VS_TEFF_IN_IL2RB_KO_DN	PRKAR2A TMEM67 PLEKHA2 SRGAP3 POLE	2.55e-05	199	46	5	M3420
Coexpression	GSE15733_BM_VS_SPLEEN_MEMORY_CD4_TCELL_UP	SEMA6C SEMA3F GRIN2B MMP1 SRGAP3	2.62e-05	200	46	5	M3568
Coexpression	GSE34392_ST2_KO_VS_WT_DAY8_LCMV_EFFECTOR_CD8_TCELL_UP	CHST12 RERE RASA3 CDCA7L POLR2A	2.62e-05	200	46	5	M8653
Coexpression	GSE21546_WT_VS_SAP1A_KO_AND_ELK1_KO_DP_THYMOCYTES_DN	PLEKHA2 TSPAN14 NIBAN2 PREX1 SRGAP3	2.62e-05	200	46	5	M7518
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TMEM67 DNAH3 EFHC1 MARCHF10 SRGAP3 ZSCAN18	4.68e-08	193	46	6	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	TMEM67 DNAH3 EFHC1 MARCHF10 CDCA7L	1.48e-06	189	46	5	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	(0)_NK_cells-(0)_NK_FCGR3Apos\|(0)_NK_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	DOCK5 FTL TSPAN14 RASA3 MYO1F	1.86e-06	198	46	5	eba39656c6f699ab297b652ded8cb9727b49593c
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK5 FTL PREX1 MYO1F	5.10e-06	110	46	4	854f21560ce7cb5e1923403b6d04df3d804431e2
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH3 EFHC1 MARCHF10 SRGAP3	2.77e-05	169	46	4	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Penk_Col27a1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PLEKHA2 MARCHF10 CDCA7L	2.97e-05	58	46	3	ee9038695d11a428dc222962721bfdf11dd6954f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 DNAH3 GRIN2B SRGAP3	3.18e-05	175	46	4	9a96a946db731ba24c9be34bedebf1f4a1372b9e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 DNAH3 GRIN2B SRGAP3	3.18e-05	175	46	4	54c1f080195ad8392a095e83b56a4b54073d4c0d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 DNAH3 GRIN2B SRGAP3	3.18e-05	175	46	4	2b51406a2c2daa13ab4ed283ede038cd11d9e641
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCKAP5 DEPDC1 EFHC1 RGS12	3.47e-05	179	46	4	4166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCell	NS-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SEMA6C NCKAP5 MARCHF10 PDE11A	3.47e-05	179	46	4	65a96bee7bc28f5bfc20f0fd92bcc0ab2eb5e06c
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SEMA3F KLHL11 NRAP ACACB	3.95e-05	185	46	4	59acaf025353405948dc34ccccf37ec5c08ea903
ToppCell	Control-T_cells-NK_cells\|Control / group, cell type (main and fine annotations)	CHST12 RASA3 PREX1 MYO1F	3.95e-05	185	46	4	755c0998c729f462399f1d5e88adf4bfae31be30
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK5 NCKAP5 ACACB PREX1	4.20e-05	188	46	4	505b6b4277d7dea87aee27191d0acca67928b8e6
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH3 EFHC1 MARCHF10 PDE11A	4.29e-05	189	46	4	cd4746ea6ae48a7dd14a2960d38d9445a738cf2c
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK5 NCKAP5 ACACB PREX1	4.29e-05	189	46	4	784ace2be87f2ecb19490f4974f63a559516e0eb
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK5 NCKAP5 ACACB PREX1	4.29e-05	189	46	4	37ecbd73408d462b47d7e5611f203143e08a2689
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK5 NCKAP5 ACACB PREX1	4.38e-05	190	46	4	2de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCell	renal_medulla_nuclei-Adult_normal_reference\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	TSPAN14 RERE ACACA ACACB	4.38e-05	190	46	4	f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCell	Epithelial_cells-Ciliated_cells-B\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	TMEM67 DNAH3 EFHC1 MARCHF10	4.38e-05	190	46	4	426a4806f6e39d4d57c6746609d30bb3ca62df7d
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK5 FTL PREX1 MYO1F	4.47e-05	191	46	4	47156e5f1d790707f42f6283104a44b33af613e5
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK5 NCKAP5 ACACB PREX1	4.47e-05	191	46	4	f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK5 NCKAP5 ACACB PREX1	4.47e-05	191	46	4	a90c8ab2077e52bbc998457c85a1b9867f9c8c93
ToppCell	COPD-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	TMEM67 DNAH3 MARCHF10 CDCA7L	4.56e-05	192	46	4	eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	TMEM67 DNAH3 EFHC1 MARCHF10	4.56e-05	192	46	4	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	mild_COVID-19_(asymptomatic)-Non-classical_Monocyte\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	DOCK5 FTL TSPAN14 RGS12	4.65e-05	193	46	4	7839040e703877ef321494ad8926a8604729ceda
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	TMEM67 DNAH3 EFHC1 MARCHF10	4.65e-05	193	46	4	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SEMA3F CPNE8 GRIN2B MMP1	4.65e-05	193	46	4	84d1c1b7d3a1cb80f175527e3c89a2c3da7657f7
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SEMA3F CPNE8 GRIN2B MMP1	4.75e-05	194	46	4	efd5efed060edb7f24d59600981bb60ec28ac2ef
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM67 DNAH3 EFHC1 MARCHF10	4.75e-05	194	46	4	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	CF-Myeloid\|CF / Disease state, Lineage and Cell class	DOCK5 FTL PREX1 MYO1F	4.84e-05	195	46	4	ecf604de496f389a49429d0bb211e1db6019cc8b
ToppCell	control-Myeloid-Immature_Neutrophils_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	DEPDC1 SACS CDCA7L POLE	4.84e-05	195	46	4	bfaceb0601cf3855f38d6e1f482f01ad03ef11fe
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TMEM67 DNAH3 EFHC1 MARCHF10	4.84e-05	195	46	4	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	moderate-Epithelial-Ciliated\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TMEM67 DNAH3 EFHC1 MARCHF10	4.84e-05	195	46	4	e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell	control-Myeloid-Neutrophils_1\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	DOCK5 FTL PREX1 MYO1F	4.94e-05	196	46	4	9c8623232c47af5de9f360fd5c5113362e37c6c9
ToppCell	Influenza_Severe-Non-classical_Monocyte\|World / Disease group and Cell class	DOCK5 FTL TSPAN14 RGS12	4.94e-05	196	46	4	8ef9810ee99082a9c803c7ecad6ceb5710d16b54
ToppCell	critical-Epithelial-Ciliated\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TMEM67 DNAH3 EFHC1 MARCHF10	4.94e-05	196	46	4	27b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell	control-Others-Megakaryocytes\|Others / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	DOCK5 FTL PREX1 MYO1F	4.94e-05	196	46	4	10d914f1612622f64ac71da04e1995a854a4bec9
ToppCell	NS-control-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TMEM67 DNAH3 EFHC1 MARCHF10	4.94e-05	196	46	4	d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK5 PLEKHA2 FTL PREX1	4.94e-05	196	46	4	ff88e5b919b1be93159ad2200a7786d1c5272724
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TMEM67 DNAH3 EFHC1 MARCHF10	5.04e-05	197	46	4	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	NS-moderate-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TMEM67 DNAH3 EFHC1 MARCHF10	5.04e-05	197	46	4	71fea4aa6ce96c7693fa94792d08770622873850
ToppCell	T_cells-CTLs\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	CHST12 TSPAN14 RASA3 MYO1F	5.04e-05	197	46	4	28117cf300e169182571fbad0de1681a484a435a
ToppCell	T_cells-CTLs\|World / Immune cells in Kidney/Urine in Lupus Nephritis	CHST12 TSPAN14 RASA3 MYO1F	5.04e-05	197	46	4	2de34e20915a247bee75aa40495e23c20bb23e18
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TMEM67 DNAH3 EFHC1 MARCHF10	5.14e-05	198	46	4	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	Adult-Immune\|Adult / Lineage, Cell type, age group and donor	PLEKHA2 FTL PREX1 MYO1F	5.14e-05	198	46	4	9bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCell	PBMC-Control-cDC_0\|Control / Compartment, Disease Groups and Clusters	FTL TSPAN14 NIBAN2 MYO1F	5.24e-05	199	46	4	ebf03979ef56e978d72db475bb635b43b9cbe402
ToppCell	Biopsy_Control_(H.)-Epithelial-Ciliated\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	TMEM67 DNAH3 EFHC1 MARCHF10	5.34e-05	200	46	4	9ae434c78e08adf95da49c85616e3ca72d1227bf
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Ciliated\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	TMEM67 DNAH3 EFHC1 MARCHF10	5.34e-05	200	46	4	6a2ccc71a0cbe04a542c379b28b5006de53981c3
ToppCell	(08)_PNEC-(1)_24hpi\|(08)_PNEC / shred by cell type and Timepoint	ACACA PREX1	4.08e-04	29	46	2	f1b59a0b6bce5772bfb084f08507cf775e7eae8c
ToppCell	LPS-IL1RA-Endothelial-Mes-Like-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PLEKHA2 EFHC1 SACS	4.50e-04	145	46	3	90ca38c02325c5c637c32efdef634b54cc3cd105
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	ACACA CDCA7L GTF3C3	4.50e-04	145	46	3	80684ec249fa445c1b35f94608a4a6824d53f2d9
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIN2B POLE PDE11A	4.50e-04	145	46	3	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	ACACA CDCA7L GTF3C3	4.50e-04	145	46	3	cb534333fba44b241b14fb0d7b74e843f4e7f9f8
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DNAH3 MARCHF10 SACS	4.96e-04	150	46	3	53de595376a9fc92491dfd58ff25938b0bf79903
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DNAH3 MARCHF10 SACS	4.96e-04	150	46	3	e4b40b3243ed26d0c46bf196ac06e148834e7ed2
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr-Polydendrocyte.Tnr.Dlx1_(Dlx1)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DEPDC1 CDCA7L POLE	5.26e-04	153	46	3	d7635f3d4831c02a94f53afc674847d5b51453be
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DEPDC1 CDCA7L POLE	5.26e-04	153	46	3	54a941950bbb848077c7bd5726da9e4b3244bd38
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DEPDC1 CDCA7L POLE	5.26e-04	153	46	3	69a8550418ba0fc908a84b3b85761abb6e8ca4c0
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr-Polydendrocyte.Tnr.Dlx1_(Dlx1)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DEPDC1 CDCA7L POLE	5.26e-04	153	46	3	e50d20f9e553b8c3e10e187770d8abe1a43d109e
ToppCell	E18.5-samps-Endothelial-Mature_fetal_endothelial-capillary_endothelial_Hpgd-CA4_high\|E18.5-samps / Age Group, Lineage, Cell class and subclass	SEMA3F EFHC1 RGS12	5.36e-04	154	46	3	212c340a096a3a9669d1aebd61c045cf1402a868
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDCA7L POLE MYO1F	5.56e-04	156	46	3	33deda19f06172079ef1dd49fd54d66da1e7fb14
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DNAH3 SACS CDCA7L	5.56e-04	156	46	3	a5930b455e5c8586c43c50106ab4d8a1e5e9e3d6
ToppCell	facs-Spleen-nan-18m-Lymphocytic-NK_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PREX1 SEMA4C MYO1F	5.67e-04	157	46	3	a84377028c661f8f3ecae0f6082abdd859faf0c8
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACA MARCHF10 POLR2A	5.77e-04	158	46	3	1d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	TMEM67 MARCHF10 PDE11A	6.10e-04	161	46	3	58381131e651744b5141b202f9d6063f55432db5
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GRIN2B POLE PDE11A	6.21e-04	162	46	3	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	facs-Lung-nan-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK5 RASA3 MYO1F	6.21e-04	162	46	3	3fd6aaf0fbaffc7ab38aa25e46c37ef511e1e704
ToppCell	facs-Lung-nan-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK5 RASA3 MYO1F	6.21e-04	162	46	3	8134f73eb76693f4f1845f643042fdc1e81c274c
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-CD45____NK_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEPDC1 KCNA7 CDCA7L	6.21e-04	162	46	3	04a96442e0fcdb6a65b9e45044021677f9f53d38
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-CD4_CTL\|Multiple_Sclerosis / Disease, Lineage and Cell Type	CHST12 NXNL1 MYO1F	6.21e-04	162	46	3	d53de64df2511eddba79f899fc3f48b1b059923f
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-NK_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEPDC1 KCNA7 CDCA7L	6.21e-04	162	46	3	7adb3e279526e1f21033c10af0a0058258f21842
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-CD45____NK_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL11 CDCA7L MYO1F	6.32e-04	163	46	3	a763c1632d6465a1e753bdc8eadaf819d2b09e5e
ToppCell	facs-Lung-Endomucin-24m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK5 FTL MYO1F	6.32e-04	163	46	3	04152557aae230e9587fcc16cbabf1247cc5b419
ToppCell	facs-Lung-Endomucin-24m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK5 FTL MYO1F	6.32e-04	163	46	3	0644eb8a66d4e944063125c423de66d2393388b1
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-NK_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL11 CDCA7L MYO1F	6.32e-04	163	46	3	eaed783eecd07aafa5af844b63c9d816b4da99e4
ToppCell	356C-Lymphocytic-ILC-ILC-3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DOCK5 KLHL11 SRGAP3	6.32e-04	163	46	3	2dbdcbc4c187aad3db837d191cc78662a75dd0b5
ToppCell	tumor_Lung-T/NK_cells-Cytotoxic_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	CHST12 FTL MYO1F	6.43e-04	164	46	3	60fe6bb86afaebd92590135f08f5434ce0d8d73c
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DISP2 POLE SEMA4C	6.55e-04	165	46	3	62457b7b74c6eae42d91d65e7dc6df6bf8e061f7
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FTL NIBAN2 MMP1	6.66e-04	166	46	3	ce570b768988e30898cf0387c2aa99989631f13f
ToppCell	Sigmoid-Macrophage-Macrophage\|Macrophage / Region, Cell class and subclass	SRGAP3 RGS12 MYO1F	6.90e-04	168	46	3	bb16e135b6ae0d66615420b61edd6f62f2a3233c
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_C\|368C / Donor, Lineage, Cell class and subclass (all cells)	DOCK5 SRGAP3 TBCEL	6.90e-04	168	46	3	0372c06b70f0ba95bf8cd1363ca7c5f31207f094
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK5 FTL MYO1F	6.90e-04	168	46	3	4b5be7c6662eceddf90a65015f12908278d1664e
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK5 FTL MYO1F	6.90e-04	168	46	3	689c41f6e9f65381570991cc311cba49a57ec955
ToppCell	droplet-Spleen-nan-3m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FTL NXNL1 MYO1F	7.02e-04	169	46	3	91cfff1ad559cc327c6bb71c98aa29f0b3642568
ToppCell	facs-Marrow-KLS-24m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F SRGAP3 SEMA4C	7.02e-04	169	46	3	d6ad3b637de2935c656aad47ad82d6e8a8bd1227
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DEPDC1 CDCA7L POLE	7.02e-04	169	46	3	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	droplet-Lung-nan-3m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEPDC1 CDCA7L PDE11A	7.02e-04	169	46	3	df2c9c706bfc9db2bc5726602a49f5f5a94e9481
ToppCell	facs-Marrow-KLS-24m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F SRGAP3 SEMA4C	7.02e-04	169	46	3	60ef186518d0dc63dbded2a77c65cfe3129df754
ToppCell	droplet-Spleen-nan-3m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FTL NXNL1 MYO1F	7.02e-04	169	46	3	8e5e513090e86ca29fb61dfd388014774c506914
ToppCell	droplet-Lung-nan-3m-Lymphocytic-Proliferating_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEPDC1 CDCA7L PDE11A	7.02e-04	169	46	3	f6a6d2f614d60395ad9b867ff1cf59eba72b04ce
ToppCell	droplet-Lung-30m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SACS CDCA7L POLE	7.02e-04	169	46	3	822e5b6c1e55e196e6d2a38bf183fd220c45703e
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM67 DNAH3 EFHC1	7.02e-04	169	46	3	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	droplet-Spleen-nan-3m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FTL NXNL1 MYO1F	7.02e-04	169	46	3	972618e684321060c7af2429f853a6d639e8aae8
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KCNA7 CLCN7 MTMR10	7.14e-04	170	46	3	ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NCKAP5 NIBAN2 ACACA	7.14e-04	170	46	3	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SEMA6C DNAH3 EFHC1	7.26e-04	171	46	3	1854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell	368C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	TMEM67 POLE SEMA4C	7.26e-04	171	46	3	f3bf5805823d5733b58742172e7668725ce82931
ToppCell	T_cells-GNLY+GZMB+_T_cells\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	DOCK5 RASA3 MYO1F	7.26e-04	171	46	3	04c811817cfec45af5f2891793106cc7ddb0300e
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T\|bone_marrow / Manually curated celltypes from each tissue	SEMA3F CDCA7L POLE	7.39e-04	172	46	3	a66402d15853f0c9e3d06394ff9ac08d1da128ff
Drug	Myricetin [529-44-2]; Down 200; 12.6uM; MCF7; HT_HG-U133A	DOCK5 SEMA3F PLEKHA2 DGCR8 RERE CLCN7 TBCEL	1.22e-07	195	46	7	4170_DN
Drug	Rifampicin [13292-46-1]; Down 200; 4.8uM; MCF7; HT_HG-U133A	DOCK5 PRKAR2A DNAH3 RERE CWF19L1 RGS12	2.50e-06	194	46	6	4126_DN
Drug	Methyldopa (L,-) [555-30-6]; Down 200; 19uM; MCF7; HT_HG-U133A	PLEKHA2 DGCR8 RERE CLCN7 RGS12 MYO1F	2.81e-06	198	46	6	5272_DN
Drug	Cyclacillin [3485-14-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	SEMA3F DGCR8 CLCN7 RASA3 RGS12 MYO1F	2.81e-06	198	46	6	3882_DN
Drug	Muramic acid, N-acetyl [10597-89-4]; Down 200; 13.6uM; MCF7; HT_HG-U133A	PRKAR2A CLCN7 RASA3 CWF19L1 RGS12	3.89e-05	189	46	5	3262_DN
Drug	0317956-0000 [391210-11-0]; Up 200; 10uM; MCF7; HT_HG-U133A	SEMA3F DGCR8 CLCN7 RGS12 SEMA4C	4.40e-05	194	46	5	3855_UP
Drug	Methoxy-8-psoralen [298-81-7]; Down 200; 18.6uM; PC3; HT_HG-U133A	RERE ACACB CLCN7 TBCEL MYO1F	4.51e-05	195	46	5	6661_DN
Drug	Lobelanidine hydrochloride [6112-86-3]; Down 200; 10.6uM; MCF7; HT_HG-U133A	PRKAR2A DGCR8 RERE CLCN7 MYO1F	4.62e-05	196	46	5	2897_DN
Drug	Xylazine [7361-61-7]; Up 200; 18.2uM; PC3; HT_HG-U133A	KLHL11 PRKAR2A DGCR8 CLCN7 RASA3	4.62e-05	196	46	5	4066_UP
Drug	Bemegride [64-65-3]; Down 200; 25.8uM; MCF7; HT_HG-U133A	DOCK5 PLEKHA2 RERE RASA3 MYO1F	4.62e-05	196	46	5	3389_DN
Drug	Orphenadrine hydrochloride [341-69-5]; Down 200; 13uM; PC3; HT_HG-U133A	SEMA3F RERE RASA3 TBCEL SEMA4C	4.74e-05	197	46	5	3801_DN
Drug	Yohimbine hydrochloride [65-19-0]; Up 200; 10.2uM; MCF7; HT_HG-U133A	PLEKHA2 GRIN2B RGS12 POLR2A TBCEL	4.85e-05	198	46	5	6777_UP
Drug	PNU-0230031 [267429-39-0]; Down 200; 1uM; MCF7; HT_HG-U133A	SEMA3F PRKAR2A ACACB RGS12 MYO1F	4.85e-05	198	46	5	3632_DN
Drug	Fendiline hydrochloride [13636-18-5]; Down 200; 11.4uM; MCF7; HT_HG-U133A	SEMA3F PRKAR2A ACACB CWF19L1 RGS12	4.85e-05	198	46	5	3190_DN
Drug	6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one	ACACA ACACB	5.96e-05	6	46	2	ctd:C438505
Disease	muscular disease (implicated_via_orthology)	ACACA ACACB	2.27e-05	5	45	2	DOID:0080000 (implicated_via_orthology)
Disease	alcohol consumption measurement	SEMA3F PRKAR2A CPNE8 NCKAP5 GRIN2B RERE ACACA ACACB RGS12	9.08e-05	1242	45	9	EFO_0007878
Disease	physical activity measurement	CPNE8 RERE MARCHF10 RGS12	5.29e-04	245	45	4	EFO_0008002
Disease	blood rubidium measurement	NCKAP5 PREX1	7.22e-04	26	45	2	EFO_0021529
Disease	congestive heart failure (is_implicated_in)	PRKAR2A MMP1	7.79e-04	27	45	2	DOID:6000 (is_implicated_in)
Disease	proteinuria (implicated_via_orthology)	TMEM67 NCKAP5	9.63e-04	30	45	2	DOID:576 (implicated_via_orthology)
Disease	fatty liver disease (implicated_via_orthology)	ACACA ACACB	1.03e-03	31	45	2	DOID:9452 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FTFRARDKFEEDRIY	ACACA	1356	Q13085
DLEEFRSYLEKRFDF	DGCR8	436	Q8WYQ5
FERFDAEYRQLFLFE	DISP2	746	A7MBM2
LSFYIFDRDVFRRDS	RASA3	76	Q14644
DYDSSSVRKRFFREA	NIBAN2	481	Q96TA1
TFRARDEFAEDRIYR	ACACB	1476	O00763
ASDFRYKEAFLRDRG	NRAP	1546	Q86VF7
IYCKDFRIVRFRFDE	MTMR10	136	Q9NXD2
FFRELAEEKREGYER	FTL	51	P02792
LARRFRKDFEPYDFT	CWF19L1	521	Q69YN2
RDFKIFEYFRRDTEK	CLCN7	271	P51798
FEYFRRDTEKRDFVS	CLCN7	276	P51798
DLTLYFERRTEFFEL	PDE11A	776	Q9HCR9
FERDVFRTIADYFLD	DEPDC1	271	Q5TB30
AKFAEEFYSFRRRKT	CDCA7L	291	Q96GN5
DTVRAFRDRRYEFKG	POLE	756	Q07864
TDRDFYFASIRREFR	MIEF1	26	L0R8F8
RNAEERERYFEELFK	KLHL11	276	Q9NVR0
GRFYDDARREYFFDR	KCNA7	46	Q96RP8
FIYRGKEYERREDFS	DOCK5	1381	Q9H7D0
FYDRLIDKEDRQVFF	DNAH3	2311	Q8TD57
RFIECRYKEARAFFQ	FKTN	246	O75072
KASFRFRDEDFYSIL	MARCHF10	266	Q8NA82
PEDKDRRFVFSYFLA	EFHC1	431	Q5JVL4
EFAVEYFTRLREARA	PRKAR2A	31	P13861
IYEFLSAEKREFRFQ	SACS	3776	Q9NZJ4
DFVRKFILDYFFEER	CPNE8	76	Q86YQ8
FILDYFFEERENLRF	CPNE8	81	Q86YQ8
FAVFYERFIEDKIRQ	TMEM67	751	Q5HYA8
KRRFFALDDFTICYF	PLEKHA2	216	Q9HB19
DSAERNDDKLYFFFR	SEMA3F	266	Q13275
NDDKLYFFFRERSAE	SEMA3F	271	Q13275
ARDYTFFKRSEEDTE	NCKAP5	726	O14513
AYEFADRDEVRFFKG	MMP1	331	P03956
LEKSEFRDESQYFRF	PREX1	581	Q8TCU6
AREFKARVDSFFYIL	RERE	256	Q9P2R6
DDDKVYFFFRERAVE	SEMA4C	231	Q9C0C4
YLEGKISFEEFERRR	GTF3C3	11	Q9Y5Q9
RSKFELENEEFYRKF	CHST12	256	Q9NRB3
VRYFSDFLRKEFSEE	RGS12	726	O14924
DFFVRLTDEFYVLRA	NXNL1	56	Q96CM4
EFFRRKAEIELEYSR	SRGAP3	51	O43295
FEKKFRFDYTNERAL	POLR2A	916	P24928
VYFFFREVSVEDARL	SEMA6C	236	Q9H3T2
EFSRLRFREFVYQEA	ZSCAN18	46	Q8TBC5
DRFREFFESNIKSYR	TSPAN14	121	Q8NG11
EREDSERFFIRYYVD	TBCEL	296	Q5QJ74
RVDFADSVTKYDRRF	MYO1F	761	O00160
RYFRDKEGLRDFYLD	GRIN2B	1121	Q13224