Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alanine:sodium symporter activity	SLC38A2 SLC38A4	2.22e-05	4	39	2	GO:0015655
GeneOntologyMolecularFunction	neutral L-amino acid:sodium symporter activity	SLC38A2 SLC38A4	1.03e-04	8	39	2	GO:0005295
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	1.66e-04	10	39	2	GO:0001849
GeneOntologyMolecularFunction	alanine transmembrane transporter activity	SLC38A2 SLC38A4	4.38e-04	16	39	2	GO:0022858
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC38A2 SLC12A3 SLC38A4	5.29e-04	81	39	3	GO:0015370
GeneOntologyMolecularFunction	amino acid:sodium symporter activity	SLC38A2 SLC38A4	9.16e-04	23	39	2	GO:0005283
GeneOntologyMolecularFunction	opsonin binding	C4A C4B	1.08e-03	25	39	2	GO:0001846
GeneOntologyMolecularFunction	amino acid:monoatomic cation symporter activity	SLC38A2 SLC38A4	1.46e-03	29	39	2	GO:0005416
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC38A2 SLC12A3 SLC38A4	1.61e-03	119	39	3	GO:0015294
GeneOntologyMolecularFunction	complement binding	C4A C4B	1.78e-03	32	39	2	GO:0001848
GeneOntologyMolecularFunction	organic acid:sodium symporter activity	SLC38A2 SLC38A4	2.12e-03	35	39	2	GO:0005343
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC30A8 SLC38A2 SLC12A3 SLC38A4	2.59e-03	296	39	4	GO:0015291
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC30A8 SLC38A2 SLC12A3 SLC38A4	2.75e-03	301	39	4	GO:0022853
GeneOntologyMolecularFunction	neutral L-amino acid transmembrane transporter activity	SLC38A2 SLC38A4	2.90e-03	41	39	2	GO:0015175
GeneOntologyMolecularFunction	symporter activity	SLC38A2 SLC12A3 SLC38A4	3.11e-03	150	39	3	GO:0015293
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC38A2 SLC12A3 SLC38A4	4.50e-03	171	39	3	GO:0015081
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	9.92e-05	8	40	2	GO:0106139
GeneOntologyCellularComponent	other organism part	C4A C4B	1.27e-04	9	40	2	GO:0044217
Domain	RPAP3-like_C	SPAG1 RPAP3	1.34e-05	3	40	2	IPR025986
Domain	RPAP3_C	SPAG1 RPAP3	1.34e-05	3	40	2	PF13877
Domain	Anaphylatoxin_comp_syst	C4A C4B	4.45e-05	5	40	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	4.45e-05	5	40	2	IPR001840
Domain	ANATO	C4A C4B	9.33e-05	7	40	2	SM00104
Domain	ANATO	C4A C4B	9.33e-05	7	40	2	PF01821
Domain	ANAPHYLATOXIN_2	C4A C4B	9.33e-05	7	40	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	9.33e-05	7	40	2	PS01177
Domain	Anaphylatoxin/fibulin	C4A C4B	9.33e-05	7	40	2	IPR000020
Domain	Thiol-ester_cl	C4A C4B	1.24e-04	8	40	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	1.24e-04	8	40	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	1.24e-04	8	40	2	IPR019742
Domain	A2M_N	C4A C4B	1.99e-04	10	40	2	PF01835
Domain	A2M_N	C4A C4B	1.99e-04	10	40	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.99e-04	10	40	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.99e-04	10	40	2	PS00477
Domain	A2M	C4A C4B	1.99e-04	10	40	2	PF00207
Domain	A2M_N_2	C4A C4B	1.99e-04	10	40	2	IPR011625
Domain	A2M_comp	C4A C4B	1.99e-04	10	40	2	IPR011626
Domain	A2M_N_2	C4A C4B	1.99e-04	10	40	2	PF07703
Domain	A2M_recep	C4A C4B	1.99e-04	10	40	2	PF07677
Domain	A2M_comp	C4A C4B	1.99e-04	10	40	2	PF07678
Domain	Macroglobln_a2	C4A C4B	1.99e-04	10	40	2	IPR001599
Domain	Ras_G-nucl-exch_fac_CS	RASGEF1C RAPGEF5	4.00e-04	14	40	2	IPR019804
Domain	C345C	C4A C4B	5.96e-04	17	40	2	SM00643
Domain	Aa_trans	SLC38A2 SLC38A4	5.96e-04	17	40	2	PF01490
Domain	AA_transpt_TM	SLC38A2 SLC38A4	5.96e-04	17	40	2	IPR013057
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	6.70e-04	18	40	2	IPR008930
Domain	NTR	C4A C4B	7.47e-04	19	40	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	7.47e-04	19	40	2	IPR018933
Domain	RasGEF_N	RASGEF1C RAPGEF5	9.15e-04	21	40	2	PF00618
Domain	Ras-like_Gua-exchang_fac_N	RASGEF1C RAPGEF5	1.01e-03	22	40	2	IPR000651
Domain	RASGEF_NTER	RASGEF1C RAPGEF5	1.01e-03	22	40	2	PS50212
Domain	NTR	C4A C4B	1.10e-03	23	40	2	PS50189
Domain	Netrin_domain	C4A C4B	1.10e-03	23	40	2	IPR001134
Domain	RASGEF	RASGEF1C RAPGEF5	1.41e-03	26	40	2	PS00720
Domain	TIMP-like_OB-fold	C4A C4B	1.41e-03	26	40	2	IPR008993
Domain	RASGEF_CAT	RASGEF1C RAPGEF5	1.75e-03	29	40	2	PS50009
Domain	RasGEF	RASGEF1C RAPGEF5	1.87e-03	30	40	2	PF00617
Domain	-	RASGEF1C RAPGEF5	1.87e-03	30	40	2	1.10.840.10
Domain	Ras_GEF_dom	RASGEF1C RAPGEF5	1.87e-03	30	40	2	IPR023578
Domain	RASGEF_cat_dom	RASGEF1C RAPGEF5	1.87e-03	30	40	2	IPR001895
Domain	RasGEF	RASGEF1C RAPGEF5	1.87e-03	30	40	2	SM00147
Domain	TPR_8	SPAG1 RPAP3	5.75e-03	53	40	2	PF13181
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	4.42e-05	7	21	2	MM14685
Pathway	KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	5.89e-05	8	21	2	M47872
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	5.89e-05	8	21	2	M27031
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	1.15e-04	11	21	2	M47874
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	1.15e-04	11	21	2	MM1430
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	1.38e-04	12	21	2	MM1368
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	1.63e-04	13	21	2	M4732
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	2.19e-04	15	21	2	M7146
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C4A C4B	2.84e-04	17	21	2	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	2.84e-04	17	21	2	MM1369
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC30A8 SLC38A2 SLC12A3 SLC38A4	3.78e-04	238	21	4	MM15076
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	3.95e-04	20	21	2	M917
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC30A8 SLC38A2 SLC12A3 SLC38A4	4.49e-04	249	21	4	M5988
Pathway	WP_COMPLEMENT_ACTIVATION	C4A C4B	4.80e-04	22	21	2	M39502
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC38A2 SLC12A3 SLC38A4	5.26e-04	108	21	3	M823
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC38A2 SLC12A3 SLC38A4	5.40e-04	109	21	3	MM15074
Pathway	REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE	SLC38A2 SLC38A4	1.02e-03	32	21	2	MM14957
Pathway	REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE	SLC38A2 SLC38A4	1.09e-03	33	21	2	M188
Pathway	WP_OXIDATIVE_DAMAGE_RESPONSE	C4A C4B	1.76e-03	42	21	2	MM15945
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC30A8 SLC38A2 SLC12A3 SLC38A4 CYB5R1	2.76e-03	681	21	5	MM14985
Pathway	REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT	C4A C4B	2.89e-03	54	21	2	MM14655
Pathway	WP_SIDS_SUSCEPTIBILITY_PATHWAYS	C4A C4B	3.44e-03	59	21	2	MM15838
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC30A8 SLC38A2 SLC12A3 SLC38A4 CYB5R1	3.87e-03	736	21	5	M27287
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	C4A C4B	4.67e-03	69	21	2	M16894
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	1.36e-06	2	41	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	1.36e-06	2	41	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	1.36e-06	2	41	2	15998580
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	1.36e-06	2	41	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	1.36e-06	2	41	2	17728371
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	1.36e-06	2	41	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	1.36e-06	2	41	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	1.36e-06	2	41	2	3696167
Pubmed	Structure and organization of the C4 genes.	C4A C4B	1.36e-06	2	41	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	1.36e-06	2	41	2	6149581
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	1.36e-06	2	41	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	1.36e-06	2	41	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	1.36e-06	2	41	2	19933335
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	1.36e-06	2	41	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	1.36e-06	2	41	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	1.36e-06	2	41	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	1.36e-06	2	41	2	8132550
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	1.36e-06	2	41	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	1.36e-06	2	41	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	1.36e-06	2	41	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	1.36e-06	2	41	2	12207352
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	1.36e-06	2	41	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	1.36e-06	2	41	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	1.36e-06	2	41	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	1.36e-06	2	41	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	1.36e-06	2	41	2	16908004
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	1.36e-06	2	41	2	30026462
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	1.36e-06	2	41	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	1.36e-06	2	41	2	7365238
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	1.36e-06	2	41	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	1.36e-06	2	41	2	27758680
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	1.36e-06	2	41	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	1.36e-06	2	41	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	1.36e-06	2	41	2	17506029
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	1.36e-06	2	41	2	22387014
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	1.36e-06	2	41	2	17971360
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	1.36e-06	2	41	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	1.36e-06	2	41	2	20506482
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	1.36e-06	2	41	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	1.36e-06	2	41	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	1.36e-06	2	41	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	1.36e-06	2	41	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	1.36e-06	2	41	2	17971229
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	1.36e-06	2	41	2	12480675
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	1.36e-06	2	41	2	6881182
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	1.36e-06	2	41	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	1.36e-06	2	41	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	1.36e-06	2	41	2	23918728
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	1.36e-06	2	41	2	3944109
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	1.36e-06	2	41	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	1.36e-06	2	41	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	1.36e-06	2	41	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	1.36e-06	2	41	2	4216347
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	1.36e-06	2	41	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	1.36e-06	2	41	2	21880985
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	1.36e-06	2	41	2	1699796
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	1.36e-06	2	41	2	6978711
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	1.36e-06	2	41	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	1.36e-06	2	41	2	2997024
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	1.36e-06	2	41	2	35898513
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	1.36e-06	2	41	2	33353966
Pubmed	Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).	C4A C4B	1.36e-06	2	41	2	3008092
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	1.36e-06	2	41	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	1.36e-06	2	41	2	3624865
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	1.36e-06	2	41	2	28873507
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	1.36e-06	2	41	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	1.36e-06	2	41	2	21857912
Pubmed	The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.	C4A C4B	1.36e-06	2	41	2	6609966
Pubmed	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.	C4A C4B	1.36e-06	2	41	2	2900855
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	1.36e-06	2	41	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	1.36e-06	2	41	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	1.36e-06	2	41	2	4514997
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	1.36e-06	2	41	2	276882
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	1.36e-06	2	41	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	1.36e-06	2	41	2	5919331
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	1.36e-06	2	41	2	6832377
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	1.36e-06	2	41	2	3167981
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	1.36e-06	2	41	2	3794341
Pubmed	Complement and c4 null alleles in severe chronic adult periodontitis.	C4A C4B	1.36e-06	2	41	2	17257223
Pubmed	Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events.	C4A C4B	1.36e-06	2	41	2	2272665
Pubmed	Multiple C4/Slp genes distinguished by expression after transfection.	C4A C4B	1.36e-06	2	41	2	3023818
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	1.36e-06	2	41	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	1.36e-06	2	41	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	1.36e-06	2	41	2	2572548
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	1.36e-06	2	41	2	22785613
Pubmed	The complement component C4 of mammals.	C4A C4B	1.36e-06	2	41	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	1.36e-06	2	41	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	1.36e-06	2	41	2	34358307
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	1.36e-06	2	41	2	32691186
Pubmed	Genetic deficiency in complement component 4b does not alter radiation-induced lung disease in mice.	C4A C4B	1.36e-06	2	41	2	23259761
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	1.36e-06	2	41	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	1.36e-06	2	41	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	1.36e-06	2	41	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	1.36e-06	2	41	2	29080553
Pubmed	Lack of evidence of a specific role for C4A gene deficiency in determining disease susceptibility among C4-deficient patients with systemic lupus erythematosus (SLE).	C4A C4B	1.36e-06	2	41	2	11168010
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	1.36e-06	2	41	2	8390682
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	1.36e-06	2	41	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	1.36e-06	2	41	2	6589636
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	1.36e-06	2	41	2	3902619
Pubmed	Genetic polymorphism of murine C3 controlled by a single co-dominant locus on chromosome 17.	C4A C4B	4.06e-06	3	41	2	681746
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	PRKAG1 SLC38A2 RPAP3 SLC38A4	5.50e-04	423	41	4	chr12q13
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	C4A C4B ABO	2.23e-05	37	27	3	454
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	7.68e-05	9	27	2	1234
GeneFamily	Complement system\|Sushi domain containing	C4A C4B	1.31e-03	36	27	2	492
GeneFamily	Solute carriers	SLC30A8 SLC38A2 SLC12A3 SLC38A4	2.64e-03	395	27	4	752
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	SPAG1 RPAP3	1.27e-02	115	27	2	769
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MPP3 PIEZO2 SAMD3 ADAMTS6 RAPGEF5	4.08e-07	164	41	5	b6df1e67a5ce5f2d86f4e1420f4ee931f760bf4d
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLN2 CFAP91 ANKRD22 SLC38A4	1.37e-05	159	41	4	7619d0d49738dd08daf01b42664691a5323aa793
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLN2 CFAP91 ANKRD22 SLC38A4	1.37e-05	159	41	4	4000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TLN2 CFAP91 ANKRD22 SLC38A4	1.63e-05	166	41	4	5e3b998d740b24f790fad37350d704ca0ea10b77
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TLN2 CFAP91 ANKRD22 SLC38A4	1.63e-05	166	41	4	bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 SAMD3 ADAMTS6 RAPGEF5	1.87e-05	172	41	4	553701349444eb366df3c11f54bb093434f153c6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 SAMD3 ADAMTS6 RAPGEF5	1.87e-05	172	41	4	08a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLN2 PIEZO2 LOXHD1 PTPRD	2.44e-05	184	41	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLN2 PIEZO2 LOXHD1 PTPRD	2.44e-05	184	41	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLN2 PIEZO2 LOXHD1 PTPRD	2.44e-05	184	41	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC30A8 DPP10 PTPRD SLC38A4	2.54e-05	186	41	4	4bb54043f944a979db91bde9a86dd66f498c7658
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 SAMD3 ADAMTS6 RAPGEF5	2.59e-05	187	41	4	15d6e158562d7d85af3ceaf955439b379c8fce81
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 SAMD3 ADAMTS6 RAPGEF5	2.59e-05	187	41	4	f62074b631fd45ad299c69d71b09267b04d656ee
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3-Excitatory_Neuron.Slc17a7.Pvrl3-Fos_(CA3_Principal_cells)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SLC30A8 LOXHD1 SLC38A4	5.50e-05	80	41	3	b661644806e225f215047e78ae46d7cee6efde4f
ToppCell	lymphoid-T_cell-pro-T_cell\|World / Lineage, cell class and subclass	SLC38A2 SORCS3 TTPAL	5.50e-05	80	41	3	9bd3ad5029eb84efcdbf08fe268c29fa9b0b302b
Drug	2-aminothiophenol	C4A C4B	9.48e-06	3	41	2	ctd:C005464
Disease	cholesteryl esters to total lipids in large VLDL percentage	MPP3 TDRD15 ABO	5.64e-05	56	39	3	EFO_0022250
Disease	free cholesterol measurement, high density lipoprotein cholesterol measurement	MPP3 TDRD15 ABO SLC12A3 MYO1H	5.74e-05	315	39	5	EFO_0004612, EFO_0008591
Disease	free cholesterol to total lipids in very large VLDL percentage	MPP3 TDRD15 ABO	6.59e-05	59	39	3	EFO_0022289
Disease	total lipids in small VLDL	MPP3 TDRD15 ABO	9.64e-05	67	39	3	EFO_0022148
Disease	lipoprotein measurement, phospholipid measurement	TDRD15 ABO MYO1H	1.96e-04	85	39	3	EFO_0004639, EFO_0004732
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	MPP3 TDRD15 ABO	2.02e-04	86	39	3	EFO_0008595, EFO_0020945
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	TDRD15 ABO	2.29e-04	17	39	2	EFO_0022232
Disease	triglyceride measurement, alcohol consumption measurement	MPP3 TDRD15 ABO	3.25e-04	101	39	3	EFO_0004530, EFO_0007878
Disease	lipoprotein measurement	TDRD15 ABO MYO1H	3.65e-04	105	39	3	EFO_0004732
Disease	inflammatory biomarker measurement	PIEZO2 ABO	5.42e-04	26	39	2	EFO_0004872
Disease	cholesterol to total lipids in medium LDL percentage	TDRD15 ABO	5.85e-04	27	39	2	EFO_0022238
Disease	non-alcoholic fatty liver disease severity measurement	SORCS3 PTPRD	6.30e-04	28	39	2	EFO_0008421
Disease	choline measurement	TDRD15 ABO MYO1H	6.80e-04	130	39	3	EFO_0010116
Disease	blood viscosity	RASGEF1C PTPRD	7.73e-04	31	39	2	EFO_0004301
Disease	total cholesterol measurement, high density lipoprotein cholesterol measurement	MPP3 TDRD15 ABO MYO1H	7.81e-04	315	39	4	EFO_0004574, EFO_0004612
Disease	phospholipid measurement, high density lipoprotein cholesterol measurement	MPP3 TDRD15 ABO MYO1H	8.37e-04	321	39	4	EFO_0004612, EFO_0004639
Disease	phospholipid measurement	TDRD15 ABO MYO1H	8.43e-04	140	39	3	EFO_0004639
Disease	Complement deficiency disease	C4A C4B	8.76e-04	33	39	2	C0272242
Disease	lipid measurement, high density lipoprotein cholesterol measurement	MPP3 TDRD15 ABO MYO1H	9.28e-04	330	39	4	EFO_0004529, EFO_0004612
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	TDRD15 ABO	9.30e-04	34	39	2	EFO_0008317, EFO_0008596, EFO_0020944
Disease	free cholesterol in small HDL measurement	TDRD15 ABO	9.85e-04	35	39	2	EFO_0022270
Disease	diabetic nephropathy	SORCS3 RAPGEF5 RBL1	1.03e-03	150	39	3	EFO_0000401
Disease	free cholesterol to total lipids in large VLDL percentage	TDRD15 ABO	1.10e-03	37	39	2	EFO_0022281
Disease	Graves' disease (is_implicated_in)	C4A C4B	1.22e-03	39	39	2	DOID:12361 (is_implicated_in)
Disease	aspirin use measurement	TDRD15 ABO	1.22e-03	39	39	2	EFO_0007013
Disease	cholesterol in very small VLDL measurement	TDRD15 ABO	1.29e-03	40	39	2	EFO_0022231
Disease	free cholesterol in medium LDL measurement	TDRD15 ABO	1.29e-03	40	39	2	EFO_0022268
Disease	factor VIII measurement	SLC38A2 ABO	1.29e-03	40	39	2	EFO_0004630

Protein segments in the cluster

Peptide	Gene	Start	Entry
RILKFLKLFITEFPK	PRKAG1	171	P54619
FAIKKYVAFLKLFLE	ABO	121	P16442
FEVKKYVLPNFEVKI	C4B	231	P0C0L5
FYKVIPKSKFVLVKF	ERP29	46	P30040
VKKKFTFIDYLLIIL	ANKRD22	81	Q5VYY1
VKFLLKLPYIDSKRL	DPP10	631	Q8N608
VNKVAYCPLVLKFKF	ADAMTS6	1086	Q9UKP5
FLIPEVQKYFVKEKV	CFAP91	701	Q7Z4T9
LFKKEILETKAPYRI	HSFY1	111	Q96LI6
VIKYKDYFPVILKRA	MAGEC2	171	Q9UBF1
FKKYLARKILDFKLP	NLRP11	26	P59045
LIPLKRKRKYFKVFE	LOXHD1	1916	Q8IVV2
VYKILEPEALKFFKI	FAT2	1801	Q9NYQ8
LVFVLLLVKRFIPKY	NEMP2	191	A6NFY4
FTVLEKFRYLPKAIK	LAS1L	281	Q9Y4W2
KDEVYQKIILKFPLL	PASD1	86	Q8IV76
KLILLEKKVLFYISP	AVL9	196	Q8NBF6
LFILPFVSVAKEKKY	POLQ	141	O75417
FEVKKYVLPNFEVKI	C4A	231	P0C0L4
YIIIVPLKKSRGKFI	PTPRD	1141	P23468
FKPYIIFVKPAIQEK	MPP3	496	Q13368
FKISKIYKPLLFMDL	UTP4	641	Q969X6
YVKKLKQDFILVPLF	TDRD15	336	B5MCY1
FKPYISKLFDRKILK	RBL1	271	P28749
VGLAVFLIYKFKRKI	SORCS3	1136	Q9UPU3
LKDILKLFPFLKCPY	SAMD3	326	Q8N6K7
YPILEKELKEFQKIL	RAPGEF5	186	Q92565
PYKVDPFVIIIKFLL	PGAP1	636	Q75T13
FILPAVFYLKLVKKE	SLC38A4	491	Q969I6
DLVIKVYLKGVHPKF	CYB5R1	111	Q9UHQ9
IFKGIFAIIKPFLKE	TTPAL	231	Q9BTX7
VLISALIIYFKPEYK	SLC30A8	231	Q8IWU4
FYIEKEKPLLIFEIL	RPAP3	601	Q9H6T3
FILPSAFYIKLVKKE	SLC38A2	451	Q96QD8
KIVIPFFSLLIKDIY	RASGEF1C	361	Q8N431
KTFKIPIEHLDFKYI	SPAG1	16	Q07617
IKKTLEIYVPIKQFF	PIEZO2	2161	Q9H5I5
VLFLLLYVIYKKPEV	SLC12A3	596	P55017
FLDLKEFLPKEYIKQ	TLN2	261	Q9Y4G6
KLEPFQKELYKEVLL	ZNF483	186	Q8TF39
EEYKLGKTKIFIRFP	MYO1H	676	Q8N1T3