Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Notch	NOTCH1 NOTCH4	8.27e-05	4	70	2	IPR008297
Domain	NODP	NOTCH1 NOTCH4	8.27e-05	4	70	2	PF07684
Domain	Notch_NODP_dom	NOTCH1 NOTCH4	8.27e-05	4	70	2	IPR011656
Domain	Notch_NOD_dom	NOTCH1 NOTCH4	8.27e-05	4	70	2	IPR010660
Domain	DUF1908	MAST2 MAST3	8.27e-05	4	70	2	PF08926
Domain	NOD	NOTCH1 NOTCH4	8.27e-05	4	70	2	PF06816
Domain	MA_Ser/Thr_Kinase_dom	MAST2 MAST3	8.27e-05	4	70	2	IPR015022
Domain	MAST_pre-PK_dom	MAST2 MAST3	8.27e-05	4	70	2	IPR023142
Domain	NOD	NOTCH1 NOTCH4	8.27e-05	4	70	2	SM01338
Domain	NODP	NOTCH1 NOTCH4	8.27e-05	4	70	2	SM01339
Domain	-	MAST2 MAST3	8.27e-05	4	70	2	1.20.1480.20
Domain	LNR	NOTCH1 NOTCH4	1.37e-04	5	70	2	PS50258
Domain	Notch_dom	NOTCH1 NOTCH4	2.87e-04	7	70	2	IPR000800
Domain	Notch	NOTCH1 NOTCH4	2.87e-04	7	70	2	PF00066
Domain	NL	NOTCH1 NOTCH4	2.87e-04	7	70	2	SM00004
Domain	MKP	DUSP16 DUSP8	6.11e-04	10	70	2	IPR008343
Domain	Pept_M10A_Zn_BS	MMP2 MMP11	1.41e-03	15	70	2	IPR021158
Domain	Laminin_N	LAMA5 USH2A	1.61e-03	16	70	2	IPR008211
Domain	LAMININ_NTER	LAMA5 USH2A	1.61e-03	16	70	2	PS51117
Domain	Laminin_N	LAMA5 USH2A	1.61e-03	16	70	2	PF00055
Domain	LamNT	LAMA5 USH2A	1.61e-03	16	70	2	SM00136
Domain	Hemopexin_CS	MMP2 MMP11	1.82e-03	17	70	2	IPR018486
Domain	Growth_fac_rcpt_	LAMA5 NOTCH1 NOTCH4 EPHA1	2.80e-03	156	70	4	IPR009030
Domain	EPHD	KMT2D G2E3	3.05e-03	22	70	2	PS51805
Domain	RHOD	DUSP16 DUSP8	3.05e-03	22	70	2	SM00450
Domain	Hemopexin-like_dom	MMP2 MMP11	3.33e-03	23	70	2	IPR000585
Domain	Hemopexin-like_repeat	MMP2 MMP11	3.33e-03	23	70	2	IPR018487
Domain	M10A_MMP	MMP2 MMP11	3.33e-03	23	70	2	IPR033739
Domain	RHODANESE_3	DUSP16 DUSP8	3.33e-03	23	70	2	PS50206
Domain	Hemopexin	MMP2 MMP11	3.33e-03	23	70	2	PF00045
Domain	HEMOPEXIN	MMP2 MMP11	3.33e-03	23	70	2	PS00024
Domain	-	MMP2 MMP11	3.33e-03	23	70	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP2 MMP11	3.33e-03	23	70	2	PS51642
Domain	HX	MMP2 MMP11	3.33e-03	23	70	2	SM00120
Domain	Pept_M10A	MMP2 MMP11	3.33e-03	23	70	2	IPR021190
Domain	Rhodanese-like_dom	DUSP16 DUSP8	3.62e-03	24	70	2	IPR001763
Domain	Rhodanese	DUSP16 DUSP8	3.62e-03	24	70	2	PF00581
Domain	Peptidase_M10	MMP2 MMP11	3.62e-03	24	70	2	PF00413
Domain	-	DUSP16 DUSP8	3.62e-03	24	70	2	3.40.250.10
Domain	hEGF	NOTCH1 NOTCH4	4.91e-03	28	70	2	PF12661
Domain	HRM	ADGRB2 ADGRF3	4.91e-03	28	70	2	PF02793
Domain	ZnMc	MMP2 MMP11	5.27e-03	29	70	2	SM00235
Domain	Peptidase_Metallo	MMP2 MMP11	5.27e-03	29	70	2	IPR006026
Domain	-	LAMA5 WDFY3 USH2A	5.46e-03	95	70	3	2.60.120.200
Domain	EGF_LAM_2	LAMA5 USH2A	5.63e-03	30	70	2	PS50027
Domain	EGF_LAM_1	LAMA5 USH2A	5.63e-03	30	70	2	PS01248
Domain	DUSP	DUSP16 DUSP8	6.00e-03	31	70	2	IPR024950
Pathway	REACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3	NOTCH1 NOTCH4	1.33e-04	5	52	2	M27411
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI	NOTCH1 NOTCH4	1.33e-04	5	52	2	MM14733
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM	NOTCH1 NOTCH4	1.98e-04	6	52	2	M27068
Pathway	REACTOME_SIGNALING_BY_MAPK_MUTANTS	DUSP16 DUSP8	2.77e-04	7	52	2	M38997
Pathway	REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING	NOTCH1 NOTCH4	2.77e-04	7	52	2	MM14734
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DPH2 KMT2D VWA8 NLRX1 DUSP16 ADGRB2 LAMA5 ZFPM1 WDFY3 MAST2 NOTCH1 MAP3K5	2.64e-06	1105	72	12	35748872
Pubmed	Introduction to Notch signaling.	NOTCH1 NOTCH4	4.23e-06	2	72	2	25053477
Pubmed	Differential patterns of NOTCH1-4 receptor expression are markers of glioma cell differentiation.	NOTCH1 NOTCH4	4.23e-06	2	72	2	24305720
Pubmed	Notch signaling in cancer.	NOTCH1 NOTCH4	4.23e-06	2	72	2	12496471
Pubmed	Inhibition of Notch pathway attenuates the progression of human immunodeficiency virus-associated nephropathy.	NOTCH1 NOTCH4	4.23e-06	2	72	2	23389453
Pubmed	Notch signaling: from the outside in.	NOTCH1 NOTCH4	4.23e-06	2	72	2	11112321
Pubmed	Clinicopathological significance of aberrant Notch receptors in intrahepatic cholangiocarcinoma.	NOTCH1 NOTCH4	4.23e-06	2	72	2	25031748
Pubmed	Thymosin beta4 induces angiogenesis through Notch signaling in endothelial cells.	NOTCH1 NOTCH4	4.23e-06	2	72	2	23749167
Pubmed	Notch1 modulates oxidative stress induced cell death through suppression of apoptosis signal-regulating kinase 1.	NOTCH1 MAP3K5	4.23e-06	2	72	2	23569274
Pubmed	MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions.	MAST2 NOTCH1	4.23e-06	2	72	2	24140425
Pubmed	Crosstalk between TLR5 and Notch1 signaling in epithelial cells during intestinal inflammation.	TLR5 NOTCH1	4.23e-06	2	72	2	24048326
Pubmed	Critical role of endothelial Notch1 signaling in postnatal angiogenesis.	NOTCH1 NOTCH4	4.23e-06	2	72	2	17158336
Pubmed	Notch-1 and Notch-4 biomarker expression in triple-negative breast cancer.	NOTCH1 NOTCH4	4.23e-06	2	72	2	22084425
Pubmed	Notch-1 and notch-4 receptors as prognostic markers in breast cancer.	NOTCH1 NOTCH4	4.23e-06	2	72	2	20444726
Pubmed	In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis in the chick chorioallantoic model.	WNT9A NOTCH1	4.23e-06	2	72	2	27117272
Pubmed	Notch1 and Notch4 are markers for poor prognosis of hepatocellular carcinoma.	NOTCH1 NOTCH4	4.23e-06	2	72	2	23742774
Pubmed	Role of immunohistochemical overexpression of matrix metalloproteinases MMP-2 and MMP-11 in the prognosis of death by ovarian cancer.	MMP2 MMP11	4.23e-06	2	72	2	18208802
Pubmed	Results in treatment of early breast cancers and the level of selected metalloproteinases.	MMP2 MMP11	4.23e-06	2	72	2	22286800
Pubmed	In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy.	MMP2 MMP11	4.23e-06	2	72	2	9508784
Pubmed	Hepatitis B virus X protein activates Notch signaling by its effects on Notch1 and Notch4 in human hepatocellular carcinoma.	NOTCH1 NOTCH4	4.23e-06	2	72	2	26530164
Pubmed	Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis.	MMP2 NOTCH1 NOTCH4	1.10e-05	21	72	3	22932696
Pubmed	Notch transcriptional target tmtc1 maintains vascular homeostasis.	TMTC1 NOTCH1	1.27e-05	3	72	2	39190102
Pubmed	Notch receptor expression in human brain arteriovenous malformations.	NOTCH1 NOTCH4	1.27e-05	3	72	2	25846406
Pubmed	Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.	MAST2 NOTCH1	1.27e-05	3	72	2	22101766
Pubmed	Recurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas.	KMT2D NOTCH1	1.27e-05	3	72	2	27566587
Pubmed	Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches.	NOTCH1 NOTCH4	1.27e-05	3	72	2	18593923
Pubmed	Characterization of Notch Signalling Pathway Members in Normal Prostate, Prostatic Intraepithelial Neoplasia (PIN) and Prostatic Adenocarcinoma.	NOTCH1 NOTCH4	1.27e-05	3	72	2	26341090
Pubmed	Differential expression of Notch genes in human osteoblastic cells.	NOTCH1 NOTCH4	1.27e-05	3	72	2	11836628
Pubmed	Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation.	NOTCH1 NOTCH4	1.27e-05	3	72	2	14988227
Pubmed	Delta-like 4/Notch pathway is differentially regulated in benign and malignant thyroid tissues.	NOTCH1 NOTCH4	1.27e-05	3	72	2	22066479
Pubmed	Unique patterns of Notch1, Notch4 and Jagged1 expression in ovarian vessels during folliculogenesis and corpus luteum formation.	NOTCH1 NOTCH4	1.27e-05	3	72	2	15939383
Pubmed	Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease.	NOTCH1 NOTCH4	1.27e-05	3	72	2	19546852
Pubmed	[Expression of Notch1, MMP-2 and MMP-9 and their significance in glioma patients].	MMP2 NOTCH1	1.27e-05	3	72	2	22490851
Pubmed	Notch1 signaling pathway participates in cancer invasion by regulating MMPs in lingual squamous cell carcinoma.	MMP2 NOTCH1	1.27e-05	3	72	2	21993452
Pubmed	NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications.	NOTCH1 NOTCH4	1.27e-05	3	72	2	21679465
Pubmed	Notch signaling: cell fate control and signal integration in development.	NOTCH1 NOTCH4	1.27e-05	3	72	2	10221902
Pubmed	Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.	NOTCH1 NOTCH4	1.27e-05	3	72	2	28871079
Pubmed	Notch1 is pan-endothelial at the onset of flow and regulated by flow.	NOTCH1 NOTCH4	1.27e-05	3	72	2	25830332
Pubmed	Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.	NOTCH1 NOTCH4	2.53e-05	4	72	2	28061457
Pubmed	The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.	NOTCH1 NOTCH4	2.53e-05	4	72	2	24145721
Pubmed	A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.	NOTCH1 NOTCH4	2.53e-05	4	72	2	20069356
Pubmed	ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds.	NOTCH1 NOTCH4	2.53e-05	4	72	2	27354212
Pubmed	Expression and clinical significance of Notch receptors in human renal cell carcinoma.	NOTCH1 NOTCH4	2.53e-05	4	72	2	19404845
Pubmed	Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.	NOTCH1 NOTCH4	2.53e-05	4	72	2	28669409
Pubmed	Evolutionary analysis of vertebrate Notch genes.	NOTCH1 NOTCH4	2.53e-05	4	72	2	11466531
Pubmed	Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.	NOTCH1 NOTCH4	2.53e-05	4	72	2	24151014
Pubmed	Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.	NOTCH1 NOTCH4	2.53e-05	4	72	2	17984306
Pubmed	Utility of molecular testing for related retinal dystrophies.	USH2A RHO	2.53e-05	4	72	2	16767206
Pubmed	Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.	NOTCH1 NOTCH4	2.53e-05	4	72	2	11401408
Pubmed	Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.	NOTCH1 NOTCH4	2.53e-05	4	72	2	10194420
Pubmed	Functional conservation of mouse Notch receptor family members.	NOTCH1 NOTCH4	2.53e-05	4	72	2	8898100
Pubmed	Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases.	MAST2 MAST3	2.53e-05	4	72	2	15951562
Pubmed	Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties.	NOTCH1 NOTCH4	2.53e-05	4	72	2	36376768
Pubmed	Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.	NOTCH1 NOTCH4	2.53e-05	4	72	2	11459941
Pubmed	Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages.	NOTCH1 NOTCH4	2.53e-05	4	72	2	20739676
Pubmed	Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.	NOTCH1 NOTCH4	2.53e-05	4	72	2	18184405
Pubmed	Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer.	NOTCH1 NOTCH4	2.53e-05	4	72	2	35543859
Pubmed	Notch signaling in the mammalian central nervous system: insights from mouse mutants.	NOTCH1 NOTCH4	2.53e-05	4	72	2	15917835
Pubmed	Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.	NOTCH1 NOTCH4	2.53e-05	4	72	2	23444212
Pubmed	Deregulated expression of Notch receptors in human hepatocellular carcinoma.	NOTCH1 NOTCH4	2.53e-05	4	72	2	17920003
Pubmed	Focal MMP-2 and MMP-9 activity at the blood-brain barrier promotes chemokine-induced leukocyte migration.	MMP2 NOTCH1	4.21e-05	5	72	2	25704809
Pubmed	Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL.	NOTCH1 NOTCH4	4.21e-05	5	72	2	21124806
Pubmed	Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).	NOTCH1 NOTCH4	4.21e-05	5	72	2	23675950
Pubmed	MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.	NOTCH1 NOTCH4	4.21e-05	5	72	2	11101851
Pubmed	Deubiquitinase USP10 regulates Notch signaling in the endothelium.	USP10 NOTCH1	4.21e-05	5	72	2	30975888
Pubmed	Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.	NOTCH1 NOTCH4	4.21e-05	5	72	2	15882997
Pubmed	Association of Notch pathway down-regulation with Triple Negative/Basal-like breast carcinomas and high tumor-infiltrating FOXP3+ Tregs.	NOTCH1 NOTCH4	4.21e-05	5	72	2	27118257
Pubmed	Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.	FOXO4 NOTCH1	4.21e-05	5	72	2	21653327
Pubmed	Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1.	NOTCH1 NOTCH4	4.21e-05	5	72	2	20554499
Pubmed	RBP-L, a transcription factor related to RBP-Jkappa.	NOTCH1 NOTCH4	6.31e-05	6	72	2	9111338
Pubmed	Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.	NOTCH1 NOTCH4	6.31e-05	6	72	2	20870902
Pubmed	A study on Notch signaling in human breast cancer.	NOTCH1 NOTCH4	6.31e-05	6	72	2	17822320
Pubmed	Characterization of Notch receptor expression in the developing mammalian heart and liver.	NOTCH1 NOTCH4	6.31e-05	6	72	2	12244553
Pubmed	Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site.	NOTCH1 NOTCH4	6.31e-05	6	72	2	18239137
Pubmed	Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation.	NOTCH1 NOTCH4	6.31e-05	6	72	2	29228365
Pubmed	Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal.	NOTCH1 NOTCH4	6.31e-05	6	72	2	19503073
Pubmed	Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics.	USP10 NOTCH1	6.31e-05	6	72	2	35821235
Pubmed	Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.	NOTCH1 NOTCH4	6.31e-05	6	72	2	7835890
Pubmed	Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.	NOTCH1 NOTCH4	6.31e-05	6	72	2	18299578
Pubmed	Matrix metalloproteinase activity in pediatric acute lung injury.	MMP2 MMP11	6.31e-05	6	72	2	19159011
Pubmed	Notch4 reveals a novel mechanism regulating Notch signal transduction.	NOTCH1 NOTCH4	6.31e-05	6	72	2	24667410
Pubmed	The effect of epidermal growth factor on matrix metalloproteinases and tissue inhibitors of metalloproteinase gene expression in cultured human gingival fibroblasts.	MMP2 MMP11	6.31e-05	6	72	2	17181997
Pubmed	Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.	NOTCH1 NOTCH4	6.31e-05	6	72	2	15019995
Pubmed	Notch controls the magnitude of T helper cell responses by promoting cellular longevity.	NOTCH1 NOTCH4	6.31e-05	6	72	2	22615412
Pubmed	Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice.	NOTCH1 NOTCH4	6.31e-05	6	72	2	21991352
Pubmed	Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.	MUC5B NOTCH1 NOTCH4	8.57e-05	41	72	3	22675208
Pubmed	Human ligands of the Notch receptor.	NOTCH1 NOTCH4	8.82e-05	7	72	2	10079256
Pubmed	Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis.	NOTCH1 NOTCH4	8.82e-05	7	72	2	18952909
Pubmed	Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors.	USH2A RHO	8.82e-05	7	72	2	21212183
Pubmed	Expression of matrix metalloproteinases during murine chorioallantoic placenta maturation.	MMP2 MMP11	8.82e-05	7	72	2	10090151
Pubmed	Notch signaling functions in lymphatic valve formation.	NOTCH1 NOTCH4	8.82e-05	7	72	2	24917500
Pubmed	The distribution of Notch receptors and their ligands during articular cartilage development.	NOTCH1 NOTCH4	8.82e-05	7	72	2	12846471
Pubmed	Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.	NOTCH1 NOTCH4	8.82e-05	7	72	2	11518718
Pubmed	SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation.	NOTCH1 NOTCH4	8.82e-05	7	72	2	11585921
Pubmed	Slug is a direct Notch target required for initiation of cardiac cushion cellularization.	NOTCH1 NOTCH4	1.17e-04	8	72	2	18663143
Pubmed	Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients.	NOTCH1 NOTCH4	1.17e-04	8	72	2	22156581
Pubmed	Notch1 and Jagged1 expression by the developing pulmonary vasculature.	NOTCH1 NOTCH4	1.17e-04	8	72	2	12242716
Pubmed	Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.	NOTCH1 NOTCH4	1.17e-04	8	72	2	9858718
Pubmed	Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation.	MMP2 MMP11	1.17e-04	8	72	2	8674412
Pubmed	Notch signaling represses p63 expression in the developing surface ectoderm.	NOTCH1 NOTCH4	1.51e-04	9	72	2	23924630
GeneFamily	MAP kinase phosphatases	DUSP16 DUSP8	5.09e-04	11	56	2	895
Coexpression	GSE17721_CTRL_VS_PAM3CSK4_6H_BMDC_DN	GK DUSP16 WDFY3 MMP2 IPO4 GLIS1 NOTCH1	1.31e-06	200	72	7	M3742
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GK SLC2A9 GPX3 SLC5A12 GLIS1	8.52e-06	171	72	5	f5014e3c387fe3118944af392abe10d6b9b0abab
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	AZU1 GPX3 MUC5B ZFPM1 MMP2	8.76e-06	172	72	5	b66dbfff5e4f53ca8ece91ff9c5dc66a71f07c63
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RIN1 DUSP16 FOXO4 ZYG11B EPHA1	9.53e-06	175	72	5	6374ab186d7ccf7f6dfb858267edba8962789e15
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_activate-7\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HKDC1 FOXO4 ZFPM1 MAST2 TCTN2	9.79e-06	176	72	5	dde46f06f6fc3f7ba83be91a0ee6231790955e3e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GK SLC2A9 GPX3 SLC5A12 GLIS1	1.09e-05	180	72	5	1363b3254470f6ff98630d1df83a1bdbacc137e0
ToppCell	COVID-19-kidney-Mito-rich_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC2A9 GPX3 HKDC1 SLC5A12 GLIS1	1.25e-05	185	72	5	1bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 HKDC1 SLC5A12 GLIS1	1.31e-05	187	72	5	3ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TLR5 MUC5B MMP2 GLIS1	3.06e-05	110	72	4	b9c8014fd2820e5ea28a7e02fd24227b99e71eb3
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TLR5 MUC5B MMP2 GLIS1	3.06e-05	110	72	4	ee45592e936d32881c0f3429c21360670e5b3ce3
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-9\|TCGA-Liver / Sample_Type by Project: Shred V9	CYP7A1 TRO BPESC1 USH2A	9.72e-05	148	72	4	683b2b80ee389469d948aaf6a77632b24f56e989
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Pld5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	WNT9A HKDC1 ZFPM1 MAST3	1.28e-04	159	72	4	a082e770fa757c4a1d3ed13d53f83297e36faf05
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-Treg\|ICU-NoSEP / Disease, Lineage and Cell Type	DPH2 FMN1 TRO GPX3	1.28e-04	159	72	4	d065ec02a4f3672ba53d4fea66029f1ce68f367f
ToppCell	P07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GPX3 MMP2 SLC38A8 EPHA1	1.34e-04	161	72	4	b19f82dd98a3064581793711bb70373f18abecd9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	1.58e-04	168	72	4	fa0d251693935116adf633d02b7ec4a295100865
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPX3 LIX1L MMP2 EPHA1	1.62e-04	169	72	4	16c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nts_(peripeduncular_nucleus_&_posterior_intralaminar_thalamic_nucleus_(PP_&_PIL))-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	FER1L5 GLIS1 SLC38A8	1.67e-04	66	72	3	85e0027bf0d4ebdcb6cac358aedd1d74aa83c612
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nts_(peripeduncular_nucleus_&_posterior_intralaminar_thalamic_nucleus_(PP_&_PIL))\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	FER1L5 GLIS1 SLC38A8	1.67e-04	66	72	3	6cf03dd1db7607684cdcca7df08933f8cdc3adef
ToppCell	droplet-Liver-nan-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMN1 MPEG1 HKDC1 TCTN2	1.73e-04	172	72	4	1f335ccb92b22d0412954e8fc3af212f96410b67
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TMTC1 GPX3 ADGRF3 NOTCH4	1.73e-04	172	72	4	de9b11ab109d04937186c09772cec9105a935f95
ToppCell	droplet-Liver-nan-3m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMN1 MPEG1 HKDC1 TCTN2	1.73e-04	172	72	4	bb96c896d125e10b71e94e2bdad243899045af5c
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC2A9 CLCN6 DUSP16 ZFPM1	1.77e-04	173	72	4	c31076c725f4cd912c56903592a2d9356ae59f54
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC2A9 CLCN6 DUSP16 ZFPM1	1.77e-04	173	72	4	a4ed191cfdf6588b7f3672995bf0a4fe9e4b8df6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	1.77e-04	173	72	4	8888434641ea554a9b62c436e87920378eef29cd
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-9\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CLCN6 NETO1 TLR5 TCTN2	1.93e-04	177	72	4	ae55773c531099a9e94f44f01ba48b5e71dddc53
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC-arterial_capillary\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NETO1 GPX3 LAMA5 NOTCH4	1.98e-04	178	72	4	360d7a987f91d6d721487a921824057ec31a7332
ToppCell	COVID-19-kidney-PCT-S1/S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC2A9 GPX3 SLC5A12 GLIS1	1.98e-04	178	72	4	23a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCell	3'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMTC1 ADGRB2 LAMA5 NOTCH4	1.98e-04	178	72	4	c30d3390fc4a7856f50ba8ff6694c0333165ddde
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nnat_(Neuron.Slc17a6.Nnat)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SLC5A12 FER1L5 GLIS1	1.99e-04	70	72	3	df81f7c1d901eb34b82f564ee15c10a0f4dd153f
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nnat_(Neuron.Slc17a6.Nnat)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SLC5A12 FER1L5 GLIS1	1.99e-04	70	72	3	2895c9fa3b2c1fadbcfef7814ee4ce8cc5e76cfd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.02e-04	179	72	4	78fae47ec9bff4e0159a86a281e831d7f8ee925a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.06e-04	180	72	4	f8bdfd7bf7b3d52c659a29d8f5f80858e79da83e
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC2A9 HKDC1 SLC5A12 GLIS1	2.06e-04	180	72	4	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	COVID-19-kidney-tDL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC2A9 HKDC1 SLC5A12 GLIS1	2.06e-04	180	72	4	864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell	(01)_Cycling_Basal_(homeostasis)-(1)_24hpi\|(01)_Cycling_Basal_(homeostasis) / shred by cell type and Timepoint	MMP2 PSPH USH2A	2.08e-04	71	72	3	6aa56b0daaeb5e0ae30619f9c6945c8e42899b27
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RIN1 ADGRB2 HKDC1 MAST3	2.11e-04	181	72	4	58f76bb9ea1518c2b629a0256a3f6595a9278152
ToppCell	PBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPEG1 WDFY3 PSPH NOTCH4	2.11e-04	181	72	4	2b9b460239d67fd480cee60820cdb306109d3567
ToppCell	COVID-19-kidney-Stressed_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC2A9 HKDC1 SLC5A12 GLIS1	2.11e-04	181	72	4	6980ea624151da32b7f537f263e40fcb87a02e81
ToppCell	PBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MPEG1 WDFY3 PSPH NOTCH4	2.11e-04	181	72	4	2a1aa4a0ec7bc367857beaff543135e4345c835b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.15e-04	182	72	4	e1e58176f533092b6b974ca1ce8b02192a6e193d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.15e-04	182	72	4	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	CYP7A1 TRO WNT9A MMP2	2.15e-04	182	72	4	812dac35b9aa05be48258082e007f6c00e7b4dd8
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.15e-04	182	72	4	57bb5a2da976464ba7c4460106bd9f692008ebd9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.20e-04	183	72	4	facd6dbe0851b537d70a899ac7485714ab27d071
ToppCell	COVID-19-kidney-PCT-S1/S2\|kidney / Disease (COVID-19 only), tissue and cell type	SLC2A9 GPX3 SLC5A12 GLIS1	2.24e-04	184	72	4	dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.34e-04	186	72	4	8287146f0ba415ea04475588117d4668ae00f75c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.34e-04	186	72	4	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.38e-04	187	72	4	1b82920588f9e26ef1db244d452736d75fcfd342
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.38e-04	187	72	4	71eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.38e-04	187	72	4	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	COVID-19-kidney-tDL\|kidney / Disease (COVID-19 only), tissue and cell type	SLC2A9 GPX3 SLC5A12 GLIS1	2.38e-04	187	72	4	d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.38e-04	187	72	4	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	COVID-19-kidney-Mito-rich_PCT\|kidney / Disease (COVID-19 only), tissue and cell type	SLC2A9 GPX3 SLC5A12 GLIS1	2.38e-04	187	72	4	738ec2611b4be6a08eedad16b57fba84e1f11fef
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.38e-04	187	72	4	c1e4c0345f9bfa0538730bad5ff3fa5240168b25
ToppCell	COVID-19-kidney-Stressed_PCT\|kidney / Disease (COVID-19 only), tissue and cell type	SLC2A9 GPX3 SLC5A12 GLIS1	2.38e-04	187	72	4	acd305475f3609800af0d7bc68d83ef41228080b
ToppCell	droplet-Spleen-nan-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TARS3 DYNC2I1 DCLRE1A GLIS1	2.43e-04	188	72	4	1a3f95b4fd7611c634666761ddf21f1e58e56af8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.43e-04	188	72	4	f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Striatum / BrainAtlas - Mouse McCarroll V32	RIN1 NETO1 ADGRB2 MAST3	2.43e-04	188	72	4	e34ea7014c5a059a7db38f78bd903cf02616ddd3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.43e-04	188	72	4	0792432cd4c564dea1102241ea9884f7ced7658c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.48e-04	189	72	4	204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCell	10x5'v1-week_12-13-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	DUSP8 ADGRB2 MMP2 SLC38A8	2.48e-04	189	72	4	473b01c9162b12b90a617c600238436177a0d18d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 GPX3 SLC5A12 GLIS1	2.48e-04	189	72	4	13fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	SLC2A9 GPX3 SLC5A12 GLIS1	2.48e-04	189	72	4	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMTC1 GPX3 PPME1 NOTCH4	2.53e-04	190	72	4	d0297d678498e346e56cf95fe9e3db7d3ad3b837
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 HKDC1 SLC5A12 GLIS1	2.58e-04	191	72	4	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC2A9 HKDC1 SLC5A12 GLIS1	2.58e-04	191	72	4	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPX3 MMP2 MMP11 EPHA1	2.58e-04	191	72	4	d04e6292fef189b8d8ed0f4b0c310b2b250fd30e
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPX3 MMP2 MMP11 EPHA1	2.58e-04	191	72	4	de3e9b704621b26836c2ddc39fa3e840dfb4541b
ToppCell	PBMC-Severe-cDC_0\|Severe / Compartment, Disease Groups and Clusters	TMTC1 TBC1D30 TLR5 MPEG1	2.64e-04	192	72	4	4f4774b925058191673b4ba4b4d05b8b37f61795
ToppCell	Parenchymal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRO GPX3 PRAF2 GLIS1	2.69e-04	193	72	4	df4afb4848eb9d7d8d39e5c612919663cbbb2514
ToppCell	Parenchymal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRO GPX3 PRAF2 GLIS1	2.69e-04	193	72	4	ab36d684bde8fe77d11a5188425135328052c58b
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMA5 MMP2 MMP11 GLIS1	2.85e-04	196	72	4	1f47916c2663bd88c1e7c19c6a7688f4c7173ad2
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 MMP2 NOTCH1 NOTCH4	2.85e-04	196	72	4	a20a56d8997d6db2a10046c8801c619a379de83c
ToppCell	remission-Non-classical_Monocyte\|remission / disease stage, cell group and cell class	RIN1 TMTC1 MPEG1 NOTCH4	2.85e-04	196	72	4	049d995986c20ce066bd64fcc2d2f1c2f8899883
ToppCell	Striatum-Neuronal-Excitatory\|Striatum / BrainAtlas - Mouse McCarroll V32	RIN1 NETO1 ADGRB2 MAST3	2.85e-04	196	72	4	67400193ba469cf4d939e94f5ed94995e384bc07
ToppCell	medial-2-Hematologic-Classical_Monocyte\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GK FMN1 TLR5 MPEG1	2.91e-04	197	72	4	fbff79d6ece1605126ae0caa0c71253ea557779c
ToppCell	medial-Hematologic-Classical_Monocyte\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GK FMN1 TLR5 MPEG1	2.91e-04	197	72	4	3960eac4b6753e3294e13901f6ea13d894275c8d
ToppCell	medial-Hematologic-Classical_Monocyte-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GK FMN1 TLR5 MPEG1	2.91e-04	197	72	4	ae2b51d4e91126ee0a0f69c040297c2a78ce27dd
ToppCell	remission-Non-classical_Monocyte\|World / disease stage, cell group and cell class	RIN1 TMTC1 MPEG1 NOTCH4	2.96e-04	198	72	4	1c170655070acca00520b7cf9c510a04c0a90a8f
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-Treg\|ICU-NoSEP / Disease, condition lineage and cell class	DPH2 FMN1 DUSP16 GPX3	2.96e-04	198	72	4	1ed4dfe5565328cb0f7ef31e6b2f67dfbdf3e2ac
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GPX3 LAMA5 MMP2 MMP11	2.96e-04	198	72	4	d83707b69fb64721ac3cff90ba58cdd999d6b386
ToppCell	Parenchyma_Control_(B.)-Endothelial-TX-Endothelial-2\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	TMTC1 GPX3 LAMA5 NOTCH4	3.02e-04	199	72	4	523e01f6a0abd9820697572e042a381aae8932dc
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GPX3 LAMA5 MMP2 MMP11	3.02e-04	199	72	4	ec74ff85d6b61013b1f785b2fca343759feb7843
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-dn_T\|Leuk-UTI / Disease, condition lineage and cell class	THAP4 HKDC1 DCLRE1A PSPH	3.02e-04	199	72	4	aa4d8ce8994e5032a33d5cc68c482882147cdc3b
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-2-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TMTC1 GPX3 LAMA5 NOTCH4	3.02e-04	199	72	4	0d0d5cb821db16514192ad536849a8a04e22e637
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CYP7A1 MUC5B MMP2 MMP11	3.02e-04	199	72	4	45c3b853900d8c3d5965117d904e3714100138bc
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TMTC1 DUSP8 NOTCH1 NOTCH4	3.02e-04	199	72	4	fff88d2bba262583bb726900ae01e44954b72eb9
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-2\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TMTC1 GPX3 LAMA5 NOTCH4	3.02e-04	199	72	4	dfd60380a29f99e187050933ee5252ec11c68a32
ToppCell	Sigmoid-(4)_Monocyte\|Sigmoid / shred on region, Cell_type, and subtype	TMTC1 GK MPEG1 WDFY3	3.08e-04	200	72	4	7f3920a0434d5199c6c8f0b3064a305bb0d87b60
ToppCell	Sigmoid-Monocyte-Monocyte\|Sigmoid / Region, Cell class and subclass	TMTC1 GK MPEG1 WDFY3	3.08e-04	200	72	4	010ca36970cb8894bdbca08779c0ecf56be22fc9
ToppCell	Sigmoid-Monocyte\|Sigmoid / Region, Cell class and subclass	TMTC1 GK MPEG1 WDFY3	3.08e-04	200	72	4	c41bd6ec0f2262fce5cadb37a400d487e6662f49
ToppCell	Sigmoid-(4)_Monocyte-(40)_Monocyte\|Sigmoid / shred on region, Cell_type, and subtype	TMTC1 GK MPEG1 WDFY3	3.08e-04	200	72	4	576c0a1098e6a934448705de3673ef798fcf1b26
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CYP7A1 MUC5B MMP2 MMP11	3.08e-04	200	72	4	29054cf55e88e1ac81a562d8dd9af9b7c749321d
Disease	cholangiocarcinoma (is_marker_for)	WNT9A MUC5B MMP2 NOTCH1	1.75e-05	64	71	4	DOID:4947 (is_marker_for)
Disease	retinitis pigmentosa (is_implicated_in)	HKDC1 USH2A RHO	1.33e-04	41	71	3	DOID:10584 (is_implicated_in)
Disease	hemangiopericytoma (is_marker_for)	NOTCH1 NOTCH4	2.03e-04	9	71	2	DOID:264 (is_marker_for)
Disease	intracranial aneurysm (is_implicated_in)	KMT2D MMP2	3.71e-04	12	71	2	DOID:10941 (is_implicated_in)
Disease	transient cerebral ischemia (biomarker_via_orthology)	DUSP16 MMP2 NOTCH1 MAP3K5	5.68e-04	157	71	4	DOID:224 (biomarker_via_orthology)
Disease	myopia (is_implicated_in)	PARL MMP2	6.70e-04	16	71	2	DOID:11830 (is_implicated_in)
Disease	gastric ulcer (biomarker_via_orthology)	FOXO4 MMP2	1.16e-03	21	71	2	DOID:10808 (biomarker_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	ADGRF3 PSPH PRAF2 NOTCH1	1.27e-03	195	71	4	DOID:1574 (implicated_via_orthology)
Disease	Carcinoma, Pancreatic Ductal	NOTCH1 NOTCH4	1.52e-03	24	71	2	C0887833
Disease	retinitis pigmentosa (implicated_via_orthology)	USH2A RHO	1.93e-03	27	71	2	DOID:10584 (implicated_via_orthology)
Disease	glucose metabolism disease (implicated_via_orthology)	TLR5 HKDC1	2.07e-03	28	71	2	DOID:4194 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
AAGLELCSGSGPFTF	ADGRB2	136	O60241
FTVRDCKSFPGGAGP	EPHA1	101	P21709
AADTCFLGAPFLSPG	ADGRF3	821	Q8IZF5
FAILGFCLFGSPDNG	CATSPER3	191	Q86XQ3
ILTGGFATFSSCFPG	DUSP8	121	Q13202
FHSGCFLFPFFLPGV	GJA10	496	Q969M2
PFGLVILGFPCNQFG	GPX3	91	P22352
CPLGALAPQLSGSFF	DPH2	341	Q9BQC3
GGNSEGAPCVFPFTF	MMP2	341	P08253
TPCFCRAFGQFFSPG	MUC5B	4941	Q9HC84
GPFGFSPIIGRFCGQ	NETO1	106	Q8TDF5
PPGLFFGLGSSSSQC	FMN1	956	Q68DA7
GPTGCNLEGFFATLG	RHO	106	P08100
VPFGGFFSCTVGNPL	MPEG1	526	Q2M385
RFAEPIGGFQCVFPG	PPME1	371	Q9Y570
SVPLFGFFGNGEIGC	FBXO22	351	Q8NEZ5
GINSFTCLCPPGFTG	NOTCH1	1001	P46531
GGDPSVFCSLPLGFF	GK3P	521	Q14409
FPLGNGDGAFVSCLP	HOXD1	41	Q9GZZ0
DFSPFGEPIFLAGCS	DYNC2I1	916	Q8WVS4
FSPAEGPLSAGEGCF	FOXO4	346	P98177
GAQIFFLPTLGGGEC	OR2T8	96	A6NH00
QTGLFPGAPKGATCF	ZFPM1	566	Q8IX07
TLPGGSCFGSFQFCP	LIX1L	141	Q8IVB5
PTVGLFSFGDPCGDR	TUBGCP6	191	Q96RT7
CAPGFFGNPLVLGSS	LAMA5	1951	O15230
FFLAPCVEPGRAGTF	NLRX1	476	Q86UT6
GPSPGFFSKTLFNCL	G2E3	461	Q7L622
SGLFVPSLLCGAAFG	CLCN6	486	P51797
SRGPCLDFAPLSGSF	PCIF1	536	Q9H4Z3
LAGGFAEFSRCFPGL	DUSP16	121	Q9BY84
DEFFFGSGGISSCPP	DESI1	46	Q6ICB0
ESGDPSIFCSLPLGF	GK	526	P32189
FFIPFLPSGFGGSGL	BPESC1	31	Q9GZL8
PPFTVFSGCPGLFSG	DCTN5	141	Q9BTE1
FSGCPGLFSGELPEC	DCTN5	146	Q9BTE1
GCVPFFGDTPEELFG	MAST2	721	Q6P0Q8
GCVPFFGDTPEELFG	MAST3	576	O60307
DIGAVFGLGFPPCLG	HADHA	701	P40939
FGLGFPPCLGGPFRF	HADHA	706	P40939
AIIASFCSGPGGIPF	SLC2A9	421	Q9NRM0
FCSGPGGIPFILTGE	SLC2A9	426	Q9NRM0
PFGSGATICPGRLFA	CYP7A1	436	P22680
ACTGGDFVLFPPALA	DCLRE1A	401	Q6PJP8
VSSGPEDCGFFPNGA	GLIS1	591	Q8NBF1
SFSLGPCGRGPDFFT	AZU1	216	P20160
AGGDSFAPFFAGFLP	IPO4	846	Q8TEX9
DCTVSFPGFEAFGLG	LINC00575	51	Q6W349
PLFFTVGFTGCAFGS	PARL	101	Q9H300
FAPSGFCTIPEGGIC	MAP3K5	16	Q99683
LEGFPRLVGPDFFGC	MMP11	466	P24347
PLVSGCPGFSLGCFF	RUSF1	251	Q96GQ5
DLSPGSCFFLPRGAF	TARS3	416	A2RTX5
DPFPFEHFRGGGGVC	USH2A	591	O75445
QGTGAALCFFNPLFP	RIN1	216	Q13671
SGFLPCFGPSFLTLH	FER1L5	426	A0AVI2
KGASLPLGFTFSFPC	HKDC1	591	Q2TB90
AASGGLGPAFPGTFC	SLAIN1	91	Q8ND83
GGISSFFIFIFPGLC	SLC38A8	376	A6NNN8
DLPGAFFCLCPSGFT	NOTCH4	606	Q99466
FNPFFPLLGCFTTPG	ZYG11B	651	Q9C0D3
SLEGFGCLFLPSLAP	WDFY3	1051	Q8IZQ1
CVGGSFPSTVSPFFL	TMTC1	191	Q8IUR5
ACPPADAFIGFGGNV	PSPH	186	P78330
SACFSGAPITNPGFG	TRO	1086	Q12816
VAGGACTFLFSIAGP	PRAF2	116	O60831
AGGALFFPGLFALCT	TLCD3A	6	Q8TBR7
VGCLGPFSGFLAPEL	TBC1D30	571	Q9Y2I9
PSFCLAGRFSPGTAG	WNT9A	296	O14904
PGADFGQSCFPAEAG	USP10	246	Q14694
GPVFGIPSCSFDGRI	TLR5	16	O60602
PGLPGLFVACAFSGT	SLC5A12	331	Q1EHB4
PGFPFLGNDFFGTLG	VWA8	906	A3KMH1
SCFTGVFGGDVNPPF	TCTN2	201	Q96GX1
FTPPGSGACKFIGSL	THAP4	221	Q8WY91
ANFSLFAPFGSGCPV	KMT2D	4571	O14686