Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	VWC	KCP CHRD	4.00e-03	28	63	2	PF00093
Domain	C1Q	CBLN3 C1QTNF7	5.20e-03	32	63	2	SM00110
Domain	C1q	CBLN3 C1QTNF7	5.20e-03	32	63	2	PF00386
Domain	C1q_dom	CBLN3 C1QTNF7	5.86e-03	34	63	2	IPR001073
Domain	C1Q	CBLN3 C1QTNF7	5.86e-03	34	63	2	PS50871
Domain	VWFC_1	KCP CHRD	6.55e-03	36	63	2	PS01208
Domain	VWC	KCP CHRD	7.28e-03	38	63	2	SM00214
Domain	VWFC_2	KCP CHRD	7.28e-03	38	63	2	PS50184
Pubmed	Crucial roles of MZF-1 in the transcriptional regulation of apomorphine-induced modulation of FGF-2 expression in astrocytic cultures.	MZF1 FGF2	4.11e-06	2	71	2	19196427
Pubmed	Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death.	TNK2 TNFRSF10B	1.23e-05	3	71	2	24085293
Pubmed	Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation.	CASP14 BCL11A SMPD3	1.82e-05	25	71	3	19092943
Pubmed	FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles.	FGF2 TNK2	4.09e-05	5	71	2	18838382
Pubmed	Craniofacial consequences of connective tissue disorders in mice.	GRIP1 SMPD3	6.13e-05	6	71	2	6391574
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	FAM193B MID1IP1 RNF31 FGF2 TNK2 ERMP1 TSEN2 LIN28A SMAD6 NKX1-2	1.74e-04	1215	71	10	15146197
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	ASPHD1 METRN MZF1 WDR6 FGF2 TNK2 ERMP1 KLHDC4 SMAD6	2.28e-04	1021	71	9	26760575
Pubmed	LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.	RNF31 TNFRSF10B	2.68e-04	12	71	2	30254289
Pubmed	Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors.	ADGRA2 NKX1-2	2.68e-04	12	71	2	27793834
Pubmed	Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells.	CHRD SMAD6	3.68e-04	14	71	2	26952187
Pubmed	Laminar organization of the early developing anterior hypothalamus.	PDZRN4 NKX1-2	4.84e-04	16	71	2	16860307
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	ASPHD1 MID1IP1 METRN GDF1 SLC25A28 GOLGA8A SMAD6	5.52e-04	697	71	7	28298427
Pubmed	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	DMGDH HIC1 FGF2 TNFRSF10B GDF1	5.90e-04	331	71	5	20634891
Pubmed	OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways.	FLNC RNF31	6.87e-04	19	71	2	35941131
Pubmed	Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.	TPO DMGDH ACOT8 NTHL1 POLRMT SLC25A28	8.47e-04	542	71	6	14651853
Pubmed	Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase.	FLNC PBXIP1	1.10e-03	24	71	2	19616115
Pubmed	Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.	CASP14 KRT84 KPRP	1.39e-03	107	71	3	32989256
Pubmed	Conditionals by inversion provide a universal method for the generation of conditional alleles.	CHRD ADGRA2	1.40e-03	27	71	2	23918385
Pubmed	Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development.	CASP14 TNFRSF10B	1.50e-03	28	71	2	38131461
Pubmed	A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation.	LIN28A NKX1-2	1.72e-03	30	71	2	32597756
Pubmed	Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development.	ARHGEF28 SMAD6	1.72e-03	30	71	2	38310234
Pubmed	c-Jun is required for the specification of joint cell fates.	MZF1 CHRD	1.84e-03	31	71	2	23475960
Pubmed	Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.	GOLGA8A ADAMTSL2	1.84e-03	31	71	2	25762570
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-23\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RNF224 ALPK3 KNDC1 SLC5A9 GRM6	3.69e-06	144	72	5	e9d62f202f0fa8747961036ef0eafed91fe8a42f
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	HIC1 COL16A1 CHRD C1QTNF7 ADGRA2	1.03e-05	178	72	5	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	GRIP1 ASPHD1 SLC5A9 SMPD3 PDZRN4	1.31e-05	187	72	5	8e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCell	droplet-Lung-nan-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIC1 COL16A1 C1QTNF7 GDF1 ADAMTSL2	1.31e-05	187	72	5	51f1c6bac3abae1d20aa8ac46642bcdbc02cb0a2
ToppCell	facs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL16A1 KCP CHRD C1QTNF7 ADAMTSL2	1.49e-05	192	72	5	671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCell	facs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL16A1 KCP CHRD C1QTNF7 ADAMTSL2	1.49e-05	192	72	5	840a34c1b82d218be999ab5e1bcafd6370d7a4b1
Disease	colorectal cancer, colorectal adenoma	MZF1 METRNL SLC25A28 SMAD6	4.03e-04	152	67	4	EFO_0005406, MONDO_0005575
Disease	Agouti-related protein measurement	SMPD3 ENKD1	1.72e-03	27	67	2	EFO_0008016
Disease	thoracic aortic aneurysm	COL16A1 SMAD6	2.12e-03	30	67	2	EFO_0004282
Disease	left ventricular systolic function measurement	FLNC ALPK3	4.52e-03	44	67	2	EFO_0008206

Protein segments in the cluster

Peptide	Gene	Start	Entry
QGCGDRGDPPGDLRS	ACOT8	11	O14734
GPCIGPGAGEILERG	ENKD1	56	Q9H0I2
GGVPGPARRRVVCSG	ADGRA2	56	Q96PE1
PGRDGRPGEICVIGP	COL16A1	416	Q07092
GGERCRGPQSSGPVE	ALPK3	1016	Q96L96
QEPLVDGCSGGGRTR	ERMP1	36	Q7Z2K6
RGCPGDGPEAGRPAD	TNK2	946	Q07912
EVPARGGCGPTPRAG	PDZRN4	126	Q6ZMN7
VGAEGPEGPGCRVLF	MAP4K2	666	Q12851
REGRGCSDVDPGIQG	ARHGEF28	1331	Q8N1W1
RGGLVCGPEPLVAGS	KRT84	491	Q9NSB2
VGGSGGCLEERTPPV	MID1IP1	56	Q9NPA3
LLAEGPGPAGGRCVR	METRN	106	Q9UJH8
ERELGACVAPGAGPR	FAM149A	151	A5PLN7
CEERGGDAAVSPGGP	HIC1	356	Q14526
RVAGRGPAEAGCLPG	FAM86JP	21	Q05BU3
RAGGVRGGPVGCSEA	ASPHD1	111	Q5U4P2
EPVLGGGPGGACRAR	GDF1	256	P27539
GAASEAPGGRGCDRP	LBHD1	221	Q9BQE6
RIDDGTVNGRGCSPG	BCL11A	596	Q9H165
QGGECEIRRAGPGSE	KIFC1	481	Q9BW19
IPGETRGPCFLAGDG	TPO	381	P07202
EGCDPTRVRAFGPGL	FLNC	1346	Q14315
AGGGEAGACRPPVRQ	SLC25A28	41	Q96A46
VCEQAGGGACEGPPR	ADAMTSL2	406	Q86TH1
VPDGDGRPGRVQCFG	METRNL	131	Q641Q3
EQSPCPSRGRVEGGG	ASIC4	501	Q96FT7
DACIVRIGGEEGGRP	SMPD3	241	Q9NY59
PCRAAGVSPGTGGRE	INSM2	76	Q96T92
SEELPPGDRGCRNGG	NDFIP2	46	Q9NV92
GDGDEVGVRCPGGVP	GRM6	121	O15303
CAEAGEGSRGSRPGP	FAM193B	766	Q96PV7
VLPEGPEAGGGRLCF	FNDC10	41	F2Z333
GPGPVAGPRDVGTCR	CASC2	11	Q8IU53
GSPGRPRSVCGREGE	DMGDH	21	Q9UI17
GGDVEDVTPRPGGCQ	FGF2	6	P09038
DVTPRPGGCQISGRG	FGF2	11	P09038
RKEEPEGGSRPACGG	KLHDC4	361	Q8TBB5
SGAGCGPGDVFPERR	KPRP	541	Q5T749
VPCAGRSTDRGPGVP	KNDC1	376	Q76NI1
LVVCEPGRAAAGGPG	CBLN3	46	Q6UW01
VITCVRPGGPADREG	GRIP1	181	Q9Y3R0
ACRGEQRDPGETVGG	CASP14	131	P31944
PGKEGTAGGVCGPRR	POLRMT	26	O00411
DRGEQGDPGLPGVCR	C1QTNF7	126	Q9BXJ2
GRVGRITGLDPAGPC	PNLIPRP2	186	P54317
VGGSGRRCSDPAGQP	GOLGA8A	36	A7E2F4
GGVGDPREPLGCLQE	TSEN2	181	Q8NCE0
SRAEPAPRAREGGGC	SMAD6	41	O43541
EGGGCGRSEVRPVAP	SMAD6	51	O43541
ESRGGVPGGCVLVPR	SMAD6	196	O43541
PADAVPTGRRGEPCG	SAMD5	86	Q5TGI4
ASGEPCEDGGGGPVR	NKX1-2	126	Q9UD57
GGFVTCGRRPCEPPG	KCP	811	Q6ZWJ8
RSLGPGAGPRGCREE	NTHL1	21	P78549
PAAGRCGGDLVQERP	PIK3R6	261	Q5UE93
GLGGGGPPEERTDCI	RNF224	11	P0DH78
ISERPAGECPAGGGA	SLC5A9	586	Q2M3M2
VRPRAPTGEPGGVGC	SDHAF1	76	A6NFY7
EPEGRRARGPSCGEP	SPAG4	46	Q9NPE6
EPLPVRGAAGCTFGG	CHRD	41	Q9H2X0
EPPAGARAVPGGGCR	RNF31	956	Q96EP0
GVCARPPEGGDGARD	WDR90	1051	Q96KV7
VRGPDGVCLSGGRGP	PBXIP1	346	Q96AQ6
LGRVCEQEPGGPAGS	ZSCAN25	306	Q6NSZ9
PAGRVAGPGEVSDGC	TMDD1	96	P0DPE3
GICSGGGGDPERVDR	TNFRSF10B	246	O14763
LACEVGPGRGPQRGS	PYCARD-AS1	161	I3L0S3
PPGDFLVCGDRRGSV	WDR6	501	Q9NNW5
RGSCGVPDSAQRGPG	ZC3H12D	61	A2A288
LGGVCGREGAGAEVP	ZNF252P-AS1	16	Q0IIN9
GREGAGAEVPPAACG	ZNF252P-AS1	21	Q0IIN9
PRGSGLELVRVCGGG	SMIM45	61	A0A590UK83
GPGGVFCIGSERRPK	LIN28A	111	Q9H9Z2
GSGGCSRGPGEVVFR	ART5	146	Q96L15
PSTGGGVVRGGRCDV	MZF1	346	P28698