Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontaste receptor activity

TAS2R3 TAS2R31 PKD1L3

5.95e-0533463GO:0008527
GeneOntologyMolecularFunctionpalmitoyltransferase activity

ZDHHC2 ZDHHC13 CPT1C

8.42e-0537463GO:0016409
GeneOntologyMolecularFunctionG protein-coupled receptor activity

GPR78 OR1M1 OR2J1 TAS2R3 OR2J2 TAS2R31 OR4F21 GPR45

8.35e-04884468GO:0004930
GeneOntologyMolecularFunctionserine-type endopeptidase activity

TMPRSS11F PRSS47P MMP13 HPN

9.48e-04190464GO:0004252
GeneOntologyMolecularFunctionserine-type peptidase activity

TMPRSS11F PRSS47P MMP13 HPN

1.30e-03207464GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

TMPRSS11F PRSS47P MMP13 HPN

1.42e-03212464GO:0017171
GeneOntologyMolecularFunctionprotein-cysteine S-palmitoyltransferase activity

ZDHHC2 ZDHHC13

1.63e-0326462GO:0019706
GeneOntologyMolecularFunctionprotein-cysteine S-acyltransferase activity

ZDHHC2 ZDHHC13

1.63e-0326462GO:0019707
GeneOntologyMolecularFunctionbitter taste receptor activity

TAS2R3 TAS2R31

1.76e-0327462GO:0033038
GeneOntologyMolecularFunctionS-acyltransferase activity

ZDHHC2 ZDHHC13

2.17e-0330462GO:0016417
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

GPR78 OR1M1 OR2J1 TAS2R3 OR2J2 TAS2R31 OR4F21 PKD1L3 GPR45

3.30e-031353469GO:0004888
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

COX15 CALHM5 PKD1L3 SLC12A9 ZDHHC13 KCNJ14

3.99e-03664466GO:0008324
GeneOntologyMolecularFunctiontransmembrane transporter activity

COX15 CALHM5 PKD1L3 CYB561A3 SLC14A1 SLC12A9 ZDHHC13 KCNJ14

5.09e-031180468GO:0022857
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR1M1 OR2J1 TAS2R3 OR2J2 TAS2R31 OR4F21 STRC PKD1L3 HPN

5.58e-06582479GO:0050906
GeneOntologyBiologicalProcessdetection of stimulus

OR1M1 OR2J1 TAS2R3 OR2J2 TAS2R31 OR4F21 STRC PKD1L3 HPN

3.10e-05722479GO:0051606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR1M1 OR2J1 TAS2R3 OR2J2 TAS2R31 OR4F21 PKD1L3

1.06e-04485477GO:0050907
GeneOntologyBiologicalProcesssensory perception

OR1M1 OR2J1 TAS2R3 OR2J2 TAS2R31 OR4F21 STRC PKD1L3 TMTC4 HPN

1.23e-0410724710GO:0007600
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR1M1 OR2J1 TAS2R3 OR2J2 TAS2R31 OR4F21 PKD1L3

1.71e-04524477GO:0009593
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of taste

TAS2R3 TAS2R31 PKD1L3

2.02e-0450473GO:0050912
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR1M1 OR2J1 TAS2R3 OR2J2 TAS2R31 OR4F21 PKD1L3

2.23e-04547477GO:0007606
DomainGPCR_Rhodpsn

GPR78 OR1M1 OR2J1 TAS2R3 OR2J2 OR4F21 GPR45

1.24e-03692457IPR000276
Domainzf-DHHC

ZDHHC2 ZDHHC13

1.39e-0323452PF01529
DomainDHHC

ZDHHC2 ZDHHC13

1.64e-0325452PS50216
DomainZnf_DHHC_palmitoyltrfase

ZDHHC2 ZDHHC13

1.64e-0325452IPR001594
DomainTAS2R

TAS2R3 TAS2R31

1.78e-0326452PF05296
DomainT2R

TAS2R3 TAS2R31

1.78e-0326452IPR007960
DomainPeptidase_S1_PA

COX15 TMPRSS11F HPN

3.23e-03123453IPR009003
Domain7tm_1

GPR78 OR1M1 OR2J1 OR2J2 OR4F21 GPR45

5.42e-03677456PF00001
DomainG_PROTEIN_RECEP_F1_1

GPR78 OR1M1 OR2J1 OR2J2 OR4F21 GPR45

5.74e-03685456PS00237
DomainG_PROTEIN_RECEP_F1_2

GPR78 OR1M1 OR2J1 OR2J2 OR4F21 GPR45

5.98e-03691456PS50262
PathwayREACTOME_SENSORY_PERCEPTION

OR1M1 OR2J1 TAS2R3 OR2J2 TAS2R31 OR4F21 STRC

1.14e-04636267M41834
PathwayREACTOME_SENSORY_PERCEPTION

OR2J1 TAS2R3 OR2J2 TAS2R31

3.79e-04190264MM15687
Pubmed

Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation.

KISS1 GPR45

1.07e-05447222262891
Pubmed

Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex.

OR2J1 OR2J2

1.38e-041347214506126
Pubmed

Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.

ZDHHC2 ZDHHC13

3.34e-042047216647879
Pubmed

Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs.

RGMA ZDHHC13 COL27A1

3.41e-0410047326073538
Pubmed

A novel family of mammalian taste receptors.

TAS2R3 TAS2R31

3.69e-042147210761934
Pubmed

Evolutionary relationships of the Tas2r receptor gene families in mouse and human.

TAS2R3 TAS2R31

4.06e-042247212734386
Pubmed

The molecular receptive ranges of human TAS2R bitter taste receptors.

TAS2R3 TAS2R31

4.44e-042347220022913
Pubmed

Receptors for bitter and sweet taste.

TAS2R3 TAS2R31

5.26e-042547212139982
Pubmed

Molecular mechanisms of bitter and sweet taste transduction.

TAS2R3 TAS2R31

5.69e-042647211696554
Pubmed

Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

TAS2R3 TAS2R31

6.14e-042747212581520
Pubmed

Adaptive diversification of bitter taste receptor genes in Mammalian evolution.

TAS2R3 TAS2R31

7.59e-043047212679530
Pubmed

Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis.

TMEM128 TMEM147

8.11e-043147223142642
Pubmed

Evolution of bitter taste receptors in humans and apes.

TAS2R3 TAS2R31

9.75e-043447215496549
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR1M1 OR2J1 OR2J2 OR4F21

1.15e-0334047411875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR1M1 OR2J1 OR2J2 OR4F21

1.15e-0334047411802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR1M1 OR2J1 OR2J2 OR4F21

1.19e-0334347432295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR1M1 OR2J1 OR2J2 OR4F21

1.23e-0334647414611657
Pubmed

The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity.

HPN TMEM147

1.28e-033947223864651
GeneFamilyProteases, serine

TMPRSS11F PRSS47P HPN

2.04e-0463333738
GeneFamilyZinc fingers DHHC-type|Ankyrin repeat domain containing

ZDHHC2 ZDHHC13

8.70e-042433276
GeneFamilyTaste 2 receptors

TAS2R3 TAS2R31

2.29e-03393321162
Diseaseovarian carcinoma (is_marker_for)

MMP13 KISS1

5.98e-0428382DOID:4001 (is_marker_for)
Diseaseinvasive ductal carcinoma (is_marker_for)

MMP13 KISS1

1.22e-0340382DOID:3008 (is_marker_for)
DiseaseS-6-hydroxywarfarin to S-warfarin ratio measurement

RNF150 BIRC6

5.77e-0388382EFO_0803332
Diseaseserum albumin measurement

PKD1L3 CPT1C HPN TMEM147

6.90e-03592384EFO_0004535
DiseaseWeight Gain

ZDHHC2 VPS13D

7.67e-03102382C0043094
Diseaseurinary bladder cancer (is_marker_for)

MMP13 KISS1

8.41e-03107382DOID:11054 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
DSFCSGQTLWELLSH

ASPSCR1

106

Q9BZE9
LWTALLFLLCHSGST

BIRC6

3711

Q9NR09
LLLGSTCGHWDIFSS

SMPD1

161

P17405
LLSQGATLSGWYHLC

FCN3

96

O75636
TSALHSSFTFWIPLC

OR2J1

156

Q9GZK6
CLSFLAVAWTLGVSH

OR4F21

141

O95013
AELCGSLLTWLQTFH

HOOK2

6

Q96ED9
LAAFLFLSWTHCRAL

MMP13

6

P45452
AHSFALSLCGTSFGW

HERC6

191

Q8IVU3
SWQLLLFLCATHFGE

KISS1

6

Q15726
WCLLFSSELHGHSFS

MEAK7

266

Q6P9B6
ISALHSSFTFWVPLC

OR2J2

156

O76002
WLGYSSAFASCSLRL

GPR78

146

Q96P69
FSLCWLPHSVYSLLS

GPR45

276

Q9Y5Y3
SLLSGDWVLTAAHCF

HPN

191

P05981
LLFSCSFLASWLLFG

KCNJ14

91

Q9UNX9
ASCLWGALIFTLHVA

CPT1C

111

Q8TCG5
ILGWCLICSASFFSL

CALHM5

181

Q8N5C1
GGFLFSWILVSFACH

COL27A1

21

Q8IZC6
RSLLWHFSNLGKSFC

ASNSD1

141

Q9NWL6
QGFFLDCLAWSTSAH

KHNYN

96

O15037
LHSWLGITTVFLFAC

CYB561A3

116

Q8NBI2
ECLGSLSFITHLDWS

EML5

446

Q05BV3
HLGSALVLYCASLWT

COX15

226

Q7KZN9
GALWAFSCFISLTHI

OR1M1

146

Q8NGA1
CLSFLAVAWTLGVSH

OR4F3;

141

Q6IEY1
SLALSTWLLSFCFVH

RNF150

11

Q9ULK6
TGHFSNWLATSLSIF

TAS2R31

91

P59538
FTNHLSIWLATCLGV

TAS2R3

91

Q9NYW6
LFLTLITHCAGSWAQ

IGLV1-36

6

A0A0B4J1U3
SDFWNFSSLDLLHLG

SLITRK3

426

O94933
GTSLWDLLSSCHFTE

EPPK1

1141

P58107
VCWLLLGFTSLASAF

PKD1L3

1156

Q7Z443
ASLLYWGSHLCGAVL

PRSS47P

96

A8MTI9
GSFFWLLLLLTAACS

ST6GALNAC2

6

Q9UJ37
SALGFWPTLAFLLCS

RGMA

26

Q96B86
SWEFSQAALFLGTLH

STRC

1611

Q7RTU9
HSSTFWVLLSIFLGA

TMTC4

201

Q5T4D3
FHTSSWFLCGSALLL

TMEM128

76

Q5BJH2
SLISNTWLLTAAHCF

TMPRSS11F

236

Q6ZWK6
LATFHFSWSTFLLLN

ZDHHC13

526

Q8IUH4
FSLFSWHTCLLGVAS

SLC12A9

451

Q9BXP2
ASHLAWFGDSLTSLS

TMEM214

581

Q6NUQ4
WQTHLLALGCALFTA

SLC14A1

306

Q13336
SFAHSIVSGIWALLC

TLCD1

51

Q96CP7
FSVSLSSLFGYHCWL

ZDHHC2

221

Q9UIJ5
FVHLCSLGSWAALLA

TMEM147

186

Q9BVK8
ALRNHTGCTLWFATL

VPS13D

2891

Q5THJ4