Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninsulin receptor activity

INSR INSRR

2.31e-053562GO:0005009
GeneOntologyMolecularFunctionserine-type endopeptidase activity

HGFAC RHBDF1 LPA PLG OVCH1

1.91e-04190565GO:0004252
GeneOntologyMolecularFunctionserine-type peptidase activity

HGFAC RHBDF1 LPA PLG OVCH1

2.84e-04207565GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

HGFAC RHBDF1 LPA PLG OVCH1

3.17e-04212565GO:0017171
GeneOntologyMolecularFunctionphosphatidate phosphatase activity

LPIN3 LPIN2

6.88e-0414562GO:0008195
GeneOntologyMolecularFunctioninsulin receptor substrate binding

INSR INSRR

7.92e-0415562GO:0043560
GeneOntologyMolecularFunctionprotein antigen binding

LPA PLG

9.04e-0416562GO:1990405
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP10 LRP1B

9.04e-0416562GO:0005041
GeneOntologyMolecularFunctionlipid phosphatase activity

LPIN3 LPIN2

1.28e-0319562GO:0042577
GeneOntologyMolecularFunctionapolipoprotein binding

LPA PLG

1.42e-0320562GO:0034185
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP10 LRP1B

1.57e-0321562GO:0030228
GeneOntologyMolecularFunctionprotein-hormone receptor activity

INSR INSRR

1.72e-0322562GO:0016500
GeneOntologyMolecularFunctioncargo receptor activity

LRP10 INSR LRP1B

1.75e-0385563GO:0038024
GeneOntologyMolecularFunctionextracellular matrix structural constituent

TINAGL1 LAMC1 MUC2 MUC6

1.91e-03188564GO:0005201
GeneOntologyCellularComponentinsulin receptor complex

INSR INSRR

4.37e-054572GO:0005899
GeneOntologyCellularComponentextracellular matrix

TINAGL1 CRISPLD2 LPA LAMC1 PLG MUC2 MUC6 OTOG

3.83e-04656578GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

TINAGL1 CRISPLD2 LPA LAMC1 PLG MUC2 MUC6 OTOG

3.91e-04658578GO:0030312
MousePhenoabnormal mammary gland connective tissue morphology

LPA PLG

7.98e-062402MP:0009507
MousePhenoesophageal ulcer

LPA PLG

7.98e-062402MP:0004547
MousePhenoduodenal ulcer

LPA PLG

7.98e-062402MP:0003273
MousePhenoperianal ulcer

LPA PLG

7.98e-062402MP:0005035
MousePhenoectropion

LPA PLG

7.98e-062402MP:0006164
MousePhenoabsent cornea epithelium

LPA PLG

2.39e-053402MP:0020856
MousePhenoincreased circulating fibrinogen level

LPA PLG

4.77e-054402MP:0012331
MousePhenoproctitis

LPA PLG

4.77e-054402MP:0003305
MousePhenogastric ulcer

LPA PLG

1.19e-046402MP:0003282
MousePhenoincreased acute phase protein level

LPA PLG

1.66e-047402MP:0014499
MousePhenoabnormal conjunctival epithelium morphology

LPA PLG

1.66e-047402MP:0004481
MousePhenovenoocclusion

LPA PLG

1.66e-047402MP:0006137
MousePhenopeptic ulcer

LPA PLG

1.66e-047402MP:0003301
MousePhenodecreased keratinocyte migration

LPA PLG

2.21e-048402MP:0012194
MousePhenoabnormal circulating fibrinogen level

LPA PLG

2.21e-048402MP:0010213
MousePhenodecreased susceptibility to induced morbidity/mortality

LPA INSR NOX4 PLG

2.31e-04106404MP:0009764
MousePhenoabnormal Cajal-Retzius cell morphology

FKRP LAMC1

3.54e-0410402MP:0008030
MousePhenodecreased susceptibility to induced choroidal neovascularization

LPA PLG

3.54e-0410402MP:0003434
MousePhenoabnormal kidney thrombosis

LPA PLG

3.54e-0410402MP:0011507
MousePhenoabnormal keratinocyte migration

LPA PLG

4.32e-0411402MP:0012192
MousePhenoabnormal meninges morphology

FKRP LAMC1

5.17e-0412402MP:0005623
MousePhenoenlarged lymph nodes

PHF20L1 LPA CNGB3 LPIN2 NOX4 ALOXE3 PLG

5.22e-04507407MP:0000702
MousePhenoabnormal anus morphology

LPA PLG

6.10e-0413402MP:0005034
MousePhenoabnormal conjunctiva morphology

LPA PLG

6.10e-0413402MP:0001310
MousePhenodecreased cell migration

MYO9A LPA PLG

8.38e-0465403MP:0011805
MousePhenoabnormal lymph node size

PHF20L1 LPA CNGB3 LPIN2 NOX4 ALOXE3 PLG

9.50e-04561407MP:0000701
MousePhenoincreased hepatocyte proliferation

LPA PLG

1.06e-0317402MP:0003893
MousePhenolactation failure

LPA PLG

1.06e-0317402MP:0010249
MousePhenodecreased neuron apoptosis

LPA NOX4 PLG

1.18e-0373403MP:0003204
MousePhenochoroidal neovascularization

LPA PLG

1.32e-0319402MP:0005546
MousePhenoabnormal cortical marginal zone morphology

FKRP LAMC1

1.32e-0319402MP:0000792
MousePhenoabnormal Muller cell morphology

FKRP CRB1

1.47e-0320402MP:0005547
MousePhenoincreased urine microalbumin level

SCAMP5 MAS1

1.47e-0320402MP:0002959
DomainVWD

SUSD2 MUC2 MUC6 OTOG

1.19e-0716554SM00216
DomainVWF_type-D

SUSD2 MUC2 MUC6 OTOG

1.19e-0716554IPR001846
DomainVWFD

SUSD2 MUC2 MUC6 OTOG

1.19e-0716554PS51233
DomainVWD

SUSD2 MUC2 MUC6 OTOG

1.19e-0716554PF00094
DomainSCAMP

SCAMP5 SCAMP1 SCAMP2

2.41e-075553IPR007273
DomainSCAMP

SCAMP5 SCAMP1 SCAMP2

2.41e-075553PF04144
DomainTIL

MUC2 MUC6 OTOG

5.22e-0612553PF01826
DomainC8

MUC2 MUC6 OTOG

5.22e-0612553PF08742
DomainUnchr_dom_Cys-rich

MUC2 MUC6 OTOG

6.77e-0613553IPR014853
DomainC8

MUC2 MUC6 OTOG

6.77e-0613553SM00832
DomainTIL_dom

MUC2 MUC6 OTOG

8.60e-0614553IPR002919
DomainKringle

HGFAC LPA PLG

1.60e-0517553IPR000001
DomainKringle_CS

HGFAC LPA PLG

1.60e-0517553IPR018056
DomainKRINGLE_2

HGFAC LPA PLG

1.60e-0517553PS50070
DomainKringle

HGFAC LPA PLG

1.60e-0517553PF00051
DomainKRINGLE_1

HGFAC LPA PLG

1.60e-0517553PS00021
DomainKR

HGFAC LPA PLG

1.60e-0517553SM00130
DomainVWC_out

MUC2 MUC6 OTOG

2.26e-0519553SM00215
DomainLipin_N

LPIN3 LPIN2

2.55e-053552IPR007651
DomainLipin_mid

LPIN3 LPIN2

2.55e-053552PF16876
DomainTyr_kinase_insulin-like_rcpt

INSR INSRR

2.55e-053552IPR016246
DomainLipin_mid

LPIN3 LPIN2

2.55e-053552IPR031703
DomainLipin_N

LPIN3 LPIN2

2.55e-053552PF04571
DomainCT

MUC2 MUC6 OTOG

3.58e-0522553SM00041
DomainCys_knot_C

MUC2 MUC6 OTOG

5.31e-0525553IPR006207
DomainCTCK_2

MUC2 MUC6 OTOG

5.31e-0525553PS01225
DomainGrowth_fac_rcpt_

INSR INSRR LAMC1 LRP1B CRB1

9.47e-05156555IPR009030
DomainKringle-like

HGFAC LPA PLG

1.13e-0432553IPR013806
DomainLNS2

LPIN3 LPIN2

1.27e-046552PF08235
DomainLNS2

LPIN3 LPIN2

1.27e-046552IPR013209
DomainLNS2

LPIN3 LPIN2

1.27e-046552SM00775
DomainLNS2/PITP

LPIN3 LPIN2

1.27e-046552IPR031315
DomainFurin-like

INSR INSRR

1.77e-047552PF00757
DomainRcpt_L-dom

INSR INSRR

1.77e-047552IPR000494
DomainFurin-like_Cys-rich_dom

INSR INSRR

1.77e-047552IPR006211
DomainRecep_L_domain

INSR INSRR

1.77e-047552PF01030
Domain-

INSR INSRR

1.77e-0475523.80.20.20
DomainTRYPSIN_HIS

HGFAC LPA PLG OVCH1

2.40e-04103554IPR018114
DomainVWF_dom

MUC2 MUC6 OTOG

2.56e-0442553IPR001007
DomainTRYPSIN_SER

HGFAC LPA PLG OVCH1

2.68e-04106554PS00135
DomainTRYPSIN_HIS

HGFAC LPA PLG OVCH1

2.77e-04107554PS00134
DomainSO

TINAGL1 SUSD2

3.02e-049552SM00201
DomainPeptidase_S1A

HGFAC LPA PLG OVCH1

3.42e-04113554IPR001314
DomainTRYPSIN_DOM

HGFAC LPA PLG OVCH1

3.65e-04115554PS50240
DomainSomatomedin_B_dom

TINAGL1 SUSD2

3.77e-0410552IPR001212
DomainSMB_1

TINAGL1 SUSD2

3.77e-0410552PS00524
DomainSMB_2

TINAGL1 SUSD2

3.77e-0410552PS50958
DomainTryp_SPc

HGFAC LPA PLG OVCH1

3.90e-04117554SM00020
DomainCUB

LRP10 CDCP2 OVCH1

4.04e-0449553PF00431
DomainCUB

LRP10 CDCP2 OVCH1

4.29e-0450553SM00042
DomainTrypsin

HGFAC LPA PLG OVCH1

4.43e-04121554PF00089
DomainTrypsin_dom

HGFAC LPA PLG OVCH1

4.43e-04121554IPR001254
DomainTyr_kinase_rcpt_2_CS

INSR INSRR

4.60e-0411552IPR002011
DomainPeptidase_S1_PA

HGFAC LPA PLG OVCH1

4.71e-04123554IPR009003
Domain-

LRP10 CDCP2 OVCH1

4.82e-04525532.60.120.290
DomainCUB

LRP10 CDCP2 OVCH1

5.10e-0453553PS01180
DomainRECEPTOR_TYR_KIN_II

INSR INSRR

5.51e-0412552PS00239
DomainEGF_3

HGFAC TMEM8B LRP1B CRB1 OTOG

6.30e-04235555PS50026
DomainEGF

HGFAC TMEM8B LAMC1 LRP1B CRB1

6.30e-04235555SM00181
DomainCUB_dom

LRP10 CDCP2 OVCH1

6.32e-0457553IPR000859
DomainEGF-like_dom

HGFAC LAMC1 LRP1B CRB1 OTOG

8.17e-04249555IPR000742
DomainEGF_1

HGFAC TMEM8B LAMC1 LRP1B CRB1

9.09e-04255555PS00022
DomainEGF-like_CS

HGFAC TMEM8B LAMC1 LRP1B CRB1

1.01e-03261555IPR013032
DomainEGF_2

HGFAC TMEM8B LAMC1 LRP1B CRB1

1.08e-03265555PS01186
DomainFurin_repeat

INSR INSRR

1.26e-0318552IPR006212
DomainFU

INSR INSRR

1.26e-0318552SM00261
DomainTRYPSIN_SER

HGFAC PLG OVCH1

2.37e-0390553IPR033116
PathwayREACTOME_SYNTHESIS_OF_PE

LPIN3 LPIN2

4.35e-0412372MM14586
PathwayREACTOME_TRIGLYCERIDE_BIOSYNTHESIS

LPIN3 LPIN2

4.35e-0412372MM15447
PathwayREACTOME_DEPOLYMERIZATION_OF_THE_NUCLEAR_LAMINA

LPIN3 LPIN2

4.35e-0412372MM15105
PathwayBIOCARTA_FIBRINOLYSIS_PATHWAY

LPA PLG

4.35e-0412372MM1398
PathwayREACTOME_SYNTHESIS_OF_PE

LPIN3 LPIN2

5.13e-0413372M656
PathwayBIOCARTA_PLATELETAPP_PATHWAY

LPA PLG

5.98e-0414372MM1458
PathwayREACTOME_TRIGLYCERIDE_BIOSYNTHESIS

LPIN3 LPIN2

5.98e-0414372M619
PathwayREACTOME_DEPOLYMERIZATION_OF_THE_NUCLEAR_LAMINA

LPIN3 LPIN2

6.89e-0415372M27360
PathwayREACTOME_DISSOLUTION_OF_FIBRIN_CLOT

LPA PLG

6.89e-0415372MM15450
PathwayWP_BDNF_PATHWAY

LPA PLG

7.86e-0416372MM15816
PathwayWP_CONGENITAL_GENERALIZED_LIPODYSTROPHY

LPIN3 LPIN2

9.99e-0418372M42546
PathwayWP_ETHER_LIPID_BIOSYNTHESIS

LPIN3 LPIN2

1.24e-0320372M46451
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC2 MUC6

1.36e-0321372MM15706
PathwayWP_NANOPARTICLE_TRIGGERED_AUTOPHAGIC_CELL_DEATH

ATG7 INSR

1.64e-0323372M39325
PathwayREACTOME_TRIGLYCERIDE_METABOLISM

LPIN3 LPIN2

1.64e-0323372MM15575
PathwayWP_BLOOD_CLOTTING_CASCADE

LPA PLG

1.64e-0323372MM15936
Pubmed

Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7.

SCAMP5 SCAMP1 SCAMP2

1.67e-08457315840657
Pubmed

Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.

LPA PLG LPAL2

1.67e-08457321900290
Pubmed

Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions.

SCAMP5 SCAMP1 SCAMP2

4.16e-08557311050114
Pubmed

Localization of the Mas proto-oncogene to a densely marked region of mouse chromosome 17 associated with genomic imprinting.

MAS1 LPA PLG

4.16e-0855731612602
Pubmed

Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes.

MAS1 LPA PLG

2.32e-07857311562346
Pubmed

High-resolution genetic analysis of a deletion on mouse chromosome 17 extending over the fused, tufted, and homeobox Nkx2-5 loci.

MAS1 LPA PLG

2.32e-0785737894168
Pubmed

Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements.

MAS1 LPA PLG

2.32e-07857316204191
Pubmed

Tissue-specific regulation of Igf2r/Airn imprinting during gastrulation.

MAS1 LPA PLG

3.48e-07957325918552
Pubmed

Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r gene.

MAS1 LPA PLG

6.82e-07115739268631
Pubmed

Genetic analysis of the organic cation transporter genes Orct2/Slc22a2 and Orct3/Slc22a3 reduces the critical region for the t haplotype mutant t(w73) to 200 kb.

MAS1 LPA PLG

1.50e-061457311641723
Pubmed

Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruption.

MAS1 LPA PLG

1.87e-061557324090483
Pubmed

Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice.

LPA PLG

2.64e-06257231690812
Pubmed

Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.

LPA PLG

2.64e-06257230254165
Pubmed

Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells.

INSR INSRR

2.64e-0625728916919
Pubmed

Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice.

LPA PLG

2.64e-06257238328826
Pubmed

Reduced transplant arteriosclerosis in plasminogen-deficient mice.

LPA PLG

2.64e-0625729819364
Pubmed

Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice.

LPA PLG

2.64e-06257210634603
Pubmed

Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis.

LPA PLG

2.64e-06257223943648
Pubmed

In vivo plasminogen deficiency reduces fat accumulation.

LPA PLG

2.64e-06257212083480
Pubmed

Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice.

LPA PLG

2.64e-06257218420257
Pubmed

Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.

LPA PLG

2.64e-0625727705657
Pubmed

Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin.

LPA PLG

2.64e-06257223041318
Pubmed

Plasminogen alleles influence susceptibility to invasive aspergillosis.

LPA PLG

2.64e-06257218566672
Pubmed

A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis.

LPA PLG

2.64e-06257219752236
Pubmed

Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.

LPA PLG

2.64e-0625726216475
Pubmed

The generation and characterization of mice expressing a plasmin-inactivating active site mutation.

LPA PLG

2.64e-06257220653841
Pubmed

Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice.

LPA PLG

2.64e-06257212428098
Pubmed

Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus.

LPA PLG

2.64e-06257220440070
Pubmed

Plasminogen deficiency causes reduced corticospinal axonal plasticity and functional recovery after stroke in mice.

LPA PLG

2.64e-06257224732409
Pubmed

SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia.

SCAMP5 SCAMP2

2.64e-06257234426610
Pubmed

A central role for plasminogen in the inflammatory response to biomaterials.

LPA PLG

2.64e-06257215456492
Pubmed

Plasminogen promotes macrophage phagocytosis in mice.

LPA PLG

2.64e-06257224876560
Pubmed

Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice.

LPA PLG

2.64e-06257224574269
Pubmed

Spontaneous development of otitis media in plasminogen-deficient mice.

LPA PLG

2.64e-06257216956791
Pubmed

Staphylococcus aureus manganese transport protein C (MntC) is an extracellular matrix- and plasminogen-binding protein.

LPA PLG

2.64e-06257225409527
Pubmed

The mouse plasminogen locus maps to the recombination breakpoints of the tLub2 and TtOrl partial t haplotypes but is not at the tw73 locus.

LPA PLG

2.64e-0625721543918
Pubmed

Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen.

LPA PLG

2.64e-0625728704243
Pubmed

Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.

LPA PLG

2.64e-06257217267741
Pubmed

Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.

LPA PLG

2.64e-06257223702659
Pubmed

Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen on the surface of vascular endothelial and smooth muscle cells.

LPA PLG

2.64e-06257229990619
Pubmed

Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vector.

LPA PLG

2.64e-06257217293777
Pubmed

Role of secretory carrier membrane protein SCAMP2 in granule exocytosis.

SCAMP1 SCAMP2

2.64e-06257212475951
Pubmed

Preserved pancreatic beta-cell development and function in mice lacking the insulin receptor-related receptor.

INSR INSRR

2.64e-06257211463843
Pubmed

Plasminogen plays a crucial role in bone repair.

LPA PLG

2.64e-06257223456978
Pubmed

Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction.

LPA PLG

2.64e-06257210854210
Pubmed

Gender affects skin wound healing in plasminogen deficient mice.

LPA PLG

2.64e-06257223527289
Pubmed

Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation.

LPA PLG

2.64e-06257222079981
Pubmed

Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice.

LPA PLG

2.64e-0625729490683
Pubmed

The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals.

MUC2 MUC6

2.64e-06257230504806
Pubmed

Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity.

LPA PLG

2.64e-06257216481742
Pubmed

Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen: a novel mechanism for lipoprotein(a)-mediated inhibition of plasminogen activation.

LPA PLG

2.64e-06257218983515
Pubmed

Plasminogen Regulates Fracture Repair by Promoting the Functions of Periosteal Mesenchymal Progenitors.

LPA PLG

2.64e-06257234378815
Pubmed

Plasmin generation plays different roles in the formation and removal of arterial and venous thrombus in mice.

LPA PLG

2.64e-06257211848464
Pubmed

Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.

LPA PLG

2.64e-0625727586361
Pubmed

Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function.

LPA PLG

2.64e-06257221239499
Pubmed

Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice.

LPA PLG

2.64e-06257210642175
Pubmed

Plasminogen mRNA induction in the mouse brain after kainate excitation: codistribution with plasminogen activator inhibitor-2 (PAI-2) mRNA.

LPA PLG

2.64e-06257212225871
Pubmed

Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice.

LPA PLG

2.64e-0625729770530
Pubmed

Plasminogen activation is required for the development of radiation-induced dermatitis.

LPA PLG

2.64e-06257230323258
Pubmed

Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression.

LPA PLG

2.64e-06257237971174
Pubmed

The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.

LPA PLG

2.64e-0625729884337
Pubmed

Colonic Lesions, Cytokine Profiles, and Gut Microbiota in Plasminogen-Deficient Mice.

LPA PLG

2.64e-06257226473342
Pubmed

The complete genomic organization of the human MUC6 and MUC2 mucin genes.

MUC2 MUC6

2.64e-06257215081123
Pubmed

Nonfibrinolytic functions of plasminogen.

LPA PLG

2.64e-06257210816371
Pubmed

High-fat Diet Alters the Glycosylation Patterns of Duodenal Mucins in a Murine Model.

MUC2 MUC6

2.64e-06257232141795
Pubmed

MUC2 and MUC6 apomucins expression in human gastric neoplasm: an immunohistochemical analysis.

MUC2 MUC6

2.64e-06257220878553
Pubmed

Plasminogen is a critical regulator of cutaneous wound healing.

LPA PLG

2.64e-06257226791370
Pubmed

Selection of mutant µplasmin for amyloid-β cleavage in vivo.

LPA PLG

2.64e-06257232694536
Pubmed

Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.

LPA PLG

2.64e-0625727525077
Pubmed

Contrasting roles of plasminogen deficiency in different rheumatoid arthritis models.

LPA PLG

2.64e-06257216052596
Pubmed

Functional corpora lutea are formed in matrix metalloproteinase inhibitor-treated plasminogen-deficient mice.

LPA PLG

2.64e-06257217122079
Pubmed

Role of plasminogen in propagation of scrapie.

LPA PLG

2.64e-06257216103174
Pubmed

Differential expression of oxidized/native lipoprotein(a) and plasminogen in human carotid and cerebral artery plaques.

LPA PLG

2.64e-06257221300353
Pubmed

Beta-amyloid (Abeta) causes detachment of N1E-115 neuroblastoma cells by acting as a scaffold for cell-associated plasminogen activation.

LPA PLG

2.64e-06257215737740
Pubmed

Selective behaviors altered in plasminogen-deficient mice are reconstituted with intracerebroventricular injection of plasminogen.

LPA PLG

2.64e-06257211306011
Pubmed

Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression.

LPA PLG

2.64e-06257212149246
Pubmed

Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis.

LPA PLG

2.64e-06257222056679
Pubmed

Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis.

LPA PLG

2.64e-06257218311818
Pubmed

Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus.

LPA PLG

2.64e-06257221190118
Pubmed

The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.

LPA PLG

2.64e-06257218039665
Pubmed

Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice.

LPA PLG

2.64e-0625729671388
Pubmed

A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response.

LPA PLG

2.64e-06257218997104
Pubmed

Growth and behavioral development in plasminogen gene-targeted mice.

LPA PLG

2.64e-06257210885855
Pubmed

Cellular density regulation of plasminogen gene expression in mouse hepatocytes.

LPA PLG

2.64e-06257212559391
Pubmed

Physiologic variations in blood plasminogen levels affect outcomes after acute cerebral thromboembolism in mice: a pathophysiologic role for microvascular thrombosis.

LPA PLG

2.64e-06257227319402
Pubmed

Plasminogen is a critical host pathogenicity factor for group A streptococcal infection.

LPA PLG

2.64e-06257215333838
Pubmed

Apo(a) promotes thrombosis in a vascular injury model by a mechanism independent of plasminogen.

LPA PLG

2.64e-06257216150044
Pubmed

Plasminogen has a broad extrahepatic distribution.

LPA PLG

2.64e-06257211916082
Pubmed

Unaltered prion protein cleavage in plasminogen-deficient mice.

LPA PLG

2.64e-06257216543819
Pubmed

Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice.

LPA PLG

2.64e-06257234423816
Pubmed

Delayed invasion of the kidney and brain by Borrelia crocidurae in plasminogen-deficient mice.

LPA PLG

2.64e-06257211500461
Pubmed

Growth of human squamous cell carcinoma xenografts in mice is inhibited by local angiostatin gene therapy.

LPA PLG

2.64e-06257212167431
Pubmed

Impaired wound healing in mice with a disrupted plasminogen gene.

LPA PLG

2.64e-0625728612226
Pubmed

Role of plasminogen activation in neuronal organization and survival.

LPA PLG

2.64e-06257219683575
Pubmed

Ovulation in plasminogen-deficient mice.

LPA PLG

2.64e-06257210537128
Pubmed

Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.

LPA PLG

2.64e-06257223555246
Pubmed

Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes.

LPA PLG

2.64e-06257218685433
Pubmed

Plasminogen mediates communication between the peripheral and central immune systems during systemic immune challenge with lipopolysaccharide.

LPA PLG

2.64e-06257231462325
Pubmed

Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.

LPA PLG

2.64e-0625729242524
Pubmed

Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice.

LPA PLG

7.91e-06357216818777
InteractionSLC9A7 interactions

SCAMP5 SCAMP1 SCAMP2

4.39e-0612563int:SLC9A7
CytobandEnsembl 112 genes in cytogenetic band chr6q26

LPA PLG

1.80e-0416572chr6q26
Cytoband6q26

LPA PLG

2.29e-04185726q26
CytobandEnsembl 112 genes in cytogenetic band chr14q23

TMEM30B FNTB JKAMP

5.80e-04130573chr14q23
Cytoband14q23.1

TMEM30B JKAMP

1.58e-034757214q23.1
Cytoband7p22.1

RSPH10B2 RSPH10B

1.58e-03475727p22.1
Cytoband9p13.3

TMEM8B SPAG8

3.97e-03755729p13.3
GeneFamilySecretory carrier membrane proteins

SCAMP5 SCAMP1 SCAMP2

4.11e-085303735
GeneFamilyLipins

LPIN3 LPIN2

7.98e-0633021043
GeneFamilyLow density lipoprotein receptors

LRP10 LRP1B

2.05e-0413302634
GeneFamilyCD molecules|Mucins

MUC2 MUC6

5.48e-0421302648
GeneFamilyReceptor Tyrosine Kinases|CD molecules

INSR INSRR

2.00e-0340302321
GeneFamilyPHD finger proteins

ING3 PHF20L1

9.74e-039030288
GeneFamilyFibronectin type III domain containing

INSR INSRR

2.88e-02160302555
CoexpressionPILON_KLF1_TARGETS_UP

ABCC3 HGFAC RHBDF1 LPA INSR LPIN2 IGSF1 PLG

2.13e-05541578MM1061
CoexpressionGSE9960_HEALTHY_VS_GRAM_NEG_AND_POS_SEPSIS_PBMC_UP

SUSD2 INSRR SPAG8 CFAP69 MUC6

5.43e-05187575M7123
CoexpressionNABA_MATRISOME

TINAGL1 CRISPLD2 HGFAC LPA LAMC1 CDCP2 PLG MUC2 MUC6 OTOG

5.65e-0510085710MM17056
CoexpressionNABA_ECM_GLYCOPROTEINS

TINAGL1 CRISPLD2 LAMC1 CDCP2 OTOG

6.00e-05191575MM17059
CoexpressionNABA_MATRISOME

TINAGL1 CRISPLD2 HGFAC LPA LAMC1 CDCP2 PLG MUC2 MUC6 OTOG

6.55e-0510265710M5889
CoexpressionNABA_ECM_GLYCOPROTEINS

TINAGL1 CRISPLD2 LAMC1 CDCP2 OTOG

6.78e-05196575M3008
CoexpressionRANKIN_ANGIOGENIC_TARGETS_OF_VHL_HIF2A_UP

LPA PLG

6.93e-056572MM555
CoexpressionGSE11924_TH2_VS_TH17_CD4_TCELL_UP

MYO9A SCAMP5 LPIN2 IGSF1 TTLL13

7.29e-05199575M3164
CoexpressionPILON_KLF1_TARGETS_UP

ABCC3 HGFAC RHBDF1 INSR LPIN2 IGSF1 PLG

1.06e-04503577M2226
CoexpressionAIZARANI_LIVER_C7_EPCAM_POS_BILE_DUCT_CELLS_2

ABCC3 RHBDF1 LRP10 LAMC1 MUC6

1.14e-04219575M39111
CoexpressionCAIRO_LIVER_DEVELOPMENT_DN

TMEM30B HGFAC LPA LPIN2 PLG

1.72e-04239575MM1274
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 GXYLT2 NOX4 LAMC1 OVCH1

2.75e-06172575e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCellfacs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LPIN3 CRISPLD2 MAS1 NOX4 LAMC1

3.62e-06182575dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCellfacs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LPIN3 CRISPLD2 MAS1 NOX4 LAMC1

3.62e-06182575c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LPIN3 CRISPLD2 GXYLT2 NOX4 IGSF1

3.72e-0618357506a68fa2be36448064f4668be24a5b85ad85c6e8
ToppCellfacs-Liver-Hepatocytes-24m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM30B ABCC3 HGFAC NOX4 PLG

3.72e-06183575d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCellfacs-Thymus-nan-3m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GXYLT2 NOX4 PLG CRB1

3.12e-05140574115bd770a9d5e6f007a9aa0eadf5dba46d500107
ToppCellfacs-Thymus-nan-3m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GXYLT2 NOX4 PLG CRB1

3.12e-0514057422d126e80bf7d9c0ca6ec686b5cc66fa584a1ab6
ToppCellfacs-Thymus-nan-3m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GXYLT2 NOX4 PLG CRB1

3.12e-0514057462d1ef8cb78618ed89cac7ec89d7f54de06a90c7
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RHBDF1 TMEM8B MAS1 RSPH10B

4.64e-05155574a16e3a72badafa78a3efc4f4ab62396f0ce99d1e
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B0|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

RHBDF1 TMEM8B MAS1 RSPH10B

5.92e-05165574ebd668e87e5961a124d1d6fc25d1f03e4af05cd4
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Radial_glial-RGCs_early_2|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

TINAGL1 RHBDF1 LRP10 INSRR

5.92e-05165574e460e03992781073cd836a655f15dda3157cea55
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

CRISPLD2 INSRR NOX4 LAMC1

6.50e-051695746373562ab3b1765060212a6a53d6543e7e942e80
ToppCellAT1-AT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

ABCC3 SUSD2 IGSF1 MUC6

6.96e-051725740be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCellHealthy/Control-pDC|Healthy/Control / Disease group and Cell class

TINAGL1 GXYLT2 SCAMP5 TMEM8B

7.94e-05178574072b346c6bbd63f00efaceda486400a669b3ec48
ToppCellLA-01._Fibroblast_I|LA / Chamber and Cluster_Paper

CRISPLD2 INSRR NOX4 LAMC1

8.12e-05179574dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC3 SUSD2 INSR PLG

8.84e-0518357485446581999cd66b171c4f69b7eb8b0bbbaa8617
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TINAGL1 CRISPLD2 GADL1 LRP1B

1.02e-04190574938d1f66094b1c94606e0d40213a39e5112f3322
ToppCellfacs-Heart-LV-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRISPLD2 RHBDF1 SUSD2 LAMC1

1.04e-04191574b7a57691a4742070cee640e285c1f4d0da95baf1
ToppCellLA|World / Chamber and Cluster_Paper

CRISPLD2 NOX4 LAMC1 LRP1B

1.09e-04193574d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TINAGL1 TMEM233 INSR NOX4

1.09e-041935743f8280ef849d95b2fcea5e6824b95a07febc96d0
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRISPLD2 NOX4 LAMC1 IGSF1

1.09e-041935747c0d84b92470bfda2db1e5007feee7c1235a0a78
ToppCellfacs-Lung-nan-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRISPLD2 GXYLT2 NOX4 LAMC1

1.09e-04193574d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 GXYLT2 NOX4 LAMC1

1.13e-04195574f54bc4454270ff06e85596f98199372b50d0179f
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

SPAG8 CFAP69 SOAT2 RSPH10B

1.13e-0419557460067b5359174f0d1a8b5748bfc0690762e9e740
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

HGFAC MUC6 SOAT2

1.17e-04745730288a3f4eafbc359d01cde4ba58f946dd07c77cb
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

HGFAC MUC6 SOAT2

1.17e-047457357884ade66fe39398351685189df5efd7aea0aab
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

HGFAC MUC6 SOAT2

1.17e-047457313093139a75bfe11f6b032c9fb402efcc703551c
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

HGFAC MUC6 SOAT2

1.17e-04745737f7de9e8142d2435391ee965cee5628e412f0705
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TINAGL1 TMEM233 INSR NOX4

1.17e-0419757462c0a90869431e582bb7bb329e0b0cc59123d3d1
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TMEM233 INSR NOX4 LAMC1

1.17e-04197574a312d9cf4ced949307eb9620be4eed926300b892
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TINAGL1 TMEM233 INSR NOX4

1.17e-0419757416f0eb047df9d702518f82ee99c6e7dc1350b2fb
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TINAGL1 INSR NOX4 LAMC1

1.17e-041975749244f087ba4b60fdc81d54ce91860de715b3e12c
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 GXYLT2 NOX4 LAMC1

1.17e-0419757471786e9432e2d649f5d86f639abb25e7102deb67
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TINAGL1 TMEM233 INSR NOX4

1.17e-041975749e948b2e0f7e426f1e6f95bbbf4282fbddc2b99d
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_ciliated-Deuterosomal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RSPH10B2 STIL SPAG8 RSPH10B

1.20e-04198574f31790442ef142f1c0c49bf3daf2d0efb193d2c9
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TINAGL1 INSR NOX4 LAMC1

1.20e-041985747cddd474416651088a4e08edfc0ac420ff10a5fe
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 GXYLT2 NOX4 LAMC1

1.22e-041995741fd7bbb8727607e6507848602a19bc86882ef2d5
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 GXYLT2 NOX4 LAMC1

1.22e-041995749672230aa0bc6a7289050c955f5154ca183a5159
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 GXYLT2 NOX4 LAMC1

1.22e-04199574e18abe678da293bd01fae55e2f9ab6fdd643d02d
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TMEM233 INSR NOX4 LAMC1

1.22e-04199574463ba77dc4c85eebb343f29a42c7ac889b0497c9
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TMEM233 INSR NOX4 LAMC1

1.22e-0419957463c01e8961f48ed1bed4ab619cacf318cd6de7b9
ToppCellcellseq2-Mesenchymal|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TINAGL1 CRISPLD2 SUSD2 LAMC1

1.24e-042005746b558cce0d6047c7e85f428adff80c5ca3084ea4
ToppCellfacs-Brain_Non-Myeloid-Hippocampus|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WSCD1 LRP10 SCAMP5 LDAH

1.24e-04200574fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TINAGL1 TMEM233 INSR NOX4

1.24e-04200574061ba851f941c616ddb462512e826c412881c3ce
Drugprobucol

LRP10 LPA NOX4 PLG LPAL2 LRP1B SOAT2

1.59e-07162577CID000004912
DrugPF-00562151-00 [351320-12-2]; Up 200; 10uM; MCF7; HT_HG-U133A

WSCD1 ABCC3 TMEM8B PLG SPAG8 CFAP69

8.96e-061945765954_UP
DrugAminocaproic Acid

LPA PLG

1.84e-053572DB00513
Drugmangrove

LRP10 LPA INSR ALOXE3 PLG LPAL2 LRP1B SOAT2

2.05e-05468578CID000000965
Drugsodium linoleate

RHBDF1 LRP10 LPA ALOXE3 LPAL2 LRP1B SOAT2

2.25e-05342577CID000003931
DrugAC1L1J6H

ABCC3 LRP10 LPA LPAL2 LRP1B SOAT2

2.72e-05236576CID000004889
Drugezetimibe

ABCC3 LRP10 LPA LRP1B SOAT2

3.35e-05147575CID000150311
Diseasecholesteryl esters to total lipids in small LDL percentage

HGFAC LPA PLG LPAL2 SOAT2

1.65e-0842565EFO_0022255
Diseaselipoprotein A measurement, apolipoprotein A 1 measurement

LPA PLG LPAL2

2.25e-077563EFO_0004614, EFO_0006925
Diseaselipoprotein A measurement

MAS1 LPA PLG LPAL2 SOAT2

2.36e-06112565EFO_0006925
Diseasefree cholesterol to total lipids in large HDL percentage

HGFAC LPA PLG LPAL2

3.97e-0656564EFO_0022279
Diseaselow density lipoprotein particle size measurement

LPA PLG LPAL2 SOAT2

4.57e-0658564EFO_0008593
Diseasevery low density lipoprotein particle size measurement

HGFAC LPA INSR PLG LPAL2

5.48e-06133565EFO_0008594
Diseasetriglycerides in small VLDL measurement

HGFAC LPA PLG LPAL2

5.60e-0661564EFO_0022145
Diseasetriglycerides to total lipids in very large HDL percentage

HGFAC LPA PLG LPAL2

5.98e-0662564EFO_0022339
Diseasetriglycerides in small HDL measurement

HGFAC LPA PLG LPAL2

5.98e-0662564EFO_0022158
Diseasephospholipids in large VLDL measurement

HGFAC LPA PLG LPAL2

5.98e-0662564EFO_0022169
Diseasefree cholesterol in very large HDL measurement

HGFAC LPA PLG LPAL2

5.98e-0662564EFO_0022273
Diseasefree cholesterol to total lipids in medium LDL percentage

HGFAC LPA PLG LPAL2

6.38e-0663564EFO_0022283
Diseasetriglycerides in small LDL measurement

HGFAC LPA PLG LPAL2

7.23e-0665564EFO_0022323
Diseasetotal lipids in very large HDL measurement

HGFAC LPA PLG LPAL2

7.68e-0666564EFO_0022312
Diseasephospholipids in very large HDL measurement

HGFAC LPA PLG LPAL2

7.68e-0666564EFO_0022298
Diseasetriglycerides to phosphoglycerides ratio

HGFAC LPA PLG LPAL2

8.65e-0668564EFO_0022327
Diseasefree cholesterol in large VLDL measurement

HGFAC LPA PLG LPAL2

8.65e-0668564EFO_0022265
Diseasetriglycerides to total lipids in very small VLDL percentage

HGFAC LPA PLG LPAL2

9.17e-0669564EFO_0022341
Diseasecholesterol in very large HDL measurement

HGFAC LPA PLG LPAL2

9.17e-0669564EFO_0022229
Diseasemyoglobinuria (implicated_via_orthology)

LPIN3 LPIN2

1.06e-053562DOID:0080108 (implicated_via_orthology)
Diseaselow density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

HGFAC LPA PLG LPAL2 SOAT2

1.08e-05153565EFO_0004611, EFO_0020946
Diseaselow density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

HGFAC LPA PLG LPAL2 SOAT2

1.08e-05153565EFO_0004611, EFO_0020944
Diseasefree cholesterol to total lipids in large LDL percentage

HGFAC LPA PLG LPAL2

1.21e-0574564EFO_0022280
Diseasemonounsaturated fatty acids; 16:1, 18:1 measurement

HGFAC LPA PLG LPAL2

1.49e-0578564EFO_0022187
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement

HGFAC LPA PLG LPAL2

3.26e-0595564EFO_0004529, EFO_0008317, EFO_0008596
Diseasechylomicron measurement, triglyceride measurement, very low density lipoprotein cholesterol measurement

HGFAC LPA PLG LPAL2

3.39e-0596564EFO_0004530, EFO_0008317, EFO_0008596
Diseasechronic kidney disease, APOL1 risk genotype carrier status

LPA PLG

3.52e-055562EFO_0003884, EFO_0009324
Diseaseplasma plasminogen measurement

LPA PLG

3.52e-055562EFO_0006309
Diseasemucinous adenocarcinoma (is_marker_for)

MUC2 MUC6

3.52e-055562DOID:3030 (is_marker_for)
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

LPA PLG LPAL2

3.72e-0534563EFO_0008317, EFO_0008596, EFO_0020944
Diseasechylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

LPA PLG LPAL2

3.72e-0534563EFO_0008317, EFO_0008596, EFO_0020947
Diseasetriglyceride measurement, alcohol drinking

HGFAC LPA INSR PLG

3.83e-0599564EFO_0004329, EFO_0004530
Diseasetriglyceride measurement, alcohol consumption measurement

HGFAC LPA INSR PLG

4.14e-05101564EFO_0004530, EFO_0007878
Diseasecholesteryl esters to total lipids in medium LDL percentage

HGFAC LPA PLG

4.81e-0537563EFO_0022252
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement

HGFAC LPA PLG LPAL2

5.00e-05106564EFO_0008317, EFO_0008596
Diseaseangiostatin measurement

LPA PLG

5.28e-056562EFO_0008024
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipid measurement

HGFAC LPA PLG LPAL2

5.58e-05109564EFO_0004639, EFO_0008317, EFO_0008596
Diseaseaspirin use measurement

PCNX3 LPA LPAL2

5.64e-0539563EFO_0007013
Diseasecholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement

HGFAC LPA PLG LPAL2

5.78e-05110564EFO_0008317, EFO_0008596, EFO_0010351
Diseasefree cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement

HGFAC LPA PLG LPAL2

5.78e-05110564EFO_0008317, EFO_0008591, EFO_0008596
Diseasechylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement

HGFAC LPA PLG LPAL2

5.78e-05110564EFO_0004574, EFO_0008317, EFO_0008596
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

HGFAC LPA INSR PLG LPAL2

6.17e-05220565EFO_0004529, EFO_0008317
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

HGFAC LPA INSR PLG LPAL2

6.44e-05222565EFO_0008317, EFO_0020943
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

HGFAC LPA INSR PLG LPAL2

6.72e-05224565EFO_0004530, EFO_0008317
Diseasephospholipids:total lipids ratio

HGFAC LPA PLG LPAL2 SOAT2

7.16e-05227565EFO_0020946
Diseasehigh grade glioma (implicated_via_orthology)

ATG7 INSR INSRR

8.11e-0544563DOID:3070 (implicated_via_orthology)
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

LPA PLG LPAL2

9.28e-0546563EFO_0008317, EFO_0008596, EFO_0020943
Diseasepolyunsaturated fatty acids to total fatty acids percentage

LPA PLG LPAL2

1.19e-0450563EFO_0022303
Diseasealcohol dependence (implicated_via_orthology)

INSR INSRR

1.26e-049562DOID:0050741 (implicated_via_orthology)
Diseasepolyunsaturated fatty acids to monounsaturated fatty acids ratio

LPA PLG LPAL2

1.26e-0451563EFO_0022302
Diseasecholesterol to total lipids in small HDL percentage

LPA PLG LPAL2

1.26e-0451563EFO_0022240
Diseasevery low density lipoprotein cholesterol measurement

HGFAC LPA INSR PLG LPAL2

1.35e-04260565EFO_0008317
Diseasetriglycerides in HDL measurement

LPA PLG LPAL2

1.42e-0453563EFO_0022317
Diseasefree cholesterol to total lipids in small LDL percentage

LPA PLG LPAL2

1.42e-0453563EFO_0022286
Diseasetriglycerides in medium HDL measurement

LPA PLG LPAL2

1.50e-0454563EFO_0022321
Diseasetriglycerides in medium VLDL measurement

HGFAC LPA LPAL2

1.58e-0455563EFO_0022155
Diseasecholesterol:total lipids ratio, low density lipoprotein cholesterol measurement

HGFAC LPA PLG SOAT2

1.64e-04144564EFO_0004611, EFO_0020943
Diseasetriglycerides in LDL measurement

HGFAC LPA PLG

1.67e-0456563EFO_0022320
Diseasetriglycerides in very large VLDL measurement

HGFAC LPA LPAL2

1.67e-0456563EFO_0022325
Diseasetriglycerides to total lipids in medium HDL percentage

LPA PLG LPAL2

1.67e-0456563EFO_0022333
Diseasetriglycerides in large VLDL measurement

HGFAC LPA LPAL2

1.67e-0456563EFO_0022178
Diseasecholesteryl esters to total lipids in medium HDL percentage

LPA PLG LPAL2

1.67e-0456563EFO_0022251
Diseasetriglyceride measurement, phospholipid measurement

HGFAC LPA PLG LPAL2

1.73e-04146564EFO_0004530, EFO_0004639
Diseasesleep disorder (implicated_via_orthology)

INSR INSRR

1.92e-0411562DOID:535 (implicated_via_orthology)
Diseasetriglycerides in VLDL measurement

HGFAC LPA LPAL2

1.95e-0459563EFO_0022326
Diseasetriglycerides to total lipids in small LDL percentage

LPA PLG LPAL2

1.95e-0459563EFO_0022337
Diseaseconcentration of chylomicrons and extremely large VLDL particles measurement

HGFAC LPA LPAL2

1.95e-0459563EFO_0022260
Diseaseautism spectrum disorder (implicated_via_orthology)

SCAMP5 SCAMP1 LAMC1 SCAMP2

2.02e-04152564DOID:0060041 (implicated_via_orthology)
Diseasetriglycerides to total lipids in large HDL percentage

LPA PLG LPAL2

2.05e-0460563EFO_0022330
Diseasecholesterol in chylomicrons and extremely large VLDL measurement

HGFAC LPA LPAL2

2.05e-0460563EFO_0021898
Diseasetotal lipids in VLDL measurement

HGFAC LPA LPAL2

2.05e-0460563EFO_0022314
Diseasecholesterol to total lipids in medium HDL percentage

LPA PLG LPAL2

2.05e-0460563EFO_0022237
Diseasefree cholesterol in very large VLDL measurement

HGFAC LPA LPAL2

2.16e-0461563EFO_0022274
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

HGFAC LPA PLG

2.16e-0461563EFO_0008317, EFO_0008596, EFO_0020946
Diseasetriglycerides in medium LDL measurement

HGFAC LPA PLG

2.26e-0462563EFO_0022322
Diseasetotal lipids in chylomicrons and extremely large VLDL measurement

HGFAC LPA LPAL2

2.26e-0462563EFO_0022306
Diseasetotal lipids in very large VLDL measurement

HGFAC LPA LPAL2

2.26e-0462563EFO_0022313
Diseasefree cholesterol in chylomicrons and extremely large VLDL measurement

HGFAC LPA LPAL2

2.26e-0462563EFO_0022263
Diseasephospholipids in very large VLDL measurement

HGFAC LPA LPAL2

2.26e-0462563EFO_0022299
Diseasetriglycerides to total lipids in medium VLDL percentage

LPA PLG LPAL2

2.37e-0463563EFO_0022335
Diseasecholesterol to total lipids in medium VLDL percentage

LPA PLG LPAL2

2.37e-0463563EFO_0022239
Diseasephospholipids in chylomicrons and extremely large VLDL measurement

HGFAC LPA LPAL2

2.37e-0463563EFO_0022292
Diseasecholesteryl esters to total lipids in medium VLDL percentage

LPA PLG LPAL2

2.49e-0464563EFO_0022253
Diseasecholesterol in very large VLDL measurement

HGFAC LPA LPAL2

2.60e-0465563EFO_0022230
Diseasetriglyceride measurement, low density lipoprotein cholesterol measurement

HGFAC LPA PLG LPAL2

2.82e-04166564EFO_0004530, EFO_0004611
Diseasetotal lipids in large VLDL

HGFAC LPA LPAL2

2.85e-0467563EFO_0022175
Diseasecholesterol to total lipids in very small VLDL percentage

LPA PLG LPAL2

2.85e-0467563EFO_0022245
DiseaseAbdominal Aortic Aneurysm

CRISPLD2 LPA LDAH

2.97e-0468563EFO_0004214
Diseasehigh density lipoprotein particle size measurement

HGFAC LPA PLG LPAL2

3.09e-04170564EFO_0008592
Diseasediabetic neuropathy (implicated_via_orthology)

INSR INSRR

3.17e-0414562DOID:9743 (implicated_via_orthology)
Diseasecholesteryl esters to total lipids in very small VLDL percentage

HGFAC LPA LPAL2

3.38e-0471563EFO_0022259
Diseasetriglycerides to total lipids in small HDL percentage

LPA PLG LPAL2

3.52e-0472563EFO_0022336
Diseasetriglycerides to total lipids in chylomicrons and extremely large VLDL percentage

LPA LPAL2

3.66e-0415562EFO_0022328
Diseaselipid metabolism disorder (implicated_via_orthology)

LPIN3 LPIN2

3.66e-0415562DOID:3146 (implicated_via_orthology)
Diseasefree cholesterol to total lipids in small VLDL percentage

LPA PLG LPAL2

3.97e-0475563EFO_0022287
Diseasepre-malignant neoplasm (biomarker_via_orthology)

INSR MUC2

4.72e-0417562DOID:0060071 (biomarker_via_orthology)
Diseasecholesterol to total lipids in chylomicrons and extremely large VLDL percentage

LPA LPAL2

4.72e-0417562EFO_0022232
Diseaseomega-6 polyunsaturated fatty acid measurement

HGFAC LPA PLG LPAL2

5.40e-04197564EFO_0005680
Diseaselow density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

HGFAC LPA PLG LPAL2

5.71e-04200564EFO_0004611, EFO_0020945
Diseasetriglycerides:total lipids ratio, high density lipoprotein cholesterol measurement

HGFAC LPA PLG LPAL2

6.38e-04206564EFO_0004612, EFO_0020947

Protein segments in the cluster

PeptideGeneStartEntry
FPRLYPYNTECSWLI

CDCP2

46

Q5VXM1
PCIYLWVALPCYLLY

ABCC3

41

O15438
CWEIYLAYCRPSAAP

RSPH10B

556

P0C881
CWEIYLAYCRPSAAP

RSPH10B2

556

B2RC85
WRTPAFCPIYCGFYN

MUC6

1121

Q6W4X9
EYSNFCYWREPLPAV

LPIN3

831

Q9BQK8
TYHVRGYCLPWDRPC

LRP10

301

Q7Z4F1
SLDPQAGYLYWIDCC

LRP1B

3136

Q9NZR2
CLSVLYPIWYRCHRP

MAS1

131

P04201
QECYRWKIYAPGFPC

ALOXE3

141

Q9BYJ1
VDWTYDPNEPRYCIC

ING3

351

Q9NXR8
NWVIAYSRPVYFCIC

PCNX3

851

Q9H6A9
WRTPDLCPIFCDYYN

MUC2

1111

Q02817
KDYTYPYPSECNPWC

CRISPLD2

136

Q9H0B8
ECLYVFPCQWNYRPD

GXYLT2

326

A0PJZ3
ETCPPPYYHFQDWRC

INSR

266

P06213
AYCRNPDNDERPWCY

HGFAC

336

Q04756
YYDGWLICEEPTCRN

POLA1

1341

P09884
WISGPLCLYCAERLY

NOX4

286

Q9NPH5
CSYRLQAYPDIWSEP

IGSF1

1226

Q8N6C5
YWFCYPALCLPESLP

ATG7

146

O95352
YRCSRWPCPNVVDCF

GJA8

181

P48165
NCYSNYPFPLTSWPC

GCM1

311

Q9NP62
PCSCAWYFSLPELFQ

TMEM30B

91

Q3MIR4
PYCYTRDPGVRWEYC

LPA

86

P08519
PYCYTRDPGVRWEYC

LPA

656

P08519
CYTRDPSVRWEYCNL

LPA

886

P08519
NYCRNPDAEIRPWCY

LPA

1101

P08519
YCRNPDAEISPWCYT

LPA

1216

P08519
NYCRNPDAEIRPWCY

LPA

1321

P08519
YCRNPDAEIRPWCYT

LPA

1436

P08519
ACPPGTYQYESWRCV

INSRR

261

P14616
DAYECLDASRPWLCY

FNTB

91

P49356
YNRSWPGCQECPACY

LAMC1

1021

P11047
EYANICFWYIPPSLR

GADL1

436

Q6ZQY3
AYLYEERWTPPCCLR

FKRP

306

Q9H9S5
WLSYQCDCHRPYEGP

CRB1

691

P82279
IWCCILGCYPSEDYF

CFAP69

591

A5D8W1
FTPCSYVCWFRPIYK

SCAMP5

81

Q8TAC9
VDWRTPRLCPYDCDF

OTOG

1231

Q6ZRI0
YPICEWRYDACASPC

OTOG

1406

Q6ZRI0
YICYICRDPPGQRWS

PHF20L1

721

A8MW92
FYYCCLWAPDCPRYM

SUSD2

416

Q9UGT4
IYPVLGTYWDNCNRC

TINAGL1

111

Q9GZM7
NYLWLTIVSCFCPAY

TMEM233

36

B4DJY2
CYETLPRGQCLLYNW

SPAG8

271

Q99932
LLSYFPSPYQRWICC

BMT2

246

Q1RMZ1
YCRNPDCSAGPWCYT

LPAL2

76

Q16609
YPDLYPSNIRCHWFI

OVCH1

436

Q7RTY7
LFYVYPVRCEWCEFL

RHBDF1

821

Q96CC6
FLLFTPCSFVCWYRP

SCAMP1

191

O15126
PCSFVCWYRPLYGAF

SCAMP1

196

O15126
FLIFTPCAFLCWYRP

SCAMP2

191

O15127
PCAFLCWYRPIYKAF

SCAMP2

196

O15127
RETEQCWVQPPYKYC

WFDC9

36

Q8NEX5
PWCYTTNPRKLYDYC

PLG

541

P00747
LYCQEWYARRHCPLP

SOAT2

491

O75908
WNCCFIPLRLVFPYQ

CNGB3

231

Q9NQW8
YSPQVWACCLRYIFN

STIL

271

Q15468
CYPPTWRRWLFYLCP

TMEM8B

371

A6NDV4
PYRCPWCDYRSNCAE

ZNF407

1741

Q9C0G0
PLAILRGWECYCAYP

WSCD1

286

Q658N2
RGWECYCAYPTPRFN

WSCD1

291

Q658N2
LYPSEYNIFPRTWCL

TTLL13

166

A6NNM8
CQPCTESPELYDWLY

JKAMP

46

Q9P055
CKLTFYYGTIDPWCP

LDAH

261

Q9H6V9
AFPCPEFSSFCYWRD

LPIN2

871

Q92539
PLRQSWDDYCYDSEP

MYO9A

371

B2RTY4