Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRho-dependent protein serine/threonine kinase activity

ROCK2 ROCK1

5.66e-062482GO:0072518
GeneOntologyBiologicalProcessnegative regulation of bicellular tight junction assembly

ROCK2 ROCK1 IKBKB

3.86e-077473GO:1903347
GeneOntologyBiologicalProcesscortical actin cytoskeleton organization

ROCK2 ROCK1 IKBKB IQGAP3

3.29e-0645474GO:0030866
GeneOntologyBiologicalProcesscortical cytoskeleton organization

ROCK2 ROCK1 IKBKB IQGAP3

8.55e-0657474GO:0030865
GeneOntologyBiologicalProcessregulation of endothelial cell development

ROCK2 ROCK1 IKBKB

1.23e-0520473GO:1901550
GeneOntologyBiologicalProcessregulation of establishment of endothelial barrier

ROCK2 ROCK1 IKBKB

1.23e-0520473GO:1903140
GeneOntologyBiologicalProcessactomyosin structure organization

ROCK2 NRAP ROCK1 CGNL1 S1PR1 IQGAP3

1.64e-05239476GO:0031032
GeneOntologyBiologicalProcessregulation of establishment of cell polarity

ROCK2 ROCK1 ANKFN1

2.46e-0525473GO:2000114
GeneOntologyBiologicalProcessregulation of angiotensin-activated signaling pathway

ROCK2 ROCK1

3.04e-054472GO:0110061
GeneOntologyBiologicalProcessregulation of bicellular tight junction assembly

ROCK2 ROCK1 IKBKB

3.49e-0528473GO:2000810
GeneOntologyBiologicalProcessnegative regulation of phosphatase activity

ROCK2 ROCK1 IKBKB

4.31e-0530473GO:0010923
GeneOntologyBiologicalProcessregulation of establishment or maintenance of cell polarity

ROCK2 ROCK1 ANKFN1

4.31e-0530473GO:0032878
GeneOntologyBiologicalProcessmitotic cytokinesis

ROCK2 ROCK1 CIT IQGAP3

6.47e-0595474GO:0000281
GeneOntologyBiologicalProcessactin cytoskeleton organization

ROCK2 CTTNBP2 NRAP ROCK1 CGNL1 IKBKB CIT S1PR1 IQGAP3

7.08e-05803479GO:0030036
GeneOntologyBiologicalProcessregulation of stress fiber assembly

ROCK2 ROCK1 CGNL1 S1PR1

1.03e-04107474GO:0051492
GeneOntologyBiologicalProcessnegative regulation of cell junction assembly

ROCK2 ROCK1 IKBKB

1.11e-0441473GO:1901889
GeneOntologyBiologicalProcessnegative regulation of dephosphorylation

ROCK2 ROCK1 IKBKB

1.38e-0444473GO:0035305
GeneOntologyBiologicalProcessactin filament organization

ROCK2 NRAP ROCK1 CGNL1 CIT S1PR1 IQGAP3

1.43e-04509477GO:0007015
GeneOntologyBiologicalProcessregulation of actomyosin structure organization

ROCK2 ROCK1 CGNL1 S1PR1

1.71e-04122474GO:0110020
GeneOntologyBiologicalProcessregulation of actin filament bundle assembly

ROCK2 ROCK1 CGNL1 S1PR1

1.76e-04123474GO:0032231
GeneOntologyBiologicalProcessactin filament-based process

ROCK2 CTTNBP2 NRAP ROCK1 CGNL1 IKBKB CIT S1PR1 IQGAP3

1.86e-04912479GO:0030029
GeneOntologyBiologicalProcesscytoskeleton-dependent cytokinesis

ROCK2 ROCK1 CIT IQGAP3

1.99e-04127474GO:0061640
GeneOntologyBiologicalProcesscontractile actin filament bundle assembly

ROCK2 ROCK1 CGNL1 S1PR1

1.99e-04127474GO:0030038
GeneOntologyBiologicalProcessstress fiber assembly

ROCK2 ROCK1 CGNL1 S1PR1

1.99e-04127474GO:0043149
GeneOntologyBiologicalProcesscell cycle process

ROCK2 SFPQ WRN ROCK1 CEP152 NUF2 TEX12 TRRAP ANKFN1 CIT IQGAP3

3.12e-0414414711GO:0022402
GeneOntologyBiologicalProcessestablishment of endothelial barrier

ROCK2 ROCK1 IKBKB

3.13e-0458473GO:0061028
GeneOntologyBiologicalProcesspositive regulation of connective tissue replacement

ROCK2 ROCK1

3.90e-0413472GO:1905205
GeneOntologyBiologicalProcessendothelial cell differentiation

ROCK2 ROCK1 IKBKB S1PR1

4.58e-04158474GO:0045446
GeneOntologyBiologicalProcessregulation of endothelial cell differentiation

ROCK2 ROCK1 IKBKB

4.80e-0467473GO:0045601
GeneOntologyBiologicalProcessmicrotubule-based process

ROCK2 SFPQ KIF27 SPG7 ROCK1 CEP152 NUF2 ANKFN1 DNAH9

5.55e-041058479GO:0007017
GeneOntologyBiologicalProcessregulation of actin filament organization

ROCK2 ROCK1 CGNL1 CIT S1PR1

5.86e-04300475GO:0110053
GeneOntologyBiologicalProcessregulation of phosphatase activity

ROCK2 ROCK1 IKBKB

6.42e-0474473GO:0010921
GeneOntologyBiologicalProcessnegative regulation of cellular component organization

ROCK2 ROCK1 NUF2 CGNL1 IKBKB CIT S1PR1 ANKRD27

6.76e-04864478GO:0051129
GeneOntologyBiologicalProcessregulation of connective tissue replacement

ROCK2 ROCK1

7.60e-0418472GO:1905203
GeneOntologyBiologicalProcessendothelium development

ROCK2 ROCK1 IKBKB S1PR1

7.78e-04182474GO:0003158
GeneOntologyBiologicalProcessendothelial cell development

ROCK2 ROCK1 IKBKB

8.06e-0480473GO:0001885
GeneOntologyBiologicalProcessbicellular tight junction assembly

ROCK2 ROCK1 IKBKB

8.35e-0481473GO:0070830
GeneOntologyBiologicalProcessactin filament bundle assembly

ROCK2 ROCK1 CGNL1 S1PR1

9.31e-04191474GO:0051017
GeneOntologyBiologicalProcessactin filament bundle organization

ROCK2 ROCK1 CGNL1 S1PR1

1.01e-03195474GO:0061572
GeneOntologyBiologicalProcesstight junction assembly

ROCK2 ROCK1 IKBKB

1.06e-0388473GO:0120192
GeneOntologyBiologicalProcessapical junction assembly

ROCK2 ROCK1 IKBKB

1.13e-0390473GO:0043297
GeneOntologyBiologicalProcesscytokinesis

ROCK2 ROCK1 CIT IQGAP3

1.19e-03204474GO:0000910
GeneOntologyBiologicalProcesstight junction organization

ROCK2 ROCK1 IKBKB

1.29e-0394473GO:0120193
GeneOntologyBiologicalProcessangiotensin-activated signaling pathway

ROCK2 ROCK1

1.36e-0324472GO:0038166
GeneOntologyBiologicalProcesspositive regulation of tissue remodeling

ROCK2 ROCK1

1.36e-0324472GO:0034105
GeneOntologyBiologicalProcessregulation of epithelial cell differentiation

ROCK2 SALL1 ROCK1 IKBKB

1.49e-03217474GO:0030856
GeneOntologyBiologicalProcessresponse to vitamin

TPCN2 NFKBIZ TRIM24

1.54e-03100473GO:0033273
GeneOntologyBiologicalProcessconnective tissue replacement

ROCK2 ROCK1

1.60e-0326472GO:0097709
DomainRho_Binding

ROCK2 ROCK1

6.47e-062482PF08912
DomainRho-bd_dom

ROCK2 ROCK1

6.47e-062482IPR015008
DomainROCK1/ROCK2

ROCK2 ROCK1

6.47e-062482IPR020684
DomainDUF4195

ZNF280D ZNF280C

3.87e-054482IPR025243
DomainDUF4195

ZNF280D ZNF280C

3.87e-054482PF13836
DomainPkinase_C

ROCK2 ROCK1 CIT

1.16e-0437483IPR017892
DomainPkinase_C

ROCK2 ROCK1 CIT

1.70e-0442483PF00433
DomainHR1

ROCK2 ROCK1

1.79e-048482PF02185
DomainAGC-kinase_C

ROCK2 ROCK1 CIT

4.01e-0456483IPR000961
DomainAGC_KINASE_CTER

ROCK2 ROCK1 CIT

4.01e-0456483PS51285
DomainS_TK_X

ROCK2 ROCK1 CIT

4.01e-0456483SM00133
Domain-

CTTNBP2 NFKBIZ PPP1R13L ANKFN1 ANKRD27

4.26e-042484851.25.40.20
DomainANK

CTTNBP2 NFKBIZ PPP1R13L ANKFN1 ANKRD27

4.50e-04251485SM00248
DomainANK_REPEAT

CTTNBP2 NFKBIZ PPP1R13L ANKFN1 ANKRD27

4.67e-04253485PS50088
DomainAnkyrin_rpt-contain_dom

CTTNBP2 NFKBIZ PPP1R13L ANKFN1 ANKRD27

4.75e-04254485IPR020683
DomainANK_REP_REGION

CTTNBP2 NFKBIZ PPP1R13L ANKFN1 ANKRD27

4.75e-04254485PS50297
DomainAnkyrin_rpt

CTTNBP2 NFKBIZ PPP1R13L ANKFN1 ANKRD27

5.47e-04262485IPR002110
DomainZF_DAG_PE_1

ROCK2 ROCK1 CIT

5.95e-0464483PS00479
DomainZF_DAG_PE_2

ROCK2 ROCK1 CIT

5.95e-0464483PS50081
DomainC1

ROCK2 ROCK1 CIT

6.22e-0465483SM00109
DomainPE/DAG-bd

ROCK2 ROCK1 CIT

6.51e-0466483IPR002219
DomaintRNA-bd_arm

CCDC186 CEP152

1.72e-0324482IPR010978
DomainAnk_2

CTTNBP2 NFKBIZ PPP1R13L ANKRD27

2.24e-03215484PF12796
DomainAnk

CTTNBP2 NFKBIZ PPP1R13L ANKRD27

2.76e-03228484PF00023
DomainC1_1

ROCK2 CIT

9.43e-0357482PF00130
PathwayREACTOME_RHOB_GTPASE_CYCLE

ROCK2 ROCK1 CIT IQGAP3

2.91e-0570364M41806
PathwayREACTOME_RHOC_GTPASE_CYCLE

ROCK2 ROCK1 CIT IQGAP3

3.63e-0574364M41807
PathwayKEGG_MEDICUS_PATHOGEN_ESCHERICHIA_MAP_TO_LPA_GNA12_13_RHOA_SIGNALING_PATHWAY

ROCK2 ROCK1

6.31e-055362M49031
PathwayREACTOME_RHO_GTPASES_ACTIVATE_ROCKS

ROCK2 ROCK1

6.31e-055362MM15221
PathwayWP_G13_SIGNALING

ROCK2 ROCK1 CIT

1.21e-0438363M39606
PathwayWP_G13_SIGNALING_PATHWAY

ROCK2 ROCK1 CIT

1.31e-0439363MM15898
PathwayPID_RHOA_PATHWAY

ROCK2 ROCK1 CIT

2.02e-0445363M12
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNA12_13_RHO_SIGNALING_PATHWAY

ROCK2 ROCK1

2.26e-049362M47546
PathwayREACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE

ROCK2 ROCK1

3.44e-0411362MM15046
PathwayKEGG_MEDICUS_PATHOGEN_SHIGELLA_IPAA_TO_ITGA_B_RHOGEF_RHOA_SIGNALING_PATHWAY

ROCK2 ROCK1

3.44e-0411362M47721
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNA12_13_RHO_SIGNALING_PATHWAY

ROCK2 ROCK1

4.86e-0413362M47547
PathwayKEGG_MEDICUS_REFERENCE_LPA_GNA12_13_RHOA_SIGNALING_PATHWAY

ROCK2 ROCK1

4.86e-0413362M47731
PathwayREACTOME_RHOA_GTPASE_CYCLE

ROCK2 ROCK1 CIT IQGAP3

5.43e-04149364M41805
PathwayPID_THROMBIN_PAR4_PATHWAY

ROCK2 ROCK1

6.52e-0415362M138
PathwayREACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING

ROCK2 ROCK1

6.52e-0415362MM15037
PathwayREACTOME_RHOB_GTPASE_CYCLE

ROCK2 ROCK1 IQGAP3

7.14e-0469363MM15596
PathwayWP_AIRWAY_SMOOTH_MUSCLE_CELL_CONTRACTION

ROCK2 ROCK1

7.44e-0416362M40060
PathwayREACTOME_RHOC_GTPASE_CYCLE

ROCK2 ROCK1 IQGAP3

7.44e-0470363MM15597
PathwayWP_LEPTIN_SIGNALING

ROCK2 ROCK1 IKBKB

9.46e-0476363M39491
PathwayREACTOME_RHO_GTPASES_ACTIVATE_ROCKS

ROCK2 ROCK1

1.06e-0319362M27493
PathwayREACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE

ROCK2 ROCK1

1.17e-0320362M18415
PathwayREACTOME_RHO_GTPASE_EFFECTORS

ROCK2 ROCK1 NUF2 CIT IQGAP3

1.29e-03323365M27080
PathwayKEGG_MEDICUS_REFERENCE_MICROTUBULE_RHOA_SIGNALING_PATHWAY

ROCK2 ROCK1

1.29e-0321362M47767
PathwayREACTOME_RHOBTB1_GTPASE_CYCLE

ROCK2 ROCK1

1.55e-0323362M41817
PathwayREACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING

ROCK2 ROCK1

1.69e-0324362M2243
PathwayREACTOME_RHOBTB1_GTPASE_CYCLE

ROCK2 ROCK1

1.83e-0325362MM15608
Pubmed

MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.

ROCK2 ROCK1 CIT

9.16e-08749329162624
Pubmed

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases.

ROCK2 ROCK1 IKBKB

1.46e-07849325816133
Pubmed

Investigation of the esophageal Rho-kinase expression in patients with Barrett's esophagus.

ROCK2 ROCK1

1.94e-06249223789633
Pubmed

Role of Rho-Associated Coiled-Coil Forming Kinase Isoforms in Regulation of Stiffness-Induced Myofibroblast Differentiation in Lung Fibrosis.

ROCK2 ROCK1

1.94e-06249228225294
Pubmed

ROCK 1 and 2 affect the spatial architecture of 3D spheroids derived from human corneal stromal fibroblasts in different manners.

ROCK2 ROCK1

1.94e-06249235523828
Pubmed

Remnant lipoproteins from patients with sudden cardiac death enhance coronary vasospastic activity through upregulation of Rho-kinase.

ROCK2 ROCK1

1.94e-06249215044207
Pubmed

Inhibition of Rho kinase protects against colitis in mice by attenuating intestinal epithelial barrier dysfunction via MLC and the NF-κB pathway.

ROCK2 ROCK1

1.94e-06249229115372
Pubmed

ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.

ROCK2 ROCK1

1.94e-06249218414683
Pubmed

ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice.

ROCK2 ROCK1

1.94e-06249231914704
Pubmed

Investigation of the Rho-kinase Gene Polymorphism in Primary Open-angle Glaucoma.

ROCK2 ROCK1

1.94e-06249224617500
Pubmed

Differential regulation of adhesion complex turnover by ROCK1 and ROCK2.

ROCK2 ROCK1

1.94e-06249222348083
Pubmed

[Ouabain induces Rho-dependent rock activation and membrane blebbing incultured endothelial cells].

ROCK2 ROCK1

1.94e-06249225916120
Pubmed

Sulfide induces apoptosis and Rho kinase-dependent cell blebbing in Jurkat cells.

ROCK2 ROCK1

1.94e-06249223479079
Pubmed

ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness.

ROCK2 ROCK1

1.94e-06249230771534
Pubmed

Rho-associated kinase is a therapeutic target in neuroblastoma.

ROCK2 ROCK1

1.94e-06249228739902
Pubmed

Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2.

ROCK2 ROCK1

1.94e-06249226826790
Pubmed

Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension.

ROCK2 ROCK1

1.94e-06249219590140
Pubmed

Rho-GTPase effector ROCK phosphorylates cofilin in actin-meditated cytokinesis during mouse oocyte meiosis.

ROCK2 ROCK1

1.94e-06249224429217
Pubmed

Rocks: multifunctional kinases in cell behaviour.

ROCK2 ROCK1

1.94e-06249212778124
Pubmed

ROCK inhibition prevents early mouse embryo development.

ROCK2 ROCK1

1.94e-06249224562870
Pubmed

Rho kinases regulate corneal epithelial wound healing.

ROCK2 ROCK1

1.94e-06249218495812
Pubmed

Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo.

ROCK2 ROCK1

1.94e-06249225934709
Pubmed

ROCK inhibitor Y-27632 inhibits the growth, migration, and invasion of Tca8113 and CAL-27 cells in tongue squamous cell carcinoma.

ROCK2 ROCK1

1.94e-06249226468018
Pubmed

Common variants of ROCKs and the risk of hypertension, and stroke: Two case-control studies and a follow-up study in Chinese Han population.

ROCK2 ROCK1

1.94e-06249229246448
Pubmed

ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens.

ROCK2 ROCK1

1.94e-06249228035042
Pubmed

ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice.

ROCK2 ROCK1

1.94e-06249226276827
Pubmed

ROCK1 and ROCK2 regulate epithelial polarisation and geometric cell shape.

ROCK2 ROCK1

1.94e-06249222462535
Pubmed

Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction.

ROCK2 ROCK1

1.94e-06249228679962
Pubmed

Distinct Roles For ROCK1 and ROCK2 in the Regulation of Oxldl-Mediated Endothelial Dysfunction.

ROCK2 ROCK1

1.94e-06249230165352
Pubmed

The Role of ROCK in Platelet-Monocyte Collaborative Induction of Thromboinflammation during Acute Coronary Syndrome.

ROCK2 ROCK1

1.94e-06249232877952
Pubmed

Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity.

ROCK2 ROCK1

1.94e-06249230196430
Pubmed

Toll-like receptor signaling in macrophages is regulated by extracellular substrate stiffness and Rho-associated coiled-coil kinase (ROCK1/2).

ROCK2 ROCK1

1.94e-06249229800294
Pubmed

Fasudil, an inhibitor of Rho-associated coiled-coil kinase, improves cognitive impairments induced by smoke exposure.

ROCK2 ROCK1

1.94e-06249227791202
Pubmed

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease.

ROCK2 ROCK1

1.94e-06249238199985
Pubmed

Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts.

ROCK2 ROCK1

1.94e-06249218668558
Pubmed

Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation.

ROCK2 ROCK1

1.94e-06249217167780
Pubmed

ROCK in CNS: Different Roles of Isoforms and Therapeutic Target for Neurodegenerative Disorders.

ROCK2 ROCK1

1.94e-06249227033194
Pubmed

Role of Rho-kinase in regulation of insulin action and glucose homeostasis.

ROCK2 ROCK1

1.94e-06249216098829
Pubmed

Association of Rho-kinase Gene Polymorphisms with Respiratory Distress Syndrome in Preterm Neonates.

ROCK2 ROCK1

1.94e-06249227269648
Pubmed

Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma.

ROCK2 ROCK1

1.94e-06249225755711
Pubmed

Hyperoxia increases the elastic modulus of alveolar epithelial cells through Rho kinase.

ROCK2 ROCK1

1.94e-06249224289040
Pubmed

Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth.

ROCK2 ROCK1

1.94e-06249228709411
Pubmed

ROCK1 and ROCK2 Are Down-regulated in Aggressive and Advanced Skin Melanomas - A Clinicopathological Perspective.

ROCK2 ROCK1

1.94e-06249232234882
Pubmed

Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.

ROCK2 ROCK1

1.94e-06249233278350
Pubmed

Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.

ROCK2 ROCK1

1.94e-06249215096457
Pubmed

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment.

ROCK2 ROCK1

1.94e-06249223392171
Pubmed

Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout.

ROCK2 ROCK1

1.94e-06249223250919
Pubmed

Up-regulation of Rho-associated kinase 1/2 by glucocorticoids promotes migration, invasion and metastasis of melanoma.

ROCK2 ROCK1

1.94e-06249228923399
Pubmed

Rho kinase in the regulation of cell death and survival.

ROCK2 ROCK1

1.94e-06249217347801
Pubmed

Small molecule inhibition of cytoskeletal dynamics in melanoma tumors results in altered transcriptional expression patterns of key genes involved in tumor initiation and progression.

ROCK2 ROCK1

1.94e-06249221471517
Pubmed

Ser1333 phosphorylation indicates ROCKI activation.

ROCK2 ROCK1

1.94e-06249224168723
Pubmed

Distinct distribution and localization of Rho-kinase in mouse epithelial, muscle and neural tissues.

ROCK2 ROCK1

1.94e-06249222986902
Pubmed

Dissecting the roles of ROCK isoforms in stress-induced cell detachment.

ROCK2 ROCK1

1.94e-06249223598717
Pubmed

Rho kinase inhibitors block melanoma cell migration and inhibit metastasis.

ROCK2 ROCK1

1.94e-06249225840982
Pubmed

Activation of Rho kinase isoforms in lung endothelial cells during inflammation.

ROCK2 ROCK1

1.94e-06249219201893
Pubmed

ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression.

ROCK2 ROCK1

1.94e-06249222934846
Pubmed

ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo.

ROCK2 ROCK1

1.94e-06249216098146
Pubmed

ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs.

ROCK2 ROCK1

1.94e-06249229044117
Pubmed

Functional role of Rho-kinase in ameloblast differentiation.

ROCK2 ROCK1

1.94e-06249221792909
Pubmed

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.

ROCK2 ROCK1

1.94e-06249220803696
Pubmed

Role of Rho Kinase and Fasudil on Synaptic Plasticity in Multiple Sclerosis.

ROCK2 ROCK1

1.94e-06249226481340
Pubmed

Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation.

ROCK2 ROCK1

1.94e-06249219997641
Pubmed

Inhibition of ROCK activity allows InlF-mediated invasion and increased virulence of Listeria monocytogenes.

ROCK2 ROCK1

1.94e-06249218331468
Pubmed

The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.

ROCK2 ROCK1

1.94e-06249229211497
Pubmed

The connection between the cardiac glycoside-induced senescent cell morphology and Rho/Rho kinase pathway.

ROCK2 ROCK1

1.94e-06249230369081
Pubmed

Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice.

ROCK2 ROCK1

1.94e-06249229987023
Pubmed

ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice.

ROCK2 ROCK1

1.94e-0624928772201
Pubmed

Role of Rho kinase isoforms in murine allergic airway responses.

ROCK2 ROCK1

1.94e-06249221565918
Pubmed

ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells.

ROCK2 ROCK1

1.94e-06249219131646
Pubmed

Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors.

ROCK2 ROCK1

1.94e-06249231302146
Pubmed

Role of rho-kinase gene polymorphisms and protein expressions in colorectal cancer development.

ROCK2 ROCK1

1.94e-06249223328676
Pubmed

The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer.

ROCK2 ROCK1

1.94e-06249218695890
Pubmed

Inhibitors of Rho kinase (ROCK) signaling revert the malignant phenotype of breast cancer cells in 3D context.

ROCK2 ROCK1

1.94e-06249227203208
Pubmed

Rho kinases regulate the renewal and neural differentiation of embryonic stem cells in a cell plating density-dependent manner.

ROCK2 ROCK1

1.94e-06249220169147
Pubmed

Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization.

ROCK2 ROCK1

1.94e-06249222355071
Pubmed

The ROCK isoforms differentially regulate the morphological characteristics of carcinoma cells.

ROCK2 ROCK1

1.94e-06249228650698
Pubmed

ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion.

ROCK2 ROCK1

1.94e-06249222942252
Pubmed

Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis.

ROCK2 ROCK1

1.94e-06249217681946
Pubmed

Rho-associated kinase activity is required for proper morphogenesis of the inner cell mass in the mouse blastocyst.

ROCK2 ROCK1

1.94e-06249223946538
Pubmed

Opposing signaling of ROCK1 and ROCK2 determines the switching of substrate specificity and the mode of migration of glioblastoma cells.

ROCK2 ROCK1

1.94e-06249224170433
Pubmed

Rho-associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferation.

ROCK2 ROCK1

1.94e-06249212508221
Pubmed

The Rho kinase pathway regulates mouse adult neural precursor cell migration.

ROCK2 ROCK1

1.94e-06249221732490
Pubmed

Rho kinases play an obligatory role in vertebrate embryonic organogenesis.

ROCK2 ROCK1

1.94e-06249211532918
Pubmed

Rho Kinases and Cardiac Remodeling.

ROCK2 ROCK1

1.94e-06249227251065
Pubmed

Role of ROCK2 in CD4+ cells in allergic airways responses in mice.

ROCK2 ROCK1

1.94e-06249227886408
Pubmed

ROCK2 Regulates Monocyte Migration and Cell to Cell Adhesion in Vascular Endothelial Cells.

ROCK2 ROCK1

1.94e-06249230884801
Pubmed

Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts.

ROCK2 ROCK1

1.94e-06249218695640
Pubmed

Comparative Study of ROCK1 and ROCK2 in Hippocampal Spine Formation and Synaptic Function.

ROCK2 ROCK1

1.94e-06249230826947
Pubmed

Rho-associated kinases play a role in endocardial cell differentiation and migration.

ROCK2 ROCK1

1.94e-06249215464581
Pubmed

Adjustable passive stiffness in mouse bladder: regulated by Rho kinase and elevated following partial bladder outlet obstruction.

ROCK2 ROCK1

1.94e-06249222205227
Pubmed

Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis.

ROCK2 ROCK1 CIT

4.56e-062349311086988
Pubmed

Caffeine inhibits migration in glioma cells through the ROCK-FAK pathway.

ROCK2 ROCK1

5.83e-06349225011614
Pubmed

17β-Estradiol Induces Overproliferation in Adenomyotic Human Uterine Smooth Muscle Cells of the Junctional Zone Through Hyperactivation of the Estrogen Receptor-Enhanced RhoA/ROCK Signaling Pathway.

ROCK2 ROCK1

5.83e-06349225940707
Pubmed

The Rho-ROCK pathway as a new pathological mechanism of innate immune subversion in chronic myeloid leukaemia.

ROCK2 ROCK1

5.83e-06349227513300
Pubmed

Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion.

ROCK2 ROCK1

5.83e-06349218922892
Pubmed

Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function.

ROCK2 ROCK1

5.83e-06349219106222
Pubmed

Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility.

ROCK2 ROCK1

5.83e-06349210209029
Pubmed

Role of ROCK/NF‑κB/AQP8 signaling in ethanol‑induced intestinal epithelial barrier dysfunction.

ROCK2 ROCK1

5.83e-06349232705263
Pubmed

Developmentally divergent effects of Rho-kinase inhibition on cocaine- and BDNF-induced behavioral plasticity.

ROCK2 ROCK1

5.83e-06349223327740
Pubmed

Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway.

ROCK2 ROCK1

5.83e-06349231262973
InteractionKRT38 interactions

TXLNA CCDC186 CEP152 NUF2 TRIM24 IQGAP3

3.23e-06172486int:KRT38
InteractionNDC80 interactions

ROCK2 TXLNA SFPQ CCDC18 ROCK1 CEP152 NUF2

8.51e-06312487int:NDC80
InteractionHTRA3 interactions

ROCK2 ROCK1 CIT

1.01e-0518483int:HTRA3
InteractionRBM12B interactions

TXLNA TRRAP CIT HNRNPH2

2.19e-0569484int:RBM12B
Cytoband1p22.1

DIPK1A CCDC18

5.42e-04324921p22.1
Cytoband15q21.3

ZNF280D CGNL1

6.49e-043549215q21.3
CytobandEnsembl 112 genes in cytogenetic band chr15q21

ZNF280D CEP152 CGNL1

9.11e-04177493chr15q21
Cytoband19q13.32

PPP1R13L PNMA8B

2.87e-037449219q13.32
GeneFamilyAnkyrin repeat domain containing

CTTNBP2 NFKBIZ PPP1R13L ANKFN1 ANKRD27

4.47e-05242305403
GeneFamilyProteases, serine

KLK11 TMPRSS11B

4.88e-0363302738
CoexpressionFAN_EMBRYONIC_CTX_MICROGLIA_1

CCDC18 CEP152 NUF2 CIT IQGAP3

1.05e-05155495M39041
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Proliferating-Cycling_Progenitors|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

SALL1 CCDC18 CEP152 NUF2 CIT IQGAP3

7.57e-081964965905f0e3061a6b98b7a33d64c782c3dda2cd51ef
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SFPQ CCDC18 NUF2 CIT IQGAP3

1.56e-061794956718cadcc2d3b64717ed84244ef1242d392662dc
ToppCellControl-T_cells-Cycling_NK/T_cells|Control / group, cell type (main and fine annotations)

CCDC18 CEP152 NUF2 CIT IQGAP3

1.83e-061854959766216b41ee62bbac4caa25cb98ec5627a24075
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SFPQ CCDC18 NUF2 CIT IQGAP3

1.83e-061854956aeae77a087d695b1e58c5f63265e7113aa2e343
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CCDC18 CEP152 NUF2 CIT IQGAP3

2.20e-0619249527723f4e320e49d4a3daafa2d8d3946ff79fab64
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CCDC18 CEP152 NUF2 CIT IQGAP3

2.20e-061924950a54c79dcfdeb99e3b512d42b22359618cfd17e9
ToppCellhuman_hepatoblastoma-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CCDC18 CEP152 NUF2 CIT IQGAP3

2.26e-061934954b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCellCOVID-19-T_cells-Cycling_NK/T_cells|COVID-19 / group, cell type (main and fine annotations)

CCDC18 CEP152 NUF2 CIT IQGAP3

2.37e-06195495764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CCDC18 CEP152 NUF2 CIT IQGAP3

2.37e-06195495926eb3fc5d028be936885bea0654a77db3107234
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CCDC18 CEP152 NUF2 CIT IQGAP3

2.43e-0619649573f951f7712e0aa3323676b9a4b7944d21d347c4
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

CCDC186 CCDC18 NFKBIZ ROCK1 TRIM24

2.56e-0619849576d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Proliferating-cycling_dorsal_progenitors|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

CCDC18 CEP152 NUF2 CIT IQGAP3

2.56e-06198495dada1c19a261c8e1090957cd7e37f2a43a9fe14f
ToppCell15-Airway-Mesenchymal-Mesenchyme_RSPO2+|Airway / Age, Tissue, Lineage and Cell class

CCDC18 CEP152 NUF2 CIT IQGAP3

2.62e-061994955c8b847b794b3e88722f5b841f2539a27251106c
ToppCellNon-neuronal-Dividing-IPC-IPC-div1-28|World / Primary Cells by Cluster

CCDC18 CEP152 NUF2 CIT IQGAP3

2.62e-06199495787688b68ae5d8768c0a24673ae07ab07616764a
ToppCell(00)_Basal-(2)_GFP_FOXI1|(00)_Basal / shred by cell type by condition

ROCK2 CCDC186 ANXA10 NFKBIZ ROCK1

2.62e-0619949519674e1eaeb51e4196d847cb62aa437c852951d3
ToppCellNon-neuronal-Dividing-IPC-IPC-div1|World / Primary Cells by Cluster

CCDC18 CEP152 NUF2 CIT IQGAP3

2.62e-0619949572823f26ecabcae1b514b7629cfce010c97b929a
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Proliferating|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

CCDC18 CEP152 NUF2 CIT IQGAP3

2.62e-06199495d8f904f531bfe091b7d8caaa147ea4a03d627995
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

ROCK2 CCDC186 ANXA10 NFKBIZ ROCK1

2.62e-06199495a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCellLPS-antiTNF-Unknown|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NRAP NUF2 CIT IQGAP3

1.24e-05129494739b263296c28554967362060b154f7a95e1341d
ToppCellLPS-antiTNF-Unknown-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NRAP NUF2 CIT IQGAP3

1.27e-05130494615c233c7c2600c1c2bc5cf5b1c501fc474564ef
ToppCellLPS-antiTNF-Unknown-Endothelial-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NRAP NUF2 CIT IQGAP3

1.35e-0513249402491930097b75aaeedab9e8200711b0dc610944
ToppCell(08)_Brush+PNEC-(2)_GFP_FOXI1|(08)_Brush+PNEC / shred by cell type by condition

ROCK2 CCDC186 NFKBIZ ROCK1

1.61e-05138494817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCellLPS-antiTNF-Unknown-Endothelial-Monocytes-Macrophages|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF280D CCDC18 CEP152 S1PR1

1.80e-05142494b66f9602dba30d1d4fbcc49ceb112eb5bd916ba1
ToppCellLPS-antiTNF-Epithelial_airway-Mes-Epi-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CEP152 NUF2 CIT IQGAP3

3.17e-051644944307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCellLPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CEP152 NUF2 CIT IQGAP3

3.17e-051644941d84aa5b925f502ee9c5fa39714490f613a58028
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

WRN CCDC18 NUF2 CIT

3.49e-0516849452fd65024af8683db11d931f7563cbe8eb815d1c
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_ventral_progenitors|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

SALL1 CCDC18 NUF2 CIT

3.65e-0517049473601c873b177d5d134618d8e228c51381119f7d
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SALL1 NFKBIZ CGNL1 CIT

3.73e-05171494f9ae7964a3740f559431125c17c660549798cccc
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC18 NUF2 CIT IQGAP3

4.00e-0517449472df66319f6efbd88ecf439013d97409fbf3cb52
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC18 NUF2 CIT IQGAP3

4.00e-05174494c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SALL1 NFKBIZ CGNL1 CIT

4.00e-05174494a5f2a4e3b25e6084bd7003a53da86a44f6fcf294
ToppCell(01)_Cycling_Basal_(homeostasis)|World / shred by cell type and Timepoint

CCDC18 NUF2 CIT IQGAP3

4.27e-0517749405c57578142a6662f18b294d5cc11e6efd6b0f8e
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF280D CEP152 PPP1R13L PNMA8B

4.46e-05179494ce3ca7f3a5864e62307aa744a3173f350a90df28
ToppCellLPS-IL1RA-Endothelial-Endothelial-FOXM1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CEP152 NUF2 CIT IQGAP3

4.56e-05180494334e2b1f6eb7d4ece20b1c7b02107863f913237f
ToppCellP15-Endothelial-proliferative_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CCDC18 NUF2 CIT IQGAP3

4.66e-051814940c5bc1660b8fc1e905ab4230202862de5be46ebd
ToppCellP28-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CCDC18 NUF2 CIT IQGAP3

4.66e-05181494e482fd116c00ff4d8db7be3c06b1bd1ffa2d479d
ToppCellHealthy_Control-Lymphoid-T-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

NUF2 CIT IQGAP3 PNMA8B

4.66e-05181494ac1ee313910c05b1b3cb497bae14565464919c21
ToppCellP15-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CCDC18 NUF2 CIT IQGAP3

4.66e-05181494f83565f09dd971c5cad2704a4a86bca0accd955e
ToppCellP28-Endothelial-proliferative_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CCDC18 NUF2 CIT IQGAP3

4.66e-051814942be3d44619adb25d339e7a27b500a56e07e8de01
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

CTTNBP2 APOL1 TNS1 S1PR1

4.76e-05182494ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NUF2 CIT S1PR1 IQGAP3

4.97e-05184494a0831e850bc0b585296ed350fdd075c1f730308e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC18 CEP152 NUF2 IQGAP3

5.07e-0518549430e041d6f6e310d64809e9d6d93cd30052972f3b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC18 CEP152 NUF2 IQGAP3

5.29e-051874949351fa87b69a951af85b10bf91fe9b1cce8c0517
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC18 CEP152 NUF2 IQGAP3

5.29e-05187494057569c9437219ecc396aa6e673b1178a2273837
ToppCellNS-critical-d_0-4-Lymphoid-NKT-proliferating|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CEP152 NUF2 CIT IQGAP3

5.51e-05189494d6bd46abb072b13a6b72f1ca25d19f218cceb1ff
ToppCellControl-Endothelial-Endothelial-FOXM1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CEP152 NUF2 CIT IQGAP3

5.51e-051894941e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCellfacs-Skin-Anagen-3m-Epithelial-actively_dividing_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC18 NUF2 CIT IQGAP3

5.51e-05189494bfa3ed1360991a3e32fad133017c413f8adc1eba
ToppCellfacs-Skin-Anagen-3m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC18 NUF2 CIT IQGAP3

5.51e-0518949496f10c63656e446b4bb712f012e91ae986f8c2d0
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CCDC18 CEP152 CIT IQGAP3

5.63e-05190494d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CCDC18 NUF2 CIT IQGAP3

5.74e-051914940ba5b112a82e489f5a21966f78a403a7436ce73b
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CCDC18 NUF2 CIT IQGAP3

5.86e-05192494026f3e38970bea1e6e8d76a4e2becdfb8484b2ff
ToppCellProliferating|World / shred by cell class for mouse tongue

CCDC18 NUF2 CIT IQGAP3

5.86e-05192494f081f3f957cc782294e118fcc1055f6a4264ee98
ToppCelldroplet-Skin-nan-21m-Epithelial-stem_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC18 NUF2 CIT IQGAP3

5.86e-0519249496f23d6e8604d1cb24910d3118d8171b57c93e14
ToppCellCF-Epithelial-Epithelial_cell|CF / Disease state, Lineage and Cell class

KLK11 CGNL1 PPP1R13L TMPRSS11B

5.98e-051934944e3dda27c71b7fdac90d081f0d8e9ca3a8ea7820
ToppCellCF-Epithelial|CF / Disease state, Lineage and Cell class

KLK11 CGNL1 PPP1R13L TMPRSS11B

5.98e-05193494518901c2e36a79c6189cd0d9e6d36dbd4f56a79c
ToppCelldroplet-Tongue-nan-3m-Epithelial-proliferating|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC18 NUF2 CIT IQGAP3

6.10e-051944942cac1b9c4da01faaec9a67ec06f47a7060760225
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROCK2 SFPQ CCDC186 S1PR1

6.10e-05194494e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CEP152 NUF2 CIT IQGAP3

6.10e-05194494f9070035553bc68106a9e0bdf4b507715a138aba
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CEP152 NUF2 CIT IQGAP3

6.22e-051954941a5e814e12fe37287dbfc58189e1958e2c76b5da
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC18 NUF2 CIT IQGAP3

6.35e-051964940644bd14a944b9c9759a295dfdd5e67a4775f20a
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC18 NUF2 CIT IQGAP3

6.35e-0519649420383d576708b7e4bfce3e9fe40548cce496e3cb
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CEP152 NUF2 CIT IQGAP3

6.35e-051964941d2e0b328eb822db7521b5f5724d4bd17c0bad5f
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CEP152 NUF2 CIT IQGAP3

6.35e-051964941964c5003a0cb84539850a7cfe3bbb0e23a61d2d
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CEP152 NUF2 CIT IQGAP3

6.47e-051974948b616cde333bdbc0c591035ad9e4949155866245
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CEP152 NUF2 CIT IQGAP3

6.47e-0519749484ed777cdba569200a3ef1654d8a12f17fcfb7f1
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIF27 KCNN3 TTLL10 DNAH9

6.47e-0519749474a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

KIF27 TTLL10 ANKFN1 DNAH9

6.60e-051984946d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Proliferating-Cycling_Progenitors|6_mon / Sample Type, Dataset, Time_group, and Cell type.

CCDC18 CEP152 NUF2 IQGAP3

6.73e-05199494a99516a5760f49a69b0fe45a9b2316e393252966
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

ROCK2 CCDC186 NFKBIZ ROCK1

6.73e-0519949453ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Proliferating-cycling_dorsal_progenitors|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

CCDC18 NUF2 CIT IQGAP3

6.73e-05199494ca17e8c0f5bc2c41ce28351a7418d934404e563b
ToppCellLPS_anti-TNF-Endothelial-Endothelial-FOXM1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

CCDC18 CEP152 NUF2 IQGAP3

6.73e-0519949498575fcce726589e93fbb4df1aab03e57cb56076
ToppCellLPS_IL1RA-Endothelial-Endothelial-FOXM1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CCDC18 CEP152 NUF2 IQGAP3

6.73e-05199494be2276c9a1994579ba1d2998b49bf549c1324d44
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-FOXM1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SFPQ CCDC18 NUF2 IQGAP3

6.86e-052004944cfe08878a6981bf7b3567f9e82192d8f060ddde
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Stem_cells|GW26 / Sample Type, Dataset, Time_group, and Cell type.

CCDC18 CEP152 NUF2 IQGAP3

6.86e-05200494a854e19703dc920e48304541e2b06ed013292f3e
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Proliferating|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

CCDC18 CEP152 NUF2 CIT

6.86e-05200494cea58274efbe7f9e3c3ef9fbb768ebfb917e21d9
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Stem_cells-Neuroepithelial_cell|3m / Sample Type, Dataset, Time_group, and Cell type.

CEP152 NUF2 CIT IQGAP3

6.86e-052004942938a029fa0478be561574ace91f95c4a528b2d4
ToppCellControl_saline-Endothelial-Endothelial-FOXM1|Control_saline / Treatment groups by lineage, cell group, cell type

CCDC18 CEP152 NUF2 IQGAP3

6.86e-052004949bbc7b5561151f6ff65f40b3226271def732e5d9
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CEP152 NUF2 CIT IQGAP3

6.86e-05200494af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-Cilia-bearing_cell|6m / Sample Type, Dataset, Time_group, and Cell type.

KIF27 CGNL1 TTLL10 DNAH9

6.86e-05200494177f9ad8dd8635394c575a2b30140184df0bd51e
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Stem_cells|3m / Sample Type, Dataset, Time_group, and Cell type.

CEP152 NUF2 CIT IQGAP3

6.86e-05200494cfe017b4a4d604a553d0a3df9659687f38e9a7af
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Stem_cells-Neuroepithelial_cell|GW26 / Sample Type, Dataset, Time_group, and Cell type.

CCDC18 CEP152 NUF2 IQGAP3

6.86e-05200494203b9a5de4430713da01b3331e69381db449a3a0
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Intermediate|GW26 / Sample Type, Dataset, Time_group, and Cell type.

CTTNBP2 CGNL1 VCPKMT

2.35e-0410949348f675d36fece070410eb9cfe64805f4629e290f
ToppCellmild_COVID-19-RBC|World / disease group, cell group and cell class (v2)

DIPK1A TNS1 IQGAP3

2.89e-0411749385210be67ddc31903764b7fa6d7029d9656753d3
ToppCellClub_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

KLK11 ANKFN1 IQGAP3

3.12e-041204937f85208f0455f3e634f8e7e81beea60b4ef1d2a5
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPCN2 CCDC18 NUF2

3.35e-04123493a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCellfacs-Pancreas-Exocrine-24m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLK11 NRAP ANXA10

3.94e-041304933041d20fe964d282d95c0312396f26bc93929056
ToppCellfacs-Pancreas-Exocrine-24m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLK11 NRAP ANXA10

3.94e-041304938c81853c806e9a0d562e00dc5e00a8fc569a854c
ToppCellfacs-Pancreas-Exocrine-24m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLK11 NRAP ANXA10

3.94e-041304933b6a8eaef593db73c2fad2260b9f1e15950ccb70
ToppCellLPS_only-Endothelial-Endothelial-FOXM1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NUF2 CIT IQGAP3

4.31e-041344934d8f7ddad02fe76a614771e115ebb8e04623ba85
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-9|TCGA-Brain / Sample_Type by Project: Shred V9

DIPK1A KCNN3 S1PR1

4.31e-041344932647453f44b0e0a8f27ef9bba750e99eb40efc8b
ToppCellfacs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUF2 DNAH9 IQGAP3

4.99e-041414934aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCellfacs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUF2 DNAH9 IQGAP3

4.99e-04141493e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCellCOVID-19-kidney-Technical/muscle|kidney / Disease (COVID-19 only), tissue and cell type

MGAT4D ANKFN1 DNAH9

5.75e-041484930dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCellMS-CD4-CD8_2|MS / Condition, Cell_class and T cell subcluster

TPCN2 ZNF280D PPP1R13L

5.87e-0414949308fb6be5599c5988890c851ce5ac6781c319948e
ToppCellCiliated_cells-A-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

TTLL10 ANKFN1 DNAH9

6.10e-041514939d03ce73af15ef40c592d19b36aff46bebc14c40
ToppCellPND01-03-samps-Epithelial-Epithelial-non_alveolar|PND01-03-samps / Age Group, Lineage, Cell class and subclass

KLK11 KIF27 DNAH9

6.33e-04153493fc0d2d50aa3b6b2772bbf3626c9df5c5e8d7d11e
ToppCellPND01-03-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma|PND01-03-samps / Age Group, Lineage, Cell class and subclass

KLK11 KIF27 DNAH9

6.33e-041534932482247d9c39c7b99bb45fb9153442f64fd6012f
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TTLL10 ANKFN1 DNAH9

6.46e-0415449358072ce422d09f2de602580325eaac6c4ec6c136
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TTLL10 ANKFN1 DNAH9

6.46e-041544939ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NUF2 CIT IQGAP3

6.58e-041554938e239470799426ea474a36f57e1b7e0d9365ca5f
Drughexamethylmelamine

ROCK2 OPTN ROCK1 TNS1 S1PR1

2.40e-06102485CID000002123
DrugRockout

ROCK2 ROCK1

4.35e-062482CID000644354
Drug3,3-dimethylacryloyl chloride

ROCK2 ROCK1

4.35e-062482CID000102394
DrugRS 102221

ROCK2 SALL1 ROCK1

7.02e-0618483CID003693566
Drugdiguanosine pentaphosphate

ROCK2 ROCK1

2.60e-054482CID004577574
Drugtetrahydrooxazine

ROCK2 ROCK1

4.33e-055482CID000449101
Drugbrazilein

ROCK2 ROCK1

6.49e-056482CID006453902
Druglevormeloxifene

ROCK2 ROCK1

6.49e-056482ctd:C108255
Drugthymol blue

SALL1 CIT

6.49e-056482CID000065565
DrugAC1L1CTF

ROCK2 ROCK1

6.49e-056482CID000002056
Drug6-BME

ROCK2 ROCK1

9.08e-057482CID005748218
DrugAC1L2VEC

ROCK2 ROCK1

9.08e-057482CID000129320
DrugGGTI-297

ROCK2 ROCK1

1.21e-048482CID009956145
Drugheptenoic acid

ROCK2 ROCK1

1.21e-048482CID000029373
DrugN-palmitoyl-serine

ROCK2 ROCK1

1.21e-048482CID000085997
Drugoxethazaine

ROCK2 ROCK1

1.21e-048482CID000004621
DrugSC-46275

ROCK2 ROCK1

1.21e-048482CID005311427
DrugY-26763

ROCK2 ROCK1

1.21e-048482CID000121878
Diseaseage of onset of depressive disorder, wellbeing measurement

ANXA10 ANKFN1

1.02e-0410452EFO_0007869, OBA_2040166
DiseasePrimary microcephaly

CEP152 CIT

5.15e-0422452C0431350
DiseaseAutosomal Recessive Primary Microcephaly

CEP152 CIT

5.15e-0422452C3711387
DiseaseOvarian Serous Adenocarcinoma

TRIM24 TRRAP

5.64e-0423452C1335177
DiseaseAbnormality of radial ray

SALL1 RPS10

1.17e-0333452C4228778
Diseaseserum selenium measurement

KLK11 CEP152

2.98e-0353452EFO_0005266

Protein segments in the cluster

PeptideGeneStartEntry
CLKILKNNIRFMNHM

ZNF280D

326

Q6N043
LHKEMAQRMEQANKK

CCDC186

286

Q7Z3E2
AQKAHAMSANMNKAL

CEP152

456

O94986
HKTMLQMILCNKSYQ

ANXA10

191

Q9UJ72
DDKMEHAQKLMRLQN

FTHL17

61

Q9BXU8
LNDLEKKHAMLEMNA

CIT

1121

O14578
KKHAMLEMNARSLQQ

CIT

1126

O14578
RDSHLKMLAKQEAQM

ANKRD27

191

Q96NW4
QDLLKMNINMNKHLV

VCPKMT

101

Q9H867
KMNALHMLDIKEHNG

NFKBIZ

466

Q9BYH8
MNLLRNNSCLSKMKN

IKBKB

456

O14920
MKCHQQQLQRMKENA

IP6K2

181

Q9UHH9
CKMMLSVNNFVSHQK

NRAP

36

Q86VF7
AVAAMAKDKANMQHR

HNRNPH2

341

P55795
QMMVQENKGHAVSLK

KIF27

511

Q86VH2
HNFMMDTQLTKRIKN

KCNN3

556

Q9UGI6
KMQQLNAAHQEALMK

NUF2

151

Q9BZD4
NKDHRNDIMLVKMAS

KLK11

136

Q9UBX7
MKMLQARKQHMSTQL

LRRC37B

761

Q96QE4
MLAQAKMEKAANARN

IQGAP3

251

Q86VI3
HLRNKTEKNTQEMMK

MGAT4D

51

A6NG13
NKAMHLSQLDMILDQ

CCDC18

896

Q5T9S5
DMNEHLQGQLNSMKK

CGNL1

1241

Q0VF96
AHCKKMQERMSAQLA

CTTNBP2

116

Q8WZ74
DNLARQMIMKDKNWH

APOL1

116

O14791
LDQMALQCDMTKKNR

DNAH9

4371

Q9NYC9
NQMEMEHSLILNNLK

DIPK1A

401

Q5T7M9
MLKMKLHNGSNNFRL

S1PR1

146

P21453
KGNLKQHMLTHQMRD

SALL1

1041

Q9NSC2
NFQSLAMKHMDLKQM

PPP1R13L

16

Q8WUF5
NHQLKEAMKLNNQAM

OPTN

51

Q96CV9
LRHMKALMNEKAQAA

PNMA8B

51

Q9ULN7
NKLKENMERACLMSL

WRN

381

Q14191
QQMMDHEARLLVAKA

SPG7

696

Q9UQ90
KMTQQMQNLHLCQSK

ANKFN1

71

Q8N957
ELHNQEMQKRKEMQL

SFPQ

551

P23246
ADKNVPNLHVMKAMQ

RPS10

36

P46783
KDHRMKLMQQQQEVA

TRIM24

336

O15164
ENARMMERMSLKHQN

UTP14C

286

Q5TAP6
IKAKLHQMLKNNMAS

TMPRSS11B

131

Q86T26
ADKNVPNLHVMKAMQ

RPS10P5

36

Q9NQ39
MQQNKKGDMTHELVR

TNS1

1511

Q9HBL0
KMSEKQLKQENNHLM

ROCK2

821

O75116
MVVKHQKELNDMQAQ

ROCK1

1051

Q13464
CSKVLKNNIRFMNHM

ZNF280C

321

Q8ND82
LKKRMQQIMAHCFLA

TTLL10

466

Q6ZVT0
NMLQSGLHKQHMKDL

TRRAP

791

Q9Y4A5
LQKVQLDSSHKQAMM

TPCN2

366

Q8NHX9
MMANHLVKPDNRNCK

TEX12

1

Q9BXU0
RMCELMKQQETHLKQ

TXLNA

371

P40222