Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-9 ERVK-8 ERVK-19 ERVK-25

1.39e-05371685GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-9 ERVK-8 ERVK-19 ERVK-25

1.59e-05381685GO:0070001
GeneOntologyMolecularFunctiontransporter activity

CACNA1A ATP8B3 TRPC4AP CETP ESYT1 ABCB5 SLC9B1P1 ATP13A2 SVOPL CHRNA7 SLC22A12 SLC26A8 SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A SCP2 TRPV6 CACNA1H TMCO3 GRIN3A SLC24A1 ATP2A3 CHRFAM7A SLC38A8

2.87e-05128916826GO:0005215
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1A TRPC4AP CHRNA7 SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A TRPV6 CACNA1H TMCO3 GRIN3A SLC24A1 ATP2A3

4.06e-0546516814GO:0046873
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1A TRPC4AP CHRNA7 TRPV6 CACNA1H GRIN3A SLC24A1 ATP2A3

4.25e-051511688GO:0015085
GeneOntologyMolecularFunctionsodium:sulfate symporter activity

SLC13A4 SLC13A1

7.04e-0521682GO:0015382
GeneOntologyMolecularFunctionsecondary active sulfate transmembrane transporter activity

SLC26A8 SLC13A4 SLC13A1

9.19e-05111683GO:0008271
GeneOntologyMolecularFunctionMHC class II receptor activity

HLA-DQB1 HLA-DQB2 HLA-DRB1

9.19e-05111683GO:0032395
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1A TRPC4AP CHRNA7 TRPV6 CACNA1H GRIN3A SLC24A1

1.11e-041291687GO:0005262
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1A TRPC4AP ATP13A2 CHRNA7 SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A TRPV6 CACNA1H TMCO3 GRIN3A SLC24A1 ATP2A3 CHRFAM7A

1.59e-0466416816GO:0008324
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1A TRPC4AP CHRNA7 KCNH1 SCN5A SCN8A TRPV6 CACNA1H GRIN3A SLC24A1 CHRFAM7A

1.61e-0434316811GO:0005261
GeneOntologyMolecularFunctionhistone H3K9 acetyltransferase activity

KAT2A KAT2B

2.10e-0431682GO:0043992
GeneOntologyMolecularFunctionsulfate transmembrane transporter activity

SLC26A8 SLC13A4 SLC13A1

3.02e-04161683GO:0015116
GeneOntologyMolecularFunctiontransmembrane transporter activity

CACNA1A TRPC4AP ABCB5 SLC9B1P1 ATP13A2 SVOPL CHRNA7 SLC22A12 SLC26A8 SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A TRPV6 CACNA1H TMCO3 GRIN3A SLC24A1 ATP2A3 CHRFAM7A SLC38A8

3.79e-04118016822GO:0022857
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CACNA1A TRPC4AP ATP13A2 CHRNA7 SLC26A8 SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A TRPV6 CACNA1H TMCO3 GRIN3A SLC24A1 ATP2A3 CHRFAM7A

3.89e-0479316817GO:0015075
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR2F2 IL15RA HTR1A HTR5A OR4C6 HLA-DQB1 HLA-DQB2 HLA-DRB1 DDR2 OR2C3 OR2F1 OR1L3 LEPR CHRNA7 PGR NPFFR2 OR6V1 OR51D1 HMCN2 OR4A15 SORCS3 GRIN3A CHRFAM7A OR51B2

4.17e-04135316824GO:0004888
GeneOntologyMolecularFunctiontoxic substance binding

HLA-DQB2 CHRNA7 CHRFAM7A

4.35e-04181683GO:0015643
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1A TRPC4AP CHRNA7 SLC26A8 KCNH1 SCN5A SCN8A TRPV6 CACNA1H GRIN3A SLC24A1 CHRFAM7A

5.25e-0445916812GO:0005216
GeneOntologyMolecularFunctionamine binding

AMD1 HTR1A HTR5A

6.96e-04211683GO:0043176
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1A TRPC4AP CHRNA7 SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A TRPV6 CACNA1H TMCO3 GRIN3A SLC24A1 ATP2A3

8.69e-0462716814GO:0022890
GeneOntologyMolecularFunctionamide binding

CACNA1A CLN8 HMGCL LEPR CHRNA7 FASN SCP2 PPIE CHRFAM7A

9.95e-042991689GO:0033218
GeneOntologyMolecularFunctionscaffold protein binding

CHRNA7 GRK2 SCN5A CACNA1H CHRFAM7A

1.14e-03931685GO:0097110
GeneOntologyMolecularFunctionATP hydrolysis activity

ATP8B3 ATRX CCT3 KIF1A DYNC2H1 ABCB5 ATP13A2 ATP2A3 DNAH8 SNRNP200 MOV10

1.31e-0344116811GO:0016887
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN5A SCN8A CACNA1H

1.32e-03261683GO:0005248
GeneOntologyMolecularFunctionMHC class II protein complex binding

HLA-DQB1 HLA-DQB2 HLA-DRB1

1.48e-03271683GO:0023026
GeneOntologyMolecularFunctionneurotransmitter receptor activity

HTR1A HTR5A CHRNA7 GRIN3A CHRFAM7A

1.57e-031001685GO:0030594
GeneOntologyMolecularFunctionchannel activity

CACNA1A TRPC4AP CHRNA7 SLC26A8 KCNH1 SCN5A SCN8A TRPV6 CACNA1H GRIN3A SLC24A1 CHRFAM7A

1.67e-0352516812GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1A TRPC4AP CHRNA7 SLC26A8 KCNH1 SCN5A SCN8A TRPV6 CACNA1H GRIN3A SLC24A1 CHRFAM7A

1.69e-0352616812GO:0022803
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CACNA1A TRPC4AP CHRNA7 SLC26A8 SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A TRPV6 CACNA1H TMCO3 GRIN3A SLC24A1 ATP2A3

1.90e-0375816815GO:0015318
GeneOntologyBiologicalProcessregulation of secretion

CACNA1A HTR1A HLA-DRB1 CYP19A1 ATP13A2 SYT7 PREPL LEPR CHRNA7 MYOF NF1 GRK2 OTOF KCNH1 TRPV6 CACNA1H C9orf72 CHRFAM7A WNK4 RHOT1

6.62e-0680116520GO:0051046
GeneOntologyBiologicalProcesssyncytium formation

ERVK-6 CYP19A1 ERVK-9 KCNH1 ERVK-8 ERVK-19 CACNA1H

7.33e-06891657GO:0006949
GeneOntologyBiologicalProcessregulation of secretion by cell

CACNA1A HTR1A HLA-DRB1 CYP19A1 ATP13A2 SYT7 PREPL LEPR CHRNA7 MYOF NF1 GRK2 OTOF KCNH1 TRPV6 CACNA1H C9orf72 CHRFAM7A RHOT1

7.74e-0674016519GO:1903530
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

CACNA1A HTR1A KAT2A SYT7 PREPL CHRNA7 MYOF NF1 GRK2 OTOF KCNH1 SORCS3 GRIN3A SLC24A1 CHRFAM7A RHOT1 AKAP7

2.44e-0566316517GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

CACNA1A HTR1A KAT2A SYT7 PREPL CHRNA7 MYOF NF1 GRK2 OTOF KCNH1 SORCS3 GRIN3A SLC24A1 CHRFAM7A RHOT1 AKAP7

2.49e-0566416517GO:0099177
GeneOntologyBiologicalProcessnegative regulation of centriole replication

KAT2A KAT2B BRCA1

2.73e-0581653GO:0046600
GeneOntologyBiologicalProcessregulation of neurotransmitter secretion

CACNA1A PREPL MYOF NF1 OTOF KCNH1 RHOT1

4.62e-051181657GO:0046928
GeneOntologyBiologicalProcessregulation of centriole replication

CEP76 KAT2A KAT2B BRCA1

5.15e-05261654GO:0046599
GeneOntologyBiologicalProcesscell-cell fusion

ERVK-6 ERVK-9 KCNH1 ERVK-8 ERVK-19 CACNA1H

6.21e-05851656GO:0140253
GeneOntologyBiologicalProcesssyncytium formation by plasma membrane fusion

ERVK-6 ERVK-9 KCNH1 ERVK-8 ERVK-19 CACNA1H

6.21e-05851656GO:0000768
GeneOntologyBiologicalProcesspositive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure

CHRNA7 CHRFAM7A

6.36e-0521652GO:0001988
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

CACNA1A TRPC4AP SLC9B1P1 ATP13A2 CHRNA7 SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A TRPV6 CACNA1H TMCO3 GRIN3A SLC24A1 ATP2A3 WNK4 AKAP7 PCSK9 PLCE1

6.67e-0594216520GO:0098655
GeneOntologyBiologicalProcesssignal release

CACNA1A HTR1A HLA-DRB1 CYP19A1 SYT7 PREPL LEPR CHRNA7 MYOF NF1 OTOF KCNH1 TRPV6 CHRFAM7A WNK4 RHOT1

7.31e-0565316516GO:0023061
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

CACNA1A TRPC4AP SLC9B1P1 ATP13A2 CHRNA7 SLC26A8 SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A TRPV6 CACNA1H TMCO3 GRIN3A SLC24A1 ATP2A3 CHRFAM7A WNK4 AKAP7 PCSK9 PLCE1

8.31e-05111516522GO:0034220
GeneOntologyBiologicalProcessregulation of synapse structural plasticity

FRMPD4 CHRNA7 CHRFAM7A

1.05e-04121653GO:0051823
GeneOntologyBiologicalProcessovulation cycle

MSTN CHRNA7 PGR GRK2 HAS2 CHRFAM7A

1.16e-04951656GO:0042698
GeneOntologyBiologicalProcessnegative regulation of centrosome cycle

KAT2A KAT2B BRCA1

1.36e-04131653GO:0046606
GeneOntologyBiologicalProcessnegative regulation of centrosome duplication

KAT2A KAT2B BRCA1

1.36e-04131653GO:0010826
GeneOntologyBiologicalProcessregulation of neurotransmitter transport

CACNA1A PREPL MYOF NF1 OTOF KCNH1 RHOT1

1.42e-041411657GO:0051588
GeneOntologyBiologicalProcessneuronal action potential

CHRNA7 SCN5A SCN8A CACNA1H CHRFAM7A

1.49e-04631655GO:0019228
GeneOntologyBiologicalProcessmetal ion transport

CACNA1A TRPC4AP SLC9B1P1 CHRNA7 SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A TRPV6 CACNA1H TMCO3 GRIN3A SLC24A1 ATP2A3 CHRFAM7A WNK4 AKAP7 PCSK9 PLCE1

1.50e-04100016520GO:0030001
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

CACNA1A TRPC4AP SLC9B1P1 CHRNA7 SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A TRPV6 CACNA1H TMCO3 GRIN3A SLC24A1 ATP2A3 WNK4 AKAP7 PCSK9 PLCE1

1.51e-0492216519GO:0098662
GeneOntologyBiologicalProcesssignal release from synapse

CACNA1A SYT7 PREPL MYOF NF1 OTOF KCNH1 RHOT1

1.79e-041951658GO:0099643
GeneOntologyBiologicalProcessneurotransmitter secretion

CACNA1A SYT7 PREPL MYOF NF1 OTOF KCNH1 RHOT1

1.79e-041951658GO:0007269
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

CACNA1A TRPC4AP SLC9B1P1 CHRNA7 SLC26A8 SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A TRPV6 CACNA1H TMCO3 GRIN3A SLC24A1 ATP2A3 WNK4 AKAP7 PCSK9 PLCE1

1.87e-04101716520GO:0098660
GeneOntologyBiologicalProcessbaroreceptor response to decreased systemic arterial blood pressure

CHRNA7 CHRFAM7A

1.90e-0431652GO:0001982
GeneOntologyBiologicalProcessovulation cycle process

MSTN CHRNA7 PGR GRK2 CHRFAM7A

2.14e-04681655GO:0022602
GeneOntologyBiologicalProcessneurotransmitter transport

CACNA1A CLN8 SYT7 PREPL MYOF NF1 OTOF KCNH1 RHOT1

2.47e-042591659GO:0006836
GeneOntologyBiologicalProcessmonoatomic ion transport

CACNA1A TRPC4AP HTR1A SLC9B1P1 ATP13A2 CHRNA7 SLC22A12 SLC26A8 SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A TRPV6 CACNA1H TMCO3 GRIN3A SLC24A1 ATP2A3 CHRFAM7A WNK4 AKAP7 PCSK9 PLCE1

2.48e-04137416524GO:0006811
GeneOntologyBiologicalProcessMHC class II protein complex assembly

HLA-DQB1 HLA-DQB2 HLA-DRB1

2.61e-04161653GO:0002399
GeneOntologyBiologicalProcesssulfate transmembrane transport

SLC26A8 SLC13A4 SLC13A1

2.61e-04161653GO:1902358
GeneOntologyBiologicalProcesspeptide antigen assembly with MHC class II protein complex

HLA-DQB1 HLA-DQB2 HLA-DRB1

2.61e-04161653GO:0002503
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC13A4 SLC13A1 SCN5A SCN8A CACNA1H SLC24A1 WNK4 PCSK9

2.77e-042081658GO:0035725
GeneOntologyBiologicalProcesstransmission of nerve impulse

CACNA1A CHRNA7 SCN5A SCN8A CACNA1H CHRFAM7A

2.84e-041121656GO:0019226
GeneOntologyBiologicalProcesscellular homeostasis

CACNA1A ERN1 HLA-DRB1 SLC9B1P1 RHOT2 MSTN ATP13A2 LEPR CHRNA7 SLC22A12 TTC7A GRK2 MUC17 KCNH1 SLC24A1 ATP2A3 WNK4 RHOT1 PLCE1

3.31e-0498116519GO:0019725
GeneOntologyBiologicalProcesssecretion by cell

CACNA1A HTR1A HLA-DRB1 CYP19A1 ATP13A2 SYT7 PREPL LEPR CHRNA7 MYOF NF1 GRK2 OTOF KCNH1 TRPV6 CACNA1H C9orf72 CHRFAM7A WNK4 RHOT1

3.37e-04106416520GO:0032940
GeneOntologyBiologicalProcessgeneration of ovulation cycle rhythm

CHRNA7 CHRFAM7A

3.78e-0441652GO:0060112
GeneOntologyBiologicalProcessmonoatomic cation transport

CACNA1A TRPC4AP SLC9B1P1 ATP13A2 CHRNA7 SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A TRPV6 CACNA1H TMCO3 GRIN3A SLC24A1 ATP2A3 CHRFAM7A WNK4 AKAP7 PCSK9 PLCE1

3.79e-04115716521GO:0006812
GeneOntologyBiologicalProcesssodium ion transport

SLC9B1P1 SLC13A4 SLC13A1 SCN5A SCN8A CACNA1H SLC24A1 WNK4 PCSK9

3.83e-042751659GO:0006814
GeneOntologyBiologicalProcessregulation of calcium ion-dependent exocytosis

CACNA1A SYT7 TRPV6 CACNA1H

4.56e-04451654GO:0017158
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

CACNA1A HTR1A HTR5A KAT2A SYT7 PREPL CHRNA7 MYOF NF1 GRK2 OTOF KCNH1 SORCS3 GRIN3A SLC24A1 CHRFAM7A RHOT1 AKAP7

4.87e-0493116518GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

CACNA1A HTR1A HTR5A KAT2A SYT7 PREPL CHRNA7 MYOF NF1 GRK2 OTOF KCNH1 SORCS3 GRIN3A SLC24A1 CHRFAM7A RHOT1 AKAP7

4.87e-0493116518GO:0007268
GeneOntologyBiologicalProcessregulation of amine transport

CACNA1A HTR1A SYT7 CHRNA7 GRK2 CHRFAM7A

5.12e-041251656GO:0051952
GeneOntologyBiologicalProcessgamma-aminobutyric acid secretion

CACNA1A HTR1A NF1

5.18e-04201653GO:0014051
GeneOntologyBiologicalProcesscentriole replication

CEP76 KAT2A KAT2B BRCA1

5.39e-04471654GO:0007099
GeneOntologyBiologicalProcesstrans-synaptic signaling

CACNA1A HTR1A HTR5A KAT2A SYT7 PREPL CHRNA7 MYOF NF1 GRK2 OTOF KCNH1 SORCS3 GRIN3A SLC24A1 CHRFAM7A RHOT1 AKAP7

5.39e-0493916518GO:0099537
GeneOntologyBiologicalProcesssterol metabolic process

CLN8 FMO5 CETP CYP19A1 LEPR SCP2 PCSK9

5.67e-041771657GO:0016125
GeneOntologyBiologicalProcesscalcium ion import across plasma membrane

CACNA1A TRPV6 CACNA1H SLC24A1

5.84e-04481654GO:0098703
GeneOntologyBiologicalProcesscalcium ion import into cytosol

CACNA1A TRPV6 CACNA1H SLC24A1

5.84e-04481654GO:1902656
GeneOntologyBiologicalProcessregulation of exocytosis

CACNA1A ATP13A2 SYT7 PREPL KCNH1 TRPV6 CACNA1H C9orf72

5.90e-042331658GO:0017157
GeneOntologyBiologicalProcessMHC protein complex assembly

HLA-DQB1 HLA-DQB2 HLA-DRB1

6.01e-04211653GO:0002396
GeneOntologyBiologicalProcesspeptide antigen assembly with MHC protein complex

HLA-DQB1 HLA-DQB2 HLA-DRB1

6.01e-04211653GO:0002501
GeneOntologyBiologicalProcesssensory processing

CHRNA7 CHRFAM7A

6.26e-0451652GO:0050893
GeneOntologyBiologicalProcessorganic hydroxy compound transport

HTR1A CETP CYP19A1 SYT7 CHRNA7 GRK2 SCP2 CHRFAM7A WNK4 PCSK9

6.34e-0435816510GO:0015850
GeneOntologyBiologicalProcessrhythmic process

MSTN LEPR CHRNA7 PGR KAT2B GRK2 PRKDC GRIN3A HAS2 CHRFAM7A

6.62e-0436016510GO:0048511
GeneOntologyBiologicalProcessregulation of centrosome duplication

CEP76 KAT2A KAT2B BRCA1

7.93e-04521654GO:0010824
GeneOntologyBiologicalProcessmicrotubule-based process

HTR1A ATRX KIF1A DYNC2H1 TTLL5 SLC9B1P1 RHOT2 CEP76 KAT2A CHRNA7 BICDL1 CABYR KAT2B BRCA1 NINL DNAH8 CHRFAM7A RHOT1 SON

8.28e-04105816519GO:0007017
GeneOntologyBiologicalProcessamine transport

CACNA1A HTR1A SYT7 CHRNA7 GRK2 CHRFAM7A

8.30e-041371656GO:0015837
GeneOntologyBiologicalProcesssynaptic signaling

CACNA1A HTR1A HTR5A KAT2A SYT7 PREPL CHRNA7 MYOF NF1 GRK2 OTOF KCNH1 SORCS3 GRIN3A SLC24A1 CHRFAM7A RHOT1 AKAP7

8.42e-0497616518GO:0099536
GeneOntologyBiologicalProcesscentriole assembly

CEP76 KAT2A KAT2B BRCA1

8.52e-04531654GO:0098534
GeneOntologyCellularComponentcell body

GPHN CACNA1A HTR1A HTR5A CCT3 KIF1A CYP19A1 ATP13A2 SYT7 CHRNA7 PGR S100A5 HMCN2 KCNH1 SCN8A CACNA1H GRIN3A C9orf72 SLC24A1 CHRFAM7A WNK4

2.45e-0592917121GO:0044297
GeneOntologyCellularComponentneuronal cell body

GPHN CACNA1A HTR1A HTR5A KIF1A CYP19A1 ATP13A2 SYT7 CHRNA7 PGR S100A5 HMCN2 KCNH1 SCN8A CACNA1H GRIN3A C9orf72 SLC24A1 CHRFAM7A

5.62e-0583517119GO:0043025
GeneOntologyCellularComponentspine apparatus membrane

CHRNA7 CHRFAM7A

1.99e-0431712GO:0098897
GeneOntologyCellularComponentplasma membrane raft

CHRNA7 MYOF GRK2 SCN5A CACNA1H HAS2 CHRFAM7A

2.11e-041471717GO:0044853
GeneOntologyCellularComponentpostsynaptic specialization membrane

GPHN HTR5A CHRNA7 KCNH1 SCN8A SORCS3 GRIN3A CHRFAM7A

2.56e-042011718GO:0099634
GeneOntologyCellularComponentCOPII-coated ER to Golgi transport vesicle

HLA-DQB1 HLA-DQB2 HLA-DRB1 ERGIC2 SEC24C PCSK9

2.91e-041101716GO:0030134
GeneOntologyCellularComponentMHC class II protein complex

HLA-DQB1 HLA-DQB2 HLA-DRB1

3.36e-04171713GO:0042613
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN5A SCN8A CACNA1H

3.36e-04171713GO:0001518
GeneOntologyCellularComponentpresynapse

CACNA1A CLN8 HTR1A KIF1A CYP19A1 SYT7 CHRNA7 PGR MYOF NF1 GRK2 OTOF KCNH1 SCN8A CACNA1H GRIN3A C9orf72 CHRFAM7A

3.57e-0488617118GO:0098793
GeneOntologyCellularComponentneuron to neuron synapse

GPHN FRMPD4 SYT7 CHRNA7 PRR12 GRK2 KCNH1 SCN8A SORCS3 GRIN3A C9orf72 CHRFAM7A AKAP7

3.84e-0452317113GO:0098984
GeneOntologyCellularComponentextrinsic component of external side of plasma membrane

ARSA PCSK9

3.95e-0441712GO:0031232
GeneOntologyCellularComponentsomatodendritic compartment

GPHN CACNA1A HTR1A FRMPD4 HTR5A KIF1A CYP19A1 ATP13A2 SYT7 CHRNA7 PGR S100A5 NF1 GRK2 HMCN2 KCNH1 SCN8A CACNA1H GRIN3A C9orf72 SLC24A1 CHRFAM7A

4.49e-04122817122GO:0036477
GeneOntologyCellularComponentpresynaptic membrane

CACNA1A HTR1A SYT7 CHRNA7 OTOF KCNH1 SCN8A CACNA1H CHRFAM7A

4.75e-042771719GO:0042734
GeneOntologyCellularComponentglycinergic synapse

GPHN CHRNA7 CHRFAM7A

5.53e-04201713GO:0098690
GeneOntologyCellularComponentaxolemma

CHRNA7 KCNH1 CHRFAM7A

6.42e-04211713GO:0030673
GeneOntologyCellularComponentdendrite

GPHN CACNA1A HTR1A FRMPD4 HTR5A KIF1A CYP19A1 SYT7 CHRNA7 PGR NF1 GRK2 KCNH1 SCN8A CACNA1H C9orf72 CHRFAM7A

6.93e-0485817117GO:0030425
GeneOntologyCellularComponentdendritic tree

GPHN CACNA1A HTR1A FRMPD4 HTR5A KIF1A CYP19A1 SYT7 CHRNA7 PGR NF1 GRK2 KCNH1 SCN8A CACNA1H C9orf72 CHRFAM7A

7.11e-0486017117GO:0097447
GeneOntologyCellularComponentmain axon

CHRNA7 KCNH1 SCN8A C9orf72 CHRFAM7A

8.24e-04891715GO:0044304
GeneOntologyCellularComponentsynaptic membrane

GPHN CACNA1A HTR1A HTR5A SYT7 CHRNA7 OTOF KCNH1 SCN8A SORCS3 CACNA1H GRIN3A CHRFAM7A

1.05e-0358317113GO:0097060
GeneOntologyCellularComponentMHC protein complex

HLA-DQB1 HLA-DQB2 HLA-DRB1

1.22e-03261713GO:0042611
GeneOntologyCellularComponentsodium channel complex

SCN5A SCN8A CACNA1H

1.68e-03291713GO:0034706
GeneOntologyCellularComponentER to Golgi transport vesicle membrane

HLA-DQB1 HLA-DQB2 HLA-DRB1 SEC24C

1.87e-03641714GO:0012507
GeneOntologyCellularComponentpostsynaptic membrane

GPHN CACNA1A HTR5A CHRNA7 KCNH1 SCN8A SORCS3 CACNA1H GRIN3A CHRFAM7A

1.90e-0340517110GO:0045211
GeneOntologyCellularComponentspine apparatus

CHRNA7 CHRFAM7A

2.31e-0391712GO:0097444
GeneOntologyCellularComponentlumenal side of endoplasmic reticulum membrane

HLA-DQB1 HLA-DQB2 HLA-DRB1

2.90e-03351713GO:0098553
GeneOntologyCellularComponentpostsynaptic specialization

GPHN FRMPD4 HTR5A CHRNA7 PRR12 GRK2 KCNH1 SCN8A SORCS3 GRIN3A CHRFAM7A

2.94e-0350317111GO:0099572
MousePhenoimpaired spatial working memory

CHRNA7 RTL4 CHRFAM7A SON

3.34e-06121304MP:0014370
DomainMHC_II_b_N

HLA-DQB1 HLA-DQB2 HLA-DRB1

3.54e-0581633PD000328
DomainARM-type_fold

MROH9 ZYG11A TRPC4AP DNAJC13 INTS1 HEATR1 MAP3K1 NF1 PI4KA RRP12 PRKDC HEATR3

4.41e-0533916312IPR016024
DomainMHC_II_b_N

HLA-DQB1 HLA-DQB2 HLA-DRB1

5.27e-0591633IPR000353
DomainMHC_II_beta

HLA-DQB1 HLA-DQB2 HLA-DRB1

5.27e-0591633SM00921
DomainMHC_II_beta

HLA-DQB1 HLA-DQB2 HLA-DRB1

5.27e-0591633PF00969
DomainEF_assoc_2

RHOT2 RHOT1

7.57e-0521632PF08356
DomainEF_assoc_1

RHOT2 RHOT1

7.57e-0521632PF08355
DomainMIRO_dom

RHOT2 RHOT1

7.57e-0521632IPR020860
DomainHist_acetylase_PCAF

KAT2A KAT2B

7.57e-0521632IPR016376
DomainMIRO

RHOT2 RHOT1

7.57e-0521632PS51423
DomainMt_Rho_GTPase

RHOT2 RHOT1

7.57e-0521632IPR021181
DomainEF_hand_assoc_2

RHOT2 RHOT1

7.57e-0521632IPR013567
DomainEF_hand_assoc_1

RHOT2 RHOT1

7.57e-0521632IPR013566
DomainPCAF_N

KAT2A KAT2B

7.57e-0521632IPR009464
DomainPCAF_N

KAT2A KAT2B

7.57e-0521632PF06466
DomainMHC_II_a/b_N

HLA-DQB1 HLA-DQB2 HLA-DRB1

2.21e-04141633IPR014745
Domain-

HLA-DQB1 HLA-DQB2 HLA-DRB1

2.21e-041416333.10.320.10
DomainIon_trans_dom

CACNA1A KCNH1 SCN5A SCN8A TRPV6 CACNA1H

4.94e-041141636IPR005821
DomainIon_trans

CACNA1A KCNH1 SCN5A SCN8A TRPV6 CACNA1H

4.94e-041141636PF00520
DomainFerI

MYOF OTOF

7.44e-0451632SM01202
DomainFerB

MYOF OTOF

7.44e-0451632SM01201
DomainFerlin_B-domain

MYOF OTOF

7.44e-0451632IPR012561
DomainNa/sul_symport

SLC13A4 SLC13A1

7.44e-0451632IPR001898
DomainFerlin_C

MYOF OTOF

7.44e-0451632PF16165
DomainFerlin_C

MYOF OTOF

7.44e-0451632IPR032362
DomainFerIin_dom

MYOF OTOF

7.44e-0451632IPR012968
DomainFerI

MYOF OTOF

7.44e-0451632PF08151
DomainFerB

MYOF OTOF

7.44e-0451632PF08150
DomainNa_sulph_symp

SLC13A4 SLC13A1

7.44e-0451632PF00939
Domain-

MROH9 ZYG11A DNAJC13 HEATR1 NF1 RRP12 PRKDC HEATR3

7.54e-0422216381.25.10.10
DomainG_PATCH

ERVK-6 RBM5 SON

1.02e-03231633PS50174
DomainG_patch

ERVK-6 RBM5 SON

1.02e-03231633SM00443
DomainG_patch_dom

ERVK-6 RBM5 SON

1.02e-03231633IPR000467
DomainG-patch

ERVK-6 RBM5 SON

1.02e-03231633PF01585
DomainNa_trans_cytopl

SCN5A SCN8A

1.11e-0361632PF11933
DomainNa_trans_cytopl

SCN5A SCN8A

1.11e-0361632IPR024583
DomainChannel_four-helix_dom

CACNA1A SCN5A SCN8A CACNA1H

1.54e-03571634IPR027359
Domain-

CACNA1A SCN5A SCN8A CACNA1H

1.54e-035716341.20.120.350
Domain-

ESYT1 SYT7 MYOF OTOF SNRNP200 PLCE1

1.92e-0314816362.60.40.150
DomainDHC_N1

DYNC2H1 DNAH8

2.05e-0381632PF08385
DomainDynein_heavy_dom-1

DYNC2H1 DNAH8

2.05e-0381632IPR013594
DomainARM-like

MROH9 ZYG11A DNAJC13 HEATR1 NF1 RRP12 PRKDC HEATR3

2.60e-032701638IPR011989
DomainDUF1220

NBPF4 NBPF6

2.62e-0391632SM01148
Domain5HT_rcpt

HTR1A HTR5A

2.62e-0391632IPR002231
Domain-

ATP8B3 ATP13A2 ATP2A3

2.69e-033216333.40.1110.10
Domain-

ATP8B3 ATP13A2 ATP2A3

2.69e-033216332.70.150.10
DomainC2_dom

ESYT1 SYT7 MYOF OTOF SNRNP200 PLCE1

3.20e-031641636IPR000008
DomainNa_channel_asu

SCN5A SCN8A

3.25e-03101632IPR001696
DomainNa_trans_assoc

SCN5A SCN8A

3.25e-03101632IPR010526
DomainNa_trans_assoc

SCN5A SCN8A

3.25e-03101632PF06512
Domain-

FASN SCP2

3.25e-031016323.40.47.10
DomainHydrolase_3

ATP8B3 ATP2A3

3.25e-03101632PF08282
DomainThiolase-like

FASN SCP2

3.25e-03101632IPR016039
DomainVDCCAlpha1

CACNA1A CACNA1H

3.25e-03101632IPR002077
DomainATPase_P-typ_cyto_domN

ATP8B3 ATP13A2 ATP2A3

3.48e-03351633IPR023299
DomainATPase_P-typ_P_site

ATP8B3 ATP13A2 ATP2A3

3.77e-03361633IPR018303
DomainP_typ_ATPase

ATP8B3 ATP13A2 ATP2A3

3.77e-03361633IPR001757
DomainATPASE_E1_E2

ATP8B3 ATP13A2 ATP2A3

3.77e-03361633PS00154
DomainDUF1220

NBPF4 NBPF6

3.95e-03111632PF06758
DomainNBPF_dom

NBPF4 NBPF6

3.95e-03111632IPR010630
DomainNBPF

NBPF4 NBPF6

3.95e-03111632PS51316
DomainATPase_P-typ_transduc_dom_A

ATP8B3 ATP13A2 ATP2A3

4.08e-03371633IPR008250
DomainE1-E2_ATPase

ATP8B3 ATP13A2 ATP2A3

4.08e-03371633PF00122
DomainMHC_I/II-like_Ag-recog

HLA-DQB1 HLA-DQB2 HLA-DRB1

4.40e-03381633IPR011162
DomainMIRO-like

RHOT2 RHOT1

5.54e-03131632IPR013684
DomainRoc

RHOT2 RHOT1

5.54e-03131632PF08477
Domain-

IMPDH1 HMGCL NANS

5.84e-034216333.20.20.70
DomainC2

ESYT1 SYT7 MYOF OTOF PLCE1

5.87e-031311635PF00168
DomainDynein_heavy_chain_D4_dom

DYNC2H1 DNAH8

6.43e-03141632IPR024317
DomainDynein_HC_stalk

DYNC2H1 DNAH8

6.43e-03141632IPR024743
DomainDynein_heavy_dom-2

DYNC2H1 DNAH8

6.43e-03141632IPR013602
DomainDHC_N2

DYNC2H1 DNAH8

6.43e-03141632PF08393
DomainATPase_dyneun-rel_AAA

DYNC2H1 DNAH8

6.43e-03141632IPR011704
DomainMT

DYNC2H1 DNAH8

6.43e-03141632PF12777
DomainAAA_8

DYNC2H1 DNAH8

6.43e-03141632PF12780
DomainAAA_5

DYNC2H1 DNAH8

6.43e-03141632PF07728
DomainAldolase_TIM

IMPDH1 HMGCL NANS

6.65e-03441633IPR013785
DomainC2

ESYT1 SYT7 MYOF OTOF PLCE1

7.06e-031371635SM00239
DomainDHC_fam

DYNC2H1 DNAH8

7.38e-03151632IPR026983
DomainDynein_heavy

DYNC2H1 DNAH8

7.38e-03151632PF03028
DomainPI3/4_kinase_CS

PI4KA PRKDC

7.38e-03151632IPR018936
DomainDynein_heavy_dom

DYNC2H1 DNAH8

7.38e-03151632IPR004273
DomainOlfact_rcpt

OR2F2 OR4C6 OR2C3 OR2F1 OR1L3 OR6V1 OR51D1 OR4A15 OR51B2

7.73e-033931639IPR000725
DomainC2

ESYT1 SYT7 MYOF OTOF PLCE1

8.18e-031421635PS50004
Domain-

PI4KA PRKDC

8.38e-031616321.10.1070.11
DomainPI3Kc

PI4KA PRKDC

8.38e-03161632SM00146
DomainAT_hook

PRR12 KMT2C

8.38e-03161632PF02178
DomainHEAT

HEATR1 PRKDC HEATR3

8.47e-03481633PF02985
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-16 ERVK-9 ERVK-19

8.60e-096172415063128
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PALD1 IMPDH1 ESYT1 INTS1 RHOT2 KAT2A ATP13A2 GGT7 PRR12 KMT2C MYOF FASN PI4KA TLN1 RRP12 SCN5A SCN8A NINL CACNA1H PRKDC ATP2A3 AHNAK2

3.26e-0811051722235748872
Pubmed

Activation of the cholinergic antiinflammatory pathway ameliorates obesity-induced inflammation and insulin resistance.

LEPR CHRNA7 CHRFAM7A

1.19e-073172321239433
Pubmed

Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation.

CHRNA7 CHRFAM7A AKAP7

1.19e-073172324381273
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-9 ERVK-8 ERVK-19

2.77e-0712172414557543
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

CCT3 KIF1A INTS1 HEATR1 FASN UBE2O NF1 SEC24C TLN1 RRP12 POP1 PRKDC SNRNP200 MOV10 SON

9.99e-076531721522586326
Pubmed

Molecular mechanism and cellular function of MHCII ubiquitination.

HLA-DQB1 HLA-DQB2 HLA-DRB1

1.18e-065172326085212
Pubmed

A hippocampal nicotinic acetylcholine alpha 7-containing receptor complex is linked to memory retrieval in the multiple-T-maze in C57BL/6j mice.

HTR1A CHRNA7 CHRFAM7A

1.18e-065172324837029
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

IMPDH1 ATRX KIF1A ESYT1 INTS1 UFL1 HEATR1 KAT2A SYT7 INO80D PRR12 KMT2C MYOF GTF3C2 BRCA1 PI4KA TLN1 RRP12 POP1 RBM5 PPIE MOV10 SON

1.49e-0614971722331527615
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

HMBOX1 ARID4B ATRX INTS1 HEATR1 KAT2A INO80D ZSCAN29 PRR12 KMT2C INTS14 GTF3C2 BRCA1 RRP12 POP1 RBM5 ELF4 PRKDC SNRNP200 SON HELLS

1.89e-0612941722130804502
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

DNAJC13 CCT3 ESYT1 UFL1 HEATR1 FASN UBE2O SEC24C TLN1 PYCR1 PRKDC SNRNP200 SON HELLS

3.93e-066381721433239621
Pubmed

Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.

PGR KMT2C KAT2B

6.54e-068172321447625
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-16 ERVK-9 ERVK-8 ERVK-19 ERVK-25

7.61e-0694172621542922
Pubmed

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.

CCT3 MYOF FASN TLN1 RRP12 PRKDC SNRNP200

7.96e-06144172735681168
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

DNAJC13 CCT3 MYOF FASN PI4KA RRP12 PRKDC SNRNP200

8.05e-06202172833005030
Pubmed

Human transcription factor protein interaction networks.

HMBOX1 ERCC4 ARID4B ATRX CCT3 RHOT2 KAT2A EYA3 INO80D PRR12 KMT2C KAT2B UBE2O GTF3C2 BRCA1 RRP12 GMEB1 ELF4 MOV10 RHOT1 HELLS

8.71e-0614291722135140242
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

MRI1 ESYT1 MYOF FASN GRK2 TLN1 PRKDC SNRNP200 MOV10 SON

9.14e-063441721030333137
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

TLK2 CCT3 KAT2A EYA3 INO80D PRR12 KMT2C CUTA FASN BRCA1 TLN1 GMEB1 RBM5 SCP2 PRKDC SNRNP200 HEATR3 HELLS

1.00e-0511031721834189442
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DNAJC13 CCT3 ESYT1 RHOT2 HEATR1 FASN NF1 SEC24C GTF3C2 NANS PI4KA TLN1 RRP12 POP1 PYCR1 PRKDC SNRNP200 MOV10 SON AHNAK2

1.33e-0513531722029467282
Pubmed

Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis.

LEPR CHRNA7 CHRFAM7A

1.39e-0510172335087060
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

DNAJC13 ATRX DYNC2H1 ESYT1 TTLL5 UFL1 HEATR1 ATF6B PREPL UBE2O SEC24C GTF3C2 PI4KA TLN1 RRP12 POP1 PYCR1 PPIE C9orf72 SNRNP200 HELLS

1.58e-0514871722133957083
Pubmed

A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.

LEPR CHRNA7 CHRFAM7A

1.90e-0511172335276096
Pubmed

Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.

KAT2A LEPR KAT2B

1.90e-0511172324051374
Pubmed

Differential expression of nicotinic acetylcholine receptor subunits in fetal and neonatal mouse thymus.

CHRNA7 PRKDC CHRFAM7A

1.90e-0511172312225896
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

HMBOX1 AMD1 ARID4B TTLL5 CEP76 KAT2B UBE2O GTF3C2 BRCA1 PI4KA TLN1 SCP2 HELLS

2.15e-056451721325281560
Pubmed

Specific HLA-DRB and -DQB alleles and haplotypes confer disease susceptibility or resistance in Bahraini type 1 diabetes patients.

HLA-DQB1 HLA-DRB1

2.43e-052172215013978
Pubmed

Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B.

HLA-DQB1 HLA-DRB1

2.43e-052172225009391
Pubmed

Genetic prediction of type 1 diabetes in a population with low frequency of HLA risk genotypes and low incidence of the disease (the DIABFIN study).

HLA-DQB1 HLA-DRB1

2.43e-052172215037989
Pubmed

HLA class II genes determine the natural variance of hepatitis C viral load.

HLA-DQB1 HLA-DRB1

2.43e-052172211124840
Pubmed

Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.

CHRNA7 CHRFAM7A

2.43e-052172234453977
Pubmed

Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.

CHRNA7 CHRFAM7A

2.43e-052172223521765
Pubmed

Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.

CHRNA7 CHRFAM7A

2.43e-052172228258105
Pubmed

The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.

CHRNA7 CHRFAM7A

2.43e-052172219344760
Pubmed

Human leukocyte antigen-DR15, low infant sibling exposure and multiple sclerosis: gene-environment interaction.

HLA-DQB1 HLA-DRB1

2.43e-052172220225292
Pubmed

Human Leukocyte Antigen class II polymorphisms among Croatian patients with type 1 diabetes and autoimmune polyglandular syndrome type 3 variant.

HLA-DQB1 HLA-DRB1

2.43e-052172229958949
Pubmed

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.

RHOT2 RHOT1

2.43e-052172219098100
Pubmed

Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus.

HLA-DQB1 HLA-DRB1

2.43e-052172217936227
Pubmed

Human leukocyte antigen class II alleles may contribute to the severity of hepatitis C virus-related liver disease.

HLA-DQB1 HLA-DRB1

2.43e-052172212089669
Pubmed

Ferlin Overview: From Membrane to Cancer Biology.

MYOF OTOF

2.43e-052172231443490
Pubmed

Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.

CHRNA7 CHRFAM7A

2.43e-052172229114104
Pubmed

Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais.

HLA-DQB1 HLA-DRB1

2.43e-052172212028537
Pubmed

Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.

CHRNA7 CHRFAM7A

2.43e-052172224836856
Pubmed

Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.

CHRNA7 CHRFAM7A

2.43e-052172215948184
Pubmed

Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.

CHRNA7 CHRFAM7A

2.43e-052172235678315
Pubmed

Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes.

HLA-DQB1 HLA-DRB1

2.43e-052172218356404
Pubmed

HLA-DQ association and allele competition in Chinese narcolepsy.

HLA-DQB1 HLA-DRB1

2.43e-052172222862152
Pubmed

Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins.

RHOT2 RHOT1

2.43e-052172224256248
Pubmed

Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.

CHRNA7 CHRFAM7A

2.43e-052172212628457
Pubmed

Contribution of selective HLA-DRB1/DQB1 alleles and haplotypes to the genetic susceptibility of type 1 diabetes among Lebanese and Bahraini Arabs.

HLA-DQB1 HLA-DRB1

2.43e-052172215985473
Pubmed

JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants.

HLA-DQB1 HLA-DRB1

2.43e-052172224763718
Pubmed

HLA class II haplotype DRB1*04-DQB1*0301 contributes to risk of familial generalized vitiligo and early disease onset.

HLA-DQB1 HLA-DRB1

2.43e-052172216420246
Pubmed

Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.

CHRNA7 CHRFAM7A

2.43e-052172222246862
Pubmed

The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis.

HLA-DQB1 HLA-DRB1

2.43e-052172216277691
Pubmed

Associations of HLA-DRB1 and -DQB1 alleles with severe recurrent respiratory papillomatosis in Korean patients.

HLA-DQB1 HLA-DRB1

2.43e-052172223628399
Pubmed

Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1 *01.

HLA-DQB1 HLA-DRB1

2.43e-052172215696102
Pubmed

Association of extrahepatic manifestations with HLA class II alleles and with virus genotype in HCV infected patients.

HLA-DQB1 HLA-DRB1

2.43e-052172216180280
Pubmed

Distribution of HLA-DRB1 and HLA-DQB1 families of alleles and haplotypes in Vojvodina population.

HLA-DQB1 HLA-DRB1

2.43e-052172222594481
Pubmed

High frequency of low-risk human leukocyte antigen class II genotypes in latent celiac disease.

HLA-DQB1 HLA-DRB1

2.43e-052172221075156
Pubmed

Conditional knockout of leptin receptor in the female reproductive tract reduces fertility due to parturition defects in mice.

LEPR PGR

2.43e-052172235349646
Pubmed

The association of HLA-DQB1*0602 but not HLA-DRB1*15 with obstructive sleep apnea.

HLA-DQB1 HLA-DRB1

2.43e-052172228875928
Pubmed

HLA DRB1/DQB1 alleles and DRB1-DQB1 haplotypes and the risk of rheumatoid arthritis in Tunisians: a population-based case-control study.

HLA-DQB1 HLA-DRB1

2.43e-052172227580864
Pubmed

[BRCA1 selectively regulates the expression of progesterone receptor A in sporadic invasive ductal breast carcinoma].

PGR BRCA1

2.43e-052172220646629
Pubmed

Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.

CHRNA7 CHRFAM7A

2.43e-05217221400473
Pubmed

Human leucocyte antigen alleles and haplotypes and their associations with antinuclear antibodies features in Chinese patients with primary biliary cirrhosis.

HLA-DQB1 HLA-DRB1

2.43e-052172223809616
Pubmed

Differences in idiopathic inflammatory myopathy phenotypes and genotypes between Mesoamerican Mestizos and North American Caucasians: ethnogeographic influences in the genetics and clinical expression of myositis.

HLA-DQB1 HLA-DRB1

2.43e-052172212124873
Pubmed

Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.

CHRNA7 CHRFAM7A

2.43e-052172226937017
Pubmed

HLA-DRB1 and DQB1 polymorphisms in southern France and genetic relationships with other Mediterranean populations.

HLA-DQB1 HLA-DRB1

2.43e-052172211053637
Pubmed

HLA-class II genes in Mexican Amerindian Mayas: relatedness with Guatemalan Mayans and other populations.

HLA-DQB1 HLA-DRB1

2.43e-052172220923326
Pubmed

Association of HLA-DR/DQ polymorphism with Alzheimer's disease.

HLA-DQB1 HLA-DRB1

2.43e-052172225651370
Pubmed

HLA class II is a factor in cardiovascular morbidity and mortality rates in patients with type 1 diabetes.

HLA-DQB1 HLA-DRB1

2.43e-052172222898764
Pubmed

HLA DRB1* and DQB1* allelic diversity among Nadars: a primitive south Indian Dravidian caste group.

HLA-DQB1 HLA-DRB1

2.43e-052172215336786
Pubmed

HLA in Czech adult patients with autoimmune diabetes mellitus: comparison with Czech children with type 1 diabetes and patients with type 2 diabetes.

HLA-DQB1 HLA-DRB1

2.43e-052172214675393
Pubmed

HLA DRB1* and DQB1* alleles are associated with disease severity in patients with pemphigus vulgaris.

HLA-DQB1 HLA-DRB1

2.43e-052172224602055
Pubmed

Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.

CHRNA7 CHRFAM7A

2.43e-052172216650968
Pubmed

Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.

CHRNA7 CHRFAM7A

2.43e-052172224462939
Pubmed

Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.

CHRNA7 CHRFAM7A

2.43e-052172229261717
Pubmed

HLA alleles, IFN-gamma responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis.

HLA-DQB1 HLA-DRB1

2.43e-052172215336778
Pubmed

Heat-shock protein 70-1 and HLA class II gene polymorphisms associated with celiac disease susceptibility in Navarra (Spain).

HLA-DQB1 HLA-DRB1

2.43e-052172211476906
Pubmed

Low-risk HLA genotype in Type 1 diabetes is associated with less destruction of pancreatic B-cells 12 months after diagnosis.

HLA-DQB1 HLA-DRB1

2.43e-052172217971177
Pubmed

Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.

CHRNA7 CHRFAM7A

2.43e-052172218199426
Pubmed

HIV controllers with HLA-DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responses.

HLA-DQB1 HLA-DRB1

2.43e-052172220719952
Pubmed

Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.

CHRNA7 CHRFAM7A

2.43e-052172218077004
Pubmed

Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.

CHRNA7 CHRFAM7A

2.43e-052172219462340
Pubmed

Childhood asthma and human leukocyte antigen type.

HLA-DQB1 HLA-DRB1

2.43e-052172217212706
Pubmed

NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.

CHRNA7 CHRFAM7A

2.43e-052172211790782
Pubmed

Association of HLA-DRB1 and -DQB1alleles and haplotypes with rheumatoid arthritis in a Pakistani population.

HLA-DQB1 HLA-DRB1

2.43e-052172223968403
Pubmed

Polymorphisms of the human leukocyte antigen DRB1 and DQB1 genes and the natural history of human papillomavirus infection.

HLA-DQB1 HLA-DRB1

2.43e-052172212134251
Pubmed

Acetylation of the influenza A virus polymerase subunit PA in the N-terminal domain positively regulates its endonuclease activity.

KAT2A KAT2B

2.43e-052172234270849
Pubmed

Human leukocyte antigen-DRB1*1501 and DQB1*0602 alleles are cervical cancer protective factors among Uighur and Han people in Xinjiang, China.

HLA-DQB1 HLA-DRB1

2.43e-052172225337265
Pubmed

Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only.

CHRNA7 CHRFAM7A

2.43e-052172237746145
Pubmed

The co-inheritance of type 1 diabetes and multiple sclerosis in Sardinia cannot be explained by genotype variation in the HLA region alone.

HLA-DQB1 HLA-DRB1

2.43e-052172215471889
Pubmed

A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.

CHRNA7 CHRFAM7A

2.43e-052172219631623
Pubmed

Tunisian endemic pemphigus foliaceus is associated with the HLA-DR3 gene: anti-desmoglein 1 antibody-positive healthy subjects bear protective alleles.

HLA-DQB1 HLA-DRB1

2.43e-052172219486004
Pubmed

Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.

CHRNA7 CHRFAM7A

2.43e-052172215770102
Pubmed

Association of HLA-DR/DQ polymorphism with myasthenia gravis in Tunisian patients.

HLA-DQB1 HLA-DRB1

2.43e-052172222521184
Pubmed

Estimation of genetic risk for Type 1 diabetes mellitus in newborns on dried blood spot.

HLA-DQB1 HLA-DRB1

2.43e-052172220101097
Pubmed

[Analysis of the association between HLA-DRB(1), DQB(1) gene and pulmonary tuberculosis complicated with diabetes mellitus].

HLA-DQB1 HLA-DRB1

2.43e-052172211802942
Pubmed

HLA-DQB1 0602 allele is associated with splenomegaly in Japanese sarcoidosis.

HLA-DQB1 HLA-DRB1

2.43e-052172217875181
Pubmed

High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis.

HLA-DQB1 HLA-DRB1

2.43e-052172229307888
Pubmed

Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells.

CHRNA7 CHRFAM7A

2.43e-052172220720594
Cytoband1p13.3

NBPF4 NBPF6 NBPF5P HENMT1

1.33e-046917141p13.3
GeneFamilyMiro like atypical Rho GTPases|EF-hand domain containing

RHOT2 RHOT1

3.94e-0521142392
GeneFamilyNeuroblastoma breakpoint family

NBPF4 NBPF6 NBPF5P

3.94e-04231143662
GeneFamilyFerlin family

MYOF OTOF

5.81e-0461142828
GeneFamilySodium voltage-gated channel alpha subunits

SCN5A SCN8A

1.38e-03911421203
GeneFamilyX-linked mental retardation|RNA helicases

ATRX SNRNP200

2.09e-031111421168
GeneFamilyC1-set domain containing

HLA-DQB1 HLA-DQB2 HLA-DRB1

2.34e-03421143591
GeneFamilyHistocompatibility complex|C1-set domain containing

HLA-DQB1 HLA-DQB2 HLA-DRB1

2.68e-03441143588
GeneFamilyATAC complex

KAT2A KAT2B

2.94e-031311421058
GeneFamily5-hydroxytryptamine receptors, G protein-coupled

HTR1A HTR5A

2.94e-03131142170
GeneFamilyIntegrator complex

INTS1 INTS14

3.92e-031511421366
GeneFamilyLysine acetyltransferases|ATAC complex|SAGA complex|GCN5 related N-acetyltransferases

KAT2A KAT2B

5.04e-031711421059
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

KAT2A KAT2B

5.04e-03171142486
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A ATRX KIF1A DYNC2H1 SYT7 KMT2C ATP2A3 PCSK9 SON

5.28e-0819516693e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A ATRX KIF1A DYNC2H1 SYT7 KMT2C ATP2A3 PCSK9 SON

5.28e-0819516697796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HMBOX1 ABCB5 DDR2 CHRNA7 SORCS3 GRIN3A CHRFAM7A

6.65e-061871667d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HMBOX1 ABCB5 DDR2 CHRNA7 SORCS3 GRIN3A CHRFAM7A

6.89e-061881667ee572246e0c2f41bdbc29a03edc67b831af95c09
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DYNC2H1 DDR2 MSTN MYOF PLXDC2 SORCS3 HAS2

9.35e-061971667fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCellSigmoid-(5)_Dendritic_cell-(50)_cDC2|Sigmoid / shred on region, Cell_type, and subtype

HLA-DQB1 CETP HLA-DQB2 HLA-DRB1 CYP19A1 MYOF CLUL1

9.98e-061991667402af84db90d8a49d67cf44c24766aefb00fd716
ToppCellSigmoid-Dendritic_cell-cDC2|Sigmoid / Region, Cell class and subclass

HLA-DQB1 CETP HLA-DQB2 HLA-DRB1 CYP19A1 MYOF CLUL1

9.98e-061991667cd74db6db694b68f81dcf9d9342d125d00357ec1
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DOCK4 DYNC2H1 DDR2 MYOF PLXDC2 SORCS3 HAS2

1.03e-0520016679b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12|Neuronal / cells hierarchy compared to all cells using T-Statistic

HMBOX1 ABCB5 DDR2 CHRNA7 SORCS3 GRIN3A CHRFAM7A

1.03e-052001667c74bc12e13d002dedaaf75a2244ec111e47524e1
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

HMBOX1 ABCB5 DDR2 CHRNA7 SORCS3 GRIN3A CHRFAM7A

1.03e-052001667ead9eb579bb25fde05fc15602e3d05ab6617f7ac
ToppCelldroplet-Lung-nan-3m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF1A TTLL5 GGT7 TINAG BRCA1 SLC24A1

2.29e-05152166677b319f594d5e4df29034bbf69c7490076f89dd3
Drug2,4-dinitrophenoxyamine

PALD1 CYP19A1 NPFFR2

6.83e-0661613CID000087140
DrugFenoprofen calcium salt dihydrate [53746-45-5]; Down 200; 7.2uM; MCF7; HT_HG-U133A

ERN1 LEPR MAP3K1 PHKA2 NF1 GTF3C2 CACNA1H SLC24A1 ATP2A3

9.47e-0619216193612_DN
DrugSotalol hydrochloride [959-24-0]; Up 200; 13uM; MCF7; HT_HG-U133A

DOCK4 KIF1A LEPR CABYR NF1 FBXO3 GMEB1 RBM5 AKAP7

1.12e-0519616197338_UP
DrugPalmatine chloride [3486-67-7]; Down 200; 10.4uM; MCF7; HT_HG-U133A

ZNF862 TTLL5 RHOT2 LEPR NF1 GRK2 TLN1 TRPV6 ATP2A3

1.12e-0519616192795_DN
DrugBarium

CACNA1A CHRNA7 SLC22A12 KCNH1 TRPV6 CACNA1H

1.21e-05721616ctd:D001464
DrugSulfaquinoxaline sodium salt [967-80-6]; Down 200; 12.4uM; HL60; HT_HG-U133A

CLN8 KIF1A ZNF862 TTLL5 INO80D MYOF NF1 TMCO3 PLCE1

1.21e-0519816192528_DN
Drugpropranolol

CACNA1A HTR1A HTR5A CETP HLA-DRB1 ABCB5 CHRNA7 GRK2 SCN5A TRPV6 CACNA1H ATP2A3 CHRFAM7A

1.36e-0543416113CID000004946
DiseaseC-C motif chemokine 19 measurement

DNAJC13 HLA-DQB1 HLA-DQB2 HLA-DRB1

7.41e-07141574EFO_0008047
Diseaselymphoid leukemia

AMD1 PALD1 HLA-DQB1 HLA-DQB2 ACOXL

1.74e-06381575EFO_0004289
Diseaseantibody measurement, Epstein-Barr virus infection

HLA-DQB1 HLA-DQB2 HLA-DRB1

2.92e-0661573EFO_0000769, EFO_0004556
Diseasepemphigus

HLA-DQB1 HLA-DQB2 HLA-DRB1

2.92e-0661573EFO_1000749
Diseaseubiquitin carboxyl-terminal hydrolase 25 measurement

HLA-DQB1 HLA-DQB2 HLA-DRB1 ATF6B

5.24e-06221574EFO_0021881
Diseasefeeling nervous measurement

TRPC4AP HLA-DQB1 HLA-DQB2 ATF6B NF1 SORCS3

7.30e-06871576EFO_0009597
DiseaseIgG index

HLA-DQB1 HLA-DQB2 HLA-DRB1

8.12e-0681573EFO_0006929
Diseaselung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma

DYNC2H1 HLA-DQB1 HLA-DQB2 MAP3K1 KCNH1

8.50e-06521575EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575
DiseaseEpstein Barr virus nuclear antigen 1 IgG measurement

HLA-DQB1 HLA-DQB2 HLA-DRB1

1.21e-0591573EFO_0007790
DiseaseHLA class II histocompatibility antigen, DQ alpha 2 chain measurement

HLA-DQB1 HLA-DQB2 HLA-DRB1

1.21e-0591573EFO_0801686
Diseaseseropositivity measurement

HLA-DQB1 HLA-DQB2 HLA-DRB1

1.21e-0591573EFO_0007034
DiseaseAdenoid Cystic Carcinoma

ARID4B ATRX KMT2C BRCA1 PRKDC SON

1.63e-051001576C0010606
Diseasepeptidoglycan recognition protein 1 measurement

HLA-DQB1 HLA-DQB2 HLA-DRB1

1.73e-05101573EFO_0020624
DiseaseCCL19 measurement

HLA-DQB1 HLA-DQB2 HLA-DRB1

1.73e-05101573EFO_0009415
DiseaseMHC class I polypeptide-related sequence B measurement

HLA-DQB1 HLA-DQB2 HLA-DRB1 PGBD1

1.90e-05301574EFO_0008234
DiseasecAMP-specific 3',5'-cyclic phosphodiesterase 4D measurement

HLA-DQB1 HLA-DQB2 HLA-DRB1

2.36e-05111573EFO_0020224
Diseaselatex allergy (is_implicated_in)

HLA-DQB1 HLA-DRB1

2.81e-0521572DOID:0060532 (is_implicated_in)
DiseaseGastrointestinal defect and immunodeficiency syndrome

TTC7A PI4KA

2.81e-0521572cv:C5234880
Diseasealveolar echinococcosis (is_implicated_in)

HLA-DQB1 HLA-DRB1

2.81e-0521572DOID:12148 (is_implicated_in)
DiseaseLimbic encephalitis with leucine-rich glioma-inactivated 1 antibodies

HLA-DQB1 HLA-DRB1

2.81e-0521572C4706583
Diseasemultidrug-resistant tuberculosis (is_implicated_in)

HLA-DQB1 HLA-DRB1

2.81e-0521572DOID:401 (is_implicated_in)
Diseasepure red-cell aplasia (is_implicated_in)

HLA-DQB1 HLA-DRB1

2.81e-0521572DOID:1340 (is_implicated_in)
Diseasecicatricial pemphigoid (is_implicated_in)

HLA-DQB1 HLA-DRB1

2.81e-0521572DOID:11656 (is_implicated_in)
DiseaseIntellectual Disability

TLK2 FRMPD4 HMGCL PREPL PRR12 KMT2C FASN NF1 BRCA1 SCN8A PYCR1

2.94e-0544715711C3714756
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

HLA-DQB1 CETP HLA-DQB2 PCSK9

3.16e-05341574EFO_0008317, EFO_0008596, EFO_0020944
Diseaserheumatoid arthritis, smoking status measurement, ACPA-positive rheumatoid arthritis

HLA-DQB1 HLA-DQB2 HLA-DRB1

4.06e-05131573EFO_0000685, EFO_0006527, EFO_0009459
Diseasechronic lymphocytic leukemia

HLA-DQB1 HLA-DQB2 HLA-DRB1 OR6V1 FASN ACOXL

4.36e-051191576EFO_0000095
Diseaseoligoclonal band measurement, multiple sclerosis

HLA-DQB1 HLA-DQB2 HLA-DRB1

5.15e-05141573EFO_0005206, MONDO_0005301
DiseaseNon-steroidal anti-inflammatory and antirheumatic product use measurement

HLA-DQB1 HLA-DQB2 HLA-DRB1

6.42e-05151573EFO_0009935
DiseaseChurg-Strauss syndrome

HLA-DQB1 HLA-DQB2 ACOXL

6.42e-05151573EFO_0007208
Diseasepemphigus vulgaris

HLA-DQB1 HLA-DQB2 HLA-DRB1

7.87e-05161573EFO_0004719
Diseasecathepsin L1 measurement

HLA-DRB1 PLXDC2 C9orf72

7.87e-05161573EFO_0010619
DiseaseAutistic Disorder

DOCK4 HTR5A KIF1A HLA-DRB1 CYP19A1 CHRNA7 NF1 CACNA1H

8.27e-052611578C0004352
Diseaseautoimmune polyendocrine syndrome type 2 (is_implicated_in)

HLA-DQB1 HLA-DRB1

8.41e-0531572DOID:0050168 (is_implicated_in)
Diseasecystic echinococcosis (is_implicated_in)

HLA-DQB1 HLA-DRB1

8.41e-0531572DOID:1495 (is_implicated_in)
Diseaseacute disseminated encephalomyelitis (is_implicated_in)

HLA-DQB1 HLA-DRB1

8.41e-0531572DOID:639 (is_implicated_in)
DiseaseBullous pemphigoid

HLA-DQB1 HLA-DRB1

8.41e-0531572C0030805
Diseaserheumatic heart disease (is_implicated_in)

HLA-DQB1 HLA-DRB1

8.41e-0531572DOID:0050827 (is_implicated_in)
Diseaseneuromyelitis optica (is_implicated_in)

HLA-DQB1 HLA-DRB1

8.41e-0531572DOID:8869 (is_implicated_in)
DiseaseMultiple sclerosis, susceptibility to

HLA-DQB1 HLA-DRB1

8.41e-0531572cv:C1868685
DiseaseMULTIPLE SCLEROSIS, SUSCEPTIBILITY TO

HLA-DQB1 HLA-DRB1

8.41e-0531572126200
Diseaselipoprotein measurement, phospholipid measurement

CETP HLA-DRB1 GPAM LEPR PCSK9

9.31e-05851575EFO_0004639, EFO_0004732
Diseaseresponse to interferon-beta, anti-drug antibody measurement

HLA-DQB1 HLA-DQB2 HLA-DRB1

9.51e-05171573EFO_0010559, GO_0035456
DiseaseMoyamoya Disease

HLA-DQB1 HLA-DRB1 NF1

9.51e-05171573C0026654
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

CHRNA7 MAP3K1 KMT2C BRCA1

9.70e-05451574DOID:3748 (is_implicated_in)
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

HLA-DQB1 CETP HLA-DQB2 PCSK9

1.06e-04461574EFO_0008317, EFO_0008596, EFO_0020943
Diseasehepatitis B virus infection

HLA-DQB1 HLA-DQB2 HLA-DRB1

1.35e-04191573EFO_0004197
Diseaseautoimmune polyendocrine syndrome (is_implicated_in)

HLA-DQB1 HLA-DRB1

1.68e-0441572DOID:14040 (is_implicated_in)
DiseaseOropharyngeal Carcinoma

HLA-DQB1 HLA-DRB1

1.68e-0441572C2349952
DiseaseVogt-Koyanagi-Harada disease (is_implicated_in)

HLA-DQB1 HLA-DRB1

1.68e-0441572DOID:12297 (is_implicated_in)
Diseasevulva cancer (is_implicated_in)

HLA-DQB1 HLA-DRB1

1.68e-0441572DOID:1245 (is_implicated_in)
DiseaseLiposarcoma, Pleomorphic

FASN NF1

1.68e-0441572C0205825
Diseasebacterial infectious disease (is_implicated_in)

HLA-DQB1 HLA-DRB1

1.68e-0441572DOID:104 (is_implicated_in)
Diseasemyositis (is_implicated_in)

HLA-DQB1 HLA-DRB1

1.68e-0441572DOID:633 (is_implicated_in)
Diseasehypothyroidism (is_implicated_in)

HLA-DQB1 HLA-DRB1

1.68e-0441572DOID:1459 (is_implicated_in)
DiseaseOropharyngeal Neoplasms

HLA-DQB1 HLA-DRB1

1.68e-0441572C0029295
Diseaserheumatic fever (is_implicated_in)

HLA-DQB1 HLA-DRB1

1.68e-0441572DOID:1586 (is_implicated_in)
Diseasetype 1 diabetes mellitus, latent autoimmune diabetes in adults

HLA-DQB1 HLA-DQB2

1.68e-0441572EFO_0009706, MONDO_0005147
Diseasecomplement C4 measurement

HLA-DQB1 HLA-DQB2 HLA-DRB1 ATF6B

1.71e-04521574EFO_0004984
Diseasefibrinogen measurement, coronary artery disease

DYNC2H1 HLA-DQB1 HLA-DQB2 LEPR ARSA PCSK9

1.81e-041541576EFO_0001645, EFO_0004623
DiseaseMalignant neoplasm of breast

DYNC2H1 CYP19A1 AHSA2P LEPR MAP3K1 PGR FASN NF1 BRCA1 OTOF KCNH1 POP1 SCP2 CLUL1 FASTKD3 ATP2A3

2.06e-04107415716C0006142
DiseaseHenoch-Schoenlein purpura

HLA-DQB1 HLA-DQB2 HLA-DRB1

2.11e-04221573EFO_1000965
Diseasegestational diabetes

IL15RA HLA-DQB1 HLA-DQB2

2.42e-04231573EFO_0004593
Diseaseepilepsy (implicated_via_orthology)

CACNA1A SLC13A4 SLC13A1 KCNH1 SCN5A SCN8A

2.46e-041631576DOID:1826 (implicated_via_orthology)
DiseaseBipolar Disorder

CACNA1A HTR1A HTR5A HLA-DRB1 CHRNA7 SEC24C SCN8A GRIN3A DNAH8 CHRFAM7A

2.51e-0447715710C0005586
DiseaseIGA glomerulonephritis

HLA-DQB1 HLA-DQB2 HLA-DRB1 ACOXL

2.62e-04581574EFO_0004194
Diseasephospholipids in LDL measurement

HLA-DQB1 CETP HLA-DQB2 PCSK9

2.62e-04581574EFO_0022294
Diseaselymphoma

HLA-DQB1 HLA-DQB2 HLA-DRB1

2.76e-04241573EFO_0000574
Diseasechoreatic disease (is_implicated_in)

HLA-DQB1 HLA-DRB1

2.78e-0451572DOID:12859 (is_implicated_in)
Diseasenarcolepsy-cataplexy syndrome, age at onset

HLA-DQB1 HLA-DQB2

2.78e-0451572EFO_0004847, MONDO_0016158
Diseaseatrophic gastritis (is_implicated_in)

HLA-DQB1 HLA-DRB1

2.78e-0451572DOID:8929 (is_implicated_in)
DiseaseHPV seropositivity

HLA-DQB1 HLA-DQB2

2.78e-0451572EFO_0004510
Diseaselevel of coiled-coil domain-containing protein 134 in blood serum

HLA-DQB1 HLA-DQB2

2.78e-0451572OBA_2044258
DiseaseKohlschutter-Tonz syndrome (implicated_via_orthology)

SLC13A4 SLC13A1

2.78e-0451572DOID:0111668 (implicated_via_orthology)
Diseasetyphoid fever (is_implicated_in)

HLA-DQB1 HLA-DRB1

2.78e-0451572DOID:13258 (is_implicated_in)
DiseaseVaricella zoster virus seropositivity

HLA-DQB1 HLA-DQB2

2.78e-0451572EFO_0009340
DiseaseAddison's disease (is_implicated_in)

HLA-DQB1 HLA-DRB1

2.78e-0451572DOID:13774 (is_implicated_in)
Diseaseprimary progressive multiple sclerosis (is_implicated_in)

HLA-DQB1 HLA-DRB1

2.78e-0451572DOID:0050784 (is_implicated_in)
DiseaseSchizophrenia

DOCK4 HTR1A HTR5A HLA-DQB1 HLA-DRB1 PGBD1 CHRNA7 SLC26A8 BRCA1 PI4KA ERVK-8 GRIN3A C9orf72 CHRFAM7A

2.80e-0488315714C0036341
Diseasefree cholesterol measurement, high density lipoprotein cholesterol measurement

HLA-DQB1 CETP HLA-DQB2 HLA-DRB1 GPAM LEPR OR4A15 PCSK9

2.98e-043151578EFO_0004612, EFO_0008591
Diseasetotal cholesterol measurement, high density lipoprotein cholesterol measurement

HLA-DQB1 CETP HLA-DQB2 HLA-DRB1 GPAM LEPR OR4A15 PCSK9

2.98e-043151578EFO_0004574, EFO_0004612
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

HLA-DQB1 CETP HLA-DQB2 GPAM

3.18e-04611574EFO_0008317, EFO_0008596, EFO_0020946
Diseasephospholipid measurement, high density lipoprotein cholesterol measurement

HLA-DQB1 CETP HLA-DQB2 HLA-DRB1 GPAM LEPR OR4A15 PCSK9

3.38e-043211578EFO_0004612, EFO_0004639
Diseaselysophosphatidylethanolamine 16:0 measurement

HLA-DQB1 HLA-DQB2 SORCS3

3.51e-04261573EFO_0010366
Diseasefree cholesterol measurement

CETP HLA-DRB1 GPAM LEPR PCSK9

3.54e-041131575EFO_0008591
Diseaseaspartate aminotransferase measurement

DNAJC13 HLA-DQB1 CETP HLA-DQB2 HLA-DRB1 GPAM LEPR ARSA NF1 HMCN2 BRCA1 MOV10 ACOXL PLCE1

3.54e-0490415714EFO_0004736
Diseaseserum IgE measurement

HLA-DQB1 HLA-DQB2 HLA-DRB1 TLN1

3.82e-04641574EFO_0004579
Diseaselipid measurement, high density lipoprotein cholesterol measurement

HLA-DQB1 CETP HLA-DQB2 HLA-DRB1 GPAM LEPR OR4A15 PCSK9

4.06e-043301578EFO_0004529, EFO_0004612
Diseasecognitive disorder (implicated_via_orthology)

CHRNA7 CHRFAM7A

4.16e-0461572DOID:1561 (implicated_via_orthology)
Diseaseendometriosis (is_implicated_in)

HLA-DRB1 PGR

4.16e-0461572DOID:289 (is_implicated_in)
Diseaseallergic bronchopulmonary aspergillosis (is_implicated_in)

HLA-DQB1 HLA-DRB1

4.16e-0461572DOID:13166 (is_implicated_in)
Diseaserheumatoid arthritis (biomarker_via_orthology)

CHRNA7 CHRFAM7A

4.16e-0461572DOID:7148 (biomarker_via_orthology)
Diseaseliposarcoma

FASN NF1

4.16e-0461572C0023827
DiseaseLiposarcoma, well differentiated

FASN NF1

4.16e-0461572C1370889
Diseasepneumocystosis (biomarker_via_orthology)

HLA-DQB1 HLA-DQB2

4.16e-0461572DOID:11339 (biomarker_via_orthology)
DiseaseLiposarcoma, Dedifferentiated

FASN NF1

4.16e-0461572C0205824
DiseaseEpilepsy, Generalized

CHRNA7 CACNA1H

4.16e-0461572C0014548
DiseaseAngioedema

HLA-DQB1 HLA-DRB1

4.16e-0461572C0002994
Diseaseretinal vasculature measurement

ERCC4 ANKUB1 HLA-DRB1 TTLL5 MYOF KAT2B MUC17 CLUL1 ACOXL PLCE1

4.72e-0451715710EFO_0010554
Diseasepulmonary tuberculosis

HLA-DQB1 HLA-DQB2 HLA-DRB1

4.88e-04291573EFO_1000049

Protein segments in the cluster

PeptideGeneStartEntry
PTVALHMMELFDTTV

AHSA2P

201

Q719I0
MVIAMSSIALAAEDP

CACNA1A

1251

O00555
ITAAVMLTLAEPSMS

ARID4B

1286

Q4LE39
QTPESMLLAALMIVS

ERVK-25

71

P61579
DTMIMDSIAAFLVLP

ESYT1

291

Q9BSJ8
PEVMSRLEVVFTALM

CETP

436

P11597
QTPESMLLAALMIVS

ERVK-19

71

O71037
QTPESMLLAALMIVS

ERVK-8

71

Q902F8
QTPESMLLAALMIVS

ERVK-9

71

Q9UKH3
TMDSLVDMPFATVDI

AKAP7

31

Q9P0M2
PVLAVTGMIETAAMT

ABCB5

846

Q2M3G0
MMIKTQSSLVPALTD

CUTA

121

O60888
DLSSLMVTVTEEHMP

ERGIC2

296

Q96RQ1
SDVLMVDVATSMPVV

CABYR

191

O75952
LLSVTIPMSMFILSE

ATP8B3

436

O60423
DSTTMLSISDPIHMV

CEP76

181

Q8TAP6
DGMEPTVTLLSVEMT

BICDL1

431

Q6ZP65
PTTMALSVLVTIEMC

ATP2A3

896

Q93084
SLVIGEVLSMADMAT

ACOXL

36

Q9NUZ1
MLLVAEIMPATSDSV

CHRNA7

276

P36544
EIDRMTLTMAVELPD

GRK2

401

P25098
VADSTVISSMPCLLM

C18orf25

46

Q96B23
MVVSADPLSSERAEM

NBPF4

1

Q96M43
QTPESMLLAALMIVS

HERVK_113

71

P61574
QTPESMLLAALMIVS

HERV-K104

71

P61576
QTPESMLLAALMIVS

ERVK-16

71

P61578
MLLAALMIVSTVSAG

ERVK-16

76

P61578
QTPESMLLAALMIVS

ERVK-19

71

P61572
QTPESMLLAALMIVS

ERVK-6

71

Q69383
QTPESMLLAALMIVS

ERVK-9

71

P61573
VLAITIMSPSAVMLH

NPFFR2

271

Q9Y5X5
SSLASNLPMSEEIMT

EYA3

41

Q99504
MELVNEVMLTITDPA

KAT2A

456

Q92830
MDKAFITVLEMTPVL

GPHN

326

Q9NQX3
VDAALDTVSETMTPM

PALD1

726

Q9ULE6
MASSPDMDLATVSAL

PYCR1

31

P32322
AMVEQLDTAVITPAM

HELLS

16

Q9NRZ9
ELSTGLMDSEMTPTI

KMT2C

731

Q8NEZ4
LASVEMEAMEALPVT

IL15RA

236

Q13261
EATLSMTVENIPSMP

SLC24A1

101

O60721
MVSPVELVAMESGLT

GMEB1

491

Q9Y692
ITDVLAVSMMLGITA

INTS1

541

Q8N201
MELINEVMSTITDPA

KAT2B

451

Q92831
MLDDEMTVSLSLPSD

DDR2

436

Q16832
TMSTAEVLLNMESPS

ELF4

91

Q99607
DQTDFTVTMMAPVVL

HMCN2

3856

Q8NDA2
AAVTVMLVMLSTPVA

HLA-DQB2

16

P05538
MLSSFPVVLLETMSH

HMBOX1

1

Q6NT76
MAAMETETAPLTLES

FBXO3

1

Q9UK99
AAMMLSAEPELTLAE

PCSK9

396

Q8NBP7
VLIMGPDDFIVAMVS

GGT7

476

Q9UJ14
DLVEYSSMETILPIM

RHOT1

121

Q8IXI2
DKSMTVVLTFITPML

OR4A15

296

Q8NGL6
MDLATTEVAILTVMS

OR14L1P

106

Q8NHC6
LTMLAGTDLMVTLTT

OR51B2

61

Q9Y5P1
TIDLVLSSITMPKMA

OR51D1

81

Q8NGF3
LQMMAVADITSTCPT

NEK5

666

Q6P3R8
EIITLMEDSLMVLGS

DNAH8

1446

Q96JB1
SLAVVEPSMMLLENV

FAM151B

106

Q6UXP7
MDAVVSLVTLMLDTG

PI4KA

2031

P42356
PSTDIEKIFAVAIMM

KCNH1

471

O95259
KDEMMPTTVVSLLST

LEPR

931

P48357
LMELDAAVGTLMTAI

ARSA

251

P15289
EVTIMVSSIVLLMTP

OR2F1

196

Q13607
EAAIMVSSIVLLMTP

OR2F2

196

O95006
MMEIANVSSPEVFVL

OR2C3

1

Q8N628
IESSFGMLVVMPSLD

MROH9

66

Q5TGP6
PITITESDIREMMES

RBM5

106

P52756
PSSEEISMIAEQLSM

POU2F3

306

Q9UKI9
MLLVAEIMPATSDSV

CHRFAM7A

186

Q494W8
ISSPMDTVTEADMAI

IMPDH1

66

P20839
ALIPSTMNCMEVETT

GRIN3A

411

Q8TCU5
VTMTAVPRMLSDLLV

OR6V1

71

Q8N148
LSVEFPEMMSEVIAA

PGR

901

P06401
PTTGIIISDLTMEMN

POP1

416

Q99575
STLDPSLMEMTEAAL

ALPG

301

P10696
SMVVSGLTPEEFMLV

BRCA1

1651

P38398
DTFVTEAMEVLTIMP

DYNC2H1

946

Q8NCM8
ATVTLMLAMLSTPVA

HLA-DQB1

16

P01920
FTSSMASIECVPMVI

ATP13A2

906

Q9NQ11
MTAEPMSESKLNTLV

ATRX

1

P46100
MMRSVIADSIPLSSD

HENMT1

361

Q5T8I9
DDMVTKDIMTPLVAL

HEATR3

116

Q7Z4Q2
NMLESALLSPVSSME

HEATR3

231

Q7Z4Q2
EMVIPTEDSVITEMT

DOCK4

76

Q8N1I0
LEMLIAAPDTMSVSL

CYP19A1

301

P11511
QTPESMLLAALMIVS

ERVK-25

71

P61570
QTPESMLLAALMIVS

ERVK-6

71

Q69384
PVDSMLKDMATIILS

ERN1

436

O75460
PITLLMESSDAMNLA

FRMPD4

491

Q14CM0
LKTLPSQSEMMAEIS

FMO5

396

P49326
VMDVSLSMTRPVSIE

INTS14

6

Q96SY0
TLEILMSELDPAVMD

AMD1

176

P17707
MLDPASSVEMVKVLE

HAS2

216

Q92819
CMTALTVTLMVLSSP

HLA-DRB1

11

P01911
TDLMVSVLVLPMAAL

HTR1A

81

P08908
SMAVSDVLVAALVMP

HTR5A

81

P47898
PMLIRTITMETSDDL

DNAJC13

1396

O75165
MDTMAFSLTVPTLAL

INO80D

106

Q53TQ3
DPSSMLKMVEDLISV

HEATR1

676

Q9H583
QTPESMLLAALMIVS

HERVK_113

71

Q902F9
LSMLNDIAAVPATAM

FASN

451

P49327
LSLMGITLEEIEMSA

CACNA1H

1691

O95180
IQMLLRSDVVPMTAE

PPIE

156

Q9UNP9
TPEVLLSAMREELSM

SLC22A12

316

Q96S37
MVVSDVADMFVPLLD

SEC24C

571

P53992
TSTAAMVMPIAEAVV

SLC13A1

141

Q9BZW2
TSTTAMVMPIVEAVL

SLC13A4

141

Q9UKG4
SLISSAAPTMIKMEV

SALL3

1051

Q9BXA9
LTGEVIPVMELLSSM

C9orf72

176

Q96LT7
IPVMELLSSMKSHSV

C9orf72

181

Q96LT7
LSEMSVTLLRDPSMS

KIF1A

1481

Q12756
VEAIMVLTLLSDTEM

PHKA2

1141

P46019
DIEASFPMESMLTVA

OTOF

1546

Q9HC10
EIVAMTEGLASVMAP

OR1L3

196

Q8NH93
DKAMAVSDSIITPML

OR4C6

266

Q8NH72
SMPMEISTLGTTILV

MUC17

3746

Q685J3
IAMAMSASQDALPIV

MAP3K1

1191

Q13233
MAVLEFPEMATVEIV

FREM3

1866

P0C091
ESVTDMMDNLPDLIT

RTL4

196

Q6ZR62
MSATLMVAPDSAEIS

RTL9

151

Q8NET4
ASEAMPTLLMRDTVS

RTL9

636

Q8NET4
DLVNSLTSEMLMLSP

SYT7

106

O43581
ISPLLSMEAMAFVTE

TRPC4AP

101

Q8TEL6
EEDIPTLLMAASSMD

SLC9B1P1

11

A6NJY1
MLTVTELLDVSMELG

TMCO3

511

Q6UWJ1
MVVSADPLSSERAEM

NBPF5P

1

Q86XG9
MVVSADPLSSERAEM

NBPF6

1

Q5VWK0
DLRSGSSMEAVLPIM

RHOT2

121

Q8IXI1
MEPESLVAIAGLMEV

MOV10

651

Q9HCE1
MTSEEMTASVLIPVT

PLCE1

1

Q9P212
IMLLSDPEMESSILI

SORCS3

266

Q9UPU3
SMATETSQTLIDMIP

SLC26A8

326

Q96RN1
LSFISTMETLPDTMA

FASTKD3

116

Q14CZ7
DMLSAVMQEVPLAAL

HMGCL

216

P35914
ETIITMPTESDFLMQ

MSTN

116

O14793
EMVATVSPAMIRLTG

GPAM

176

Q9HCL2
MSKITNISAVEMTPL

PLXDC2

311

Q6UX71
KLVVMDPFTDLTITM

SCN5A

711

Q14524
IPEGTILTMDMLTVK

NANS

301

Q9NR45
SIPVDISDSDMMLNI

CCT3

141

P49368
IPATLITDSMVAAAM

MRI1

221

Q9BV20
LSTRSPAEMVLETLM

RD3

16

Q7Z3Z2
VMSLSPMTEEIVTKD

PGBD1

251

Q96JS3
MLVSTALDPDMIQAL

PRR12

1856

Q9ULL5
TVTLAMALFMPDLSE

SLC38A8

356

A6NNN8
MALFMPDLSEIVSII

SLC38A8

361

A6NNN8
SAPVSIETELMMEQV

NINL

611

Q9Y2I6
AVEILAQEMMTDLPS

SCP2

251

P22307
LMTTMEAVESPESLA

RRP12

151

Q5JTH9
EAMEIMLIAVVSPVI

SVOPL

61

Q8N434
EEQSALPTLMSVMLA

TLK2

141

Q86UE8
EVTAPDVKMSLSSME

AHNAK2

786

Q8IVF2
EVTAPDVKMSLSSME

AHNAK2

1611

Q8IVF2
EVTAPDVEMSLSSME

AHNAK2

2601

Q8IVF2
EVTAPDVKMSLSSME

AHNAK2

2766

Q8IVF2
EVTAPDVKMSLSSME

AHNAK2

4086

Q8IVF2
DVMTPVVEVSLPSME

AHNAK2

4251

Q8IVF2
VTQDTMPVMESISLL

ANKUB1

91

A6NFN9
MPVMESISLLDKTVS

ANKUB1

96

A6NFN9
MAELMLLSEIADPTR

ATF6B

1

Q99941
MTTLLLEMSTPFTCV

CLN8

161

Q9UBY8
QDETMMTDLSILPSS

CLUL1

416

Q15846
STSMTMENSLILEDP

ZNF705A

101

Q6ZN79
MTEMSISREDKITTP

ZFAND5

101

O76080
MEPIVISAKTMLESA

TLN1

1596

Q9Y490
EMALLATSLPEGIMV

UBE2O

961

Q9C0C9
VMRLISASGEVVPMS

TRPV6

481

Q9H1D0
LLLTDISMENVPMDT

NF1

2461

P21359
TIELIAMDLPMVSGD

SCN8A

1826

Q9UQD0
MSLEEIMAAQPAELV

VWA5A

706

O00534
LDVLNTMMDTTLPLT

PREPL

586

Q4J6C6
TMMDTTLPLTLEELE

PREPL

591

Q4J6C6
QTPESMLLAALMIVS

ERVK-8

71

P61575
STSMTMENSLILEDP

ZNF705G

101

A8MUZ8
VMPTYDLTDSVLETM

POGLUT2

266

Q6UW63
ELSQSPMLLELMTEV

PRKDC

1751

P78527
TALVPEISSDLMANM

ZNF862

541

O60290
LSPALAAMELAQMVT

SNRNP200

1936

O75643
STSMTMENSLILEDP

ZNF705B

101

P0CI00
STSMTMENSLILEDP

ZNF705D

101

P0CH99
EEAMSELTMPSSVLK

TTC7A

686

Q9ULT0
METPLEKALTTMVTT

S100A5

1

P33763
EMTSAEASVEMSLPT

GTF3C2

41

Q8WUA4
LEDMEMALAILTTVT

TTC37

541

Q6PGP7
VVEIHVSMTPTMLAI

ERCC4

211

Q92889
EMEALMSAQVIALPS

ZSCAN29

326

Q8IWY8
LLSMNEMTASLPATT

TINAG

201

Q9UJW2
TVETIMISVISMLAD

UBE2G1

116

P62253
TFSMEVTMPAILKLV

ZYG11A

371

Q6WRX3
MLASPATETTVLMSQ

WNK4

1

Q96J92
AIESTPMILESSIMS

SON

1466

P18583
SDLMMAVDDPAAITS

UFL1

591

O94874
MPIVMARDLEETASS

TTLL5

1

Q6EMB2
MTPSELMDEIISIRV

MYOF

251

Q9NZM1