Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of fibroblast migration

AKT1 ACTR3 HAS1

2.44e-0556213GO:0010762
GeneOntologyBiologicalProcessfibroblast migration

AKT1 ACTR3 HAS1

6.34e-0577213GO:0010761
DomainArp3_met

ACTR3 ACTR3B

3.61e-063212IPR015623
DomainActin/actin-like_CS

ACTR3 ACTR3B

1.82e-0418212IPR020902
DomainACTINS_ACT_LIKE

ACTR3 ACTR3B

2.04e-0419212PS01132
DomainACTIN

ACTR3 ACTR3B

5.49e-0431212SM00268
DomainActin

ACTR3 ACTR3B

5.49e-0431212IPR004000
DomainActin

ACTR3 ACTR3B

5.49e-0431212PF00022
Domain-

LARGE2 HAS1

3.70e-03812123.90.550.10
DomainNucleotide-diphossugar_trans

LARGE2 HAS1

4.35e-0388212IPR029044
Pubmed

ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells.

ACTR3 ACTR3B

3.47e-07221210806390
Pubmed

Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival.

MAP3K11 AKT1

1.04e-06321212458207
Pubmed

Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling.

AKT1 AGT

1.04e-06321225063808
Pubmed

Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression.

AKT1 AGT

2.08e-06421217906677
Pubmed

Rac interacts with Abi-1 and WAVE2 to promote an Arp2/3-dependent actin recruitment during chlamydial invasion.

AKT1 ACTR3

3.47e-06521217501982
Pubmed

Akt negatively regulates translation of the ternary complex factor Elk-1.

MAP3K11 AKT1

3.47e-06521212944902
Pubmed

Regulation of scavenger receptor class BI gene expression by angiotensin II in vascular endothelial cells.

AKT1 AGT

3.47e-06521217404186
Pubmed

Role of Abl kinase and the Wave2 signaling complex in HIV-1 entry at a post-hemifusion step.

AKT1 ACTR3

3.47e-06521220585556
Pubmed

A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition.

AKT1 AGT

2.70e-051321218483625
Pubmed

Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development.

AKT1 AGT

3.63e-051521219782130
Pubmed

Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects.

MAP3K11 AKT1

5.28e-051821223982205
Pubmed

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

NLRP11 RHBDL2

5.90e-051921222267201
Pubmed

The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling.

AKT1 ACTR3

7.24e-052121231577955
Pubmed

Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.

MAP3K11 AKT1 AGT

1.67e-0417921318624398
Pubmed

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.

AKT1 ACTR3

3.54e-044621223793062
Pubmed

A large-scale candidate gene association study of age at menarche and age at natural menopause.

PROKR2 AKT1 AGT

5.85e-0427521320734064
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDH10 TLCD1 AGT

5.71e-051612139f02b94e29e60d50e92eaa748ebf0c36d3671bb3
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PROKR2 CKS1B AGT

7.68e-051782137975bf0a3146ee0efa4f547af5977e6bf0ba71fd
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PROKR2 TLCD1 HAS1

8.21e-051822135d8b7fe18286e27f0f50c5d2d9be56850e2cb8f4
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PROKR2 TLCD1 HAS1

8.21e-05182213904804813849b7f7f716ba1554d33b07bc0a701e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-Bergmann_glial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PROKR2 TLCD1 AGT

8.34e-0518321399bb4ceb92f6467f2359a42ab2cff6df18825a30
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-Bergmann_glial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TLCD1 AGT ACTR3B

8.34e-0518321325c96df8ea0c7bbedbb7699ee84ad6234d19cba8
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TLCD1 AGT ACTR3B

8.61e-05185213bea69058afa5aa927fe15c1f8d46460562ec4dd4
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TLCD1 AGT ACTR3B

8.61e-05185213dbbd348714cd16a4948a04648e914b1e71e2a8ef
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDH10 TLCD1 AGT

8.75e-05186213ac7a84b11b4550c4ac01eab370dc8ab88e4fb72b
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PROKR2 CKS1B AGT

9.03e-0518821395d0a796d62ce6d121e2028c378faffc14b35275
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDH10 TLCD1 AGT

9.62e-05192213d2161842a38146261847fc9061ba9322e0f087e0
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PROKR2 CKS1B AGT

9.76e-05193213f25bdd10ef531b8d8441ea84573078b4b1b0f105
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Macroglial-Astrocyte|GW23 / Sample Type, Dataset, Time_group, and Cell type.

TLCD1 AGT MGAM2

1.02e-0419621355a10faafcbe075eefdfcd7cff25ded040c23538
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PROKR2 CKS1B AGT

1.02e-0419621374093f85e095606d1c723e0d7c2d78d9cfa47c4f
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Macroglial|GW23 / Sample Type, Dataset, Time_group, and Cell type.

TLCD1 AGT MGAM2

1.02e-041962138025ec8aee8455c7b0261aa4a0caacebd2f50634
DrugR 59949

AKT1 AGT

7.32e-065202ctd:C058544
DrugAG-G-73527

AKT1 AGT

2.05e-058202CID010130417
DrugSB-C

MAP3K11 AKT1 KYAT1

2.93e-0569203CID005331010
Drugbuthionine sulfoximine

ABCC12 KYAT1 OPLAH HAS1

4.26e-05229204CID000021157
Druganthglutin

KYAT1 OPLAH

5.68e-0513202CID000125748
Drugantimycin

AKT1 AGT

6.63e-0514202ctd:C032456
Drugmethylated derivative

ETNK1 KYAT1

8.73e-0516202CID006475710
Drugphosphoramidon

AKT1 AGT

8.73e-0516202ctd:C008890
DrugN-acetylcysteine

MAP3K11 AKT1 KYAT1 AGT OPLAH

8.96e-05546205CID000000581
DrugDiatrizoate

AKT1 AGT

9.89e-0517202ctd:D003973
Drugetheno-NAD

AKT1 ACTR3 AGT

9.97e-05104203CID005288160
Drugaspirin

AKT1 ACTR3 AGT HAS1 CA6

1.03e-04563205CID000002244
DrugCL-387,785

ETNK1 AKT1

1.38e-0420202CID000002776
Drugenglitazone

AKT1 KYAT1

1.68e-0422202CID000060303
DrugDL-arginine

AKT1 AGT HAS1 CA6

2.05e-04344204CID000000232
Drugchloroacetanilide

KYAT1 HAS1

2.35e-0426202CID000011485
DrugHeparin

AKT1 ACTR3 AGT

2.40e-04140203ctd:D006493
Drugcyanidin 3-O-glucoside

AKT1 AGT

2.54e-0427202ctd:C114438
Drugsaracatinib

AKT1 AGT

2.54e-0427202CID010302451
Drugolmesartan

AKT1 AGT

2.73e-0428202ctd:C437965
Drugcalcium phosphate

RHBDL2 OPLAH HAS1

2.89e-04149203CID000024441
DrugPhosphatidic Acids

AKT1 AGT

2.93e-0429202ctd:D010712
Drug1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid

AKT1 AGT

3.58e-0432202ctd:C025603
Drugdiazomethane

KYAT1 OPLAH

4.04e-0434202CID000009550
DrugBrefeldin A

AKT1 AGT

4.29e-0435202ctd:D020126
Drugbendrofluazide

AGT CA6

5.33e-0439202CID000002315
DrugBupropion hydrochloride [31677-93-7]; Up 200; 14.4uM; HL60; HG-U133A

AKT1 KYAT1 AGT

6.52e-041972031564_UP
Drugirbesartan

AKT1 AGT

7.09e-0445202ctd:C081309
Drug3alpha, 7beta-dihydroxy-5beta-cholan-24-oic acid

HSD3B7 AKT1 KYAT1

7.43e-04206203CID000005645
DrugGlycerol

AKT1 AGT

8.41e-0449202ctd:D005990
Drugtin protoporphyrin IX

AKT1 AGT

9.11e-0451202ctd:C032628
DrugCyclic GMP

AKT1 AGT

9.11e-0451202ctd:D006152
Drugsinefungin

ACTR3 KYAT1

9.11e-0451202CID000065482
Drug4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine

AKT1 AGT

9.47e-0452202ctd:C108123
Drugindapamide

AGT CA6

9.83e-0453202CID000003702
DrugSildenafil Citrate

AKT1 AGT

9.83e-0453202ctd:D000068677
Drug3-methylquercetin

AKT1 AGT

9.83e-0453202ctd:C047368
DrugLewisite II

MAP3K11 KYAT1

1.02e-0354202CID005368106
Drugglutathione reduced

ABCC12 KYAT1 OPLAH HAS1

1.08e-03534204CID000000745
Drugtryptophan pyrolysate

KYAT1 HAS1

1.10e-0356202CID005284475
Drugendotoxin, Escherichia coli

AKT1 AGT

1.10e-0356202ctd:C044101
Diseasefocal segmental glomerulosclerosis (biomarker_via_orthology)

ACTR3 AGT

2.31e-0512182DOID:1312 (biomarker_via_orthology)
Diseaseintermediate coronary syndrome (is_marker_for)

AKT1 AGT

2.73e-0513182DOID:8805 (is_marker_for)
Diseaseimpotence (implicated_via_orthology)

AKT1 AGT

3.67e-0515182DOID:1875 (implicated_via_orthology)
Diseaseschizophrenia (is_marker_for)

AKT1 ACTR3

3.27e-0444182DOID:5419 (is_marker_for)
DiseaseCirrhosis

AKT1 AGT

4.23e-0450182C1623038
DiseaseFibrosis

AKT1 AGT

4.23e-0450182C0016059
Diseasemyocardial infarction (implicated_via_orthology)

AKT1 AGT

7.37e-0466182DOID:5844 (implicated_via_orthology)
DiseaseCardiomyopathies, Primary

AKT1 AGT

8.05e-0469182C0033141
DiseaseMyocardial Diseases, Secondary

AKT1 AGT

8.05e-0469182C0036529
DiseaseAmphetamine Abuse

PROKR2 AKT1

9.50e-0475182C0236807
DiseaseAmphetamine Addiction

PROKR2 AKT1

9.50e-0475182C0236804
DiseaseAmphetamine-Related Disorders

PROKR2 AKT1

9.50e-0475182C0236733
DiseaseCardiac Hypertrophy

AKT1 AGT

1.13e-0382182C1383860
DiseaseCardiomegaly

AKT1 AGT

1.13e-0382182C0018800
DiseaseCholestasis

HSD3B7 AGT

2.03e-03110182C0008370
DiseaseInflammation

AKT1 AGT

2.69e-03127182C0021368
Diseasehypertension (implicated_via_orthology)

AKT1 AGT

2.73e-03128182DOID:10763 (implicated_via_orthology)
DiseaseCardiomyopathies

AKT1 AGT

2.81e-03130182C0878544
DiseaseBipolar Disorder

PROKR2 AKT1 AGT

2.86e-03477183C0005586
Diseasebreast cancer (is_implicated_in)

AKT1 AGT

3.72e-03150182DOID:1612 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
EIMQHRFFAGIVWQH

AKT1

401

P31749
HGRVYVGNVAWMHVL

HSD3B7

226

Q9H2F3
QVVTHHMQRYAVWFG

ACTR3B

366

Q9P1U1
DGTVYIAQQMHFHWG

CA6

101

P23280
FRIYGMHSELWGVVH

AGT

106

P01019
HTWMVPAVRVSFYHA

LARGE2

146

Q8N3Y3
LGEHVHQQYRHNMTW

MGAM2

221

Q2M2H8
WQNMISYVVHLTAHE

NLRP11

176

P59045
WMVEGVFSQLHYTVQ

PCDH10

11

Q9P2E7
QVITHHMQRYAVWFG

ACTR3

366

P61158
RHHAWMTYEAVVSGL

HAS1

396

Q92839
VVVSAVAWAMANYIH

ETNK1

81

Q9HBU6
VNWAVQIARGMHYLH

MAP3K11

216

Q16584
WRFISYMLVHAGVQH

RHBDL2

121

Q9NX52
LMHSYTWAQHEQQVG

OPLAH

191

O14841
YQWMVYDGHQHISIA

KYAT1

216

Q16773
IGQHVYQWVYTASMV

ABCC12

846

Q96J65
LGVQQSQGWVHYMIH

CKS1B

46

P61024
IIEVGRMHMQWVSHY

RNF148

176

Q8N7C7
MDYYVVRQLSWEHGH

PROKR2

111

Q8NFJ6
GQTRASWEYLVHHVM

TLCD1

106

Q96CP7