Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
HumanPhenoInfertility

SPAG1 DNAAF4 CFAP44 WDPCP MAP3K1 DNAH1

1.86e-05314116HP:0000789
HumanPhenoMale infertility

SPAG1 DNAAF4 CFAP44 MAP3K1 DNAH1

4.18e-05209115HP:0003251
HumanPhenoDecreased fertility in females

SPAG1 DNAAF4 MAP3K1 DNAH1

4.85e-05104114HP:0000868
HumanPhenoDecreased fertility

SPAG1 DNAAF4 CFAP44 WDPCP MAP3K1 DNAH1

5.55e-05380116HP:0000144
HumanPhenoRhinitis

SPAG1 DNAAF4 WDPCP DNAH1

6.72e-05113114HP:0012384
HumanPhenoDecreased fertility in males

SPAG1 DNAAF4 CFAP44 MAP3K1 DNAH1

7.52e-05236115HP:0012041
HumanPhenoPeribronchovascular interstitial thickening

SPAG1 DNAAF4 DNAH1

1.31e-0449113HP:0025177
HumanPhenoPulmonary situs ambiguus

SPAG1 DNAAF4 DNAH1

1.31e-0449113HP:0011617
HumanPhenoAbnormal pulmonary situs morphology

SPAG1 DNAAF4 DNAH1

1.31e-0449113HP:0011615
HumanPhenoLithoptysis

SPAG1 DNAAF4 DNAH1

1.31e-0449113HP:0032543
HumanPhenoEctopic pregnancy

SPAG1 DNAAF4 DNAH1

1.31e-0449113HP:0031456
HumanPhenoAtrial situs ambiguous

SPAG1 DNAAF4 DNAH1

1.39e-0450113HP:0011539
HumanPhenoAbnormal inferior vena cava morphology

SPAG1 DNAAF4 DNAH1

1.65e-0453113HP:0025576
HumanPhenoAbnormal atrial arrangement

SPAG1 DNAAF4 DNAH1

1.75e-0454113HP:0011535
HumanPhenoNasal congestion

SPAG1 DNAAF4 DNAH1

2.40e-0460113HP:0001742
HumanPhenoRecurrent mycobacterial infections

SPAG1 DNAAF4 DNAH1

2.64e-0462113HP:0011274
HumanPhenoWheezing

SPAG1 DNAAF4 DNAH1

2.91e-0464113HP:0030828
HumanPhenoPolysplenia

SPAG1 DNAAF4 DNAH1

3.18e-0466113HP:0001748
HumanPhenoRecurrent upper and lower respiratory tract infections

SPAG1 DNAAF4 DNAH1

3.48e-0468113HP:0002873
HumanPhenoRecurrent sinopulmonary infections

SPAG1 DNAAF4 DNAH1

3.48e-0468113HP:0005425
HumanPhenoProductive cough

SPAG1 DNAAF4 DNAH1

3.48e-0468113HP:0031245
HumanPhenoChronic sinusitis

SPAG1 DNAAF4 DNAH1

3.63e-0469113HP:0011109
HumanPhenoChronic rhinitis

SPAG1 DNAAF4 DNAH1

4.29e-0473113HP:0002257
HumanPhenoNasal polyposis

SPAG1 DNAAF4 DNAH1

4.47e-0474113HP:0100582
HumanPhenoAtelectasis

SPAG1 DNAAF4 DNAH1

5.62e-0480113HP:0100750
HumanPhenoAbnormal nasal mucosa morphology

SPAG1 DNAAF4 DNAH1

5.62e-0480113HP:0000433
HumanPhenoOtitis media

SETD2 SPAG1 DNAAF4 WDPCP DNAH1

5.77e-04363115HP:0000388
HumanPhenoPersistent left superior vena cava

SPAG1 DNAAF4 DNAH1

6.26e-0483113HP:0005301
HumanPhenoAnomalous pulmonary venous return

SPAG1 DNAAF4 DNAH1

6.26e-0483113HP:0010772
HumanPhenoFemale infertility

SPAG1 DNAAF4 DNAH1

6.49e-0484113HP:0008222
HumanPhenoAbnormal superior vena cava morphology

SPAG1 DNAAF4 DNAH1

6.72e-0485113HP:0025575
HumanPhenoTransposition of the great arteries

SPAG1 DNAAF4 DNAH1

6.72e-0485113HP:0001669
HumanPhenoAbnormal vena cava morphology

SPAG1 DNAAF4 DNAH1

7.44e-0488113HP:0030971
HumanPhenoAbnormal vena cava morphology

SPAG1 DNAAF4 DNAH1

7.69e-0489113HP:0005345
HumanPhenoAbnormal pulmonary vein morphology

SPAG1 DNAAF4 DNAH1

7.69e-0489113HP:0030968
HumanPhenoAbnormality of the pulmonary veins

SPAG1 DNAAF4 DNAH1

7.69e-0489113HP:0011718
HumanPhenoAbnormal middle ear morphology

SETD2 SPAG1 DNAAF4 WDPCP DNAH1

8.04e-04390115HP:0008609
HumanPhenoAsplenia

SPAG1 DNAAF4 DNAH1

8.20e-0491113HP:0001746
HumanPhenoDouble outlet right ventricle

SPAG1 DNAAF4 DNAH1

9.02e-0494113HP:0001719
HumanPhenoCongenital malformation of the right heart

SPAG1 DNAAF4 DNAH1

9.59e-0496113HP:0011723
HumanPhenoRecurrent otitis media

SETD2 SPAG1 DNAAF4 DNAH1

9.89e-04227114HP:0000403
HumanPhenoAplasia/Hypoplasia of the spleen

SPAG1 DNAAF4 DNAH1

1.02e-0398113HP:0010451
HumanPhenoSupernumerary spleens

SPAG1 DNAAF4 DNAH1

1.11e-03101113HP:0009799
HumanPhenoPolycystic ovaries

SETD2 WDPCP MAP3K1

1.28e-03106113HP:0000147
HumanPhenoChronic bronchitis

SPAG1 DNAAF4

1.44e-0327112HP:0004469
HumanPhenoAbsent sperm flagella

CFAP44 DNAH1

1.55e-0328112HP:0032558
HumanPhenoAbnormal sperm motility

SPAG1 DNAAF4 DNAH1

1.62e-03115113HP:0012206
HumanPhenoAbnormal sperm physiology

SPAG1 DNAAF4 DNAH1

1.62e-03115113HP:0034809
HumanPhenoOvarian cystic abnormality

SETD2 WDPCP MAP3K1

1.79e-03119113HP:0000146
HumanPhenoOvarian cyst

SETD2 WDPCP MAP3K1

1.79e-03119113HP:0000138
HumanPhenoCiliary dyskinesia

SPAG1 DNAAF4

2.03e-0332112HP:0012265
HumanPhenoCoiled sperm flagella

CFAP44 DNAH1

2.03e-0332112HP:0032560
HumanPhenoShort sperm flagella

CFAP44 DNAH1

2.16e-0333112HP:0032559
HumanPhenoAbnormal ciliary motility

SPAG1 DNAAF4

2.29e-0334112HP:0012262
HumanPhenoAbnormal breath sound

SPAG1 DNAAF4 DNAH1

2.46e-03133113HP:0030829
HumanPhenoAbnormal respiratory motile cilium physiology

SPAG1 DNAAF4

2.57e-0336112HP:0012261
HumanPhenoAbnormal sputum

SPAG1 DNAAF4 DNAH1

2.62e-03136113HP:0032016
HumanPhenoAirway obstruction

SPAG1 DNAAF4 DNAH1

2.68e-03137113HP:0006536
HumanPhenoAbdominal situs inversus

SPAG1 DNAAF4 DNAH1

2.97e-03142113HP:0003363
HumanPhenoAbnormal spatial orientation of the cardiac segments

SPAG1 DNAAF4 DNAH1

2.97e-03142113HP:0011534
HumanPhenoAbnormality of abdominal situs

SPAG1 DNAAF4 DNAH1

2.97e-03142113HP:0011620
HumanPhenoSitus inversus totalis

SPAG1 DNAAF4 DNAH1

2.97e-03142113HP:0001696
HumanPhenoHeterotaxy

SPAG1 DNAAF4 DNAH1

3.15e-03145113HP:0030853
HumanPhenoClubbing

SPAG1 DNAAF4 DNAH1

3.60e-03152113HP:0001217
HumanPhenoAbnormal sperm tail morphology

CFAP44 DNAH1

3.65e-0343112HP:0012868
HumanPhenoNeonatal respiratory distress

SPAG1 DNAAF4 DNAH1

3.74e-03154113HP:0002643
HumanPhenoChronic otitis media

SPAG1 DNAAF4 DNAH1

3.88e-03156113HP:0000389
HumanPhenoAbnormal pulmonary thoracic imaging finding

SPAG1 DNAAF4 DNAH1

3.95e-03157113HP:0031983
HumanPhenoIntestinal malrotation

SPAG1 DNAAF4 DNAH1

3.95e-03157113HP:0002566
HumanPhenoDextrocardia

SPAG1 DNAAF4 DNAH1

4.09e-03159113HP:0001651
HumanPhenoAbnormal anatomic location of the heart

SPAG1 DNAAF4 DNAH1

4.17e-03160113HP:0004307
HumanPhenoCough

SPAG1 DNAAF4 DNAH1

4.17e-03160113HP:0012735
HumanPhenoAbnormal pulmonary interstitial morphology

SPAG1 DNAAF4 DNAH1

4.24e-03161113HP:0006530
HumanPhenoAplasia/Hypoplasia of the vagina

WDPCP MAP3K1

4.35e-0347112HP:0011026
MousePhenodecreased respiratory mucosa goblet cell number

SERPINB3 SERPINB4

8.35e-055412MP:0010862
MousePhenoenlarged thymus cortex

CTSV RYR2

8.35e-055412MP:0013593
DomainArp3_met

ACTR3C ACTR3B

1.86e-053472IPR015623
DomainFHA

PPP1R8 MKI67 KIF13A

4.68e-0528473SM00240
DomainFHA_DOMAIN

PPP1R8 MKI67 KIF13A

6.39e-0531473PS50006
DomainFHA

PPP1R8 MKI67 KIF13A

6.39e-0531473PF00498
DomainFHA_dom

PPP1R8 MKI67 KIF13A

1.01e-0436473IPR000253
Domain-

PPP1R8 MKI67 KIF13A

1.01e-04364732.60.200.20
DomainRNase_Zc3h12a

ZC3H12B ZC3H12C

1.29e-047472PF11977
DomainRNase_Zc3h12_NYN

ZC3H12B ZC3H12C

1.29e-047472IPR021869
DomainSMAD_FHA_domain

PPP1R8 MKI67 KIF13A

3.03e-0452473IPR008984
DomainACTINS_ACT_LIKE

ACTR3C ACTR3B

1.03e-0319472PS01132
DomainTPR_1

SPAG1 DNAAF4 UTY

1.51e-0390473PF00515
DomainTPR_1

SPAG1 DNAAF4 UTY

1.51e-0390473IPR001440
DomainActin

ACTR3C ACTR3B

2.75e-0331472IPR004000
DomainActin

ACTR3C ACTR3B

2.75e-0331472PF00022
DomainACTIN

ACTR3C ACTR3B

2.75e-0331472SM00268
DomainSerpin_CS

SERPINB3 SERPINB4

2.93e-0332472IPR023795
DomainSerpin_dom

SERPINB3 SERPINB4

3.70e-0336472IPR023796
DomainSERPIN

SERPINB3 SERPINB4

3.90e-0337472SM00093
DomainSERPIN

SERPINB3 SERPINB4

3.90e-0337472PS00284
DomainSerpin

SERPINB3 SERPINB4

4.11e-0338472PF00079
DomainTPR

SPAG1 DNAAF4 UTY

4.18e-03129473SM00028
DomainSerpin_fam

SERPINB3 SERPINB4

4.33e-0339472IPR000215
DomainTPR_repeat

SPAG1 DNAAF4 UTY

4.55e-03133473IPR019734
DomainTPR-contain_dom

SPAG1 DNAAF4 UTY

6.36e-03150473IPR013026
DomainWW_DOMAIN_2

SETD2 IQGAP2

7.31e-0351472PS50020
DomainWW_DOMAIN_1

SETD2 IQGAP2

7.31e-0351472PS01159
DomainWW_dom

SETD2 IQGAP2

7.59e-0352472IPR001202
DomainTPR_8

SPAG1 UTY

7.87e-0353472PF13181
DomainTPR_REGION

SPAG1 DNAAF4 UTY

8.26e-03165473PS50293
DomainTPR

SPAG1 DNAAF4 UTY

8.26e-03165473PS50005
DomainZnf_CCCH

ZC3H12B ZC3H12C

9.37e-0358472IPR000571
DomainZF_C3H1

ZC3H12B ZC3H12C

9.37e-0358472PS50103
Pubmed

The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases.

SERPINB3 SERPINB4

1.94e-06249215203214
Pubmed

Increased Th1 immune response in SERPINB3 transgenic mice during acute liver failure.

SERPINB3 SERPINB4

1.94e-06249223354406
Pubmed

Serpin B4 isoform overexpression is associated with aberrant epithelial proliferation and lung cancer in idiopathic pulmonary fibrosis.

SERPINB3 SERPINB4

1.94e-06249222406480
Pubmed

Recurrent SERPINB3 and SERPINB4 mutations in patients who respond to anti-CTLA4 immunotherapy.

SERPINB3 SERPINB4

1.94e-06249227668655
Pubmed

Characterization of novel squamous cell carcinoma antigen-related molecules in mice.

SERPINB3 SERPINB4

1.94e-06249215504361
Pubmed

SCCA2-like serpins mediate genetic predisposition to skin tumors.

SERPINB3 SERPINB4

1.94e-06249212702576
Pubmed

Serpinb3 is overexpressed in the liver in presence of iron overload.

SERPINB3 SERPINB4

1.94e-06249228935635
Pubmed

Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.

SERPINB3 SERPINB4

1.94e-06249235022507
Pubmed

Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma.

ACTR3C ACTR3B

1.94e-06249211162478
Pubmed

Overexpression of SERPIN B3 promotes epithelial proliferation and lung fibrosis in mice.

SERPINB3 SERPINB4

1.94e-06249221403642
Pubmed

SERPINB3/B4 contributes to early inflammation and barrier dysfunction in an experimental murine model of atopic dermatitis.

SERPINB3 SERPINB4

1.94e-06249225111616
Pubmed

Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter.

SERPINB3 SERPINB4

1.94e-06249211267667
Pubmed

Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours.

SERPINB3 SERPINB4

1.94e-06249229491058
Pubmed

Squamous cell carcinoma antigen production in nasal inverted papilloma.

SERPINB3 SERPINB4

1.94e-06249223168150
Pubmed

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.

SERPINB3 SERPINB4

1.94e-06249211863458
Pubmed

IgM-linked SerpinB3 and SerpinB4 in sera of patients with chronic liver disease.

SERPINB3 SERPINB4

1.94e-06249222808225
Pubmed

Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma.

SERPINB3 SERPINB4

1.94e-06249214970861
Pubmed

Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas.

SERPINB3 SERPINB4

1.94e-06249210653592
Pubmed

Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer.

SERPINB3 SERPINB4

1.94e-06249229112685
Pubmed

Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.

SERPINB3 SERPINB4

1.94e-06249210956412
Pubmed

Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells.

ACTR3C ACTR3B

1.94e-06249214651955
Pubmed

Tumor-related protein, the squamous cell carcinoma antigen binds to the intracellular protein carbonyl reductase.

SERPINB3 SERPINB4

1.94e-06249220428762
Pubmed

SerpinB3 as a Pro-Inflammatory Mediator in the Progression of Experimental Non-Alcoholic Fatty Liver Disease.

SERPINB3 SERPINB4

1.94e-06249235874657
Pubmed

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.

PPP1R8 MCMBP FRMD6 SERPINB3 SERPINB4 MKI67

2.19e-0627049624366813
Pubmed

Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells.

SERPINB3 SERPINB4

5.83e-06349219070595
Pubmed

A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases.

SERPINB3 SERPINB4

5.83e-0634929828132
Pubmed

Anti-apoptotic effects of SERPIN B3 and B4 via STAT6 activation in macrophages after infection with Toxoplasma gondii.

SERPINB3 SERPINB4

5.83e-06349222451727
Pubmed

A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene.

SERPINB3 SERPINB4

5.83e-0634927724531
Pubmed

Differentially expressed proteins in human breast cancer cells sensitive and resistant to paclitaxel.

SERPINB3 SERPINB4

5.83e-06349224898082
Pubmed

A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma.

SERPINB3 SERPINB4

5.83e-06349221126757
Pubmed

Diagnostic and prognostic role of SCCA-IgM serum levels in hepatocellular carcinoma (HCC).

SERPINB3 SERPINB4

5.83e-06349224635038
Pubmed

Heparin enhances serpin inhibition of the cysteine protease cathepsin L.

SERPINB3 SERPINB4

5.83e-06349219959474
Pubmed

Uteroglobin suppresses SCCA gene expression associated with allergic asthma.

SERPINB3 SERPINB4

5.83e-06349215677460
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

MCMBP KLF10 BCLAF1 EIF4G1 MKI67 ELF1 KIF13A

6.45e-0650349716964243
Pubmed

Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo.

MKI67 CTSV

1.16e-05449225222295
Pubmed

Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase.

SERPINB3 SERPINB4

1.16e-05449216549498
Pubmed

A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages.

ZC3H12B ZC3H12C

1.16e-05449218178554
Pubmed

Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1.

SERPINB3 SERPINB4

1.16e-05449212949073
Pubmed

Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury.

SERPINB3 SERPINB4

1.16e-05449221576355
Pubmed

Primary Ciliary Dyskinesia

SPAG1 DNAAF4 DNAH1

1.27e-053249320301301
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

MCMBP SERPINB3 EIF4G1 MKI67 ACTR3B ME2 MAP3K1 DNPEP

2.18e-0584449825963833
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

PPP1R8 UBTD1 BCLAF1 EIF4G1 MKI67 ACTR3B TFAM

3.69e-0566049732780723
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

SERPINB3 SERPINB4 BCLAF1 MKI67 CKAP5

4.06e-0527249531010829
Pubmed

Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation.

MKI67 TFAM

4.07e-05749229021295
Pubmed

Cathepsin proteases have distinct roles in trophoblast function and vascular remodelling.

MKI67 CTSV

5.42e-05849218776147
Pubmed

UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death.

MKI67 UTY

5.42e-05849236412518
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

PPP1R8 FRMD6 IQGAP2 SERPINB3 SERPINB4 BCLAF1 EIF4G1 ACTR3B DNPEP

6.72e-05128449917353931
Pubmed

Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development.

SEMA3D MKI67

6.96e-05949227160901
Pubmed

Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations.

ABI3BP RYR2

6.96e-05949223829686
Pubmed

Deletion of Tfam in Prx1-Cre expressing limb mesenchyme results in spontaneous bone fractures.

MKI67 TFAM

8.69e-051049235947192
Pubmed

The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells.

MKI67 TFAM

8.69e-051049221780252
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

FAT1 FRMD6 IQGAP2 BCLAF1 MKI67 DCLRE1A RYR2

1.03e-0477749735844135
Pubmed

Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus.

SERPINB3 SERPINB4

1.06e-041149215203215
Pubmed

Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.

ZC3H12C RYR2

1.06e-041149217903301
Pubmed

Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability.

MKI67 KIF13A

1.27e-041249232044971
Pubmed

RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development.

MKI67 RYR2

1.27e-041249235472321
Pubmed

IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade.

IQGAP2 MKI67

1.27e-041249218604197
Pubmed

UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.

MKI67 UTY

1.50e-041349222192413
Pubmed

Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse.

SERPINB3 SERPINB4

1.50e-041349211863365
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

NIBAN1 BCLAF1 EIF4G1 CKAP5 ELF1

1.72e-0437049522922362
Pubmed

MED12 regulates a transcriptional network of calcium-handling genes in the heart.

MKI67 RYR2

1.75e-041449228724790
Pubmed

Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter.

GCNT1 CTSV

1.75e-04144922034277
Pubmed

A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.

KLF10 ELF1

1.75e-041449210976766
Pubmed

Astrocyte-intrinsic and -extrinsic Fat1 activities regulate astrocyte development and angiogenesis in the retina.

FAT1 MKI67

1.75e-041449235050341
Pubmed

Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis.

SETD2 MKI67

1.75e-041449238265933
Pubmed

The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease.

SERPINB3 SERPINB4

2.02e-041549230704515
Pubmed

KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.

MKI67 UTY

2.30e-041649235212626
Pubmed

Deficiency in the secreted protein Semaphorin3d causes abnormal parathyroid development in mice.

SEMA3D MKI67

2.30e-041649230979723
Pubmed

LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization.

MKI67 CKAP5

2.61e-041749237072811
Pubmed

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.

IQGAP2 BCLAF1 EIF4G1 CKAP5

2.69e-0422149429991511
Pubmed

Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development.

FAT1 MKI67

2.93e-041849226209645
Pubmed

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

SERPINB3 SERPINB4 BCLAF1 MKI67 DCLRE1A TFAM

2.99e-0465249631180492
Pubmed

Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.

SERPINB4 BCLAF1 EIF4G1 MKI67

3.97e-0424549421182205
Pubmed

Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling.

MKI67 WDPCP

4.01e-042149229487191
Pubmed

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SETD2 ZC3H12C ACAP3

4.09e-0410249311214970
Pubmed

A genomic analysis of rat proteases and protease inhibitors.

SERPINB3 SERPINB4

4.83e-042349215060002
Pubmed

Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones.

KLF10 DNPEP

5.26e-042449224583261
Pubmed

Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.

MKI67 RYR2

5.71e-042549238877142
Pubmed

Tshz1 Regulates Pancreatic β-Cell Maturation.

MKI67 TFAM

5.71e-042549225918232
Pubmed

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.

MCMBP BCLAF1 EIF4G1 CKAP5

5.80e-0427149425737280
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

SPAG1 MCMBP SERPINB3 BCLAF1 EIF4G1 CKAP5 ME2 TFAM

5.99e-04136749832687490
Pubmed

TFAM is required for maturation of the fetal and adult intestinal epithelium.

MKI67 TFAM

6.18e-042649229684311
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

IQGAP2 EIF4G1 MKI67 CKAP5 TFAM MAP3K1

6.66e-0475949635915203
Pubmed

TRAIP regulates replication fork recovery and progression via PCNA.

MCMBP MKI67

6.67e-042749227462463
Pubmed

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.

CKAP5 RYR2

6.67e-042749218468998
Pubmed

Protein translation rate determines neocortical neuron fate.

EIF4G1 MKI67

6.67e-042749238849354
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

BCLAF1 EIF4G1 RYR2

7.06e-0412349326912792
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

SETD2 BCLAF1 EIF4G1 MKI67 CKAP5 ELF1

7.38e-0477449615302935
Pubmed

Zfhx3 is required for the differentiation of late born D1-type medium spiny neurons.

FRMD6 MKI67

7.71e-042949231491374
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

MCMBP SERPINB3 BCLAF1 EIF4G1 MKI67 CKAP5 ME2 DNPEP

7.86e-04142549830948266
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

IQGAP2 ACTR3C BCLAF1 EIF4G1 CKAP5 ACTR3B TFAM DNPEP

8.08e-04143149837142655
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SPAG1 ABI3BP IQGAP2 BCLAF1 TRO EIF4G1 TFAM RYR2

8.49e-04144249835575683
Pubmed

Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling.

SERPINB3 SERPINB4

8.81e-043149236971701
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

NIBAN1 UBTD1 TRIM61 ACTR3B WDPCP RYR2

9.58e-0481449623251661
Pubmed

Hypertrophic Cardiomyopathy Overview

KLF10 RYR2

1.06e-033449220301725
Pubmed

Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice.

MKI67 MAP3K1

1.06e-033449223300479
Pubmed

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.

SERPINB3 BCLAF1 EIF4G1 CFAP44 TFAM

1.11e-0355849527591049
Pubmed

Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies.

MKI67 GCNT1

1.12e-033549232179912
Pubmed

The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.

UBTD1 BCLAF1 ACTR3B TFAM

1.18e-0332849423398456
Pubmed

The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.

BCLAF1 EIF4G1 MKI67 CKAP5

1.20e-0333049432529326
Cytoband18q21.3

SERPINB3 SERPINB4

6.10e-051149218q21.3
Cytoband8q22.2

SPAG1 KLF10

2.78e-04234928q22.2
Cytoband3p21.1

ITIH1 DNAH1

9.35e-04424923p21.1
CytobandEnsembl 112 genes in cytogenetic band chr18q21

SERPINB3 SERPINB4 ME2

1.39e-03205493chr18q21
Cytoband7q36.1

ACTR3C ACTR3B

2.87e-03744927q36.1
CytobandEnsembl 112 genes in cytogenetic band chr3p21

SETD2 ITIH1 DNAH1

4.71e-03316493chr3p21
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

SPAG1 DNAAF4 UTY

1.19e-03115333769
GeneFamilyZinc fingers CCCH-type

ZC3H12B ZC3H12C

1.85e-033533273
GeneFamilySerpin peptidase inhibitors

SERPINB3 SERPINB4

2.07e-0337332739
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_LYMPHATIC_ENDOTHELIAL_CELL

SEMA3D NIBAN1 UBTD1 ABI3BP FRMD6 GCNT1 CCDC102B MAP3K1

5.06e-07382498M45756
CoexpressionMCCLUNG_COCAIN_REWARD_4WK

KLF10 SERPINB3 SERPINB4 DCLRE1A

1.25e-0576494MM682
CoexpressionHE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL

NIBAN1 FRMD6 IQGAP2 MKI67 DCLRE1A TRIM68 GCNT1 CCDC102B TMEM19 CTSV

2.09e-0510544910M45798
CoexpressionGSE36476_YOUNG_VS_OLD_DONOR_MEMORY_CD4_TCELL_16H_TSST_ACT_UP

MCMBP SERPINB4 DCLRE1A CCDC102B ME2

3.24e-05196495M5313
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEMA3D ABI3BP FRMD6 IPCEF1 CCDC102B

1.69e-0618249553c267ee327e116dbd89d5927ed3bdf78d25ee62
ToppCellBasal_cells-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

FAT1 FRMD6 SERPINB3 SERPINB4 TRO

2.14e-06191495a98915bad9a4a61dd4cbca798914849b805f4a19
ToppCellControl_saline-Epithelial_airway-airway_epithelial|Control_saline / Treatment groups by lineage, cell group, cell type

DNAAF4 SERPINB4 CFAP44 CTSV DNAH1

2.56e-06198495e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

DNAAF4 SERPINB4 CFAP44 CTSV DNAH1

2.56e-06198495e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SEMA3D FAT1 ABI3BP FRMD6 RYR2

2.69e-062004958988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

SEMA3D FAT1 ABI3BP FRMD6 RYR2

2.69e-06200495c5e051f1aac8dda376c342a9932785a23450e073
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

SEMA3D FAT1 ABI3BP FRMD6 RYR2

2.69e-062004959d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_3|Control_saline / Treatment groups by lineage, cell group, cell type

PRSS35 NIBAN1 FAT1 CCDC102B RYR2

2.69e-06200495b0866b497aa71d06cef25f9a335fa584e95fa7e0
ToppCellControl_saline-Mesenchymal_myocytic|Control_saline / Treatment groups by lineage, cell group, cell type

FAT1 ABI3BP FRMD6 CCDC102B RYR2

2.69e-062004955ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_only / Treatment groups by lineage, cell group, cell type

PRSS35 NIBAN1 FAT1 CCDC102B RYR2

2.69e-062004957c62678cf408aaaf98d6df0fb27814d2007c4521
ToppCellTracheal-10x5prime-Stromal-Pericyte-Muscle_pericyte_pulmonary|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PRSS35 CCDC102B ITIH1

2.03e-05484930b71435d798c6b25089a16b25d1d535f3c780d30
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Cpa6|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PRSS35 KLF10 ABI3BP IPCEF1

2.48e-0515449412cbc38bc1f7231c67e1d2d5e86e95bc12e24682
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PRSS35 KLF10 ABI3BP IPCEF1

2.61e-05156494fe383ce3a0c37f7343d7026cb51260a04d4c2829
ToppCellfacs-Lung-EPCAM-3m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SETD2 MKI67 ANKRD49 ME2

2.95e-05161494a7e74bc80ac11250e353e5614b19c05793fc2e95
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FAT1 FRMD6 ZC3H12C MAP3K1

3.57e-051694942833a8a7094e4d407eb923f2bc59b9b112c6bae4
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IQGAP2 IPCEF1 MKI67 ME2

3.65e-05170494da4dde7d0491ccc298cec7474a6a76ff3db36a4c
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9|TCGA-Bladder / Sample_Type by Project: Shred V9

FRMD6 SERPINB3 SERPINB4 TMEM19

3.73e-05171494adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRSS35 NIBAN1 TP53TG5 CCDC102B

3.82e-05172494107417cfab7775bc1f80807115047abfb50b7a7e
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IQGAP2 IPCEF1 MKI67 ME2

3.82e-051724944bdcf1ae2a1cfba0272c54072e37fb7958904321
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Lymphocytic-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPAG1 IQGAP2 DNAAF4 IPCEF1

4.00e-051744946987fe7959afce347282f632abc16d800ccab7c4
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FAT1 TP53TG5 CCDC102B RYR2

4.00e-05174494015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FRMD6 SERPINB3 SERPINB4 MKI67

4.09e-051754949142ed8ca2f1c0c518deb21988221406f62fe38c
ToppCellP28-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NIBAN1 IQGAP2 MKI67 ME2

4.56e-051804941e819c5c87704ec6535dfeaae56561895e239d07
ToppCelldroplet-Lung-nan-18m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MKI67 CKAP5 DCLRE1A ACTR3B

4.56e-0518049443fd5c498a87bb078d101298b472656f3294686a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA3D NIBAN1 ABI3BP FRMD6

4.76e-0518249441b070085edba7a58b81c20aa4942d06f745acf8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA3D NIBAN1 ABI3BP FRMD6

4.76e-051824945e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA3D NIBAN1 ABI3BP FRMD6

4.76e-05182494b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEMA3D ABI3BP FRMD6 IPCEF1

4.86e-051834944d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCelldroplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MKI67 CKAP5 DCLRE1A ACTR3B

4.86e-05183494e91f00b75d43ee6293fdd4a129b789cd95f8d11a
ToppCell3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEMA3D PTCHD3 FRMD6 IPCEF1

4.97e-05184494968afa6b5ba84169377a24c150bb68749fa674d9
ToppCell3'-Broncho-tracheal-Endothelial-Lymphatic_EC|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEMA3D PTCHD3 FRMD6 IPCEF1

4.97e-0518449415cbddea9efb2346a2028d77edfe9ba32923568f
ToppCell3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEMA3D PTCHD3 FRMD6 IPCEF1

4.97e-051844940087c605c161fd8a39aa394f51994a04e8353bf1
ToppCell3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEMA3D PTCHD3 FRMD6 IPCEF1

4.97e-05184494920f95625978132c2b6c76654ef6298244103e2d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

NIBAN1 ABI3BP IPCEF1 RYR2

4.97e-05184494d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PRSS35 SEMA3D ABI3BP CTSV

5.07e-05185494c85bba1210f1d389add3e40be9b96abac40cf8c1
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NIBAN1 FAT1 CCDC102B RYR2

5.18e-051864944780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEMA3D ABI3BP FRMD6 IPCEF1

5.18e-0518649440070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 ABI3BP IPCEF1 MAP3K1

5.18e-051864945c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NIBAN1 FAT1 CCDC102B RYR2

5.18e-05186494a95744b8649096bd7cfc3591a02841fa411085b3
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

ABI3BP FRMD6 CCDC102B RYR2

5.29e-05187494bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

SEMA3D NIBAN1 KIF13A RYR2

5.40e-0518849434e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-osteochondral_precursor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PRSS35 FAT1 FRMD6 CCDC102B

5.51e-051894941ff4f8da572bdc6356e9df9f41a7f62c81d4c570
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT1 ABI3BP CCDC102B RYR2

5.51e-051894947ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NIBAN1 ABI3BP FRMD6 RYR2

5.51e-0518949445e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellIPF-Epithelial-Basal|IPF / Disease state, Lineage and Cell class

FAT1 FRMD6 SERPINB3 SERPINB4

5.63e-05190494ea19e9ce954f2dfde97388db9695325cd92ab88f
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PRSS35 NIBAN1 FAT1 RYR2

5.63e-05190494d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

ABI3BP FRMD6 CCDC102B RYR2

5.63e-051904943a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCellILEUM-non-inflamed-(7)_Endothelial_cell-(7)_Lymphatics|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SEMA3D ABI3BP CCDC102B MAP3K1

5.63e-051904949ce301841ce9486701fa28eb2a9929e35d476878
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SEMA3D ABI3BP CCDC102B RYR2

5.74e-05191494fa380a8752de158974b2ae5e741573439719cc0d
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEMA3D ABI3BP FRMD6 RYR2

5.74e-05191494b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

SETD2 SPAG1 BCLAF1 ELF1

5.74e-051914941ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCellCOVID-19-T_cells|COVID-19 / group, cell type (main and fine annotations)

NIBAN1 IQGAP2 IPCEF1 MKI67

5.74e-051914947f64add931b64b8d35836fa6bee9ebab593844d3
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT1 ABI3BP CCDC102B RYR2

5.74e-0519149408042952431ca1a6fd7dfc13f36eb28643979598
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SEMA3D ABI3BP FRMD6 CCDC102B

5.86e-051924948d56e360ebc624ca4cd7f0af4f3cc599c244f134
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SEMA3D ABI3BP FRMD6 CCDC102B

5.86e-05192494e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCellIPF-Epithelial-Basal|World / Disease state, Lineage and Cell class

FAT1 FRMD6 SERPINB3 SERPINB4

5.86e-051924949b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT1 ABI3BP CCDC102B RYR2

5.86e-05192494992d08092edbc68c47b945deb8708379738c239a
ToppCellILEUM-inflamed-(7)_Endothelial_cell-(7)_Lymphatics|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SEMA3D ABI3BP CCDC102B MAP3K1

5.86e-05192494d43caf42ec744e895137f31ef65a990e250669d2
ToppCellMesenchymal-matrix_fibroblast_2_cell|World / Lineage, Cell type, age group and donor

SEMA3D ABI3BP FRMD6 CCDC102B

5.86e-05192494a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

SEMA3D ABI3BP FRMD6 CCDC102B

5.98e-051934949ab47b360bee1d4f1092c2269e58acebe9584021
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRSS35 NIBAN1 MKI67 CKAP5

5.98e-05193494a332dfdcc48c405020014e644aa4d14fda98cc86
ToppCellControl-Fibroblasts-Intermediate_pathological_FB|Control / group, cell type (main and fine annotations)

ABI3BP FRMD6 CCDC102B RYR2

6.10e-0519449403a269f75a481ea54aea8e6444605db8d6df493d
ToppCellnucseq-Mesenchymal-Myocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FAT1 FRMD6 CCDC102B RYR2

6.10e-051944942d66091097e106c7bee22e5281f50724700bdf8d
ToppCelldistal-2-Endothelial-Lymphatic|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SEMA3D UBTD1 PTCHD3 FRMD6

6.22e-051954948e0f67a67af3bc0b16f48a621f74540f136383b7
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

SPAG1 DNAAF4 CFAP44 DNAH1

6.22e-0519549460067b5359174f0d1a8b5748bfc0690762e9e740
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PRSS35 ABI3BP CCDC102B RYR2

6.35e-05196494525d6c8a277364e624e7cc586275f8a891436b57
ToppCellIPF-Stromal-Myofibroblast|IPF / Disease state, Lineage and Cell class

ABI3BP FRMD6 CCDC102B RYR2

6.35e-051964942d0a48e49b3b37bb66e33e74c52915911e1f8a74
ToppCelldistal-Endothelial-Lymphatic|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SEMA3D UBTD1 PTCHD3 FRMD6

6.35e-051964943e8a20e1d163dcbd3bbd99fe179d54af02298af0
ToppCellIPF-Stromal-Myofibroblast|World / Disease state, Lineage and Cell class

ABI3BP FRMD6 CCDC102B RYR2

6.35e-051964947fc9894ceb79dab9f0495acc84e2d6d0d1c69bb7
ToppCellBasal_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

FAT1 FRMD6 SERPINB3 SERPINB4

6.35e-051964943b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT1 SERPINB3 SERPINB4 MKI67

6.47e-05197494fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCellCOVID-19-Fibroblasts-Intermediate_pathological_FB|COVID-19 / group, cell type (main and fine annotations)

ABI3BP FRMD6 CCDC102B RYR2

6.47e-05197494f1c8936986123a3151140c374fcd62d6705c530b
ToppCellBasal_cells|World / lung cells shred on cell class, cell subclass, sample id

FAT1 FRMD6 SERPINB3 SERPINB4

6.47e-0519749424360b660000bdfb999d58fbf4e29585a97e1785
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

ABI3BP FRMD6 CCDC102B RYR2

6.47e-05197494fb847f2277609c31fffcdf49517243ce0684facf
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT1 SERPINB3 SERPINB4 MKI67

6.47e-0519749461c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT1 SERPINB3 SERPINB4 MKI67

6.47e-05197494dcabea5c50c133c9a4e294e447462d0393174ea7
ToppCelldistal-Endothelial-Lymphatic-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SEMA3D UBTD1 PTCHD3 FRMD6

6.47e-051974948f2e19409ebe9a490d5a245fa82c765ed6d77c3e
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

ABI3BP FRMD6 CCDC102B RYR2

6.60e-05198494df3de77216f5c5d6141ec44d01c56b942f611838
ToppCellEpithelial_cells-Basal_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

FRMD6 SERPINB3 SERPINB4 GCNT1

6.60e-051984944235005c49fc2b29ad3a0ee6b608f0109d04f775
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT1 SERPINB3 SERPINB4 MKI67

6.60e-05198494e06d41a7254a09e037ec404be2d8c352d5cbd7f4
ToppCellIPF-Stromal|IPF / Disease state, Lineage and Cell class

ABI3BP FRMD6 CCDC102B RYR2

6.60e-05198494ece914c32c9b123b779aa9624b92e6230763a20e
ToppCellFetal_29-31_weeks-Mesenchymal|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SEMA3D ABI3BP CCDC102B RYR2

6.60e-0519849421cf4d81386761d09d0f6829c01c198e5524176d
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FAT1 ABI3BP FRMD6 IQGAP2

6.73e-0519949438cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Neuroepithelial|6m / Sample Type, Dataset, Time_group, and Cell type.

NIBAN1 ABI3BP FRMD6 CCDC102B

6.86e-052004942cc98abf11f5b58707de45a2282f03d47f00f035
ToppCellLPS_anti-TNF-Mesenchymal_myocytic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FAT1 ABI3BP CCDC102B RYR2

6.86e-0520049467dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte|LPS_only / Treatment groups by lineage, cell group, cell type

NIBAN1 FAT1 CCDC102B RYR2

6.86e-052004948c8ef2b19ab5b1bfc0fae6c38a330f464f28e86f
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Neuroepithelial-Proteoglycan-expressing_cell|6m / Sample Type, Dataset, Time_group, and Cell type.

NIBAN1 ABI3BP FRMD6 CCDC102B

6.86e-052004940f7431f670f3a175377cefae3479403a881bb8fb
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAT1 FRMD6 SERPINB3 SERPINB4

6.86e-052004948827653738a931e4a4545e0c7d75be12bed40740
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte|Control_saline / Treatment groups by lineage, cell group, cell type

NIBAN1 FAT1 CCDC102B RYR2

6.86e-05200494cb7ef774b6d300f8019c5b16a04e3ebd165e4f1c
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FAT1 ABI3BP FRMD6 CCDC102B

6.86e-05200494f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PRSS35 NIBAN1 FAT1 CCDC102B

6.86e-05200494a3a1e35934d676c39f917652e50c502cb2f613c1
ToppCellCOVID-19|World / Disease, condition lineage and cell class

SETD2 IQGAP2 BCLAF1 ELF1

6.86e-052004947dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SERPINB4 CFAP44 CTSV DNAH1

6.86e-05200494da12821e8a0657869ca0f75d351cce2d7605a505
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SEMA3D FAT1 ABI3BP FRMD6

6.86e-0520049487827041663013f5e7273168dc8709d69840e7ce
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

NIBAN1 FAT1 CCDC102B RYR2

6.86e-05200494c06426f877919bdd267ea2fd7e7973c6619832ae
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA3D ABI3BP FRMD6 CCDC102B

6.86e-0520049474e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCellLPS_only-Mesenchymal_myocytic|LPS_only / Treatment groups by lineage, cell group, cell type

FAT1 ABI3BP CCDC102B RYR2

6.86e-052004948bc9923f82bfb836e2f524204c92050edeae8ca5
ToppCellLPS_IL1RA_TNF-Epithelial_airway|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SERPINB4 CFAP44 CTSV DNAH1

6.86e-0520049472c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCellmild-immature_Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SPAG1 WDPCP DNAH1

2.35e-041094932f03d6ee8b13424cc6a5bc60ac3461b44dff9d79
ToppCellLPS-antiTNF-Unknown-Endothelial-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MKI67 CCDC102B RYR2

4.12e-0413249302491930097b75aaeedab9e8200711b0dc610944
DiseasePolynesian Bronchiectasis

SPAG1 DNAAF4 DNAH1

2.71e-0535493C4317124
DiseaseCiliary Dyskinesia, Primary, 1, With Or Without Situs Inversus

SPAG1 DNAAF4 DNAH1

2.71e-0535493C4551906
DiseaseKartagener Syndrome

SPAG1 DNAAF4 DNAH1

2.71e-0535493C0022521
DiseasePrimary ciliary dyskinesia

SPAG1 DNAAF4 DNAH1

2.96e-0536493cv:C0008780
DiseasePrimary Ciliary Dyskinesia

SPAG1 DNAAF4 DNAH1

6.63e-0547493C4551720
Diseaseexercise test

ZC3H12C RYR2

5.04e-0420492EFO_0004328
Diseasecolorectal cancer (is_implicated_in)

SETD2 FAT1 MKI67

1.08e-03121493DOID:9256 (is_implicated_in)
Diseaseradius bone mineral density

ACTR3B MAP3K1

1.46e-0334492EFO_0007933
Diseasesleep measurement

ACTR3B CFAP44 RYR2

1.48e-03135493EFO_0004870
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

FAT1 MAP3K1

2.56e-0345492DOID:3748 (is_implicated_in)
Diseaseresponse to angiotensin-converting enzyme inhibitor, Cough

NIBAN1 ACTR3B

2.67e-0346492EFO_0005325, HP_0012735
Diseasehepatocellular carcinoma (implicated_via_orthology)

IQGAP2 CTSV

3.02e-0349492DOID:684 (implicated_via_orthology)
Diseasesusceptibility to common cold measurement

NIBAN1 ACTR3B

3.66e-0354492EFO_0008417
DiseaseHypertrophic Cardiomyopathy

KLF10 RYR2

4.07e-0357492C0007194
DiseasePsoriasis

MKI67 ZC3H12C

4.07e-0357492C0033860
DiseasePustulosis of Palms and Soles

MKI67 ZC3H12C

4.07e-0357492C0030246
Diseasealcohol use disorder (implicated_via_orthology)

CTSV UTY RYR2

4.19e-03195493DOID:1574 (implicated_via_orthology)
Diseasebasophil measurement

ELF1 WDPCP

4.50e-0360492EFO_0803539

Protein segments in the cluster

PeptideGeneStartEntry
KATCPKYIKWTQREK

ELF1

221

P32519
KETEKWNIKPESKYF

DNPEP

61

Q9ULA0
KSVDWRKKGYVTPVK

CTSV

116

O60911
EFAKYDVDPRKWIKQ

ACTR3B

241

Q9P1U1
RQDKEAWIKDKYVEK

ACAP3

501

Q96P50
IQQRKKEWEELYKSK

CFAP44

1136

Q96MT7
WKVYVKKPLDREKRD

FAT1

2976

Q14517
GDIKDKVTAWKQYRK

ITIH1

111

P19827
KEFAKYDVDPQKWIK

ACTR3C

111

Q9C0K3
EWYRLQEKKMEKDPS

ANKRD49

61

Q8WVL7
KKNESPFWKLYESVK

MKI67

231

P46013
LEKKQKLAESRDYPW

WDPCP

76

O95876
PKEWKKEASKVRQYE

FRMD6

81

Q96NE9
EDPKSQKLKYKWCEV

DNAH1

291

Q9P2D7
PKDFYDKIEAKKWQE

CKAP5

281

Q14008
DDPKLTARKYREWKV

IPCEF1

381

Q8WWN9
KEEEWDPEYTPKSKK

BCLAF1

831

Q9NYF8
YKSDQWKPLNLEEKK

EIF4G1

596

Q04637
PEDKAKYVKERTWRS

ME2

546

P23368
AWKEYQRKAEEQKKI

DNAAF4

161

Q8WXU2
SWKSDFKKYVENRPV

KLF10

51

Q13118
SEEDIWEYKSKRKPK

DCLRE1A

6

Q6PJP8
KEERWKKRYEVVNGK

GCNT1

251

Q02742
KEKEIYRWPIKESLK

RYR2

2766

Q92736
KWKYEELKESKPKNV

CCDC102B

296

Q68D86
VTKKVDYWDKDVRQK

PTCHD3

661

Q3KNS1
PDWEKKVIEYFKEKL

MCMBP

26

Q9BTE3
EWKEKVPEAKRLYGK

KIF13A

761

Q9H1H9
TKAKQPYREDTEWLK

MAP3K1

1231

Q13233
ERYEWNKLKSVKSPV

UTY

1201

O14607
AVNEPKKKKYAKEAW

PPP1R8

326

Q12972
LAPEYQKELWDAKKK

IQGAP2

251

Q13576
QRWRELPDSKKKIYQ

TFAM

86

Q00059
KEEKFWPNKNTYKSI

SERPINB3

196

P29508
NFKKIYWPAAKERVE

SEMA3D

101

O95025
PKKKEYKEWKSQVQS

TP53TG5

121

Q9Y2B4
RKKLEEYNAPWKERV

TRIM61

141

Q5EBN2
WEFEKYQRLLEKKQP

TRIM68

186

Q6AZZ1
EDIKKWKERYVVVKN

NIBAN1

81

Q9BZQ8
RVQKKDPKDWAVQYR

TRO

626

Q12816
DPDKKNWKRKIIAVY

PRSS35

356

Q8N3Z0
KKKTPRDYAEWDKFD

SPAG1

151

Q07617
KEEKFWPNKNTYKSV

SERPINB4

196

P48594
NEPLKKERLKWKSDY

UBTD1

26

Q9HAC8
YRDLQVEKPEWKKFI

ZC3H12B

301

Q5HYM0
WKDLKEVYRIPKKSQ

SETD2

2016

Q9BYW2
TKWKGEVKKRLDSEY

TMEM19

111

Q96HH6
YRDLANEKPEWKKFI

ZC3H12C

356

Q9C0D7
REKDKEKKWIFQICP

ABI3BP

161

Q7Z7G0