Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF419 GLIS3 ZNF133 ZNF561 RORA ZNF492 STOX2 ZNF721 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	1.21e-06	1459	43	14	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF419 GLIS3 ZNF133 ZNF561 RORA ZNF492 ZNF721 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	5.15e-06	1412	43	13	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF419 GLIS3 ZNF561 RORA ZNF492 ZNF721 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718	4.74e-05	1244	43	11	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF419 GLIS3 ZNF561 RORA ZNF492 ZNF721 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718	5.77e-05	1271	43	11	GO:0000987
GeneOntologyMolecularFunction	pre-mRNA 3'-splice site binding	ZRSR2P1 ZRSR2	9.45e-05	7	43	2	GO:0030628
GeneOntologyBiologicalProcess	regulation of RNA splicing	TRA2A SRRM1 SRSF10 SFSWAP CLK1	6.85e-05	207	43	5	GO:0043484
GeneOntologyBiologicalProcess	RNA splicing	TRA2A SRRM1 ZRSR2P1 SRSF10 SFSWAP ZRSR2 CLK1	7.32e-05	502	43	7	GO:0008380
GeneOntologyBiologicalProcess	mRNA splicing, via spliceosome	TRA2A SRRM1 ZRSR2P1 SRSF10 SFSWAP ZRSR2	9.29e-05	358	43	6	GO:0000398
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	TRA2A SRRM1 ZRSR2P1 SRSF10 SFSWAP ZRSR2	9.29e-05	358	43	6	GO:0000377
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions	TRA2A SRRM1 ZRSR2P1 SRSF10 SFSWAP ZRSR2	9.88e-05	362	43	6	GO:0000375
GeneOntologyBiologicalProcess	regulation of mRNA splicing, via spliceosome	TRA2A SRRM1 SRSF10 SFSWAP	1.49e-04	129	43	4	GO:0048024
GeneOntologyBiologicalProcess	regulation of mRNA processing	TRA2A SRRM1 SRSF10 SFSWAP	3.24e-04	158	43	4	GO:0050684
GeneOntologyCellularComponent	U2AF complex	ZRSR2P1 ZRSR2	9.03e-05	7	44	2	GO:0089701
Domain	zf-C2H2_6	ZNF419 ZNF133 ZNF561 ZNF492 ZNF721 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718	1.83e-09	314	43	10	PF13912
Domain	KRAB	ZNF419 ZNF133 ZNF561 ZNF492 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	6.45e-09	358	43	10	PS50805
Domain	KRAB	ZNF419 ZNF133 ZNF561 ZNF492 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	6.45e-09	358	43	10	PF01352
Domain	KRAB	ZNF419 ZNF133 ZNF561 ZNF492 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	8.61e-09	369	43	10	SM00349
Domain	KRAB	ZNF419 ZNF133 ZNF561 ZNF492 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	8.84e-09	370	43	10	IPR001909
Domain	-	ZNF419 GLIS3 ZNF133 ZNF561 ZNF492 ZNF721 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	2.64e-08	679	43	12	3.30.160.60
Domain	zf-C2H2	ZNF419 GLIS3 ZNF133 ZNF561 ZNF492 ZNF721 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	3.30e-08	693	43	12	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF419 GLIS3 ZNF133 ZNF561 ZNF492 ZNF721 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	3.35e-08	694	43	12	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF419 GLIS3 ZNF133 ZNF561 ZNF492 ZNF721 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	1.12e-07	775	43	12	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF419 GLIS3 ZNF133 ZNF561 ZNF492 ZNF721 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	1.15e-07	777	43	12	PS00028
Domain	Znf_C2H2-like	ZNF419 GLIS3 ZNF133 ZNF561 ZNF492 ZNF721 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	1.50e-07	796	43	12	IPR015880
Domain	Znf_C2H2	ZNF419 GLIS3 ZNF133 ZNF561 ZNF492 ZNF721 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	1.69e-07	805	43	12	IPR007087
Domain	ZnF_C2H2	ZNF419 GLIS3 ZNF133 ZNF561 ZNF492 ZNF721 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	1.76e-07	808	43	12	SM00355
Domain	U2AF_small	ZRSR2P1 ZRSR2	5.15e-05	5	43	2	IPR009145
Domain	SURP	SFSWAP U2SURP	7.72e-05	6	43	2	PS50128
Domain	Surp	SFSWAP U2SURP	7.72e-05	6	43	2	PF01805
Domain	SWAP	SFSWAP U2SURP	7.72e-05	6	43	2	SM00648
Domain	Surp	SFSWAP U2SURP	7.72e-05	6	43	2	IPR000061
Domain	RRM_1	TRA2A ZRSR2P1 SRSF10 ZRSR2 U2SURP	1.11e-04	208	43	5	PF00076
Domain	RRM	TRA2A ZRSR2P1 SRSF10 ZRSR2 U2SURP	1.36e-04	217	43	5	SM00360
Domain	RRM_dom	TRA2A ZRSR2P1 SRSF10 ZRSR2 U2SURP	1.68e-04	227	43	5	IPR000504
Domain	RRM	TRA2A ZRSR2P1 SRSF10 ZRSR2 U2SURP	1.78e-04	230	43	5	PS50102
Domain	Nucleotide-bd_a/b_plait	TRA2A ZRSR2P1 SRSF10 ZRSR2 U2SURP	3.03e-04	258	43	5	IPR012677
Domain	Bromodomain_CS	BAZ1A ATAD2B	1.62e-03	26	43	2	IPR018359
Domain	-	TRA2A SRSF10 ZRSR2 U2SURP	2.35e-03	244	43	4	3.30.70.330
Domain	BROMODOMAIN_1	BAZ1A ATAD2B	3.28e-03	37	43	2	PS00633
Domain	Bromodomain	BAZ1A ATAD2B	3.45e-03	38	43	2	PF00439
Domain	BROMODOMAIN_2	BAZ1A ATAD2B	4.01e-03	41	43	2	PS50014
Domain	BROMO	BAZ1A ATAD2B	4.20e-03	42	43	2	SM00297
Domain	Bromodomain	BAZ1A ATAD2B	4.20e-03	42	43	2	IPR001487
Domain	-	BAZ1A ATAD2B	4.20e-03	42	43	2	1.20.920.10
Domain	ZnF_C3H1	ZRSR2P1 ZRSR2	5.46e-03	48	43	2	SM00356
Domain	zf-CCCH	ZRSR2P1 ZRSR2	5.69e-03	49	43	2	PF00642
Domain	Znf_CCCH	ZRSR2P1 ZRSR2	7.89e-03	58	43	2	IPR000571
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF419 SRRM1 ZNF133 ZNF561 RORA ZNF492 ZNF721 ZNF773 ZNF562 ZNF626 NUAK1 ZNF718 ZNF875	6.66e-06	1387	33	13	M734
Pathway	WP_MRNA_PROCESSING	SRRM1 ZRSR2P1 SRSF10 SFSWAP ZRSR2 CLK1 BCLAF1 U2SURP	7.08e-06	451	33	8	MM15946
Pathway	REACTOME_MRNA_SPLICING	SRRM1 ZRSR2P1 SRSF10 ZRSR2 U2SURP	9.62e-05	201	33	5	MM15411
Pathway	WP_MRNA_PROCESSING	SRRM1 SRSF10 SFSWAP CLK1	2.04e-04	126	33	4	M39406
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	SRRM1 ZRSR2P1 SRSF10 ZRSR2 U2SURP	4.27e-04	277	33	5	MM15414
Pathway	REACTOME_MRNA_SPLICING	SRRM1 SRSF10 ZRSR2 U2SURP	1.45e-03	212	33	4	M14033
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF419 ZNF561 ZNF721 ZNF562 ZNF91 ZNF626 ZNF718	3.53e-09	181	45	7	37372979
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF721 ZNF91 ZNF626 ZNF718	5.67e-08	29	45	4	14563677
Pubmed	Large-scale identification of mammalian proteins localized to nuclear sub-compartments.	SRRM1 ZRSR2P1 ZRSR2 BAZ1A	1.75e-07	38	45	4	11555636
Pubmed	The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.	TRA2A SRRM1 SRSF10 SFSWAP U2SURP	2.41e-07	104	45	5	31365120
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF419 GLIS3 RORA ZNF721 ZNF773 ZNF91 ZNF626 ZNF718 BAZ1A	7.90e-07	808	45	9	20412781
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	TRA2A SRRM1 SRSF10 FRMD6 CLK1 BCLAF1	9.39e-07	255	45	6	15324660
Pubmed	Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development.	ZRSR2P1 ZRSR2	1.64e-06	2	45	2	35198906
Pubmed	ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.	ZRSR2P1 ZRSR2	1.64e-06	2	45	2	33691379
Pubmed	BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells.	SRSF10 BCLAF1	1.64e-06	2	45	2	25091051
Pubmed	LncRNA H19 Regulates Breast Cancer DNA Damage Response and Sensitivity to PARP Inhibitors via Binding to ILF2.	SRSF10 BCLAF1 U2SURP	3.06e-06	22	45	3	37298108
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ANKRD11 TRA2A SRRM1 SRSF10 XPC SFSWAP MCPH1 BAZ1A BCLAF1 U2SURP	4.77e-06	1294	45	10	30804502
Pubmed	Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.	ZRSR2P1 ZRSR2	4.91e-06	3	45	2	36030305
Pubmed	Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1.	ZRSR2P1 ZRSR2	4.91e-06	3	45	2	8586425
Pubmed	Evaluation of GPR50, hMel-1B, and ROR-alpha melatonin-related receptors and the etiology of adolescent idiopathic scoliosis.	RORA GPR50	4.91e-06	3	45	2	20733416
Pubmed	B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors.	ZNF561 ZNF562	4.91e-06	3	45	2	36717582
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	TRA2A SRRM1 ZRSR2P1 SRSF10 ZRSR2 U2SURP	5.54e-06	347	45	6	16033648
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	TRA2A SRRM1 SRSF10 XPC SFSWAP ZRSR2 CLK1 BCLAF1 U2SURP	8.54e-06	1082	45	9	38697112
Pubmed	Cloning and mapping of the U2af1-rs2 gene with a high transmission distortion in interspecific backcross progeny.	ZRSR2P1 ZRSR2	9.81e-06	4	45	2	7558001
Pubmed	Mouse U2af1-rs1 is a neomorphic imprinted gene.	ZRSR2P1 ZRSR2	9.81e-06	4	45	2	9001233
Pubmed	Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock.	TRA2A SRSF10	9.81e-06	4	45	2	14765198
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	TRA2A SRRM1 SRSF10 XPC SFSWAP BAZ1A BCLAF1 U2SURP	1.16e-05	847	45	8	35850772
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	XRN1 ANKRD11 SRRM1 STOX2 SRSF10 PHACTR2 FRMD6 SH3RF3	1.31e-05	861	45	8	36931259
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	TRA2A ZRSR2P1 XPC SFSWAP BCLAF1	1.82e-05	251	45	5	31076518
Pubmed	Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition.	ZRSR2P1 ZRSR2	2.45e-05	6	45	2	33846634
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ANKRD11 SRRM1 SRSF10 SFSWAP BAZ1A BCLAF1 ATAD2B U2SURP	2.73e-05	954	45	8	36373674
Pubmed	The protein interaction landscape of the human CMGC kinase group.	TRA2A SRRM1 SRSF10 ZRSR2 CLK1 BCLAF1 ZNF875	2.90e-05	695	45	7	23602568
Pubmed	CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins.	CLK1 BCLAF1	3.42e-05	7	45	2	12890497
Pubmed	A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA.	ZRSR2P1 ZRSR2	3.42e-05	7	45	2	9237760
Pubmed	Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy.	ZRSR2P1 ZRSR2	4.56e-05	8	45	2	32371981
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	SRRM1 BAZ1A BCLAF1 U2SURP	5.03e-05	156	45	4	22952844
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF721 ZNF91	7.32e-05	10	45	2	18588511
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	XRN1 SRRM1 SRSF10 XPC PHACTR2 BAZ1A NHSL2 BCLAF1 U2SURP	8.11e-05	1442	45	9	35575683
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF721 ZNF91	8.94e-05	11	45	2	15469996
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	XRN1 TRA2A GPR50 U2SURP	9.14e-05	182	45	4	32239614
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	TRA2A SRRM1 BAZ1A CLK1 BCLAF1	1.02e-04	361	45	5	26167880
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF721 ZNF91	1.27e-04	13	45	2	19850934
Pubmed	A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins).	SRSF10 SFSWAP	1.27e-04	13	45	2	20516191
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	ANKRD11 TRA2A SRRM1 ZNF721 SFSWAP NUAK1 BCLAF1	1.70e-04	922	45	7	27609421
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF721 ZNF91	1.70e-04	15	45	2	15885501
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	TRA2A SRRM1 SRSF10 BAZ1A BCLAF1 U2SURP	1.98e-04	660	45	6	32780723
Pubmed	Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5.	ZRSR2P1 ZRSR2	2.20e-04	17	45	2	7956352
Pubmed	BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing.	SRRM1 SRSF10	2.76e-04	19	45	2	25263594
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	TRA2A SRRM1 SRSF10 SFSWAP BCLAF1 U2SURP	3.00e-04	713	45	6	29802200
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	TRA2A SRRM1 SRSF10 SFSWAP BCLAF1 U2SURP	3.42e-04	731	45	6	29298432
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	ANKRD11 SRRM1 SFSWAP U2SURP	4.06e-04	269	45	4	29511261
Pubmed	SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing.	SRSF10 BCLAF1	5.22e-04	26	45	2	26586428
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	XRN1 TRA2A SRRM1 SRSF10 BCLAF1 U2SURP	5.77e-04	807	45	6	22681889
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	ZRSR2P1 ZRSR2	6.50e-04	29	45	2	32527007
Pubmed	STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells.	CLK1 U2SURP	1.00e-03	36	45	2	33230114
Pubmed	Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells.	TRA2A SRRM1 SRSF10	1.03e-03	153	45	3	28225217
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	SRRM1 SFSWAP BAZ1A BCLAF1 U2SURP	1.08e-03	605	45	5	28977666
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	TRA2A SRRM1 SRSF10 BCLAF1	1.22e-03	361	45	4	30344098
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	SRRM1 SRSF10 BCLAF1	1.24e-03	163	45	3	22113938
Interaction	YWHAG interactions	ANKRD11 TRA2A SRRM1 SLAIN1 STOX2 SRSF10 PHACTR2 FRMD6 NUAK1 BAZ1A NHSL2 CLK1 SH3RF3 BCLAF1 RUBCN	4.11e-08	1248	45	15	int:YWHAG
Interaction	YWHAH interactions	XRN1 ANKRD11 SRRM1 SLAIN1 STOX2 SRSF10 PHACTR2 SFSWAP FRMD6 NUAK1 NHSL2 SH3RF3 RUBCN	5.16e-07	1102	45	13	int:YWHAH
Interaction	DDX23 interactions	ANKRD11 SRRM1 SRSF10 XPC SFSWAP NUAK1 CLK1 BCLAF1 U2SURP	9.47e-07	480	45	9	int:DDX23
Interaction	SRRM4 interactions	SRRM1 ZRSR2P1 ZRSR2 CLK1	1.36e-06	37	45	4	int:SRRM4
Interaction	PNN interactions	TRA2A SRRM1 SRSF10 SFSWAP NUAK1 CLK1 BCLAF1	4.41e-06	302	45	7	int:PNN
Interaction	CLK2 interactions	TRA2A SRRM1 SRSF10 ZRSR2 CLK1 BCLAF1	4.52e-06	195	45	6	int:CLK2
Interaction	CLK1 interactions	TRA2A SRRM1 SRSF10 ZRSR2 CLK1 BCLAF1	8.79e-06	219	45	6	int:CLK1
Interaction	PURG interactions	XRN1 SRRM1 ZNF492 SRSF10 ZNF91 U2SURP	9.75e-06	223	45	6	int:PURG
Interaction	SRPK2 interactions	TRA2A SRRM1 SRSF10 SFSWAP ZRSR2 BAZ1A CLK1 BCLAF1 U2SURP	2.44e-05	717	45	9	int:SRPK2
Interaction	ZRSR2 interactions	ZRSR2P1 ZRSR2 CLK1 U2SURP	2.61e-05	77	45	4	int:ZRSR2
Interaction	NKAPD1 interactions	TRA2A SRRM1 SRSF10 FRMD6 BCLAF1	2.89e-05	161	45	5	int:NKAPD1
Interaction	H19 interactions	SRSF10 BCLAF1 U2SURP	2.93e-05	27	45	3	int:H19
Interaction	TRIM28 interactions	ZNF419 TRA2A ZNF133 ZNF561 ZNF492 ZNF721 SRSF10 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718	6.66e-05	1474	45	12	int:TRIM28
Interaction	U2AF2 interactions	TRA2A SRRM1 ZRSR2P1 SRSF10 ZRSR2 CLK1 BCLAF1 U2SURP	8.51e-05	651	45	8	int:U2AF2
Interaction	SRSF11 interactions	TRA2A SRRM1 SRSF10 CLK1 BCLAF1	8.69e-05	203	45	5	int:SRSF11
Interaction	JMJD6 interactions	ZRSR2P1 SFSWAP FRMD6 ZRSR2 U2SURP	9.10e-05	205	45	5	int:JMJD6
Interaction	GSPT2 interactions	TRA2A SRSF10 BCLAF1 U2SURP	9.46e-05	107	45	4	int:GSPT2
Interaction	TRIM39 interactions	ZNF419 ZNF773 ZNF562 ZNF718	9.81e-05	108	45	4	int:TRIM39
Interaction	SRSF6 interactions	XRN1 TRA2A SRRM1 SRSF10 CLK1 BCLAF1 U2SURP	1.15e-04	503	45	7	int:SRSF6
Interaction	CLK3 interactions	TRA2A SRRM1 SRSF10 CLK1 BCLAF1	1.27e-04	220	45	5	int:CLK3
Interaction	STAG2 interactions	ANKRD11 SRRM1 RORA BAZ1A BCLAF1	1.38e-04	224	45	5	int:STAG2
Interaction	ZRSR2P1 interactions	ZRSR2P1 ZRSR2	1.74e-04	9	45	2	int:ZRSR2P1
Interaction	GPATCH11 interactions	SFSWAP ZRSR2 U2SURP	2.38e-04	54	45	3	int:GPATCH11
Interaction	ZNF561 interactions	ZNF561 ZNF562	2.65e-04	11	45	2	int:ZNF561
Interaction	SRSF7 interactions	TRA2A SRRM1 SRSF10 CLK1 BCLAF1 U2SURP	3.45e-04	425	45	6	int:SRSF7
Interaction	RNPS1 interactions	TRA2A SRRM1 SRSF10 XPC SFSWAP CLK1	3.45e-04	425	45	6	int:RNPS1
Interaction	NUP43 interactions	ANKRD11 SRRM1 SRSF10 XPC BAZ1A BCLAF1 ATAD2B	4.34e-04	625	45	7	int:NUP43
Interaction	MECP2 interactions	TRA2A SRRM1 SRSF10 XPC SFSWAP ZRSR2 BAZ1A CLK1 BCLAF1 U2SURP	4.44e-04	1287	45	10	int:MECP2
Interaction	SRSF4 interactions	TRA2A SRRM1 SRSF10 CLK1 U2SURP	5.30e-04	300	45	5	int:SRSF4
Interaction	SRSF5 interactions	TRA2A SRRM1 SRSF10 ZRSR2 CLK1 U2SURP	6.14e-04	474	45	6	int:SRSF5
Interaction	ZC3H18 interactions	TRA2A SRRM1 SRSF10 SFSWAP NUAK1 CLK1 BCLAF1 U2SURP	6.41e-04	877	45	8	int:ZC3H18
Interaction	PRB3 interactions	NUAK1 CLK1	6.49e-04	17	45	2	int:PRB3
Interaction	MIR429 interactions	XRN1 TRA2A U2SURP	6.53e-04	76	45	3	int:MIR429
Interaction	GRK5 interactions	SRRM1 BAZ1A BCLAF1 U2SURP	7.18e-04	182	45	4	int:GRK5
Interaction	MIR34C interactions	XRN1 TRA2A U2SURP	7.31e-04	79	45	3	int:MIR34C
Interaction	BARD1 interactions	TRA2A SRRM1 SRSF10 BCLAF1 U2SURP	7.41e-04	323	45	5	int:BARD1
Interaction	ZNF562 interactions	ZNF561 ZNF562	8.14e-04	19	45	2	int:ZNF562
Interaction	TRA2A interactions	TRA2A SRRM1 SRSF10 CLK1 U2SURP	8.15e-04	330	45	5	int:TRA2A
Cytoband	19p12	ZNF492 ZNF91 ZNF626	9.74e-05	90	45	3	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF492 ZNF91 ZNF626	2.39e-04	122	45	3	chr19p12
Cytoband	17p13	CD68 ITGAE	5.17e-04	34	45	2	17p13
Cytoband	3q23	XRN1 U2SURP	8.66e-04	44	45	2	3q23
Cytoband	Ensembl 112 genes in cytogenetic band chr3q23	XRN1 U2SURP	1.77e-03	63	45	2	chr3q23
Cytoband	1p36.11	SRRM1 SRSF10	2.05e-03	68	45	2	1p36.11
Cytoband	4p16.3	ZNF721 ZNF718	3.18e-03	85	45	2	4p16.3
Cytoband	19q13.43	ZNF419 ZNF773	3.33e-03	87	45	2	19q13.43
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF419 GLIS3 ZNF133 ZNF561 ZNF492 ZNF721 ZNF773 ZNF562 ZNF91 ZNF626 ZNF718 ZNF875	9.90e-10	718	31	12	28
GeneFamily	RNA binding motif containing	TRA2A ZRSR2P1 SRSF10 ZRSR2 U2SURP	2.87e-05	213	31	5	725
GeneFamily	Zinc fingers CCCH-type	ZRSR2P1 ZRSR2	1.63e-03	35	31	2	73
Coexpression	NAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_3DY_DN	ANKRD11 TRA2A RORA SRSF10 CLK1 BCLAF1 U2SURP	8.32e-06	432	45	7	M41149
Coexpression	DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN	XRN1 TRA2A ZNF561 PHACTR2 FRMD6 NUAK1 CLK1	2.25e-05	504	45	7	M2157
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000	ANKRD11 CD68 SLAIN1 STOX2 GPR50 BAZ1A SH3RF3 BCLAF1 RUBCN ATAD2B	3.14e-05	983	45	10	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	GLIS3 ANKRD11 SRRM1 BAZ1A BCLAF1 U2SURP	4.90e-08	199	45	6	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	XRN1 ANKRD11 SRSF10 CLK1 BCLAF1 ATAD2B	5.05e-08	200	45	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	XRN1 ANKRD11 SRRM1 SRSF10 BCLAF1	1.62e-06	197	45	5	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	GLIS3 RORA FRMD6 NUAK1 NHSL2	1.66e-06	198	45	5	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	ANKRD11 SRRM1 PHACTR2 BAZ1A BCLAF1	1.66e-06	198	45	5	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	XRN1 ANKRD11 SRRM1 SRSF10 BCLAF1	1.66e-06	198	45	5	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	XRN1 ANKRD11 SRRM1 SRSF10 BCLAF1	1.66e-06	198	45	5	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ANKRD11 RORA SRSF10 CLK1 ATAD2B	1.70e-06	199	45	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-pre_B_progenitor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ANKRD11 TRA2A SRRM1 SRSF10 ITGAE	1.70e-06	199	45	5	dd94e42b62af7cbd69c472681d3c758552694ae2
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	ANKRD11 SRRM1 PHACTR2 BCLAF1 U2SURP	1.70e-06	199	45	5	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	(05)_Secretory-(2)_GFP_FOXI1\|(05)_Secretory / shred by cell type by condition	ANKRD11 SRRM1 PHACTR2 BAZ1A BCLAF1	1.70e-06	199	45	5	d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell	(04)_Interm._basal>secr.-(2)_GFP_FOXI1\|(04)_Interm._basal>secr. / shred by cell type by condition	ANKRD11 SRRM1 PHACTR2 BAZ1A BCLAF1	1.70e-06	199	45	5	53ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell	lymphoid-NK_cell-NK_cell\|NK_cell / Lineage, cell class and subclass	XRN1 ANKRD11 SRRM1 RORA CLK1	1.70e-06	199	45	5	945fbf5845403a8b22d04963f50ad69c414b6153
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF419 ITGAE ZNF626 ZNF875	2.54e-05	169	45	4	8caf7996796a2e2716e3855de855c903d6126bf2
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XRN1 ANKRD11 SRRM1 BCLAF1	3.11e-05	178	45	4	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD11 SRRM1 BAZ1A CLK1	3.77e-05	187	45	4	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	RORA FRMD6 NHSL2 SH3RF3	4.01e-05	190	45	4	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XRN1 RORA FRMD6 BCLAF1	4.09e-05	191	45	4	7d1595e616f6f111fc2f5bc1b179c5d67d624cc9
ToppCell	control-Lymphoid-CTL\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	XRN1 RORA ITGAE BCLAF1	4.26e-05	193	45	4	89d407a88b5956559a589425b89b3eb8dc78e1dd
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	RORA FRMD6 NHSL2 SH3RF3	4.35e-05	194	45	4	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	COPD-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	GLIS3 RORA STOX2 FRMD6	4.44e-05	195	45	4	e91ce548ae7224661ee5d2f2639794a5f69798ee
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XRN1 IGSF10 RORA BCLAF1	4.44e-05	195	45	4	5c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D122\|Adult / Lineage, Cell type, age group and donor	IGSF10 RORA NUAK1 NHSL2	4.44e-05	195	45	4	aa0add081881d349099d12efca5cdee098038d4e
ToppCell	COVID-19_Severe-PLT_4\|World / Disease Group and Platelet Clusters	TRA2A SRRM1 SRSF10 CLK1	4.53e-05	196	45	4	ad43efdd4d73b6615f65f06a315b33576e317473
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	IGSF10 RORA NUAK1 NHSL2	4.53e-05	196	45	4	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	GLIS3 RORA FRMD6 NHSL2	4.62e-05	197	45	4	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	XRN1 ANKRD11 RORA SRSF10	4.62e-05	197	45	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	GLIS3 RORA FRMD6 NHSL2	4.62e-05	197	45	4	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	COVID-19_Severe-PLT_4\|COVID-19_Severe / Disease Group and Platelet Clusters	TRA2A SRRM1 SRSF10 CLK1	4.71e-05	198	45	4	abfddbee99ef8c7719e6e6f62571e9be030e4acf
ToppCell	Sepsis-URO-Lymphocyte-T/NK-MAIT\|URO / Disease, condition lineage and cell class	ZNF419 IGSF10 RORA LRRC37A	4.71e-05	198	45	4	75db638278d4be2b0f406cd8871058a8352c5a86
ToppCell	COVID-19_Mild-PLT_4\|COVID-19_Mild / Disease Group and Platelet Clusters	TRA2A SRRM1 SRSF10 CLK1	4.71e-05	198	45	4	3d8c33dba759df0974aeb2b9a6b5167ae7a18e1f
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	GLIS3 ANKRD11 BAZ1A BCLAF1	4.80e-05	199	45	4	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	megakaryocytic-CD34+_Megakaryoblast\|megakaryocytic / Lineage and Cell class	IGSF10 SRSF10 BCLAF1 U2SURP	4.80e-05	199	45	4	99a65887d3c8a2cde26693dd74404b101bba9d58
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	XRN1 ANKRD11 SRSF10 BCLAF1	4.89e-05	200	45	4	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	ZNF419 CD68 FRMD6 SH3RF3	4.89e-05	200	45	4	be1abe5bb1ce4e7dfec63af4ed0fc5b96bf77866
Computational	Neighborhood of HDAC1	TRA2A SRRM1 SRSF10 U2SURP	1.11e-04	110	25	4	GNF2_HDAC1
Disease	phosphatidylethanolamine measurement	RORA PHACTR2 BAZ1A RAB3IL1	8.00e-05	173	39	4	EFO_0010228
Disease	kidney cancer	RORA MCPH1	9.29e-05	11	39	2	MONDO_0002367
Disease	Autism Spectrum Disorders	ANKRD11 GPR50 SFSWAP	1.96e-04	85	39	3	C1510586
Disease	Seasonal Affective Disorder	RORA GPR50	2.02e-04	16	39	2	C0085159
Disease	alanine measurement	GLIS3 RORA MCPH1	2.02e-04	86	39	3	EFO_0009765
Disease	cortical thickness	GLIS3 CD68 RORA MCPH1 NUAK1 BAZ1A SH3RF3	5.69e-04	1113	39	7	EFO_0004840
Disease	brain measurement, neuroimaging measurement	GLIS3 RORA PIGF NUAK1 SH3RF3	7.54e-04	550	39	5	EFO_0004346, EFO_0004464
Disease	coffee consumption measurement, tea consumption measurement	XRN1 RORA	1.55e-03	44	39	2	EFO_0006781, EFO_0010091
Disease	cortical surface area measurement	XRN1 GLIS3 RORA MCPH1 NUAK1 SH3RF3 ATAD2B	1.72e-03	1345	39	7	EFO_0010736
Disease	birth weight	XRN1 RORA MCPH1 ATAD2B	1.86e-03	399	39	4	EFO_0004344
Disease	neuroimaging measurement	GLIS3 RORA MCPH1 NUAK1 BAZ1A SH3RF3	2.61e-03	1069	39	6	EFO_0004346
Disease	cortical surface area measurement, neuroimaging measurement	RORA NUAK1 SH3RF3	3.35e-03	227	39	3	EFO_0004346, EFO_0010736
Disease	non-small cell lung carcinoma	PHACTR2 BAZ1A	4.44e-03	75	39	2	EFO_0003060
Disease	intraocular pressure measurement	GLIS3 RORA STOX2 MCPH1	4.46e-03	509	39	4	EFO_0004695

Protein segments in the cluster

Peptide	Gene	Start	Entry
RHSSSSSKKSHDRER	ANKRD11	1351	Q6UB99
TKSLRIASRSTRHSH	BAZ1A	1326	Q9NRL2
SSHKRRKRSHSSAQE	CLK1	26	P49759
RKGHSRHKSTSSTLC	RAB3IL1	186	Q8TBN0
TGTTSHRTTKSHKTT	CD68	46	P34810
HRTTKSHKTTTHRTT	CD68	51	P34810
SSSVKRKRVSHGSHS	MCPH1	351	Q8NEM0
RFHKTRSHVTHRTTK	LRRC37A	1306	A6NMS7
RRKKHAIHSSDTTSS	ATAD2B	326	Q9ULI0
RSSSAYRKSASTHHK	GPR50	391	Q13585
SIFTSSHGSRRKASK	ITGAE	291	P38570
TTREAAGSSHSKKTT	PHACTR2	216	O75167
SSAGSMKHKRLSRHS	FRMD6	371	Q96NE9
AEVGKHTSSTSKRHN	IGSF10	706	Q6WRI0
KHKREQDHSRSSSSS	BCLAF1	741	Q9NYF8
PRHSSTRSHSARSKK	GLIS3	131	Q8NEA6
TVTSGAKKSHIRSHS	RUBCN	396	Q92622
KRHGSSRKSSTHSST	GARIN3	491	Q8TC56
SPKYHSSSKSRSRSH	SFSWAP	771	Q12872
RSRSHSKAKHSLPSA	SFSWAP	781	Q12872
RSKTKVSRHHSETNF	NHSL2	791	Q5HYW2
TSSKRSSLSHKVTGF	PIGF	66	Q07326
VSRHSSSVSLSSGKK	SLAIN1	296	Q8ND83
LKKRSNSEHRSHSTG	NUAK1	401	O60285
HKESSRSRSSHKDSP	U2SURP	961	O15042
TFITSSRRSKHLKTH	ZNF561	401	Q8N587
TSSHRSKHLKTHSGE	ZNF562	411	Q6V9R5
TTSSDFAKHKRIHTG	ZNF718	321	Q3SXZ3
KERSHSHSRSSSKER	SRRM5	361	B3KS81
RSRSASHTKTRGTSK	SRSF10	196	O75494
SSTSRGISVTKKTHT	RORA	51	P35398
TKKRHSFTALSVTHR	SH3RF3	376	Q8TEJ3
AHHSGRSKKSRTHRK	STOX2	351	Q9P2F5
RTHRKSHGKSRSHSK	STOX2	361	Q9P2F5
SHGKSRSHSKTRVSK	STOX2	366	Q9P2F5
LSSKHRKGSSPSRST	SRRM1	656	Q8IYB3
SRSPSRVSKHSESHS	TRA2A	36	Q13595
RVSKHSESHSRSRSK	TRA2A	41	Q13595
ISSSSSFAKHKRIHT	ZNF721	246	Q8TF20
TSSSSFAKHKRIHTG	ZNF721	471	Q8TF20
SISHHKSTPISSSRR	XRN1	1676	Q8IZH2
QVTHTGEKSHRSSKS	ZNF773	166	Q6PK81
SSTLTTHKRNHTGEK	ZNF626	241	Q68DY1
SLKSHLSRHRKTTSV	ZNF133	616	P52736
SNSNRHTIRHTGKKS	ZNF492	126	Q9P255
SKAFSRFSHLTTHKR	ZNF492	371	Q9P255
FSRSSTLAKHKRIHT	ZNF91	331	Q05481
AFSRSSTLTKHKTIH	ZNF91	806	Q05481
SSTLTRHTRMHTGEK	ZNF91	1006	Q05481
RSSPSRAASHSSHKR	nan	236	A8MUI8
KSHKRTSKSRERHNS	ZRSR2P1	411	Q15695
FTRKSTLSTHQRTHS	ZNF875	506	P10072
TKAGSKSASRTHRGS	XPC	476	Q01831
HTGEKSHRSSKSREA	ZNF419	181	Q96HQ0
KSHKRTSKSRERHNS	ZRSR2	406	Q15696