Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	sperm cytoplasmic droplet	ROPN1B ROPN1	6.04e-05	5	52	2	GO:0097598
Domain	cAMP_dep_PK_reg_su_I/II_a/b	ROPN1B ROPN1	7.80e-04	15	52	2	IPR003117
Domain	Aminotransferase_I/II	ALAS2 ACCSL	1.01e-03	17	52	2	IPR004839
Domain	Aminotran_1_2	ALAS2 ACCSL	1.01e-03	17	52	2	PF00155
Domain	-	ALAS2 ACCSL	4.27e-03	35	52	2	3.90.1150.10
Domain	PyrdxlP-dep_Trfase_major_sub2	ALAS2 ACCSL	4.51e-03	36	52	2	IPR015422
Domain	-	ALAS2 ACCSL	5.27e-03	39	52	2	3.40.640.10
Domain	PyrdxlP-dep_Trfase	ALAS2 ACCSL	5.82e-03	41	52	2	IPR015424
Domain	PyrdxlP-dep_Trfase_major_sub1	ALAS2 ACCSL	5.82e-03	41	52	2	IPR015421
Domain	ABC_transporter_CS	ABCC3 ABCA12	6.10e-03	42	52	2	IPR017871
Domain	AAA+_ATPase	ABCC3 ABCA12 NAIP	7.53e-03	144	52	3	IPR003593
Domain	AAA	ABCC3 ABCA12 NAIP	7.53e-03	144	52	3	SM00382
Domain	ER_TARGET	FOXRED2 PDILT	7.59e-03	47	52	2	PS00014
Domain	ABC_tran	ABCC3 ABCA12	7.90e-03	48	52	2	PF00005
Domain	ABC_TRANSPORTER_2	ABCC3 ABCA12	7.90e-03	48	52	2	PS50893
Domain	ABC_TRANSPORTER_1	ABCC3 ABCA12	8.22e-03	49	52	2	PS00211
Domain	ABC_transporter-like	ABCC3 ABCA12	8.55e-03	50	52	2	IPR003439
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABCC3 NCOR1 SEPHS2 THADA TMEM259 MFHAS1 CSPG4 KCNH3 SPATA13 BAHCC1	5.67e-06	1105	53	10	35748872
Pubmed	Loss of ASP but not ROPN1 reduces mammalian ciliary motility.	ROPN1B ROPN1	6.83e-06	3	53	2	22021175
Pubmed	Loss of R2D2 proteins ROPN1 and ROPN1L causes defects in murine sperm motility, phosphorylation, and fibrous sheath integrity.	ROPN1B ROPN1	6.83e-06	3	53	2	23303679
Pubmed	Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella.	ROPN1B ROPN1	1.36e-05	4	53	2	10591629
Pubmed	FSCB phosphorylation regulates mouse spermatozoa capacitation through suppressing SUMOylation of ROPN1/ROPN1L.	ROPN1B ROPN1	1.36e-05	4	53	2	27398160
Pubmed	CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath.	ROPN1B ROPN1	2.27e-05	5	53	2	20731842
Pubmed	Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.	NCOR1 CSPG4	3.40e-05	6	53	2	18829436
Pubmed	Nuclear receptor corepressors Ncor1 and Ncor2 (Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis.	NCOR1 FGF8	3.40e-05	6	53	2	27506116
Pubmed	Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA.	ROPN1B ROPN1	3.40e-05	6	53	2	11278869
Pubmed	High throughput RNAi screening identifies ID1 as a synthetic sick/lethal gene interacting with the common TP53 mutation R175H.	THADA ABCA12 NUP98	5.86e-05	49	53	3	24378760
Pubmed	Interaction between axons and specific populations of surrounding cells is indispensable for collateral formation in the mammillary system.	ARX CNR1	6.34e-05	8	53	2	21625468
Pubmed	FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis.	ROPN1B ROPN1	8.15e-05	9	53	2	17855365
Pubmed	CFAP61 is required for sperm flagellum formation and male fertility in human and mouse.	ROPN1B ROPN1	1.02e-04	10	53	2	34792097
Pubmed	FGF8 signaling patterns the telencephalic midline by regulating putative key factors of midline development.	MEST FGF8	1.24e-04	11	53	2	18547559
Pubmed	Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling.	CSPG4 CNR1	1.24e-04	11	53	2	25030704
Pubmed	Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation.	NEO1 CSPG4	1.49e-04	12	53	2	31336386
Pubmed	Cell surface heparan sulfate chains regulate local reception of FGF signaling in the mouse embryo.	CSPG4 FGF8	1.76e-04	13	53	2	21839920
Pubmed	Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization.	MEST PXDN SPATA13	2.01e-04	74	53	3	15031102
Pubmed	Identification and characterization of VPO1, a new animal heme-containing peroxidase.	PXDN FGF8	2.70e-04	16	53	2	18929642
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	NCOR1 SEPHS2 PXDN CSPG4 NUP98 SLC44A2 ALAS2 SPATA13 BAHCC1	3.01e-04	1442	53	9	35575683
Pubmed	A perivascular niche for multipotent progenitors in the fetal testis.	CSPG4 ARX	3.05e-04	17	53	2	30375389
Pubmed	Fgf8 controls regional identity in the developing thalamus.	ARX FGF8	3.05e-04	17	53	2	18653561
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	ABCC3 NEO1 ABCA12 BTN1A1	3.22e-04	214	53	4	22199357
Pubmed	The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development.	FGF8 ALAS2	3.43e-04	18	53	2	20347762
Pubmed	Development of head organizer of the mouse embryo depends on a high level of mitochondrial metabolism.	LIAS FGF8	3.83e-04	19	53	2	20450902
Pubmed	Fgf15 regulates thalamic development by controlling the expression of proneural genes.	ARX FGF8	3.83e-04	19	53	2	26311466
Pubmed	Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.	CSPG4 ARX	4.25e-04	20	53	2	36551904
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	MEST ABCC3 THADA FOXRED2 PXDN TMEM259 CSPG4 UST	4.40e-04	1201	53	8	35696571
Pubmed	Stromal netrin 1 coordinates renal arteriogenesis and mural cell differentiation.	NEO1 CSPG4	5.16e-04	22	53	2	37823339
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCC3 ABCA12	5.16e-04	22	53	2	8894702
Pubmed	Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex.	NEO1 CSPG4	5.65e-04	23	53	2	26659141
Pubmed	Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.	GPR137B FGF8	5.65e-04	23	53	2	14623818
Pubmed	Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times.	MEST FGF8	6.16e-04	24	53	2	20237272
Pubmed	FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development.	MEST FGF8	6.68e-04	25	53	2	18625063
Pubmed	Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.	ARX CNR1	6.68e-04	25	53	2	31665922
Pubmed	Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development.	FMNL3 FGF8	7.23e-04	26	53	2	18331719
Pubmed	Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors.	ARX FGF8	9.64e-04	30	53	2	21880902
Pubmed	Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects.	NEO1 FGF8	9.64e-04	30	53	2	38404688
Pubmed	Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm.	TRAF2 FGF8	1.10e-03	32	53	2	19500387
Pubmed	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.	CLIP4 FOXRED2 NUP98 SLC44A2	1.11e-03	298	53	4	32353859
Pubmed	Gene expression profiling in the developing secondary palate in the absence of Tbx1 function.	FGF8 ALAS2	1.24e-03	34	53	2	29866044
Pubmed	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.	CSPG4 UST	1.47e-03	37	53	2	32201365
ToppCell	10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-pDC_progenitor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	MEST C1QTNF4 GRIK5 KCNH3 CYB561	1.00e-06	151	53	5	8ffd71d847fe1aeebe7f43c4b6ca73efb19d6041
ToppCell	Control-Non-classical_Monocyte-\|Control / Disease condition and Cell class	CLIP4 ABCC3 RGS19 SLC44A2 GPR137B	3.61e-06	196	53	5	b17ab094cdc7050c2997e24ed474779b5d6f6146
ToppCell	Control-Non-classical_Monocyte\|Control / Disease condition and Cell class	CLIP4 ABCC3 RGS19 SLC44A2 GPR137B	3.61e-06	196	53	5	404064ccfe2cb73df7a7f88aa65d86b97dcef9d4
ToppCell	TCGA-Skin\|World / Sample_Type by Project: Shred V9	CSPG4 ROPN1B ACCSL ROPN1	2.34e-05	140	53	4	57d9979bfdcb695869690bf62fa80759ad06eb6c
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nxph3-Excitatory_Neuron.Slc17a7-Slc17a6.Nxph3-Cbln2-Kcnh8_(Deep_layer_subiculum)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	STPG3 ABCA12 ROPN1	3.88e-05	55	53	3	5ce0008811bb696191923de9b34ea6e0d8d39a7a
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma\|TCGA-Endometrium / Sample_Type by Project: Shred V9	SPON1 GLIS2 SLC44A2 GRIK5	4.34e-05	164	53	4	08c725548e751f815b4df778607270498204b353
ToppCell	COVID-19-Heart-Adipocyte\|Heart / Disease (COVID-19 only), tissue and cell type	CLIP4 MEST PXDN CNR1	4.87e-05	169	53	4	bd39f85b48207955f80ca120a11e15a0124117b9
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_Erythro-Mega\|lymph-node_spleen / Manually curated celltypes from each tissue	ABCC3 ALAS2 ACCSL NMU	5.58e-05	175	53	4	5ca3369ce2c2bb88ba097260195aecd67cec1a3a
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|390C / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 PXDN SPON1 GLIS2	5.71e-05	176	53	4	852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 PXDN SPON1 GLIS2	5.71e-05	176	53	4	d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCell	IIH-CD8-CD4_Treg\|IIH / Condition, Cell_class and T cell subcluster	NEO1 SPON1 GPR137B ANKMY1	6.23e-05	180	53	4	d1a8b25115c80e5a5bd0b8244167a98250ab9778
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Dendritic_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIAS NEO1 SPON1 XKRX	6.23e-05	180	53	4	710526abedc8e0f9ba19ad69220df4c9468ada8f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_KLHL14\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPON1 ARX SPATA13 NMU	6.64e-05	183	53	4	439b1d1373b7cc73d65f3b59037a6def7cf8f4ba
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CLIP4 SPON1 ASPSCR1 UST	7.22e-05	187	53	4	387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCell	droplet-Lung-nan-18m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 PXDN GLIS2 CYB561	8.32e-05	194	53	4	f35f03412b596b6b570b377ba1a607409d984bb1
ToppCell	(0)_Myeloid-(00)_Monocyte-(001)_CD16+_Monocyte\|(00)_Monocyte / immune cells in Peripheral Blood (logTPM normalization)	ABCC3 RGS19 SLC44A2 GPR137B	8.32e-05	194	53	4	89cb262e04d7105012e957e0add44c73de6c1ed0
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Neuronal-Cortical_hem\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	MEST ARX FGF8 NMU	8.32e-05	194	53	4	6f32422e1c079a2fbf0ab568e6cb8365fd627d9a
ToppCell	BLOOD--(3)_MNP-(3)_Non_classical_monocytes\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ABCC3 RGS19 SLC44A2 GPR137B	8.32e-05	194	53	4	f80433c7dd7590ca8c49630d2cd018b63438fd92
ToppCell	myeloid-CD16+_Monocyte\|myeloid / Lineage and Cell class	ABCC3 RGS19 SLC44A2 GPR137B	8.32e-05	194	53	4	aeeadfeb01827dbc7de6576c76fb2e41a3c59247
ToppCell	(0)_Myeloid-(001)_CD16+_Monocyte\|(0)_Myeloid / immune cells in Peripheral Blood (logTPM normalization)	ABCC3 RGS19 SLC44A2 GPR137B	8.32e-05	194	53	4	4240d0b3cf264f51dcf0cb4d0a18641d85d38638
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MEST PXDN SPON1 CNR1	9.00e-05	198	53	4	12cd9f0bbad8dce5199ebfed1c4a8080710ca055
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-GXYLT2-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SPON1 ARX SPATA13 NMU	9.36e-05	200	53	4	fe63aa1febd2bf650a7dd4e8b4420063580644ba
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-GXYLT2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SPON1 ARX SPATA13 NMU	9.36e-05	200	53	4	37728d83b246dd70933d1f52f938bc1c401df7b9
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-GXYLT2--L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SPON1 ARX SPATA13 NMU	9.36e-05	200	53	4	cafa1b46d0b052fca6191ad99d5862a07d0a1fd2
Disease	bilirubin metabolic disorder (biomarker_via_orthology)	ABCC3 ALAS2	5.88e-05	7	50	2	DOID:2741 (biomarker_via_orthology)
Disease	non-syndromic X-linked intellectual disability (implicated_via_orthology)	THADA ARX	1.01e-04	9	50	2	DOID:0050776 (implicated_via_orthology)
Disease	sphingomyelin 14:0 measurement	THADA GPR137B	3.77e-04	17	50	2	EFO_0010390
Disease	renal system measurement	PDILT GRIK5	5.24e-04	20	50	2	EFO_0004742
Disease	phosphatidylserines measurement	ASPSCR1 GRIK5	6.96e-04	23	50	2	EFO_0020049
Disease	parental emotion expression measurmement, conduct disorder	MFHAS1 CNR1	8.23e-04	25	50	2	EFO_0004216, EFO_0008342
Disease	response to perphenazine	FMNL3 PXDN	8.91e-04	26	50	2	GO_0097334
Disease	cardiovascular disease	THADA PDILT C1QTNF4 BAHCC1 CYB561	1.04e-03	457	50	5	EFO_0000319
Disease	mean arterial pressure	THADA RGS19 PDILT BAHCC1 CYB561	1.54e-03	499	50	5	EFO_0006340
Disease	right ventricular systolic volume measurement	FMNL3 SPON1	1.62e-03	35	50	2	EFO_0021815
Disease	glaucoma	PNPT1 GRIK5 UST	2.28e-03	154	50	3	MONDO_0005041
Disease	left ventricular systolic function measurement	PXDN SPON1	2.54e-03	44	50	2	EFO_0008206
Disease	Endometrioma	NCOR1 UST CNR1	2.59e-03	161	50	3	C0269102
Disease	Endometriosis	NCOR1 UST CNR1	2.59e-03	161	50	3	C0014175

Protein segments in the cluster

Peptide	Gene	Start	Entry
LVPAPFYGGFAFSSR	ACCSL	261	Q4AC99
FTAQRLRPFYRFLSP	NAIP	731	Q13075
LRPFYRFLSPAFQEF	NAIP	736	Q13075
PGYPRFSGSLASTFL	BAHCC1	121	Q9P281
LFPDRYVLQGFFRPS	ASPSCR1	396	Q9BZE9
DTFRFRVTAPPYFSP	CSPG4	871	Q6UVK1
TFSNVTFSGPLRPFF	BTN1A1	446	Q13410
YLAPRNLPSTGFFPF	ABCA12	56	Q86UK0
PGAYFFSFTLGKLPR	C1QTNF4	226	Q9BXJ3
LFGRYPFIFSASDTP	CLIP4	16	Q8N3C7
SFFLFPGASFSLRSR	CYB561	141	P49447
PYPETSAGFLSRLFF	ABCC3	206	O15438
SLALYPEFAPRFSRG	KCNH3	681	Q9ULD8
NSLTYSPFGDSPLFR	NUP98	506	P52948
TSYNRFRKFPFFTRP	KCNK18	161	Q7Z418
PFASQSRGYFLFRPR	NMU	151	P48645
FPFTFPLGLFARYSV	MFHAS1	886	Q9Y4C4
FGPGIFIYTRPFRAF	OR4N2	251	Q8NGD1
VFGRYFCSPVRPLSS	LIAS	16	O43766
RYLDGVPSSFQFFLP	GLIS2	121	Q9BZE0
YAVFERAPRPGSFFT	FOXRED2	56	Q8IWF2
RSYAAGFIFTTSLPP	ALAS2	411	P22557
SLRFEFLNYPPFTRS	FGF8	206	P55075
FLNYPPFTRSLRGSQ	FGF8	211	P55075
PSVFFPVFVRFIRSY	FMNL3	911	Q8IVF7
SGFSLLRYPEFSSFI	ANKMY1	111	Q9P2S6
LGYFPQKFPLTSFRG	CNR1	41	P21554
GVSAYLSRPSPFDLF	IGHE	216	P01854
YSRLFPPAFRRLFEF	TMEM259	56	Q4ZIN3
FRHPAFISPAFGRLF	ARX	471	Q96QS3
PAFPLFSAFGRALRY	SLC44A2	486	Q8IWA5
RKPGYFSFLDPFSPA	GRIK5	531	Q16478
FVFSRGLTPVFGPYT	MEST	211	Q5EB52
YLDRYPFFRLFPSGS	PDILT	456	Q8N807
HGFSPRSYFFDNPRR	GPR137B	331	O60478
DSYPRFLSSPTYRAL	RGS19	191	P49795
GGLPRIPFSTFQFLY	ROPN1B	151	Q9BZX4
TLSAAPPSYFRGFTL	SPON1	81	Q9HCB6
TGREFFSRFPELYPF	THADA	1281	Q6YHU6
LFFTRPSGSYFIRLL	SLC6A16	551	Q9GZN6
DARSPGSISYLPSFF	NCOR1	2181	O75376
QSPGASIRTFTPFYF	NEO1	41	Q92859
RSIRPLFPAGYFYDT	PNPT1	136	Q8TCS8
LGARPFRFSFFPDLL	CLRN1	76	P58418
PPYKAVSARFRPFTF	SPATA13	61	Q96N96
GRIPAIFSPAFYTSR	TRAF2	371	Q12933
PLLPFLRFSLRDYGF	UST	36	Q9Y2C2
IFRFSSLHSYPFPGT	STK19	91	P49842
SFLSRIFYFPLRPFI	TRIM77	431	I1YAP6
LTLGRSFSNYRPFEP	SEPHS2	26	Q99611
YQLLSRPAFPAFSFR	STPG3	171	Q8N7X2
GGSPRIPFSTFQFLY	ROPN1	151	Q9HAT0
VTLRYFGSPARPTFV	PXDN	331	Q92626
SRLLRFTYGPSFPAF	RALGAPB	246	Q86X10
GANPRFTFPFSILFS	XKRX	26	Q6PP77
FSRVPLFPVFDLSYF	TMEM38A	16	Q9H6F2