Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncytoskeleton-nuclear membrane anchor activity

SYNE1 SYNE2

9.43e-055622GO:0140444
GeneOntologyCellularComponentnuclear protein-containing complex

TRERF1 NCOA2 EXOSC10 SATB2 PMS2 KMT2D ERCC5 EP400 POLD1 SYNE1 ARID2 SYNE2 YY1AP1 TEX10

3.96e-0513776214GO:0140513
GeneOntologyCellularComponentmicrotubule organizing center attachment site

SYNE1 SYNE2

4.68e-0411622GO:0034992
GeneOntologyCellularComponentmeiotic nuclear membrane microtubule tethering complex

SYNE1 SYNE2

4.68e-0411622GO:0034993
GeneOntologyCellularComponentnuclear membrane protein complex

SYNE1 SYNE2

4.68e-0411622GO:0106083
GeneOntologyCellularComponentnuclear membrane microtubule tethering complex

SYNE1 SYNE2

4.68e-0411622GO:0106094
GeneOntologyCellularComponentlamellipodium

IGF2BP1 SSH1 ITSN1 SYNE2 DMD

6.00e-04230625GO:0030027
GeneOntologyCellularComponentnucleotide-excision repair complex

ERCC5 POLD1

6.61e-0413622GO:0000109
GeneOntologyCellularComponentdendritic spine

NCOA2 IGF2BP1 SYNE1 ITSN1 DNM3

7.54e-04242625GO:0043197
GeneOntologyCellularComponentneuron spine

NCOA2 IGF2BP1 SYNE1 ITSN1 DNM3

8.27e-04247625GO:0044309
GeneOntologyCellularComponentdendritic spine head

SYNE1 DNM3

1.01e-0316622GO:0044327
GeneOntologyCellularComponentnuclear body

MSANTD1 NCOA2 NUGGC EP400 POLDIP3 YLPM1 ZFHX3 YY1AP1 MAML2

1.31e-03903629GO:0016604
GeneOntologyCellularComponentfilopodium membrane

SYNE2 DMD

1.75e-0321622GO:0031527
GeneOntologyCellularComponenthistone deacetylase complex

TRERF1 SATB2 EP400

2.06e-0385623GO:0000118
GeneOntologyCellularComponentnuclear replisome

ERCC5 POLD1

2.10e-0323622GO:0043601
GeneOntologyCellularComponentreplisome

ERCC5 POLD1

2.48e-0325622GO:0030894
GeneOntologyCellularComponentSWI/SNF superfamily-type complex

EP400 ARID2 YY1AP1

2.92e-0396623GO:0070603
GeneOntologyCellularComponentINO80-type complex

EP400 YY1AP1

3.11e-0328622GO:0097346
HumanPhenoAbnormal cardiac ventricle morphology

UBR1 SATB2 PMS2 KMT2D ODAD1 POLD1 SYNE1 ARID2 ADAMTS17 LAMA4 YY1AP1 DMD MYRF

1.42e-067802113HP:0001713
HumanPhenoOligodontia

UBR1 SATB2 KMT2D IKBKG HUWE1

5.03e-0665215HP:0000677
HumanPhenoScimitar anomaly

KMT2D MYRF

9.67e-054212HP:0011626
HumanPhenoAbnormal ventricular septum morphology

UBR1 SATB2 KMT2D ODAD1 SYNE1 ARID2 ADAMTS17 YY1AP1 MYRF

1.09e-04521219HP:0010438
HumanPhenoLipodystrophy

POLD1 SYNE1 SYNE2 LAMA4 DMD

1.31e-04127215HP:0009125
HumanPhenoAbnormal joint physiology

UBR1 SATB2 PMS2 KMT2D ERCC5 POLD1 SYNE1 ARID2 SYNE2 ADAMTS17 BBIP1 IKBKG HUWE1 DMD

1.41e-0413582114HP:0034430
HumanPhenoAbnormality of joint mobility

UBR1 SATB2 PMS2 KMT2D ERCC5 POLD1 SYNE1 ARID2 SYNE2 ADAMTS17 BBIP1 IKBKG HUWE1 DMD

1.41e-0413582114HP:0011729
DomainActinin_actin-bd_CS

SPTBN5 SYNE1 SYNE2 DMD

8.70e-0723614IPR001589
DomainSpectrin

SPTBN5 SYNE1 SYNE2 DMD

8.70e-0723614PF00435
DomainACTININ_2

SPTBN5 SYNE1 SYNE2 DMD

8.70e-0723614PS00020
DomainACTININ_1

SPTBN5 SYNE1 SYNE2 DMD

8.70e-0723614PS00019
DomainSpectrin_repeat

SPTBN5 SYNE1 SYNE2 DMD

2.30e-0629614IPR002017
DomainSpectrin/alpha-actinin

SPTBN5 SYNE1 SYNE2 DMD

3.46e-0632614IPR018159
DomainSPEC

SPTBN5 SYNE1 SYNE2 DMD

3.46e-0632614SM00150
DomainCH

SPTBN5 SYNE1 SYNE2 DMD

6.01e-0565614SM00033
DomainKASH

SYNE1 SYNE2

6.27e-054612PF10541
DomainKASH

SYNE1 SYNE2

6.27e-054612IPR012315
DomainKASH

SYNE1 SYNE2

6.27e-054612PS51049
DomainKASH

SYNE1 SYNE2

6.27e-054612SM01249
DomainCH

SPTBN5 SYNE1 SYNE2 DMD

8.04e-0570614PF00307
Domain-

SPTBN5 SYNE1 SYNE2 DMD

8.50e-05716141.10.418.10
DomainCH

SPTBN5 SYNE1 SYNE2 DMD

9.47e-0573614PS50021
DomainCH-domain

SPTBN5 SYNE1 SYNE2 DMD

1.05e-0475614IPR001715
Domain-

EXOSC10 REXO5 POLD1

4.85e-04476133.30.420.10
DomainDynamin_GTPase

NUGGC DNM3

1.07e-0315612IPR001401
DomainDynamin_N

NUGGC DNM3

1.07e-0315612PF00350
DomainDynamin_SF

NUGGC DNM3

1.07e-0315612IPR022812
DomainRNaseH-like_dom

EXOSC10 REXO5 POLD1

1.49e-0369613IPR012337
DomainTyr_Pase_AS

PTPRE PTPRG SSH1

1.75e-0373613IPR016130
DomainTYR_PHOSPHATASE_1

PTPRE PTPRG SSH1

2.80e-0386613PS00383
DomainTYR_PHOSPHATASE_2

PTPRE PTPRG SSH1

2.89e-0387613PS50056
DomainTYR_PHOSPHATASE_dom

PTPRE PTPRG SSH1

2.89e-0387613IPR000387
Domain-

PTPRE PTPRG SSH1

3.39e-03926133.90.190.10
DomainProt-tyrosine_phosphatase-like

PTPRE PTPRG SSH1

4.16e-0399613IPR029021
DomainHomeodomain-like

TRERF1 SATB2 SSH1 EP400 ZFHX3

4.54e-03332615IPR009057
DomainRRM_1

IGF2BP1 REXO5 POLDIP3 ENOX2

4.75e-03208614PF00076
DomainRRM

IGF2BP1 REXO5 POLDIP3 ENOX2

5.52e-03217614SM00360
DomainPTPc

PTPRE PTPRG

6.15e-0336612SM00194
DomainRRM_dom

IGF2BP1 REXO5 POLDIP3 ENOX2

6.45e-03227614IPR000504
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PMS2 KMT2D PTPRE PTPRG SSH1 TBC1D5 SYNE2 YLPM1 CPD HUWE1 DMD TEX10 FAM27E3

4.11e-081049631327880917
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TRERF1 NCOA2 MAGI1 SSH1 SYNE1 TBC1D5 ITSN1 SYNE2 YLPM1 DNM3 HUWE1 TEX10

1.38e-07963631228671696
Pubmed

Human transcription factor protein interaction networks.

TRERF1 NCOA2 SATB2 IGF2BP1 KMT2D EP400 POLDIP3 ARID2 SYNE2 YLPM1 IKBKG ZFHX3 YY1AP1 TEX10

2.08e-071429631435140242
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

NCOA2 SATB2 KMT2D EP400 ARID2 SYNE2 YY1AP1 CCNB1

6.13e-0739863835016035
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

TRERF1 UBR1 KMT2D ERCC5 SSH1 EP400 ITSN1 YLPM1 YY1AP1 HUWE1

1.24e-06774631015302935
Pubmed

Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.

SYNE1 SYNE2

3.23e-06263222768332
Pubmed

Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.

SYNE1 SYNE2

3.23e-06263211792814
Pubmed

Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.

SYNE1 SYNE2

3.23e-06263224931616
Pubmed

Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.

SYNE1 SYNE2

3.23e-06263217267447
Pubmed

Nesprins: tissue-specific expression of epsilon and other short isoforms.

SYNE1 SYNE2

3.23e-06263224718612
Pubmed

Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.

SYNE1 SYNE2

3.23e-06263224586179
Pubmed

Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.

SYNE1 SYNE2

3.23e-06263217761684
Pubmed

Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.

SYNE1 SYNE2

3.23e-06263231578382
Pubmed

Interaction network of human early embryonic transcription factors.

TRERF1 NCOA2 SATB2 KMT2D EP400 ARID2 ZFHX3

3.42e-0635163738297188
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

EXOSC10 IGF2BP1 KMT2D MYH13 SYNE1 DMD

4.29e-0623463636243803
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

TRERF1 NCOA2 EXOSC10 KMT2D EP400 YLPM1

9.31e-0626863633640491
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

EXOSC10 IGF2BP1 SSH1 POLDIP3 POLD1 CPD TTC13 HUWE1 DMD CCNB1

9.44e-06974631028675297
Pubmed

Lysine methyltransferase 2D regulates muscle fiber size and muscle cell differentiation.

KMT2D DMD

9.68e-06363234613626
Pubmed

Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.

SYNE1 SYNE2

9.68e-06363210878022
Pubmed

The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.

SYNE1 SYNE2

9.68e-06363216079285
Pubmed

The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.

SYNE1 SYNE2

9.68e-06363212408964
Pubmed

Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.

SYNE1 SYNE2

9.68e-06363217462627
Pubmed

Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology.

IKBKG DMD

9.68e-06363221624467
Pubmed

Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.

SYNE1 SYNE2

9.68e-06363233472039
Pubmed

Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.

SYNE1 SYNE2

9.68e-06363225516977
Pubmed

Real-time reverse linkage using polar body analysis for preimplantation genetic diagnosis in female carriers of de novo mutations.

IKBKG DMD

9.68e-06363219687056
Pubmed

cDNAs with long CAG trinucleotide repeats from human brain.

MAGI1 KMT2D EP400

9.78e-06236339225980
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

EXOSC10 EP400 POLDIP3 YLPM1 ZFHX3 TEX10

1.27e-0528363630585729
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

TRERF1 EP400 ARID2 TBC1D5 ITSN1 YLPM1 MAML2

1.28e-0543063735044719
Pubmed

SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.

SYNE1 SYNE2

1.93e-05463216648470
Pubmed

LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.

SYNE1 SYNE2

1.93e-05463223071752
Pubmed

Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.

SYNE1 SYNE2

1.93e-05463220108321
Pubmed

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.

SYNE1 SYNE2

1.93e-05463219596800
Pubmed

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.

SYNE1 SYNE2

1.93e-05463228716842
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

SPTBN5 CCDC73 SYNE1 SYNE2 DMD

2.33e-0518763526460568
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

TRERF1 NCOA2 EXOSC10 SATB2 IGF2BP1 KMT2D EP400 POLDIP3 ARID2 CCNB1

2.75e-051103631034189442
Pubmed

A human MAP kinase interactome.

MAGI1 SYNE1 ARID2 ITSN1 LAMA4 YY1AP1 DMD

2.81e-0548663720936779
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

POLDIP3 POLD1 SYNE1 SYNE2 DMD

2.98e-0519763520811636
Pubmed

Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening.

IKBKG DMD

3.22e-05563233979621
Pubmed

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.

SYNE1 SYNE2

3.22e-05563218396275
Pubmed

LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.

SYNE1 SYNE2

3.22e-05563222632968
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

SATB2 IGF2BP1 SYNE2 YLPM1 HUWE1 CCNB1

4.73e-0535863632460013
Pubmed

Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.

PTPRE PTPRG

4.82e-0566322170109
Pubmed

Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.

SYNE1 SYNE2

4.82e-05663233058875
Pubmed

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

SYNE1 SYNE2

4.82e-05663218827015
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

NCOA2 KMT2D ARID2 YLPM1 ZFHX3

5.05e-0522063535785414
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

NCOA2 EXOSC10 KMT2D EP400 ARID2 YLPM1 HUWE1

6.06e-0554963738280479
Pubmed

Gene expression profiling in embryonic mouse lenses.

IGF2BP1 CCNB1

6.74e-05763217213798
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

SPTBN5 IGF2BP1 POLDIP3 SYNE1 ARID2 SYNE2 CPD TTC13 HUWE1 TMCC1 CCNB1

7.06e-051496631132877691
Pubmed

Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase.

NCOA2 IKBKG

8.98e-05863211971985
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

EXOSC10 IGF2BP1 EP400 POLDIP3 SYNE1 SYNE2 YLPM1 HUWE1 TEX10

9.13e-05102463924711643
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

NCOA2 EP400 POLDIP3 ARID2 ITSN1 YY1AP1 HUWE1

9.29e-0558863738580884
Pubmed

Functional proteomics mapping of a human signaling pathway.

KMT2D ITSN1 YLPM1 IKBKG LAMA4 HUWE1 TEX10

9.59e-0559163715231748
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TRERF1 SATB2 KMT2D IKBKG ZFHX3 HUWE1

1.11e-0441863634709266
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

EXOSC10 IGF2BP1 EP400 POLDIP3 SYNE1 ARID2 YLPM1 DNM3 TEX10

1.38e-04108263938697112
Pubmed

Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family.

EXOSC10 HUWE1 DMD

1.39e-045563331985874
Pubmed

Nuclear membrane proteins with potential disease links found by subtractive proteomics.

SYNE1 SYNE2

1.44e-041063212958361
Pubmed

Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.

SYNE1 SYNE2

1.44e-041063228533284
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

EXOSC10 EP400 ARID2 YLPM1 HUWE1 TEX10

1.46e-0444063634244565
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

NCOA2 RAD51AP2 SATB2 KMT2D ARID2 SYNE2 ITPKB

1.54e-0463863731182584
Pubmed

Comprehensive analysis of DNA repair gene variants and risk of meningioma.

PMS2 ERCC5 POLD1

1.55e-045763318270339
Pubmed

A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.

SYNE1 SYNE2

1.76e-041163222826121
Pubmed

Meta-analysis identifies six new susceptibility loci for atrial fibrillation.

SYNE2 ZFHX3

2.11e-041263222544366
Pubmed

Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration.

ELMO3 DMD

2.11e-041263236400788
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

PMS2 ERCC5 TBC1D5 ITSN1 IKBKG HUWE1

2.37e-0448163628190767
Pubmed

KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.

SYNE1 SYNE2

2.49e-041363221177258
Pubmed

The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.

KMT2D EP400

2.49e-041363216510874
Pubmed

A genome-wide association study for reading and language abilities in two population cohorts.

POLD1 ZFHX3

2.49e-041363223738518
Pubmed

Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk.

ERCC5 POLD1

2.49e-041363218701435
Pubmed

Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.

PMS2 ERCC5 POLD1

2.61e-046863320496165
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

NUGGC MYH13 KIAA0825 POLD1 ARID2 TEX10

2.82e-0449763636774506
Pubmed

SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.

SYNE1 SYNE2

2.90e-041463219874786
Pubmed

CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment.

SATB2 CCNB1

2.90e-041463232518258
Pubmed

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.

NCOA2 KMT2D

2.90e-041463212482968
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

NCOA2 MAGI1 PTPRE PTPRG TBC1D5 ZFHX3 CPD HUWE1 TMCC1 ITPKB

3.24e-041489631028611215
Pubmed

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.

KMT2D EP400

3.34e-041563216510875
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

EXOSC10 POLDIP3 SYNE1 HUWE1 TEX10

3.44e-0433263525693804
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

EXOSC10 EP400 POLD1 ARID2 HUWE1

3.44e-0433263532786267
Pubmed

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

EXOSC10 EP400 POLDIP3 YY1AP1 TEX10

3.78e-0433963530415952
Pubmed

Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina.

PTPRE PTPRG

3.81e-041663218308476
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

PMS2 KMT2D EP400 YLPM1 YY1AP1

3.88e-0434163532971831
Pubmed

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

EXOSC10 SATB2 IGF2BP1 HUWE1 TEX10

4.31e-0434963525665578
Pubmed

Protein tyrosine phosphatases expression during development of mouse superior colliculus.

PTPRE PTPRG

4.32e-041763219727691
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

NCOA2 KMT2D EP400

4.69e-048363328794006
Pubmed

Intermediate Progenitor Cohorts Differentially Generate Cortical Layers and Require Tbr2 for Timely Acquisition of Neuronal Subtype Identity.

SATB2 TBX21

4.85e-041863227320921
Pubmed

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1.

IGF2BP1 SYNE2

4.85e-041863233361760
Pubmed

Cerebral Cortex Expression of Gli3 Is Required for Normal Development of the Lateral Olfactory Tract.

SATB2 TBX21

4.85e-041863226509897
Pubmed

Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.

PMS2 ERCC5 POLD1

4.86e-048463319237606
Pubmed

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.

SYNE2 HUWE1 TEX10

5.03e-048563319596235
Pubmed

Chromatin remodeler Ep400 ensures oligodendrocyte survival and is required for myelination in the vertebrate central nervous system.

EP400 MYRF

5.41e-041963231081019
Pubmed

Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer.

MSANTD3 TEX10

5.41e-041963215334068
Pubmed

Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.

IGF2BP1 EP400 POLD1 HUWE1

5.93e-0421163417314511
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

UBR1 POLD1 ARID2 IKBKG

6.03e-0421263433853758
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

SATB2 EP400 POLD1 ZFHX3 HUWE1 CCNB1

6.54e-0458363629844126
Pubmed

HEY1 functions are regulated by its phosphorylation at Ser-68.

SYNE1 SYNE2 YLPM1

6.96e-049563327129302
Pubmed

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.

SYNE1 ITSN1

7.29e-042263212812986
Pubmed

A novel function for Foxm1 in interkinetic nuclear migration in the developing telencephalon and anxiety-related behavior.

SATB2 CCNB1

7.29e-042263224453338
Pubmed

Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.

SATB2 LAMA4

7.29e-042263235245678
Pubmed

Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.

NCOA2 NUGGC

7.29e-042263223247143
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

TRERF1 EXOSC10 SATB2 EP400 HUWE1

7.63e-0439663526687479
InteractionSP7 interactions

TRERF1 NCOA2 SATB2 IGF2BP1 KMT2D EP400 ARID2 YLPM1 TEX10

3.62e-07304629int:SP7
InteractionFEV interactions

NCOA2 SATB2 KMT2D EP400 ARID2 ZFHX3 YY1AP1

2.92e-06203627int:FEV
InteractionSOX17 interactions

NCOA2 SATB2 KMT2D POLDIP3 ARID2

1.10e-0595625int:SOX17
InteractionCRX interactions

TRERF1 NCOA2 SATB2 KMT2D EP400 ARID2 ZFHX3

1.27e-05254627int:CRX
InteractionEGR2 interactions

TRERF1 NCOA2 KMT2D EP400 ARID2 ZFHX3

1.42e-05171626int:EGR2
InteractionHNF1B interactions

NCOA2 SATB2 KMT2D EP400 ARID2 ZFHX3

2.57e-05190626int:HNF1B
InteractionTLX3 interactions

NCOA2 SATB2 KMT2D POLDIP3 ARID2 TBX21 ZFHX3

3.04e-05291627int:TLX3
InteractionPAX9 interactions

NCOA2 SATB2 KMT2D TBX21 ZFHX3

4.98e-05130625int:PAX9
InteractionSYNC interactions

BICDL2 ITSN1 IKBKG MAML2

5.38e-0567624int:SYNC
InteractionSOX15 interactions

NCOA2 SATB2 IGF2BP1 KMT2D ARID2

7.33e-05141625int:SOX15
InteractionTLX2 interactions

SATB2 IGF2BP1 KMT2D POLDIP3 ZFHX3

7.58e-05142625int:TLX2
InteractionPCNT interactions

ODAD1 POLD1 SYNE1 DNM3 YY1AP1 HUWE1

9.65e-05241626int:PCNT
InteractionKPNA1 interactions

EXOSC10 EP400 ARID2 YLPM1 IKBKG HUWE1 TEX10

9.89e-05351627int:KPNA1
InteractionNUP43 interactions

KMT2D ERCC5 EP400 POLD1 ARID2 SYNE2 IKBKG ZFHX3 TEX10

1.17e-04625629int:NUP43
InteractionSOX7 interactions

NCOA2 SATB2 KMT2D ARID2

1.19e-0482624int:SOX7
InteractionSOX6 interactions

NCOA2 SATB2 IGF2BP1 POLDIP3 ZFHX3

1.22e-04157625int:SOX6
InteractionSOX5 interactions

SATB2 IGF2BP1 KMT2D POLDIP3 ZFHX3

1.41e-04162625int:SOX5
InteractionGSC interactions

SATB2 KMT2D TBX21 ZFHX3

1.49e-0487624int:GSC
InteractionHOXB2 interactions

SATB2 KMT2D SYNE2

1.84e-0436623int:HOXB2
InteractionHNF4A interactions

NCOA2 SATB2 KMT2D EP400 ARID2 DMD

1.98e-04275626int:HNF4A
InteractionTLX1 interactions

NCOA2 SATB2 IGF2BP1 KMT2D ZFHX3

2.02e-04175625int:TLX1
InteractionLHX2 interactions

SATB2 KMT2D EP400 ARID2 ZFHX3

2.49e-04183625int:LHX2
InteractionLHX3 interactions

SATB2 KMT2D ARID2 SYNE2 DMD

2.62e-04185625int:LHX3
InteractionLHX1 interactions

SATB2 KMT2D ARID2 TEX10

2.86e-04103624int:LHX1
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

TRERF1 MSANTD1 MSANTD3 EP400

9.80e-0653464532
GeneFamilyAtaxins|Trinucleotide repeat containing

MAGI1 KMT2D EP400

3.41e-0525463775
GeneFamilySpectrin repeat containing nuclear envelope family

SYNE1 SYNE2

3.79e-0544621252
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRE PTPRG

1.29e-0321462813
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

NCOA2 MAGI1 SATB2 SYNE1 TBC1D5 DNM3 MAML2

9.37e-09189637830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

NCOA2 MAGI1 PTPRG TBC1D5 MAML2 DMD TMCC1

1.20e-08196637ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

NCOA2 MAGI1 PTPRG TBC1D5 MAML2 DMD TMCC1

1.29e-081986371996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI1 SATB2 SYNE1 SYNE2 DNM3 MAML2

3.29e-07194636e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIAA0825 ODAD1 SYNE1 SYNE2 FAM227A DMD

3.60e-0719763674a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SATB2 PTPRE SYNE1 SYNE2 TMCC1

4.92e-06175635cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SATB2 SYNE1 DNM3 MAML2 ENOX2

5.20e-06177635da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Alveolar_Epithelial_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BICDL2 MAGI1 ELMO3 CCDC149 MYRF

5.50e-0617963588dbec952507d84b85b08165eec80df99ed1e736
ToppCellfacs-Lung-EPCAM-3m-Epithelial-type_I_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BICDL2 MAGI1 ELMO3 CCDC149 MYRF

5.50e-06179635daf8189a22786171e2b629261cf720736aa4ebdb
ToppCellRA-01._Fibroblast_I|World / Chamber and Cluster_Paper

MYH13 PTPRG ZFHX3 MAML2 PDZRN4

5.80e-061816352b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPRE SYNE1 SYNE2 TBX21 CPD

5.80e-0618163512ff56fa2949c8d53360cdf2cacfd326e65b54aa
ToppCellCOVID-19-Heart-EC_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

MAGI1 PTPRG SYNE1 SYNE2 ITPKB

7.16e-06189635fe49852ba15f948b384d6b4c258927c70b741357
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI1 SATB2 SYNE2 DNM3 MAML2

7.53e-06191635d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI1 PTPRG TBC1D5 SYNE2 MAML2

7.72e-06192635e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPRE SYNE1 SYNE2 TBX21 CPD

8.54e-06196635c100967851f037b3522130a9e2a4175ad593ecbc
ToppCellControl-Control-Lymphocyte-T/NK-NK_activated|Control / Disease, condition lineage and cell class

NUGGC SYNE1 SYNE2 PARP9 ITPKB

8.97e-0619863576d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCellSepsis-Leuk-UTI-Lymphocyte-T/NK-gd_T|Leuk-UTI / Disease, condition lineage and cell class

NUGGC SYNE1 SYNE2 TBX21 IPP

9.19e-06199635b2c1b9ee764e1246bfa3ecf666ca76ae4ac6c362
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

NCOA2 MAGI1 TBC1D5 MAML2 DMD

9.19e-0619963594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

SYNE1 SYNE2 TBX21 PARP9 HUWE1

9.41e-062006352281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellVE-CD4-CD4_Treg|VE / Condition, Cell_class and T cell subcluster

IGF2BP1 ODAD1 SYNE2 DNM3

3.37e-05129634e89d414e1b23e1656747defa39f09b51944a2166
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAD51AP2 TBC1D5 TBX21 TTC13

6.07e-0515063453de595376a9fc92491dfd58ff25938b0bf79903
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAD51AP2 TBC1D5 TBX21 TTC13

6.07e-05150634e4b40b3243ed26d0c46bf196ac06e148834e7ed2
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SSH1 ADAMTS17 CPD TTC13

6.72e-05154634d2aa24c593a1c0c6f186b74a18438b64b4e59701
ToppCellNS-moderate-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TEKT2 CCDC73 KIAA0825 FAM227A

7.24e-05157634410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCellInfluenza_Severe-gd_T|World / Disease group and Cell class

NUGGC SYNE1 SYNE2 TBX21

7.98e-05161634b3cdaed4d58d57e3c5dbc904a09388f3bf949407
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMK+-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

BICDL2 SYNE1 SYNE2 TBX21

8.18e-0516263419395bdb282b4a2d88cd33191af12c24a88c3d16
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ELMO3 SYNE1 SYNE2 TBX21

8.57e-05164634c4ad98106e8663caf7c1c15d30ec633d8bd8cf57
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ELMO3 SYNE1 SYNE2 TBX21

8.57e-05164634ed7277f8980f96f5b3e4eed025d46d0942e123d7
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TEKT2 IPP FAM227A PARP9

9.20e-05167634774f3264318b002d0df5d06d41d645366038d0bf
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAD51AP2 TEKT2 ODAD1 ENOX2

9.41e-051686349a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8|TCGA-Thryoid / Sample_Type by Project: Shred V9

PTPRG SSH1 DMD PDZRN4

9.41e-0516863400646601548b0fee42ae16bfa5e93603bc7c5129
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYH13 PTPRG LAMA4 MAML2

9.63e-05169634c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellsevere_influenza-gd_T|World / disease group, cell group and cell class (v2)

NUGGC SYNE1 SYNE2 TBX21

9.63e-051696346d514dd2d1e5253bce49279f43aa2fa2b7c2653e
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

MYH13 PTPRG ZFHX3 MAML2

9.63e-051696346373562ab3b1765060212a6a53d6543e7e942e80
ToppCellnormal-na-Lymphocytic_NK-natural_killer_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

SPTBN5 SYNE1 SYNE2 MYRF

1.01e-04171634d339840626211a7bf1a9eb8f14d6c9509ab05e1c
ToppCellmild-Myeloid-Eosinophils|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TRERF1 REXO5 SYNE1 SYNE2

1.01e-041716345c8198182495bda7a826e9d80aa467f4eb1094ec
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LAMA4 ZFHX3 DMD PDZRN4

1.05e-04173634cb6389536195443633adb06e5f1b7483530773d1
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYH13 PTPRG DNM3 MAML2

1.08e-04174634f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRERF1 SYNE1 SYNE2 TBX21

1.13e-041766345914e7635474e7cf24d446bdb1423bc0807ee9c6
ToppCell10x5'-lymph-node_spleen-Lymphocytic_B-GC_B_(II)|lymph-node_spleen / Manually curated celltypes from each tissue

NUGGC SYNE2 DMD PDZRN4

1.13e-041766345788dd5b23ebb52f19d3b5bdbcfe25dee349cf77
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SATB2 SYNE1 DNM3 MAML2

1.13e-04176634327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MSANTD3 SYNE1 SYNE2 CCNB1

1.18e-0417863415a99080e9f669572ab6d82934f324e6714846c1
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MSANTD3 SYNE1 SYNE2 CCNB1

1.18e-04178634200308e109abb7e6f8816a6f8cce6d56862d4098
ToppCellLA-01._Fibroblast_I|LA / Chamber and Cluster_Paper

MYH13 PTPRG ZFHX3 MAML2

1.20e-04179634dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCellControl-Fibroblasts-Airway_smooth_muscle|Control / group, cell type (main and fine annotations)

LAMA4 ZFHX3 DMD PDZRN4

1.23e-04180634d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCelldroplet-Heart-nan-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 SYNE2 DNM3 ITPKB

1.25e-0418163492d44892bb15771f0ab5fe61879b204b0acbd9b3
ToppCelldroplet-Heart-nan-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 SYNE2 DNM3 ITPKB

1.28e-0418263481279877b920b5a1bc991a07d3031d6458700fe3
ToppCellCOVID-19_Mild-gd_T|COVID-19_Mild / Disease condition and Cell class

NUGGC SYNE1 SYNE2 TBX21

1.31e-04183634f593a89b0aa8fffdfa403769916facfd30358521
ToppCellsevere-multiplets|severe / disease stage, cell group and cell class

SPTBN5 ELMO3 ODAD1 SYNE1

1.31e-0418363478af8df48f0fe49ac37ccec0ad7b2993883b1148
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Lymphocytic-T_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELMO3 POLD1 MFSD13A CCNB1

1.34e-04184634185b49630da61cbf45c0926d1b992943296d2a54
ToppCellBAL-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TRERF1 NUGGC SYNE2 TBX21

1.36e-04185634191d7e9b34bd1598cb4c18e0cb3d018bad83c757
ToppCellBAL-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TRERF1 NUGGC SYNE2 TBX21

1.36e-0418563499fe59c15c3c0f7afa7e182255e4bacfba346132
ToppCellfacs-BAT-Fat-24m-Epithelial-Epcam+|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BICDL2 SATB2 ELMO3 PDZRN4

1.39e-04186634b18d7398279a2d42414318aeb70514fd402f5a0a
ToppCellMild-Lymphoid-T-NK|Mild / Condition, Lineage, Cell class and cell subclass

TRERF1 NUGGC SYNE1 TBX21

1.39e-04186634ed37a2df547661d22c1ed0b30cb1c19e489d9d0a
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SYNE1 ZFHX3 DMD PDZRN4

1.39e-041866344780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SATB2 PTPRG SYNE1 SYNE2

1.39e-04186634f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Lymphocytic|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELMO3 POLD1 MFSD13A CCNB1

1.42e-04187634e53471c3e146a6f54788d81ecc469aba55b051bb
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Lymphocytic-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELMO3 POLD1 MFSD13A CCNB1

1.42e-041876343d7d51fbadb20dc884d0b3c0d61b80f022b19d09
ToppCellCOVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

MAGI1 PTPRG DNM3 PDZRN4

1.42e-041876342d20193a6cacdfa4877457c97b0077408942186c
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SATB2 PTPRG SYNE2 CPD

1.42e-04187634c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SSH1 SYNE1 SYNE2 TBX21

1.42e-04187634cfdc1585c80d2bb475d9145395fb50a88c53f838
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SSH1 SYNE1 SYNE2 TBX21

1.42e-04187634b426a67b5669019115b58295ce7d304beeb75825
ToppCelldroplet-Marrow-nan-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MSANTD3 SYNE1 SYNE2 MFSD13A

1.42e-0418763414c239af77116d28d511dea754b6150d20488080
ToppCellCOPD-Lymphoid-NK|COPD / Disease state, Lineage and Cell class

TRERF1 SYNE1 SYNE2 TBX21

1.45e-04188634c9a227c8e71b69929d43e9afb8306a95c8163778
ToppCell368C-Epithelial_cells-Epithelial-I_(AT1)-|368C / Donor, Lineage, Cell class and subclass (all cells)

BICDL2 MSANTD3 TTC13 MFSD13A

1.45e-04188634c74771584b3ba9561a99a54bf55a9203ddf8eff8
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SATB2 PTPRG SYNE2 CPD

1.45e-04188634af740fa78542438fdff627ea1f74f4eee43316be
ToppCell368C-Epithelial_cells-Epithelial-I_(AT1)|368C / Donor, Lineage, Cell class and subclass (all cells)

BICDL2 MSANTD3 TTC13 MFSD13A

1.45e-041886349155b9a92496e75646778c025b02947e9e9ec73a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SATB2 SYNE1 DNM3 MAML2

1.45e-0418863463a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTPRE LAMA4 MAML2 DMD

1.45e-04188634997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCellCOPD-Lymphoid-NK|World / Disease state, Lineage and Cell class

TRERF1 SYNE1 SYNE2 TBX21

1.48e-04189634c0ac160fa7e68b92414fb1600abcac8ad1a42232
ToppCellIPF-Lymphoid-NK|IPF / Disease state, Lineage and Cell class

TRERF1 SYNE1 SYNE2 TBX21

1.48e-04189634d92e880162450f8d01e4b8784eb625275cb8e03e
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZFHX3 MAML2 MYRF ITPKB

1.48e-0418963442ab4cc5fbf8580841f31889446fe4499df1a464
ToppCellCOPD-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

TEKT2 KIAA0825 ODAD1 FAM227A

1.48e-041896343e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCellCOVID-19-T_cells-NK_cells|COVID-19 / group, cell type (main and fine annotations)

TRERF1 SYNE1 SYNE2 TBX21

1.48e-04189634b699152dfbb8cd8ed724e1e5a51838f29b681b62
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SATB2 SYNE1 SYNE2 MAML2

1.51e-04190634b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SATB2 SYNE1 DNM3 CPD

1.51e-041906343fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell(4)_Endothelial_cells-(40)_EC-arterial|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis

SYNE1 DNM3 LAMA4 ITPKB

1.51e-04190634ff774faf3f12759d11e50ed7d189288bb79e22e1
ToppCell3'_v3-blood-Lymphocytic_T_CD8-Tem/emra_CD8|blood / Manually curated celltypes from each tissue

NUGGC SYNE1 SYNE2 TBX21

1.51e-041906345624f711b34132081f93fa70702316962e3e3c64
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MSANTD3 PTPRE SYNE1 TBX21

1.54e-0419163404faa7d2237e45418611153294eb6f7bb690cbde
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PTPRG SSH1 ADAMTS17 LAMA4

1.54e-0419163408720998aa55131d7377c4c67c4c935865bd7d79
ToppCellIPF-Lymphoid-NK|World / Disease state, Lineage and Cell class

TRERF1 SYNE1 SYNE2 TBX21

1.54e-04191634f206159b9d5e84cf14a65bfdc008895cec5a8081
ToppCellControl-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

MAGI1 PTPRG SYNE1 SYNE2

1.57e-041926341bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PTPRG SYNE2 DNM3 ITPKB

1.57e-0419263427ff3621e177e7932dd44dd6baa81551ea75a874
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 LAMA4 DMD PDZRN4

1.57e-041926345105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 LAMA4 DMD PDZRN4

1.57e-04192634d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SSH1 SYNE1 SYNE2 TBX21

1.57e-0419263497c312c82ec025c13052f8d424b11c0034c8ea54
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SSH1 SYNE1 SYNE2 TBX21

1.57e-041926343b0a52e4e77ae4539a034dcb419773b8e2aa5d51
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

MAGI1 PTPRG LAMA4 PDZRN4

1.60e-04193634cf2461af78f65616ce40d552ee9452295e3895ed
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SATB2 SYNE1 SYNE2 MAML2

1.60e-041936340f2167eef8203a5659c8c72e4e77646003d64797
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

KIAA0825 SYNE1 FAM227A DMD

1.60e-04193634ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

MAGI1 PTPRG LAMA4 PDZRN4

1.60e-041936346ef9007c9d18fb775d08fb20cdf954a28d54d7eb
ToppCellInfluenza_Severe-CD8+_Tem|World / Disease group and Cell class

NUGGC SYNE1 SYNE2 TBX21

1.60e-04193634fce6138712353fba14eb046e10d54e112372658e
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

MAGI1 PTPRG LAMA4 PDZRN4

1.60e-04193634e4ea7ce011a80b81b841c907719aa532bed39d2e
ToppCellILEUM-inflamed-(3)_moDC|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CLEC4F PTPRE ITSN1 ZFHX3

1.64e-04194634c9d2acab0bbcfa9a9113cf3b9f8147403f0beb43
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAGI1 PTPRG KIAA0825 ITPKB

1.64e-041946340b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellT_cells-CD56_dim_CD16+_NK_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

SYNE1 SYNE2 TBX21 MYRF

1.64e-04194634335c6c2f3f319d4f19eace62f8826a0f40c130f6
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

MAGI1 SYNE1 SYNE2 FAM227A

1.67e-04195634fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellCOVID-19_Severe-CD8+_Tem|COVID-19_Severe / Disease condition and Cell class

NUGGC SYNE1 SYNE2 TBX21

1.67e-04195634ff7ae62393e1c858a10592db8e6d9f36b8bae396
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 ITSN1 LAMA4 DMD

1.67e-04195634cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRE PTPRG SSH1 DNM3

1.67e-04195634818bc18c5834238e5f733cac6fe928ed0788f57d
DiseaseAutosomal dominant Emery-Dreifuss muscular dystrophy

SYNE1 SYNE2

2.43e-054602cv:CN293514
Diseasesuicidal ideation

NCOA2 NUGGC ZFHX3

2.81e-0529603EFO_0004320
Diseasesevere acute respiratory syndrome, COVID-19

NCOA2 MAGI1 PMS2 ADAMTS17 ZFHX3 MAML2 DMD

3.38e-05447607EFO_0000694, MONDO_0100096
DiseaseAutosomal Recessive Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

4.05e-055602C1450051
DiseaseAutosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)

SYNE1 SYNE2

4.05e-055602C0410190
DiseaseEmery-Dreifuss muscular dystrophy

SYNE1 SYNE2

6.07e-056602cv:C0410189
DiseaseMuscular Dystrophy, Emery-Dreifuss

SYNE1 SYNE2

6.07e-056602C0410189
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

8.48e-057602C0751337
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

IGF2BP1 PTPRG YLPM1 ZFHX3 TEX10 PDZRN4

9.66e-05364606EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Diseaseunipolar depression

NCOA2 MYH13 PTPRG CCDC73 TBC1D5 SYNE2 YLPM1 ZFHX3 DMD ITPKB

1.47e-0412066010EFO_0003761
Diseaselung non-small cell carcinoma (is_implicated_in)

NCOA2 KMT2D ERCC5 ZFHX3

1.87e-04139604DOID:3908 (is_implicated_in)
Diseasepolybrominated biphenyl measurement, gestational serum measurement, fetal genotype effect measurement, polybrominated diphenyl ether measurement

TBC1D5 ZFHX3

2.21e-0411602EFO_0007959, EFO_0007961, EFO_0007962, EFO_0007964
DiseaseMicrophthalmos

KMT2D MYRF

2.21e-0411602C0026010
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

SYNE1 SYNE2

2.65e-0412602DOID:11726 (implicated_via_orthology)
Diseasebody fat percentage

IGF2BP1 PTPRG YLPM1 ZFHX3 TEX10 PDZRN4

4.67e-04488606EFO_0007800
Diseaseovarian carcinoma

PTPRG DNM3 LAMA4 ZFHX3 DMD

4.94e-04321605EFO_0001075
DiseaseColorectal Carcinoma

SATB2 PMS2 POLD1 SYNE1 IPP DMD PDZRN4

5.42e-04702607C0009402
Diseasesphingomyelin 14:0 measurement

SYNE2 ZFHX3

5.42e-0417602EFO_0010390
Diseasebreast cancer (is_marker_for)

PMS2 KMT2D ZFHX3 CCNB1

5.55e-04185604DOID:1612 (is_marker_for)
DiseaseQT interval

NCOA2 PTPRG ARID2 ITSN1 ZFHX3 MYRF

7.48e-04534606EFO_0004682
Diseasetestosterone measurement

MAGI1 UBR1 SATB2 PTPRG CCDC73 SYNE2 DNM3 ZFHX3 YY1AP1

1.04e-031275609EFO_0004908
Diseasealpha-linolenic acid measurement

KIAA0825 MYRF

1.18e-0325602EFO_0007759
Diseasebrain connectivity measurement

MAGI1 SATB2 SSH1 TBC1D5 MFSD13A

1.32e-03400605EFO_0005210
Diseasestimulant use measurement

NCOA2 PDZRN4

1.49e-0328602EFO_0600076
Diseasecortical thickness

NCOA2 MAGI1 SATB2 IGF2BP1 KIAA0825 TBC1D5 YLPM1 PDZRN4

1.80e-031113608EFO_0004840

Protein segments in the cluster

PeptideGeneStartEntry
IHMKVQPLNQTALQV

PTPRG

351

P23470
IGSMHQVNQKIADIN

FAM227A

51

F5H4B4
VHMQQLLKLKQQAVQ

EP400

2961

Q96L91
MLSVKRQQQQQHSPA

ARID2

1006

Q68CP9
QMNKLRKIQNHIQTL

DMD

1046

P11532
NMFQHQSLGIKINIQ

ADAMTS17

266

Q8TE56
GIQNLITRNMNTNIK

RAD51AP2

546

Q09MP3
QNIMQAHRLQKVTDQ

PDZRN4

681

Q6ZMN7
QLILAQINKMRNGQH

IPP

21

Q9Y573
AMVVNNLTLQIVQGH

PARP9

311

Q8IXQ6
QHILQVQSLQLQERM

MSANTD1

251

Q6ZTZ1
GMIDLIAAVQKQQQQ

PTPRE

606

P23469
VIGKSHQLVVQLMQQ

MAGI1

896

Q96QZ7
HQLVVQLMQQAAKQG

MAGI1

901

Q96QZ7
QLMQQAAKQGHVNLT

MAGI1

906

Q96QZ7
HNQMIQKVIQSIEQQ

KIAA0825

1066

Q8IV33
QTRQAIMKLNGHQLE

IGF2BP1

131

Q9NZI8
LLQQALQGMQQHLLK

ENOX2

456

Q16206
RMGTPHLQKVLNQQL

DNM3

271

Q9UQ16
LQQQHSVQVDQLRMQ

IKBKG

191

Q9Y6K9
QLIQMNEVHVAKIQQ

MSANTD3

211

Q96H12
TAKTQHNGMNNIIRL

HUWE1

2201

Q7Z6Z7
HLLQEQQQKVLQQRM

ODAD1

336

Q96M63
CNQTVKTVLQGQMQR

OR6V1

291

Q8N148
LKQIAANRQQHARMQ

MAML2

436

Q8IZL2
LVRQQINEMHLLIQQ

EXOSC10

561

Q01780
QHLAKNVVMVNQGLT

CCNB1

381

P14635
NMVIQHQRQTNKILG

CCDC149

256

Q6ZUS6
LEKMHQAAQNTIRQQ

BBIP1

66

A8MTZ0
HLQQQLQESQQMLGR

ITSN1

526

Q15811
IISFQHMQQLLRQQI

CCDC73

281

Q6ZRK6
NRRSLIQFMKQVHQG

CPD

781

O75976
LLVHLQVMNQQLQTK

ELMO3

216

Q96BJ8
MQVVIGQQLRSQRQK

BICDL2

456

A1A5D9
LMTQAERQKQAHQRQ

FAM27E3

36

Q08E93
QQVKVVSQLLRQAMH

POLD1

551

P28340
LHMVKAQRQNLSQAQ

MFSD13A

496

Q14CX5
GMRINVVNNHQAKQN

POLDIP3

166

Q9BY77
LNVHMKNGQVIVKVN

LAMA4

1696

Q16363
AQERMQHQFQQLKTG

NUGGC

706

Q68CJ6
VVNQRCHQMKERLQQ

SYNE1

6471

Q8NF91
IAIAQENKIQLQQMG

SYNE1

7826

Q8NF91
IQQQILQQKHSMILL

SYNE2

1786

Q8WXH0
RELQNVQVNQKVGMF

ITPKB

136

P27987
QKEMNQQHSGHIRRQ

ERCC5

251

P28715
LVRQQIAMAHLINQQ

SATB2

306

Q9UPW6
QEVQQQLNSDHRGKM

TEKT2

166

Q9UIF3
HLQGQRKQVADMQAV

SPTBN5

521

Q9NRC6
LMQHQESIIQLQKAG

SSH1

806

Q8WYL5
TLNAQIQVLNGHMKN

CLEC4F

371

Q8N1N0
EILNQHLRQRQMHQQ

NCOA2

1241

Q15596
LNQNHVQTLQLRGMM

TTC13

346

Q8NBP0
QNHLNNVVVFVLQGM

REXO5

91

Q96IC2
ALQNRQHNGLKALMQ

UBR1

1346

Q8IWV7
IQLGHSNRQMAETQK

MYH13

1631

Q9UKX3
HMLTNAILVQQIIKN

TEX10

876

Q9NXF1
KMTHNALENINVIGQ

TMCC1

36

O94876
LQQLQQMHQKQMQCV

YLPM1

61

P49750
QYQGIMQKHTQLQQI

YLPM1

401

P49750
MLQQHTVLQGQRLIA

PMS2

711

P54278
KRLQQQMQQHVQLLT

YY1AP1

166

Q9H869
HHLQQQQQQQRLMKS

TBC1D5

506

Q92609
NQHQTEMIITKQGRR

TBX21

151

Q9UL17
QQNMTQIQHNRHLGL

ZFHX3

836

Q15911
RIQVNNMAQVLHTQS

TRERF1

156

Q96PN7
GLMGHRLVTAQQQQQ

KMT2D

3846

O14686
TQQSQMLHQLLQQHG

MYRF

231

Q9Y2G1