Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF131 ZNF17 ZNF28 ZBTB39 ZBTB17 ZNF607 ZNF780A GLI3 ZNF189 ZNF300 ZNF814 ZNF860 ZNF227 ZNF442 ZBTB24

4.44e-0514126615GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF131 ZNF17 ZNF28 ZBTB39 ZBTB17 ZNF607 ZNF780A GLI3 ZNF189 ZNF300 ZNF814 ZNF860 ZNF227 ZBTB24

4.50e-0512446614GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF131 ZNF17 ZNF28 ZBTB39 ZBTB17 ZNF607 ZNF780A GLI3 ZNF189 ZNF300 ZNF814 ZNF860 ZNF227 ZBTB24

5.68e-0512716614GO:0000987
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF131 ZNF17 ZNF28 ZBTB39 ZBTB17 ZNF607 ZNF780A GLI3 ZNF189 ZNF300 ZNF814 ZNF860 ZNF227 ZNF442 ZBTB24

6.47e-0514596615GO:0000977
DomainZnf_C2H2-like

ZNF131 ZNF17 ZNF28 ZBTB39 ZBTB17 AKAP8 ZNF607 ZNF780A GLI3 ZNF189 ZNF638 ZNF300 ZNF814 ZNF860 ZNF227 ZNF230 ZNF839 ZNF442 ZNF365 ZBTB24

1.97e-127966620IPR015880
DomainZnf_C2H2

ZNF131 ZNF17 ZNF28 ZBTB39 ZBTB17 AKAP8 ZNF607 ZNF780A GLI3 ZNF189 ZNF638 ZNF300 ZNF814 ZNF860 ZNF227 ZNF230 ZNF839 ZNF442 ZNF365 ZBTB24

2.42e-128056620IPR007087
DomainZnF_C2H2

ZNF131 ZNF17 ZNF28 ZBTB39 ZBTB17 AKAP8 ZNF607 ZNF780A GLI3 ZNF189 ZNF638 ZNF300 ZNF814 ZNF860 ZNF227 ZNF230 ZNF839 ZNF442 ZNF365 ZBTB24

2.59e-128086620SM00355
DomainZINC_FINGER_C2H2_2

ZNF131 ZNF17 ZNF28 ZBTB39 ZBTB17 ZNF607 ZNF780A GLI3 ZNF189 ZNF300 ZNF814 ZNF860 ZNF227 ZNF230 ZNF839 ZNF442 ZBTB24

1.01e-097756617PS50157
DomainZINC_FINGER_C2H2_1

ZNF131 ZNF17 ZNF28 ZBTB39 ZBTB17 ZNF607 ZNF780A GLI3 ZNF189 ZNF300 ZNF814 ZNF860 ZNF227 ZNF230 ZNF839 ZNF442 ZBTB24

1.05e-097776617PS00028
Domain-

ZNF131 ZNF17 ZNF28 ZBTB39 ZBTB17 ZNF607 ZNF780A GLI3 ZNF189 ZNF300 ZNF814 ZNF860 ZNF227 ZNF230 ZNF442 ZBTB24

1.23e-0967966163.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZNF131 ZNF17 ZNF28 ZBTB39 ZBTB17 ZNF607 ZNF780A GLI3 ZNF189 ZNF300 ZNF814 ZNF860 ZNF227 ZNF230 ZNF442 ZBTB24

1.68e-096946616IPR013087
Domainzf-C2H2

ZNF131 ZNF17 ZNF28 ZBTB39 ZBTB17 ZNF607 ZNF780A ZNF189 ZNF300 ZNF814 ZNF860 ZNF227 ZNF230 ZNF442 ZBTB24

1.38e-086936615PF00096
DomainKRAB

ZNF17 ZNF28 ZNF607 ZNF780A ZNF189 ZNF300 ZNF814 ZNF860 ZNF227 ZNF230 ZNF442

4.61e-083586611PS50805
DomainKRAB

ZNF17 ZNF28 ZNF607 ZNF780A ZNF189 ZNF300 ZNF814 ZNF860 ZNF227 ZNF230 ZNF442

4.61e-083586611PF01352
DomainKRAB

ZNF17 ZNF28 ZNF607 ZNF780A ZNF189 ZNF300 ZNF814 ZNF860 ZNF227 ZNF230 ZNF442

6.27e-083696611SM00349
DomainKRAB

ZNF17 ZNF28 ZNF607 ZNF780A ZNF189 ZNF300 ZNF814 ZNF860 ZNF227 ZNF230 ZNF442

6.44e-083706611IPR001909
Domainzf-C2H2_6

ZNF17 ZNF607 ZNF780A ZNF814 ZNF860 ZNF227 ZNF442 ZBTB24

1.44e-05314668PF13912
DomainPectin_lyas_fold

SHCBP1 CEMIP

1.83e-046662IPR012334
Domain-

SHCBP1 CEMIP

1.83e-0466622.160.20.10
Domain-

TXNRD3 AIFM3

2.55e-0476623.30.390.30
DomainPyr_nucl-diS_OxRdtase_dimer

TXNRD3 AIFM3

3.40e-048662IPR004099
DomainFAD/NAD-linked_Rdtase_dimer

TXNRD3 AIFM3

3.40e-048662IPR016156
DomainPectin_lyase_fold/virulence

SHCBP1 CEMIP

3.40e-048662IPR011050
DomainBTB

ZNF131 ZBTB39 ZBTB17 ZBTB24

1.19e-03131664PF00651
DomainPyr_redox_2

TXNRD3 AIFM3

2.02e-0319662PF07992
DomainBTB

ZNF131 ZBTB39 ZBTB17 ZBTB24

2.47e-03160664PS50097
DomainBTB

ZNF131 ZBTB39 ZBTB17 ZBTB24

3.78e-03180664SM00225
DomainBTB/POZ_dom

ZNF131 ZBTB39 ZBTB17 ZBTB24

4.16e-03185664IPR000210
DomainSKP1/BTB/POZ

ZNF131 ZBTB39 ZBTB17 ZBTB24

4.49e-03189664IPR011333
Pubmed

Nup358 and Transportin 1 Cooperate in Adenoviral Genome Import.

TNPO1 RANBP2

3.55e-06266232161167
Pubmed

De novo mutations in epileptic encephalopathies.

RALGAPB ALG13

3.55e-06266223934111
Pubmed

UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.

RANBP2 NAA15 LPP

8.47e-062166337422473
Pubmed

Treatment response to low-dose ketamine infusion for treatment-resistant depression: A gene-based genome-wide association study.

NTRK2 GRIN2A

2.12e-05466233370585
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF131 ZBTB17 PDLIM1 HSPBAP1 GLI3 LPP ZNF638 ZNF300 ZBTB24

2.14e-0580866920412781
Pubmed

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.

TNPO1 PDLIM1 RBM12B RBMS1 LPP ZNF638

3.03e-0531566626777405
Pubmed

Karyopherin beta2 mediates nuclear import of a mRNA binding protein.

TNPO1 RANBP2

5.29e-0566629144189
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

ZNF131 RANBP2 NAA15 PDLIM1 HSPH1 LPP ZNF638 ANKHD1 HERC4

6.57e-0593466933916271
Pubmed

Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.

RANBP2 PLAA AKAP8 AVL9 LPP

8.62e-0523566528378594
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

TNPO1 RANBP2 NAA15 AKAP8 SHCBP1 LPP PTPN21 ANKHD1 SBSN

9.04e-0597466928675297
Pubmed

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.

TNPO1 LRRK2

1.27e-04966221983832
Pubmed

Genome-wide association study of smoking initiation and current smoking.

NTRK2 GRIN2A

1.27e-04966219268276
Pubmed

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.

TNPO1 RANBP2 NAA15 PDLIM1 HSPH1 ERMP1

1.51e-0442266627342126
Pubmed

RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.

TNPO1 AKAP8 HSPH1 ALG13

1.85e-0414866435676246
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

TNPO1 PLAA ZNF780A HSPH1 LPP ZNF638 ANKHD1 HERC4 ZBTB24

2.02e-04108466911544199
Pubmed

The DNA sequence and biology of human chromosome 19.

ZNF17 AKAP8 ZNF780A ZNF814 ZNF230

2.09e-0428466515057824
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

RANBP2 AKAP8 HSPBAP1 HSPH1

2.10e-0415366426365490
Pubmed

P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity.

HSPH1 LRRK2

2.31e-041266229519959
Pubmed

ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.

ZBTB39 ZBTB17 ZBTB24

2.39e-046366334351428
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

KCNT2 ZNF607 AVL9 RBMS1 LRRK2 PTPN21 ANKHD1

3.20e-0468666729987050
Pubmed

Identification of potential protein interactors of Lrrk2.

AKAP8 LRRK2

3.67e-041566217400507
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF17 ZNF607 ZNF780A ZNF227

3.98e-0418166437372979
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

TNPO1 RANBP2 AKAP8 RBMS1 HSPH1 ANKHD1 CPED1

4.42e-0472466736232890
Pubmed

Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

ZNF131 ZBTB17

4.74e-04176627557990
Pubmed

The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.

TNPO1 RANBP2

4.74e-041766210668806
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

RBM12B RBMS1 PIWIL1 ZNF638 ANKHD1

5.21e-0434766516033648
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

TNPO1 RANBP2 AKAP8 RBM12B HSPH1 ZNF638 ISG20L2 SBSN

5.55e-0498966836424410
Pubmed

Daxx Inhibits HIV-1 Reverse Transcription and Uncoating in a SUMO-Dependent Manner.

TNPO1 RANBP2

5.94e-041966232545337
Pubmed

Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

ZNF227 ZNF230

6.59e-042066212743021
Pubmed

Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.

GLI3 SHCBP1 CPED1

7.50e-04936637829101
Pubmed

Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities.

TNPO1 ZBTB24

7.99e-042266231839203
Pubmed

Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.

GRIN2A CSMD3

7.99e-042266235245678
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

TNPO1 AKAP8 RBM12B RBMS1 ZNF638 ANKHD1 ALG13

8.38e-0480766722681889
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

RANBP2 ZBTB39 ZBTB17 HSPH1 ZNF189 ZBTB24

8.38e-0458366629844126
Pubmed

The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression.

PDLIM1 RBMS1 ANKHD1

8.47e-049766337151849
Pubmed

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

LRRK2 ZNF365

1.30e-032866218587394
Pubmed

Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.

TNPO1 NAA15

1.30e-032866235227662
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

TNPO1 RANBP2 NAA15 LRRIQ1 AKAP8 PDLIM1 HSPH1 ANKHD1

1.46e-03114966835446349
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

NAA15 SHCBP1 RALGAPB ZNF638 ANKHD1 CEMIP

1.46e-0365066638777146
Pubmed

Suppressor of fused controls cerebellar neuronal differentiation in a manner modulated by GLI3 repressor and Fgf15.

PDLIM1 GLI3

1.49e-033066228560839
Pubmed

DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC.

RANBP2 HSPH1 ZBTB24

1.49e-0311866337105989
Pubmed

C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.

TNPO1 NAA15 HSPH1

1.53e-0311966335776542
Pubmed

Multiple genes encoding zinc finger domains are expressed in human T cells.

ZNF17 ZNF28

1.59e-03316622288909
Pubmed

Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.

LRRK2 ZNF365

1.59e-033166221072187
Pubmed

Dissection of behavior and psychiatric disorders using the mouse as a model.

NTRK2 GRIN2A

1.59e-033166210767319
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

RANBP2 GLI3 LPP ZNF638

1.59e-0326366434702444
Pubmed

Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

TNPO1 NAA15 RBMS1 RALGAPB RMC1

1.72e-0345466533226137
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

AKAP8 RBM12B ZNF638 ERMP1 ANKHD1

1.77e-0345766532344865
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF17 ZNF28 ZNF607 ZNF780A ZNF814 ZNF227 ZNF230 SBSN

3.05e-041192668chr19q13
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF131 ZNF17 ZNF28 ZBTB39 ZBTB17 ZNF607 ZNF780A GLI3 ZNF189 ZNF300 ZNF814 ZNF860 ZNF227 ZNF230 ZNF442 ZNF365 ZBTB24

4.91e-13718451728
GeneFamilyBasic leucine zipper proteins|BTB domain containing

ZNF131 ZBTB39 ZBTB17 ZBTB24

3.40e-04134454861
GeneFamilyReceptor Tyrosine Kinases|CD molecules

NTRK2 MERTK

4.45e-0340452321
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KCNT2 GLI3 GRIN2A CPED1 CEMIP

9.01e-0618966571397e993a77d70b2eeede240bdfc7660b558987
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KCNT2 GLI3 GRIN2A CPED1 CEMIP

9.01e-061896654eea4759520c312bd17a681034d8074e47093d2b
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RBMS1 LRRK2 GRIN2A MERTK CEMIP

9.24e-061906651bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
Diseaseserum metabolite measurement

TNPO1 KCNT2 NT5C3A NTRK2 NIPAL1 ERMP1 CPED1 AGBL1

7.86e-04945628EFO_0005653
DiseaseEpilepsy

KCNT2 GRIN2A ALG13

1.58e-03109623C0014544
DiseaseEpileptic encephalopathy

PLAA ALG13

1.82e-0330622C0543888
Diseasecognitive function measurement

EFCAB5 PLAA RBMS1 GLI3 ZNF638 GRIN2A CSMD3 AGBL1 CEMIP

2.93e-031434629EFO_0008354
Diseasehippocampal CA4 volume

EFCAB5 GLI3

3.38e-0341622EFO_0009396
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

LRRK2 MERTK CSMD3

3.77e-03148623C0279702
Diseasewaist-hip ratio

KCNT2 RBMS1 GLI3 NTRK2 ERMP1 RMC1 CPED1 CEMIP

4.01e-031226628EFO_0004343

Protein segments in the cluster

PeptideGeneStartEntry
GFKGELIHVFNKHDG

NT5C3A

241

Q9H0P0
ELAKQLHKEGHLFYC

ALG13

111

Q9NP73
VGSVVQFHCKKGHLL

CSMD3

3371

Q7Z407
ICGFDIKKVHVILHF

CALR3

136

Q96L12
LQGKCGCHFHEVVKS

CPED1

946

A4D0V7
GIGQEHFFKKIEAAH

AKAP8

466

O43823
VKDNGEFHALGHKCP

AIFM3

96

Q96NN9
CKHFQNLGKDGLKYH

AFM

416

P43652
QVSPFNHGHKVAKFC

ALDH4A1

81

P30038
GHIKFALGFKAAHLE

CEMIP

526

Q8WUJ3
CVHKDFKQHGAQGKF

ERMP1

566

Q7Z2K6
VFCDFHGHSQKKNVF

AGBL1

896

Q96MI9
SGLCVDGVIFLKHHD

RBM12B

176

Q8IXT5
HLDFKHVVFGFVKDG

RANBP2

3181

P49792
TEKCEAVIGHFNGKF

RBMS1

191

P29558
EGHLHLAQFLVKDCG

ESPNL

181

Q6ZVH7
INNDHIHGEKKEFVC

GLI3

501

P10071
GHIILSEHKGVKFNC

MERTK

101

Q12866
LGGKNFDEKLVEHFC

HSPH1

231

Q92598
FKFVGKDHKEVFLHC

OIT3

481

Q8WWZ8
FHAGFHKVCGGKVLL

HERC4

916

Q5GLZ8
GKIVVGHAIHNDFKA

ISG20L2

256

Q9H9L3
VDAGGLIHCIEDFHK

LPP

516

Q93052
ELHLNFDFKHIGCKA

LRRK2

1301

Q5S007
ASFHAHKKFGVCLIG

KCNT2

511

Q6UVM3
HDFHEIEGACKRGFQ

ELAPOR2

881

A8MWY0
FGEALKKCHEIERHF

NAA15

501

Q9BXJ9
EKLVDNAGFCHHLGT

LRRIQ1

906

Q96JM4
ACLEGIFVKHKNGRH

PTPN21

236

Q16825
GFDHNFCLKGSKEKH

GALM

241

Q96C23
ELFLHCDHGKVGFLD

EFCAB5

391

A4FU69
DFVDKDGEHFGKLHC

HSPBAP1

416

Q96EW2
VVGFHHKKGCQVEFS

AVL9

21

Q8NBF6
KEADKAVQGFHTGVH

SBSN

471

Q6UWP8
FLNEHLNIHGKIGCI

NIPAL1

161

Q6NVV3
KGHFFVEDQIYCEKH

PDLIM1

296

O00151
FQHEDLIGKCHAFDG

PIWIL1

151

Q96J94
GIHHCKEGILIKDFL

SHCBP1

506

Q8NEM2
DKGHYKFCELLIHRG

ANKHD1

1301

Q8IWZ3
QHEHIVKFYGVCVEG

NTRK2

596

Q16620
EECGKGFVRKAHFIQ

ZNF189

151

O75820
VACFHLKRFEHVGKQ

USP51

591

Q70EK9
FLKIGAGCQVHVGHD

nan

46

Q8N2B8
PGEHCEEHVAFFKQI

RMC1

631

Q96DM3
VCFHKDHNIEGKAQC

PLAA

711

Q9Y263
CGKAFRQFSHLVGHK

ZNF607

286

Q96SK3
HQKFHTGEKPFECNE

ZNF780A

211

O75290
LFDAAFVHCKLHNGI

RALGAPB

451

Q86X10
FCKILHGFKNQVGDE

TNPO1

861

Q92973
CGKVLAKDFHVVRGH

ZBTB39

456

O15060
AEAGHLGKVCDFHLN

ZNF839

651

A8K0R7
ECGKGFAQKHSLQVH

ZBTB24

326

O43167
CKKAFSHFGNLKVHE

ZNF442

521

Q9H7R0
CTFVVDGVHFKAHKA

ZBTB17

26

Q13105
DGVHFKAHKAVLAAC

ZBTB17

31

Q13105
KCGRAFIHDFQLQKH

ZNF230

256

Q9UIE0
CNKFDHDRVIGFHIL

TXNRD3

571

Q86VQ6
HIGDFCFQKIEKDIH

ZNF28

81

P17035
CGKIFGHNTSLFLHK

ZNF28

276

P17035
EECGKGFTQAAHFHI

ZNF227

411

Q86WZ6
FCGGTFHHNEKDVLG

ZNF365

141

Q70YC4
HIGDFCFQKIGKDIH

ZNF860

96

A6NHJ4
HLNCYHLEEGGVSKK

ZNF131

306

P52739
ACGKAFSEKFHLVVH

ZNF300

301

Q96RE9
CVGLQFGKVDHHVFI

ZNF638

1026

Q14966
GKDFCHQHTLFEHQK

ZNF17

196

P17021
GCFAKVHQKGALKLH

ZBBX

156

A8MT70
GKCFSHKGNLILHQH

ZNF814

666

B7Z6K7
GIYSCIHGVHIEEKK

GRIN2A

866

Q12879