Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chromatin binding	SREBF1 POU5F1 RARG NFATC1 NRL LEF1 SBNO2 MEOX1 STPG4	7.71e-06	739	38	9	GO:0003682
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	SREBF1 HOXB3 POU5F1 NFATC1 NRL LEF1 NOBOX MEOX1	8.47e-06	560	38	8	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	SREBF1 HOXB3 POU5F1 NFATC1 NRL LEF1 NOBOX MEOX1	9.16e-06	566	38	8	GO:0001216
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SREBF1 HOXB3 POU5F1 RARG NFATC1 NRL LEF1 NOBOX MEOX1	4.32e-04	1244	38	9	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SREBF1 HOXB3 POU5F1 RARG NFATC1 NRL LEF1 NOBOX MEOX1	5.05e-04	1271	38	9	GO:0000987
GeneOntologyMolecularFunction	HMG box domain binding	POU5F1 MEOX1	8.70e-04	23	38	2	GO:0071837
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SREBF1 HOXB3 POU5F1 RARG NFATC1 NRL LEF1 NOBOX MEOX1	1.08e-03	1412	38	9	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SREBF1 HOXB3 POU5F1 RARG NFATC1 NRL LEF1 NOBOX MEOX1	1.36e-03	1459	38	9	GO:0000977
GeneOntologyMolecularFunction	histone binding	POU5F1 LEF1 SBNO2 STPG4	1.57e-03	265	38	4	GO:0042393
GeneOntologyMolecularFunction	transcription coregulator binding	SREBF1 NFATC1 LEF1	2.38e-03	140	38	3	GO:0001221
GeneOntologyMolecularFunction	nuclear receptor activity	SREBF1 RARG	5.82e-03	60	38	2	GO:0004879
GeneOntologyMolecularFunction	ligand-activated transcription factor activity	SREBF1 RARG	6.01e-03	61	38	2	GO:0098531
GeneOntologyBiologicalProcess	trabecula morphogenesis	NFATC1 SBNO2 CYP27B1 COL1A1	2.89e-06	57	36	4	GO:0061383
GeneOntologyBiologicalProcess	bone trabecula morphogenesis	SBNO2 CYP27B1 COL1A1	3.91e-06	18	36	3	GO:0061430
GeneOntologyBiologicalProcess	face development	HOXB3 RARG LEF1 COL1A1	4.33e-06	63	36	4	GO:0060324
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	SREBF1 HOXB3 POU5F1 RARG NFATC1 NRL LEF1 SBNO2 GPS2 NOBOX MEOX1	1.56e-05	1390	36	11	GO:0045944
GeneOntologyBiologicalProcess	response to retinoic acid	SREBF1 POU5F1 RARG COL1A1	7.82e-05	131	36	4	GO:0032526
Domain	-	HOXB3 POU5F1 PC NOBOX MEOX1	2.57e-04	283	38	5	1.10.10.60
Domain	EXOIII	REXO1L1P REXO1	3.61e-04	14	38	2	SM00479
Domain	Exonuclease_RNaseT/DNA_pol3	REXO1L1P REXO1	3.61e-04	14	38	2	IPR013520
Domain	RNase_T	REXO1L1P REXO1	3.61e-04	14	38	2	PF00929
Domain	Homeodomain-like	HOXB3 POU5F1 PC NOBOX MEOX1	5.34e-04	332	38	5	IPR009057
Domain	Homeobox	HOXB3 POU5F1 NOBOX MEOX1	1.27e-03	234	38	4	PF00046
Domain	HOMEOBOX_1	HOXB3 POU5F1 NOBOX MEOX1	1.31e-03	236	38	4	PS00027
Domain	HOX	HOXB3 POU5F1 NOBOX MEOX1	1.33e-03	237	38	4	SM00389
Domain	Homeobox_dom	HOXB3 POU5F1 NOBOX MEOX1	1.37e-03	239	38	4	IPR001356
Domain	HOMEOBOX_2	HOXB3 POU5F1 NOBOX MEOX1	1.37e-03	239	38	4	PS50071
Domain	VWFC_1	DGCR2 COL1A1	2.43e-03	36	38	2	PS01208
Domain	VWC	DGCR2 COL1A1	2.71e-03	38	38	2	SM00214
Domain	VWFC_2	DGCR2 COL1A1	2.71e-03	38	38	2	PS50184
Domain	VWF_dom	DGCR2 COL1A1	3.30e-03	42	38	2	IPR001007
Domain	Homeobox_CS	HOXB3 POU5F1 MEOX1	6.35e-03	186	38	3	IPR017970
Domain	HMG_box_dom	MIA2 LEF1	7.73e-03	65	38	2	IPR009071
Domain	RNaseH-like_dom	REXO1L1P REXO1	8.68e-03	69	38	2	IPR012337
Domain	HTH_motif	HOXB3 MEOX1	8.68e-03	69	38	2	IPR000047
Domain	SH3_2	MIA2 SNX18	1.32e-02	86	38	2	IPR011511
Domain	SH3_2	MIA2 SNX18	1.32e-02	86	38	2	PF07653
Domain	Homeobox_metazoa	HOXB3 MEOX1	1.44e-02	90	38	2	IPR020479
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SREBF1 FBRSL1 DGCR2 RARG PC NFATC1 REXO1 PI4KA SBNO2 COL1A1	2.77e-07	1105	39	10	35748872
Pubmed	A census of human transcription factors: function, expression and evolution.	SREBF1 HOXB3 POU5F1 RARG NFATC1 NRL LEF1 NOBOX MEOX1	5.68e-07	908	39	9	19274049
Pubmed	Prognostic value of association of OCT4 with LEF1 expression in esophageal squamous cell carcinoma and their impact on epithelial-mesenchymal transition, invasion, and migration.	POU5F1 LEF1	1.23e-06	2	39	2	29974668
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	SREBF1 POU5F1 RARG NFATC1 NRL LEF1 MEOX1	2.20e-06	544	39	7	28473536
Pubmed	Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors.	NRL COL1A1	3.67e-06	3	39	2	26140606
Pubmed	Luteolin and apigenin activate the Oct-4/Sox2 signal via NFATc1 in human periodontal ligament cells.	POU5F1 NFATC1	3.67e-06	3	39	2	27449921
Pubmed	The NOBOX protein becomes undetectable in developmentally competent antral and ovulated oocytes.	POU5F1 NOBOX	3.67e-06	3	39	2	23585350
Pubmed	Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis.	NFATC1 LEF1 COL1A1	3.74e-06	27	39	3	23824573
Pubmed	A reprogrammable mouse strain from gene-targeted embryonic stem cells.	POU5F1 COL1A1	7.34e-06	4	39	2	20010832
Pubmed	Characterization of NOBOX DNA binding specificity and its regulation of Gdf9 and Pou5f1 promoters.	POU5F1 NOBOX	7.34e-06	4	39	2	16997917
Pubmed	Regulatory Dynamics of Tet1 and Oct4 Resolve Stages of Global DNA Demethylation and Transcriptomic Changes in Reprogramming.	POU5F1 COL1A1	7.34e-06	4	39	2	32075734
Pubmed	Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues.	POU5F1 COL1A1	7.34e-06	4	39	2	15882627
Pubmed	Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-kappaB and LEF-1.	LEF1 COL1A1	1.22e-05	5	39	2	20018240
Pubmed	A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue.	POU5F1 COL1A1	1.22e-05	5	39	2	28429718
Pubmed	Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 transcription factor.	SREBF1 RARG	1.22e-05	5	39	2	18202130
Pubmed	Regulation of the Oct-4 gene by nuclear receptors.	POU5F1 RARG	1.22e-05	5	39	2	8152920
Pubmed	Quiescent Oct4+ Neural Stem Cells (NSCs) Repopulate Ablated Glial Fibrillary Acidic Protein+ NSCs in the Adult Mouse Brain.	POU5F1 COL1A1	1.22e-05	5	39	2	28733998
Pubmed	Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.	POU5F1 COL1A1	1.83e-05	6	39	2	18371336
Pubmed	Wnt/β-catenin signaling enables developmental transitions during valvulogenesis.	NFATC1 LEF1	1.83e-05	6	39	2	26893350
Pubmed	Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility.	POU5F1 NOBOX	2.56e-05	7	39	2	19020301
Pubmed	Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro.	POU5F1 PC	2.56e-05	7	39	2	28254784
Pubmed	Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts.	NFATC1 COL1A1	2.56e-05	7	39	2	17430895
Pubmed	Pluripotency factors regulate the onset of Hox cluster activation in the early embryo.	POU5F1 COL1A1	2.56e-05	7	39	2	35857513
Pubmed	Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis.	LEF1 COL1A1	2.56e-05	7	39	2	23133399
Pubmed	Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures.	POU5F1 COL1A1	2.56e-05	7	39	2	29514090
Pubmed	Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4, c-Myc, Sox2 and Klf4.	POU5F1 COL1A1	2.56e-05	7	39	2	28052023
Pubmed	MyoD gene suppression by Oct4 is required for reprogramming in myoblasts to produce induced pluripotent stem cells.	POU5F1 COL1A1	2.56e-05	7	39	2	21425413
Pubmed	Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.	POU5F1 COL1A1	2.56e-05	7	39	2	29249356
Pubmed	NFATC1 promotes epicardium-derived cell invasion into myocardium.	NFATC1 COL1A1	3.42e-05	8	39	2	21447555
Pubmed	Critical roles of Cyclin D1 in mouse embryonic fibroblast cell reprogramming.	POU5F1 COL1A1	3.42e-05	8	39	2	27790870
Pubmed	Retinoic acid regulates a subset of Cdx1 function in vivo.	HOXB3 RARG	3.42e-05	8	39	2	14660544
Pubmed	A rapid and scalable system for studying gene function in mice using conditional RNA interference.	POU5F1 COL1A1	3.42e-05	8	39	2	21458673
Pubmed	The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression.	POU5F1 COL1A1	3.42e-05	8	39	2	22669820
Pubmed	Loss of ADAMTS19 causes progressive non-syndromic heart valve disease.	LEF1 COL1A1	4.39e-05	9	39	2	31844321
Pubmed	Tissue-specific knockout of E-cadherin (Cdh1) in developing mouse gonads causes germ cells loss.	POU5F1 COL1A1	4.39e-05	9	39	2	31100714
Pubmed	Molecular characterization of seizure-related genes isolated by differential screening.	DGCR2 SEZ6	4.39e-05	9	39	2	8645260
Pubmed	Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming.	POU5F1 COL1A1	4.39e-05	9	39	2	30017590
Pubmed	Gene mapping of SEZ group genes and determination of pentylenetetrazol susceptible quantitative trait loci in the mouse chromosome.	DGCR2 SEZ6	5.48e-05	10	39	2	10700579
Pubmed	Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart.	NFATC1 COL1A1	5.48e-05	10	39	2	22687751
Pubmed	A role for primary cilia in aortic valve development and disease.	NFATC1 COL1A1	5.48e-05	10	39	2	28556366
Pubmed	Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.	NFATC1 SBNO2	5.48e-05	10	39	2	23980096
Pubmed	FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney.	LEF1 COL1A1	5.48e-05	10	39	2	24284212
Pubmed	DZIP1 regulates mammalian cardiac valve development through a Cby1-β-catenin mechanism.	LEF1 COL1A1	6.70e-05	11	39	2	33811421
Pubmed	Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation.	CYP27B1 COL1A1	6.70e-05	11	39	2	19197242
Pubmed	N-Cadherin Is Critical for the Survival of Germ Cells, the Formation of Steroidogenic Cells, and the Architecture of Developing Mouse Gonads.	POU5F1 COL1A1	6.70e-05	11	39	2	31835801
Pubmed	The vitamin D receptor is not required for fetal mineral homeostasis or for the regulation of placental calcium transfer in mice.	CYP27B1 COL1A1	6.70e-05	11	39	2	15741244
Pubmed	Developmental basis for filamin-A-associated myxomatous mitral valve disease.	NFATC1 COL1A1	6.70e-05	11	39	2	22843703
Pubmed	Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development.	POU5F1 MEOX1	8.03e-05	12	39	2	25739401
Pubmed	The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts.	POU5F1 RTN1	8.03e-05	12	39	2	15893969
Pubmed	BMP2 expression in the endocardial lineage is required for AV endocardial cushion maturation and remodeling.	NFATC1 COL1A1	8.03e-05	12	39	2	28790014
Pubmed	GATA3 mediates nonclassical β-catenin signaling in skeletal cell fate determination and ectopic chondrogenesis.	LEF1 COL1A1	8.03e-05	12	39	2	36449606
Pubmed	Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice.	MIA2 COL1A1	9.48e-05	13	39	2	11839810
Pubmed	Loss of flow responsive Tie1 results in Impaired Aortic valve remodeling.	NFATC1 COL1A1	1.11e-04	14	39	2	31319059
Pubmed	Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin.	NFATC1 COL1A1	1.11e-04	14	39	2	32151560
Pubmed	Zic3 is critical for early embryonic patterning during gastrulation.	POU5F1 MEOX1	1.11e-04	14	39	2	16397896
Pubmed	Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium.	NFATC1 COL1A1	1.11e-04	14	39	2	28809397
Pubmed	ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.	POU5F1 LEF1	1.27e-04	15	39	2	29735715
Pubmed	Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis.	LEF1 COL1A1	1.27e-04	15	39	2	30595533
Pubmed	Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types.	NFATC1 LEF1	1.27e-04	15	39	2	28512199
Pubmed	Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis.	HOXB3 MEOX1	1.27e-04	15	39	2	18304314
Pubmed	Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.	LEF1 COL1A1	1.27e-04	15	39	2	15866165
Pubmed	Epicardial calcineurin-NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development.	NFATC1 COL1A1	1.27e-04	15	39	2	23946498
Pubmed	Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis.	NFATC1 LEF1	1.46e-04	16	39	2	29056552
Pubmed	Two distinct pathways of pregranulosa cell differentiation support follicle formation in the mouse ovary.	POU5F1 COL1A1	1.46e-04	16	39	2	32759216
Pubmed	The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification.	LEF1 COL1A1	1.46e-04	16	39	2	21571217
Pubmed	Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis.	LEF1 COL1A1	1.65e-04	17	39	2	30635573
Pubmed	Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation.	NFATC1 LEF1	1.65e-04	17	39	2	26992132
Pubmed	Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells.	POU5F1 NOBOX	1.65e-04	17	39	2	21504946
Pubmed	Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo.	POU5F1 MEOX1	1.85e-04	18	39	2	15084457
Pubmed	Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice.	LEF1 COL1A1	2.07e-04	19	39	2	32290615
Pubmed	Segmental variations in trabecular bone density and microstructure of the spine in senescence-accelerated mouse (SAMP6): a murine model for senile osteoporosis.	LEF1 COL1A1	2.07e-04	19	39	2	22342532
Pubmed	Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis.	LEF1 COL1A1	2.07e-04	19	39	2	15866164
Pubmed	A Wnt/Notch/Pax7 signaling network supports tissue integrity in tongue development.	LEF1 COL1A1	2.07e-04	19	39	2	28438836
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	HOXB3 RARG LEF1 MEOX1	2.13e-04	263	39	4	20932939
Pubmed	Sequential roles of Hedgehog and Wnt signaling in osteoblast development.	LEF1 COL1A1	2.30e-04	20	39	2	15576404
Pubmed	Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo.	POU5F1 MEOX1	2.30e-04	20	39	2	9790191
Pubmed	Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling.	RARG LEF1	2.30e-04	20	39	2	28154153
Pubmed	KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis.	LEF1 COL1A1	2.30e-04	20	39	2	38113115
Pubmed	Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryo.	POU5F1 MEOX1	2.54e-04	21	39	2	21953618
Pubmed	Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation.	LEF1 COL1A1	2.54e-04	21	39	2	22434869
Pubmed	Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia.	RARG COL1A1	2.54e-04	21	39	2	23650387
Pubmed	MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice.	POU5F1 NRL	2.54e-04	21	39	2	29324782
Pubmed	Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/β-catenin signaling.	LEF1 COL1A1	2.54e-04	21	39	2	34172578
Pubmed	Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments.	NFATC1 LEF1	2.79e-04	22	39	2	21464233
Pubmed	Fibroblast growth factor receptor-Frs2α signaling is critical for nephron progenitors.	LEF1 MEOX1	2.79e-04	22	39	2	25641696
Pubmed	Epithelial Wnt/βcatenin signalling is essential for epididymal coiling.	POU5F1 LEF1	2.79e-04	22	39	2	26934381
Pubmed	Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets.	POU5F1 LIX1	3.05e-04	23	39	2	20089898
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	POU5F1 NOBOX	3.05e-04	23	39	2	19480014
Pubmed	Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning.	NFATC1 LEF1	3.05e-04	23	39	2	16314491
Pubmed	Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary.	POU5F1 LEF1	3.05e-04	23	39	2	18250098
Pubmed	Global gene expression analysis of murine limb development.	RARG LEF1 LIX1	3.10e-04	117	39	3	22174793
Pubmed	Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin.	NFATC1 LEF1	3.33e-04	24	39	2	32186512
Pubmed	The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.	POU5F1 MEOX1	3.33e-04	24	39	2	16582099
Pubmed	RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary.	POU5F1 LEF1	3.33e-04	24	39	2	21991325
Pubmed	Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm.	LEF1 MEOX1	3.62e-04	25	39	2	38345319
Pubmed	Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands.	RARG BCO2	3.62e-04	25	39	2	31562240
Pubmed	Risk of meningomyelocele mediated by the common 22q11.2 deletion.	PI4KA MEOX1	3.62e-04	25	39	2	38696583
Pubmed	Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8.	POU5F1 NOBOX	3.62e-04	25	39	2	16690745
Pubmed	Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation.	LEF1 MEOX1	3.91e-04	26	39	2	22130515
Pubmed	Arrest of WNT/β-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries.	POU5F1 LEF1	3.91e-04	26	39	2	34301885
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	HOXB3 ATP6V0A1 COL1A1 MEOX1	6.88e-04	473	39	4	chr17q21
Cytoband	19p13.3	PRR22 REXO1 SBNO2	1.08e-03	237	39	3	19p13.3
Cytoband	17q21	ATP6V0A1 MEOX1	1.33e-03	63	39	2	17q21
Cytoband	22q11.21	DGCR2 PI4KA	4.05e-03	111	39	2	22q11.21
Cytoband	Ensembl 112 genes in cytogenetic band chr22q11	DGCR2 PI4KA GUSBP11	5.41e-03	419	39	3	chr22q11
GeneFamily	HOXL subclass homeoboxes	HOXB3 MEOX1	1.81e-03	52	22	2	518
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated\|Lung / Manually curated celltypes from each tissue	GDPGP1 LEF1 COL1A1 MEOX1	1.15e-05	160	39	4	9f7f24a52a24fb926df69c8e5aad64ee75a66ef1
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D175\|Adult / Lineage, Cell type, age group and donor	PTPN23 PRR22 RARG COL1A1	1.18e-05	161	39	4	048b7dc00746987a24bf870d4d278c4183eb04a2
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASIC4 RTN1 LIX1 SEZ6	1.95e-05	183	39	4	7e2bac8b005155888ff4b41ef2e1d975dc17abc7
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASIC4 RTN1 LIX1 SEZ6	2.08e-05	186	39	4	15f2e5905486e33f6f7b3b3e9758a0559e8c61ee
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASIC4 RTN1 LIX1 SEZ6	2.60e-05	197	39	4	5593721407f61fc5bc3f2f8bf8fa2604c4e29565
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASIC4 RTN1 LIX1 SEZ6	2.60e-05	197	39	4	a1ae1aa797762a3768e14434c7e5cd19c595ecb3
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SREBF1 PC LIX1 KCTD3	2.65e-05	198	39	4	a7e5de81eb7d3d23812c179a001adbaab1506596
ToppCell	15-Airway\|15 / Age, Tissue, Lineage and Cell class	PLSCR4 RARG RTN1 COL1A1	2.76e-05	200	39	4	ba4b8d5becf81351901c2ecac74ffa28e29586f3
Drug	apocarotenal	PLSCR4 SREBF1 BCO2 COL1A1 MEOX1	2.98e-07	83	39	5	ctd:C004984
Drug	Cryptoxanthins	BCO2 NFATC1 COL1A1	7.00e-06	22	39	3	ctd:D065366
Drug	beta Carotene	PLSCR4 SREBF1 BCO2 COL1A1 MEOX1	1.18e-05	175	39	5	ctd:D019207
Drug	AGN 193109	SREBF1 POU5F1 RARG	1.83e-05	30	39	3	ctd:C096920
Drug	Piretanide [55837-27-9]; Up 200; 11uM; MCF7; HT_HG-U133A	ATP6V0A1 PC NFATC1 NRL COL1A1	2.09e-05	197	39	5	3567_UP
Disease	rheumatic heart disease (biomarker_via_orthology)	LEF1 COL1A1	1.06e-04	12	38	2	DOID:0050827 (biomarker_via_orthology)
Disease	Ovarian Failure, Premature	POU5F1 NOBOX	3.34e-04	21	38	2	C0085215
Disease	kidney disease (biomarker_via_orthology)	SREBF1 NFATC1	3.34e-04	21	38	2	DOID:557 (biomarker_via_orthology)
Disease	proline measurement	DGCR2 NOBOX	5.15e-04	26	38	2	EFO_0009773
Disease	basal cell carcinoma	FBRSL1 SBNO2 CYP27B1	1.85e-03	189	38	3	EFO_0004193

Protein segments in the cluster

Peptide	Gene	Start	Entry
PPAPGVFAGFHYPQD	FBRSL1	631	Q9HCM7
GAYGTAQPPPHYGPT	GPS2	186	Q13227
PHPVVFLPGTGYPKG	GUSBP11	211	Q6P575
GFYPSEPVFVPAPGT	BCO2	511	Q9BYV7
PGSGYPGAGFPFAFP	RARG	16	P13631
FPSSTGPGPHYLSGP	PTPN23	776	Q9H3S7
GASGLPHYPPTPFSF	MEOX1	31	P50221
GHPPGGDGYFPDLFP	NOBOX	616	O60393
PDIPTFYPLSPGGVG	LEF1	191	Q9UJU2
EGPTPHPFASLPFGF	CYP27B1	436	O15528
PRDGYGSPHHTPPYG	MPLKIP	41	Q8TAP9
EYFVAGTHPYPPGPG	PLRG1	91	O43660
PEYNSHFLPGPPGTA	PLSCR4	31	Q9NRQ2
PSTFPLYQPVGGIHP	PLSCR4	66	Q9NRQ2
GQGPVPVDGPHGYYP	NRL	101	P54845
PVDGPHGYYPGSPEE	NRL	106	P54845
TPGIIPPADHPSGYG	NFATC1	76	O95644
PPPSSPGGSAFHYFE	PI4KA	271	P42356
PAPGFLFYTRGPGPD	GDPGP1	251	Q6ZNW5
PPYIHQLGFGVSPGF	ASIC4	261	Q96FT7
APGPPFVSYVTLPGG	LIX1	61	Q8N485
SGGPVSFPLAPGPHF	POU5F1	306	Q01860
SFPLAPGPHFGTPGY	POU5F1	311	Q01860
PGPHFGTPGYGSPHF	POU5F1	316	Q01860
YPGSNGFGFDVPPQP	HOXB3	21	P14651
KENGYPFPHPERPGG	REXO1L1P	381	Q8IX06
GGTFHFHDPPPPYTA	DGCR2	421	P98153
LGPPGTPTFYDFNPH	KIRREL2	631	Q6UWL6
GSVLFHGYLPPPGIP	KCTD3	121	Q9Y597
YFHPPGTPAPGRGVG	IL17RC	766	Q8NAC3
GFFPPPPHSEGRSEF	MIA2	1376	Q96PC5
YVSFGHVGGPPPSPA	RTN1	431	Q16799
ENGYPFPHPERPGGA	REXO1	941	Q8N1G1
VPVPQGYPGGVPTFF	SBNO2	921	Q9Y2G9
PVLGYPSPPGGFSTG	SREBF1	161	P36956
PGPPGPPSAGFDFSF	COL1A1	1186	P02452
LVPAFFYSPPPGGSF	nan	31	Q8TAT8
YFPPEGPGPEALGFV	PRR22	146	Q8IZ63
FPTTYFIPHEGPGPG	STPG4	166	Q8N801
PSTFQPPGAGFPYGG	SNX18	116	Q96RF0
SLPPPAGPGTFHFHY	SEZ6	336	Q53EL9
LPGVFGGPYPFGIDP	ATP6V0A1	506	Q93050
YIGVPHGGFPEPFRS	PC	951	P11498
YGHEGFGPPAPAPRD	ZFTA	651	C9JLR9